GLYCLAZIDE MV

Glyclazide MB ndi kukonzekera kwa pakamwa kwa hypoglycemic kokhudzana ndi zotengera za sulfonylurea za m'badwo wachiwiri. Mankhwala:

1. imathandizira kupanga insulin,
2. umapangitsa mphamvu ya insulin-secretory ya shuga,
3. amachepetsa shuga
4. kumawonjezera chidwi cha insulini mu zotumphukira.
5. sinthana msanga wa kudya glycemia,
6. amachepetsa kupanga shuga m'magazi,
7. Kuphatikiza pa kukhudza kagayidwe kazakudya, mankhwala amathandizira kusintha kwakapangidwe kakang'ono.

Glyclazide imachepetsa chiwopsezo cha kuundana kwa magazi m'mitsempha yaying'ono, kukhudza nthawi imodzimodziyo njira ziwiri zomwe zimakhudzidwa pakupanga zovuta za matenda osokoneza bongo:

• zoletsa zochepa za kuphatikiza kwa kupatsidwa zinthu za m'mwazi komanso kuphatikiza,
• kuchira
• Pofuna kuchepetsa kupatsidwa zinthu za m'magazi (thromboxane B_2, beta thromboglobulin).

Contraindication

• mtundu 1 shuga
• chidwi chachikulu ndi Glyclazide kapena zigawo zikuluzikulu za mankhwalawo (kuti sulfonamides, zotumphukira za sulfonylurea),
• mimba ndi mkaka wa m`mawere
• pachimake chiwindi kapena impso,
• kutenga miconazole,
• wodwala matenda ashuga
• matenda a shuga
• matenda ashuga ketoacidosis,
• wazaka 18
• kuchepa kwa lactase
• kobadwa nako lactose tsankho,
• Madokotala salimbikitsa kugwiritsa ntchito mankhwalawa limodzi ndi danazol kapena phenylbutazone.

Kodi muyenera kumwedwa mosamala

Gliclazide silingagwiritsidwe ntchito popanda mankhwala, chifukwa mankhwalawa sioyenera aliyense. Nayi mndandanda wazinthu zomwe ziyenera kugwiritsidwa ntchito mosamala:

1. zoperewera kapena zosakhazikika,
2. ukalamba
3. hypothyroidism
4. pituitary kapena adrenal kusowa,
5. matenda oopsa a mtima dongosolo (atherosulinosis, matenda a mtima),
6. hypopituitarism,
7. glucocorticosteroid wa nthawi yayitali,
8. chiwindi kapena matenda a impso,
9. shuga-6-phosphate dehydrogenase akusowa,
10. uchidakwa.

Tcherani khutu! Mankhwalawa amangolembera achikulire okha!

Momwe mungatengere panthawi yoyembekezera komanso yoyamwitsa

Palibe zambiri pakugwiritsa ntchito mankhwalawa panthawi yopaka bere. Zambiri pakugwiritsa ntchito zina za sulfonylurea zochokera panthawi ya pakati ndizochepa.

M'maphunziro a labotale nyama, teratogenic zotsatira za mankhwala sizinapezeke. Kuti muchepetse chiopsezo cha kubadwa mwatsopano, muyenera kuwongolera matenda a shuga.

Zofunika! Hypoglycemic ya pakamwa mankhwala pa nthawi ya pakati siikudziwika. Zochizira matenda a shuga nthawi yapakati, insulin ya mankhwala imasankhidwa. Kulandila kwa mankhwala a hypoglycemic tikulimbikitsidwa kuti m'malo mwake mukhale ndi insulin.

Kuphatikiza apo, lamuloli limagwira ntchito pa nthawi yomwe mayi amakhala ndi pakati pa nthawi yomwe amamwa mankhwalawa, ndipo ngati kutenga pakati kumangophatikizidwa mu malingaliro a mkazi.

