Momwe mungagwiritsire ntchito Fenofibrate?

Fenofibrate ndi lipid yotsitsa mankhwalawa yomwe imagwiritsidwa ntchito pochiza hypercholesterolemia ndi hyperlipidemia yosakanikirana. Zotsatira zimakhazikitsidwa ndi kuyambitsa kwa PPARcy receptors. Mankhwalawa nthawi zambiri amatengedwa kamodzi patsiku ndi chakudya. Zotsatira zoyipa zomwe zimakhala ndizotsatira ndi mutu ndi kudzimbidwa. Fenofibrate imatha kupangitsa khungu kusamala ndi dzuwa.

Kupanga ndi mawonekedwe a kumasulidwa

Fenofibrate imapezeka mu mawonekedwe a ufa wamiyira yoyera, womwe umakhala wopanda madzi. Mankhwala amaphatikizidwa m'thupi kuti azichita fenofibric acid.

Pakadali pano (2018), fenofibrate yoyang'ana micron imagwiritsidwa ntchito kwambiri.

Zosangalatsa! Mankhwalawa adapangidwa ndi kampani yopanga mankhwala a Fortnier Pharma. Ku United States, akhala mankhwala opindulitsa kwambiri a lipid pamsika.

Mankhwala

Ma PPAR ndi ma receptor ama nyukiliya omwe amathandizidwa ndi ma ligands achilengedwe kapena opangidwa, komanso amachulukitsa kapena kuletsa mawonekedwe a mitundu ina. Pali PPA alpha, beta ndi gamma receptors. Pafupifupi mafupa onse amamangiriridwa makamaka ku alpha receptors.

Zotsatira zazikulu za mankhwalawa:

• Imalepheretsa mawu a apolipoprotein C3 (APOC3), omwe amalepheretsa lipoprotein lipase yoyang'anira hydrolysis ya intravascular triglycerides (TG). PPAR-alpha imachulukitsa ntchito ya lipoprotein lipase, yomwe imachepetsa kuchuluka kwa triglycerides m'magazi
• Imathandizira kapangidwe ka APOA1, APOA2 ndipo motero HDL
• Panthawi ya mayesero azachipatala omwe amachitika ndi fenofibrate, cholesterol yathunthu ya magazi idatsika pakati pa 20 ndi 25%, ndipo HDL idakwera kuchokera 10 mpaka 30%
• Amachepetsa mawu a endothelin-1, omwe ndi vasoconstrictor wamphamvu. Komanso, ndi makina awa, ma fibrate amachepetsa kufotokoza kwa ma cytokines, makamaka IL-1 ndi IL-6, chifukwa chake, ali ndi mphamvu yolimbana ndi kutupa. Zimadziwikanso kuti kugwiritsa ntchito PPAR-alpha, ma fiber ena amatha kuchepetsa kufotokozera kwa fibrinogen, chifukwa chake amatha kukhala ndi vuto la antithrombotic
• Kuchulukitsa katulutsidwe wa cholesterol ndi bile, komwe kumatha kuyambitsa lithogeneis.

Pulma yayikulu kwambiri ya plasma (Cmax) imatheka patadutsa maola awiri atadutsa pakamwa. Bioavailability amachepetsa kwambiri ngati mankhwalawo atengedwa ndi chakudya. Pambuyo pakukonzekera pakamwa, fenofibrate imatulutsidwa mofulumira ndi ma esterase mu metabolite yogwira - fenofibric acid. Fenofibric acid imagwirizanitsidwa kwambiri ndi plasma albin (oposa 98%). Palibe fenofibrate yosasinthika yomwe idapezeka mu plasma. Mankhwala si gawo limodzi la cytochrome P450. Mankhwalawa sakukhudzidwa ndi hepatic microsomal metabolism.

Mankhwala amachotsedwa m'thupi makamaka ndi mkodzo. Pafupifupi mankhwala onse amachotsedwa mu sabata limodzi. Fenofibrate nthawi zambiri amachotsedwa mu mawonekedwe a fenofibric acid ndi mpweya wambiri wa glucuroconjugate. Mwa odwala okalamba, kutsimikizika kwa fenofibric acid sikusintha. Maphunziro a Pharmacokinetic pambuyo pa limodzi lokha mankhwala mosalekeza amawonetsa kusapeza. Fenofibric acid samachotsedwa mwa njira za dialysis. Hafu ya moyo ndi pafupifupi maola 20.

