Ofloxin imapezeka mu mawonekedwe a mapiritsi a biconvex ozungulira oyera oyera opanda zodetsa ndi fungo. Mapiritsiwa amakhala ndi zokutira ndipo ali ndi chiopsezo chogawana. Kutengera ndi kipimo, zolemba zimapezeka mbali imodzi "200"Kapena"400". Pa kink - kukanikizidwa woyera misa.

Matuza a Contour cell aikidwa pabokosi lamakadi.

Paketi iliyonse iyenera kukhala ndi malangizo atsatanetsatane ogwiritsira ntchito mankhwalawa.

Pharmacodynamics ndi pharmacokinetics

Ofloxacin Ndiwothandizira antimicrobial wokhala ndi mawonekedwe osiyanasiyana a bactericidal kanthu. Ndiye wa m'gululi. chimfine. Ofloxacin imathandizira kwambiri pa puloteni ya DNA yotchedwa encyme, yomwe imapereka DNA yapamwamba kwambiri. Mankhwalawa amathandizira kuti pakhale ma CD, omwe amatsogolera ku kufa kwa tizilombo.

OfloxacinIli ndi ntchito yayikulu yolimbana ndi ma tizilombo tating'onoting'ono timene timatulutsa β-lactamases, komanso imagwiritsidwa ntchito kuthana ndi microsacteria yomwe ikukula mwachangu ngati Enterobacteriaceae (Salmonella, Serratia, Citrobacter, Klebsiella, Yersinia), Escherichia coli, Enterobacter spp., Shigella spp., Providencia spp., Proteus spp.

Mankhwala nawonso amagwira ntchito motsutsana staphylococcus (kuphatikizapo penicillin wopanga ndi ma methicillin oletsa kugonjetsedwa (Chlamydia trachomatis, Chlamydia chibayo, Mycoplasma chibayo, Mycobacterium chifuwa chachikulu cha Mycobacterium leprae, Ureaplasma urealyticum).

Mankhwalawa akuwonetsanso zotsatira zabwino pochiza matenda oyambitsidwa ndi ma microbacteria otsatirawa: Pasteurella multocida, Pseudomonas spp., Brucella melitensis, Haemophilus influenzae, Campylobacter sp., Neisseria meningitidis, Branhamella catarrhalis, Vibrio sp., Pseudomonas aeruginosa.

Ndikofunika kugwiritsa ntchito mankhwalawa pogwiritsa ntchito kubereka mwachangu. Helicobacter pylori, Acinetobacter sp., Neisseria gonorrhoeae, Haemophilus ducreyi, Gardnerella vaginalis.

Ofloxin sakhala yogwira motsutsana ndi matenda opatsirana omwe amayambitsidwa ndistreptococci ya gulu A, B, C. Komanso anaerobes, kupatula Clostridium perfringens. Muzochitika izi, ofloxacin imakhala yochepa kwambiri ndipo, ngati zingatheke, ndibwino kugwiritsa ntchito mankhwala ena kuti achepetse njira zolerera za mabakiteriya.

Mabakiteriya a Anaerobic samveranso chidwi ndi mankhwalawo Fusobacterium spp., Bacteroides spp., Peptococcus spp., Ndipo Peptostreptococcus spp.

Ofloxin sagwira ntchito mogwirizana Treponema pallidum.

Zogulitsa

Mukamamwa mankhwalawa, mayamwidwe amakhala athunthu (95%) komanso mwachangu. Bioavailability amaposa 96%. Сmax pamene mukumwa mankhwala Mlingo wa 100 mg, 300 mg ndi 600 mg ukufika 1 mg / l, 3,4 mg / l ndi 6.9 mg / l, motsatana. Ndi muyezo umodzi wa mankhwalawa muyezo wa 200 mg ndi 400 mg, Cmax imafika ku 2.5 μg / ml ndi 5 μg / ml. Tiyenera kudziwa kuti kudya kwambiri kumachepetsa kuyamwa, koma sikukukhudza kwambiri bioavailability.

Kugawa

Kumangidwa kwa ofloxacin ndi mapuloteni a plasma ndi 20-25%. Vd yemwe akuwonekerayo amafikira 100 malita.
Mankhwalawa amalowerera mosavuta m'madzimadzi ambiri amthupi ndi ziwonetsero zamadzimadzi (zamkati ndimatumbo amkati, mkodzo, malovu, chinsinsi cha bronchial, ndi zina zotere) Ofloxacin imalowanso mwaulere wa chotchinga ndi BBB, ndikufotokozedwanso mkaka wa m'mawere. Kulowetsa kwa mankhwalawa mu madzi amchere kumasiyana pakati pa 14 mpaka 60%. Ofloxacin sachitapo kanthu.

