Acekardol mapiritsi - zikuchokera ndi zikuwonetsa, limagwirira zake ndi contraindication, analogues ndi mtengo

Mankhwala "Acecardol" ndi acetylsalicylic acid, wokutira, amene amasungunuka mwachindunji m'matumbo. Ndi mankhwala osakhala a steroidal okhala ndi anti-yotupa. Acetylsalicylic acid imaphatikizidwa mu Mlingo wosiyanasiyana mu mitundu yonse ya Acecardol.

Imatha kuletsa kaphatikizidwe ka thromboxane ndikulepheretsa kuphatikiza mapulateleti m'magulu. Mphamvu ya Acecardol imawonedwa ngakhale ndi milingo yaying'ono yamagwiritsidwe ake ndipo imapitilira ntchito kamodzi sabata limodzi. Mlingo wambiri, mankhwalawa ali ndi antipyretic, analgesic komanso anti-yotupa.

Piritsi limodzi lili ndi 50, 100 kapena 300 mg yogwira mankhwala acetylsalicylic acid. Mankhwalawa ndi a gulu lachipatala komanso zamankhwala a NSAIDs, antiplatelet agent.

Maziko a machitidwe a kuchitapo kanthu ndikuthekera kwa choletsa cycloo oxygenase ndi chigawo chogwira ntchito, chomwe chimayambitsa zoletsa za thromboxane A2 komanso kuchepa kwa kuphatikizana kwa maselo. Mphamvu ya antiplatelet yomwe imatheka pakumwa piritsi limodzi imatha sabata limodzi.

Zisonyezero zakugwiritsa ntchito Acecardol

Acecardol imalepheretsa thrombosis, kuletsa kukulitsa ndi kupitilira kwa kugunda kwa mtima, kukwapula kwa ischemic, ndi thromboembolism. Kugwiritsidwa ntchito kwa nthawi yayitali kwa acecardol kumawonjezera nthawi yayitali komanso moyo wa odwala. Odwala omwe anali atavutika ndi vuto la mtima wosachedwa kuwunika adazindikira kuwongolera kwawo, thanzi lawo komanso kupanikizika kwawo.

Acecardol imapangidwira osakhazikika angina pectoris, kupewa infarction wobwerezabwereza, kupewa pulmonary embolism (kuphatikiza nthambi zake) komanso deep vein thrombosis (mwachitsanzo, pakatha nthawi yayitali opaleshoni).

Malangizo ogwiritsira ntchito Mlingo wa Acecardol

Lankhulani ndi dokotala wanu za mtundu wabwino kwambiri wa tsiku ndi tsiku. Kukonzekera kwa acetylsalicylic acid kwa 50-150 mg patsiku cholinga chake ndikugwiritsa ntchito kwa nthawi yayitali. Monga lamulo, amapatsidwa moyo wonse ngati palibe zovuta zoyipa.

Pali mitundu ya mankhwala omwe amagwiritsidwa ntchito popewa matenda osiyanasiyana. Pofuna kupewa kulowetsedwa kwachimake kwam'maso, popanda komanso ngati pali chiopsezo, thromboembolism yam'mapapo m'mimba ndi nthambi zake, vein thrombosis yozama imaperekedwa 100 mg tsiku lililonse kapena 300 mg tsiku lililonse lachiwiri (ndikofunikira kutafuna piritsi loyambirira).

Zolemba zogwiritsira ntchito

Mukamamwa mankhwalawa Acekardol, muyenera kusamala mukamayendetsa magalimoto, zida zamagetsi komanso pochita zinthu zina zoopsa zomwe zimafuna kuti anthu azikumbukira mwachangu komanso mwachangu ma psychomotor reaction.

Munthawi yamankhwala ndikukonzekera malinga ndi acetylsalicylic acid, kuyezetsa magazi kuyenera kutengedwa nthawi zonse, chifukwa mankhwalawa amathandizira kuti ziwonjezeke. Pogwiritsa ntchito acecardol kwa nthawi yayitali komanso mosasamala, chiopsezo chotulutsa magazi mkati nchachikulu.