Popeza kuti palibe chidziwitso pakumwa mankhwala mkaka wa m'mawere, chiopsezo chokhala ndi fetal hypoglycemia sichitha. Momwemo, kugwiritsa ntchito Gliclazide panthawi yoyamwitsa kumatsutsana.

Malangizo ndi mlingo

30 mg mapiritsi otulutsidwa-mapiritsi amayenera kumwa nthawi 1 pa tsiku kadzutsa. Wodwala akalandira chithandizo koyamba, mlingo woyambirira uyenera kukhala 30 mg, izi zimagwiranso ntchito kwa anthu azaka zopitilira 65. Pang'onopang'ono musinthe muyezo mpaka chithandizocho chichitike.

Kusankha kwa mlingo kumalimbikitsidwa malinga ndi kuchuluka kwa shuga m'magazi pambuyo poyambira chithandizo. Kusintha kwa mtundu wina uliwonse kumachitika pokhapokha pakatha milungu iwiri.

Glyclazide MB ikhoza m'malo mwa mapiritsi a Glyclazide ndikutulutsa wamba (80 mg) muyezo wa tsiku ndi tsiku wa zidutswa za 1-4. Ngati pazifukwa zina wodwalayo adaphonya mankhwalawo, mlingo wotsatira sayenera kukhala wokwera.

Ngati mapiritsi a Glyclazide MB 30 mg amagwiritsidwa ntchito kuti alowe m'malo mwa mankhwala ena a hypoglycemic, nthawi yosintha siyofunikira pamenepa. Ndikofunikira kuti mumalize kudya kwa tsiku lililonse kwa mankhwala am'mbuyomu ndipo tsiku lotsatira mutenge Gliclazide MB.

Zofunika! Ngati wodwalayo adachitidwapo kale mankhwala a sulfonylureas ndi theka lalitali, kuwunika mosamala kuchuluka kwa shuga m'magazi ndikofunikira kwa masabata awiri.

Izi ndizofunikira popewa kukula kwa hypoglycemia, yomwe imatha kuwoneka motsutsana ndi maziko azomwe zotsalira zamankhwala am'mbuyomu.

Mankhwalawa akhoza kuphatikizidwa ndi alpha-glucosidase inhibitors, biguanides kapena insulin. Odwala omwe amalephera kupweteka pang'ono, kapena aimpso, Gliclazide MB imafotokozedwa muyezo umodzi wa odwala omwe ali ndi vuto laimpso. Mankhwala contraindicated mu kwambiri aimpso kulephera.

Odwala omwe ali pachiwopsezo cha hypoglycemia

Odwala ali pachiwopsezo cha kukhala ndi hypoglycemia:

1. wopanda nkhawa kapena wopanda chakudya,
2. ndi zovuta zowalipitsa kapena zovuta za endocrine (hypothyroidism, adrenal and pituitary insufficiency),
3. Ndi kuthetsedwa kwa othandizira a hypoglycemic atatha nthawi yayitali,
4. Ndi mitundu yoopsa ya mtima methologies (atherosulinosis, carotid arteriosulinosis, matenda a mtima),

Kwa odwala oterowo, Glyclazide MB ya mankhwala imayikidwa muyezo waukulu (30 mg).

Zotsatira zoyipa

Mankhwalawa amatha kuyambitsa glycemia, yomwe imawonetsedwa ndi zizindikiro zotsatirazi:

• njala
• kutopa, kufooka kwambiri,
• mutu, chizungulire,
• thukuta kwambiri, kunjenjemera, paresis,
• arrhasmia, palpitations, bradycardia,
• kuthamanga kwa magazi
• kugona, kugona,
• kusakwiya, kuda nkhawa, kupsa mtima, kukhumudwa,
• chipwirikiti
• kusokonezeka ndende,
• kuchepa kwapang'onopang'ono ndi kulephera kulolera,
• zovuta zamaganizidwe
• kuwonongeka kwamawonekedwe
• aphasia
• kulephera kudziletsa
• kumva wopanda thandizo
• kupuma kosakhazikika
• kukokana
• delirium
• kutaya chikumbumtima.

