Insulin glulisine (Insulin glulisine): dzina lamalonda, mawonekedwe, malangizo ogwiritsira ntchito

Insulin imalembedwa kwa odwala matenda ashuga kuti azilamula shuga. Pakati pa mitundu yonse yomwe ilipo, insulini yocheperako nthawi zambiri imayikidwa, nthawi zambiri - yochepa kwambiri. Mankhwalawa amasiyanasiyana munthawi yomwe amapangidwira komanso zinthu zomwe adapangidwa. Njira zonse ziwiri zamankhwala zimagwiritsidwa ntchito limodzi pophatikiza mankhwala.

ZOFUNIKA KUDZIWA! Ngakhale odwala matenda ashuga kwambiri amatha kuchiritsidwa kunyumba, popanda opaleshoni kapena zipatala. Ingowerenga zomwe Marina Vladimirovna akunena. werengani zonena zake.

Insulin imagwiritsidwa ntchito ndi akatswiri othamanga ngati njira yowongolera kukula kwa minofu.

Shuga amachepetsedwa nthawi yomweyo! Matenda a shuga m'kupita kwa nthawi angayambitse matenda ambiri, monga mavuto amawonedwe, khungu ndi tsitsi, zilonda zam'mimba, zilonda zam'mimba komanso matenda otupa! Anthu amaphunzitsa zinzake zowawa kuti azisintha shuga. werengani.

Mlingo ndi makonzedwe

Njira imeneyi imagwiritsidwa ntchito pang'onopang'ono mphindi 15 musanadye. Mlingo umasankhidwa payekha.

Ndizotheka kugwiritsa ntchito makina ogwiritsa ntchito pampu. Chofunikira cha tsiku ndi tsiku cha insulin nthawi zambiri chimakhala cha 0,5. pa kilogalamu imodzi iliyonse: magawo awiri mwa magawo atatu aliwonse amakhala ndi insulin asanadye chakudya. Ndipo gawo limodzi mwa magawo atatu ali kuseri kwa insulin (basal).

Mankhwala "Apidra" ("Epidera"): malongosoledwe

Tiyeni tiganizire za mankhwalawa mwatsatanetsatane.

Apidra insulin imagwiritsidwa ntchito pochiza matenda a shuga kwa ana kuyambira wazaka zisanu ndi chimodzi, ndipo imagwiritsidwanso ntchito kwa achikulire. Kukonzekera kumakhala ndi ma milligram 3,49 a chinthu chachikulu. Izi zitha kufananizidwa ndi 100 IU (International Units) ya mahomoni amunthu. Zothandizira zina zimaphatikizapo jakisoni wamadzi limodzi ndi m-cresol, chloride ndi sodium hydroxide, hydrochloric acid, trometamol ndi polysorbate.

Apidra insulin imagulitsidwa mu botolo la mamililita 10 kapena makilogalamu atatu a millilita. Njira yoyamba imakhala ndi katoni, ndipo yachiwiri imayikidwa mu CD. M'mawu omaliza, pali makatakitala asanu omwe amalembetsa cholembera chapadera (ndiye kuti syringe), yomwe imatchedwa "OptiPen" (iyi ndi cholembera chotayika).

Wopangayo amapanganso njira yosiyanitsira cartridge ya OptiKlik. Mwamtheradi muzopopera zonse mumakhala madzi amadzimadzi osakhala ndi mtundu.

Apidra SoloStar

Gawo lomwe limagwira ntchito mmenemo limapezekanso ndendende monga momwe munasankhira kale. "Insulin glulisin" wokhala ndi dzina la malonda "Apollo brand SoloStar" ali ndi zotsutsana zotsatirazi:

• Kukhalapo kwa odwala a hypoglycemia ndi hypersensitivity a thupi kumunsi kapena wothandizanso pazinthu izi.
• Nthawi yaubwana imafika zaka zisanu ndi chimodzi.

Mankhwala a Apidra ndi Apidra Solostar angagulidwe pa intaneti iliyonse ya pharmacy.

Zobisika za kugwiritsa ntchito mankhwalawa

"Insulin glulisin" imakhala yofanana ndi anthu. Kupatula kokha ndi nthawi yowonekera, yomwe ndiyofupikitsa. Ndikokwanira kupatsa wodwalayo jakisoni imodzi yokha ya mankhwalawa, chifukwa pakatha mphindi 15 amva bwino mu mkhalidwe wake.

Njira zolowetsera zimatha kusiyanasiyana. Mwachitsanzo, wothandizirayu amadzipaka pang'onopang'ono m'malo ena kenako, ndi kugwiritsa ntchito pampu ya insulin, njirayi imatha. Kulowetsedwa kumatha kuchitidwa popanda kusokoneza, komwe kumachitika m'mafuta am'madzi mwachindunji pansi pa khungu.

Ndondomeko iyenera kuchitidwa musanadye kapena pambuyo chakudya, koma osati yomweyo. Jakisoni wotsekemera amachitika bwino m'mimba, komanso amaloledwa paphewa, ndipo ntchafu yake ndiyabwino. Koma kulowetsedwa kutha kuchitidwa kokha m'mimba. Ndi madokotala okha omwe angatchule dongosolo la mankhwala. Mankhwalawa amagwiritsidwa ntchito kupatsa insulin nthawi yayitali kapena yapakatikati.

Amaloledwa kuphatikiza kulowetsa kwa "Insulin glulisin" ndi mapiritsi (kugwiritsa ntchito mankhwala a hypoglycemic). Mlingo ndi kusankha kwa mankhwalawo kumatsimikiziridwa ndi adotolo, popeza wodwalayo alibe ufulu wosankha yekha. Chowonadi ndi chakuti izi ndizodzaza ndi zotsatira zoyipa kwambiri. Mwa malangizo ofunikira oti mugwiritse ntchito, mutha kupezanso malangizo oyang'anira madera oyendetsa mankhwalawo. Ndikofunikira kuti muchepetse kuwonongeka kwa mitsempha yamagazi.

Ndi malangizo enanso ati omwe angagwiritsidwe ntchito ndi Insulin Glulizin?

Malangizo apadera ogwiritsira ntchito mankhwala

Mothandizidwa ndi mtsempha wa magazi amachitika m'madipatimenti apadera a endocrinological. Mukamagwiritsa ntchito insulini aspart mumapampu a subcutaneous makonzedwe, kusakaniza mankhwalawa ndi zothetsera zina ndizoletsedwa.

Ma cholembera omwe amagwiritsidwa ntchito amayenera kusungidwa pokhapokha kutentha. Cholembera chosagwiritsidwa ntchito chiyenera kusungidwa mufiriji. Mankhwalawa amayenera kuperekedwa pokhapokha atasakaniza bwino zomwe zili mu syringe mpaka utayera, utoto wofanana.

Kuchita zolimbitsa thupi kwambiri, komanso kufananizira matenda opatsirana ndi kutupa, kudzafunika insulini yowonjezera.

Kumayambiriro kwa zamankhwala, kuyendetsa galimoto sikulimbikitsidwa, komanso, gwiritsani ntchito zoyenda chifukwa cha kuwonongeka kwa mawonekedwe. Potengera maziko a kuphatikiza mankhwala, kusamala kuyenera kuchitika pokhudzana ndi kuchitika kwa hypoglycemia.

Zotsatira zoyipa za ntchito

Mitsempha yamkati yamanjenje, monga zotumphukira, imatha kuyankha ku Insulin Glulisine pokhazikitsa mwachangu kuchuluka kwa shuga kumayambiriro kwa chithandizo. Kuyamba kwa ululu wammbuyo wam'mimba ndikotheka, komwe kumatha kusiyana mosakhalitsa. Pakati pazakhudzana ndi dermatological, ndikofunikira kutchula lipodystrophy pamalo operekera mankhwalawa mankhwalawa.

Ziwalo zam'maganizo zimatha kuyankha molakwika, komanso, kuchepa kwa mawonekedwe owonekera, omwe adzaphatikizidwenso ndi kuthamanga kwa kukhalapo kwa shuga m'magazi kumayambiriro kwa chithandizo. Izi zitha kukhala zosakhalitsa. Monga gawo logwiritsira ntchito chida ichi, zinthu zosiyanasiyana zomwe zimachitika sizimasiyana.

Insulin Apidra Solostar: malangizo ogwiritsira ntchito yankho

Apidra Solostar ndi insulin yochepa, yomwe cholinga chake ndi kuwongolera glycemic m'njira yodalira matenda a shuga.

Amalembera achikulire ndi ana azaka zopitilira 6 omwe akudwala matenda ashuga, ngati kuli kotheka, mankhwala a insulin.

