Oxodoline (Oxodoline)

Dzinalo:Oxodoline

Kupanga ndi mawonekedwe a kumasulidwa

Mapiritsi Piritsi 1 ili ndi 50 mg ya chlortalidone.

Mu chithuza chomangira ma mapiritsi 50. Atakwezedwa m'makatoni.

Zachipatala ndi gulu la mankhwala

Gulu la Pharmacotherapeutic

Pharmacological zochita za mankhwala Oxodolin

Thiazide-ngati diuretic, imakhala ndi zotsatira zokhalitsa. Imasokoneza kubwezeretsanso kwa ayoni a sodium, chlorine ndi madzi ofanana mu zigawo za impso. Kuphatikiza apo, kumawonjezera kuyimitsidwa kwa potaziyamu, magnesium, bicarbonate ion kuchokera m'thupi, kuchedwa kwa excretion wa uric acid, calcium ion. Amakhala okongoletsa mphamvu kwambiri. Mphamvu ya diuretic imayamba pambuyo pa maola awiri, imafika pazowonjezera pambuyo pa maola 12 ndipo imatenga mpaka maola 72. Zimayambitsa kuchepa kwa kuthamanga kwa magazi. Mphamvu ya antihypertensive imayamba pang'onopang'ono, mpaka kufika patatha milungu iwiri. atayamba kulandira chithandizo. Kuphatikiza apo, chlortalidone imayambitsa kuchepa kwa polyuria kwa odwala omwe ali ndi matenda a shuga, ngakhale momwe amagwirira ntchito sanadziwike.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, chlortalidone imatenga gawo logaya chakudya. Mafuta sakhazikika. Amamangidwa ku maselo ofiira am'magazi mpaka kufika pamlingo wambiri, kumanga kwa mapuloteni a plasma sikutchulidwa kwenikweni.

T 1/2 kutalika, maola 40-60.

Imapakidwa makamaka mu mawonekedwe osasinthika ndi mkodzo.

Mwa odwala okalamba, chimbudzi chimachepetsedwa, poyerekeza ndi odwala azaka zapakati ndi zapakati, mayamwidwe sasintha.

II siteji CHF, ochepa matenda oopsa, chiwindi cirrhosis ndi portal matenda oopsa, nephrosis, nephritis, mochedwa.

Contraindication

Hypersensitivity (kuphatikizapo sulfonamide derivatives), hypokalemia, pachimake aimpso kulephera (anuria), hepatic chikomokere, pachimake hepatitis, matenda a shuga mellitus (mitundu yayikulu), gout, mkaka wauchifwamba. Kulephera kwamkati ndi / kapena chiwindi, matupi awo sagwirizana, mphumu ya bronchial, SLE.

Mlingo komanso njira yogwiritsira ntchito Oxodoline

Ikani payekha. Ndi ochepa matenda oopsa - 25 mg 1 nthawi / tsiku. Ngati ndi kotheka, mlingowo ukhoza kuwonjezeka mpaka 50-100 mg / tsiku. Atafika pachimake, amasintha kukonzanso mankhwala osakwanira muyezo wogwira. Ndi edematous syndrome, mlingo wa 50-100 mg umagwiritsidwa ntchito 1 nthawi / tsiku, ngati kuli kotheka, mpaka 200 mg, atatha kukwaniritsa, amasintha kuti akonze mankhwala.

Zotsatira zoyipa

Kuchokera m'mimba: kutheka mseru, kusanza, kutsegula m'mimba, kudzimbidwa, kusowa chilimbikitso.

Kuchokera kumbali ya chapakati mantha dongosolo ndi zotumphukira mantha dongosolo: mutu, kufooka, paresthesia, chizungulire ndikotheka.

Kuchokera pamiyala yamagetsi yamagetsi: Hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia ndizotheka.

Kuchokera kumbali ya kagayidwe: Hyperuricemia, hyperglycemia.

Kuchokera ku hemopoietic system: kawirikawiri - thrombocytopenia, leukopenia.

Dermatological zimachitika: zotupa za khungu ndizotheka.

