Glucophage mavuto

Ngakhale pali zinthu zabwino za mankhwalawo, Glucophage, zoyipa zomwe aliyense ayenera kudziwa, ali ndi zina zomwe angagwiritse ntchito.

Kuphatikiza apo, wopangayo amapanga Glucofage Long, mankhwala amkamwa omwe amagwiritsidwa ntchito kuti awonjezere kuyankha kwa ma receptor ku timadzi totsitsa-shuga, komanso kugwiritsa ntchito shuga ndi maselo.

Nkhaniyi ikuthandizira kumvetsetsa zinthu zofunika monga magwiritsidwe, ntchito, mavuto kuchokera ku glucophage, contraindication, kuwunika, mitengo yamtengo wapatali ndi analogues.

Mankhwala

Mankhwala Glucophage amasonyezedwa kwa odwala omwe samadalira insulin, pomwe kuchita masewera olimbitsa thupi komanso zakudya zapadera sizithandiza kutsika kwamisempha. Malangizowo akuti othandizira odwala matenda ashuga amatha kugwira ntchito ngati kunenepa kwambiri kumachitika. Pochita, zimaphatikizidwa ndi zonse insulin mankhwala ndi mitundu ingapo yochepetsera shuga.

Wopanga amatulutsa Glucophage antidiabetesic wothandizira mu mapiritsi a mitundu yosiyanasiyana: 500, 850 ndi 1000 mg. Chomwe chimagwiritsa ntchito mankhwalawa ndi metformin hydrochloride - woimira kalasi yayikulu. Piritsi lililonse la mankhwalawa limaphatikizapo zinthu monga povidone, macrogol (4000, 8000), hypromellose ndi magnesium stearate.

Mtundu wapadera wamasulidwa ndi mankhwala omwe akhala akuchita kwa nthawi yayitali. Mapiritsi amapangidwa mosiyanasiyana Mlingo (Glucofage Long 500 ndi Glucofage Long 750).

Glucophage siyikutsogolera kukula kwa hypoglycemia, ndipo palibenso kulumikizana kowongoka kuzidziwitso zamagulu a shuga. Mukamatenga Glucofage mwa anthu athanzi, palibe kuchepa kwa glycemia yomwe ili pansi pa malire a 3.3-5.5 mmol / L. Matenda a shuga amakwaniritsidwa chifukwa cha mankhwala otsatirawa:

1. Kupanga insulin kwa beta maselo a beta.
2. Kuchuluka kwa chiwopsezo cha "maselo chandamale" mapuloteni ndi adipose minofu ya insulin.
3. Kupititsa patsogolo kwa kukonza kwa dzuwa ndi minyewa.
4. Kuchepetsa chakudya cham'mimba mwa chimbudzi.
5. Kutsitsa kuchuluka kwa shuga chiwindi.
6. Kupititsa patsogolo kagayidwe.
7. Kuchepetsa kuzama kwa cholesterol, otsika ochepa lipoproteins ndi triglycerides.
8. Kuchepetsa thupi kwa odwala omwe ali ndi kunenepa kwambiri (Glucofage acidifying acid acid).

Pogwiritsidwa ntchito pakamwa pa Glucofage metformin, hydrochloride imalowa mwachangu m'matumbo am'mimba, ndipo mawonekedwe ake apamwamba amawonekera pambuyo pa maola awiri ndi theka. Glucophage Long, mmalo mwake, imamizidwa nthawi yayitali, chifukwa chake imangotengedwa kamodzi kokha pa tsiku.

Gawo logwira ntchito silikugwirizana ndi mapuloteni, omwe amafalikira mwachangu kuzinthu zonse zama cell a thupi. Metformin imakumbidwa limodzi ndi mkodzo.

Anthu omwe ali ndi vuto la impso ayenera kudziwa kufunikira kwa kuletsa kwa mankhwala mu minofu.