Mukamamwa pamodzi nthawi yomweyo ndi zakumwa zoledzeretsa, kuwopsa kwa magazi kumawonjezeka ndipo nthawi yawo imakulirakulira, ndipo chiwopsezo cha kuwonongeka kwa nembanemba yam'mimba imachepa.

Acecardol imapangitsa zotsatira za mankhwala monga:

- methotrexate,
- heparin,
- insulin
- mtima glycosides.

Acekardol - mapiritsiwo akuchokera kuti

Madokotala amalembera mapiritsi a Acekardol pazifukwa zodzitetezera, atachitidwa opaleshoni pamtima ndi mitsempha ya magazi kapena kupewa ngozi yachiwiri yodwala omwe adakumana nayo kale. Kumverera kosasangalatsa komanso kupweteka m'dera lachifuwa (angina pectoris) kumathandizanso ngati chifukwa choyambira kutenga Acecardol monga gawo lofunikira la mankhwala osokoneza bongo.

Malinga ndi malangizo ogwiritsira ntchito, Acekardol ndi m'gulu la antiplatelet mankhwala. Kuchita kwake kuli ndi cholinga chopewa kuphatikizika (masakanizidwe) a maselo othandiza magazi kuundana. Mphamvu ya mankhwalawa Acekardol pamayendedwe a hematopoiesis ndikuthandizira kuchuluka kwa ma capillaries, kuchepa kwa magazi, komwe kumachitika chifukwa cha zomwe zimachitika mu mtima ndi m'mitsempha yamagazi.

Wogwira ntchito yemwe amapanga maziko a mankhwala acecardol ndi acetylsalicylic acid, yemwe amadziwika chifukwa cha zotsatira zake zowonjezera. Zinthu zotsatirazi zimagwiritsidwa ntchito ngati gawo lothandizirana pa kuchuluka kwaperesenti:

• polyvinylpyrrolidone wochepa maselo - 1,8%,
• wowuma chimanga - 9.5%,
• microcrystalline ufa wazomera polysaccharide (mapadi) - 5.6%,
• stearic acid (kapena magnesium stearate) - 0,6%,
• talc - 1.7%
• shuga wa mkaka monohydrate (lactose) - 53%.

Kutulutsa Fomu

Mkhalidwe wa mankhwalawa Acecardol, momwe maupangidwe ake achire amawonekera bwino, ndi piritsi yolumikizidwa ndi chipolopolo chokhala ndi asidi loyera lomwe limagwira ntchito ya 50, 100 kapena 300 mg. Kapangidwe kake komwe kamapangidwira kumapereka zinthu m'matumbo osungunuka (zoteteza mankhwala):

• cellulose acetate - amalepheretsa kusungunuka kwammero,
• titaniyumu diabolosi - amachepetsa mphamvu ya hydrochloric acid,
• mafuta a castor (ricinoleic acid) - imathandizira ndikufulumizitsa kudutsa kwa mapiritsi kudzera kum'mero.

Pharmacodynamics ndi pharmacokinetics

Makina a zochita za antiplatelet agent Acekardol, mogwirizana ndi malangizo ogwiritsira ntchito, adakhazikika pa kutsekereza mwayi wopezeka ndi ma thromboxanes ku gawo la cycloo oxygenase. Njira yoletsa imathandizira kuyimitsa kaphatikizidwe ka prostanoids ndi kuponderesa kuphatikizika kwa maselo, chifukwa chomwe zotsatira za antipyretic, kuchepetsa ululu ndi kuthetseratu kwa zizindikiro za kutupa zimatheka.

Mankhwala Acekardol, olowa m'matumbo pambuyo pakukonzekera pakamwa, amataya mawonekedwe ake oteteza asidi, ndipo asidi amene amamasulidwa amayamba kulowa m'matumbo aang'ono. Patatha maola atatu mutamwa Acecardol, kuchuluka kwa zinthu zomwe zili m'madzi a m'magazi kumafikiridwa. Kutupa kwa mankhwalawa kumachitika ndi tubular aimpso secretion (60% mu mawonekedwe osasinthika, 40% mu mawonekedwe a metabolites).