Mimba komanso kuyamwa

Imalowa mkati mwa chotchinga chachikulu. Pa mimba contraindicated ochepa ochepa matenda oopsa. Nthawi zina, kugwiritsa ntchito kumatheka pokhapokha pokhapokha ngati pali chithandizo chokwanira komanso ngati phindu la mankhwalawo limaposa chiwopsezo cha mwana wosabadwayo.

Chlortalidone imapukusidwa mkaka wa m'mawere. Ngati ndi kotheka, gwiritsani ntchito mkaka wa m'mawere, yoyamwitsa iyenera kutha.

Kugwiritsa ntchito kwa chiwindi kuwonongeka ntchito Contraindicated kwambiri chiwindi kulephera. Gwiritsani ntchito mosamala ngati vuto la kuwonongeka kwa impso likuwonekera.

Gwiritsani ntchito odwala okalamba

Gwiritsani ntchito mosamala okalamba.

Malangizo apadera olembetsa Oxodoline

Munthawi yamankhwala, ndikofunikira kudziwa ma electrolyte amwazi, makamaka kwa odwala omwe akukonzekera digito. Sitikulimbikitsidwa kupereka mankhwala okhwima kwambiri opanda mchere kwa odwala. Ngati pali zizindikiro za hypokalemia (myasthenia gravis, kusokonezeka kwa mitsempha) kapena ngati odwala ali ndi mwayi wowonjezera wa K + kutaya (ndi kusanza, kutsegula m'mimba, kuperewera kwa zakudya m'thupi, cirrhosis, hyperaldosteronism, chithandizo cha ACTH, GCS), chithandizo chamankhwala cha K + chikuwonetsedwa. Odwala omwe ali ndi hyperlipidemia, ma seramu lipids amayenera kuyang'aniridwa pafupipafupi (ngati kuwonjezeredwa kwawo kwamankhwala, chithandizo chikuyenera kusiyidwa). Ndi thiazide diuretics, kufalikira kwa SLE kunadziwika. Ngakhale zochitika ngati izi sizinadziwike ndi chlortalidone, kusamala kuyenera kuchitika popereka mankhwala kwa odwala omwe ali ndi SLE.

Kuchita ndi Mankhwala Ena

Pogwiritsa ntchito munthawi yomweyo corticosteroids, amphotericin B, carbenoxolone, chiopsezo chokhala ndi hypokalemia yowonjezereka chikuwonjezeka.

Pogwiritsa ntchito munthawi yomweyo ndi ma NSAIDs, kuchepa kwa okodzetsa ndi antihypertensive zotsatira za chlortalidone ndikotheka.

Pogwiritsa ntchito munthawi yomweyo kukonzekera kwa digito, ndizotheka kuwonjezera chiopsezo cha zotsatira zoyipa za kukonzekera kwa digito chifukwa cha hypokalemia chifukwa cha chlortalidone.

Pogwiritsa ntchito munthawi yomweyo lifiyamu ya carbonum, kuchuluka kwa maamu m'magazi am'magazi komanso chiopsezo cha kuchuluka kwa kuledzera.

Kugwiritsa ntchito mankhwala Oxodolin pokhapokha ngati adokotala adafotokoza, mafotokozedwewo amaperekedwa kuti awathandize!

Kodi ndi ziti zomwe mungazindikire kuti munthu amayamba kudwala matenda amisala?

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, chlortalidone imatenga gawo logaya chakudya. Mafuta sakhazikika. Amamangidwa ku maselo ofiira am'magazi mpaka kufika pamlingo wambiri, kumanga kwa mapuloteni a plasma sikutchulidwa kwenikweni.

T 1/2 kutalika, maola 40-60.

Imapakidwa makamaka mu mawonekedwe osasinthika ndi mkodzo.

Mwa odwala okalamba, chimbudzi chimachepetsedwa, poyerekeza ndi odwala azaka zapakati ndi zapakati, mayamwidwe sasintha.

Zizindikiro zamankhwala

Zotsatira zoyipa

Kuchokera pamimba: kukhumudwa, kusanza, kutsegula m'mimba, kudzimbidwa, kusowa kwa chakudya kumatheka.