1. erythema
2. zotupa pakhungu
3. urticaria
4. kuyabwa kwa khungu.

Pali zovuta zoyipa zomwe zimapezeka m'matumbo am'mimba:

• kupweteka kwam'mimba
• kudzimbidwa
• kusanza, kusanza,
• kawirikawiri cholestatic jaundice hepatitis, koma amafunikira kusiya mankhwalawa mwachangu.

Mankhwala osokoneza bongo komanso kuyanjana

Ngati mulibe mlingo wokwanira, mwayi wokhala ndi vuto lalikulu la hypoglycemic, womwe umatha kutsatiridwa ndi zovuta zamitsempha, kukhumudwa, chikomokere, ndichabwino. Pakuwonekera koyamba kwa zizindikirazi, wodwala amafunikira kuchipatala mwachangu.

Ngati vutoli la hypoglycemic ikukayikiridwa kapena kupezeka, yankho la dextrose 40-50% limaperekedwa kudzera kwa odwala. Pambuyo pake, amaika dontho lokhala ndi 5% dextrose solution, komwe ndikofunikira kuti pakhale shuga m'magazi.

Wodwalayo akadziwikanso, kuti apewe kubwereza kwa hypoglycemia, ayenera kupatsidwa chakudya chambiri m'zakudya zopatsa mphamvu. Izi zimatsatiridwa ndikuwunika mosamala kuchuluka kwa shuga m'magazi ndikuwunika wodwalayo maola 48 otsatira.

Zochita zina, kutengera mtundu wa wodwalayo, zimasankhidwa ndi adokotala. Chifukwa chakumangika kwa mankhwalawo kumapuloteni a plasma, dialysis siyothandiza.

Glyclazide imawonjezera mphamvu ya ma anticoagulants (warfarin), zokhazokha ndikuti mungafunike kusintha mlingo wa anticoagulant.

Danazole limodzi ndi Gliclazide ndi odwala matenda ashuga. Onse pakugwiritsa ntchito danazol ndipo atachotsa, kusintha kwa glucose ndi kusintha kwa Glyclazide kumafunika.

Systemic makonzedwe a phenylbutazone timapitiriza hypoglycemic zotsatira za Gliclazide (amachepetsa kuchotsa m'thupi, amachoka pamagulu kulumikizana ndi mapuloteni am magazi). Kuwunika kwa glyclazide ndi kuyang'anira shuga wamagazi ndikofunikira. Onse pa nthawi ya kutenga phenylbutazone, ndipo atasiya.

Ndi makonzedwe a Miconazole ndipo mukamagwiritsa ntchito gel osakaniza pakamwa, imalimbitsa mphamvu ya Hypoglycemic, mpaka kukula kwa chikomokere.

Ethanol ndi zotumphukira zake zimakulitsa hypoglycemia, zimatha kubweretsa kukula kwa chikumbumtima cha hypoglycemic.

Mukagwiritsidwa ntchito limodzi ndi mankhwala ena a hypoglycemic (biguanides, acarbose, insulin), fluconazole, beta-blockers, H2-histamine receptor blockers (cimetidine), angiotensin-converting enzyme inhibitors (enalapril, Captoprilamide antioxidants, non-steroidal sulfide inhibitors Hypoglycemic zotsatira, motero, chiopsezo cha hypoglycemia.

Chlorpromazine mu waukulu Mlingo (woposa 100 mg / tsiku) kumawonjezera kuchuluka kwa shuga m'magazi, kutsekereza chinsinsi cha insulin. Onse panthawi yogwiritsa ntchito chlorpromazine ndipo atachotsa, kuwongolera kwa glucose ndikusintha kwa Gliclazide pamafunika.