Acecardol - zikuonetsa kuti mugwiritse ntchito

Mankhwala a antiplatelet amathandizira kupewa magazi kuundana komanso pochiza matenda obwera. Acecardol, malinga ndi malangizo, akuwonetsedwa kuti agwiritse ntchito kupewa izi:

• postoperative thromboembolism (pambuyo pang'onopang'ono, ochepa angioplasty),
• kuchuluka kwa matenda a mtima (chizindikiro chachikulu ndikosakhazikika kwa angina)
• sitiroko
• myocardial infarction (ngati pali zinthu zomwe zimabweretsa chiwopsezo monga matenda a shuga, kunenepa kwambiri, ukalamba, ndi zina zambiri).
• magazi amayika m'mitsempha yakuya.

Contraindication

Chifukwa cha kukhalapo kwa ulcerogenic acetylsalicylic acid mu kapangidwe ka Acecardol, kugwiritsa ntchito mankhwalawa kumapangidwa mwa ana osaposa zaka 18 komanso mwa odwala omwe ali ndi matenda olembedwa m'mbiri ya matendawa:

• matenda a impso kapena chiwindi.
• magazi ochulukirapo
• magazi m'matumbo a m'mimba,
• mphumu ya bronchial kuphatikizapo polyposis yammphuno,
• kukokoloka kwa msana.

Mlingo ndi makonzedwe

Malangizo ogwiritsira ntchito ali ndi ndandanda yotsatirika pakutenga piritsi la Acecardol. Kupitilira muyeso womwe wasonyezedwa ndikusintha njira yogwiritsira ntchito mankhwalawa osavomerezeka popanda chilolezo cha dokotala. Mankhwalawa amayenera kulowa m'matumbo popanda kuwononga mawonekedwe a membrane, chifukwa amayenera kumeza lonse ndikutsukidwa ndi madzi ambiri. Acecardol ayenera kumwedwa musanadye. Pofuna kupewa zovuta pa mucosa, mapiritsi amatha kutsukidwa ndi madzi amchere amchere.

Mukamamwa Acecardol popewa matenda, malangizo otsatirawa ayenera kutsatiridwa:

Zotsatira zoyipa ndi contraindication Acekardol

Malinga ndi ndemanga ndi zodandaula za boma, Acecardol ikhoza kuyambitsa mavuto osiyanasiyana.

• Kuchokera pamimba: kukhumudwa, kupweteka kwamtima, kusanza, kupweteka kwam'mimba, zilonda zam'mimba zam'mimba ndi duodenum, zilonda zam'mimba ndi duodenum, kutaya magazi m'mimba, kusokonezeka kwa chiwindi kwakanthawi ndi kuchuluka kwa ntchito ya hepatic transaminases.
• Kuchokera ku hemopoietic dongosolo: kuikidwa kwa ASA kumayendetsedwa ndi chiopsezo chotaya magazi chifukwa cha kuletsa kwa ASA pa kuphatikizika kwa maselo a magazi, kuchepa magazi.
• Thupi lawo siligwirizana: zotupa pakhungu, kuyabwa, urticaria, edema ya Quincke, rhinitis, kutupa kwa mphuno, mtima, komanso kuthana kwambiri.
• Kuchokera pakupuma dongosolo: bronchospasm.
• Kuchokera kumbali ya chapakati mantha dongosolo: chizungulire, kufooka, kumva kuwawa, mutu, tinnitus.

Zotsatira zoyipa, kutulutsa magazi mukamazula mano, mphuno pazoyipa za vuto la matenda oopsa nthawi zambiri zimadziwika. Odwala ambiri amadandaula ndi kutentha kwa mtima atatenga Acecardol.