Kuchokera kumbali ya chapakati mantha dongosolo ndi zotumphukira mantha dongosolo: mutu, kufooka, paresthesia, chizungulire n`zotheka.

Pa gawo la madzi-electrolyte bwino: hypokalemia, hypomagnesemia, hyponatremia, hypochloremic alkalosis, hypercalcemia ndizotheka.

Kuchokera kumbali ya kagayidwe: hyperuricemia, hyperglycemia.

Kuchokera pa hemopoietic dongosolo: kawirikawiri - thrombocytopenia, leukopenia.

Zokhudzana ndi zovuta: zotupa za khungu ndizotheka.

Mimba komanso kuyamwa

Imalowa mkati mwa chotchinga chachikulu. Pa mimba contraindicated ochepa ochepa matenda oopsa. Nthawi zina, kugwiritsa ntchito kumatheka pokhapokha pokhapokha ngati pali chithandizo chokwanira komanso ngati phindu la mankhwalawo limaposa chiwopsezo cha mwana wosabadwayo.

Chlortalidone imapukusidwa mkaka wa m'mawere. Ngati ndi kotheka, gwiritsani ntchito mkaka wa m'mawere, yoyamwitsa iyenera kutha.

Malangizo apadera

Amagwiritsidwa ntchito mosamala odwala matenda a shuga, omwe ali ndi gout, kwambiri atherosclerosis ya coronary ndi chotupa cha mitsempha, mkhutu wamisempha wa impso, okalamba.

Panthawi ya chithandizo, ndikofunikira kuwongolera chithunzi cha magazi, mawonekedwe a electrolyte m'magazi, kuchuluka kwa uric acid, glucose m'magazi.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Chlortalidone, makamaka kumayambiriro kwa chithandizo, imatha kufooketsa kuyendetsa magalimoto ndikugwiritsa ntchito makina.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo corticosteroids, amphotericin B, carbenoxolone, chiopsezo chokhala ndi hypokalemia yowonjezereka chikuwonjezeka.

Pogwiritsa ntchito munthawi yomweyo ndi ma NSAIDs, kuchepa kwa okodzetsa ndi antihypertensive zotsatira za chlortalidone ndikotheka.

Pogwiritsa ntchito munthawi yomweyo kukonzekera kwa digito, ndizotheka kuwonjezera chiopsezo cha zotsatira zoyipa za kukonzekera kwa digito chifukwa cha hypokalemia chifukwa cha chlortalidone.

Pogwiritsa ntchito munthawi yomweyo lifiyamu ya carbonum, kuchuluka kwa maamu m'magazi am'magazi komanso chiopsezo cha kuchuluka kwa kuledzera.

Kupanga ndi mawonekedwe a kumasulidwa

mu paketi yoyambirira ya ma PC 10., mumapaketi okhala ndi makatoni 5 kapena kapu yagalasi yamdima ya ma PC 50., mumtundu wa makatoni 1 mtsuko.

Mankhwala

Imalepheretsa kugwiranso ntchito kwa mafuta a sodium ion (Na +), makamaka mu zotumphukira za impso tubules (gawo lozungulira la Henle loop), kukulitsa chimbudzi cha sodium ions (Na +), chlorine ion (Cl -) ndi madzi. Kutupa kwa potonium ion (K +) ndi ma magnesium ion (Mg 2+) kudzera mu impso kumawonjezeka, pomwe chimbudzi cha calcium ions (Ca 2+) chikuchepa.

Zimayambitsa kutsika pang'ono kwa kuthamanga kwa magazi, kuopsa kwa hypotensive zotsatira kumawonjezeka pang'onopang'ono ndikuwonetseredwa mokwanira masabata awiri atatha chithandiziro chitayamba.

Kumayambiriro kwa zamankhwala, zimayambitsa kuchepa kwakukulu kwa kuchuluka kwa madzi akunja kwama cell, BCC, ndi voliyumu yamagazi, komabe, patatha milungu ingapo yogwiritsa ntchito, zizindikirozi zimabwereranso pamlingo woyandikira koyambirira.

Monga thiazide diuretics, amachititsa kuchepa kwa polyuria mwa odwala a impso shuga insipidus.