Mu 1 millilita ya Apidra Solostar yankho lili ndi chokhacho chophatikizira - insulin glulisin mu gawo la 100 PIECES. Komanso, mankhwalawa ali ndi:

• Hydroskide ndi Sodium Chloride
• Madzi okonzedwa
• Metacresol
• Polysobat
• Trometamol
• Hydrochloric acid.

Njira yokhala ndi insulini ndi madzi osavuta, osasankhidwa, omwe amapezeka mumbale 3 ml. Paketiyi imaphatikizapo mabotolo amodzi kapena asanu okhala ndi zolembera.

Insulin glulisin yomwe ili mu Apidra ndi njira yofananira ndi ya insulin yomwe imapangidwa m'thupi la munthu. Glulisin amachita zinthu mwachangu kwambiri ndipo amadziwika ndi nthawi yochepa poyerekeza ndi insulin yachilengedwe.

Mothandizidwa ndi insulin glulisin, kusintha pang'onopang'ono kwa kagayidwe ka glucose kumawonedwa. Ndi kuchepa kwa shuga, kukondoweza kwa mayamwidwe ake mwachindunji ndi zotumphukira, kuphatikizira kwa kaphatikizidwe ka glucose m'maselo a chiwindi amalembedwa.

Insulin imalepheretsa njira ya lipolysis yomwe imachitika mu adipocytes, komanso proteinolysis. Nthawi yomweyo, kaphatikizidwe wamaproteni amakula kwambiri.

Chifukwa cha kafukufuku wambiri ndi kutenga nawo mbali anthu omwe ali ndi matenda ashuga, komanso odwala athanzi, zotsatira zotsatirazi zidapezeka: ndi subcutaneous makonzedwe a Apidra, kuchitapo kanthu mofulumira kwa insulin kumawonedwa ndi kufupika kwakanthawi kuposa insulin yamadzimadzi yotentha.

Pambuyo pa kukhazikitsidwa kwa glulisin pansi pa khungu, zotsatira zake zimadziwika pambuyo pa mphindi 10-20. Koma pakubayidwa m'mitsempha, ndolo ya glucose imatsika chimodzimodzi ngati pambuyo pobweretsa insulin yachilengedwe. 1 unit ya insulin glulisin imadziwika ndi katundu wofanana ndi glucose wofanana ndi gawo limodzi la insulin yachilengedwe.

Odwala omwe ali ndi matenda a aimpso, kufunika kwa insulin nthawi zambiri kumachepetsedwa.

Subcutaneous makonzedwe a Apidra ayenera kuchitika musanadye kapena pambuyo chakudya.

Mankhwala okhala ndi insulin ayenera kugwiritsidwa ntchito molingana ndi dongosolo la mankhwala antidiabetesic limodzi ndi insulin, yomwe imadziwika ndi kutalika kwakanthawi kapena insulin. Mwina mungagwiritse ntchito mankhwala ophatikizira a hypoglycemic pakamwa.

Kusankhidwa kwa regimen ya muyezo kumachitika ndi endocrinologist.

Mafala Akutoma

Kukhazikitsidwa kwa yankho la insulini kumachitika mosadukiza ndi jakisoni kapena kulowetsedwa pogwiritsa ntchito pulogalamu yapadera ya pampu.

Subcutaneous jakisoni imachitika m'mimba khoma (mwachindunji mbali yake yakumbuyo), m'chigawo chachikazi kapena phewa. Kulowetsedwa kwa mankhwala ikuchitika m'mimba khoma. Malo omwe kulowetsedwa ndi jekeseni ayenera kukhala akusintha mosalekeza.

Momwe mungagwiritsire ntchito cholembera

Apidra isanayambike, cholembera chimakhala chofunikira kuti chiwotche kutentha pang'ono (pafupifupi maola 1-2).

Singano yatsopano imalumikizana ndi cholembera cha insulin, ndiye kuti muyenera kuyesa mayeso otetezeka. Pambuyo pake, chizindikirocho "0" chidzawoneka pazenera la drr. Kenako mulingo woyenera umakhazikitsidwa. Mtengo wocheperako wa mlingo womwe waperekedwa ndi gawo limodzi, ndipo pazofunikira ndi magawo 80. Ngati pakufunika bongo wambiri, jakisoni zingapo zimaperekedwa.

Nthawi ya jakisoni, singano, yomwe imayikidwapo cholembera, imayenera kuyikiridwa pang'onopang'ono pakhungu. Batani pa syringe cholembera lidzakanikizidwa, liyenera kukhalabe pomwepo mpaka mphindi yakucha. Izi zimathandizira kuyambitsidwa kwa mlingo woyenera wa mankhwala okhala ndi insulin.

Pambuyo jakisoni, singano imachotsedwa ndikuitaya. Chifukwa chake, zitha kuteteza matenda a insulin. M'tsogolomo, cholembera cha syringe iyenera kutsekedwa ndi chipewa.

Mankhwala atha kuperekedwa kwa amayi apakati komanso akakhanda.

Mtengo: kuchokera 421 mpaka 2532 rub.

Mankhwala okhala ndi insulin Apidra Solostar sagwiritsidwa ntchito kuwonetsa hypoglycemia ndikuwonjezereka kwa magawo a mankhwala.

Mukamagwiritsa ntchito mankhwala ena a insulin ochokera kwa wopanga wina, muyenera kuwongolera chithandizo chamankhwala a antiidiabetic ndi dokotala, chifukwa kufunika kosintha kwakumwa kwa mankhwalawo sikungadziwike. Mungafunike kusintha chiwembu cha hypoglycemic mankhwalawa pakamwa.

Kutsiliza kwa mankhwala othandizira kapena kugwiritsa ntchito mankhwala osokoneza bongo okwanira, makamaka mwa anthu omwe ali ndi matenda ashuga, kumatha kuyambitsa matenda a shuga komanso matenda a hypoglycemia.

Nthawi yopezeka ya hypoglycemia ikukhudzana mwachindunji ndi kuchuluka kwa chitukuko cha hypoglycemic kuchokera ku mankhwala omwe amagwiritsidwa ntchito, amatha kusintha ndi kusintha kwa chithandizo cha antidiabetesic.

Zina zomwe zimatha kuchepetsa zovuta za hypoglycemia, zimaphatikizapo:

• Matenda a shuga osakhalitsa
• Kwambiri insulin mankhwala
• Kukula kwa matenda a shuga
• Kugwiritsa ntchito mankhwala angapo (mwachitsanzo, β-blockers).

Kusintha kwa mlingo wa insulin Apidra Solostar kumachitika ndikuwonjezera kwa zolimbitsa thupi kapena kusintha kwa zakudya za tsiku ndi tsiku.

Pankhani ya kuchuluka zolimbitsa thupi mutatha kudya, mwayi wokhala ndi hypoglycemia ukuwonjezeka. Kuchita insulin mwachangu kungayambitse hypoglycemia.

Zizindikiro zosasinthika za hypo- ndi hypoglycemic zimayambitsa kupezeka kwa matenda a shuga, chikomokere, kapena kutsogolo kwa imfa.

Ndi kusintha kwa mkhalidwe wamalingaliro, kukula kwa matenda ena, pangafunikire kusintha mlingo wa mankhwala okhala ndi insulin.

Mukamagwira ntchito mosamala, magalimoto oyendetsa, chiopsezo chokhala ndi hypo- ndi hyperglycemia chikuwonjezeka, choncho muyenera kusamalidwa mwapadera.

Mukamamwa mankhwala ena, zimachitika kuti kagayidwe kazakudwala kajambulidwe, mogwirizana ndi izi, pakufunika kusintha Mlingo wa glulisin ndikuwongolera machitidwe a antidiabetesic mankhwala.

Mwa zina mwa mankhwala omwe amalimbikitsa kuchuluka kwa hypoglycemic a glulisin ndi:

• Zoletsa zina za angiotensin zotembenuza enzyme, monoamine oxidase
• Pentoxifylline
• Mankhwala othandizira
• Njira zochokera sulfonamide antimicrobial agents
• Ma discopyramid
• Hypoglycemic mankhwala opangira pakamwa
• Fluoxetine
• Salicylates
• Propoxyphene.

Mankhwala angapo amaperekedwa omwe amachepetsa kwambiri hypoglycemic zotsatira za yankho la insulin:

• Isoniazid
• Somatropin
• Danazole
• Ena achifundo
• Mankhwala a estrogen-progestin
• COC
• Diazoxide
• Mapuloteni oletsa
• Mahomoni a chithokomiro
• Mankhwala a antipsychotic
• GKS
• Phenothiazine Derivatives
• Mankhwala osokoneza bongo.

Ndizofunikira kudziwa kuti β-adrenergic blocking agents, mankhwala okhala ndi ethanol ndi ma lithiamu, clonidine amatha kuwonjezera ndikuchepetsa mphamvu ya hypoglycemic ya Apidra.

