Neurontin - malangizo ogwiritsidwa ntchito

Mankhwala ndi amodzi mwa anticonvulsants. Chifukwa chogwiritsa ntchito Neurontin, ndizotheka kuyimitsa kupweteka komwe kunayambika motsutsana ndi maziko a neuropathic pathology.

Kugwiritsa ntchito kwa mankhwala Neurontin akuwonetsedwa:

• Kupweteka kwambiri kwa neuropathic (mankhwalawa akuwonetsedwa kwa anthu azaka zopitilira 18)
• Chithandizo cha mankhwala okomoka pang'ono, mosasamala kanthu kwachiwiri (chokhazikitsidwa kwa ana azaka zitatu zothandizira kupweteka, monotherapy ndiyotheka kuyambira wazaka 12)

Kupanga ndi mafomu omasulira

Mapiritsi a Neurotin ali ndi chigawo chimodzi chogwira ntchito, chomwe ndi gabapentin, kuchuluka kwake mu piritsi imodzi ndi 600 mg ndi 800 mg. Malinga ndi malongosoledwewo mulinso:

• Copovidone
• Stearic Acid Mg
• Talcum ufa
• Phula
• Poloxamer
• Wokoma
• Hydroxypropyl cellulose
• Opadry yoyera.

Makapisozi ali ndi gabapentin mu mlingo wa 100 mg, 300 mg kapena 400 mg. Opezekapo ndi monga:

Makapisozi ndi zoyera (Mlingo 100 mg), chikasu (300 mg mg), komanso imvi-lalanje (mlingo wa 400 mg). Mkati mwa kapisozi kalikonse mumapezeka zinthu zoyera. Makapisozi amaikidwa muchimake cha ma PC 10, pali matuza 5 kapena 10 mkati mwake.

Mapiritsi ozungulira oyera amawaika mu chithuza chamtundu wa ma PC 10., Phukusili lili ndi matuza 2, 5 kapena 10.

Kuchiritsa katundu

Gabapentin amalowetsedwa mwachangu ndipo amalowa mosavuta mu minyewa yaubongo, amalepheretsa kuwoneka kwa matenda opatsirana mwa mitundu ina ya khunyu. Katundu wogwira amadziwika ndi gulu la GABA receptors la GABA ndipo silikuwakhudza mayendedwe a GABA. Ndizofunikira kudziwa kuti chinthu chomwe Neurontin chimagwira sichigwirizana ndi ma receptor amtundu wina wa ma neurotransmitters omwe amapezeka mu ubongo ndipo samakhudza mwachindunji mayendedwe a sodium.

Gabapentin amagwirizanitsidwa ndi njira ya α-2-δ yogwiritsira ntchito njira zama calcium zamagetsi, malinga ndi malipoti ena, izi ndizomwe zimawonetsera chiwonetsero cha anticonvulsant zotsatira ndikuchotsa kupweteka kwa neuropathic.

Pamodzi ndi izi, amachepetsa kufa kwa mitsempha yodalira ma glutamate, amathandizira kuwonjezeka kwa GABA, komwe kumapangitsa kuchepa kumasulidwa kwa ma neurotransmitters iwo eni, omwe akuphatikizidwa ndi gulu la monoamine.

Chizindikiro chachikulu kwambiri cha bioavailability pafupifupi 60%; kutsika kwake kulembedwa ndikuwonjezereka kwa kuchuluka kwa mankhwala. Kuzindikira kwakukulu kwa plasma kumatha kufikira maola 2-3 mutatha kumwa mapiritsi. Kuyanjana kwa gabapentin ndi mapuloteni a plasma ndikosatheka (pafupifupi 3%).

Hafu ya moyo siyinso yopitilira maola 7, ngakhale mutamwa mankhwalawo. Mankhwala amachotsedwa mu mawonekedwe ake oyamba ndikuchita nawo impso.

Neurontin: malangizo onse ogwiritsira ntchito

Mtengo wamapiritsi: kuyambira 1125 mpaka 1898 rubles. Mtengo wa makapisozi: kuchokera ku 902 mpaka 1629 rubles.

Mankhwala tikulimbikitsidwa kumwa onse pakudya kapena pambuyo pake.

Njira ya mankhwala achikulire vuto la neuropathic ululu:

• Tsiku 1 - kugwiritsa ntchito kamodzi mu mankhwala Mlingo wa 300 mg
• 2 tsiku - tikulimbikitsidwa kumwa 300 mg ya mankhwala kawiri pa tsiku
• 3 tsiku - kulandiridwa kwa Neurontin 300 katatu patsiku kukuwonetsedwa, nthawi zina ndizotheka kugwiritsa ntchito mankhwalawa kuyambira chiyambi cha mankhwala
• Kugwiritsa ntchito pambuyo pake - Mlingo wa Neurontin udzadalira momwe achire amathandizira komanso momwe wodwalayo alili, mlingo wake umasinthidwa kapena kuwonjezereka (Mlingo wapamwamba tsiku lililonse wa mankhwala ndi 3,6 g).

Mlingo wa mankhwalawa pa mankhwala ochiritsira pamaso pa anthu akugwirira ntchito zaka zopitilira 12 amasankhidwa malinga ndi chiwembu chomwe tafotokozachi. Popewa kuyambiranso kwa matenda opatsirana, muyenera kumwa mapiritsi kapena mapiritsi okhala ndi maola 12.

