Ntchito malangizo Metformin

Metformin ndi mankhwala amkamwa a hypoglycemic pochizira matenda a shuga a mtundu wachiwiri.

Mankhwala amalepheretsa gluconeogenesis m'chiwindi, amachepetsa mayamwidwe m'matumbo, amalimbikitsa kugwiritsidwa ntchito kwa glucose, komanso kumakulitsa chidwi cha minofu kuti insulin.

Sichikukhudzana ndi kubisika kwa insulini ndi ma cell a beta, sikuti kumayambitsa kutengeka kwa hypoglycemic.

Amachepetsa mulingo wa mahomoni olimbikitsa chithokomiro mu seramu yamagazi, kuchuluka kwa cholesterol ndi lipoproteins yotsika, komanso kumalepheretsa kusintha kwamitsempha yamagazi.

Kugwiritsidwa ntchito kwa Metformin kumathandizira kubwezeretsa magazi m'magazi, kusintha kayendedwe ka magazi, komanso kuchepetsa mwayi wa thrombosis. Kuphatikiza apo kumathandizira kuchepetsa kunenepa kwambiri.

Chipangidwe Metformin (piritsi limodzi):

• Metformin - 500 mg
• Omwe amachokera: povidone, wowonda chimanga, crospovidone, magnesium stearate, talc,
• Mapangidwe a Shell: methaconic acid ndi methylryacoplate kopolymer, macrogol, titanium dioxide, talc.

Zizindikiro zogwiritsidwa ntchito

Kodi Metformin ndi chiyani? Malinga ndi malangizo, mankhwalawa amalembedwa motere:

• Monga mankhwala amodzi omwe amagwiritsidwa ntchito mwa anthu odwala matenda ashuga a 2 popanda chizolowezi cha ketoacidosis ndi kusachita bwino kwa mankhwala othandizira (makamaka kwa odwala omwe ali onenepa kwambiri).
• Kuphatikiza ndi insulin, mankhwalawa amagwiritsidwa ntchito mtundu wa 2 matenda a shuga, omwe amathandizana ndi yachiwiri ya insulin (makamaka kwa odwala omwe ali ndi kunenepa kwambiri).

Malangizo ogwiritsira ntchito Metformin, mlingo

Mankhwalawa amayenera kumwedwa pakamwa popanda kudya piritsi kapena pakudya. Mlingo weniweni umakhazikitsidwa payekhapayekha kwa wodwala aliyense, kutengera kupenda kwamishuga yamagazi.

Mlingo woyambirira wa akuluakulu omwe analimbikitsidwa ndi Metformin ndi 500 mg kuchokera 1 mpaka 3 kawiri pa tsiku kapena 850 mg kuchokera 1 mpaka 2 pa tsiku. Ngati ndi kotheka, pakatikati pa sabata limodzi, mlingo umakulitsidwa pang'onopang'ono, mpaka 2000-3000 mg.

Mlingo wovomerezeka tsiku lililonse kwa okalamba ndi 1000 mg.

Mlingo woyambirira wa ana opitirira zaka 10 ndi 500 kapena 850 mg 1 nthawi patsiku kapena 500 mg 2 kawiri pa tsiku. Ngati ndi kotheka, tsiku lililonse mlingo umakulitsidwa pang'onopang'ono, mpaka 2000 mg mu 2-3 Mlingo.

Mukamapangira mankhwala ophatikiza, mlingo wa Metformin malinga ndi malangizo amachokera ku 500 mpaka 850 mg 2-3 kawiri pa tsiku. Mlingo wa insulin umasankhidwa payekha kutengera kuchuluka kwa shuga m'magazi.

Kupezeka kwakukulu kwa mankhwalawa m'madzi am'magazi kumachitika pakatha maola awiri pambuyo pa utsogoleri, pambuyo pa maola 6 akuyamba kutsika. Pambuyo masiku awiri akumwa pafupipafupi, kuphatikizira kwa mankhwalawo m'magazi kumakhazikitsidwa.