Pogwiritsa ntchito reserpine, β-adrenoblockers, clonidine, ndi guanethidine, zizindikiro za hypoglycemia zitha kukhala zopanda mphamvu kapena zosakhalapo.

Popeza palibe chidziwitso pakudziwika kwa mankhwala a gluzilin, osasakanikirana ndi mankhwala ena, insulin isofan ndiyosiyana.

Pankhani yogwiritsa ntchito pampu kulowetsedwa kupatsa Apidra, kusakaniza njira yokhala ndi insulin ndi mankhwala ena sikuyenera kutero.

Nthawi zambiri, anthu odwala matenda ashuga amatha kukhala ndi vuto ngati hypoglycemia.

Nthawi zina, totupa pakhungu ndi maonekedwe a kutupa kwanuko kumawonedwa.

Kupezeka kwa lipodystrophy ngati sikutsatira dongosolo lodziwika bwino la chithandizo chamankhwala sikulakwa.

Mawonetseredwe ena amisala:

• Matenda a khungu lawo siligwirizana, mwachangu ndi mtundu wa uritisaria, kupindika
• Kumverera kwamphamvu m'chifuwa (m'malo osowa).

Ndikofunika kudziwa kuti zomwe zimachitika pakhungu lathupi lathu (chiwonetsero cha thupi lawo) zimathandizidwenso tsiku lotsatira jekeseni. Nthawi zina, zizindikiro zoyipa sizobwera chifukwa cha kuwonekera kwa insulin, koma chifukwa cha mkwiyo pakhungu chifukwa cha chithandizo chamankhwala chisanachitike.

Mukazindikira matenda amtundu wonse, chiopsezo cha kufa chimakhala chachikulu. Chifukwa chake, pakuwonetsedwa pang'ono kwa zovuta zammbali, muyenera kufunsa dokotala.

Ndi kukhazikitsidwa kwa mankhwala ochulukirapo a Apidra, hypoglycemia ikhoza kukhala yofatsa komanso yowopsa. Pankhaniyi, ndikofunikira kuchitira chithandizo:

• Ofatsa - Zakudya zokhala ndi shuga kapena zakumwa
• Mawonekedwe owopsa (osazindikira chikumbumtima) - pakuyimitsidwa, 1 ml ya mankhwala Glucagon amaperekedwa pansi pa khungu kapena minofu, osagwirizana ndi Glucagon, njira yolowerera shuga ndiyotheka.

Wodwala akayambanso kuzindikiridwa, zidzakhala zofunikira kumamupatsa chakudya chamafuta ambiri. Pambuyo pake, kuwunika momwe wodwalayo alili ndi dokotala wololedwa kumalimbikitsidwa.

Ely Lilly ndi Company, France

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Humalogue ndi amodzi mwa othandizira omwe amawonetsa zotsatira za hypoglycemic. Humalog ili ndi insulin lyspro. Mothandizidwa ndi mankhwalawa, ndizotheka kuyendetsa kagayidwe kazakudya ndikuwonjezera kwambiri mapuloteni. Mankhwala amapangidwa mwanjira yankho ndi kuyimitsidwa.

Ubwino:

• Kugwiritsa ntchito
• Kukhazikika kwa hypoglycemic kwambiri
• Kuthekera kopanga zovuta zoyipa ndikotsika.

Chuma:

• Musagwiritse ntchito ngati hypoglycemia ikukayikiridwa.
• Mtengo wokwera
• Zitha kuputa thukuta kwambiri.

Eli Lilly East S.A., Switzerland

Mtengo kuyambira 148 mpaka 1305 rub.

Humulin NPH - mankhwala omwe ali ndi yogwira insulin-isophan, amagwiritsidwa ntchito mu shuga kuwongoletsa glycemia. Humulin NPH imapangidwa mwa njira yothetsera mavitamini omwe amagwiritsidwa ntchito cholembera.

Ubwino:

• Atha kulembetsa kukhala ndi pakati
• Gwiritsani ntchito matenda oyamba a shuga
• Mankhwala aantidiabetic a nthawi yayitali amaloledwa.

Chuma:

• Zingayambitse kuyabwa kwadzaoneni.
• Pazotsatira zamankhwala, kugunda kwa mtima kumatha kupezeka
• Amangotulutsidwa ndi mankhwala okha.

Novo Nordic, Denmark

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LS ili ndi insulin yochepa. Amalandira mankhwala a shuga osagwirizana ndi glycemic control ndi mankhwala ena. Mothandizidwa ndi Actrapid, njira yodziyimira mkati mwake imayambitsidwa chifukwa cha kukondoweza kwa cAMP biosynthesis komanso kulowa mwachangu m'maselo a minofu. The yogwira thunthu ndi sungunuka insulin. Mankhwala amapangidwa mwanjira yothetsera.

Ubwino:

• Mtengo wotsika
• Kuchepetsa msanga kwa shuga m'magazi
• Itha kugwiritsidwa ntchito ndi insulin yayitali.

Chuma:

• Maonekedwe a zizindikiro za lipodystrophy samatsutsidwa
• Quincke edema imayamba
• Ndi zochulukirapo zolimbitsa thupi, kusintha kwa mlingo kumafunika.

Ultrashort insulin Glulizin - mawonekedwe ndi mawonekedwe a ntchito

Mtundu wa matenda ashupi amtundu woyamba, wodwala amatha kugwiritsa ntchito insulin yofulumira (yofulumira), yochepa, yapakati, yayitali komanso yosakaniza.

Yemwe angafotokozere za mtundu wokwanira wa mankhwala zimadalira munthu payekha. Pakakhala insulin yayifupi kwambiri, Glulisin amagwiritsidwa ntchito.

Insulin Glulisine ndi analogue ya insulin ya anthu, yomwe imafanana ndi mahomoni awa. Koma mwachilengedwe, imagwira ntchito mwachangu komanso imakhala yochepa.

Glulisin imaperekedwa ngati yankho la subcutaneous makonzedwe. Chimawoneka ngati madzi owonekera popanda zosayera.

Mayina amalonda a mankhwala okhala ndi iye: Apidra, Epidera, Apidra Solostar. Cholinga chachikulu cha mankhwalawa ndikukhazikitsa kagayidwe ka glucose.

Malinga ndi zomwe zikuchitika, zabwino ndi zovuta izi:

• Amachita mofulumira kuposa mahomoni amunthu (+),
• imakwaniritsa kufunika kwa chakudya mu insulin (+),
• kuthekera kosagwirizana ndi mphamvu ya mankhwalawa m'magazi a shuga (-),
• mphamvu yayikulu - gawo limachepetsa shuga kuposa ma insulin ena (+).

Pambuyo pa subcutaneous makonzedwe, pali kuchepa kwa shuga chifukwa cha kukoka kwake kwa kugwiritsidwa ntchito kwake mu minofu komanso kupsinjika kwa njirazi mu chiwindi. Kuchitikaku kumayambira mphindi 10 jekeseni.

Ndi kukhazikitsidwa kwa Glulisin ndi insulini yokhazikika mphindi zochepa asanadye, wakale amakhala ndi mphamvu yolamulira pakatha kudya. The bioavailability wa chinthu pafupifupi 70%.

Kulumikizana ndi mapuloteni a plasma ndikosatheka. Amachotseredwa mwachangu kuposa momwe amachitira majekiseni amtundu wa anthu. Hafu ya moyo wa mphindi 13.5.

Mankhwalawa amaperekedwa nthawi yomweyo musanadye (kwa mphindi 10-15) kapena mukangomaliza kudya, poganizira mankhwala omwe mumalandira ndi ma insulin ena (munthawi ya chochita kapena kuyambira). Njira zoyendetsera: mwapang'onopang'ono ntchafu, phewa. Popewa kuvulala, tsamba la jakisoni limatsitsidwa. Mankhwalawa amaperekedwa m'malo osiyanasiyana, koma m'malo omwewo.

Glulisin amaphatikizidwa ndi ma insulin ndi othandizira otsatirawa:

• ndi analog ya basal hormone,
• ndi pafupifupi
• ndi lalitali
• Mankhwala okhala ndi hypoglycemic.

Mphamvu ya glycemia ndi kuwonjezera kwa insulin Glulizin kuchiritsa ndi basal insulin

Ngati njira yothetsera vutoli ikuyenera kuperekedwa pogwiritsa ntchito zolembera, ma jakisoni amachitidwa mogwirizana ndi malangizo a limangiroli. Mlingo wa mankhwalawa umasankhidwa payekha, poganizira momwe wodwalayo alili komanso kuchuluka kwa chiphuphu.