Kupereka mankhwala kwa ana a zaka 3 mpaka 12 ndi kukomoka pang'ono:

• Kuwerengera kuchuluka kwa kulemera
• Kuyambira pa tsiku la 1 la mankhwala, kugwiritsa ntchito mankhwalawa katatu ndi nthawi yopitilira maola 12
• Mlingo woyenera wofika tsiku lililonse ndi 10-15 mg pa 1 kg
• M'masiku atatu oyamba, kumwa mankhwala kumawonjezereka
• Mulingo wothandiza wa tsiku lililonse la mankhwalawa: ana osaposa zaka 3-5 ndi 40 mg pa 1 makilogalamu, kuyambira wazaka 5 mpaka 12 - 25-35 mg ya mankhwala pa 1 kg amasonyezedwa.

Ngati aimpso ntchito, tikulimbikitsidwa kuchepetsa mlingo wa Neurontin. Mukasankhidwa kuti mupeze mlingo woyenera, ndikofunikira kuganizira mawonekedwe a creatinine chilolezo.

Mukamaliza kulandira mankhwalawa, muyenera kuwunika momwe dokotala akuwonekera kuti ali bwino.

Contraindication ndi Kusamala

Sitikulimbikitsidwa kugwiritsa ntchito mankhwala omwe ali pa gabapentin a:

• Zaka zaana (mwana ali ndi zaka zosakwana 3)
• Kukhalapo kwa chiwopsezo chochuluka kwa chinthu chachikulu.

Mosamala, chithandizo chikuyenera kuchitika mwa anthu achikulire ndi odwala omwe ali ndi impso.

Panthawi ya makapisozi ndi mapiritsi a Neurontin, chitukuko cha matenda omwe amachokera pakubwera pambuyo pake chinayamba kulembedwa. Ngakhale izi, kutha kwadzidzidzi kwa mankhwalawa mankhwala opha anticonvulsant mwa anthu omwe agwidwa ndi gawo pang'ono kungayambitse mawonekedwe awo.

Makapisozi amaphatikiza lactose, kotero anthu omwe ali ndi vuto lobadwa nawo malabsorption, galactose tsankho, ndi kuchepa kwa lactase sayenera kumwa.

Kuchita mankhwala osokoneza bongo

Mukumwa morphine (mankhwalawa adatengedwa pafupifupi maola awiri ntchito ya Neurontin), kuwonjezereka kwa kuchuluka kwa gabapentin ndi 44% kunalembedwa poyerekeza ndi zomwe zimawonedwa ndi monotherapy ndi Neurontin. Zotsatira zoyipa za morphine pogwiritsa ntchito othandizira a gabapentin sizinasiyane ndi zomwe zinajambulidwa ndi morphine ndi placebo.

Panalibe zovuta zoyipa zamankhwala zochokera ku valproic acid, phenobarbital, carbamazepine, ndi phenytoin.

Mukamamwa ma COC, kuphatikizapo norethindrone kapena ethinyl estradiol, panalibe kusintha kwa pharmacokinetics ya mankhwala aliwonse.

Mankhwalawa othandizira maantacid, kuphatikizapo Al ndi Mg, kukhudzana kwa galapentin palokha kumatheka ndi 20%.

Zotsatira zoyipa ndi bongo

Munthawi ya chithandizo ndi Neurontin, zizindikiro zotsatirazi zitha kulembedwa:

• Kuphwanya kwa mpando
• Chisokonezo
• Kumva pakamwa kuwuma
• Ululu pamimba ndi kumbuyo
• Kutsekemera kwam'mimba
• Mutu waukulu
• Kukula kwa chifuwa ndi chifuwa matenda
• The kupezeka kwa zotumphukira puffness
• Mphuno zam'mimba
• Kusintha kwa thupi
• Kupuma pang'ono
• Zotupa pakhungu
• Pharyngitis, chifuwa
• Kusintha kwa Gait
• Kugona
• Kupezeka kwa Hypersthesia.

Sichiyenera kuonedwa pang'ono:

• Nystagmus
• Chibayo
• Kusokonezeka tulo
• Kutengeka kwa zinthu zina
• Kutentha
• Kukula kwa kutengeka mtima
• Zizindikiro za asthenia, ataxia
• Kukula kwa kuganiza
• Ziphuphu Zikumayenda
• Hyperkinesia
• Amblyopia
• Kukula kwa amnesia
• Diplopia

Mukamamwa mankhwala osokoneza bongo, kukula kwa zizindikiro zotere kumatha kuonekera:

• Kuyankhula zopanda pake
• Chizungulire
• Kugona kwambiri
• Zowonongeka
• Kutsegula m'mimba.

Ndikulimbikitsidwa kuchitapo kanthu omwe cholinga chake ndi kuthetsa zizindikiridwe zomwe zidawonedwa. Mu vuto la impso, kusowa kwa hemodialysis kungasonyezedwe.

Ngati ndi kotheka, dokotala angalimbikitse kusintha kwa Neurinu ndi analogi. Kulandila mapiritsi, makapisozi (mankhwala omwe ali ndi vuto lofananalo) amachitika molingana ndi chiwembu chosankhidwa payekha.

Artesan Pharma

Mtengo kuyambira 352 mpaka 1127 rubles.

Mankhwala omwe amadziwika ndi antiepileptic effect. Ndikulimbikitsidwa kutenga kuti muthane ndi kukoka pang'ono pakati pa ana azaka 12 ndi akulu, ndiwothandiza kupweteka, komwe kumachitika chifukwa cha neuralgia, neuropathy. Chosakaniza chophatikizacho ndi gabapentin. Amapezeka mu mawonekedwe a makapisozi ndi mulingo wa 100 mg, 300 mg ndi 400 mg.

Ubwino:

• Ili ndi tanthauzo lotchedwa analgesic
• Wolekeredwa bwino
• Osapukusidwa mu chiwindi.

Chuma:

• Zitha kupangitsa kukhazikika kwa minyewa yotupa
• Contraindified mu pachimake kapamba.
• Chenjezo liyenera kutengedwa ndi zovuta zamagazi.