Zizindikiro zogwiritsidwa ntchito

Mtengo wapakati wa Fenofibrate ndi ma ruble 800 aku Russia.

Fenofibrate imagwiritsidwa ntchito kuwonjezera pa zakudya kapena zina zopanda mankhwala (monga masewera olimbitsa thupi, kuchepa thupi) pochizira mtundu II, III, IV ndi V hyperlipidemia. Fenofibrate iyenera kungotengedwa ngati mankhwala a mzere wachiwiri. Mankhwalawa amatha kugwiritsidwa ntchito pokhapokha pakuwonetsetsa kuchuluka kwa lipids m'magazi. Iyenera kugwiritsidwanso ntchito ngati njira ina yina yogwira kuchokera ku gulu la statin ikalephera kugwira ntchito kapena ikupangika.

Mu maphunziro, chithandizo cha fenofibrate chinachepetsa pafupipafupi matenda a mtima mu matenda a mtima. Komabe, sizinapezeke kuti mankhwalawa ali ndi phindu pakulimbikitsa matenda a mtima.

Malangizo ogwiritsira ntchito

Malinga ndi malangizo, fenofibrate nthawi zambiri imatengedwa kamodzi patsiku. Kudya munthawi yomweyo kumachepetsa bioavailability ya mankhwala. Ndikulimbikitsidwa kumwa piritsi yomwe idatengedwa ndi madzi.

Gwiritsani ntchito panthawi yomwe muli ndi pakati komanso yoyamwitsa sizikulimbikitsidwa, chifukwa, mogwirizana ndi malangizo ogwiritsira ntchito, mankhwalawa ali ndi mphamvu ya teratogenic.

Contraindication, zotsatira zoyipa, mankhwala osokoneza bongo, kuyanjana kwa mankhwala

Fenofibrate imatsutsana ngati vuto la hypersensitivity, nephropathy, kuperewera kwa chiwindi, kukanika kwa hepatic, matenda a gallbladder, chithunzi chomaliza kapena chithunzi chojambulidwa kale. Ngati khungu photosensitivity (chithunzi cha poizoni) ndi redness, maluwa, bloating ndi kuyabwa, chophatikizacho ndichofunika kusiya.

Ndikulimbikitsidwa kuti nthawi yomweyo muuzeko dokotala za kupweteka, kufooka, komanso minyewa. Amayi omwe ali ndi vuto lotenga ana ayenera kuyang'anira chidwi chakubereka kwapakati pa chithandizo.

Fenofibrate imayambitsa kukhumudwa m'mimba ndi m'mimba, kumawonjezera michere ya chiwindi, ndende ya homocysteine. Zimayambitsanso kupweteka kwa minofu, zotupa zoyipa, ma gallstones, ndikuwonjezera milingo ya creatine kinase. Kafukufuku wachipatala adawulula kuti mankhwalawa amatha kubweretsa chisokonezo chachikulu pogwiritsa ntchito nthawi yayitali.

Kuchita mankhwala osokoneza bongo ndikotheka ndi anticoagulants pamlomo, cyclosporine, hepatotoxic zinthu ndi monoamine oxidase blockers. Fenofibrate ndi zoletsa zina za cytochrome P450 isoforms.

Zofananira zazikulu za Fenofibrate: Fenofibrate Canon ndi Tricor.

Fenofibrat Canon

Wopanga - Canonfarm Production CJSC (Russian Federation)

Mtengo - kuchokera ku 820 rubles

Kufotokozera - mapiritsi okhala ndi filimu omwe amagwiritsidwa ntchito pochiza lipids yamagazi ambiri

Ubwino - Amachepetsa kuchuluka kwa lipoproteins otsika kwambiri otsika kwambiri, kumawonjezera HDL ndipo ali ndi antithrombotic zotsatira Mlingo wazithandizo

Chidwi - Amayambitsa kutopa, kupweteka mutu, kukhumudwa, m'mimba, chiwindi ndi kulephera kwaimpso

Wopanga - Recipharm Fontaine (France)

Mtengo - kuchokera 1200 rubles

Kufotokozera - mapiritsi okhala ndi filimu okhala ndi fenofibrate yoyeserera, yomwe imagwiritsidwa ntchito pochotsa kuchuluka kwa cholesterol ndi triglycerides m'magazi

Ubwino - imachepetsa ndende ya LDL, VLDL, fibrinogen ndikuwonjezera HDL. Zomwe zimakhala ndi zotupa ndi uric acid m'magazi nazo zimachepa.