Kupenda

Kupenda amapezeka m'chiwindi. Dimethylofloxacin ndi ofloxacin N-oxide amapangidwa.

Kuswana

T1 / 2 pakaperekedwa pakamwa, ngakhale mlingo, umachotsedwa pambuyo pa maola 4.5-7. Excretion imagwiritsidwa ntchito ndi impso (75-90%) ndi bile (4%). Kuchotsa zowonjezera kuli pafupifupi 20%. Odwala omwe ali ndi vuto laimpso kapena kwa hepatic ayenera kukumbukira kuti T1 / 2 ya mankhwalawa imawonjezeka. Ndi mlingo umodzi wa 200 mg, ofloxacin amatha kupezeka mu mkodzo mkati mwa maola 20-24.

Zizindikiro zogwiritsidwa ntchito

Ofloxin adadzitsimikizira pochiza:

• kwambiri kupuma thirakiti matenda (matenda a bronchiectatic, chotupa cha m'mapapo,chibayo),
• Matenda a ENT (atitis media, sinusitis, pharyngitis, laryngitis / kupatula pachimake tonsillitis /),
• matenda a mafupa ndi mafupa,
• minofu yofewa ndi khungu,
• matenda opatsirana komanso otupa a m'mimba (m'mimba, matenda amtundu wa biliary / kupatula bacteric enteritis /),
• matenda a impso (pyelonephritis),
• matenda a kwamkodzo thirakiti (urethritis, cystitis),
• matenda amchiberekero (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• matenda oyamba a ziwalo zoberekera (orchitis, colpitis, epididymitis, chinzonono, prostatitis),
• meningitis,
• chlamydia,
• matenda ophatikizika ndi Zida,
• matenda amaso (conjunctivitis, zilonda zam'magazi za cornea, blepharitis, dacryocystitis, meibomite, keratitis).

Ofloxin imagwiritsidwanso ntchito:

• popewa matenda opatsirana pambuyo pakuchita opaleshoni yokhudzana ndikuchotsa thupi lakunja kapena kuvulala kwamaso.
• ndi zovuta mankhwala chifuwa chachikulu,
• popewa matenda odwala chitetezo chokwanira (neutropenia).

Contraindication

Muyenera kukana kutenga Ofloxin:

• at shuga-6-phosphate dehydrogenase akusowa,
• at khunyu (kuphatikiza mbiri),
• atkutsitsa khomo lolanda (kuphatikizapo pambuyo sitiroko, kuvulala kumutu kapena njira iliyonse yotupa mkati mwa dongosolo lamanjenje.

• anthu osakwana zaka 18
• anthu omwe ali ndi hypersensitivity ku zigawo za mankhwala.
• azimayi oyembekezera
• Azimayi nthawi yoyamwa.

Mosamala, mankhwalawa amayenera kugwiritsidwa ntchito mwa anthu omwe ali ndi matenda omwe amayambitsidwa ndi kufalikira kwa ziwindi ndi matenda amiseche. At aakulu aimpso kulephera ndi organic zotupa za chapakati mantha dongosolo Ndikofunika kusankha mankhwala othandizira omwe ali ndi mawonekedwe ofananawo, koma osakhala owopsa.

Zotsatira zoyipa

Panthawi ya chithandizo ndi Ofloxin, wodwalayo akhoza kusasangalala komanso kudwala:

• Wolemba chimbudzi: mseru, kusanza, kutsegula m'mimba, kusokonezeka kwa m'mimba, kupweteka kwam'mimba(kuphatikiza gastralgia), kuwonjezera ntchito ya hepatic transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.
• Wolemba zotumphukira zamanjenje dongosolo ndi CNS:Mutu, chizungulire, kusayenda bwino, kunjenjemera, kukokana, dzanzi ndi zolimbitsa miyendo, maloto akulu, zolota, zosokoneza bongo, kuda nkhawa,kusakhazikikaphobias, kukhumudwa, chisokonezo, kuyerekezera zinthu zinakuchuluka kwazovuta zamkati.
• Wolemba ziwalo zam'malingaliro: zovuta zamtundu wamtundu, diplopia,Kusokonezeka kwa kukoma, kumva, kununkhira komanso kusamala.
• Wolemba mtima: tachycardia, vasculitis, kugwa.
• Wolemba musculoskeletal system: tendonitis, myalgia, arthralgia, tendosynovitis, kupindika kwa tendon.
• Wolemba machitidwe hematopoietic: leukopenia, agranulocytosis, kuchepa magazi, thrombocytopenia, pancytopenia, hemolytic ndi aplastic anemia.
• Wolemba kwamikodzo machitidwe: pachimake interstitial nephritis, mkhutu aimpso ntchito, hypercreatininemia,kuchuluka kwa urea.
• Zotsatira zoyipa:zotupa pakhungu, kuyabwa, urticaria, chifuwa chachikulu, chifuwa chachikulu, kuchepa kwa magazi, kutentha kwa magazi, Quincke's edema, bronchospasm, Stevens-Johnson syndrome, matenda a Lyell, photosensitivity, erythema multiforme, anaphylactic.
• Dermatological zimachitika: hemorrhages (petechiae), a hemorrhagic dermatitis, papular zotupa, vasculitis.
• Ndiponso: dysbiosis, superinfection, hypoglycemia(mwa odwala matenda ashuga), vaginitis.