Kuyamba kwa kuchitapo kanthu ndi maola 2 - 2 pambuyo pakumeza, mphamvu yayitali ndikutatha maola 12, kutalika kwa masiku ndi masiku atatu.

Contraindication

Hypersensitivity (kuphatikizapo sulfonamide zotumphukira),

kukula kwapang'onopang'ono mitundu ya nephrosis ndi nephritis ndi kuchepa kwa glomerular kusefera mlingo,

pachimake aimpso kulephera ndi anuria,

hepatic chikomokere, pachimake chiwindi,

shuga mellitus (mitundu yayikulu),

zosokoneza pamiyeso yamagetsi yamagetsi,

ana ochepera zaka 18 (mphamvu ndi chitetezo sizinakhazikitsidwe).

Impso ndi / kapena kulephera kwa chiwindi,

systemic lupus erythematosus,

Zotsatira zoyipa

Kuchokera m'mimba: nseru, kusanza, matenda am'mimba, kudzimbidwa kapena kutsekula m'mimba, intrahepatic cholestasis, jaundice, kapamba.

Kuchokera ku dongosolo lamanjenje: chizungulire, paresthesia, asthenia (kutopa kwachilendo kapena kufooka), kusokoneza, kusayang'anira.

Kuchokera pamalingaliro: kuwonongeka kwa mawonekedwe (kuphatikizapo xanthopsia).

Mbali ya magazi ndi ziwalo zopanga magazi: thrombocytopenia, leukopenia, agranulocytosis, eosinophilia, aplastic anemia.

Kuchokera pamtima: orthostatic hypotension (imatha kuwonjezeka motsogozedwa ndi ethanol, anesthetics, mankhwala osokoneza bongo), arrhythmia (chifukwa cha hypokalemia).

Zizindikiro zasayansi: Hypokalemia, hyponatremia (kuphatikiza ndi zizindikiro zamitsempha - nseru), hypomagnesemia, hypochloremic alkalosis, hypercalcemia, hyperuricemia (gout), hyperglycemia, glucosuria, hyperlipidemia.

Zotsatira zoyipa: urticaria, photosensitivity.

Zina: kuphipha kwa minofu, kuchepa kwa potency.

Kuchita

Zimawonjezera kuchuluka kwa ma lithiamu ion (Li +) m'magazi (momwe Li + imayambitsa polyuria, imatha kukhala ndi zotsutsana) ndipo, motero, imawonjezera chiopsezo cha kuledzera ndi mankhwala a Li +.

Imawonjezera mphamvu ya ma curariform minyewa omaliza komanso antihypertensive mankhwala (kuphatikiza guanethidine, methyldopa, beta-blockers, vasodilators, BKK), MAO zoletsa.

Ndikumamwa glycosides wamtima, imatha kukulitsa mtima wake chifukwa cha kuledzera kwa digito.

Hypokalemic mphamvu ya mankhwalawa amathandizidwa ndi concomitant makonzedwe a GCS, amphotericin, carbenoxolone.

NSAIDs imafooketsa hypotensive ndi okodzetsa mphamvu ya mankhwala.

Potengera zakumayambiriro kwa kugwiritsa ntchito chlortalidone, kuwongolera (kuwonjezeka kapena kuchepa) kwa mlingo wa insulin kapena kuwonjezeka kwa mlingo wa mankhwala amkamwa hypoglycemic angafunikire

Mlingo ndi makonzedwe

Mkati (nthawi zambiri m'mawa, asanadye chakudya cham'mawa). Mlingo amasankhidwa payekha, kutengera kuopsa kwa chikhalidwe ndi matendawo zomwe zimapezeka. Ndi chithandizo chotenga nthawi yayitali, tikulimbikitsidwa kupereka mankhwala ochepetsa mphamvu yokwanira (oyenera odwala okalamba).

Ndi ochepa matenda oopsa - 50 mg kamodzi pa tsiku katatu pa sabata.

Ndi edematous syndrome: Mlingo woyambirira ndi 100 mg tsiku lililonse tsiku lililonse (Mlingo pamwamba pa 100 mg nthawi zambiri samayambitsa kukokoloka), mankhwalawa akukwanira 100-120 mg tsiku 3 katatu pa sabata.