Chidwi - Amayambitsa dyspepsia, chiwindi michere, jaundice, ndulu, rhabdomyolysis, kukanika kwa erectile komanso cephalgia

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapangidwa mwanjira ya mapiritsi okhala ndi ulusi. Chigawo chilichonse cha mankhwalawa chimakhala ndi fenofibrate ya 145, 160 kapena 180 mg ya micenized fenofibrate. Monga zina zomwe zimagwiritsidwa ntchito:

• shuga mkaka
• cellcrystalline mapadi,
• crospovidone
• hypopellose,
• dehydrogenated silicon dioxide kolloidal,
• sucrose
• mafuta a lauryl sodium komanso profusate wa sodium,
• magnesium wakuba.

Mankhwalawa amapangidwa mwanjira ya mapiritsi okhala ndi ulusi.

Chipolopolo chakunja chimakhala ndi talc, xanthan chingamu, titanium dioxide, mowa wa polyvinyl ndi soya lecithin. Mapiritsi oyera ali ndi mawonekedwe amkati ndipo amalemba mbali zonse ziwiri za mawonekedwe, ndikuwonetsa zilembo zoyambirira ndi mulingo.

Njira yamachitidwe

Mapiritsi a Fenofibrate ali m'gulu la othandizira a hypoglycemic ndipo amachokera ku fibroic acid. Thupi limatha kukhudza milingo ya lipids mthupi.

Mphamvu ya pharmacological imachitika chifukwa cha kutsegulira kwa RAPP-alpha (receptor yokhazikitsidwa ndi peroxisis proliferator). Zotsatira zake zowonjezera, njira ya metabolic ya kusweka kwamafuta ndi chimbudzi cha otsika osalimba a plopma lipoproteins (LDL) zimatheka. Kapangidwe ka apoproteins AI ndi AH kumakulitsidwa, chifukwa chomwe mulingo wa lipoproteins yapamwamba (HDL) ukuwonjezeka ndi 10-30% ndipo lipoprotein lipase imayambitsa.

Chifukwa chobwezeretsanso mafuta kagayidwe kachakudya popanga VPLL, fenofibrate pawiri imachulukitsa kuchulukitsidwa kwa LDL, kumachepetsa kuchuluka kwa zigawo zingapo za lipoproteins otsika ochepa.

Miyezo ya LDL imachulukitsidwa kwa odwala omwe ali pachiwopsezo chotenga matenda a mtima.

Mankhwala amathandizira kuchepetsa cholesterol ndi 20-25% ndi triglycerides ndi 40-55%. Pamaso pa hypercholesterolemia, kuchuluka kwa cholesterol komwe kumakhudzana ndi LDL kumatsika mpaka 35%, pomwe hyperuricemia ndi atherosulinosis imachepa m'magazi a uric acid m'magazi ndi 25%.

Pharmacokinetics

Tikutenga pakamwa, michere yolumikizira thupi ya fenofibrate imatengedwa m'chigawo chaching'ono cha m'matumbo aang'ono pogwiritsa ntchito microvilli, kuchokera komwe imalowa m'mitsempha yamagazi. Ikalowa m'matumbo, chinthu chogwira ntchito nthawi yomweyo chimayamba kugonjera fenofibroic acid ndi hydrolysis yokhala ndi ma esterases. Chovunda chimafikira milingo yambiri ya plasma mkati mwa maola 2-4. Kudya pa kuchuluka kwa mayamwidwe ndi bioavailability sikukukhudza chifukwa nanoparticles.

Ikalowa m'matumbo, chinthu chogwira ntchito nthawi yomweyo chimayamba kugonjera fenofibroic acid ndi hydrolysis yokhala ndi ma esterases.

M'magazi, gawo lothandizira limamangidwa ku plasma albin ndi 99%. Mankhwala satenga nawo mbali microsomal metabolism. Hafu ya moyo wafika mpaka maola 20. Munthawi ya mayeso azachipatala, panalibe milandu yokondweretsa onse limodzi ndi amisala ambiri. Hemodialysis siyothandiza. Mankhwalawa amachotsedwa mu mawonekedwe a fenofibroic acid m'masiku 6 kudzera mu kwamikodzo.