Malangizo ogwiritsa ntchito mankhwala aloxine (njira ndi mulingo)

Chifukwa chakuti Ofloxin amagwiritsidwa ntchito pochiza matenda osiyanasiyana, mulingo wa mankhwalawa umasankhidwa payekhapayekha ndipo zimangotengera kuuma komanso malo omwe wodwalayo ali nawo. Malangizo a Ofloxin 400 mg ayenera kuthandizidwa makamaka pakugwira ntchito ya chiwindi ndi impso.

Akuluakulu amakwaniritsidwa mlingo wa 200 mg kawiri pa tsiku, kapena 400 mg 1 nthawi patsiku. Mlingo waukulu patsiku suyenera kupitirira 800 mg. Njira ya chithandizo imatsimikiziridwa ndi kudziwa kwa tizilombo toyambitsa matenda ndipo nthawi zambiri ndi masiku 7-10. Tengani mankhwalawa makamaka m'mawa 30-60 asanadye. Imwani mapiritsi ndi madzi ochepa.

Musanayambe kumwa mankhwalawa, muyenera kufunsa dokotala, chifukwa mlingo wa mankhwalawa matenda osiyanasiyana umatha kusiyanasiyana.

Kuchita

Mukamamwa mankhwala mkati, muyenera kukumbukira kuti amachepetsa kuyamwa ofloxacinzopangidwa ndi zakudya zomwe zimakhala ndi calcium, aluminiyamu, magnesium, komanso mchere wamchere, chifukwa amapanga zovuta kuzinthu zina. Iyenera kuwonetsetsa kuti kusinthanitsa pakati pa utsogoleri wa Ofloxin ndi zinthu izi ndi pafupifupi maola 2.

Phwandoofloxacin25% yachepetsedwa chilolezo cha theophylline Ndipo ndikofunika motere kuchepetsa mlingo theofylline.

Makamaka chidwi chake chikuyenera kuperekedwa kwa mankhwala omwe amachotsa secretion wa tubular, popeza makonzedwe awo munthawi yomweyo ndi Ofloxin angakulitse kwambiri kuchuluka kwa ofloxacin mu plasma.

Kusintha Glibenclamide mu plasma kumadaliranso Ofloxin.

Ofloxin sayenera kumwedwa mavitamini a vitamini K, chifukwa izi zitha kusintha mkhalidwewo dongosolo la magazi.

Zothandiza nitroimidazolendi methylxanthinestikamatenga pamodzi zimatha kuyambitsa chitukuko machitidwe a neurotoxic, ndi GKS kumawonjezera chiopsezo cha kuphulika kwa tendon, komwe kumakhala koopsa kwambiri kwa okalamba.

Kutenga ofloxin ndi mankhwala omwe amachititsa kuti mkodzo ugwire kungayambitse chiwopsezo cha kukula ndi chitukuko nephrotoxic zotsatirandikhalid.

Tsiku lotha ntchito

Ofloxin ali ndi alumali moyo wazaka zitatu.

Pakadali pano, Ofloxin ali ndi chifanizo pafupifupi 20 kuchokera kwa omwe amapanga zapakhomo ndi zakunja. Mankhwala otchuka kwambiri masiku ano ndi awa: Zanocin, Ofloxacin, OflocidndiLoflox.

Zofanizira zina zomwe zimagwira ntchito ndi: Vero Ofloxacin, Glaufos, Danzil, Uniflox, Phloxal.

Ndemanga za Ofloxine

Zolemba za Ofloxin pamabwalo zimasiyana kuchokera pa 1 mpaka 5 pamlingo wa 5-point.

Tatha kuwunikira ndemanga za alendo opezeka ku magulu azachipatala, titha kunena kuti odwala omwe adalandira chithandizo chokwanira adakhutira kwathunthu ndi zotsatira zake. Zambiri zotsika za mankhwalawa nthawi zambiri zimaperekedwa ndi alendo omwe Ofloxin adakumana ndi zovuta kwambiri. Nthawi zambiri, pamabwalo, odwala amadandaula za kupweteka kwambiri m'mimba, kuchepa kwamtimamawonekedwe kukhumudwa, ulesi, kugona ndipo ngakhale usikukuyerekezera.