Malangizo ogwiritsira ntchito mapiritsi

Mankhwalawa onse (Glucophage ndi Glucophage Long) amagulidwa ku mankhwala, okhala ndi malangizo a endocrinologist nawo. Dokotalayo amapereka mankhwala malinga ndi kuchuluka kwa glucose komanso Zizindikiro za munthu wodwala matenda ashuga.

Kumayambiriro kwa mankhwalawa, tikulimbikitsidwa kugwiritsa ntchito 500 mg kawiri pa tsiku. Pakatha milungu iwiri, amaloledwa kuwonjezera Mlingo. Tiyenera kudziwa kuti mutatenga Glucofage woyamba masiku 10 mpaka 14 pali zotsatira zoyipa zomwe zimakhudzana ndi kusintha kwa thupi ndi gawo lomwe limagwira. Odwala amadandaula za kusokoneza kwam'mimba, monga, kugwidwa ndi mseru kapena kusanza, kudzimbidwa kapena, matendawa, kutsekemera kwazitsulo.

Mlingo wokonza ndi 1500-2000 mg patsiku.Kuti muchepetse mavuto chifukwa chomwa mankhwalawa, muyenera kugawa mlingo wa tsiku ndi tsiku katatu. Zolemba malire patsiku zimaloledwa kudya mpaka 3000 mg.

Ngati wodwalayo agwiritsa ntchito mankhwala ena a hypoglycemic, ndiye kuti ayenera kusiya kudya ndi kuyamba kulandira chithandizo ndi Glucofage. Mukaphatikiza mankhwalawa ndi insulin, muyenera kutsatira mlingo wa 500 kapena 850 mg kawiri kapena katatu patsiku, komanso 1000 mg kamodzi patsiku. Anthu omwe ali ndi vuto la kulephera kwa impso kapena matenda ena a impso, ndikofunika kusankha mlingo wa mankhwalawa payekhapayekha. Zikatero, anthu odwala matenda ashuga amapanga kamodzi mwa miyezi 3-6.

Gwiritsani ntchito Glucofage Long 500 ndiyofunikira kamodzi patsiku madzulo. Mankhwalawa amasinthidwa kamodzi pakatha milungu iwiri iliyonse. Glucophage Long 500 ndi koletsedwa kugwiritsa ntchito zoposa kawiri pa tsiku. Ponena za kuchuluka kwa 750 mg, ziyenera kudziwika kuti kuchuluka kwambiri kumakhala kawiri pa tsiku.

Kwa odwala aubwana ndi unyamata (wopitilira zaka 10) amaloledwa kudya mpaka 2000 mg patsiku. Kwa odwala opitilira zaka zopitilira 60, dotoloyo amasankha payekha chifukwa cha kuchepa kwa impso.

Mapiritsiwo amatsukidwa ndi kapu yamadzi opanda, osaluma kapena kutafuna. Mukaphonya mlingo, simuyenera kuwirikiza kawiri. Kuti muchite izi, muyenera kumwa nthawi yomweyo ya Glucofage.

Kwa odwala omwe amamwa oposa 2000 mg a glucophage, palibe chifukwa chomwa mankhwala omwe atulutsidwa nthawi yayitali.

Mukamagula othandizira odwala matenda ashuga, onetsetsani moyo wake wa alumali, womwe ndi 500 ndi 850 mg wa Glucofage zaka zisanu, komanso Glucofage 1000 mg kwa zaka zitatu. Ulamuliro wa kutentha komwe ma CD amusungiramo sayenera kupitirira 25 ° C.

Chifukwa chake, kodi Glucophage imayambitsa mavuto, ndipo imakhala ndi zotsutsana? Tiyeni tiyese kuzilingalira mopitirira.

Contraindication hypoglycemic mankhwala

Mankhwala omwe amapezeka nthawi yayitali komanso nthawi yayitali amakhala ndi zotsutsana zapadera komanso zoyipa.

Pofuna kupewa zoyipa zomwe zimachitika mutatha kumwa Glucofage, odwala matenda ashuga amafunika kukambirana zonse zamatenda ndi dokotala.