Contraindication

Mankhwalawa sanatchulidwe chifukwa chotsatira motsutsana:

• Hypersensitivity kuti fenofibrate ndi zina mwazinthu zinthu za mankhwala,
• matenda a chiwindi
• kukanika kwa aimpso,
• cholowa cha galactosemia ndi fructosemia, kuchepa kwa lactase ndi sucrose, kuphwanya shuga ndi mayamwidwe a galactose,
• mbiri yamatenda obadwa nawo a minofu,
• kupepuka kwa mankhwala ataphatikizidwa ndi Ketoprofen kapena ma fiber ena,
• kagayidwe kachakudya matenda mu ndulu.

Mankhwala sinafotokozeredwe cholowa cha galactosemia.
Mankhwalawa sanatchulidwe matenda a chiwindi.
Mankhwala sinafotokozeredwe ngati chibadwa cha fructosemia.
Mankhwala sinafotokozedwe chifukwa cha kukanika kwa aimpso.
Mankhwalawa sanatchulidwe matenda amtundu wa makolo.
Mankhwala sinafotokozeredwe ma pathological mu gallbladder.

Anthu omwe ali ndi anaphylactoid amatani ndi mtedza ndi batala la nandolo sayenera kumwa mankhwalawo.

Gulu lazachipatala, INN, kuchuluka

Fenofibrate ndi wa gulu lapadera - mankhwala ochepetsa lipid omwe amapangidwa pamaziko a fibroic acid. Mankhwala oterewa amatha kuchepetsa bwino kuchuluka kwa cholesterol yoyipa m'magazi ndikuchepetsa kuchuluka kwa triglycerides.

Mankhwalawa amagwiritsidwa ntchito kuchepetsa kuchuluka kwa lipids, kuchuluka kwambiri komwe kumakhudza thanzi la munthu. Nthawi zambiri amalembedwa kwa odwala omwe ali ndi matenda a shuga, omwe amapezeka ndi mtima ndi mitsempha yamagazi (mwachitsanzo, mtima ischemia, atherosulinosis) kuti athe kukonza mulidi ya lipids.

INN ndi Fenofibrate, chifukwa ndi gawo ili lomwe limapangidwa ndimankhwala ndipo limafotokoza momwe limagwirira ntchito poyenda mthupi.

Fomu yotulutsidwa, mtengo ku Russia

Mankhwalawa amasulidwa ngati mapiritsi okhala ndi mtundu woyera, mawonekedwe ozunguliridwa komanso gawo logawanika. Piritsi lililonse lili ndi 145 mg yogwira pophika. Zodzala ndi matuza a pulasitiki amtundu wa 7, 10 kapena 15. Pazonse, pabokosi lamakatoni pamapezeka mapiritsi 10 mpaka 100.

Mtengo wake umatengera kuchuluka kwa mapiritsi omwe ali phukusili, komanso malo ogulira mankhwalawo. Mitengo ya phukusi la mapiritsi 30 a 145 mg m'masitolo am'mizinda yayikulu ya Russia imawonetsedwa.

Mitengo yotsika mtengo kwambiri imaperekedwa ndi malo ogulitsa pa intaneti. Pamenepo mutha kuyitanitsa kutumiza mwachangu kunyumba kwanu.

Zophatikizira

Chofunikira chachikulu cha mankhwalawa ndi fenofibrate. Amatchedwa fibroic acid derivatives (fibrate). Piritsi limodzi lili ndi 145 mg pazinthu izi. Kuphatikiza apo, kapangidwe ka mankhwalawa amaphatikiza zinthu monga - cellulose, magnesium stearate, povidone, mannitol, starch, silicon dioxide. Ali ndi ntchito yothandiza.

Zachuma

Fenofibrate imatha kuyambitsa alpha receptors (RAPP) yodziwika bwino. Izi zimabweretsa kukulira kwa lipolysis ndi kuchotsedwa kwa ma lipoprotein oopsa otsika magazi, omwe amatha kudzikundikira ndikuyika pamakoma amitsempha yamagazi, zomwe zimabweretsa zotsatira zoyipa. Pankhaniyi, zotsatirazi zikuwonekera:

• kutsika kwa triglycerides ndi cholesterol yoyipa,
• kutsika kwa kuchuluka kwa uric acid (uricosuric zotsatira),

machulukitsidwe a kupatsidwa zinthu za m'mwazi (kupewa thrombosis),

Pambuyo pakamwa, mankhwalawa amadzaza kwathunthu m'matumbo atatha maola 4. Ngati atengedwa mwadongosolo, ndiye kuti kuchuluka kwa magazi omwe amagwira ntchito kumakhala kosalekeza. Fenofibrate imamangiriza pafupifupi kwathunthu ku mapuloteni amwazi.