Kusintha kwa mankhwalawa kumalimbikitsidwa patatha masiku 7 mpaka 15 atayamba kumwa mankhwalawa.

Chifukwa chowonjezera chiopsezo cha lactic acidosis, mlingo uyenera kuchepetsedwa pazovuta zazikulu za metabolic.

Zotsatira zoyipa

Malangizowa amachenjeza za mwayi wopanga zotsatirazi zoyipa popanga Metformin:

• Matumbo a pakhungu - "chitsulo" pakamwa, mseru, kusanza kwakanthawi, kupweteka kwam'mimba, kutsegula m'mimba, kusowa chilakolako cha chakudya mpaka kusowa kwathunthu (anorexia), flatulence (kuchuluka kwa mpweya m'mimba).
• Dongosolo la endocrine ndi hypoglycemia (kuchepa kwa ndende yamagazi m'munsi mwabwinobwino).
• Metabolism - lactic acidosis (kuchuluka kwa lactic acid m'magazi), kuyamwa kwa vitamini B12 m'matumbo.
• Magazi ndi mafupa ofiira - kuchepa kwa magazi m'thupi (megaloblastic anemia) (kuchepa kwa magazi ndi kupindika kwa maselo ofiira am'magazi chifukwa cha kuperewera kwa vitamini B12) sikungatheke.
• Thupi lawo siligwirizana - zotupa pakhungu ndi kuyabwa.

Zotsatira zoyipa zam'mimba zimayambira kumayambiriro kwa mankhwalawa ndi mankhwalawa ndikudziwonekera pazokha. Kuti achepetse kuopsa kwa zizindikiro posachedwa, ma antacid, antispasmodics ndi mankhwala ofanana ndi atropine amalembedwa ndi adokotala.

Contraindication

Metformin imatsutsana pazochitika zotsatirazi:

• Kuchepa kwa chiwindi kapena impso.
• Lactic acidosis (kuphatikizapo mbiri)
• Matenda a shuga ketoacidosis
• Uchidakwa wambiri kapena chakumwa choledzeretsa chachikulu,
• Matenda a matenda ashuga, chikomokere
• Matenda akufotokozera za matenda osachiritsika komanso osakhazikika omwe angayambitse kukula kwa minofu hypoxia (mwachitsanzo, kupuma kapena mtima kupuma, infaration yokomera mtima),
• Kutsatira zakudya zama hypocaloric (mukamadya mafuta ochepera 1000 patsiku),
• Matenda owopsa omwe ali ndi chiopsezo chokhala ndi vuto la impso, mwachitsanzo, kusowa kwam'mimba ndikusanza kapena kutsekula m'mimba, matenda opatsirana kwambiri, kutentha thupi, hypoxia (yokhala ndi matenda a bronchopulmonary, matenda a impso, sepsis, mantha),
• Gwiritsani ntchito masiku awiri lisanachitike komanso patadutsa masiku awiri mutachitika maphunziro a radiology kapena radioisotope ndikukhazikitsa njira yothandizira yomwe ilinso ndi ayodini,
• Kuvulala kwakukulu ndi opaleshoni (ngati pakufunika chithandizo cha insulin),
• Mimba komanso kuyamwa
• Kukhalapo kwa hypersensitivity kwa metformin hydrochloride kapena mankhwala othandizira aliwonse.

Lemberani mosamala anthu opitilira zaka 60 omwe akuchita ntchito yayikulu yoopsa (chiopsezo chotenga lactic acidosis).

Bongo

Ngati bongo, lactic acidosis ingakhale, zizindikiro - kusanza, nseru, kupweteka kwa minofu, kutsegula m'mimba, kupweteka kwam'mimba. Ngati thandizo siliperekedwa munthawi yake, chizungulire, chikumbumtima chovulala komanso matendawa amatha.

