Mphamvu yogwira ya Amoxil ndi amoxicillin trihydrate. Amoxicillin ndi aminopenicillin wopanga yemwe ali ndi bactericidal katundu koma samvera tinthu tating'onoting'ono tomwe timatulutsa penicillinase, komanso kwa ena.

Amoxil imakhala ndi clavulanic acid, yomwe imapangitsa kuti ikhale yolimba ndi penicillinase, imachepetsa chitetezo chokwanira kwa antimicrobial.

Zowonetsa kugwiritsa ntchito Amoxil

Malinga ndi malangizo, Amoxil ndi omwe amapatsidwa matendawa:

• matenda am'mimba thirakiti ndi hepatobiliary system,
• matenda a impso ndi kwamkodzo
• matenda a minofu, mafupa,
• minofu yofewa komanso khungu.

Amoxil imathandizira pamavuto opatsirana pambuyo pakuchita opaleshoni.

Kuphatikiza ndi hlalithromycin kapena metronidazole, Amoxil amagwiritsidwa ntchito pochiza zilonda zam'mimba zam'mimba, gastritis yokhazikika.

Contraindication

• kusalolera kwa mankhwala, komanso maantibayotiki ena okhala ndi penicillin. Ndi chidwi chambiri ku cephalosporin Maantibayotiki ayenera kudziwa kufunikira kwa chifuwa,
• lymphocytic leukemia ndi matenda mononucleosis,
• ana osakwana chaka chimodzi
• Nthawi yonyamula mkaka.

Zotsatira zoyipa

Thupi lawo siligwirizana mu kuyabwa, urticaria, malungo, Hyperemia, Matenda a Stevens, Hyperkeratosis, epidermal necrolysis, chikangawankhaza dermatitis, angioedema, vasculitis, matenda a seramu, anaphylactic mantha.

Tizilombo toyamwa: Kuchepa kwa chakudya, nseru, pakamwa kowuma, kusanza, kutsekula m'mimba, chisangalalo, colitis, kusintha kwa michere ya chiwindi kumtunda, hepatitis ndi jaundice.

Machitidwe amanjenje: kusowa tulo, kuda nkhawa, kugona. chizungulire, Hyperkinesismutu. Ndi kuwonongeka kwa ntchito ya impso, pamakhala kukhudzidwa.

Hematopoietic ziwalo:thrombocytopenia, leukopenia, hemolytic anemia, kuchuluka kwa prothrombin index.

Njira yamikodzo: yolowera yade.

Mwa zina, kuphatikiza mphamvu kumatha kuchitika, candidiasis mucous nembanemba, kufooka kwathunthu, zabodza zimachitika pakutsimikiza shuga mu mkodzo ndi urobilinogen.

Malangizo ogwiritsira ntchito Amoxil (Njira ndi Mlingo)

Ikani mapiritsi monga adanenera adotolo, ngakhale zakudya.

Mlingo wa matenda oletsa kuponderezana:

• achikulire ndi ana atatha zaka 10 - 500-750 mg kawiri pa tsiku,
• ana kuyambira zaka 3 mpaka 10 za 750 mg patsiku 3 Mlingo wogawika,
• kuyambira chaka chimodzi mpaka 3 250 mg kawiri pa tsiku.

Ngati mukudwala matenda obwereza komanso ovuta kwambiri, akulu amatenga 3 ga patsiku, ana amatenga 60 mg / kg yolemera, magawo atatu.

Mlingo wa tsiku ndi tsiku wa akulu ndi 6 g.

Njira ya mankhwalawa imapitilizanso masiku ena atatu atachira Zizindikiro. Matenda ofooka pang'ono amakhala ndi njira ya chithandizo cha sabata limodzi. Ngati muli ndi matenda a beta-hemolytic streptococcus, mankhwala osachepera masiku 10.