Mukukonza kwake fenofibroic acid imapangidwa. Mu microsomal metabolism satenga nawo mbali. Kutupa kumachitika kudzera mu impso. Hafu ya moyo imawonekera maola 20 pambuyo pa utsogoleri. Zimatenga pafupifupi masiku 6 kuti muchotseretu mankhwala a fenoforbit metabolites.

Zizindikiro ndi malire

Mankhwala amathandizidwa kuti achepetse kuchuluka kwa triglycerides ndi mafuta ochepa otsika cholesterol omwe ali ndi ma pathologies:

Dyslipidemia wosakaniza. Nthawi zambiri amakumana ndi matenda otere:

• matenda ashuga
• ischemia
• machitidwe atherosulinotic mu zotumphukira kapena carotid mitsempha,
• zam'mimba mitsempha,
• zovuta zina zama coronary. Mankhwala nthawi zambiri amagwiritsidwa ntchito limodzi ndi ma statins kuti achepetse triglycerides ndikuwonjezera HDL (cholesterol yopindulitsa).

Kutalika kwa nthawi komanso chithandizo chamankhwala zimatsimikiziridwa ndi adokotala. Musanapereke mankhwala, muyenera kuwonetsetsa kuti wodwala alibe zotsutsana ndi izi:

• kusalolera payekha pazinthu zomwe zimapanga mankhwala,
• kulephera kwambiri kwaimpso
• Hypersensitivity ku fibrate ndi Ketoprofen,
• kutsekeka kwa ndulu,
• aakulu kapamba kapamba (kupatula komwe amayamba chifukwa cha hypertriglyceridemia),
• ana ndi achinyamata,
• nthawi GW,
• mimba
• chiwindi ntchito.

Mankhwalawa sanayesedwe pa ana ang'ono, amayi apakati, ndi amayi oyamwitsa. Chifukwa chake, chiwopsezo chotheka cha kuchuluka kwa anthu sichidziwika. Popeza fenofibrate imatha kulowa mkati mwa placenta ndikulowetsa mkaka wa m'mawere, sizikulimbikitsidwa kuti muzigwiritsa ntchito kuti musavulaze mwana.

Mosamala kwambiri komanso moyang'aniridwa ndi dokotala, mankhwalawa amagwiritsidwa ntchito ngati hypothyroidism, matenda a impso, komanso mankhwalawa kwa odwala okalamba komanso anthu omwe amamwa mowa kwambiri.

Malangizo ogwiritsira ntchito

Ndikofunikira kutenga fenofibrate molondola. Izi zikuthandizira malangizo ogwiritsa ntchito, omwe amalimbikitsa:

1. Tengani mapiritsiwo mkati osatafuna ndi madzi.
2. Mankhwalawa amamwa kamodzi patsiku, kuphatikiza kudya kwake ndi kudya kwakanthawi (kotero kumatha kuyamwa).
3. Mlingo wa mankhwalawa osiyanasiyana a pathologies ndi 145 mg patsiku. Odwala okalamba safuna kusintha kwa mlingo.

Fenofibrate iyenera kutengedwa kwa nthawi yayitali. Pankhaniyi, zakudya zapadera za hypocholesterol ziyenera kuchitika.

Pakapita kanthawi (pafupifupi miyezi itatu chichitikireni chithandizo), magazi a wodwalayo amayenera kupimidwa kuti awone zoyenera. Ngati izi sizinawoneke, muyenera kusintha mlingo kapena kusintha mtundu wa mankhwalawo.

Kuyanjana kwa mankhwala osokoneza bongo

Mankhwalawa amatha kugwiritsidwa ntchito molumikizana ndi kutali ndi mankhwala onse. Nayi zitsanzo za momwe amachitira ndi mankhwala ena:

1. Ndi makonzedwe munthawi yomweyo ndi ma anticoagulants, mphamvu zawo zimakulitsidwa. Izi zingayambitse magazi. Ngati mukufuna kuzigwiritsa ntchito nthawi yomweyo, ndiye kuti kuchuluka kwa anticoagulants kumachepetsedwa katatu.
2. Fenofibrate ndi cyclosporine, akatengedwa pamodzi, zimayipitsa kuyipa kwa impso.
3. Kugwiritsa ntchito limodzi ndi ma fiber ena kumawonjezera chiopsezo cha kuwonongeka kwa poizoni.