GCS (rectal, kunja, intraarticular, systemic use) imachulukitsa shuga wamagazi ndikuthekera kwa ketoacidosis. Onse panthawi yogwiritsa ntchito GCS ndipo atachotsedwa, kuwongolera kwa glucose ndikusintha kwa Gliclazide pamafunika.

Terbutaline salbutamol, erythrocyte wosakhazikika - amalimbikitsa shuga. Kuwongolera shuga m'magazi ndikofunikira, ndipo ngati kuli kotheka, kusinthana ndi insulin.

Malangizo apadera ndi mawonekedwe omasulira

Mankhwala Gliclazide MB amagwira ntchito pokhapokha ngati amadya zakudya zochepa zopatsa mphamvu, zomwe zimakhala ndi mafuta ochepa. Kuwunikira pafupipafupi kuchuluka kwa shuga, ponseponse pamimba yopanda kanthu ndikudya. Izi ndizofunikira makamaka poyambira kulandira chithandizo.

Mukamalandira mankhwalawa, kuti mupewe kuvulala ndi ngozi pamsewu, tikulimbikitsidwa kupewa kuyendetsa magalimoto ndikugwira ntchito ndi zida zowopsa zomwe zimafunikira chidwi chachikulu komanso kuthamanga.

30 mg mapiritsi, okhala ndi matuza a zidutswa 10.

Moyo wa alumali wa Gliclazide ndi zaka 3, pambuyo pake sungagwiritsidwe ntchito. Mankhwalawa amayenera kusungidwa pamalo owuma, amdima komanso ozizira, osagwirizana ndi ana.

M'madera osiyanasiyana adzikoli, mtengo wa mankhwalawa umasiyana ndi ma ruble 120 mpaka 150. Tikulankhula za phukusi lomwe lili ndi miyala 60. Pali ma CD mu zitini za ma polima. Mbale umodzi kapena matuza 1 mpaka 6 amayikidwa m'bokosi.

Kusiyana kwa mtengo kumadalira zinthu zosiyanasiyana: wopanga, dera, malo a mankhwala.

Njira yogwiritsira ntchito

Zokhudza pakamwa. Mankhwala Gliclazide MV Cholinga cha akulu okha.
Mlingo wa tsiku ndi tsiku wa MV Glyclazide ukhoza kusiyana 30 mg mpaka 120 mg. Ndikulimbikitsidwa kuti muthe nthawi 1 pa tsiku mukamadya kadzutsa, muzimeza miyala yonse osatafuna.
Ngati mungadumphe kumwa mankhwalawa, simungathe kuwonjezera mlingo tsiku lotsatira.!
Monga mankhwala ena a hypoglycemic, muyeso wa mankhwalawa nthawi iliyonse uyenera kusankhidwa payekhapayekha, kutengera momwe wodwalayo amagwirira ntchito.
Mlingo woyambitsidwa woyamba ndi 30 mg (piritsi limodzi la Gliclazda MV ndi mlingo wa 30 mg kapena 1 2 mapiritsi ndi mlingo wa 60 mg).
Pankhani yogwiritsa ntchito bwino kuchuluka kwa shuga m'magazi, mankhwalawa angagwiritsidwe ntchito ngati mankhwala ochizira.
Ngati palibe utsogoleri wokwanira wama glucose, muyezo mulingo ungakulitse pang'onopang'ono mpaka 60 mg, 90 mg kapena 120 mg patsiku. Mlingo pakati pakubwera mosiyanasiyana muyezo wa mankhwalawa uyenera kukhala osachepera mwezi umodzi, pokhapokha magazi a shuga sawonjezeka pambuyo pa milungu iwiri. Zikatero, mlingowo ungathe kuwonjezereka kale masabata awiri atayamba chithandizo.
Pazipita la tsiku lililonse lofika 120 mg.
Piritsi imodzi ya 60 mg Glyclazide MV yosinthidwa ndiyofanana ndi mapiritsi awiri a 30 mg Gliclazide MV osinthika. Piritsi ya Glyclazide MV 60 mg yosinthika ndikosavuta kugawa, zomwe zimapangitsa kuti mulingo wa mankhwalawo usinthidwe.
Gwiritsani ntchito limodzi ndi mankhwala ena a antidiabetes
Gliclazide MB ikhoza kugwiritsidwa ntchito limodzi ndi biguanidines, alpha-glucosidase inhibitors kapena insulin. Kwa odwala omwe shuga ya m'magazi ake sawongolera mokwanira chifukwa chotenga Glyclazide MV, chithandizo cha insulin chitha kuperekedwa moyang'aniridwa ndi achipatala.
Anthu okalamba
Mlingo wovomerezeka wa okalamba ndi wofanana ndi wa akulu wazaka zosakwana 65.
Kulephera kwina
Mlingo woyenera wa mankhwala aimpso kulephera kufatsa pang'ono pang'ono ali ofanana ndi anthu omwe ali ndi vuto laimpso.
Odwala omwe ali ndi chiopsezo chowonjezeka cha hypoglycemia: kuperewera kwa zakudya m'thupi, zovuta za endocrine zowonongeka kwambiri kapena kuchepa kwa magazi,
- Pambuyo kuchotsedwa kwa kale komanso / kapena yayikulu corticosteroid mankhwala, mu mtima kwambiri matenda (kwambiri coronary matenda a mtima, carotid mtsempha wamagazi, kusokoneza mitsempha).
Ndi bwino kupereka mankhwala osachepera tsiku lililonse 30 mg.