Kodi ofloxin ndi antiotic kapena ayi?

Zokambirana zambiri pamabwalo zimaperekedwa pankhaniyi. Ndipo akatswiri amapereka yankho lomveka bwino kuti Ofloxin ndi mankhwala amphamvu osokoneza bongo, ndipo alangizeni odwala omwe ali ndi mankhwalawa amadzetsa vuto losankha mankhwala ochepera poyerekeza ndi mankhwala.

Palibe chidziwitso pa mankhwala Ofloxin pa Wikipedia.

Ofloxacin

Mitengo muma pharmacose apaintaneti:

Ofloxacin ndi mankhwala antimicrobial osiyanasiyana maselo a bactericidal kanthu. Zili pagulu la fluoroquinolones.

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa amasankhidwa payekhapayekha, potengera momwe wodwalayo alili, impso ndi chiwindi.

Mapiritsi okhala ndi mbali

Mapiritsiwo anapangidwira pakamwa pakamwa musanadye kapena nthawi ya chakudya. Amayenera kumezedwa lonse, osafuna kutafuna, otsukidwa ndi madzi.

Mlingo wovomerezeka kwa akuluakulu ndi 200-800 mg patsiku 2 waukulu. Kutalika kwa chithandizo ndi masiku 7-10. Ngati mlingo wa tsiku ndi tsiku sunapitirire 400 mg, mutha kutumikiridwa mu mlingo umodzi, makamaka m'mawa.

Mu chinzonono chachikulu, Ofloxacin amagwiritsidwa ntchito pa mlingo wa 400 mg kamodzi.

Kulowetsedwa njira

Njira yothetsera vutoli imaperekedwa.

Mlingo woyambirira wa Ofloxacin ndi 200 mg kudzera mkati mwa mphindi 30-60. Thupi la wodwalayo likamayenda bwino, amalipereka kwa mankhwala mkati momwemonso tsiku lililonse.

• Matenda a ziwalo zoberekera ndi impso - 100-200 mg kawiri pa tsiku,
• Matenda amitsempha yam'mimba - 100 mg 1-2 patsiku,
• Matenda a Septic ndi matenda a ziwalo za ENT, kupumira, kupuma kwam'mimba, minofu yofewa ndi khungu, mafupa ndi mafupa - 200 mg kawiri pa tsiku (ngati kuli kotheka, onjezani mlingo mpaka 400 mg 2 kawiri pa tsiku),
• Kupewa matenda opatsirana omwe ali ndi vuto la chitetezo - 400-600 mg patsiku.

Ngati matenda aimpso ayambitsidwa ndi vuto la creatinine chilolezo cha 20-50 ml / min), muyezo umodzi uyenera kuchepetsedwa ndi 50% ya muyezo wa mankhwalawa (ngati mankhwalawa amwedwa kawiri pa tsiku) kapena mlingo umodzi wokhazikika uyenera kuperekedwa, koma 1 kamodzi patsiku. Ndi creatinine chilolezo chosakwana 20 ml / mphindi, limodzi mlingo ndi 200 mg, kenako 100 mg patsiku lililonse tsiku lililonse.

Ndi peritoneal dialysis ndi hemodialysis, Ofloxacin ndi mankhwala 100 mg maola 24 aliwonse.

Ndi kulephera kwa chiwindi, mlingo waukulu patsiku ndi 400 mg.

Kwa ana omwe ali ndi matenda oopsa, mankhwalawa amadziwitsidwa muyezo wa tsiku ndi tsiku wa 7.5 mg / kg, ndi mlingo waukulu wa 15 mg / kg.

Kutalika kwa mankhwalawa kumatengera kuzindikira kwa pathogen komanso chithunzi cha matenda. Chithandizo chimapitilizidwa kwa masiku ena atatu kuchokera kutha kwa zizindikiro za matenda osachiritsika otupa komanso matenda a kutentha kwa thupi. Ndi matenda a kwamikodzo osavuta, njira ya mankhwalawa ndi masiku 3-5, ndi salmonellosis - masiku 7-8.

Mafuta

Mafuta a Ofloxacin amagwiritsidwa ntchito mopangika. Mankhwalawa amaikidwa pachikuto cha m'maso chakukhudzidwa (mzere wamafuta 1 cm, womwe umafanana ndi 0.12 mg ofloxacin) katatu patsiku. Ndi matenda a chlamydial, mankhwalawa amagwiritsidwa ntchito 5-6 patsiku.

Njira ya mankhwalawa sapitirira milungu iwiri (matenda a chlamydial amafuna chithandizo chotalikilapo - kuyambira milungu 4 mpaka 5).

Malangizo apadera

Ofloxacin si mankhwala osankhidwa a chibayo chifukwa cha chibayo. Sanapangire zochizira pachimake tonsillitis.