Phukusi lililonse la mankhwalawo limatsagana ndi pepala loyika lomwe limakhala ndi zotsutsana zonse ndi mankhwala a Glucophage.

Main contraindication ndi:

• kuchuluka kwa zinthu zomwe zilimo,
• matenda ashuga ketoacidosis,
• chikomokere, matenda a shuga,
• Kukula kwa ma pathologies omwe amatsogolera kuwoneka kwa minofu hypoxia (myocardial infarction, kupuma / mtima kulephera),
• kukanika kwa chiwindi kapena kulephera kwa chiwindi,
• kuwonongeka kwa impso kapena kulephera kwa aimpso (creatinine osakwana 60 ml mphindi imodzi),
• pachimake zinthu zomwe zimawonjezera mwayi wa kukanika kwa impso (kutsegula m'mimba, kusanza), kugwedezeka, matenda opatsirana,
• kuvulala kwambiri, komanso kuchitapo kanthu pochita opaleshoni,
• nthawi ya bere ndi mkaka wawo,
• uchidakwa, komanso uchidakwa.
• masiku awiri isanachitike komanso itatha mayeso a radioisotope ndi x-ray ndikuyambitsa gawo lokhala ndi ayodini.
• lactacidemia, makamaka m'mbiri.

Kuphatikiza apo, ndizoletsedwa kumwa mankhwalawa ngati mugwiritsa ntchito hypocaloric zakudya (zosakwana 1000 kcal patsiku).

Zotsatira zoyipa ndi bongo

Kodi mavuto amakumana ndi chiyani?

Monga tanena kale, Glucophage imakhudza kugwira ntchito kwa m'mimba thirakiti koyambira kwamankhwala.

Kuzolowera thupi kumayendera limodzi ndi zizindikiro monga mseru, kusanza, mapando otayirira, kudzimbidwa, kulawa kwazitsulo, pakamwa lowuma, kusowa chilakolako cha chakudya, bulimia.

"Zotsatira zoyipa" zimalumikizidwa ndi zovuta zina pakugwira ntchito kwa ziwalo zamkati.

Choyamba, zotsatira zoyipa zimawonetsedwa:

1. Kukula kwa lactic acidosis.
2. Kupezeka kwa kuchepa kwa vitamini B12, komwe kuyenera kutengedwa mozama ndi kuchepa kwa magazi m'thupi.
3. Khungu ndi kusunthika kosiyanasiyana monga pruritus, zotupa, ndi erythema.
4. Zotsatira zoyipa za chiwindi, kukula kwa chiwindi.

Ndi bongo, kukula kwa dziko la hypoglycemic sikunawonedwe. Komabe, lactic acidosis nthawi zina imatha kuchitika. Zizindikiro zomwe zingakhalepo zingaphatikizepo kusazindikira bwino, kukomoka, kusanza, nseru, chizungulire, kupweteka kwa mutu, ndi ena.

Zoyenera kuchita ngati wodwala akuonetsa zizindikiro za lactic acidosis? Iyenera kuperekedwa kuchipatala posachedwa kuti itsimikizire kuchuluka kwa mkaka wa lactate. Monga lamulo, dokotala amamuwonetsa hemodialysis ngati njira yabwino kwambiri yochotsera lactate ndi metformin hydrochloride m'thupi. Chithandizo cha Syndrome chimachitidwanso.

Malangizowo sakusonyeza njira zosaphatikizidwa zomwe zimagwiritsidwa ntchito limodzi ndi Glucofage, zimatha kukweza msanga kapena kuchepa kwa msanga. Simungathe kuphatikiza chithandizo cha Glucofage ndi:

• antipsychotic
• Danazol
• chlorpromazine
• beta2-sympathomimetics
• mankhwala a mahomoni
• zida zodulira
• Mowa.

Kuphatikiza apo, sikulimbikitsidwa kuphatikiza kuyendetsa kwa Glucofage ndi ayodini okhala ndi ayodini.