Njira yothandiza kwambiri yochotsa metformin m'thupi ndi hemodialysis. Chotsatira, chithandizo chamankhwala chimayikidwa.

Analogs Metformin, mtengo pama pharmacies

Ngati ndi kotheka, mutha kuyika Metformin ndi analogue yogwira ntchito - awa ndi mankhwala:

Mukamasankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Metformin, mtengo ndi zowunikira sizigwira ntchito ndi mankhwala omwe ali ndi vuto lofananalo. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mtengo muma pharmacies aku Russia: Mapiritsi a Metformin 500 mg 60 - kuchokera ku 90 mpaka ma ruble, Metformin Zentiva 850 mg 30 magome - kuchokera ku ruble 93 mpaka 149, mtengo wa Metformin canon 500 mg 60 mapiritsi 60 - kuchokera ku ma ruble 130 mpaka 200, malinga ndi ma pharmacies a 726.

Sungani pamalo owuma osafikirika ndi ana pa kutentha kwa + 15 ... + 25 ° C. Moyo wa alumali ndi zaka zitatu.

Zotsatira za pharmacological

Metformin ndi chinthu chamgulu. khwawa, momwe amagwirira ntchito akuwonekera chifukwa cha kulepheretsa mphamvu ya gluconeogeneis m'chiwindi, kumachepetsa kuyamwa kwa glucose m'matumbo, kumathandizira njira yogwiritsira ntchito kufalikira kwa glucose, kumakulitsa kuchuluka kwa minyewa kumva insulin. Zisakhudze njira ya insulin katulutsidwe ka beta maselo a kapamba, sizimawonetsa kuwonetsa kwa hypoglycemic. Zotsatira zake, imayima hyperinsulinemia, chomwe ndichinthu chofunikira chothandizira kukulitsa kulemera ndi kupita patsogolo kwa zovuta zama mtima mkati matenda ashuga. Mothandizidwa ndi iye, thupi limakhazikika kapena kuchepa.

Chida chimachepetsa zomwe zili magazitriglyceridesndi ma linoproteinkachulukidwe kakang'ono. Imachepetsa kuchepa kwa mafuta oxidation, amalepheretsa kupanga ma free acid acid. Mphamvu yake ya fibrinolytic imadziwika, kuletsa PAI-1 ndi t-PA.

Mankhwala amaletsa kukula kwa kufalikira kwa minofu yosalala ya khoma la mtima. Zabwino pa boma la mtima dongosolo, kumalepheretsa chitukuko matenda ashuga angiopathy.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mapiritsi okhala ndi interic, Metformin ali ndi mawonekedwe ozungulira, mawonekedwe a biconvex ndi mtundu woyera. Chofunikira chachikulu pa mankhwalawa ndi metformin hydrochloride, zomwe zili piritsi limodzi ndi 500 mg. Komanso, momwe zimapangidwira zimaphatikizapo zinthu zothandiza, zomwe zimaphatikizapo:

• Crospovidone.
• Talc.
• Magnesium wakuba.
• Wowuma chimanga.
• Methaconic acid ndi methylryacoplate patyl.
• Povidone K90.
• Titanium dioxide
• Macrogol 6000.

Mapiritsi a Metformin amaikidwa mu chithuza chamtundu wa zidutswa 10. Phukusi la makatoni limakhala ndi matuza atatu (mapiritsi 30) ndi kofotokozera wogwiritsa ntchito mankhwalawo.

Kodi Metformin ndi chiyani?

Kutenga mapiritsi a Metformin kukuwonetsedwa kuchepetsa kuchuluka kwa shuga m'magazi osagwirizana ndi inshuwaransi yokhala ndi shuga 2 pakalibe njira yochizira kuchokera pakukonzanso zakudya. Mankhwalawa amagwiritsidwanso ntchito limodzi ndi insulin chifukwa cha matenda oopsa a shuga 2, makamaka kwa anthu omwe ali ndi thupi lochulukirapo.