Zochizira pachimake zovuta chinzonono zotchulidwa kamodzi 3 g kuphatikiza kufufuza kuchuluka kwa 1 g.

Ndi zilonda zam'mimba zothetsa Helicobacter pylori Malangizo a Amoxil 500 mg amapereka njira zomwe zimayenera kuperekedwa pamodzi ndi mankhwala ena:

• Amoxil 2 g patsiku awiri Mlingo wogawika limodzi chindwan 500 mg kawiri pa tsiku komanso omeprazole Mlingo wa 40 mg pa tsiku.
• Amoxil 2 g patsiku ndi metronidazole 400 mg katatu patsiku ndi omeprazole 40 mg patsiku.

Njira ya mankhwala 1 sabata.

Pakulephera kwa aimpso, zimayikidwa poganizira kuchuluka kwa kusefedwa kwa msana ndi mulingo wa chilolezo creatinine.

Kuchita

Mapiritsi a Amoxil mukamamwa ndi njira zakulera zam'mlomo zimatha kuchepetsa mphamvu zakulera komanso zimapangitsa kuti magazi azituluka.

Pogwiritsa ntchito munthawi yomweyo ndi phenenicide, phenylbutazone, sulfinperazone, indomethacin ndi acetylsalicylic acid Kuchotsa Amoxil ndi impso kumachepetsa.

Mankhwala omwe ali ndi bacteriostatic zotsatira (chloramphenicol, macrolides, machez) athetse zotsatira za Amoxil.

Kugwiritsa ntchito ndi allopurinol kuwonjezera mwayi woti khungu siligwirizana.

Nthawi yomweyo maantacid amachepetsa mayamwidwe Amoxil.

Kuphatikiza ndi anticoagulants kumawonjezera mwayi wokhetsa magazi, kotero muyenera kuwongolera chizindikiro cha nthawi ya prothrombin.

Kutsegula m'mimba amachepetsa kuyamwa kwa mankhwalawa.

Mwa amayi apakati, mankhwalawa amachepetsa ndende estradiol mkodzo.

Malangizo apadera

Kuthekera kopanga ziwonetsero zamaanti ofiira a cephalosporin ndi penicillin ayenera kusiyidwa musanayambe chithandizo.

Kugwiritsidwa ntchito mobwerezabwereza komanso kwa nthawi yayitali kumabweretsa kukula kwa kukana komanso kupambanitsidwa.

Kusungunula ndi kutsegula m'mimba kumachepetsa kuyamwa kwa mankhwalawa, pazikhalidwe izi siziyenera kufotokozedwa.

Gawani mosamala kwa odwala mphumu ndi matupi awo sagwirizana.

Kumwa mankhwalawa muyezo waukulu kumayambitsa chitukuko khalid, motero, kupewa, ndikofunikira kumwa madzi okwanira.

Mankhwalawa amatha kusintha mtundu wa enamel wa dzino mu ana, chifukwa chake muyenera kuyang'anira ukhondo wa mano ndi pakamwa.

Ndi anaphylactic mantha, mawonekedwe owumba a m'mapapo amachitika, kutumikiridwa epinephrinekutsatira antihistamines, glucocorticoids ndi mpweya.

Pa mimba ndi mkaka wa m`mawere

Ngati ndi kotheka, kuchuluka kwa mapindu kwa mayi ndi kuopsa kwa mwana wosabadwayo kuyenera kuyesedwa.

Mphamvu ya Amoxil ya teratogenic sichinadziwikebe.

Pochepa, mankhwalawa amapezeka mkaka wa m'mawere. Kuwapatsa mkaka wa m`mawere ndikotheka, koma tikulimbikitsidwa kusiya kuyamwitsa panthawi ya mankhwalawa pofuna kupewa kukhudzidwa.