Ngakhale mukukhudzidwa ndi zotsatira zoyipa, simuyenera kusiya kusankha kumwa Acekardol. Lankhulani ndi dokotala wanu ngati mutha kusiya acetylsalicylic acid kapena m'malo mwake ndi china. Magazini azachipatala achilendo achenjeza kuti nthawi yoyamba itatha kumwa kwa aspirin tsiku ndi tsiku mwa odwala, nthawi zambiri pamakhala kutsekeka kwamitsempha yamagazi ndimagazi am'magazi, kugunda kwa mtima komanso sitiroko yamphamvu chifukwa cha "mphamvu yotulutsa".

Bongo

Zizindikiro zakuchuluka kwamphamvu kupuma: nseru, kusanza, tinnitus, kumva, chizungulire, kusokonezeka kowoneka, chisokonezo.

Chithandizo: kuchepetsa mlingo.

Mankhwala ochulukirapo a Acecardol amawopseza pulmonary edema, kumangidwa kwa mtima, kulephera kwaimpso, hyperglycemia ndi hypoglycemia. Pankhani ya bongo wambiri, pamakhala chiwopsezo chachikulu chotukuka msanga kwa m'mimba ndi magazi m'matumbo.

Ngati bongo waukali kwambiri, zotsatirazi zimachitika: kuchipatala mwachangu m'madipatimenti apadera othandizira chithandizo chamankhwala - chapamimba, kutsimikiza kwa asidi-base, alkaline ndi kukakamizidwa kwa alkaline diuresis, hemodialysis, kutsata mayankho, kuyambitsa makala, makala.

Zoyipa:

• m'mimba,
• kukokoloka, zilonda zam'mimba,
• Mphumu ya bronchial yomwe ikukula komanso kukhululuka,
• hemorrhagic diathesis,
• kulephera kwa mtima
• ana ochepera zaka 18,
• polyposis ya paranasal sinuses ndi mphuno.

Ndi zoletsedwa kumwa mankhwalawa Acekardol, analogues ndi kukonzekera kofanana panthawi ya bere (nthawi yonse yomwe ali ndi pakati) ndi kuyamwitsa. Komanso contraindication imatha kuganiziridwa payekhapayekha ngati acetylsalicylic acid ndi zinthu zina zothandiza popanga mankhwala, makamaka lactose.

Contraindified mu kwambiri aimpso kulephera (creatinine chilolezo (CC) zosakwana 30 ml / min). Mosamala komanso pokhapokha poyang'aniridwa ndi katswiri, mankhwala amathandizidwa kuti apewe vuto la impso (CC zoposa 30 ml / min).

Acecardol analogs, mndandanda

Analogs a Acecardol ndi mankhwala (mndandanda):

Chofunikira - malangizo ogwiritsa ntchito Acecardol, mtengo ndi kuwunika sizigwira ntchito pa analogues ndipo sizingagwiritsidwe ntchito ngati chitsogozo pakugwiritsa ntchito mankhwala omwe ali ndi kapangidwe kake. Nthawi zonse zochizira ziyenera kupangidwa ndi dokotala. Mukasintha Acecardol ndi analogue, ndikofunikira kuti mupeze upangiri waluso, mungafunike kusintha njira zamankhwala, mankhwalawa, etc. Osadziletsa!

Ndemanga za madotolo za mankhwala Acekardol ndi zabwino. Madokotala amati mapiritsiwa ndi abwino poletsa kupewa kubwereza kwa mtima, ma stroko, komanso thrombosis atachitidwa opaleshoni ndikuchita ntchito yabwino.

Odwala omwe adalandira chithandizo chamankhwala amati ngati simutafuna piritsi, ndiye kuti sipadzakhala vuto m'mimba mutatha kumwa. Izi zimapereka kuphatikizika kwa piritsi kwa mawonekedwe a piritsi. Chachikulu ndikutsatira mlingo womwe dokotala wanu wakupatsani. Komanso, chidwi chazinthu zabwino popewa komanso kuchiza magazi zimatsimikiziridwa ndi odwala.