Contraindication

Kutenga mapiritsi a Metformin kuli kotsutsana pamaso pa zingapo zamomwe timayendedwe komanso thupi.

• Hypersensitivity kwa yogwira mankhwala kapena othandizira zigawo za mankhwala.
• Matenda a shuga a ketoacidosis (kuwonetsa kuchuluka kwa shuga m'magazi ndi kusintha kwa matupi a ketone m'thupi), matenda a shuga ndi chikomokere (amachititsa chidwi cha matenda osokoneza bongo).
• Matenda a impso.
• Pachimake matenda, amene limodzi ndi chiopsezo chotenga aimpso kulephera - kuchepa kwa madzi m'thupi (thupi) ndi kwambiri kutsegula m'mimba, kusanza, pachimake matenda matenda ndi kuledzera kwambiri ndi kutentha thupi.
• Zokhudza hypoxia mu sepsis (magazi poyizoni), pachimake myocardial infarction (kufa kwa gawo la minofu ya mtima), mtima kapena kupuma.
• Kuchita njira zopangira opaleshoni yama volumetric, adavulala kwambiri, zomwe zimafuna kuti ayambitse insulin kuti akonzenso bwino (kuchiritsa) kwa minofu m'dera lowonongeka.
• Kuphwanya magwiridwe antchito a chiwindi.
• Ntchito mkati mwa masiku awiri isanakwane kapena itatha radioisotope ndi radiographic maphunziro a thupi omwe amayambitsidwa ndi kukhazikitsidwa kwa radioot isotope wa ayodini.
• Lactic acidosis (kuchuluka kwa lactic acid m'magazi, ndikutsatira kusintha kwake pazomwe zimayambitsa acidic), kuphatikizapo zakale.
• Kutsatira ndi zakudya zama calorie otsika (m'munsimu 1000 kcal patsiku).
• Mimba nthawi iliyonse yamaphunziro ndi kuyamwitsa.

Mosamala, mapiritsi a Metformin amagwiritsidwa ntchito mwa anthu opitilira zaka 60 kapena motsutsana ndi maziko olimbitsa thupi (chiwopsezo chachikulu cha kuchuluka kwa lactic acid m'magazi). Musanayambe kumwa mankhwalawa, onetsetsani kuti palibe zotsutsana.

Mlingo ndi makonzedwe

Mapiritsi a Metformin amatengedwa pakamwa ndi chakudya kapena atangomaliza kumwa. Osatafuna piritsi ndi kumwa madzi ambiri. Kuchepetsa mwayi wokhala ndi zovuta m'mimba, njira ya tsiku ndi tsiku imatengedwa, ndikugawikana mu Mlingo wa 2-3. Dokotala amakhazikitsa mlingo ndi mankhwalawa a mankhwalawo payekhapayekha, kutengera mphamvu yoyamba ya shuga m'magazi, komanso chithandiziro chothandiza. Nthawi zambiri, mlingo woyambira ndi 500-1000 mg patsiku (mapiritsi 1-2). Pambuyo masiku 10-15, kutengera kuchuluka kwa kuchuluka kwa shuga m'magazi, ndizotheka kuwonjezera kuchuluka kwa mapiritsi a Metformin mpaka 1500-2000 mg patsiku. Mlingo wambiri watsiku ndi tsiku sayenera kupitirira 3000 mg. Mwa anthu okalamba, pazipita tsiku lililonse pazichiritsidwe zochiritsira siziyenera kupitirira 1000 mg.

