(dzina lachiwiri ndi alpha lipoic).

Chofunikira chachikulu ndicho antioxidant chofunikira thupi kuti chizithandiza kwathunthu.

Matenda omwe akuwonetsedwa ndi zakumwa, zakumwa zoledzeretsa zam'mitsempha, kuledzera kwambiri kwa thupi. Kuchuluka kwa asidi kumeneku kumapangidwa modziyimira pawokha, koma kwa zaka zambiri, msanga wopanga umachepa, ndipo kufunikira kumawonjezeka. Kuphatikiza ndi alpha lipoic acid kumatha kuchiritsa matenda ndikusintha moyo wabwino.

Kukonzekera kwa Thioctic acid kumapezeka mwa mapiritsi, ma rectal suppositories, njira yopangira jekeseni ndi chinthu cholimba pokonzekera yankho. Mankhwala opangidwa ndi alpha-lipoic acid amatsanulidwa kuchokera kuzipatala mwa mankhwala okha.

Ma analogi a Thiogamm amapangidwa ndi makampani opanga mankhwala m'mayiko angapo. Timalemba zomwe zili wamba mumsika wathu.

• Corilip
• Corilip Neo
• Lipoic acid
• Lipothioxone
• Tiolepta.

• 300 (Germany),
• Berlition 600 (Germany),
• Neyrolipon (Ukraine),
• Thioctacid 600 T (Germany),
• Thioctacid BV (Germany),
• Espa Lipon (Germany).

Thiogamma kapena Thioctacid?

Thioctacid ndi mankhwala ofanana potengera zomwe zimagwira.

Mawonekedwe a Thioctacid ndi oyenera:

• Chithandizo cha neuropathies,
• matenda a chiwindi
• mafuta kagayidwe kachakudya,
• atherosulinosis,
• kuledzera,
• kagayidwe kachakudya matenda.

Pambuyo pofufuza wodwalayo ndikukhazikitsa njira yodziwikiratu, dokotalayo amapanga dongosolo lakumwa mankhwalawo. Monga lamulo, chithandizo chimayamba ndi kuperekedwa kwa ma ampoules a mankhwala a Thioctacid 600 T pa 1600 mg kwa masiku 14, kenako kutsanulira pakamwa kwa Thioctacid BV, piritsi limodzi patsiku musanadye.

Mawonekedwe a BV (kutulutsidwa mwachangu) amatha kubwezeretsa jakisoni wamkati, chifukwa amalola kuwonjezeka kwa gawo logwira ntchito. Kutalika kwa chithandizo ndikutalika, chifukwa thupi limayenera kulandira zinthu zogwira ntchito nthawi zonse, kuti lizigwira bwino ntchito.

Mapiritsi a Thioctacid

Mukamaperekedwa kudzera m'mitsempha, kuchuluka kwa mankhwala olowa mthupi ndikofunikira. Mbale umodzi amaperekedwa kwa mphindi 12, popeza mlingo woyendetsedwa ndi mankhwalawa ndi 2 ml pa mphindi. Thioctic acid imabweza kuwala, kotero ma ampoule amachotsedwa phukusi lokha lisanachitike.

Poyendetsa bwino, Thioctacid itha kugwiritsidwa ntchito popukutidwa. Pachifukwa ichi, kuchuluka kwa mankhwalawa kumasungunuka mu 200 ml ya saline yamoyo, kuteteza botolo kuti lisawone ndi kulowa kulowa m'magazi kwa mphindi 30. Ngakhale kuti imatetezedwa moyenera ndi dzuwa, Thioctacid wosungidwa amasungidwa kwa maola 6.

Mankhwala osokoneza bongo amawoneka ndi mitundu yayikulu ya mankhwala, zomwe zimapangitsa kuledzera. Amatsimikiziridwa ndi nseru, kusanza, kupweteka mutu, ziwalo zingapo, kulephera kwamatenda, thrombohemorrhagic syndrome, hemolysis ndi mantha.

Kumwa panthawi yachipatala kumaphwanya, chifukwa kumayambitsa poizoni, kukomoka, kukomoka, ndikutha kufa.

Ngati zizindikirozi zapezeka, kugonekedwa kuchipatala munthawi yake komanso machitidwe kuchipatala oyembekezeredwa kuti atulutsidwe ndikofunikira.

Mukamayambitsa kulowetsedwa kwa Thioctacid 600 T, zotsatira zoyipa zimachitika mankhwala akaperekedwa mwachangu.

Kutembenuka kumatha kuchitika, mwina kukuwonjezeka kwa kukakamizidwa kwa intracranial, apnea. Ngati wodwalayo amakhala ndi vuto lakelo chifukwa chodwala, ndiye kuti mawonekedwe a khungu lawo samayatsidwa, mwachitsanzo, zotupa za pakhungu, kuyabwa, anaphylaxis, edema ya Quincke. Pali mwayi wofanana ndi vuto la kupatsidwa zinthu za m'magazi, kuwoneka kwa magazi mwadzidzidzi, kutsina kukhathamiritsa pakhungu.

Mukamamwa mapiritsi a Thioctacid B, nthawi zina odwala amasokonezeka ndi kupukusira m'mimba: nseru, kusanza, gastralgia, kusagwira bwino matumbo. Chifukwa cha katundu wa Thioctacid, ma ayoni azitsulo ndi zinthu zina zaumwini zimamangidwa pamodzi ndi chitsulo, calcium, magnesium kapena ma protein a mineral mineral omwe amaphatikizidwa.

Anthu omwe amamwa kapena kumwa mankhwala kuti achepetse magazi awo ayenera kukumbukira kuti asidi wa thioctic amawonjezera kugwiritsidwa ntchito kwa shuga, motero muyenera kuyang'anitsitsa kuchuluka kwanu kwa shuga ndikuwonetsetsa kuchuluka kwa zinthu zomwe zimachepetsa shuga.

Chifukwa cha kupezeka kwa mankhwala osungunuka pang'ono, Thioctacid samasakanizidwa ndimayankho a Ringer, monosaccharides ndi mayankho a magulu a sulfide.

Poyerekeza ndi Tiogamma, Thioctacid ali ndi zotsutsana zochepa, zomwe zimaphatikizapo kuyamwitsa kokha, kulera mwana ndi kusalolera payekha pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwalawa.

Kodi pali chilichonse chotsika mtengo komanso chabwino kuposa Tiogamm? Kuwunika kwa analogi ndi kuyerekezera kwa mankhwala. Tiogamm analogues ndi mitengo

Tiogamm: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Thiogamm

Code ya ATX: A16AX01

Zosakaniza: Thioctic acid (Thioctic acid)

Wopanga: Verwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Germany

Sinthani mafotokozedwe ndi chithunzi: 05/02/2018

Thiogamma ndi mankhwala omwe amawongolera metabolidi ya lipid ndi carbohydrate.

Kodi pali chilichonse chotsika mtengo komanso chabwino kuposa Tiogamm? Kuwunika kwa analogi ndi kuyerekezera kwa mankhwala. Mankhwala osokoneza bongo komanso malangizo apadera. Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Thiogamma ndi mankhwala a antioxidant komanso metabolic omwe amawongolera chakudya cham'mimba komanso lipid metabolism.

Zomwe zimagwiritsa ntchito mankhwalawa ndi thioctic (alpha-lipoic) acid. Ndi ma antioxidant amkati omwe amamangirira zopitilira muyeso. Thioctic acid imapangidwa m'thupi nthawi ya oxidative decarboxylation ya alpha-keto acid.

Thioctic acid amawongolera chakudya komanso lipid metabolism, imakhudza ntchito ya chiwindi komanso imathandizira kagayidwe ka cholesterol. Ili ndi hypolipidemic, hypoglycemic, hepatoprotective ndi hypocholesterolemic kwenikweni. Chimalimbikitsa thanzi la neurons.

Alpha-lipoic acid imathandizira kuchepetsa shuga m'magazi, kuonjezera kuchuluka kwa glycogen m'chiwindi ndikugonjetsa insulin kukana. Mwa makina ochitira, ili pafupi ndi mavitamini a gulu B.

Kafukufuku wokhudza makoswe omwe ali ndi matenda a shuga a streptozotocin adawonetsa kuti asidi wa thioctic amachepetsa mapangidwe a glycation omaliza, amasintha magazi am'magazi, ndikuwonjezera kuchuluka kwa antioxidants achilengedwe monga glutathione. Umboni waukadaulo umati thioctic acid imathandizira kuti zotumphukira za neuron zizigwira ntchito.