Kugwiritsa ntchito mankhwalawa pofuna kuchepetsa thupi komanso thanzi la azimayi

Odwala ambiri amadabwa chifukwa chake Glucophage imakhudza kuchepa thupi. Popeza mankhwalawa amathandizira kuti asidi asungidwe zamafuta komanso amachepetsa kugwiritsa ntchito mafuta, zimapangitsa kuchepa kwambiri kwa thupi.

Chimodzi mwazotsatira zoyipa, kulephera kudya, odwala matenda ashuga ambiri amawona kuti ndiothandiza, chifukwa amachepetsa kudya kwawo tsiku ndi tsiku. Komabe, mphamvu ya mankhwalawa imatha kuchepetsedwa chifukwa chakuwonjezeka kwa acidic m'thupi. Chifukwa chake, munthawi yakumwa Glucofage, sizikulimbikitsidwa kuti mudzitopetse ndi masewera olimbitsa thupi. Koma palibe amene anathetsa zakudya zoyenera. Ndikofunikira kusiya zakudya zamafuta ndi kuphatira chakudya cham'mimba mosavuta.

Kutalika kwa mankhwalawa kuonda sikuyenera kupitilira masabata 4-8. Musanagwiritse ntchito mankhwalawa, muyenera kufunsa akatswiri odziwa zaumoyo kuti mupewe kuvulazidwa komanso kukhala ndi hypoglycemia mu matenda a shuga.

Kafukufuku waposachedwa awonetsa kuti kumwa mankhwala ndikothandiza pakubala. Kuphatikiza apo, imatengedwa ndi polycystosis, yomwe idapangitsa kuti 57% ya zolephera kukhala ndi ana. Izi zitha kupezeka chifukwa cha metabolic syndrome kapena kukana insulin.

Poyamba, odwala ambiri amakhala ndi zizindikiro monga kuchedwa, kusakhazikika, komanso cystitis. Zizindikirozi sizikhala bwino ndipo zimafunikira kulumikizidwa mwachangu ndi dokotala wazamankhwala.

Kuphatikiza kwa Glucophage ndi Duphaston kumathandizira kukhazikika kwamadzi.

Mtengo, kuwunika ndi zofanana

Glucophage imadabwitsa osati ndi ntchito yake, komanso mitengo yosangalatsa. Chifukwa chake, mtengo wa 1 phukusi la Glyukofage umasiyana ndi ma ruble a 105 mpaka 310, ndikuchitapo kanthu kwa nthawi yayitali - kuchokera pa ma ruble 320 mpaka 720, kutengera mtundu wa kumasulidwa.

Ndemanga za odwala omwe amamwa mankhwalawa ndi zabwino kwambiri. Glucophage sichimayambitsa hypoglycemia ndipo imakhazikitsa shuga mu odwala matenda ashuga. Komanso, ndemanga zambiri zikuwonetsa kuyenera kwa njira yothetsera kuwonda. Mwachitsanzo, mwachitsanzo, ndemanga:

Lyudmila (wazaka 59): "Ndidawona Glucofage pazaka zitatu zapitazi, shuga sapitirira 7 mmol / L. Inde, kumayambiriro kwamankhwala ndimadwala, koma ndikuganiza ngati mukudwala, mutha kuthana nawo. Ngati mupitiliza kumwa mankhwala, "Zaka zitatu zapitazo, thupi langa linali lolemera makilogalamu 71, ndipo chida ichi cholemera thupi lonse chinatsikira mpaka 64 kg. Muyenera kuvomereza kuti izi ndi zotsatira zabwino. Zachidziwikire, simungachite popanda kudya komanso kulipiritsa zachipatala."

Komabe, pali malingaliro oyipa okhudza mankhwalawa. Amalumikizidwa ndi kudzimbidwa komanso kusintha kwina kwamthupi.Mwachitsanzo, kupanikizika kowonjezereka, kuvuta kwa impso. Komanso, mankhwalawa amatha kuyambitsa kukulira kwa cholecystitis, atrive fibrillation, kuchuluka kwa zizindikiro za psoriasis, mwa anthu omwe akudwala matendawa. Ngakhale ubale weniweni pakati pa matenda ndikumwa mankhwalawa sunakhazikike kwathunthu.