Malangizo apadera

Musanayambe kumwa mapiritsi a Metformin, muyenera kuwerengera mosamala malangizo a mankhwalawo. Pali malangizo angapo okhudza kugwiritsidwa ntchito kwake, omwe akuphatikizapo:

• Ndi kuwoneka kwa kupweteka kwa minofu (myalgia) mankhwala atayamba, kutsimikiza kwa labotale kwa mulingo wa lactic acid kumachitika.
• Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumafunikira kuwunikira pafupipafupi maulalo a ntchito ya impso.
• Ndi kuphatikiza kwa mapiritsi a Metformin okhala ndi mankhwala ochokera ku sulfonylureas, kuwunika kwamisempha wamagazi pafupipafupi kumafunikira.
• Pa nthawi ya mankhwala ayenera kupewa mowa ndi mankhwala okhala Mowa.
• Mapiritsi a Metformin amatha kuyanjana ndi mankhwala a magulu ena a pharmacological, chifukwa chake, mukamamwa, ndikofunikira kuchenjeza adokotala omwe akupezekapo.
• Ngati zizindikiro za bronchopulmonary ndi genitourinary pathology zikuwonekera kumbuyo kwa kumwa mankhwalawa, kugwiritsa ntchito kwake kuyenera kuyimitsidwa ndikuyang'ana kwa dokotala.
• Mankhwala samakhudzana mwachindunji ndi magwiridwe antchito a ubongo. Komabe, mukagwiritsidwa ntchito ndi mankhwala ena ochepetsa shuga, chiwopsezo cha hypoglycemia chimawonjezeka, chifukwa chake, pogwira ntchito yofunikira pakuwonetsetsa kwambiri komanso kuthamanga kwa zochitika za psychomotor, muyenera kusamala.

Pulogalamu yamankhwala, mapiritsi a Metformin amapezeka pamankhwala. Kudziyang'anira nokha popanda mankhwala oyenera sikulimbikitsidwa.

Bongo

Ndiwowonjezera pazovomerezeka zochizira mapiritsi a Metformin, ndende ya lactic acid m'magazi imatuluka (lactic acidosis). Izi zimayendera limodzi ndi mseru, kusanza, kutsegula m'mimba, kuchepa kwa kutentha kwa thupi, kupweteka m'misempha ndi m'mimba, komanso kupumira mwachangu. Pankhaniyi, mankhwalawa ayenera kusiyidwa. Chithandizo chachikulu cha bongo chimachitika kuchipatala mothandizidwa ndi hemodialysis (kuyeretsa magazi kwa magazi).

Malinga ndi yogwira ntchito komanso njira yothandizira, mankhwalawa Metfogamma, Glucofage, Formmetin ndi ofanana ndi mapiritsi a Metformin.

Pharmacokinetics ndi pharmacodynamics

Metformin itagwiritsidwa pakamwa, kupindika kwakukulu kumawonedwa mu plasma pambuyo maola 2,5. Mwa anthu omwe amalandira mankhwalawa muyezo waukulu, zomwe zili kwambiri pazomwe zimagwiritsidwa ntchito m'madzi a m'magazi sizinali zapamwamba kuposa 4 μg / ml.

Mafuta a yogwira pophika ayimitsa maola 6 mutatha kukhazikitsa. Zotsatira zake, ndende ya plasma imachepa. Ngati wodwala amatenga Mlingo wa mankhwalawa, ndiye kuti pambuyo pa masiku awiri osasunthika okhazikika omwe ali ndi chidwi ndi gawo la 1 μg / ml kapena kuchepera kumawonekera plasma.

Ngati mankhwalawa amatengedwa panthawi ya chakudya, ndiye kuti kuyamwa kwazomwe zimagwira kumachepa. Amadziunjikira makamaka m'makoma a chimbudzi chimbudzi.

Hafu ya moyo wake ndi pafupifupi maola 6.5. Mlingo wa bioavailability mwa anthu athanzi ndi 50-60%. Ndi mapuloteni a plasma, ubale wake ndiwofanana. Pafupifupi 20-30% ya mlingo amatuluka kudzera mu impso.

Zotsatira zoyipa

Nthawi zambiri, mukamamwa mankhwalawo, zotsatira zoyipa m'ntchito zake zimawonetsedwa m'mimba dongosolo: nseru kutsegula m'mimbakusanza, kupweteka m'mimba, kukulira kulakalakaMaonekedwe akununkhira achitsulo mkamwa. Monga lamulo, izi zimachitika nthawi yoyamba kumwa mankhwalawa. Nthawi zambiri, amachoka okha ndikugwiritsa ntchito mankhwalawa.