Musanagwiritse ntchito Glulizin, yodzazidwa mu cartridge, kuyendera kumachitika - njira yamatope yokhala ndi inclusions sioyenera kugwiritsidwa ntchito.

Malangizo a kanema ogwiritsa ntchito cholembera:

Mankhwala amalembedwa motere:

Contraindging poika mankhwala ali motere:

• achina,
• Hypersensitivity to glulisin,
• Hypersensitivity pamavuto othandizira a mankhwalawo.

Munthawi ya mankhwala ndi mankhwala, zimachitika zovuta.

Pafupipafupi zochitika zolakwika pamanambala, pomwe 4 ndizofala kwambiri, 3 nthawi zambiri, 2 ndizosowa, 1 ndiyosowa kwambiri:

Pa bongo wambiri, hypoglycemia ya zovuta zosiyanasiyana imawonedwa. Itha kuchitika nthawi yomweyo kapena kukula pang'onopang'ono.

Kutengera mphamvu ya insulin mankhwala, nthawi yayitali komanso kuuma kwa matendawa, zizindikiro za hypoglycemia zitha kusokonekera kwambiri. Wodwala ayenera kulingalira izi kuti ateteze vutolo munthawi yake. Kuti muchite izi, muyenera kukhala ndi shuga (maswiti, chokoleti, ma cubes opanda shuga) nanu.

Ndi hypoglycemia yolimbitsa komanso yolimbitsa, zinthu zomwe zimakhala ndi shuga zimatengedwa. Woopsa, komanso limodzi ndi kuwonongeka kwa chikumbumtima, jakisoni adzafunika.

Mpumulo wa hypoglycemia umachitika mothandizidwa ndi glucagon (s / c kapena i / m), yankho la glucose (i / v). Pakupita masiku atatu, mkhalidwe wa wodwalayo umayang'aniridwa. Popewa kukula kwa hypoglycemia wobwerezabwereza, ndikofunikira kumwa chakudya pakapita kanthawi.

Kumayambiriro kwa mankhwala omwe ali ndi insulin ya ultrashort, kuyanjana kwake ndi mankhwala ena kumazingidwa.

Mankhwala ambiri amatha kuthana ndi kagayidwe ka glucose, kukulitsa kapena kuchepetsa zotsatira za insulin. Asanalandire chithandizo, wodwala ayenera kudziwitsidwa kuti apewe mavuto.

Mankhwala otsatirawa amalimbikitsa zotsatira za Glulisin: Fluoxetine, othandizira a hypoglycemic mapiritsi, makamaka, sulfonylureas, sulfonamides, salicylates, fibrate, ACE inhibitors, Disopyramide, MAO inhibitors, Pentoxifylline, Propoxifen.

Mankhwala otsatirawa amachepetsa mphamvu ya mankhwala a insulin: atypical antipsychotic, sympathomimetics, kulera kwapakamwa, mahomoni a chithokomiro, glucagon, mahomoni achigololo achikazi, thiodiphenylamine, somatropin, diuretics, glucocorticosteroid mankhwala (GCS), proteinase inhibitors,

Pentamidine, beta-blockers, ndi clonidine amatchulidwa kwa mankhwala omwe mosasamala angakhudze mphamvu ya chiwonetsero cha Glulisin komanso kuchuluka kwa shuga (kuchepa ndi kuwonjezeka). Mowa ulinso ndi zomwezo.

Kusamala kwakukulu kumawonedwa popereka pioglitazone kwa odwala omwe ali ndi mtima matenda a mtima. Akaphatikizidwa, milandu ya kukhazikika kwa mtima idanenedwa mwa odwala omwe ali ndi chiyembekezo cha matendawa.

Ngati chithandizo cha pioglitazone sichitha kutha, ndikofunikira kuyang'anira momwe zinthu ziliri. Ngati zizindikiro zilizonse zamtima (kuwonda, kutupa) ziwoneka, kugwiritsa ntchito mankhwalawa kumachotsedwa.

Wodwalayo ayenera kuganizira izi:

1. Ndi vuto la impso kapena kuphwanya ntchito yawo, kufunika kwa insulini kungachepe.
2. Ndi kukanika kwa chiwindi, kufunikira kumacheperanso.
3. Chifukwa cha kusowa kwa chidziwitso, mankhwalawa saikidwa kwa ana osakwana zaka 6.
4. Gwiritsani ntchito mosamala amayi apakati omwe ali ndi kuyang'anira pafupipafupi pazisonyezo.
5. Pa mkaka wa m`mawere, kusintha kwa mlingo ndi zakudya zimafunika.
6. Mukasintha kupita ku Glulisin kuchokera ku mahomoni ena chifukwa cha hypersensitivity, kuyesedwa kwa ziwengo kuyenera kuchitidwa kupatula kusagwirizana.

Kusintha kwa Mlingo kumachitika pa kusintha kwa mtundu wina wa mahomoni obayira. Mukasamutsa kuchokera ku insulin ya nyama kupita ku Glulisin, mlingo umakonda kusintha m'njira yochepetsera chomaliza. Kufunika kwa mankhwalawa kumasintha ndikusokonezeka kwam'maganizo / m'maganizo, munthawi ya matenda opatsirana.

Chiwembucho chimayendetsedwa mothandizidwa ndi mankhwala a mapiritsi a hypoglycemic. Ngati mutasintha gawo lililonse la pulogalamuyi, mungafunike kusintha mlingo wa Glulisin.

Nthawi zambiri za hyperglycemia / hypoglycemia, zotsatirazi zomwe zimadalira mlingo zimafotokozedwa kaye musanayambe kuchuluka kwa mankhwalawa:

• njira ndi malo operekera mankhwala,
• Kutsatira njira zamankhwala,
• kumwa mankhwala ena limodzi
• psycho-state state.

Alumali moyo mutatsegula - mwezi

Kusungirako - kuyambira pa +2 mpaka + 8ºC. Osati kuzizira!

Kupumula ndikumvera mankhwala.

Glulisin ndiwofanana ndi insulin ya anthu:

Glulisin ndi mahashoni a ultrashort wokhazikitsa kagayidwe ka glucose. Amayikidwa limodzi ndi ma insulin ena, poganizira masankho omwe adasankhidwa. Musanagwiritse ntchito, ndikofunikira kuphunzira malangizo ndi kulumikizana ndi mankhwala ena.

Mankhwala insulin glulisin: malangizo ntchito

Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin. Zimayambitsidwa m'thupi kokha mothandizidwa ndi jakisoni. Imayendetsa moyenera Zizindikiro za glycemic.

Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin.

Kusunga kwa ATX - A10AV06.

Ipezeka pansi pa mayina amalonda Apidra ndi Apidra SoloStar.

Mankhwalawa ndi njira yofananiranso yamankhwala a insulin. Mphamvu yakuchitapo kanthu ndi yofanana ndi imelo yomwe imapangidwa ndi kapamba wabwino. Glulisin amachita zinthu mwachangu komanso amakhala ndi mphamvu yayitali.

Pambuyo makonzedwe kwa thupi (subcutaneously), timadzi timayamba kukhazikitsa kagayidwe kazachilengedwe.

Thupi limachepetsa kuchuluka kwa shuga m'magazi, limalimbikitsa mayamwidwe ake ndi minyewa, makamaka minofu yamatumbo ndi minofu ya adipose. Amalepheretsa mapangidwe a glucose mu zimakhala za chiwindi. Kuchulukitsa mapuloteni.

Kafukufuku wachipatala akuwonetsa kuti glulisin, womwe umaperekedwa kwa mphindi ziwiri asanadye, umaperekanso kuchuluka kwa shuga m'magazi momwe munthu amasungunulira insulin, yoyendetsedwa ndi theka la ola asanadye.

Zochita za insulin sizisintha mwa anthu amitundu yosiyanasiyana.

Pambuyo subcutaneous makonzedwe a mankhwala, pazenera ambiri mu magazi amafika pambuyo mphindi 55. Nthawi yayitali yakukhala mankhwala omwe ali m'magazi ndi mphindi 161. Ndi subcutaneous makonzedwe a mankhwalawa m'dera lakhomopo khoma kapena phewa, mayamwidwe mwachangu kuposa kukhazikitsa kwa mankhwala mu ntchafu. Bioavailability pafupifupi 70%. Kuchotsa theka-moyo pafupifupi mphindi 18.

Pambuyo pakuyendetsa pang'onopang'ono, glulisin imachotsedwako mwachangu kuposa insulin yamunthu yomweyo. Ndi kuwonongeka kwa impso, kuthamanga kwa kuyambira kwa zomwe zimafunikira kumakhazikika. Zambiri pazakusintha kwamatenda a insulin mwa okalamba sizinaphunzitsidwe mokwanira.

Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.

Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.

Mankhwala ndi contraindicated vuto la hypoglycemia ndi hypersensitivity kwa Apidra.

Imaperekedwa pang'onopang'ono 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni. Simungathe kusakaniza mitundu ingapo ya insulini mu syringe yomweyo, ngakhale kuti wodwalayo akhoza kupatsidwa ma insulin osiyanasiyana. Kubwezeretsanso yankho lisanayambike makonzedwe ake.

Musanagwiritse ntchito, muyenera kuyang'ana botolo. Ndikothekanso kusungitsa yankho mu syringe pokhapokha ngati yankho likuwonekera komanso lilibe tinthu tambiri.

Khola lomweli liyenera kugwiritsidwa ntchito ndi wodwala m'modzi. Ngati yawonongeka, saloledwa kuigwiritsa ntchito. Musanagwiritse ntchito cholembera, fufuzani mosamala cartridge. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka komanso lopanda zosayera. Cholembera chopanda kanthu ziyenera kutayidwa ngati zinyalala za pabanja.

Mankhwalawa kutumikiridwa subcutaneously 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni.

Pambuyo pochotsa kapu, tikulimbikitsidwa kuti mulembe mayendedwe ndi yankho. Kenako ikani singano mosamala ndi cholembera. Mu chipangizo chatsopano, chizindikiro cha mankhwalawa chimawonetsa "8". Ntchito zina, ziyenera kuyikidwa pambali pa chizindikiro "2". Kanikizani batani la dispenser njira yonse.

Kugwira chiwongoladzanja, chotsani thovu lamkati podina. Ngati zonse zachitika molondola, dontho laling'ono la insulini limawonekera pamphumi ya singano. Chipangizocho chimakuthandizani kuti muyike mlingo kuchokera pa 2 mpaka 40 mayunitsi. Izi zitha kuchitika ndikutembenuza chotumiza. Kulipiritsa, batani la dispenser likulimbikitsidwa kuti lizikokedwa njira yonse.

Ikani singano m'matumba a subcutaneous. Kenako dinani batani njira yonse. Asanachotsere singano, iyenera kuchitidwa kwa masekondi 10. Pambuyo pa jakisoni, chotsani ndikuchotsa singano. Mulingo wake ukuonetsa kuchuluka kwa insulini yomwe imatsala mu syringe.

Ngati cholembera sichingagwire ntchito molondola, ndiye kuti yankho limatha kutengedwa kuchokera ku cartridge kupita ku syringe.

Zotsatira zoyipa kwambiri za insulin ndi hypoglycemia. Itha kuchitika chifukwa chogwiritsa ntchito mlingo waukulu wa mankhwalawa. Zizindikiro zakuchepa kwa shuga m'magazi zimayamba pang'onopang'ono:

• thukuta lozizira
• khungu komanso kuzirala kwa khungu,
• kutopa kwambiri
• chisangalalo
• zosokoneza zowoneka
• kunjenjemera
• nkhawa zazikulu
• chisokonezo, zovuta kuyang'ana,
• kumva kupweteka m'mutu,
• palpitations.

Hypoglycemia ikhoza kuchuluka. Uku ndikuwopseza moyo, chifukwa kumayambitsa kusokonezeka kwa ubongo, ndipo m'malo ovuta kwambiri - imfa.

Pa malo a jakisoni, kuyabwa ndi kutupa kumachitika. Kuchita koteroko kwa thupi kumakhala kwakanthawi, ndipo simuyenera kumwa mankhwala kuti muchotse. Mwina chitukuko cha lipodystrophy mwa akazi pamalo opangira jakisoni. Izi zimachitika ngati zalembedwa pamalo amodzi. Kuti izi zisachitike, tsamba la jakisalo liyenera kusinthidwa.

Ndizachilendo kwambiri kuti mankhwala amatha kuyambitsa ziwopsezo.

Ndi hypoglycemia, ndizoletsedwa kuyendetsa galimoto kapena kugwiritsa ntchito njira zovuta.

Kusamutsa wodwala ku mtundu watsopano wa insulin kumachitika kokha moyang'aniridwa ndi achipatala. Nthawi zina, chithandizo cha hypoglycemic chingafunikire. Mukamasintha zolimbitsa thupi, muyenera kusintha mlingo wake.

Mankhwalawa amatha kugwiritsidwa ntchito mukalamba. Mankhwala osokoneza bongo safunikira.

Insulin yamtunduwu imatha kuperekedwa kwa ana azaka zopitilira zisanu ndi chimodzi.

Pali umboni wochepa wokhudza kugwiritsa ntchito mankhwalawa panthawi ya bere komanso poyamwitsa. Kafukufuku wazinyama wa mankhwalawa sanawonetse zotsatira zam'mimba.

Popereka mankhwala awa kwa amayi apakati, muyenera kusamala kwambiri. Ndikofunikira kuyeza shuga m'magazi.

Odwala omwe ali ndi vuto la matenda ashuga ayenera kuyang'anitsitsa kuchuluka kwa shuga m'magazi.Pa trimester yoyamba, zofunika za insulin zimatha kuchepera pang'ono. Kaya insulin idutsa mkaka wa m'mawere sichikudziwika.

Osasintha kuchuluka kwa mankhwalawa omwe amaperekedwa ndi mankhwalawo othandizira kuwonongeka kwa impso.

Maphunziro azachipatala kwa odwala omwe ali ndi vuto la chiwindi ntchito sanachitepo.

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo digiri yake imatha kukhala yosiyana - kuyambira yofatsa mpaka yamphamvu.

Magawo a hypoglycemia ofatsa amaletsedwa kugwiritsa ntchito shuga kapena shuga. Ndikulimbikitsidwa kuti odwala nthawi zonse azikhala ndi maswiti, makeke, msuzi wokoma, kapena zidutswa za shuga woyengedwa nawo limodzi.

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo digiri yake imatha kukhala yosiyana - kuyambira yofatsa mpaka yamphamvu.

Ndi kuchuluka kwambiri kwa hypoglycemia, munthu amasiya kuzindikira. Glucagon kapena dextrose amaperekedwa ngati thandizo loyamba. Ngati palibe chochitika pakayendetsedwe ka glucagon, ndiye kuti jakisoni yemweyo imabwerezedwa. Pambuyo podzikanso, muyenera kupatsa wodwalayo tiyi wokoma.

Mankhwala ena amatha kuthana ndi shuga kagayidwe. Izi zimafunikira kusintha kwa insulin. Mankhwala otsatirawa amalimbikitsa hypoglycemic zotsatira za Apidra:

• othandizira otsegula pakamwa,
• ACE zoletsa
• Ma Disopyramides,
• mafupa
• Fluoxetine,
• monoamine oxidase zoletsa zinthu
• Pentoxifylline
• Propoxyphene,
• salicylic acid ndi zotumphukira zake,
• sulfonamides.

Mankhwala oterewa amachepetsa ntchito ya insulin:

• GKS,
• Danazole
• Diazoxide
• okodzetsa
• Isoniazid,
• Phenothiazine zotumphukira
• Kukula kwamafuta,
• chithokomiro cha chithokomiro,
• mahomoni ogonana achikazi omwe amapezeka mu mankhwala oletsa kubereka,
• zinthu zomwe zimalepheretsa mapuloteni.

Beta-blockers, clonidine hydrochloride, kukonzekera kwa lifiyamu kungakulitse, kapena,, kufooketsa ntchito ya insulin. Kugwiritsidwa ntchito kwa pentamidine kumayambitsa hypoglycemia, kenako kuwonjezeka kwakuchuluka kwa glucose wamagazi.

Insulin sikuyenera kusakanikirana ndi mitundu ina ya mahomoni awa mu syringe yomweyo. Zomwezo zimagwiranso ntchito ndi mapampu a kulowetsedwa.

Kumwa mowa kumatha kuyambitsa hypoglycemia.

Ma fanizo a Glulisin ndi awa:

• Apidra
• Novorapid Flekspen,
• Epidera
• insulin isophane.

Apidra amapezeka pamankhwala. Anthu odwala matenda ashuga amapeza mankhwalawo kwaulere.

Mtengo wa cholembera sichikhala pafupifupi ma ruble 2,000.

Makatoni ndi mbale osatsegulidwa ziyenera kusungidwa mufiriji yokha. Kuzizira kwa insulin sikuloledwa. Mbale ndi ma cartridge otseguka amasungidwa pa kutentha osaposa + 25ºC.

Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu inayi, pambuyo pake uyenera kutayidwa.

Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu inayi, pambuyo pake uyenera kutayidwa.

Amapangidwa ku bizinesi Sanofi-Aventis Deutschland GmbH, Germany.