Ndemanga za Amoxil

Kuwerenga ndemanga za Amoxil, mutha kuwonetsetsa kuti mankhwalawa ndi okwera mtengo komanso ogwira ntchito. Malingaliro abwino ambiri pakugwiritsa ntchito bronchitis, chibayo ndi tonsillitisonse akulu ndi ana. Odwala omwe adagwiritsa ntchito mankhwalawa adawona kuchira msanga.

Palinso ndemanga zabwino za mcheyama ndi zotupa zina za pustular khungu.

Choyipa chake ndikuwoneka mwa ena mwa odwala omwe ali ndi vuto lakhansa pakhungu kapena m'matumbo.

Ubwino wake ndikuti chifukwa cha chitetezo, mapiritsi a Amoxil amaloledwa kugwiritsidwa ntchito woyembekezera ndi unamwino.

Mlingo ndi makonzedwe

Kutsatira malangizowo, Amoxil imayendetsedwa kulowetsedwa komanso mkamwa.

Kulowetsedwa (intravenous) ukuchitika mu mtsinje kapena kukapanda kuleka ndi maola 8-12. Amoxil yothetsera imayendetsedwa atangophatikizidwa ndi ufa ndi pambuyo osasungidwa.

Achire ambiri achire a Amoxil kwa akuluakulu ndi 1000/1 mg mg ndi gawo la maola 8. Mlingo wololedwa wambiri ndi 100/20 mg ndi gawo la maola 6.

Panthawi yopangira opaleshoni, muyezo umodzi wa Amoxil 1000/1 mg umathandizidwa pamaso pa opaleshoni, kenako muyezo uliwonse maola asanu ndi limodzi.

Mankhwalawa ana, Amoxil amagwiritsidwa ntchito mwanjira zina: mpaka miyezi itatu. (masekeli mpaka 4 kg) imayendetsedwa kamodzi 25/5 mg pa kilogalamu ya kulemera kulikonse maola 12. Kuyambira miyezi itatu. mpaka malita 12 (wolemera kuposa makilogalamu 4) amathandizidwa ndi 25/5 mg pa kilogalamu imodzi ndi maola 8

Kutenga mapiritsi a Amoxil sikugwirizana ndi kudya, ayenera kumezedwa lonse. Mapiritsi a Amoxil amatengedwa ndi gawo la maola 8.

Malinga ndi malangizo Amoxil ana zotchulidwa motere: 1-2 zaka - 30 mg pa tsiku pa kilogalamu ya kulemera. Kuyambira 2 mpaka 5 malita. - 125mg nthawi. Kuyambira malita 5-10. - 250 mg nthawi. Ndi 10l. (ndi thupi lolemera kuposa 40 makilogalamu) - 250-500 mg nthawi. Mlingo wapamwamba wa ana a Amoxil m'mapiritsi ndi 60 mg pa kilogalamu patsiku.

Mapiritsi a akulu a Amoxil amapereka 250-500 mg. Woopsa - 1g.

Mlingo

250 ndi 500 mg mapiritsi

Piritsi limodzi lili

ntchito yogwira: amoxicillin trihydrate, mwa amoxicillin - 250 mg kapena 500 mg,

zokopa: sodium wowuma glycolate, povidone, calcium stearate.

Mapiritsi ndi oyera ndi tachikasu tende, lathyathyathya-cylindrical wokhala ndi bevel ndi notch.

Mankhwala

Pharmacokinetics.

Zogulitsa. Pambuyo pakukonzekera kwa pakamwa, amoxicillin amalowetsedwa m'matumbo ang'ono mofulumira komanso pafupifupi kwathunthu (85-90%). Kudya mothandizirana sikukhudza kuperewera kwa mankhwalawa. Pambuyo pa kumwa kamodzi pa 500 mg, kuchuluka kwa amoxicillin m'madzi a m'magazi anali 6-11 mg / L. Pazipita ndende yogwira mafuta a m'magazi amatheka pambuyo pa maola 1-2.