Ngati munthu ali ndi chidwi chachikulu ndi mankhwalawa, kukula kwa erythema ndikotheka, koma izi zimachitika pokha pokha. Ndi kukula kwa osowa mbali zotsatira - erythema - - ndikofunikira kuletsa phwando.

Ndi chithandizo chotenga nthawi yayitali, odwala ena amayamba kuwonjezeka chifukwa cha mayamwidwe. Vitamini B12. Zotsatira zake, kuchuluka kwake mu seramu kumachepa magazizomwe zimatha kubweretsa kuphwanya malamulo hematopoiesis ndi chitukuko megaloblastic anemia.

Mapiritsi a Metformin, malangizo (njira ndi mulingo)

Ndikofunikira kumeza miyala yonse ndikuwamwa ndi madzi ambiri. Amamwa mankhwalawo atatha kudya. Ngati nkovuta kwa munthu kumeza piritsi 850 mg, itha kugawidwa magawo awiri, omwe amatengedwa nthawi yomweyo, wina pambuyo pa mnzake. Poyamba, mlingo wa 1000 mg patsiku amatengedwa, mlingo uwu uyenera kugawidwa pawiri kapena katatu kuti mupewe mavuto. Pambuyo masiku 10-15, mlingo umakulitsidwa pang'onopang'ono. Kutalika kwakukulu kovomerezeka kwa 3000 mg ya mankhwala patsiku.

Ngati achikulire amatenga Metformin, ayenera kuyang'anira impso zawo nthawi zonse. Zochizira zathunthu zitha kupezeka pambuyo pa masabata awiri atayamba chithandizo.

Ngati ndi kotheka, yambani kumwa Metformin mutatha kumwa mankhwala ena a hypoglycemic, muyenera kusiya kaye kumwa mankhwalawa, kenako nkumayamba kumwa Metformin muyezo wanthawi yomweyo.

Ngati wodwalayo aphatikiza insulin ndi Metformin, ndiye kuti m'masiku angapo oyamba simuyenera kusintha mtundu wa insulin. Komanso, mlingo wa insulin ungachepetse pang'onopang'ono moyang'aniridwa ndi dokotala.

Mayendedwe Metformin Richter

Dokotala amakhazikitsa muyeso wa mankhwalawo, zimatengera shuga wamagazi a wodwalayo. Mukamamwa mapiritsi a 0,5 g, muyeso woyamba ndi 0,5-1 g patsiku. Kupitilira apo, mankhwalawa akhoza kuchuluka ngati pakufunika. Mlingo wapamwamba kwambiri patsiku ndi 3 g.

Mukamamwa mapiritsi a 0,85 g, muyeso woyamba ndi 0,85 g patsiku. Kupitilira apo, ngati kuli kotheka, kuwonjezera. Mlingo wapamwamba kwambiri ndi 2.55 g patsiku.

Kuchita

Zotumphukira za Metformin ndi sulfonylurea ziyenera kuphatikizidwa mosamala chifukwa choopsa cha hypoglycemia.

Mphamvu ya hypoglycemic imachepetsedwa mukamamwa glucocorticosteroids wambiri komanso wamba, glucagon, sympathomimetics, gestagens, adrenaline, mahomoni chithokomiro estrogenzotumphukira za nicotinic acid, thiazide okodze, phenothiazines.

Mukutenga Cimetidine Kuwonongeka kwa metformin m'thupi kumachepa, chifukwa, chiwopsezo cha chiwonetsero cha lactic acidosis chikukula.