Malangizo apadera

Ndikofunika kuphunzira malangizo apadera musanagwiritse ntchito mankhwalawa. Zina mwa izo ndi:

1. Mankhwalawa sagwira ntchito ngati simuchotsa matenda omwe adapangitsa kuti milingo ya lipid iwonjezeke.
2. Mukamamwa mankhwalawa, muyenera kutsatira zakudya zomwe zili ndi mafuta ochepa a cholesterol.
3. Kuchita bwino kwa mankhwalawa kungayesedwe ndi zotsatira za kuyezetsa magazi pazomwe zili ndi cholesterol yonse, LDL, triglycerides.
4. Ngati wodwala akutenga mankhwala a mahomoni, ndiye kuti muyenera kudziwa ngati kuchuluka kwa milomo ya lipid sikukuchitika chifukwa cha vuto la mahomoni.
5. M'chaka choyamba chomwa mankhwalawa, tikulimbikitsidwa kuyang'anira kuchuluka kwa hepatic transaminases (ALT ndi AST).

Miyezo ALT ndi AST

Njira zoterezi zimatha kuwonjezera phindu la mankhwalawo, komanso kupewa zomwe zingachitike ndi zovuta zina.

Zotsatira zoyipa, zizindikiro za bongo

Mankhwalawa ali ndi zovuta zokwanira. Nthawi zambiri zimatuluka chifukwa chosagwiritsidwa ntchito molakwika. Pankhaniyi, odwala amatha:

• zovuta zam'mimba, zomwe zimawonetsedwa ndi mseru, kusanza, kubala, kupweteka m'mimba, kutsekula m'mimba,
• kapamba
• Kapangidwe ka miyala mumiyala ya bile,
• kukula kwa chiwindi (chowonetsedwa ndi jaundice, kuyabwa kwa khungu),
• kupindika, kufooka kwa minofu ndi kuwawa,
• kuchuluka kwa maselo oyera am'magazi ndi hemoglobin,
• mutu
• kuphwanya zogonana,
• thromboembolism, leukocytosis,
• pachimake aimpso kulephera
• zotupa zako m'mapapu
• kutaya tsitsi
• thupi lawo siligwirizana pakhungu monga redness, kuyabwa, zotupa, urticaria,
• Photophobia.

Mankhwala osokoneza bongo ndi osowa kwambiri. Pankhaniyi, wodwalayo ayenera kupita kuchipatala. Amachita chithandizo chamankhwala. Ndikosatheka kuchotsa mankhwalawa ndi hemodialysis.

Momwemonso

Fenofibrate amatanthauza othandizira a hypoglycemic. Mapangidwe ake okhala ndi zinthu zomwe zimagwira. Odziwika kwambiri a:

1. Tricor ndiwotchipa koma mankhwala apamwamba kwambiri ochokera ku France.
2. Lipantil ndi mankhwala aku France omwe ali ndi 200 mg ya fenofibrate piritsi limodzi.
3. Exlip ndi mankhwala othandizira otulutsidwa ku Turkey okhala ndi 250 mg ya fenofibrate.

Mankhwala ena ali ndizinthu zina, koma zimathandizanso. Zina mwa izo ndi:

1. Atorvacor. Mankhwala ali ndi yogwira mankhwala atorvastatin ndipo choletsa HMG-CoA reductase. Amagwiritsidwa ntchito pa hyperlipidemia.
2. Livostor. Chidacho chilinso ndi atorvastatin. Ndi mankhwala otchipa kutsitsa mafuta m'thupi.
3. Tulip. Amapangidwa ndi kampani yopanga mankhwala Sandoz ku Poland. Atorvastatin imagwira ntchito ngati yogwira ntchito.

Ndalama zotere zimagwiritsidwa ntchito pakusalolera kuti fenofibrate. Gawani analogue imodzi kapena ina ingangokhala ndi dokotala wokhazikika.

Ndemanga za madotolo ndi odwala

Kuti muwone kuyipa kwa mankhwalawa, ndikofunikira kudziwa zomwe madotolo ndi odwala awo akunena za Fenofibrate. Nawa malingaliro enieni:

Fenofibrate ya mankhwala ndi mankhwala othandiza pochiritsa hyperlipidemia. Ubwino wake wagona pakuphatikizika kwa zinthu zomwe zimagwira m'magazi, zomwe zimapangitsa kuti zikhale zofunikira - kuchepa kwa LDL ndi triglycerides.