Zotsatira zoyipa:
Chithandizo Glyclazide MV kumatha kudzetsa vuto la hypoglycemia pakagwiritsidwe ntchito ka zakudya zosavomerezeka makamaka makamaka pakudumphira chakudya.
Zizindikiro zotheka za hypoglycemia: kupweteka mutu, kupweteka kwambiri, kusanza, kusokonezeka, kugona tulo, kusokonezeka, kuyika chidwi pang'ono, kuchepa kwa kupenda momwe zinthu zikuyendera, kupsinjika, chikumbumtima chosazindikira, vuto lakumayang'ana komanso kulankhula, aphasia, kunjenjemera , paresis, kuchepa kwa chidwi, chizungulire, kumva kusowa pogwira, kulephera kudziletsa, kusokonekera kwa boma, kukokana, kupuma kosasunthika, bradycardia, kugona komanso kusazindikira, zomwe zingayambitse kusamba kapena kupha.

Kuphatikiza apo, zizindikiro za kutsutsa kwa adrenergic monga kutuluka thukuta, khungu la mtima, nkhawa, tachycardia, kuthamanga kwa magazi, kugunda kwa mtima, angina pectoris ndi mtima arrhasmia.
Nthawi zambiri zizindikirozi zimatha pambuyo pa kudya chakudya chamagulu (shuga). Nthawi yomweyo, zotsekemera zamagetsi sizikhala ndi zoterezi.
Masewera ovuta kwambiri a hypoglycemia, ngakhale atatha kuthetsedwa pang'ono ndi shuga, ndikofunikira kupereka chithandizo chamankhwala kapena, ngati kuli kotheka, ngakhale kugulitsa wodwala kuchipatala.
Zotsatira zina zosafunikira:
matenda am'mimba dongosolo (nseru, kutsegula m'mimba, kumva kupsinjika m'mimba, kudzimbidwa, kupweteka pamimba, kusanza, nseru). Zizindikirozi sizachilendo pakaikidwe ka Gliclazide MV nthawi ya chakudya cham'mawa.
Zotsatira zake sizodziwika bwino:
thupi lawo siligwirizana: kuyabwa, urticaria, maculopapular zidzolo,
kuchokera ku hematopoietic ndi lymphatic system: kusintha kwa ma hematological. Izi zitha kukhala magazi m'thupi, leukopenia, thrombocytopenia, granulocytopenia. Zizindikiro zambiri zimatha mukasiya kumwa mankhwalawa,
kusokonezeka kwa chiwindi ndi ndulu chikhodzodzo: kuchuluka kwa michere ya "chiwindi" (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase), hepatitis (milandu yotalikirana).Ngati cholestatic jaundice ikupezeka, chithandizo chikuyenera kutha. Zizindikiro zambiri zimatha mukasiya kumwa mankhwalawa,
matenda a ophthalmological: kufooka kowonera.