Izi zimagwira ntchito pazovuta zamatenda a matenda ashuga polyneuropathy, monga dysesthesia, paresthesia (kuwotcha, kupweteka, kukwawa, kuchepa mphamvu). Zotsatira zake zimatsimikiziridwa ndi mayesero azachipatala a multicenter omwe adachitika mu 1995.

Mitundu yotulutsidwa kwa mankhwalawa:

• Mapiritsi - 600 mg yogwira ntchito iliyonse,
• Njira yothetsera makulidwe a makolo 3%, ampoules a 20 ml (mu 1 ampoule 600 mg yogwira ntchito),
• Thiogamm-turbo - njira yothetsera kulowetsedwa kwa kholo 1.2%, 50 ml Mbale (mu 1 botolo 600 mg yogwira ntchito).

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandizira chiyani Tiogamm? Lembani mankhwalawa mu milandu iyi:

• Matenda a chiwindi chamafuta (mafuta a chiwindi),
• Hyperlipidemia yachidziwitso chosadziwika (mafuta okwera)
• Poyizoni wazipale (kuwonongeka kwa chiwindi),
• Kulephera kwa chiwindi
• Matenda a chiwindi cha chidakwa komanso zotsatira zake,
• Hepatitis kuchokera kulikonse,
• Hepatic encephalopathy,
• Matenda a chiwindi.

Malangizo ogwiritsira ntchito Thiogamm, mlingo

Mapiritsi amatengedwa pakamwa, pamimba yopanda kanthu, kutsukidwa ndi madzi pang'ono.

M'chaka, njira ya mankhwalawa imatha kubwerezedwa katatu.

Mankhwala chikuyendetsedwera iv muyezo wa 600 mg / tsiku (1 amp. Gwiritsirani ntchito pokonzekera yankho la kulowetsedwa kwa 30 mg / ml kapena 1 botolo la yankho la kulowetsedwa kwa 12 mg / ml).

Mukamayambitsa kulowetsedwa kwa mtsempha, mankhwalawa amayenera kuperekedwa pang'onopang'ono, osaposa 50 mg / min (omwe ali ofanana ndi 1.7 ml ya kuganizira kwambiri pokonzekera yankho la kulowetsedwa kwa 30 mg / ml).

Konzani njira yothetsera kulowetsedwa - zomwe zili mumulu umodzi wa zomwe mukumangirira ziyenera kusakanikirana ndi 50-250 ml ya 0,9% sodium kolorayidi. Botolo lomwe lili ndi njira yokonzekereratu limakutidwa ndi vuto lotetezera, lomwe limakhala lathunthu ndi mankhwalawo. Yankho lokonzeka likhoza kusungidwa osaposa maola 6.

Ngati njira yothetsera kulowetsedwa okonzeka itagwiritsidwa ntchito, botolo la mankhwalalo limachotsedwa m'bokosilo ndipo nthawi yomweyo limakutidwa ndi kesi yoteteza. Kuyambitsa kumapangidwa mwachindunji kuchokera m'botolo, pang'onopang'ono - kuthamanga kwa 1.7 ml / miniti.

Zotsatira zoyipa

Thiogamma ikhoza kukhala yokhudzana ndi zotsatirazi:

Kuchokera pamimba: mukamwa mankhwalawa mkati - dyspepsia (kuphatikiza mseru, kusanza, kutentha kwa mtima).

• Kuchokera kumbali ya dongosolo lamkati lamanjenje: kawirikawiri (pambuyo pa kayendetsedwe ka iv) - kupweteka, diplopia, ndikuwongolera mwachangu - kukhudzidwa kwachulukidwe (kuwoneka ngati kolemetsa m'mutu).
• Kuchokera pamagazi ophatikizika am'magazi: kawirikawiri (pambuyo pa utsogoleri wa iv) - amaloze zotupa mu mucous nembanemba, khungu, thrombocytopenia, hemorrhagic zidzolo (purpura), thrombophlebitis.
• Kuchokera pamachitidwe opumira: poyambira / poyambitsa, zovuta kupuma ndizotheka.
• Thupi lawo siligwirizana: urticaria, zokhudza zonse zimachitika (mpaka chitukuko cha anaphylactic mantha).
• Ena: hypoglycemia imatha kupezeka (chifukwa cha kutulutsa shuga).

Contraindication

Thiogamma amatsutsana pazochitika zotsatirazi:

• ana ndi achinyamata osakwana zaka 18,
• nthawi yapakati
• Nthawi yonyamula mkaka
• glucose-galactose malabsorption, kuchepa kwa lactase, chibadwa cha galactose tsankho (mapiritsi),
• Hypersensitivity kwa zida zazikulu kapena zothandiza za mankhwalawa.

Poyerekeza ndi momwe mankhwalawo amagwiritsidwira ntchito, mankhwalawa sangatengedwe, popeza mothandizidwa ndi ethanol, mwayi wokhala ndi zovuta kwambiri kuchokera kumitsempha yam'mimba komanso kugaya kwam'mimba kumawonjezereka.

Mitengo ku pharmacies aku Moscow: Njira ya Thiogamma 12 mg / ml 50 ml - kuyambira 197 mpaka 209 rubles. Mapiritsi a 600 mg 30 ma PC. - kuchokera ku 793 mpaka 863 ma ruble.

Pewani patali ndi ana, mutetezedwe ndi kuwala, kutentha mpaka 25 ° C. Moyo wa alumali ndi zaka 5. Mankhwala, mankhwala amapezeka.

The fanizo la thiogamm ya mankhwala imaperekedwa, malinga ndi tanthauzo lachipatala lomwe limatchedwa "ma syonyms" - mankhwala osinthika omwe ali ndi chinthu chimodzi kapena zingapo zomwe zimagwira ntchito mothandizidwa ndi thupi. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.

Kufotokozera za mankhwalawa

Monga coenzyme ya mitochondrial multenzyme complexes, imakhudzidwa ndi oxidative decarboxylation ya pyruvic acid ndi alpha-keto acid. Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera zomwe glycogen imayambira m'chiwindi, komanso kuthana ndi insulin.

Amatenga nawo gawo la lipid ndi carbohydrate metabolism, imakhudzanso cholesterol metabolism, imayendetsa ntchito ya chiwindi, imatha kusintha poizoni ndi mchere wambiri ndi zakumwa zina zoledzeretsa. Ili ndi hepatoprotective, hypolipidemic, hypocholesterolemic ndi hypoglycemic. Amakweza ma neuroni a trophic.

Mu matenda a shuga a shuga, thioctic acid imayenda bwino m'magazi am'magazi, kumawonjezera kuchuluka kwa glutathione kukhala phindu lanyama, zomwe zimapangitsa kusintha mu magwiridwe antchito a zotupa zamitsempha yamagazi mu diabetesic polyneuropathy.

Mndandanda wazofananira

Tcherani khutu! Mndandandandawu umakhala ndi mawu ofanana a Tiogamma, omwe ali ndi mawonekedwe ofanana, kotero mutha kusankha nokha m'malo mwake, mukuganizira mawonekedwe ndi mankhwalawa omwe mankhwalawo adauzidwa ndi adotolo. Perekani zokonda kwa opanga ku USA, Japan, Western Europe, komanso makampani odziwika bwino ochokera ku Eastern Europe: Krka, Gideon Richter, Actavis, Aegis, Lek, Hexal, Teva, Zentiva.

Alendo 28 adafotokoza za kudya tsiku lililonse

Kodi ndiyenera kumwa kangati ka Thiogamma?
Ambiri omwe amayankhidwa nthawi zambiri amamwa mankhwalawa 1 kamodzi patsiku. Ripotilo likuwonetsa kuti anthu ena omwe amayankha mankhwalawa amamwa kangati

Alendo 33 adafotokoza

Alendo asanu adanenanso za kumaliza ntchito

Kodi zimatenga nthawi yayitali bwanji kuti a Thiogamma amve bwino?
Ochita kafukufuku mu nthawi zambiri atatha mwezi umodzi adasintha. Koma izi sizingafanane ndi nthawi yomwe musinthe. Funsani dokotala wanu kuti mupeze mankhwalawa kwa nthawi yayitali bwanji. Gome ili pansipa likuwonetsa zotsatira za kafukufuku pa zoyambira kuchitapo kanthu.