Popeza Glucofage ili ndi chinthu chotchuka padziko lonse lapansi - metformin, imakhala ndi mitundu yambiri. Mwachitsanzo, Metformin, Bagomet, Metfogamma, Formmetin, Nova Met, Glformin, Siofor 1000 ndi ena.

Glucophage (500, 850, 1000), komanso Glucophage 500 ndi 750 ndi mankhwala othandiza a matenda ashuga a 2. Nthawi zambiri, mankhwala omwe amayambitsa mavuto ena amangogwiritsidwa ntchito molakwika. Akagwiritsidwa ntchito moyenera, amakhala ndi thanzi labwino ndipo amachotsa matenda oopsa a matenda ashuga.

Zambiri zokhudzana ndi Glucofage zimaperekedwa mu kanema munkhaniyi.

Tulutsani mitundu ndi ma fanizo

Mu 2017, Glucophage imagulitsidwa ngati mapiritsi oyera a biconvex ozungulira ndi mulingo wa zinthu zomwe zimagwira (metformin hydrochloride): 500, 850 ndi 1000 mg. Amadzaza zidutswa 10 chilichonse m'matumba, pomwe 10, 15 kapena 20 akhoza kukhala mu katoni imodzi. Alumali moyo wa mankhwalawa ndi zaka 3, kutentha kosaloledwa kovomerezeka ndi 15 ° -25 ° C.

Mankhwala, mutha kupeza Glucofage Long - mtundu wa mankhwala omwe ali ndi mphamvu yayitali (yayitali). Mlingo wa metformin mmenemo ndi 500 mg, ndipo gawo la opezawo ndi sodium carmellose, magnesium stearate, hypromellose 2208 ndi 2910, komanso cellcrystalline cellulose. Zomwe zimapangidwira zimathandizira kuti ziwalo zogaya chakudya zimatenga nthawi yochulukirapo kuti zimveke zomwe zimagwira, zomwe zikutanthauza kuti zidzakhala zokwanira komanso zochepa zomwe zingatenge.

Mwa zina za Glucophage analogues, otchuka kwambiri ndi:

Ndi mankhwala ati oti musankhe? Ngati tikuwona mankhwalawa ngati mankhwala a hypoglycemic, ndiye kuti lingaliro lomaliza lidzakhala kwa adotolo. Ngati zotsatira za kuchepetsa thupi zili patsogolo, ndiye kuti ndibwino kuti musankhe, kuyambira pazotsatira zochepa zoyipa za mankhwalawo komanso kuuma kwawo.

Ngakhale kuphatikiza kwa kukonzekera kwa analog kuli pafupifupi kofanana (metformin imayambitsa kuchepa kwa mphamvu zonsezo), zokutira zingapo za shuga, utoto, ndi zina zothandizira (zomwe sizimagwira gawo lofunikira monga zowonjezera) zimatha kukhala ndi magawo osiyanasiyana a kuyeretsa, motero zotsatira zina zoyipa.

Mfundo yogwira ntchito

Glucophage amatanthauza mankhwala a hypoglycemic. Chifukwa cha kapangidwe kake Metformin, mankhwalawa amachepetsa chiwonetsero cha hyperglycemia m'thupi, osathandizira pakukula kwa hypoglycemia.

• imakhazikitsa kagayidwe ka lipid pochepetsa milingo ya triglycerides, cholesterol yathunthu ndi LDL (lipensens lipotroteins),
• zimawonjezera kukhudzika kwa zotumphukira zolandilira kumankhwala angapo achire (mwachitsanzo, insulin),
• imalimbitsa maselo a minyewa kuti ayambe kutulutsa shuga,
• Amachepetsa mayamwidwe am'mimba ndi matumbo ndi gluconeogenesis omwe amachitika m'chiwindi.