Mankhwalawa, kuwongolera dzuwa mwachindunji ndi magetsi a UV (mabedi owotcha, nyali za mercury-quartz) ziyenera kupewedwa.

Kupitilira miyezi iwiri yogwiritsa ntchito mankhwalawa osavomerezeka.

Pankhani ya thupi lawo siligwirizana ndi zotsatira zoyipa kuchokera chapakati mantha dongosolo, Ofloxacin ziyenera kusiyidwa. Ndi pseudomembranous colitis yotsimikizika, pakamwa pa metronidazole ndi vancomycin tikulimbikitsidwa.

Ngati zizindikiro za tendonitis zikuchitika, chithandizo chiyenera kuimitsidwa pomwepo, pambuyo pake a Achilles tendon ayenera kuyimitsidwa ndipo opaleshoni ya mafupa ayenera kuthandizidwa.

Amayi samalimbikitsidwa kugwiritsa ntchito ma tamponi ngati ma tampon panthawi yamankhwala, chifukwa pali chiopsezo chachikulu chotukula vagidi candidiasis.

Pogwiritsa ntchito Ofloxacin, zotsatira zabodza zopanda pake zimatha kukhala ndi njira yodziwira matenda a chifuwa chachikulu.

Odwala odziwikiratu nthawi yomwe amamwa mankhwala ndi mankhwala, zovuta za porphyria komanso kuwonjezeka kwa maphunziro a myasthenia ndizotheka.

Odwala omwe ali ndi vuto la kuwonongeka kwa impso kapena kwa chiwindi, plasma ndende yaloloacacin iyenera kuyang'aniridwa. Kulephera kwambiri kwa hepatic kapena aimpso, chiopsezo cha zotsatira za poizoni ndichopitirira.

Pa mankhwala, mowa uyenera kupewedwa.

Muubwana, Ofloxacin amagwiritsidwa ntchito pokhapokha ngati pali chiopsezo ku moyo ndipo ndizosatheka kugwiritsa ntchito ena, omwe si oopsa. Pankhaniyi, kuchuluka kwa mapindu omwe akuyembekezeredwa ndi chiwopsezo cha zotsatira zoyipa ziyenera kulingaliridwa.

Panthawi yamankhwala, ndikofunika kupewa kuchita nawo zinthu zoopsa komanso kuyendetsa.

Mukamagwiritsa ntchito mafuta a Ofloxacin, magalasi ofewa sayenera kuvala. Chifukwa cha chitukuko cha Photophobia, timalimbikitsidwa kugwiritsa ntchito magalasi osagonja ndikuwala nthawi yayitali.

Mafuta sayikidwa jekeseni m'chipinda chamkati cha diso kapena subconjunctivally.

Kuyanjana kwa mankhwala osokoneza bongo

Ofloxacin imawonjezera kuchuluka kwa glibenclamide mu madzi am'magazi, kumachepetsa chilolezo cha theophylline ndi 25%.

Tubular katulutsidwe kutsekereza mankhwala, furosemide, cimetidine ndi methotrexate kumawonjezera plasma ndende yaloloacacin.

Ndi munthawi yomweyo kugwiritsa ntchito methylxanthines ndi nitroimidazole, ndi mankhwala omwe si a antiidal a antiidal, mwayi wokhala ndi vuto la neurotoxic ukuwonjezeka.

Mukaphatikizidwa ndi glucocorticosteroids, chiwopsezo cha kutukuka kwa tendon chimawonjezeka, makamaka kwa okalamba.

Ma citrate, carbonic anhydrase inhibitors ndi sodium bicarbonate amawonjezera chiopsezo cha nephrotoxic zotsatira ndi crystalluria.

Ndi munthawi yomweyo makonzedwe a antioxidant osagwirizana a vitamini K, ndikofunikira kuyan'ana mkhalidwe wamagetsi oyambitsa magazi.

Yankho la Ofloxacin limagwirizana ndi njira ya Ringer yothetsera vutoli, 5% shuga (dextrose) yankho, isotonic NaCl yankho ndi 5% fructose solution.

Mukamagwiritsa ntchito mankhwalawa ngati mafuta amodzimodzi nthawi yomweyo ndi mafuta ena am'maso / madontho, nthawi yochepera mphindi 15 iyenera kuchitika, pomwe Ofloxacin amagwiritsidwa ntchito komaliza.