Alendo asanu ndi atatu adauza nthawi yolandila

Nthawi yabwino kwambiri yotenga Tiogamm ndi iti: pamimba yopanda kanthu, isanachitike, itatha, kapena ndi chakudya?
Ogwiritsa ntchito mawebusayiti nthawi zambiri amati amamwa mankhwalawa pamimba yopanda kanthu. Komabe, adotolo atha kuvomereza nthawi ina. Ripotilo likuwonetsa pamene ena onse omwe adawafunsidwa amamwa mankhwalawo.

Migwirizano ya Tchuthi

Zomwe zili patsamba lino zinatsimikiziridwa ndi katswiri wazachipatala Vasilieva E.I.

Thiogamma ndi njira yowongolera chakudya cham'mimba komanso lipid metabolism. Fotokozerani mankhwalawa kwa odwala matenda ashuga. Kuphatikizikako kumaphatikizapo thioctic acid. Wopezeka mu mawonekedwe a mapiritsi, amagwiritsa ntchito njira zothetsera mavuto ndi iwo eni. Mankhwalawa amaperekedwa ndi mankhwala.Ganizirani chisonyezo chachikulu, komanso thiogamma, malangizo ogwiritsira ntchito, mtengo, ndemanga, analogues.

Matenda a shuga a polyneuropathy

Zisonyezero zogwiritsidwa ntchito Tiogamma 600 ndi matenda a shuga a polyneuropathy. Amayamba kukhala ndi anthu odwala matenda ashuga. Zimathanso kuchitika matendawa asanayambike. Imawonekera ngati kusintha kwa minyewa yamanjenje, kupweteka kwamitundu yosiyanasiyana ndi mphamvu, kumverera kwa kugunda, kumva thukuta mthupi lonse, koma nthawi zambiri kumiyendo.

Mankhwalawa amaperekedwa kuti athetse zizindikiro, kusintha kwamphamvu kwa minyewa yamitsempha, komanso kupewa kuteteza zovuta, kuphatikizapo zilonda zam'mimba.

Zomwe madokotala amakamba za makwinya

Dokotala wa Sayansi Yachipatala, Opanga Opaleshoni Morozov EA:

Ndakhala ndikuchita opareshoni ya pulasitiki kwazaka zambiri. Anthu ambiri otchuka omwe amafuna kuti aziwoneka ngati achichepere amadutsa ine. Pakadali pano, opaleshoni ya pulasitiki ikutaya kufunika kwake chifukwa sayansi siyimayima, njira zochulukirachulukira zatsopano zopangitsanso thupi zimawonekera, ndipo zina mwa izo ndi zothandiza. Ngati simukufuna kapena mulibe mwayi woti muchite opaleshoni ya pulasitiki, ndikupangira njira yofananira, koma yotsika mtengo kwambiri momwe mungathere.

Kwazaka zoposa 1 tsopano, mankhwala ozizwitsa a kukonzanso khungu NOVASKIN, omwe angapezeke, akhala ali pamsika waku Europe ZAULERE . Pakugwiritsa ntchito bwino, ndikofunikira kangapo kuposa jakisoni wa Botox, osanenapo mafuta amitundu yonse. Ndiosavuta kugwiritsa ntchito ndipo chinthu chake chofunikira kwambiri chomwe mudzachiona nthawi yomweyo. Popanda kukokomeza, ndinena kuti makwinya ang'ono ndi akuya, matumba pansi pamaso amadutsa pafupifupi nthawi yomweyo. Chifukwa cha kukhudzika kwa khungu, khungu limabwezeretseka kwathunthu, kusinthidwa, zosintha zimangokhala zazikulupo.

Zomwe zimayambitsa matendawa zimawonedwa ngati njira yochizira matenda ashuga. Makamaka:

• Mwazi wa magazi umayambitsa kusokonezeka thupi lonse.
• Kuperewera kwa zakudya m'thupi, hypoxia,
• Kuchepetsa kwamankhwala michere ndi mavitamini,
• Kubwereza pafupipafupi kwa matenda ashuga.

Ndi chitukuko cha matenda ashuga, polyneuropathy imakhazikika ndipo pamapeto pake imatha kusintha. Pali magawo angapo a matendawa: subclinical, clinical.

Pa subclinical, yomwe ili gawo loyamba, nthawi zambiri makamaka sazindikira zizindikiro - kunenepa kochepa.

Pa gawo lachiwiri, zamankhwala, zizindikiro zosiyanasiyana zimawonekera kale kutengera mtundu wa matendawa - kupweteka pachimake, kupweteka kosatha, kupweteka, amyotrophic.

Mu gawo lachitatu, zovuta zikukula. Chimodzi mwa izo ndi zilonda zam'mapewa. Mu 15% ya odwala, madera omwe akukhudzidwawa akuyenera kuchotsedwa, ndiye kuti, kudula kumachitika. Polyneuropathy amathandizidwa ndimankhwala angapo, kuphatikizapo:

• Mavitamini
• Alpho-Lipolic Acid,
• Aldose reductase inhibitors,
• Mankhwala opweteka
• Actovegin,
• Maantibayotiki (ngati pali wothandizira)
• Calcium ndi potaziyamu kukonzekera.

Pharmacokinetics ndi pharmacological kanthu

Ichi ndi metabolic othandizira omwe amakhala ndi amkati antioxidant omwe amamangirira zopitilira muyeso. Ndi chithandizo chake, zinthu zofunika ndi ma asidi zimapangidwa m'thupi la wodwalayo. Imagwiranso ntchito ngati coenzyme, kutenga nawo mbali m'magulu a oxidative. Zimathandizira kuchepetsa shuga wamagazi ndikuwonjezera milingo ya glycogen m'chiwindi. Ndi chithandizo chake, ndizotheka kuthana ndi insulin kukana.

Thioctic acid ku Thiogamm ndiwofanana mu biochemistry ndi mavitamini B. Amathandizira kutenga nawo gawo la carbohydrate ndi lipid metabolism, amathandizira kagayidwe ka cholesterol, komanso kukonza chiwindi. Chifukwa chake, chiwopsezo cha chiwindi chimawonekera, komanso hypoglycemic, hypocholesterolemic ndi hypolipidemic zotsatira. Mu neurons, trophism imayenda bwino. Popeza mtengo, malangizo ogwiritsira ntchito, Thiogamma mwa njira yankho la iv amathandiza kuchepetsa mavuto komanso amathandizira kukonza thanzi.

Mutatenga piritsi ya Tiogamma, thioctic acid imakhala pafupi kwathunthu komanso mwachangu kudzera m'mimba. Ngati mumatenga piritsi nthawi yomweyo ndi chakudya, ndiye kuti mayamwidwe amachepetsa kwambiri, amatenga ola limodzi. Komanso, bioavailability ndi 30%. Ndi jakisoni wamkati, Thiogamm, malinga ndi madokotala, amamwetsedwa kwathunthu mu mphindi 10-11.

Mankhwala amapita woyamba-zotsatira, kupanga metabolites. Amatsitsidwa ndi impso ndi 90%. Hafu ya moyo ndi mphindi 20-50, kutengera mawonekedwe a thupi la wodwalayo.

Kugwiritsa

Mankhwalawa amaperekedwa pakamwa pa 300-600 mg kamodzi patsiku. Mapiritsi amatengedwa popanda kutafuna ndi madzi ochepa. Mankhwalawa amaperekedwa kudzera mu mtsempha wa 600 mg. Kumayambiriro kwenikweni kwa mankhwalawa, kukonzekera kwamankhwala kumalimbikitsidwa. zimachitika tsiku lililonse kwa masabata 2-4, kutengera ndi zomwe dokotala akuwonetsa. Pambuyo mankhwala kutumikiridwa pakamwa mu mawonekedwe a piritsi ya Tiogamm mu 300-600 mg. Mankhwalawa akaperekedwa kudzera m'mitsempha, ndikofunikira kuchita njirayo pang'onopang'ono - 50 mg / min.

Malinga ndi malangizo a Thiogamma Turbo amathandizira paubwino wa makolo ngati yankho.