Ivan, wazaka 50, endocrinologist, ku Moscow: "Mothandizidwa ndi Apidra, ndizotheka kuyendetsa zizindikiro za glycemia mwa odwala omwe ali ndi matenda a shuga 1. Ndikupangira kuperekera insulin musanadye. Imathimitsa mayendedwe abwino a zizindikilo za shuga. ”

Svetlana, wazaka 49, wasayansi ya matenda ashuga, Izhevsk: "Glulisin ndi imodzi mwazinthu zabwino kwambiri. Odwala amalekerera bwino, koma malinga ndi kuchuluka ndi ma regimens. Hypoglycemia ndiosowa kwambiri. "

Andrei, wazaka 45, ku St. Petersburg: "Glulizin siyambitsa shuga kwambiri, zomwe ndi zofunika kwa ine monga wodwala matenda ashuga" wodziwa zambiri ". Malo pambuyo pobayidwa sikupweteka kapena kutupa. Mukatha kudya, kuwerenga kwa glucose ndikwabwinobwino. ”

Olga, wazaka 50, Tula: "Ma insulini akale ankandipangitsa kuti ndizizindikira, ndipo malowo anali opweteka. Glulisin samayambitsa zizindikiro zotere. Ndikosavuta kugwiritsa ntchito cholembera ndipo, koposa zonse, ndizothandiza. ”

Lidiya, wazaka 58, Rostov-on-Don: “Chifukwa cha Glulizin, ndimatha kudya shuga wambiri ndikatha kudya. Ndimatsata zakudya mosamala ndikuwerengera mlingo wa mankhwalawo. Palibe zochitika za hypoglycemia. ”

1. 
   Korkach V. I. Udindo wa ACTH ndi glucocorticoids pakukhazikitsa mphamvu kagayidwe, Zdorov'ya - M., 2014. - 152 p.
2. 
   Chithandizo cha Okorokov A.N. Matenda a ziwalo zamkati. Gawo 2. Chithandizo cha matenda amitsempha. Chithandizo cha endocrine matenda. Chithandizo cha matenda a impso, Mabuku a Medical - M., 2015. - 608 c.
3. 
   Matenda a kagayidwe: monograph. . - Moscow: Russia State Humanitarian University, 1987 .-- 382 p.

Ndiloleni ndidziwitse. Dzina langa ndi Elena. Ndakhala ndikugwira ntchito ya endocrinologist kwa zaka zoposa 10. Ndikukhulupirira kuti pakadali pano ndili katswiri pantchito yanga ndipo ndikufuna kuthandiza alendo onse omwe amapezeka patsamba lino kuti athetse zovuta koma osati ntchito. Zinthu zonse za tsambalo amazisonkhanitsa ndikuzikonza mosamala kuti athe kufotokoza zambiri zofunikira. Musanagwiritse ntchito zomwe zikufotokozedwa pa webusaitiyi, kufunsana ndi akatswiri ndizofunikira nthawi zonse.

Ultrashort insulin. Izi ndi chiyani?

Odwala ambiri omwe ali ndi matenda ashuga komanso omwe amafunikira timadzi tambiri timafunsidwa mafunso okhudza insulin, momwe amagwirira ntchito komanso zinthu zina zofunika kwa munthu aliyense wodwala matenda ashuga. Madotolo amakhulupirira kuti ndi mahomoni apadera ndipo akuimira chimodzi mwazomwe zakwaniritsidwa mu msika wa pharmacology m'zaka zaposachedwa.

Amasiyana mitundu ndi mitundu ya mahomoni, choyambirira, ndimathamanga ake amakhudzidwe. Muyenere kunena kuti maphunzirowa amatha kuyambira zero, mpaka mphindi 15 atabayidwa. Ndiye kuti, mankhwalawa amatha kuyamba kuchitapo kanthu akangomupatsa wodwala. Ma ultrashort analogi a insulin ndi mankhwala omwe amaperekedwa:

• novorapidom, Kapenanso insulin. Amapangidwa ku Denmark. Ndi analogue ya munthu, womwe ndi mtundu wa mankhwala osokoneza bongo. Pazomwe amapanga, njira ya biotechnology imagwiritsidwa ntchito. Pachifukwa ichi, mankhwalawa ali ndi mayamwidwe ambiri kuchokera kumalo omwe amaimiridwa ndi mafuta a subcutaneous, zomwe zimachitika mwachangu kuposa munthu sungunuka. Poyerekeza ndi omaliza, amatha kuchepetsa shuga kwambiri pakatha maola anayi atatha kudya. Odwala omwe ali ndi matenda amtundu woyamba amakhala ndi magwiridwe antchito kwambiri atatha kuyerekeza ndi insulin yaumunthu. Cholinga cha makina oyang'anira. Itha kugwiritsidwanso ntchito kudzera m'mitsetse, koma kuyang'aniridwa kwamankhwala kokhazikika kuyenera kukhazikitsidwa apa. Ndikofunikira kusintha tsamba la jakisoni. Malo omwe khoma lam'mimba ndilothandiza kwambiri kuyambitsa insulini iyi, chifukwa izi zimathandizira kuchitapo kanthu.
• humalogue, kapena apo insulin lyspro. Wopanga US. Ndizowonjezera zomwe anthu amakumbukira. Zimasiyananso ndikuti imayamba kuchita zinthu mwachangu ndipo imakhala yowonekera kwambiri nthawi yayifupi komanso nthawi yayifupi (mpaka maola asanu) ntchito ya hypoglycemic ikachitika. Kuthamanga kwa mankhwalawa (kumatenga mphindi khumi ndi zisanu atayambitsidwa) kufotokozedwa ndikuti humalog imamwa mwachangu. Izi zimapangitsa kuti zizigwiritsidwa ntchito nthawi yomweyo musanadye, nthawi zonse zimaperekedwa hafu ya ola. Mfundo imodzi yofunika kwambiri iyenera kukumbukiridwa - tsamba la jakisoni limatha kukopa kuthamanga.
• apidroy. Kapenanso insulin glulisin. Wopanga mankhwalawa ndi France. Ndizowonjezera za insulin yaumunthu, yomwe ili ndi mphamvu - yemweyo monga munthu wamba. Amadziwika ndi kuthamanga kwambiri komanso nthawi yayifupi pochitapo kanthu poyerekeza ndi insulin ya munthu wosungunuka.

Ngati mankhwalawa amaperekedwa mosavuta, ndiye kuti shuga yayamba kutsika pakatha mphindi khumi.

Onsewa ndi mitundu ya mitundu yosiyanasiyana ya insulin yaumunthu, yosinthika kwambiri poganizira ndemanga zina zomwe zimapezeka mu mahomoni ena. Ndipo, monga tanena kale, ali ndi zotsatira zochizira mwachangu kuposa njira zina zofananira.

Poyamba, mapangidwe a insulin ya ultrashort adakonza kuti zitha kupangidwira odwala okhawo omwe ali ndi matenda ashuga omwe, pazifukwa zilizonse, amatha kusiya ndikulola mafuta ena owonjezera m'zakudya zawo. Ngakhale "kupepuka" kwawo, munjira zosiyanasiyana, adzapangitsa kudumphadumpha kwamphamvu kwambiri m'magulu a shuga. Koma mosiyana ndi zoneneratu za odwala oopsa, ndizowona kuti pakati pa odwala matenda ashuga, kunalibe ambiri.

Zotsatira zake, msika udapangidwanso ndi mankhwala amakono, opangidwa bwino omwe ali ndi njira yayifupi. Ndipo tsopano ndi othandizira akhama pantchito yolimbana ndi kuchepetsa shuga ndikubwezeretsanso kwazonse. Tsopano wodwalayo ali ndi njira yodalirika komanso yothandiza ngati kudumpha kwamphamvu kapena ngati pazifukwa zina sangakhale ndi mwayi wopitilira theka la ola asadayambe chakudyacho.

Muyenera kudziwa: kugwiritsa ntchito insulin ya ultrashort ndikulimbikitsidwa pochiza odwala omwe ali ndi mitundu iwiri ya matenda ashuga, ndi kuchuluka kwa shuga atatha kudya.

Kodi mawonekedwe a mahomoni amatanthauza chiyani?

Insulin yachifupi ndi ya ultrashort ndi mahomoni apapo omwe amagwiritsidwa ntchito kuti magawo a shuga achulukane. Kutsika kwakanthawi kumayamba kuchita mkati mwa theka la ola litayambitsidwa, ndipo nsonga yofunikira imachitika pambuyo pa maola awiri. Ntchito yamahomoni a ultrashort imadziwika pambuyo pa mphindi 15-20. Zingwe zimaperekedwa musanadye m'mimba, chifukwa izi zimapangitsa kuti magazi aziyamwa mwachangu. Nthawi yochepa imayambitsidwa theka la ola musanadye, yochepa-yochepa - mphindi 5-10 musanadye kapena mutangodya.