Kupanga ndi mawonekedwe a kumasulidwa

Ofloxacin ndi yogwira mankhwala aloxacin, mankhwala amapangidwa monga:

1. Njira yothetsera kulowetsedwa, mtundu wachikasu wonyezimira, 1 ml womwe uli ndi 2 mg wa chigawo chachikulu. Zinthu zina ndi: sodium chloride, disodium edetate dihydrate, moyikirapo hydrochloric acid, madzi d / ndi. Mankhwala amagulitsidwa mu Mlingo wa 100 ml mu milozo zamagalasi zopanda utoto,
2. Mapiritsi, ophimbidwa ndi filimu yoyera, biconvex yozungulira, zomwe zili ndi mulingo wa 400 kapena 200 mg. Zothandiza zothandizira: poloxamer, wowuma chimanga, crospovidone, magnesium stearate, talc, lactose monohydrate, povidone. Kuphatikizika kwa chipolalachi kumaphatikizapo: titanium dioxide, macrogol, talc, hypromellose. Wogulitsidwa mumapiritsi 10 kapena 7 m'matumba am'melo, ma contour mapaketi. 1 kapena 2 mapaketi mabokosi.

Gulu la Clinical ndi pharmacological: antibacterial mankhwala a gulu la fluoroquinolone.

Chifukwa chiyani Ofloxin adalembedwa?

Ofloxin adadzitsimikizira pochiza:

• matenda a mafupa ndi mafupa,
• minofu yofewa ndi khungu,
• matenda a impso (pyelonephritis),
• matenda amkodzo thirakiti (urethritis, cystitis),
• meningitis
• chlamydia
• Matenda okhudzana ndi Edzi
• matenda a m'chiberekero zamkati (endometritis, salpingitis, cervicitis, parametritis, prostatitis),
• matenda okhudzana ndi maliseche (orchitis, colpitis, epididymitis, gonorrhea, prostatitis),
• matenda opatsirana ndi otupa a m'mimba (matenda am'mimba, thirakiti la biliary / kupatula kwa bakiteriya enteritis /),
• kwambiri kupuma thirakiti matenda (bronchiectasis, mapapo abscess, chibayo),
• matenda a ziwalo za ENT (otitis media, sinusitis, pharyngitis, laryngitis / kupatula kwa pachimake tonsillitis /),
• matenda a maso (conjunctivitis, zilonda zam'mimba zotupa, blepharitis, dacryocystitis, meibomite, keratitis).

Ofloxin imagwiritsidwanso ntchito:

• popewa matenda opatsirana pambuyo pakuchita opaleshoni yokhudzana ndikuchotsa thupi lakunja kapena kuvulala kwamaso.
• ndi zovuta mankhwala a chifuwa chachikulu,
• popewa matenda odwala immunodeficiency (neutropenia).

Mlingo

200 mg, 400 mg mapiritsi okhala ndi mafilimu

Piritsi limodzi lili

ntchito yogwira - ofloxacin 200 mg, 400 mg,

zokopa: mbatata wowuma, lactose monohydrate, microcrystalline cellulose, povidone K30, sodium wowuma glycolate, magnesium kapena calcium stearate, calcium carboxymethyl cellulose

kapangidwe ka chipolopolo: polyethylene glycol 6000, titanium dioxide (E 171), hypromellose 2910.

Mapiritsi okutidwa, kuyambira oyera mpaka otsekemera mu utoto, woboola kapisozi, wokhala ndi chizindikiro komanso cholemba, mbali inayo zoopsa ndi kalata "G", inayo - chiwerengero "200" - pamlingo wa 200 mg.

Mapiritsi okutidwa, kuyambira oyera mpaka otsekemera mu utoto, woboola kapiso, wokhala ndi chilembo komanso chosanja, mbali imodzi ngozi ndizolemba "G", mbali inayo - manambala "400" pa mlingo wa 400 mg.

Mankhwala

Pharmacokinetics

Mafuta pambuyo kumeza mwachangu komanso mwathunthu. Kuzindikira kwakukulu mu plasma ya magazi kumatheka mkati mwa maola 1-3 mutatha kamodzi kwa 200 mg. Kutha kwa theka-moyo ndi maola 4-6 (ngakhale mutamwa).

Polephera aimpso, mlingo uyenera kuchepetsedwa.

Palibe kuyanjana kwakukulu ndi chakudya komwe kunapezeka.

Mankhwala

Ofloxacin ndi antibacterial mankhwala a gulu la quinolone, omwe ali ndi bactericidal. Njira yayikulu yogwirira ntchito ndiyo kusokoneza kwenikweni kwa puloteni ya michere ya DNA gyrase. Mapulogalamu ena a DNA gyrase ndi omwe amaphatikizanso kufalitsa, kupanga, kukonza, kukonza. Kuletsa kwa michere ya DNA gyrase kumatsogolera pakukutitsa ndi kufalitsa kwa bakiteriya ndipo kumayambitsa kufa kwa ma cell mabakiteriya.

Antibacterial chiwonetsero cha chidwi cha tizilombo tosokoneza bongo toloxacin.