Ichi ndi mankhwala othandiziridwa. Chifukwa chake, adokotala ndi adotolo ayenera kudziwa kuchuluka kwa mankhwalawo komanso njira yomwe ili yoyenera kwa thupi lanu. Kudziimira pawokha pazinthu izi kuli ndi zowawa kwambiri (mpaka imfa).

Malangizo apadera omwe angagwiritsidwe ntchito pa matenda ashuga ndi awa:

1. Mankhwalawa amaloledwa kumwa, onse osakanikirana ndi mankhwala ena, popanda kudziyimira pawokha.
2. Kumwa glucophage ndikwabwino kwambiri pakudya, kumwa madzi ambiri owiritsa osakhala ndi mpweya wozizira kwambiri.
3. Kuchepetsa chiopsezo cha zotsatira zoyipa ndikufulumizitsa njira yogwiritsa ntchito mankhwala am'mimba kuti apatsidwe mankhwala, kuwonjezereka kwa mlingo kuyenera kuchitidwa mwadongosolo. Kumayambiriro kwa maphunzirowa munthu wamkulu, mlingo (nthawi imodzi) sayenera kupitirira 500 mg.
4. Tsiku lililonse, wodwalayo ayenera kumwa pafupifupi 1,500 mpaka 2,000 mg wa mankhwalawo. Mulingo wovomerezeka tsiku lililonse ndi 3000 mg.
5. Kuti tikwaniritse kuchuluka kwa glucose m'magazi, ndikofunikira kuphatikiza glucophage ndi insulin.
6. Odwala omwe ndi okalamba kapena sanakwanitse kukhala achikulire, sizikulimbikitsidwa kumwa mankhwalawo. Komabe, ngati kufunikira kotereku kunabuka, ndikofunikira kuyang'aniridwa kwambiri ndi ntchito ya impso ndi serum creatinine.

Tikukumbutsani kuti Glucophage ndi mankhwala amphamvu, chifukwa chake kufunikira koyambirira ndi dokotala ndikofunikira!

Zizindikiro zogwiritsidwa ntchito

Monga tikudziwa kale, Poyamba, Glucophage si piritsi la kudya ayi, koma mankhwala osokoneza bongo a hypoglycemic. Perekani izi, monga lamulo, kwa iwo omwe ayenera kutsika shuga m'magazi:

• lembani 1 ndikulemba odwala 2 a shuga,
• anthu omwe ali ndi kunenepa kwambiri omwe samathandizidwa ndi zochitika zolimbitsa thupi kapena zakudya,
• omwe amamwa insulin kapena mankhwala ena amkamwa a hypoglycemic, koma salandila okwanira kuchokera kwa iwo.

Nthawi zina, mankhwala okhala ndi metformin akuyesera kuti awasinthe ndi ma analogues omwe amakhala ndi mphamvu yocheperako, komanso zakudya zamagulu osiyanasiyana komanso zowonjezera pazitsamba. Zotsatira zabwino zomwe amagwiritsa ntchito ndizofanana, koma kuwonongeka kwa thanzi kumacheperachepera.

Momwe mungadziwire komanso zomwe muyenera kuchita?

Ngakhale mankhwalawa amaperekedwa mosamalitsa malinga ndi zomwe wapangidwira, anthu ena (chifukwa cha opanga mankhwala osavomerezeka) amatha kugula popanda mankhwala. Zikatero, regimen imakokedwa ndi wodwalayo ndipo, monga lamulo, sizikugwirizana ndi zosowa kapena kuthekera kwa thupi. Zotsatira zamachitidwe oterewa nthawi zambiri zimakhala mankhwala osokoneza bongo, omwe amakhala ndi zotsatirazi:

• kusowa kwamadzi (kusowa kwamadzi),
• mseru, kusanza ndi kutsegula m'mimba,
• kupumira msanga, kutentha thupi, matenda obvutika,
• maonekedwe a ululu m'mimba ndi minofu.