Momwe mungatenge Fenofibrate

Mapiritsi amatengedwa popanda kutafuna. Odwala achikulire ayenera kumwa mankhwala okwanira 145 mg patsiku. Mukamasintha mlingo wa 165, 180 mg kukhala mlingo wa tsiku lililonse wa 145 mg, kusintha kowonjezereka kwa chizolowezi chatsiku ndi tsiku sikofunikira.

Mankhwala tikulimbikitsidwa kuti kumwedwa kwa nthawi yayitali poyerekeza ndi maziko a mankhwala oyenera. Kuchita bwino kwa mankhwalawa kuyenera kuwunikiridwa pafupipafupi ndi adotolo kutengera ndi zomwe zili serum lipid.

Mapiritsi amatengedwa popanda kutafuna.

Pakati mantha dongosolo

Kuwonongeka kwa Erectile ndi mutu kumatha kuchitika ndi zovuta m'mitsempha yamanjenje.

Ngati mulingo woyenera wa mankhwalawa, zotsatira zoyipa zimatha kuoneka ngati mukugwidwa.
Ndi mulingo woyenera wa mankhwalawa, zotsatira zoyipa zimatha kuoneka ngati ululu wa minofu.
Ndi mulingo woyenera wa mankhwalawa, zotsatira zoyipa zimatha kuoneka ngati zotupa pakhungu.
Ndi mulingo woyenera wa mankhwalawa, zotsatira zoyipa zitha kuoneka ngati zikuwonjezera kuchuluka kwa maselo oyera amwazi m'magazi.
Ngati mulingo woyenera wa mankhwalawa, zotsatira zoyipa za m'mimba zimatha kuonekera.
Ndi mlingo woyenera wa mankhwalawa, zotsatira zoyipa zimatha kuoneka ngati zasanza.
Ndi mulingo woyenera wa mankhwalawa, zotsatira zoyipa zimatha kuoneka ngati tsitsi latha.

Kuchokera ku genitourinary system

Panalibe kusintha koyipa mu ntchito ya kwamikodzo.

Nthawi zambiri, zotupa pakhungu, photosensitivity (kudziwa kuwala), kuyabwa kapena ming'oma yofatsa kuti ivute pang'ono. Nthawi zina, kuchepa kwa tsitsi, maonekedwe a erythema, matuza kapena mafinya a minye yolumikizidwa mothandizidwa ndi ma radiation a ultraviolet amawonedwa.

Zokhudza mphamvu pakuwongolera njira

Kutenga Fenofibrate sikukhudza kuzunzika, thupi komanso psychoemotional reaction, chifukwa chake, munthawi yamankhwala ochepetsa lipid, kuyendetsa galimoto ndikugwira ntchito ndi zida zovuta kumaloledwa.

Panthawi yomwe mumamwa mankhwalawa, kuyendetsa galimoto ndikugwira ntchito ndi zida zovuta kumaloledwa.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

M'maphunziro azachipatala pazinyama, palibe teratogenic zotsatira zomwe zimapezeka. M'maphunziro oyambira, kuwopsa kwa thupi la mayi ndikuyika chiopsezo kwa mwana wosabadwayo kulembedwa, chifukwa chake, mankhwalawa amatengedwa pokhapokha ngati mayiyo ali ndi mwayi wokhudzana ndi intrauterine anomalies mwa mwana.

Kuyamwitsa pa mankhwala kumathetsedwa.

Kupangira Fenofibrate kwa Ana

Mankhwala osavomerezeka kwa ana ndi achinyamata ochepera zaka 18 chifukwa chosowa chidziwitso cha mphamvu ya Fenofibrate pakukula ndi kukula kwa thupi.

Mankhwala osavomerezeka kwa ana ndi achinyamata ochepera zaka 18.
Kuyamwitsa pa mankhwala ndi mankhwala kwathetsedwa.
Kumwa mankhwalawa panthawi yoyembekezera kumachitika pokhapokha ngati mayiyo ali ndi mwayi wambiri yodutsika mwa mwana.

Bongo

Panalibe milandu ya bongo chifukwa cha kugwiritsa ntchito mankhwala osokoneza bongo. Palibe gulu linalake lotsutsa. Chifukwa chake, ngati wodwala wokhala ndi mlingo umodzi wapamwamba wayamba kudwala, kukulira kapena zovuta zake kumachitika, ndikofunikira kufunafuna chithandizo chamankhwala. Ndi kuchipatala, mawonekedwe owonetsa a bongo amathetsedwa.