Mfundo yogwira ntchito

Ultrashort insulin imatha kuchita zinthu mwachangu kuposa momwe wodwalayo amayamba kuyamwa mapuloteni omwe amabwera ndi chakudya ndikusintha kukhala glucose. Wodwala yemwe ali ndi regimen yoletsa zakudya sayenera kugwiritsa ntchito analogi za ultrashort.

Insulin yochepa-yochepa imagwiritsidwa ntchito, monga lamulo, ndi odwala omwe amafunika kubweretsa kuchuluka kwa glucose mwachangu kwambiri kuti ateteze kuyambika kwa zovuta zowopsa chifukwa cha zotsatira zake zazikulu. Pachifukwa ichi, amadziwika ndi iwo omwe amafunikira njira zowunikira ngati magetsi. Ndipo muzochitika zotere, ngati insulin yochepa siyigwira ntchito mokwanira, ultrashort imangokhala malo osavomerezeka.

Zimafunikanso nthawi yomwe odwala matenda ashuga amatsatira malingaliro onse a katswiri ndikumakhala ndi moyo woyenera, ndiye kuti, gasi likafika mwadzidzidzi.

Muyenera kudziwa: lero insulin yamphamvu kwambiri ndi ultrashort - imatha kuchita zinthu mwamphamvu kuposa mitundu yayifupi ya insulini kawiri, ndipo nthawi zina ochulukirapo.

Poganizira izi, wodwalayo ayenera kuganizira mosamala mlingo wa insulin iyi asanatenge mahomoni.

Ubwino ndi zoyipa

Mankhwala aliwonse kapena mankhwala ena aliwonse amakhala ndi zabwino zonse pazofanizira ndipo amakhala otsika kwa iwo mu china chake. Ultrashort insulin palinso zosiyana. Mwachitsanzo, ngati tingayerekeze momwe zimayendera ndi nthumwi yayifupi ya gululi, titha kuwona:

• Chizindikiro cha ultrashort ndikuti chiwonetsero cha zochita chimadziwoneka mwachangu, nthawi yomweyo, ndikuchepa kwa insulin kumachitika pamlingo wofanana - ndiko kuti, mwachangu kwambiri kuposa momwe wodwala amamwa mlingo wochepa wa insulin.
• Ndikofunikanso kudziwa kuti mukamagwiritsa ntchito mankhwala a insulin omwe mumapezeka, omwe, monga mukudziwa, nthawi zambiri sikungatheke kuwerengera kuchuluka kwa chakudya chopezeka m'zakudya za wodwalayo.
• Nthawi yomweyo, insulini iyi imayenera kutengedwa mphindi zochepa isanadye, ndipo iyi ndi mwayi wake pakanthawi kochepa ka insulini, komwe nthawi yopitilira theka la ola, ndikuwonetsa ntchito yake pokonza shuga. Ndipo ndizabwino kwambiri kwa odwala omwe sakudziwa nthawi yeniyeni yakudya.
• Muzochita zamankhwala, ndichidziwitso chodziwika bwino kuti ultrashort insulini sichimakhudzana ndikuchepetsa shuga glucose mosasunthika kuposa lalifupi, koma mwamphamvu kwambiri. Mankhwala ena amtunduwu, mwachitsanzo, humalogue, amatha kutsitsa chizindikiro pafupifupi nthawi ziwiri ndi theka kuposa mphamvu yayifupi. Chifukwa chake, muzochitika zotere, kusintha kwa mlingo kumafunika.

Ndizodziwikiratu kuti zosintha zonse kuti mudziwe mlingo wake ndikofunikira kuyeseza wodwalayo pafupipafupi, potengera momwe adawerengera. Ndipo izi ndizofunikanso.

Zina mwazotsatira zoyipa za mankhwalawa, zofala kwambiri, mwachitsanzo, ku Novorapid ndikokula kwa hypoglycemia. Pali ena. Muyenera kudziphunzira nawo mosamala musanagwiritse ntchito izi ndi njira zina.

Ndipo tchuthi ndi pakati

Odwala nthawi zambiri amakhala alibe mikhalidwe yambiri, pakakhala kufunika kwa mankhwala othamanga kwambiri. Pali ambiri a iwo, mwachitsanzo, kusowa koteroko kumatha kubwera mukapita ku malo odyera kapena kuyenda mu eyapoti, pomwe zakudya zimakhala zosiyana panthawi yomwe wodwalayo ankadya. Ndi nkhani ngati izi kuti mankhwala a ultrashort ndi chida chofunikira kwambiri.

Kafukufuku awonetsa kuti odwala omwe, akamagwiritsa ntchito zakudya zoyenera komanso zakudya, amagwiritsa ntchito insulin ya inshuwaransi, kulimba kwa shuga awo kumafikira zana limodzi.

Chofunika kwambiri ndikugwiritsa ntchito insulin iyi kwa odwala omwe ali ndi matenda osokoneza bongo panthawi ya pakati. Kodi thandizo lake ndi lotani makamaka pamenepa, monga tafotokozera m'munsimu:

• imakhala ndi vuto lalikulu la hypoglycemia ya usiku, ikuchepetsa pafupipafupi zochitika zake. Izi ndizofunikira makamaka kwa trimester yoyamba,
• pa gawo la cesarean, zimathandiza mkazi kuti asadwale, chifukwa amatenga msanga,
• chiopsezo chotenga hypoglycemia atatha kudya kuchepetsedwa,
• ngakhale pamaso pa toxicosis kumayambiriro kwa mimba chifukwa cha katundu yemwe ali ndi mankhwala, wodwalayo saloledwa kugwiritsa ntchito mankhwalawa.

Pomaliza

Tsopano popeza tikudziwa komwe ndi komwe insulin ili imathandizira, titha kulandira zomwe ali nazo. Zitha kufotokozedwa motere:

• amachepetsa kukula kwa mlingo,
• kumawonjezera kulimba kwa wodwala, kuthandiza kukonza zambiri,
• Imasiya kudumpha pafupipafupi m'magulu a shuga,
• imayang'anira matendawa.

Kodi ndichifukwa chiyani ndikofunikira kuyang'anira ndikuwonetsetsa kuchuluka kwa shuga m'magazi? Chifukwa ngati ikutsikira ku 3.2, izi zimayambitsa kukulitsa kwa hypoglycemia. Ndipo izi, zimayambitsa kukhumudwitsidwa mu ziwalo zonse za odwala ndi machitidwe a wodwala, ubongo uyamba kukhudzidwa. Zizindikiro zimawoneka, zikuwonetsedwa pakufooka kwamphamvu kwa thupi, kumverera kosalekeza, chizungulire. Kuwonetsedwa kwamphamvu kwa miyendo ndi chisokonezo ndizotheka. Zikuwonekeratu kuti pamenepa, wodwalayo sangathe kugwira ntchito. Kuphatikiza apo, ngati matendawa apita patsogolo, ndiye kuti ndiwofupi ndi kukula kwa vuto la hypoglycemic.

Mwazi wa shuga ukakwera kufika pa 5.6 kapena kupitilira, nthawi zambiri zimapangitsa kukula kwa hyperglycemia. Kukula kwakanthawi kochepa sikumawopseza wodwala zovuta zilizonse zowopsa, chifukwa izi ndi zachilengedwe komanso zomveka zomwenso zimachitika pambuyo podya, makamaka chakudya chikadzaza ndi chakudya. Koma ngati zodabwitsazi ndizokhazikika, zitha kuonedwa ndi matenda ashuga.

Yang'anirani thanzi lanu nthawi zonse. Pumulani kwambiri.Pitani kwa dokotala pafupipafupi, kufunsani pazinthu zatsopano zilizonse mukalandira chithandizo. Ndipo kenako machiritso apita mwachangu kwambiri.

Fiqu, Fiasp

Wopanga: Novo Nordisk (Denmark), Novo Nordisk (Denmark)

Dzinalo: Fiasp ®, Fiasp ® (insulin aspart)

Machitidwe
Fiasp® imakhala ndi kuyamba komanso kufupikira kwakanthawi kuposa Novorapid. Itha kuperekedwa nthawi yomweyo musanadye. Ngati ndi kotheka, Fiasp ® imatha kuperekedwanso pambuyo chakudya.

Zisonyezero zogwiritsidwa ntchito:
Mtundu woyamba wa shuga.
Type 2 shuga.

Njira yogwiritsira ntchito:
Fiasp imayendetsedwa pang'onopang'ono m'chigawo cha khomo lakunja kwam'mimba, ntchafu, phewa, matako.
Mankhwalawa amaperekedwa nthawi yomweyo musanadye, zakudya kapena mutangodya.
(zina ...)