Lemberani milandu ngati kuphwanya kwamvekedwe kwamveka kale ndipo kumayenderana ndi matenda a shuga.

Ngati kugwirizanitsa kumasakanizidwa ndi zosungunulira, wothandizirayo amatumizidwa nthawi yomweyo kuti azigwira bwino ntchito. Onetsetsani kuti mwateteza yankho ku dzuwa.

Pafomu ya piritsi, mankhwalawa amagwiritsidwa ntchito monga adokotala adanenera, nthawi zambiri pambuyo p kulowetsedwa. Kutalika kwa mankhwala ndi miyezi 1-4. Malangizo ogwiritsira ntchito Thiogamma akuti mankhwalawa amatha kumwa mosasamala kanthu ndi chakudya, koma ndi chakudya, njira yolembera imachepa, monga tafotokozera pamwambapa.

Chifukwa chake, kulumikizana ndi adokotala ndikofunikira pankhaniyi.

Kukonzekera ndi makonzedwe a kulowetsedwa njira

Kukonzekera yankho la Thiogamma pakukonzekera kwa mtsempha wa magazi, muyezo umodzi wa 20 mg (wofanana ndi 600 mg wa thioctic acid) wosakanikirana ndi 50-250 ml ya 0,9% sodium chloride solution. Imayendetsedwa ngati kulowetsedwa kwakanthawi kwa mphindi 20-30. Amapangidwa kuchokera ku mabotolo apadera omwe amaikidwa m'miyala yotetezedwa yopepuka yokhazikika ndi mankhwalawo (ndi yakuda bii ndipo imapangidwa ndi polyethylene yapadera).

Ngati infusions amapangidwa kuchokera ku miphika 50 ml, ndiye kuti njirayi imawoneka mwachindunji kuchokera m'botolo momwe yankho limapezekera. Iyenera kuyikidwanso m'malo ena otetemera opangidwa ndi polyethylene yakuda.

Zotsatira zoyipa

Zotsatira zoyipa mutatha kugwiritsa ntchito mankhwalawa zilipo. Pali ena omwe amadzichitira okha ndipo amatenga njira iliyonse kuti athetse

• Matumbo am'mimba: kutentha kwa mtima, kusanza, nseru - kutanthauza, dyspepsia,
• CNS: diplopia, kukomoka, komanso mothandizidwa mwachangu ndi mankhwala osokoneza bongo - kukhathamira, kumva kuwawa m'mutu,
• Hematopoietic system: hemorrhages zotupa pa mucous nembanemba, hemorrhagic zotupa, thrombocytopenia ndi thrombophlebitis,
• Njira yothandizira: ndi makonzedwe ofulumira - kupuma movuta.

Koma pali nyengo zina momwe thandizo lalikulu lingafunikire. Mwachitsanzo, wodwala amatha kukhala ndi hypoglycemia chifukwa cha kuchuluka kwa shuga, komanso matupi awo sagwirizana ndi anaphylactic.

Palibe zotsutsana zambiri za Thiogamma pamapiritsi kapena yankho. Kwenikweni, awa ndi mawonekedwe a thupi lanyama mu thupi nyengo zina za moyo:

• Kuchepetsa
• Mimba
• Zaka za ana
• Hypersensitivity.

Kugwiritsa ntchito kwa mankhwala a Tiogamma sikuthekanso kwa anthu omwe akudwala:

• Kuchokera lactate cidosis (ndipo ngakhale palibe, koma nkosavuta kuyambitsa),
• Aphwanya kwambiri chiwindi ndi impso, amene amachotsa ndikuchotsa mankhwalawo.
• Myocardial infarction, yomwe ili pachimake pachimake (zovuta zoyipa zimatha kuchitika chifukwa cha kufooka kwa thupi),
• Kulephera kwamtima kapena kupuma,
• Pa uchidakwa wambiri,
• Kuthetsa madzi m'thupi
• Zosokoneza pachimake pakufalikira kwa magazi m'dera laubongo (chifukwa cha chiwopsezo cha zotsatira zoyipa mwanjira yakukakamiza kwa intracranial).

Pankhani ya ubwana, ndikofunikira kufotokozera kuti palibe zotsutsana mwapadera, sipanakhalepo kafukufuku pa gulu ili la anthu.

Thiogammasi kumaso

Modabwitsa, koma chithandizo chovuta kwambiri ngati thiogamma cha nkhope, malinga ndi malingaliro a cosmetologists, chitha kugwiritsidwanso ntchito. Malinga ndi iwo, iyi ndi njira yabwino kwambiri yothana ndi khwinya yomwe ingakuthandizeni kuthanso.

Alpho-lipolic acid imathandizira kuchepa kukalamba, kuthetsa makwinya, kupangitsanso khungu, kuthetsa kutupa, kuchepetsa pores ndi zina zotero.

Thiogamma ya nkhope imagwiritsidwa ntchito ngati mitundu ya ma dontho, kuweruza ndi kuwunika kwamakasitomala, ndi kunja. Njira yophweka ndikugwiritsa ntchito pakhungu ndi pediti ya thonje. Maphunzirowa ndi masiku 10, ndipo njirayi imachitika tsiku ndi tsiku.

Wina akuti achite njirayi kawiri patsiku, koma mankhwalawa sanaperekedwe, chifukwa chake ndizosatheka kulosera momwe thupi liyanenera. Mwambiri, thiogamma ya nkhope idalandira ndemanga zabwino. Koma panali ogwiritsa ntchito ma netiweki omwe ankanena kuti nthawi zambiri amakumana ndi zovuta zoyipa - makamaka urticaria komanso ngakhale anaphylactic. Chifukwa chake, chipangizocho sichikulimbikitsidwa pazolinga zotere.

Mankhwala osokoneza bongo. Thioctic (α-lipoic) acid, mankhwala am'mbuyomu antioxidant (amamanga ma radicals aulere), amapanga thupi ndi oxidative decarboxylation ya alpha-keto acid. Monga coenzyme ya mitochondrial multenzyme complexes, imakhudzidwa ndi oxidative decarboxylation ya pyruvic acid ndi alpha-keto acid. Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera zomwe glycogen imayambira m'chiwindi, komanso kuthana ndi insulin.

Amatenga nawo gawo la lipid ndi carbohydrate metabolism, imakhudzanso cholesterol metabolism, imayendetsa ntchito ya chiwindi, imatha kusintha poizoni ndi mchere wambiri ndi zakumwa zina zoledzeretsa. Ili ndi hepatoprotective, hypolipidemic, hypocholesterolemic ndi hypoglycemic. Amakweza ma neuroni a trophic.

Mu matenda a shuga a shuga, thioctic acid imayenda bwino m'magazi am'magazi, kumawonjezera kuchuluka kwa glutathione kukhala phindu lanyama, zomwe zimapangitsa kusintha mu magwiridwe antchito a zotupa zamitsempha yamagazi mu diabetesic polyneuropathy.

Pambuyo pakamwa, thioctic acid imathamanga ndipo imatsala pang'ono kulowa m'mimba. Mukamamwa ndi chakudya, mayamwidwe amachepetsa. Nthawi yofika C max (4 μg / ml) ili pafupifupi mphindi 30. Bioavailability - 30-60% chifukwa cha zotsatira za "gawo loyamba" kudzera pachiwindi.

Iwo zimapukusidwa mu chiwindi ndi mbali unyolo wa oxidation ndi conjugation.

Thioctic acid ndi metabolites ake amuchotseredwa ndi impso (80-90%), pang'ono - osasinthika. T 1/2 ndi 25 min.

Gawani mkati mwa 600 mg (1 tabu.) 1 nthawi / tsiku.

Mapiritsi amatengedwa pamimba yopanda kanthu, popanda kutafuna, ndimadzi pang'ono.

Kutalika kwa chithandizo ndi masiku 30-60, malingana ndi kuopsa kwa matendawa. Kubwereza kwa njira ya mankhwala katatu pachaka.

Zomwe zimachitika pakakhala zovuta zimaperekedwa molingana ndi gulu la WHO:

Zotsatira za pharmacological

Thioctic acid (alpha lipoic acid) - mankhwala am'mbuyomu antioxidant (omanga ma free radicals), amapanga thupi ndi oxidative decarboxylation wa alpha ketoxylate. Monga coenzyme ya mitochondrial multenzyme complexes, imakhudzidwa ndi oxidative decarboxylation ya pyruvic acid ndi alpha-keto acid.

Zimathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikuwonjezera glycogen m'chiwindi, komanso kuthana ndi insulin. Chikhalidwe cha zamankhwala osokoneza bongo chili pafupi ndi mavitamini a B.

Amatenga nawo kayendedwe ka lipid ndi carbohydrate metabolism, imalimbikitsa kagayidwe ka cholesterol, imayendetsa ntchito ya chiwindi. Ali ndi hepatoprotective, hypolipidemic, hypocholesterolemic, hypoglycemic effect. Amakweza ma neuroni a trophic.

Kugwiritsa ntchito mchere wa trometamol wa thioctic acid mu njira za iv (chifukwa chosalowerera m'ndale) kungachepetse zovuta zazomwe zimachitika.

Zotsatira zoyipa

Thupi lawo siligwirizana (urticaria, pruritus, anaphylactic shock). Khansa ya pakhungu ndi kutentha kwa mtima (mukamamwa pakamwa, nthawi zambiri mukamagwiritsa ntchito mchere wa trometamol).

Mothandizidwa ndi mtsempha wa magazi - zotupa mu zotupa za mucous, khungu, thrombocytopathy, hemorrhagic rash (purpura), thrombophlebitis, kuchuluka kwa kuthamanga kwa magazi (kuthamanga mwachangu), kupuma movutikira, hypoglycemia (chifukwa cha kukoka kwa glucose), kupsinjika, diplopia, intracranial matenda oopsa

Thiogamma kapena Berlition?

Wopanga analog amalembetsedwa ku Germany, chinthu chogula chimagulidwa ku China. Pali malingaliro olakwika akuti Berlition ndi yopindulitsa kwambiri pazachuma, koma izi sizowona.

Ziphuphu zakumaso

Njira yotulutsira ndi ma piritsi ndi mapiritsi a 300 mg, kuchuluka kwa mapiritsi omwe ali phukusili ndizochepa kwambiri, zomwe zikutanthauza kuti muyenera kugwiritsa ntchito mlingo wambiri kuti mupeze alpha lipoic acid tsiku lililonse. Zotsatira zake, mtengo wa maphunzirowo umakwera.

Thiogamm kapena Oktolipen?

Analogue yopanga Russian pamtengo wokongola wa ma CD. Koma powerenga mtengo wa maphunzirowa, zimawonekera kuti mtengo wa chithandizo uli pamlingo wazokwera mtengo kwambiri.

Mulingo wa Oktolipen ndi wocheperako, popeza ali ndi ziwonetsero ziwiri zokha zolembetsera - matenda ashuga komanso mowa.

Mwa michere ya biochemical yofanana ndi mavitamini a gulu B.

Kutulutsa mawonekedwe ndi kapangidwe kake

• Njira yothetsera kulowetsedwa: wowoneka bwino, wachikaso wowoneka wachikasu kapena wachikasu (50 ml mu botolo lagalasi lakuda, mabotolo 1 kapena 10 osungidwa pakatoni).
• lingalirani njira yothetsera kulowetsedwa: yankho lomveka bwino la chikasu chobiriwira (20 ml mkati mwa galasi lamdima wakuda, ma ampoules 5 mu thireyi, 1, 2 kapena 4 pallet pamakatoni),
• mapiritsi okhala ndi mbali: oblong, otukutira mbali zonse ziwiri, opepuka wachikaso ndi mitundu yoyera ndi yachikaso yamphamvu yosiyanasiyana, ndi zoopsa kumbali zonse ziwiri, maziko achikasu akuwoneka pamtanda (ma PC 10 mu chithuza, 3, 6 kapena matuza 10 mu bokosi la makatoni).

The yogwira ndi thioctic acid:

• 1 ml ya yankho - 12 mg (600 mg mu botolo limodzi),
• 1 ml yokhazikika - 30 mg (600 mg mu 1 ampoule),
• Piritsi limodzi - 600 mg.

• yankho: macrogol 300, meglumine, madzi a jekeseni,
• lingalira: macrogol 300, meglumine, madzi a jekeseni,
• mapiritsi: colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, simethicone (dimethicone ndi colloidal silicon dioxide mu chiŵerengero cha 94: 6), lactose monohydrate, talc, magnesium stearate, hypromellose, kaphatikizidwe ka sodium.

Malangizo apadera

Pa chithandizo, ndikofunikira kupewa mosamalitsa Mowa.

Odwala omwe ali ndi matenda a shuga, makamaka kumayambiriro kwa chithandizo, kuyang'anira shuga wamagazi ndikofunikira.

Mankhwala ndi ochititsa chidwi, choncho, ma ampoules ayenera kuchotsedwa pokhapokha atangogwiritsa ntchito.

Kuchita

Kuchepetsa mphamvu ya cisplatin.

Imawonjezera zotsatira za insulin ndi mankhwala amkamwa a hypoglycemic.

Zosagwirizana ndi zosakaniza za ringer ndi dextrose, zophatikizira (kuphatikiza njira zawo) zomwe zimayenderana ndi kusakanikirana ndi magulu a SH, ethanol.

Ethanol ndi metabolites ake amawonjezera chiwopsezo cha mavuto.

Mankhwala

Zomwe zimagwiritsa ntchito mankhwalawa ndi thioctic (alpha-lipoic) acid. Ndi ma antioxidant amkati omwe amamangirira zopitilira muyeso. Thioctic acid imapangidwa m'thupi nthawi ya oxidative decarboxylation ya alpha-keto acid. Ndi coenzyme ya maenzenzime ambiri mu mitochondria ndipo amaphatikizidwa ndi oxidative decarboxylation ya alpha-keto acid ndi pyruvic acid.

Alpha-lipoic acid imathandizira kuchepetsa shuga m'magazi, kuonjezera kuchuluka kwa glycogen m'chiwindi ndikugonjetsa insulin kukana. Mwa makina ochitira, ili pafupi ndi mavitamini a gulu B.

Thioctic acid amawongolera chakudya komanso lipid metabolism, imakhudza ntchito ya chiwindi komanso imathandizira kagayidwe ka cholesterol. Ili ndi hypolipidemic, hypoglycemic, hepatoprotective ndi hypocholesterolemic kwenikweni. Chimalimbikitsa thanzi la neurons.

Mukamagwiritsa ntchito meglumine mchere wa alpha-lipoic acid (osatenga nawo mbali) pazomwe mungagwiritsire ntchito makonzedwe amkati, zovuta zoyipa zimatha kuchepetsedwa.

Njira yothetsera kulowetsedwa ndikuyang'anitsitsa pakukonzekera njira yothetsera kulowetsedwa

Njira yothetsera vutoli, kuphatikizapo yokonzedwera kuchokera kumagawo, imayendetsedwa kudzera m'mitsetse.

Mlingo wa tsiku ndi tsiku wa Thiogamma ndi 600 mg (1 botolo la yankho kapena 1 ampoule of concentrate).

Mankhwalawa amatumizidwa kwa mphindi 30 (pamlingo pafupifupi 1.7 ml pa mphindi).

Kukonzekera kwa yankho kuchokera mwakuya: zomwe zili 1 ampoule zimasakanizidwa ndi 50-250 ml ya 0,9% sodium kolorayidi. Mukamaliza kukonzekera, yankho lake liyenera kuyimbidwa nthawi yomweyo ndi nkhani yopanda magetsi. Sungani maola opitilira 6.

Mukamagwiritsa ntchito njira yomwe inakonzedwa kale, ndikofunikira kuchotsa botolo kuchokera pazonyamula ma katoni ndikuwaphimba mwachangu ndi mlandu woteteza. Kulowetsedwa kuchitike mwachindunji vial.

Kutalika kwa chithandizo ndi masabata 2-2. Ngati ndi kotheka, pitilizani mankhwala, wodwalayo amamuika piritsi la mankhwalawo.