Kuchita ndi mankhwala ena

Kuphatikiza fenofibrate ndi anticoagulants pakamwa, mphamvu ya mankhwala omwe amafunsidwa imawonjezeka. Ndi kuyanjana uku, chiopsezo chotuluka magazi chikuwonjezeka chifukwa chakuchotsa kwa anticoagulant kuchokera ku mapuloteni amadzi a plasma.

Ndi kugwiritsidwa ntchito komweko kwa HMG-CoA reductase blockers, chiopsezo cha kutchulidwa kwa poizoni wamisempha chimakulanso, chifukwa chake ngati wodwala atenga ma statins, ndikofunikira kusiya mankhwalawo.

Cyclosporine imathandizira kuti impso ziwonongeke, chifukwa chake mukamamwa Fenofibrate, muyenera kuwunika momwe thupi lilili. Ngati ndi kotheka, kukhazikitsa mankhwala a hypolipidemic kwathetsedwa.

Kuyenderana ndi mowa

Pa mankhwala ndi Fenofibrate, ndizoletsedwa kumwa mowa. Mowa wa Ethyl umafooketsa mphamvu ya mankhwalawa.

Mitu yake ya mankhwalawa imaphatikizanso mankhwala omwe ali ndi machitidwe ofanana:

• Tricor
• Atorvacor
• Lipantil
• Cyprofibrate,
• Canon Fenofibrate mapiritsi,
• Livostor
• Exlip,
• Trilipix.

Kusinthira ku mankhwala ena kumachitika pambuyo pofunsa kuchipatala.

Malangizo a Tricor Lipantil 200 M malangizo Phenofibrate malangizo a CanON

Zosungidwa zamankhwala

Ndikulimbikitsidwa kusunga mankhwalawo pamtunda mpaka + 25 ° C pamalo owuma, omwe amakhala kutali ndi dzuwa.

Ndikulimbikitsidwa kusunga mankhwalawo pamtunda mpaka + 25 ° C pamalo owuma, omwe amakhala kutali ndi dzuwa.

Fenofibrate Ndemanga

Pali ndemanga zolimbikitsa kuchokera kwa akatswiri azamankhwala ndi odwala.

Olga Zhikhareva, katswiri wa zamtima, Moscow

Kugwiritsa ntchito polimbana ndi ma triglycerides okwera. Ndikupangira kugwiritsa ntchito mitundu IIa, IIb, III ndi IV hyperlipoproteinemia. Muzochitika zamankhwala, ndimapereka kuthekera kwa makonzedwe ndi mlingo pa munthu aliyense payekha. Palibe mavuto omwe adawonedwa. Zilibe tanthauzo kutulutsa cholesterol.

Afanasy Prokhorov, wothandizira zakudya, Yekaterinburg

Ndi kunenepa kwambiri komanso cholesterol yambiri, fenofibroic acid imathandiza bwino. Makamaka ndi zochepa mphamvu zolimbitsa thupi ndi kudya. Panthawi yachipatala, ndimalimbikitsa kusiya zizolowezi zoipa ndikutsatira malangizo a dotolo kuti ndichite bwino.

Nazar Dmitriev, wazaka 34, Magnitogorsk

Njira yabwino yothetsera. Lipids anali 5.4. Pogwiritsa ntchito Fenofibrate pafupipafupi, kuchuluka kwa mafuta kunatsikira mpaka 1.32. Borderline anali 1.7. Palibe zoyipa zomwe zidanenedwa.

Anton Makaevsky, wazaka 29, St. Petersburg

Anatenga pafupifupi chaka m'malo mwa Torvacard chifukwa cha zochepa zomwe zinali ndi HDL. Pambuyo pa miyezi 4-5 ya kukhazikitsa, kuukira kwa mseru komanso kupweteka pamimba yapamwamba kunayamba kuonekera. Pambuyo pa miyezi 8-9, adachita opareshoni yochotsa gallbladder. Mwala wamiyala yosemphana ndi miyala yopanda tanthauzo. Pambuyo pa opareshoni, kuukira kunatha.

Mikhail Taizhsky, wazaka 53, Irkutsk

Mankhwalawa anamwa kuti alimbikitse makhoma a mtima, koma sindinganene za chochitikacho. Zotengera sizimveka. Mothandizidwa ndi mankhwalawa, kunenepa kunachepa chifukwa cha njala, koma khungu linachepa kwambiri. Ntchito yobwezeretsa ikufunika. Ndine wokhutira ndi zotsatira zake.