Zotsatira za hypoglycemic zimatha kugwiritsidwa ntchito ndi β2-adrenoreceptor antagonists, angiotensin-converting factor inhibitors, clofibrate derivatives, monoamine oxidase inhibitors, non-steroidal anti-yotupa mankhwala ndi oxetetracycline, cyclophosphamidezotumphukira za cyclophosphamide.

Pogwiritsa ntchito intraarterial kapena intravenousasiyana mankhwala okhala ndi ayodini, omwe amagwiritsidwa ntchito pazowunikira za X-ray, limodzi ndi Metformin, wodwalayo amatha kukulitsa kulephera kwa aimpso, komanso kumawonjezera mwayi wa lactic acidosis. Ndikofunikira kuyimitsa phwando lisanachitike, panthawiyo komanso kwa masiku awiri pambuyo pake. Kuphatikiza apo, mankhwalawa amatha kubwezeretsedwanso ngati mawonekedwe a impso amawunikanso ngati abwinobwino.

Mukamamwa antipsychotic chlorpropamazine Mlingo wambiri, seramu shuga imachulukanso ndipo insulin imatulutsidwa. Zotsatira zake, kuchuluka kwa insulin kungakhale kofunikira. Koma izi zisanachitike, ndikofunikira kuti magazi anu azikhala ndi magazi.

Kupewa hyperglycemiasayenera kuphatikizidwa ndi Danazol.

Pogwiritsidwa ntchito kwa nthawi yayitali ndi metformin Vancomycin, Amilorida, Quinine, Morphine, Quinidine, Ranitidine, Cimetidine, Procainamide, Nifedipine, Triamterena plasma ndende ya metformin imawonjezeka ndi 60%.

Mayamwidwe a Metformin amachepetsa Guar ndi Cholestyramine, chifukwa chake, mutamwa mankhwalawa, kugwiritsa ntchito metformin kumachepa.

Imawonjezera mphamvu ya ma anticoagulants amkati, omwe ali m'gulu lamaphunziro.

Ma Analogs a Metformin

Ma anformes a Metformin ndi mankhwala osokoneza bongo Metformin Hydrochloride, Metformin Richter, Metformin teva, Bagomet, Forethine, Metfogamma, Glyformin, Metospanin, Siofor, Glycometer, Glycon, Vero Metformin, Orabet, Glyminfor, Glucophage, Novoformin. Palinso mankhwala angapo omwe ali ndi zotsatira zofananira (Glibenclamide etc.), koma ndi zida zina zogwira ntchito.

Kutenthetsa kwa Metformin

Ngakhale kuti bungwe la Metformin Richter ndi zinthu zina nthawi zambiri zimalandira ndemanga zokhudzana ndi Metformin kuti muchepetse thupi, chida ichi sichinapangidwe kuti chigwiritsidwe ntchito ndi anthu omwe akufuna kuchotsa kunenepa kwambiri. Mankhwalawa pakuchepetsa thupi amagwiritsidwa ntchito chifukwa cha zomwe zimachitika chifukwa chakuchepa kwa shuga wamagazi ndi kuchepa kwapakati pa thupi. Komabe, momwe mungatengere Metformin pakuchepetsa thupi kumatha kupezeka kuchokera kumagwero osadalirika pa netiweki, chifukwa akatswiri samalangiza kuchita izi. Komabe, kuchepetsa thupi ndi mankhwalawa nthawi zina kumakhala kotheka kwa iwo omwe amatenga Metformin kuchiza matenda a shuga.

Ndemanga za Metformin

Ndemanga za mapiritsi a Metformin kuchokera kwa odwala omwe ali ndi matenda osokoneza bongo akuwonetsa kuti mankhwalawa ndi othandiza ndipo amakupatsani mwayi wowongolera shuga. Maguluwa amafotokozanso za kusinthaku kwakuyenda bwino pochiritsidwa ndi mankhwalawa a PCOS. Koma nthawi zambiri pamakhala kuwunikiridwa ndi malingaliro a momwe mankhwalawo amachitikira Metformin Richter, Metformin teva ndipo ena amakulolani kuti muzilamulira thupi.