Ma tizilombo tating'ono tomwe timayang'ana ku ofloxacin: Staphylococcusaureus(kuphatikiza ndi methicillinStaphylococci),Staphylococcuskhungu,Neisseriamitundu,Esherichiacoli,Cikonokomacter,Klebsiella,Enterobacter,Hafnia,Proteus(kuphatikiza indole-positive ndi indole-negative),Haemophilusfuluwenza,Chlamydie,Legionella,Gardnerella.

Ma microorganic omwe ali ndi kuthekera kosiyanasiyana kwa ofloxacin: Streptococci,Serratiamarcescens,PseudomonasaeruginosandiMycoplasmas.

Ma Microorganisms kugonjetsedwa (osasangalatsa) kwa ofloxacin: mwachitsanzo Mabakiteriyamitundu,Eubacteriummitundu,Fusobacteriummitundu,Peptococci,Peptostreptococci.

Mlingo ndi makonzedwe

Ofloxacin iyenera kukhazikitsidwa pamaziko a maphunziro a microbiological ndikuwunika kuzindikira kwa tizilombo.

Mlingo umatengera mtundu ndi kuuma kwa matendawa, komanso kuzindikira kwa tizilombo komanso chiwindi ndi impso.

Kwa odwala akuluakulu, mlingo wa mankhwalawa ndi 200 - 800 mg patsiku.

Mlingo wofika mpaka 400 mg patsiku umatha kutumikiridwa mu 1 piritsi, makamaka m'mawa, mlingo waukulu umagawidwa pawiri. Mwambiri, aliyense payekha Mlingo uyenera kumwedwa mosiyanasiyana.

Matenda ochepa a kwamikodzo

Mlingo wamba wabwinobwino ndi 200 mpaka 400 mg wa ofloxacin Upper kwamikodzo matenda

Mlingo wamba wabwinobwino ndi 400 mg yaloxacin patsiku, ndikuchulukitsa mpaka 400 mg kawiri tsiku lililonse, ngati pakufunika.

Matenda ochepetsa kupuma thirakiti

Mlingo wamba wa aliyense ndi 200 mpaka 400 mg waloxacin patsiku, ndikuchulukitsa mpaka 400 mg kawiri pa tsiku, ngati kuli kotheka.

Unreompral urethral ndi cervical gonorrhea

Mlingo umodzi wa 400 mg.

Non-neococcal urethritis ndi cervicitis

Mlingo umodzi wa 400 mg, womwe ungagawidwe pawiri.

Matenda opatsirana a pakhungu ndi minofu yofewa

Mlingo wamba wabwinobwino ndi 400 mg ofloxacin kawiri tsiku lililonse.

Odwala ndi mkhutu aimpso ntchito

Kwa odwala omwe ali ndi vuto la aimpso, Mlingo womwe uli pansipa ulimbikitsidwa:

Mlingo umodzi, mg *

Pafupipafupi kumwa mankhwalawa patsiku

Kuyimitsa pakati pakulandila, h

Palibe kusintha kwa mlingo kofunikira

50 - 20 ml / mphindi (serum creatinine 1.5-5.0 mg / dl)

Zotsatira za pharmacological

Mankhwala a antimicrobial fluoroquinolone Ofloxin ndiwowoneka mosiyanasiyana, mapiritsiwo ali ndi mphamvu ya bactericidal, ndiye kuti, amatsogolera ku imfa ya bakiteriya wa pathogenic. Ndilembapo zomwe ma tizilombo opanga mankhwala opangira mankhwala amagwira ntchito motere: Salmonella spp, Brucella spp, Chlamydia spp, Yersinia enterocolitica, Enterococcus faecalis, Proteus spp, Vibrio cholerae, Serratia marcescens, Haemophiluseronfesserendendendendendendendendendeliwooquendendendendendendeyakumenekukumanakumenekumasanja. Campylobacter jejuni, Aeromonas hydrophila, Bordetella pertussis.

Kuphatikiza apo, mankhwalawa amagwira mabakiteriya oterewa: Staphylococcus aureus, Citrobacter spp, Gardnerella vaginalis, Mycobacterium tuberculosis, Mycoplasma pneumoniae, Staphylococcus epidermidis, Streptococcus pyogene, Mycoplasma hominis, Acinetobacter sppxlera , Neisseria meningitidis, Escherichia coli, Clostridium perfringens, Bordetella parapertussis, Listeria monocytogene, Shigella spp, Helicobacter pylori, Ureaplasma urealyticum, Vibrio parahaemolyticus, Haemophilus influenzae, Hafniap.

Mutatha kumwa Ofloxin, imakamizidwa ndi 95%, pafupifupi gawo limodzi la mankhwalawo ndi bioavailability wa mankhwalawo. Kumanga mapuloteni ndi 25%. Ofloxacin amalowa muzinthu zina zamthupi, komanso m'misempha yambiri. Siziunjikira (sichisonkhanitsa). Hafu ya moyo wa mankhwalawa imatha mpaka maola asanu ndi awiri. Wopangidwira m'chiwindi. Zosasinthika, zotulutsidwa mkodzo.