Ndi aimpso mawonekedwe a shuga insipidus: mlingo woyambirira ndi 100 mg 2 kawiri pa tsiku, kukonzanso mlingo ndi 50 mg patsiku.

Bongo

Zizindikiro chizungulire, mseru, kugona, Hypovolemia, kuchepa kwambiri kwa magazi, kukomoka, kukhumudwa.

Chithandizo: gastric lavage, kuperekedwa kwa makala ophatikizika, mankhwala othandizira (kuphatikizapo iv kulowetsedwa kwa njira zamchere kuti mubwezeretse magazi mu magazi).

Zotsatira za pharmacological

Zimawonjezera kukakamiza kwa kugwiranso ntchito kwa ma sodium ion, makamaka mu zotumphukira zaimpso, kuwonjezera kuchuluka kwa chlorine, sodium ndi ayoni amadzi. Kukula kwa calcium ions kudzera mu impso kumachepa, ndipo ma ions a magnesium ndi potaziyamu amawonjezeka.

Zimayambitsa kuchepa pang'ono kwa kukakamiza. Kukula kwa hypotensive zotsatira kumawonjezeka pang'onopang'ono, ndikudziwonekera mokwanira pakatha milungu iwiri kapena inayi atayamba chithandizo.

Zimayambitsa kuchepa kwamphamvu kwa miniti yamagazi, BCC ndi voliyumu ya madzi akunja, koma zotere zimachitika pokhapokha pakuyamba chithandizo. Pambuyo pa milungu ingapo, zizindikirazi zimatenga mtengo wofanana ndi woyambayo.

Monga thiazide diuretics, amathandizira kuchepetsa polyuria mwa odwala aimpso insipidus.

Mankhwalawa amayamba kuchita pakatha maola awiri kapena anayi atamwa. Kuchuluka kwake kumatheka pambuyo maola khumi ndi awiri. Kutalika kwa zochita kumasiyana masiku awiri kapena atatu.

Mafuta - 50% mu maola 2.6. Bioavailability ndi 64 peresenti. Kuphatikiza kwa mapuloteni a Plasma ndi 76 peresenti. Pambuyo kumwa mankhwalawa mlingo wa 100 kapena 50 mg, Cmax imafikiridwa pambuyo pa maola 12 ndipo ndi 16.5 ndi 9.4 mmol / L, motsatana.

Kutha kwa theka moyo kumasiyana 40 mpaka 50 maola. Imayatsidwa osasinthika ndi impso. Imadutsa mkaka wa m'mawere. Mukhoza kudziunjikira matenda aimpso kulephera.

Zizindikiro zogwiritsidwa ntchito

Oxodolin amalembedwa kuti:

• yade, nephrosis,
• ochepa matenda oopsa
• matenda a chiwindi ndi portal matenda oopsa,
• digiri yotsika ya mtima II,
• dysproteinemic edema,
• aimpso mawonekedwe a shuga insipidus,
• kunenepa.

Kuphatikizika, mawonekedwe omasulidwa

Amapezeka mu mawonekedwe a mapiritsi oyera. Tinge yachikasu imaloledwa. Mapiritsiwo amayikidwa mumitsuko yamgalasi yakuda kapena matuza, kenako m'mabokosi amakalata.

Chosakaniza chophatikizira mu oxodoline ndi chlortalidone. Zothandiza monga: mbatata, shuga mkaka (lactose), calcium stearic acid (calcium stearate), ochepa molekyulu polyvinylpyrrolidone.

Migwirizano, nthawi yosungirako

Pamalo ozizira, otetezedwa ku kuwala.

Masiku ano ndizovuta kupeza Oxodolin m'mafakitala aku Russia, chifukwa chake sikotheka kunena za mtengo wa mankhwalawo.

Ogulitsa mankhwala osokoneza bongo a ku Oksodolin sazindikira.

Mankhwala otsatirawa ndi ma synylms a mankhwalawa: Gigroton, Urandil, Edemdal, Hydronal, Isoren, Oradil, Renon, Urofinil, Apochlortalidon, Chlortalidone, Chlorphthalidolone, Famolin, Igroton, Natriuran, Phthalamidine, Saluretin, Zambezil.