Ogwiritsa ntchito ambiri amati mankhwala okhala metforminadathandiziradi kuthana ndi mapaundi owonjezera. Koma nthawi imodzimodzi, zovuta zoyendetsedwa ndi m'mimba thirakiti zimawonetsedwa nthawi zambiri. Mukukambirana momwe metformin imagwiritsidwa ntchito pakuchepetsa thupi, malingaliro a madokotala amakhala osalimbikitsa. Amalangiza kwambiri kuti asazigwiritse ntchito pazifukwa izi, komanso kumwa mowa panthawi yamankhwala.

Mtengo wa Metformin, komwe mungagule

Mtengo Metformin muma pharmacies kutengera mankhwala ndi ma CD ake.

Mtengo Metformin teva 850 mg pafupifupi ma ruble 100 pa paketi 30 yama PC.

Kugula Metformin Canon 1000 mg (60 ma PC.) Ikhoza kukhala ya ma ruble 270.

Kuchuluka kwa Metformin, kutengera kuchuluka kwa mapiritsi omwe ali phukusi: 50 ma PC. Mutha kugula pamtengo wa ma ruble 210. Iyenera kukumbukiridwa mukamagula mankhwala ochepetsa thupi omwe amagulitsidwa ndi mankhwala.

Mlingo ndi makonzedwe

Mlingo wa Metformin umatsimikiziridwa ndi dokotala aliyense payekha, kutengera kuchuluka kwa shuga m'magazi, mapiritsi amatengedwa pakamwa, kwathunthu, panthawi yakudya kapena itangotha ​​kumene. Kuchepetsa chiopsezo cha mavuto kuchokera m'matumbo am'mimba, muyezo wa tsiku ndi tsiku umalimbikitsidwa kuti ugaledwe mu Mlingo wa 2-3.

Mlingo woyambirira nthawi zambiri umakhala 500-1000 mg patsiku, ngati kuli kofunikira (kutengera zotsatira za kutsimikiza kwa glucose m'magazi) atatha masiku 10-15, akhoza kuwonjezeka pang'onopang'ono. Mlingo wokonza mankhwalawa nthawi zambiri ndi 1500-2000 mg patsiku, pazipita tsiku lililonse sayenera kupitirira 3000 mg.

Odwala aukalamba akulimbikitsidwa kuti asatenge oposa 1000 mg patsiku.

Pazovuta zazikulu za metabolic, chifukwa chowonjezereka cha lactic acidosis, mlingo wa Metformin uyenera kuchepetsedwa.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo makonzedwe a mankhwala omwe ali ndi antipsychotic kapena danazole, komanso atamaliza maphunziro awo, amafunika kuwongolera glycemia komanso kusintha metformin ya mankhwala.

Tiyenera kukumbukira kuti akaphatikizidwa ndi metformin:

• Zotumphukira za Sulfonylurea, insulin, acarbose, mankhwala osokoneza bongo a anti-yotupa (NSAIDs), oxytetracycline, monoamine oxidase inhibitors (MAOs), cyclophosphamide, clofibrate zotumphukira, angiotensin kutembenuza enzyme inhibitors (ACEs), β-adrenergic
• Chlorpromazine - imathandizira muyezo waukulu (100 mg / tsiku) umakulitsa glycemia, kuchepetsa kutulutsa kwa insulin,
• Cimetidine - akuchedwa kuchotsedwa kwa metformin, potero amawonjezera ngozi ya lactic acidosis,
• Njira zakulera za pakamwa, glucocorticosteroids (GCS), epinephrine, glucagon, sympathomimetics, mahomoni a chithokomiro, zotumphukira za nicotinic acid, zotumphukira za phenothiazine, thiazide ndi loop diuretics zimachepetsa mphamvu ya hypoglycemic.

Metformin imachepetsa mphamvu ya ma anticoagulants (zotumphukira za coumarin).