Kuchita ndi mankhwala ena

Nthawi zina n`kofunika kusintha mlingo wa antidiabetesic wothandizila panthawi ndi pambuyo danazol mankhwala.
Pangakhale kofunikira kusintha muyezo wa mankhwala a antidiabetesic panthawiyi komanso mukamaliza kukonzekera danazol.
Kuphatikiza komwe kumafunikira kusamala mwapadera.
Chlorpromazine: Mlingo waukulu (woposa 100 mg patsiku) umachulukitsa kuchuluka kwa shuga m'magazi, kumachepetsa katemera wa insulin.
Glucocorticosteroids (makonzedwe achilengedwe ndi apakhungu: makulidwe amkati, khungu ndi makona) ndi tetracosactrin kumachulukitsa shuga m'magazi ndikutukuka kwa ketoacidosis (kuchepa kwa chakudya chambiri ndi glucocorticosteroids).
Progestogens: Mphamvu ya anthu odwala matenda ashuga amene amapezeka kwambiri. β-2-adrenostimulants - ritodrin, salbutamol, terbutaline: (wogwiritsa ntchito): shuga wowonjezera.
Yang'anani makamaka pakufunika kwakudziyang'anira nokha shuga. Ngati ndi kotheka, sinthani wodwala kupita ku insulin.
Ngati mukufuna kugwiritsa ntchito mitunduyi pamwambapa, muyenera kuyang'anira kwambiri kuchuluka kwa shuga m'magazi. Pangakhale kofunikira kuwonjezera pakusintha kwa MV Glyclazide onse munthawi yophatikiza mankhwala atasiya kumwa mankhwala ena.
Kuphatikiza kwa kulingalira.
Kulandila kwa mankhwala a anticoagulant (warfarin): Kulandila mankhwala a sulfonylurea kungakulitse mphamvu ya anticoagulant mwa mankhwalawa. Kusintha kwa mankhwalawa kwa anticoagulant kungafunike.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu:
Odwala akutenga Gliclazide MV, ayenera kudziwa zizindikiro za hypoglycemia ndikugwiritsa ntchito mosamala mukamayendetsa kapena kugwira ntchito yofunika kuthamanga kwambiri kwamthupi ndi m'maganizo.

Malo osungira

Pamalo otetezedwa ku chinyezi ndi kuwala pa kutentha kosaposa 25 ° C.
Pewani kufikira ana.

Tsiku lotha ntchito:
Mlingo wa 30 mg, moyo wa alumali ndi chaka chimodzi.
Mlingo wa 60 mg, moyo wa alumali ndi zaka ziwiri.
Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Kutulutsa Fomu

Mankhwala Gliclazide MV operekedwa mu mawonekedwe tzosintha kumasulidwa zotulutsa:
Mapiritsi ozungulira a zoyera kapena pafupifupi zoyera ndi mawonekedwe a cylindrical ndi bevel (mlingo wa 30 mg).
Mapiritsi ozungulira a mtundu oyera kapena pafupifupi oyera wokhala ndi mawonekedwe a cylindrical ndi chamfer komanso chiwopsezo (Mlingo wa 60 mg).
Mapiritsi 10 okhala ndi matuza. Matumba atatu kapena asanu ndi chimodzi, pamodzi ndi malangizo ogwiritsira ntchito paketi yamakhadi.