Malangizo ndi kukhazikika

• kuchokera ku endocrine system: kuchepa kwa kuchuluka kwa shuga m'magazi (kusokonezeka kowoneka, thukuta kwambiri, chizungulire, kupweteka kwa mutu),
• mbali yamanjenje yamkati: kuphwanya kapena kusintha kukoma, kupweteka, khunyu,
• Kuchokera kwa hemopoietic dongosolo: hemorrhagic zidzolo (purpura), thrombocytopenia, thrombophlebitis, kuloza zotupa pakhungu ndi mucous nembanemba,
• pakhungu ndi minyewa yolimba: chikanga, kuyabwa, zotupa,
• mbali ya gawo la masomphenyawo: diplopia,
• thupi lawo siligwirizana: urticaria, zokhudza zonse zimachitika (kusapeza bwino, nseru, kuyabwa) mpaka chitukuko cha anaphylactic mantha,
• zimachitika mdera: Hyperemia, mkwiyo, kutupa,
• ena: ngati mankhwala akupangidwira msanga - kupuma movutikira, kuchuluka kwa nkhawa (pamakhala kumva kuwawa m'mutu).

Mapiritsi okhala ndi mbali

Mapiritsi ayenera kumwedwa pakamwa popanda kanthu: kumeza lonse ndikumwa madzi ambiri.

Kutalika kwa chithandizo, kutengera kuuma kwa matendawa, ndi masiku 30-60.

Ngati ndi kotheka, katatu pachaka, mutha kuchititsa maphunziro obwereza.

Zotsatira zoyipa

Malangizo ndi kukhazikika

• kuchokera ku endocrine system: kuchepa kwa kuchuluka kwa shuga m'magazi (kusokonezeka kowoneka, thukuta kwambiri, chizungulire, kupweteka kwa mutu),
• mbali yamanjenje yamkati: kuphwanya kapena kusintha kukoma, kupweteka, khunyu,
• Kuchokera kwa hemopoietic dongosolo: hemorrhagic zidzolo (purpura), thrombocytopenia, thrombophlebitis, kuloza zotupa pakhungu ndi mucous nembanemba,
• pakhungu ndi minyewa yolimba: chikanga, kuyabwa, zotupa,
• mbali ya gawo la masomphenyawo: diplopia,
• thupi lawo siligwirizana: urticaria, zokhudza zonse zimachitika (kusapeza bwino, nseru, kuyabwa) mpaka chitukuko cha anaphylactic mantha,
• zimachitika mdera: Hyperemia, mkwiyo, kutupa,
• ena: ngati mankhwala akupangidwira msanga - kupuma movutikira, kuchuluka kwa nkhawa (pamakhala kumva kuwawa m'mutu).

Mapiritsi okhala ndi mbali

Thiogamm nthawi zambiri limalekeredwa. Nthawi zambiri, kuphatikiza pazofanana, zotsatira zotsatirazi zimachitika:

• thupi lawo siligwirizana: urticaria, zotupa pakhungu, kuyabwa, zokhudza zonse zimachitika mpaka anaphylactic mantha,
• Kuchokera kumimba: kupweteka kwam'mimba, nseru, m'mimba, kusanza,
• kuchokera ku endocrine system: kuchepa kwa kuchuluka kwa shuga m'magazi (kusokonezeka kowoneka, thukuta lakukula, chizungulire, kupweteka mutu).

Kuyanjana kwa mankhwala osokoneza bongo

• Mowa ndi metabolites: mphamvu ya thioctic acid imafooka,
• cisplatin: mphamvu yake imachepa
• glucocorticosteroids: awo odana ndi kutupa amakhala
• insulin, mankhwala a m'kamwa a hypoglycemic: zotsatira zake zimakhala bwino.

Thioctic acid imamanga zitsulo (chitsulo, magnesium), chifukwa chake, ngati kuli koyenera, kugwiritsa ntchito nthawi yomweyo kukonzekera komwe kumachitika kuyenera kuchitika pakadutsa pafupifupi maola 2 pakati pamiyeso.

Thioctic acid amakumana ndi mamolekyulu a shuga, mwachitsanzo, ndi yankho la levulose (fructose), chifukwa chomwe mapangidwe osakwanira amapangidwa.

Mwanjira yothetsera kulowetsedwa, Thiogamm sangagwirizane ndi mayankho omwe amachitika chifukwa chosagwirizana ndi magulu a SH, yankho la Ringer ndi dextrose solution.

Mankhwala otsatirawa ndi fanizo za Thiogamm: Thioctacid BV, Lipoic acid, Tiolepta, Berlition 300, Thioctacid 600T.

Migwirizano ndi magwiritsidwe akusungidwa

Pewani patali ndi ana, mutetezedwe ndi kuwala, kutentha mpaka 25 ° C.

Moyo wa alumali ndi zaka 5.

Tsambali limapereka mndandanda wa mayendedwe onse a Tiogamm pophatikizika ndikuwonetsa kuti angagwiritse ntchito. Mndandanda wama analogi otsika mtengo, mutha kuyerekezeranso mitengo muma pharmacies.

• Analogue yotsika mtengo kwambiri ya Tiogamm:
• Analogue otchuka kwambiri a Tiogamm:
• Gulu la ATX: Thioctic acid
• Zosakaniza / yogwira: thioctic acid

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa komanso momwe mungagwiritsire ntchito

Kuti tipeze mndandanda wamtengo wotsika mtengo wa mankhwala okwera mtengo, timagwiritsa ntchito mitengo yomwe imatipatsa mankhwala opitilira 10,000 mu Russia yonse. Dongosolo la mankhwala osokoneza bongo ndi fanizo lawo limasinthidwa tsiku ndi tsiku, chifukwa chake zambiri zomwe zimaperekedwa patsamba lathu zimakhazikika pofika lero. Ngati simunapeze analogue yosangalatsa kwa inu, chonde gwiritsani ntchito kusaka pamwambapa ndikusankheni mankhwala osangalatsa kuchokera pamndandanda. Patsamba lililonse la iwo mupeza zosankha zonse za mankhwala omwe mungafune, komanso mitengo ndi ma adilesi omwe amapezeka.

Malangizo a Tiogamm

MALANGIZO
pa kugwiritsa ntchito mankhwalawa
Tiogamma

Zotsatira za pharmacological
Pulogalamu yogwira Thiogamm (Thiogamma-Turbo) ndi asidi wa thioctic (alpha-lipoic). Thioctic acid imapangidwa m'thupi ndipo imagwira ntchito ngati coenzyme yopanga mphamvu ya alpha-keto acid ndi oxidative decarboxylation. Thioctic acid imayambitsa kutsika kwa glucose mu seramu yamagazi, imathandizira kuti glycogen ichulukane mu hepatocytes. Mavuto a metabolism kapena kusowa kwa thioctic acid amawonedwa ndikuchulukitsidwa kwambiri kwa metabolites ena mthupi (mwachitsanzo, matupi a ketone), komanso ngati atamwa. Izi zimabweretsa zosokoneza mu unyolo wa aerobic glycolysis. Thioctic acid ilipo mthupi mu mawonekedwe a mitundu iwiri: yochepetsedwa ndikuwonjezeredwa. Mitundu yonseyi ndi yogwira ntchito mwakuthupi, imapereka antioxidant komanso anti-sumu.
Thioctic acid amawongolera kagayidwe kazakudya ndi mafuta, zimakhudza kagayidwe ka cholesterol, imakhala ndi hepatoprotective, ikukhudza ntchito ya chiwindi. Zothandiza pa obwezeretsanso njira mu minofu ndi ziwalo. Mankhwala okhala ndi thioctic acid ndi ofanana ndi mavitamini a B. Pamugawo woyamba wa chiwindi, thioctic acid amasintha kwambiri. Mwa kupezeka kwa mankhwalawa, kusinthasintha kwakukulu kumawonedwa.
Ikagwiritsidwa ntchito mkati, imathamanga ndipo imatsala pang'ono kulowa m'mimba. Metabolism imapitilira ndi kukhathamiritsa kwa mbali ya thioctic acid ndi kuphatikizika kwake. Kutha kwa theka-moyo wa Tiogamm (Tiogamm-Turbo) kuyambira 10 mpaka 20 mphindi. Amachotsedwa mu mkodzo, ndi metabolites of thioctic acid predominating.

Zizindikiro zogwiritsidwa ntchito
Ndi diabetesic neuropathy kusintha minofu kumva.