Malangizo okonza

Mlingo waloxacin amatsimikiziridwa payekha ndi adotolo, kutengera kuopsa kwa matendawa ndi mtundu wa matenda opatsirana.

Ofloxacin wa kulowetsedwa: limodzi mlingo wa 200-400 mg (1-2 mabotolo) 2 r / s ndi imeneyi maola 12 (kwa akulu omwe ali ndi vuto laimpso). Pakulephera kwa impso, pomwe creatinine chilolezo choposa 50 ml / min, kusintha kwa mlingo sikofunikira. Ndi chilolezo cha 20-50 ml / mphindi, 200 mg amagwiritsidwa ntchito muyezo woyambira, kenako 100 mg / tsiku. Ndi chilolezo chochepera 20 ml / min, ntchito muyezo wa 200 mg, ndiye 100 mg kamodzi pakapita masiku awiri. Ndi kulephera kwa chiwindi, mlingo sapitilira 400 mg / tsiku. Njira yothetsera kulowetsedwa imaperekedwa kudzera mu mtsempha wa magazi kwa theka la ora.

Ndikusintha kwazomwe zikuchitika komanso zotsatira zabwino za mankhwalawo, kulowetsedwa kumaloledwa ndi mkati mwa gawo lomweli. Kutalika kwa mankhwalawa ndi masiku 7-10.

Mimba komanso kuyamwa

Kugwiritsa ntchito mankhwala Ofloxacin pa nthawi ya pakati ndi contraindicated.

Chifukwa Chifukwa chakuti forloxacin imadutsa mkaka wa m'mawere, kugwiritsa ntchito Ofloxacin Zentiva kumakhudzana ndi chiopsezo cha mwana. Ngati ndi kotheka, kugwiritsidwa ntchito kwake kuyenera kusankha pakuletsa kuyamwitsa.

Kuchita mankhwala osokoneza bongo

Ofloxacin amalowerera kwambiri akamadyedwa muzakudya zomwe zimakhala ndi calcium, potaziyamu ndi magnesium yambiri. Chifukwa chake, pakati pakudya ndi zinthu izi ndi mankhwalawa zimatenga pafupifupi maola awiri.

Mankhwala omwe amatchinga katulutsidwe ka tubular, limodzi ndi Ofloxin, amathandizira kuchuluka kwa chinthu chachikulu mu plasma. Chifukwa chake, kugwiritsa ntchito ndalama zotere kuyenera kuchitika mosamala. Ofloxin 200 wophatikiza ndi vitamini K ali ndi vuto la kupangika kwa magazi.

Musamamwe mankhwalawa nthawi yomweyo monga mkodzo wamchere. Izi zimatha kudzetsa crystallization ndi nephrotoxic.

Ofloxin analogues

Zofanana muzochitika zamagulu:

• Vero Ofloxacin,
• Glaufos,
• Danzil
• Zanocin,
• Zoflox,
• Ofo,
• Oflox
• Ofloxabol,
• Ofloxacin
• Ofloxin 200
• Oflomac,
• Oflocid,
• Oflocide Forte
• Tarivid
• Tariferide
• Taritsin,
• Uniflox
• Phloxal.

Chidwi: kugwiritsa ntchito ma fanizo kuyenera kuvomerezana ndi adokotala.

Mtengo wapakati wa OFLOXACIN, mapiritsi mumafakisi (Moscow) ma ruble 200.

Malo osungira

Sungani zaka zopitilira 3 m'malo owuma, kutali ndi kuwala, pamtunda wa 10-25 ° C. Njira yothetsera kulowetsedwa sikuletsedwa kuzizira.

Nditha kunena kale kuti ndili ndi vuto la cystitis kuyambira ubwana wanga, motero ndimadziwa kale machiritso onse a cystitis. Koma ofloxin adandiuza kwa urologist miyezi inayi yokha yapitayo ndipo adalimbikitsa kuti ndi mankhwala amphamvu komanso othandiza. Zachidziwikire, ndidadutsa njira yonse yomwe ndikudziwira, koma nthawi yonseyi sindinkakhala bwino, ndinali ndi kusintha kosintha, zakudya zonse zimalawa ngati choko, ndiye kuti sindingathe kuyambiranso mankhwalawa.

Mankhwala abwino. Ndinkamwa zakumwa ku prostatitis, zidakhala zosavuta kangapo, koma pokhapokha ngati zidavuta. M'malo mwake, pamene matendawa aphedwa, ndiye kuti kutupa kumachoka mwachangu.

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