Rosinsulin P

Dzinalo - Rosinsulin P
Wopanga - Honey Synthesis (Russia)

Machitidwe
Mankhwalawa akuchita mwachidule.

Zisonyezero zogwiritsidwa ntchito:
Mitundu ya matenda a shuga a insulin. Kutsutsa kwa othandizira a hypoglycemic. Kuphatikiza mankhwala ndi m`kamwa hypoglycemic wothandizira. Mimba yokhala ndi matenda osokoneza bongo omwe samatengera insulin. (zina ...)

Wopanga - Sanofi-Aventis (France), Sanofi

Mutu: Apidra ®, Apidra ®

Dzinalo: Insulin Glulisin

Zopangidwa:
1 ml ya mankhwalawa muli insulin glulisin 3.49 mg ndi zotupa: m-cresol, sodium chloride, trometamol, polysorbate 20, moyikirapo hydrochloric acid, sodium hydroxide (mpaka pH 7.3), madzi d / ndi.

Machitidwe
Apidra (insulin glulisin) ndi njira yofananira ya insulin yaumunthu, yofanana ndi mphamvu kwa insulin wamba ya anthu. Insulin glulisin imayamba kuchita zinthu mwachangu ndipo imakhala ndi nthawi yofupikirapo kuposa insulin ya munthu wosungunuka.
Ndi subcutaneous makonzedwe, zochita za Apidra, zomwe zimatsitsa kuchuluka kwa shuga m'magazi, zimayamba mphindi 10-20.
Apidra imayendetsedwa ndi jakisoni wofinya kapena kulowetsedwa kosalekeza m'mafuta onunkhira pogwiritsa ntchito pampu, posachedwa (0-15 mphindi) kapena atangodya.

Zisonyezero zogwiritsidwa ntchito:
Matenda a shuga odwala matenda a insulin odwala akuluakulu.
(zina ...)

Humalog, Humalog

Wopanga: Eli Lilly, Eli Lilly (USA)

Mutu: Humalog ®, Humalog ®

Dzinalo: Lyspro insulin

Zopangidwa: 1 ml ya mankhwalawa muli - 40 PIERES kapena 100 PIERES. The yogwira pophika ndi yankho la ndale Lieproinsulin, analogue wa anthu insulin.

Machitidwe DNA imabweretsanso insulin ya anthu. Amasiyana ndi omaliza mwanjira zotsatizana za amino acid pamalo 28 ndi 29 a insulin B.

Humalog imadziwika ndi kuyamba mwachangu, kuyambika koyambirira kwa kanthu komanso nthawi yayifupi ya zochitika za hypoglycemic (mpaka maola 5) poyerekeza ndi insulin yodziwika bwino ya anthu. Kuyamba koyamba kwa mankhwalawa, pafupifupi mphindi 15 pambuyo pa kupangika, kumalumikizidwa ndi mayamwidwe ambiri. Izi zimakuthandizani kuti mulowetse mankhwalawa musanadye (mphindi 15), mosiyana ndi insulin wamba, yomwe imaperekedwa kwa mphindi 30 musanadye. Mlingo wa mayamwidwe a insulin lispro ndipo chifukwa chake, kuyambika kwa zochita zake kungakhudzidwe ndi kusankha kwa malo a jekeseni.
(zina ...)

Novorapid, NovoRap>

Wopanga: Novo Nordisk (Denmark), Novo Nordisk

Dzinalo: Novorapid ® (insulin aspart), NovoRapid ®

Zopangidwa: 1 ml ya Novorapid ® imakhala ndi: yogwira mankhwala: insulin aspart 100 U, yopangidwa ndi njira ya DNA yogwirizananso ndi michere ya Saccharomyces cerevisiae.

Machitidwe NovoRapid ndi analogue yaifupi yochepa yogwira insulin yopangidwa ndi recombinant DNA biotechnology pogwiritsa ntchito Saccharomyces cerevisiae kupsinjika komwe amino acid proline m'malo a B28 m'malo mwake ndi aspartic acid.

Imalumikizana ndi cholandirira chapadera pa cytoplasmic membrane wa maselo ndikupanga insulini-receptor zovuta zomwe zimapangitsa njira zamkati, kuphatikiza kapangidwe kazinthu zingapo za enzymes (hexokinase, pyruvate kinase, glycogen synthetase, etc.). Kutsika kwa shuga m'magazi kumachitika chifukwa cha kuchuluka kwa kayendedwe kazinthu zosafunikira, kuchuluka kwa minofu, kukondoweza kwa lipogenesis, glycogenogeneis, kuchepa kwa kuchuluka kwa shuga ndi chiwindi, zina. yothetsera yokhazikika insulin. Motere, NovoRapid imatengedwa mwachangu kuchokera kumafuta amkati ndipo imayamba kuchita zinthu mwachangu kuposa insulin yamunthu. NovoRapid ® imachepetsa shuga wamagazi kwambiri maola 4 atatha kudya kusiyana ndi insulin yaumunthu. Odwala omwe ali ndi vuto la matenda a shuga 1, amachepetsa shuga a m'magazi am'mimba ndipo amadziwika ndi NovoRapid, poyerekeza ndi insulin yaumunthu.
(zina ...)

Zinthu zazifupi ndi insulin

Homoni yocheperako imapangidwa pamaziko a mahomoni ofanana a nyama, nthawi zambiri amakhala nkhumba, kapena biosynthesis. Izi zimakuthandizani kuti muubweretse pafupi ndi mawonekedwe a chilengedwe, mahomoni amunthu ndikufulumizitsa mphamvu yochiritsa. Insulin yochepa imangoperekedwa ndi syringe yapadera, nthawi iliyonse m'malo osiyana, koma nthawi yomweyo. Ultrashort - njira yatsopano mu ukadaulo wa zamankhwala ndi pharmacology. Kukonzekera kwa Ultrashort kumapangidwa pamaziko a mahomoni amunthu ndikusintha. Poyamba, mankhwalawa adapangidwa kuti azisamalira odwala omwe amadwala matenda ashuga omwe amadya zakudya zamagulu ena kapena zakudya zina zomwe zimadzetsa kulumpha kowopsa m'magazi a magazi. Koma adayamba kugwiritsa ntchito mtundu wamtunduwu mu mankhwala ovuta.

Ubwino ndi kuipa

Mtundu uliwonse wa mankhwalawo uli ndi zabwino komanso zoyipa. Kuunika insulin yayifupi, zomwe zimawonetsedwa patebulopo zimawunikidwa:

Mwa zina mwa mankhwala osokoneza bongo a insulin, "Insuman Rapid", "Humulin", "Actrapid" ndi "Homor" ndi amodzi. Zochita zawo ndizofanana ndi za insulin ya munthu. "Humulin" imasiyana ndi ina pakugwiritsa ntchito kwake mtundu wa 1 ndi mtundu wa 2 shuga, amavomerezedwa kuti azigwiritsidwa ntchito panthawi yapakati. Kuphatikiza apo, amawerengedwa kwa odwala omwe ali ndi ketoocytosis komanso panthawi ya opareshoni.

Insulin yotchuka kwambiri ya ultrashort ndi Humalog, yotsatiridwa ndi mankhwala otchuka, omwe mayina awo ndi Apidra ndi Novorapid. Humalog yatengera yankho la lieproinsulin, Apidra insulin glulisin, ndi Novorapida insulin aspart. Aliyense wa iwo amachita monga momwe munthu amatengera kwakanthawi. Kugwiritsa ntchito moyenera mankhwalawa popanda kuphwanya zakudya kumapangitsa kuti shuga azikhala wolimba m'magazi. Mitundu ya Ultrashort ndi njira yabwino kwa amayi omwe ali ndi chidwi, chifukwa amatha kugwiritsidwa ntchito panthawi yobereka komanso panthawi yonse yoyembekezera, popanda kuyambitsa zovuta.

Kodi zikuwonekabe zosatheka kuchiritsa matenda ashuga?

Poona kuti mukuwerenga izi tsopano, kupambana polimbana ndi shuga wambiri sikuli kumbali yanu.

Ndipo mudaganizapo kale za chithandizo kuchipatala? Ndizomveka, chifukwa shuga ndi matenda oopsa, omwe, ngati sanapatsidwe, amatha kufa. Udzu wokhazikika, kukodza mwachangu, masomphenya osalala. Zizindikiro zonsezi mumazidziwa nokha.

Koma kodi ndizotheka kuchitira zomwe zimayambitsa m'malo mothandizira? Timalimbikitsa kuwerenga nkhani yokhudza matenda aposachedwa a shuga. Werengani nkhani >>