Njira yogwiritsira ntchito
Thiogamm-Turbo, Thiogamm wa kasamalidwe ka makolo
Thiogamm-Turbo (Thiogamma) cholinga chake ndi kuwongolera makolo mwa kulowetserera mtsempha wamagetsi. Kwa akuluakulu, mlingo wa 600 mg (zomwe zili mu 1 vial kapena 1 ampoule) zimagwiritsidwa ntchito kamodzi patsiku. The kulowetsedwa ikuchitika pang'onopang'ono, kwa mphindi 20-30. Njira yochizira matendawa ndi pafupifupi milungu iwiri kapena inayi. M'tsogolomu, kugwiritsa ntchito kwa Tiogamma m'mapiritsi kumalimbikitsidwa. Makulidwe a Pareogeral a Thiogamma-Turbo kapena Thiogamm kulowetsedwa amalembedwa chifukwa cha zovuta zakumverera zomwe zimagwirizanitsidwa ndi matenda ashuga a polyneuropathy.

Malamulo okhudzana ndi makolo pa Thiogamm-Turbo (Thiogamm)
Zomwe zili m'botolo 1 la Thiogamma-Turbo kapena 1 ampoule wa Thiogamma (600 mg wa mankhwalawa) zimasungunuka mu 50-250 ml ya yankho la 0.9% sodium chloride. Mlingo wa kulowetsedwa kwa mtsempha - osapitirira 50 mg ya thioctic acid mu miniti imodzi - izi zikufanana ndi 1.7 ml ya yankho la Tiogamma-Turbo (Tiogamm). Kukonzekera kuchepetsedwa kuyenera kugwiritsidwa ntchito mukangosakaniza ndi zosungunulira. Pa kulowetsedwa, njira yothetsera vutoli iyenera kutetezedwa ndikuwala ndi chinthu chapadera choteteza kuwala.

Tiogamma
Mapiritsiwo adapangira kuti azigwiritsa ntchito mkati. Ndi bwino kupereka mankhwala a 600 mg kamodzi pa tsiku. Piritsi liyenera kumezedwa lonse, litenge popanda chakudya, kutsukidwa ndi madzi okwanira. Kutalika kwa mankhwalawa kwa mapiritsi kuyambira 1 mpaka miyezi 4.

Zotsatira zoyipa
Central mantha system: nthawi zina, mutagwiritsa ntchito mankhwalawa kulowetsedwa, kupindika kwamisempha kumatheka.
Zokhudza ziwalo: kuphwanya tanthauzo la kukoma, diplopia.
Hematopoietic dongosolo: purpura (hemorrhagic zidzolo), thrombophlebitis.
Hypersensitivity reaction: systemic zochita zimatha kuyambitsa anaphylactic, eczema kapena urticaria pamalo a jekeseni.
Dongosolo logaya (la mapiritsi a Tiogamm): mawonetseredwe a dyspeptic.
Ena: ngati Tiogamma-Turbo (kapena Tiogamma wa makina oyang'anira makolo) akaperekedwera mwachangu, kupuma kwamphamvu komanso kumverera kovutikira m'mutu ndikotheka - izi zimayima pambuyo pakuchepa kwa kulowetsedwa. Chothekanso: hypoglycemia, kutentha kwa moto, chizungulire, thukuta, kupweteka mumtima, kutsika magazi, kutsukidwa, kuwona kwamaso, mutu, kusanza, tachycardia.

Contraindication
Mkhalidwe wodwala womwe umayambitsa kukhazikika kwa lactic acidosis (kwa Thiogamm-Turbo kapena Thiogamm kwa utsogoleri waboma),
zaka za ana
mimba ndi mkaka wa m`mawere
thupi lawo siligwirizana ndi thioctic acid kapena zinthu zina za Thiogamm (Thiogamm-Turbo),
chachikulu kwa chiwindi kapena matenda aimpso,
pachimake pachimake infarction,
njira yofupika ya kupuma kapena mtima
kusowa kwamadzi
uchidakwa wambiri,
pachimake cerebrovascular ngozi.

Mimba
Pa nthawi yoyembekezera kapena yoyamwitsa, kugwiritsa ntchito kwa Thiogamma ndi Thiogamm-Turbo sikulimbikitsidwa, popeza palibe chidziwitso chokwanira chachipatala chodziwitsa mankhwala.

Kuyanjana kwa mankhwala osokoneza bongo
Kuchita bwino kwa mankhwala a hypoglycemic ndi insulin kumakulitsidwa limodzi ndi Thiogamma (Thiogamma-Turbo). Njira ya Thiogamm-Turbo kapena Thiogamm sigwirizana ndi zosungunulira zomwe zimakhala ndi mamolekyu a glucose, chifukwa thioctic acid imapangika m'magulu a shuga. Pakuyesera kwa vitro, thioctic acid imachitika ndi zitsulo zazitsulo. Mwachitsanzo, pawiri wokhala ndi chisplantine, magnesium, ndi chitsulo amatha kuchepetsa zomwe zimachitika pakuphatikizidwa ndi thioctic acid. Ma sol sol omwe ali ndi zinthu zomwe zimamangilira kupopera mankhwala kapena magulu a SH sagwiritsidwa ntchito kuti athetse njira ya Thiogamma-Turbo (Thiogamma) (mwachitsanzo, yankho la Ringer).

Bongo
Ndi mankhwala osokoneza bongo a Tiogamm (Tiogamm-Turbo), kupweteka mutu, kusanza, ndi mseru ndizotheka. Mankhwalawa ndi chizindikiro.

Kutulutsa Fomu
Tiogamm Turbo
Yankho la kulowetsedwa kwa maberekedwe mu mamililita 50 (1.2% thioctic acid). Mu phukusi - 1, mabotolo 10.Milandu yapadera yopanda magetsi.

Mapiritsi a Tiogamm
Mapiritsi a 600 mg omwe ali ndi ntchito mkati. Mu phukusi la 30, mapiritsi 60.

Thiogamma yankho la kulowetsedwa
Njira yothetsera makulidwe a makolo m'magawo 20 ml (3% thioctic acid). Mu phukusi - 5 ampoules.

Malo osungira
Pamalo omwe amatetezedwa ku kuwala, kutentha kwa 15 mpaka 30 digiri Celsius. Njira yothetsera kulowetsedwa mwaubongo siyikusungidwa. Ampoules ndi Mbale ziyenera kungokhala pazoyikapo zoyambirira.

Kupanga
Tiogamm Turbo
Zogwira ntchito (50 ml): thioctic acid 600 mg.

50 ml ya njira ya kulowetsa kwa Tiogamma-Turbo ili ndi mchere wa meglumine wa alpha-lipoic acid wambiri 1167.7 mg, womwe umafanana ndi 600 mg wa thioctic acid.
Tiogamma
Zothandiza (piritsi limodzi): thioctic acid 600 mg.
Zowonjezera: colloidal silicon dioxide, cellcrystalline cellulose, talc, lactose, methylhydroxypropyl cellulose.
Tiogamma
Zogwira ntchito (20 ml): thioctic acid 600 mg.
Zowonjezera: madzi a jakisoni, macrogol 300.
20 ml ya njira ya kulowetsa kwa Tiogamma imakhala ndi mchere wa meglumine wa alpha-lipoic acid wambiri 1167.7 mg, womwe umafanana ndi 600 mg wa thioctic acid.

Gulu la mankhwala
Mahormone, analogues awo ndi antihormonal mankhwala
Mankhwala okhala ndi pancreatic mahomoni ndi mankhwala opangira hypoglycemic
Synthetic hypoglycemic wothandizira

Zogwira ntchito : Thioctic acid

Zosankha
Pamabotolo okhala ndi a Thiogamm-Turbo osungunuka, milandu yapadera yoteteza kuunika imayikidwa, yomwe imaphatikizidwa ndi mankhwalawa. Njira ya Thiogamm imatetezedwa ndi zida zoteteza. Mankhwalawa odwala, kuchuluka kwa shuga wa seramu kuyenera kuyesedwa pafupipafupi, malinga ndi momwe mlingo wa insulin ndi mankhwala a hypoglycemic ayenera kusinthidwira kuti mupewe hypoglycemia. Ntchito zochizira thioctic acid zimachepetsedwa kwambiri ndi mowa (ethanol). Palibe chenjezo lina lofunikira.

Chidziwitso chonse chimaperekedwa pofuna kudziwa zambiri osati chifukwa chodzipangira nokha kapena kusintha mankhwala.