Mukapanda kuchita zinthu zofunikira, kuchepa kwa thupi kumayambitsa ngozi ya lactic acidosis, hyperlactacidemic coma, hypoglycemia (osowa kwambiri), ngakhale kufa. Zingothandiza pamenepa:

• kukana kwathunthu kwa Glucophage panthawi yowonetsera zizindikiritso zoyambirira za kuwonongeka kwa moyo wabwino,
• kuchipatala mwachangu ndikuwonetsetsa magazi ake ali lactate,
• hemodialysis ndi symptomatic mankhwala.

Simuyenera kuchita kuyembekezera kuti malangizo ogwiritsira ntchito angakuthandizeni kupanga maphunzirowa. Komabe, adapangira anthu omwe akulimbana ndi matendawa, osati mapaundi owonjezera ndi masentimita.

Zotsatira zoyipa

Ngakhale mutamwa Glucofage molondola, sichikutetezani ku zotsatira zoyipa. Ndipo iwo, ziyenera kudziwika, mankhwalawa ndi akulu kwambiri. Chifukwa chake, m'masiku angapo - masiku atatu mutangoyamba kumene kumwa mumatha kupeza zovuta pantchito:

1. Matumbo oyenda. Kutsekemera kwazitsulo kumawoneka mkamwa, flatulence (kupanga mpweya wambiri) kudzayamba, kukoka kupweteka pamimba kumachitika. Kulakalaka kumatha pang'ono kapena kutha, ndipo malingaliro akumva angasinthe.
2. Chitetezo cha mthupi. Kumwedwa kwa vitamini B12 kumangokulira, ndipo zotsatira zake, hypovitaminosis imayamba ndipo pakhungu lake lingaonekere pakhungu. Milandu ya kusokonezeka kwa metabolic komanso mawonekedwe a lactic acidosis sizachilendo.
3. Mtima wamtima. Milandu yowonongeka kwa magazi ndi kuchepa kwa magazi m'thupi la megaloblastic zalembedwa.
4. Ziwalo zina zamkati. Nthawi zambiri pamakhala kuwonongeka kwa chiwindi, kusowa kwathunthu kwa chidwi cha wodwalayo, kupezeka kwa hepatitis ya mankhwala.

Zowonetsera zambiri izi ndizakanthawi ndipo zimazimiririka sabata yoyamba pambuyo pa kuyamba kwa mabungwe. Komabe, popeza mulibe mankhwala enieni a vutoli, ndikofunikira kuyang'anira thanzi lanu mwachidwi.Ndipo ngati patatha masiku 7 zizindikirazo zikukula kwambiri, kapena mavuto ena omwe sanatchulidwe pamwambapa, muyenera kufunsa dokotala.

Kodi pali zotsatira?

Chinthu chachikulu chomwe chimakondweretsa wodwala aliyense, ndizotsatira zomaliza. Kuti muone kuyipa kwa mankhwalawa, mutha kuyang'ana ku mabwalo azachipatala ndi malo omwe anthu omwe amamwa kale amagawana zomwe akumana nazo. Kuziwerenga, zikuwonekeratu kuti mankhwalawa azitha kukhala othandizira odwala matenda ashuga komanso anthu omwe kunenepa kwambiri kuposa koyambirira, ndipo BMI yafika pa 30 kg / m² kapena kupitirira apo.

Iwo omwe akufuna kugwiritsa ntchito "mapiritsi a zozizwitsawa" kuti athandize kuwonda (mwachitsanzo, kudzipanga dongosolo lisanafike nthawi yamakampani) ayenera kusiya ntchito zawo, chifukwa pamodzi ndi kulemera kwawo amatha kutaya gawo lalikulu laumoyo wawo.

Kodi Glucophage ingaperekedwe kwa ana?