Kutengera ndi malingaliro, munthu akhoza kuweruza kuwonjezeka kwa Oxodoline. Odwala omwe ali ndi matenda oopsa amalekerera bwino mankhwala.

Kuwona kwa madotolo omwe adauza mankhwalawo kwa odwala awo kumatsimikizira izi.

Zosafunika zimachitika kawirikawiri, zimadziwika chifukwa chakufooka. Malinga ndi madokotala, Oxodolin ndi yoyenera kuchira kwakanthawi.

Onani zowunikira zenizeni kumapeto kwa nkhaniyo. Gawani malingaliro anu zokhudzana ndi Oxodoline ngati mwalandira kapena mwalamula.

Mankhwala

Mankhwala
Wothandizila wothandizila. Imalepheretsa kugwiranso ntchito kwa sodium ion (Na +), makamaka mu zotumphukira za impso tubules (gawo lozungulira la Henle loop), kukulitsa chimbudzi cha Na +, chlorine ions (SG) ndi madzi. Kutupa kwa potonium ion (K +) ndi ma magnesium ion (Mg 2+) kudzera mu impso kumawonjezeka, pomwe chimbudzi cha calcium ions (Ca 2+) chikuchepa. Zimayambitsa kuchepa pang'ono kwa kuthamanga kwa magazi (BP), kuopsa kwa mphamvu ya pang'onopang'ono kumawonjezeka ndipo kumawonekera kwathunthu patatha masabata awiri atatha chithandizo.
Kumayambiriro kwa zamankhwala, zimayambitsa kuchepa kwakukulu kwa kuchuluka kwa madzi akunja, kuchuluka kwa magazi ndi magazi a miniti, komabe, patatha milungu ingapo kugwiritsa ntchito, zizindikirozi zimabwereranso pamlingo wapafupi ndi wapachiyambi.
Monga thiazide diuretics, amachititsa kuchepa kwa polyuria mwa odwala a impso shuga insipidus.
Kuyamba kwa kuchitapo kanthu ndi maola 2-4 atatha kumwa, kuchuluka kwake kumachitika pambuyo pa maola 12, kutalika kwa masiku ndi masiku awiri ndi atatu.

Pharmacokinetics
Mafuta - 50% kwa maola 2.6. Bioavailability ndi 64%. Pambuyo pakukonzekera kwa pakamwa 50 mg ndi 100 mg, kuphatikiza kwakukulu kumafikiridwa pambuyo maola 12 ndipo ndi 9.4 ndi 16.5 mmol / L, motsatana. Kuyankhulana ndi mapuloteni a plasma - 76%.
Kutha kwa theka-moyo ndi maola 40-50. Amatulutsidwa ndi impso zosasinthika. Imalowa mkaka wa m'mawere. Kulephera kwa aimpso, kumatha kudziunjikira.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Ndi chithandizo chotenga nthawi yayitali, tikulimbikitsidwa kupereka mankhwala ochepetsetsa kwambiri okwanira kukhalabe ndi zotsatira zabwino, makamaka odwala okalamba.

Ndi ochepa matenda ochepa ochepa - 25 mg kamodzi patsiku kapena 50 mg katatu pa sabata, ngati kuli kotheka, kuchuluka kwa mlingo mpaka 50 mg / tsiku ndikotheka.

Ndi edematous syndrome, mlingo woyambirira ndi 100-120 mg tsiku lililonse, m'malo ovuta kwambiri, 100-120 mg / tsiku kwa masiku ochepa oyambira (Mlingo pamwamba pa 120 mg nthawi zambiri samayambitsa kuwonjezeka kwa diuretic effect), ndiye kuti ndikofunikira kusintha kwa mlingo wokonzanso wa 100- 50-25 mg / tsiku katatu pa sabata.

Renal shuga insipidus (mu akulu): mlingo woyambirira ndi 100 mg 2 kawiri pa tsiku, mlingo wokonza ndi 50 mg patsiku.

Mlingo wamba wa ana tsiku lililonse ndi 2 mg / kg.