The fanizo la thiogamm ya mankhwala imaperekedwa, malinga ndi tanthauzo lachipatala lomwe limatchedwa "ma syonyms" - mankhwala osinthika omwe ali ndi chinthu chimodzi kapena zingapo zomwe zimagwira ntchito mothandizidwa ndi thupi. Mukamasankha mawu ofananitsa, osangoganizira mtengo wawo, komanso dziko lakapangidwe ndi mbiri ya wopanga.

Zotsatira za pharmacological

Chofunikira chachikulu pakupanga mankhwala a Tiogamm, mosasamala mawonekedwe a kumasulidwa thioctickapena alpha lipoic acid (mayina awiri a chinthu chomwecho cha biological yogwira). Ichi ndi gawo lachilengedwe la kagayidwe, ndiye kuti acid zambiri zimapangidwa mthupi ndipo zimachitika coenzyme wa mitochondrial maofesi mphamvu kagayidwe ka pyruvic acid ndi alpha-keto acid munjira ya oxidative decarboxylation. Thioctic acid imakhalanso yamkati, popeza imatha kumanga ma radicals aulere komanso kuteteza maselo kuti asawonongeke motere.

Udindo wa gawo la mankhwala ndiwofunikanso chakudya kagayidwe kachakudya. Zimathandizira kuchepetsa kufalikira kwa glucose momasuka mu seramu yamagazi ndi kuchuluka kwa glycogen m'maselo a chiwindi. Chifukwa cha nyumbayi, thioctic acid imachepetsa maselo, ndiko kuti, kuyankha kwakuthupi kwa hormone iyi kumagwira ntchito kwambiri.

Analowa Malangizo a lipid metabolism. Mphamvu ya yogwira pophatira kagayidwe kachakudya monga hypocholesterolemic wothandizila imadziwika kwambiri - asidi amachepetsa kufalikira kwa lipids yotsika kwambiri komanso yotsika kwambiri komanso kuchuluka kwa lipids okwera kwambiri mu seramu kumawonjezeka). Ndiye kuti, thioctic acid ali ndi zina antiatherogenic katundu ndipo amatsuka bedi yaying'ono- ndi macrocirculatory yamafuta ochulukirapo.

Zotsatira zakusintha Kukonzekera kwamankhwala kumawonekeranso ngati poyizoni ndi mchere wambiri wazitsulo ndi mitundu ina. Kuchita izi kumachitika chifukwa cha kutseguka kwa njira mu chiwindi, chifukwa chake ntchito yake imayenda bwino. Komabe, asidi wa thioctic samathandizira kutopa kwake. hepatoprotective katundu.

Tiyenera kudziwa kuti mankhwala okhala ndi alpha-lipoic acid amagwiritsidwa ntchito mwachangu, chifukwa opangawo amathandizira kuchepetsa mapangidwe omaliza a glycation metabolites ndikuwonjezera zomwe zili muzochitika zachilengedwe. Komanso misempha yama trophic imakhala bwino ndi kutsika kwa magazi kwa endoneural, komwe kumapangitsa kuti chiwonetsero cha matenda ophatikizika amitsempha ndikulepheretsa kukula kwa matenda ashuga (gawo la nosological lomwe limayamba chifukwa cha kuwonongeka kwa mizere ya mitsempha ndi kuchuluka kwa glucose komanso metabolites yake).

Mu mankhwala ake a hepato- ndi neuroprotective, detoxization, antioxidant, hypoglycemic ndi ena ambiri) thioctic acid ndi ofanana mavitaminiGulu B.

Thioctic kapena alpha lipoic acid yatchuka kwambiri mu cosmetologychifukwa cha kutsatira kwa pharmacological khungu la nkhope, zomwe nthawi zambiri zimakhala zovuta kusamalira:

• kunyamuka Hypersensitivity,
• kulimbitsa khungu lanu amachepetsa makwinyakuwapanga kukhala osawoneka ngakhale m'malo ovuta monga ngodya zamaso ndi milomo,
• amachiritsa matenda a (ziphuphu) ndi zipsera, popeza, kulowa mkati mwa zinthu zomwe zimapangidwira, kumapangitsa kuti magwiridwe antchito apangidwe mobwerezabwereza,
• amalimbitsa pores pankhope ndikuyang'anira luso lantchito zotupa za sebaceouspotero kuthetsa mavuto a khungu lamafuta kapena mafuta.
• amachita ngati antioxidant wamphamvu wa amkachokera.

Thiogamma, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Malangizo ogwiritsira ntchito Thiogamm amasiyanasiyana malinga ndi mtundu wa mankhwala omwe mumagwiritsidwa ntchito.

Mapiritsi a 600 mg Kugwiritsa pakamwa kamodzi patsiku. Osamawataya, popeza chipolopolo chitha kuwonongeka, tikulimbikitsidwa kuti mumwe ndi madzi ochepa. Kutalika kwa maphunzirowa kumatchulidwa ndi dokotala wokhazikika, chifukwa zimatengera kuchuluka kwa matendawo. Nthawi zambiri mapiritsi amatengedwa kuchokera masiku 30 mpaka 60. Kubwereza maphunziro othandizira olimbitsa thupi ndizotheka katatu pachaka.

Tiogamm Turbo ntchito kwa makolo makonzedwe a mtsempha wa magazi kukapanda kuleka kulowetsedwa. Mlingo wa tsiku ndi tsiku ndi 600 mg 1 nthawi patsiku - wowerengeka pazomwe zili m'botolo imodzi kapena wokwanira. Kumayambiriro kumachitika pang'onopang'ono, kopitilira mphindi 20-30, kuti mupewe zotsatira zoyipa kuchokera pakulowetsedwa kwa mankhwala. Njira ya mankhwala a mankhwalawa imachokera ku milungu iwiri mpaka inayi (kufupikitsika kwa nthawi yodziwikiratu chithandizo kumachitika chifukwa cha kuchuluka kwa plasma ndende pambuyo pa utsogoleri waudokotala).

Gwiritsani ntchito kukonzekera kulowetsedwa kwamitsempha Gwiritsani ntchito motere: zomwe zili mu 1 ampoule (malinga ndi chophatikizira chachikulu - 600 mg wa thioctic acid) zimaphatikizidwa ndi 50-250 isotonic (0,9%) yankho la sodium chloride. Atangomaliza kupangira mankhwalawa, botolo limakutidwa ndi vuto loteteza (mosalephera, pamakhala piritsi limodzi pakukonzekera mankhwala). Nthawi yomweyo, yankho limaperekedwa ndi kulowetsedwa kwa kulowetsedwa kwa mphindi 20-30. Nthawi yayikulu yosungirako yothetsera Tiogamm yotsala sinaposa maola 6.

Thiogamma imagwiritsidwa ntchito posamalira khungu. Kuti muchite izi, gwiritsani ntchito mankhwala mawonekedwe a otsikira Mbale (ma ampoules omwe amakhala ndi chidwi chokhazikitsira kulowetsedwa kwa intravenous sioyenera monga chinthu chodzikongoletsa, chifukwa amatha kuyambitsa zovuta chifukwa chifukwa cha kuchuluka kwa gawo lomwe limagwira. Zomwe zili m'botolo limodzi zimayikidwa pakhungu loyera pakhungu kawiri pa tsiku - m'mawa ndi madzulo. Pamaso pa kunyengedwa kotereku, tikulimbikitsidwa kusamba ndi madzi ofunda, a sopo kuti muyeretse pachipata cha ma pores kuti mulowetse kwambiri thioctic acid.

Zolemba za Thiogamma

Kufanana kwa code ya ATX Level 4:

Mapulogalamu a Thiogma amapanga gulu lalikulu la mankhwala, chifukwa zochizira zomwe zaperekedwa tsopano ndizodziwika kwambiri. Ndiosavuta kugwiritsa ntchito mankhwalawa kupewa matenda amitsempha yayikulu kuposa kuwachiritsa pambuyo pake ndi njira yolephera, ndikuyenda mankhwala osokoneza bongo kwa nthawi yayitali. Chifukwa chake limodzi ndi a Tiogamma amagwiritsidwa ntchito:

Tiogamm: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Thiogamm

Code ya ATX: A16AX01

Zosakaniza: Thioctic acid (Thioctic acid)

Wopanga: Verwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Germany

Sinthani mafotokozedwe ndi chithunzi: 05/02/2018

Thiogamma ndi mankhwala omwe amawongolera metabolidi ya lipid ndi carbohydrate.