Kugawa. Pafupifupi 20% ya amoxicillin imamangiriza mapuloteni a plasma. Amoxicillin amalowa mucous nembanemba, minofu mafupa, intraocular madzimadzi ndi sputum mu achire ogwira woipa. The kuchuluka kwa mankhwalawa mu bile amapitilira ndende yake m'magazi ndi 2-4. Amoxicillin amabwera bwino mu madzi a cerebrospinal, komabe, ndi kutupa kwa mangesing (mwachitsanzo, ndi meningitis), ndende ya madzi am'magazi ndi pafupifupi 20% ya ndende ya madzi a m'magazi.

Kupenda. Amoxicillin imapangidwa pang'ono, ma metabolites ake ambiri samagwira.

Kuswana. Amoxicillin amapukusidwa makamaka ndi impso. Pafupifupi 60-80% ya mlingo wotengedwa umachotsedwa pambuyo maola 6 osasinthika. Hafu ya moyo wa mankhwalawa ndi maola 1-1,5. Ndi vuto laimpso, theka la moyo wa amoxicillin limakulirakulira ndikufika maola 8.5 ndi anuria.

Hafu ya moyo wa mankhwalawa sasintha ngati chiwindi chayamba kugwira ntchito.

Mankhwala

Amoxicillin ndi mankhwala opangidwa ndi aminopenicillin ochulukitsa othandizira pakamwa. Imachepetsa kapangidwe ka khoma la bakiteriya. Ili ndi mitundu yosiyanasiyana yokhudzana ndi antimicrobial.

Mitundu yotsatirayi ya tizilombo tating'ono imakhudzidwa ndi mankhwalawa:

- zoyipa zamagetsi: Corinebacterium diphteriae, Enterococcus faecalis, Listeria monocytogene, Streptococcus agalactiae, Streptococcus bovis, Streptococcus pyogene,

- zoyipa zamagalamu: Helicobacter pylori,

Mankhwala amakhudzidwa mosiyanasiyana: Corinebacterium spp., Enterococcus faecium, Streptococcus pneumoniae, Streptococcus viridans, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Proteus mirabilis, Prevotella, Fusobacterium spp.

Mitundu yolimba monga: Staphylococcus aureus, Acinetobacter, Choprobacter, Enterobacter, Klebsiella, Legionella, Morganella morganii, Proteus vulgaris, Providencia, Pseudomonas, Serratia, Bacteroides fragilis, Chlamidia, Mycoplasma, Ratchtsia.

Zizindikiro zogwiritsidwa ntchito

- matenda opuma

- chakudya cham'mimba (kuphatikiza ndi metronidazole kapena clarithromycin chimagwiritsidwa ntchito pochiza matenda ogwirizana ndi Helicobacter pylori)

- matenda a pakhungu ndi minyewa yofewa yomwe imayambitsidwa ndi ma microorganices omwe amamva mankhwala

MALANGIZO

mankhwala

dіyucha rechovina: amoxicillin,

Piritsi 1 kubwezera amoxicillin trihydrate, ngati bongo wa amoxicillin - 250 mg kapena 500 mg,

mawu owonjezera: sodium wowuma, calcium, calcium owonda.

Fomu la Likarska. Mapiritsi

Gulu la Pharmacotherapeutic. Ma penicillin osiyanasiyana dії.

Khodi ya PBX J01C A04.

Zowonetsedwa. Matenda, omwe amakhudzidwa pakukonzekera kwa tizilombo, kuphatikizapo:

- ІІІеццц

- інфекцій njira ya udzu,

- Інфекцій secchostatevo machitidwe,

- інфекцій шкіри і м'яких zovala.

Kuphatikiza ndi metronidazole kapena clarithromycin, pamakhala kugwiritsidwa ntchito kochizira zitsamba, komanso kuthana ndi udzu.

matenda mononucleosis, khansa ya m'mimba,

nthawi ya chaka

mwana wik 1 rock.

Mlingo wofananira wa ana ndi ana opitirira zaka 10 wofatsa kwa matenda operewera: 500 - 750 mg 2 kawiri pa dob; kwa ana a zaka 3 mpaka 10 - 375 mg kawiri kawiri pa dobo 250 mg katatu pa Dobu, vіkom vіd 1 thanthwe kuti 3 rokіv - 250 mg 2 kawiri pa doba kapena 125 mg katatu pa doba.

Ngati mukudwala matenda osachiritsika, mukayambiranso, mukudwala kwambiri, timakulitsa mankhwalawa; anagawira 0,75 - 1 g katatu pa dob, ana - 60 mg / kg kulemera kwa thupi, komanso katatu mpaka katatu.

Mlingo wapamwamba wa dobova wa doroslikh ndi 6 g.

Kwa Helicobacter pylori yomwe ikutha ndi malo ochepa a m'mimba mwa duodenum AMOKSIL ®, ipatseni malo osungiramo zinthu zochiritsira othandizira olimba padziko lonse lapansi:

- masiku 7: amoxicillin 1 ga 2 nthawi Doba + clarithromycin 500 mg 2 nthawi Doba + Omeprazole 40 mg 1 Abi 2 Priyomi,

- Masiku 7 kutalika: amoxicillin 0,75-11 g 2 kawiri pa dob + metronidazole 400 mg katatu pa dob + omeprazole 40 mg pa 1 kapena 2 priyomi.

Mlingo wapamwamba wa dobova wa doroslikh ndi 6 g.

Riven klubochkovo і fіltratsії, ml / hv

Korektsiya dozi safunikira

Mlingo wapamwamba ndi 500 mg 2 kawiri pa dob

Korektsiya dozi safunikira

15 mg / kg masi tila kawiri pa dob. Mlingo wapamwamba ndi 500 mg 2 kawiri pa dob.

Mlingo ndi makonzedwe

Mlingo wambiri mukamagwiritsa ntchito Amoxil® kwakukulu kwambiri. Dokotala ndi amene amawerengera mlingo, pafupipafupi pakukhazikitsa komanso nthawi yayitali ya chithandizo payekhapayekha.

Akuluakulu ndi anawokhala ndi thupi loposa 40 kg kutenga kuchokera ku 250 mg mpaka 500 mg wa amoxil® Katatu patsiku kapena kuchokera 500 mg mpaka 1000 mg kawiri pa tsiku. Kwa sinusitis, chibayo, ndi matenda ena akuluakulu, muyenera kumwa kuchokera 500 mg mpaka 1000 mg katatu patsiku. Mlingo wa tsiku ndi tsiku utha kuwonjezereka mpaka 6 g.

Ana masekeli zosakwana 40 kg nthawi zambiri amatenga 40-90 mg / kg / tsiku la Amoxil® tsiku lililonse mu magawo atatu mgulu kapena 25 mg mpaka 45 mg / kg / tsiku kawiri pazigawo ziwiri. Mlingo wapamwamba wa tsiku lililonse wa ana ndi 100 mg / kg thupi (osapitirira 3 g patsiku).

Ngati muli ndi matenda ofatsa pang'ono, tengani mankhwalawa mkati mwa masiku 5-7. Komabe, pamatenda oyambitsidwa ndi streptococci, kutalika kwa mankhwalawa kuyenera kukhala osachepera masiku 10.

Mankhwalawa matenda opatsirana, zotupa zakumalo, matenda omwe ali ndi vuto lalikulu, Mlingo wa mankhwala uyenera kutsimikiziridwa poganizira chithunzi cha matenda.

Mankhwalawa amayenera kupitilizidwa kwa maola 48 atatha zizindikiro za matendawa.

Amoxil® Itha kugwiritsidwa ntchito mwa odwala omwe ali ndi vuto la aimpso. A kwambiri aimpso kulephera (creatinine chilolezo