Ngati ndemanga za ogwiritsa ntchito zimakopedwa komanso kukondera, ziwerengero zamankhwala zimangotengera zotsatira za zoyesa zosiyanasiyana komanso mayeso amapereka chidziwitso chomveka bwino pafunso lomwe layankhidwa. Chifukwa chake, makamaka, asayansi ochokera ku Yunivesite ya Oregon adayesa mayeso azachipatala mu 2014, momwe adawunikira momwe kuli koyenera kugwiritsa ntchito Glucofage ndi mankhwala ena angapo a metformin pochiza kunenepa kwambiri kwa ana ndi achinyamata.

Mayesowo anachitika miyezi isanu ndi umodzi. Pafupifupi odwala pafupifupi chikwi azaka zapakati pa 10 mpaka 16 okhala ndi cholozera chachikulu cha 26 mpaka 41 kg / m² ndipo osadwala matenda ashuga adatenga nawo mbali. Nthawi yomweyo, kulolera kwa glucose kunali mkati mwa malire oyenera kwa maphunziro onse.

Zotsatira zakuwonetsa kuti kwa ana, mankhwalawa siothandiza kwenikweni. Kugwiritsa ntchito limodzi ndi ntchito zolimbitsa thupi komanso kuwongolera pakudya sizinali zothandiza kwenikweni kuposa kugwiritsa ntchito njira izi zokha. Zotsatira zabwino zinali kuchepa kwa BMI yamayuniti 1.38, omwe mawu akuti siopitilira 5%.

Kuti mupeze mankhwala omwe ali ndi mndandanda wazotsatira zoyipa, chizindikiro choterocho sichikukhumudwitsa chabe. Ndipo izi zikutanthauza kuti ndibwino kuti musazigwiritse ntchito pakuchepetsa thupi kwa achinyamata achinyamata omwe ali ndi vuto la kunenepa kwambiri koma alibe matenda a shuga.

Zochita Zamankhwala

Mlingo woyenera uli kutali ndi chokhacho chokhacho chomwe chimakhudza kugwira ntchito kwa Glucophage. Ngati muphatikiza kumwa ndi mankhwala ena, zotsatira zake nthawi zambiri zimakhala zosayembekezeka.

1. Kugwiritsa ntchito limodzi ndi mowa komanso mankhwala osokoneza bongo pazambiri zimatha kulephera. Wodwala amapeza woyamba hypoglycemia, kenako amagwa ndi hypoglycemic coma ndipo (pakalibe chithandizo chadzidzidzi) amwalira.
2. Ngati pa nthawi yomwe mumamwa mankhwalawo simumadziletsa pakudya zakudya zamagulu a shuga (mwachitsanzo, shuga kapena maswiti), kuyesa kwanu kuonda kudzakhala ngati kumenyanirana ndi magesi.
3. Ma ayodini okhala ndi ayodini omwe ali ndi radiopaque nawonso sagwirizana. Chifukwa chake, ngati simukufuna kupeza lactic acidosis, muyenera kukana kumwa mankhwalawa masiku 2 asanafike maphunziro a radiology ndi x-ray. Maphunzirowa ayeneranso kuyambitsidwanso pasanathe maola 48 (bola ngati pakuwunika sikunawonekere zozunzika mkati mwa ziwalo zamkati).
4. Zakudya zophatikiza pamodzi ndi kumwa mankhwalawa zimawopseza kuti zingayambitse kusokonezeka kwamphamvu mkati mwa ziwalo zamkati. Panthawi yamankhwala (kuchepa thupi) - thupi liyenera kulandira mchere ndi mavitamini onse ofunikira.

Kuphatikiza kumene kumafunikira kuchenjeza:

1. Ngati mukufuna kuphatikiza kugwiritsa ntchito mankhwalawa ndi ma diuretics ndi mankhwala osokoneza bongo mwachindunji, khalani okonzekera kuti mudzayang'anitsitsa kuchuluka kwa shuga m'magazi mosamala kwambiri komanso nthawi zambiri.
2. Kuphatikizika "Glucophage + loop diuretics" motsutsana ndi kumbuyo kwaimpso kapena kugwira ntchito kwa chiwindi kulephera kukuwopseza kukhala lactic acidosis.
3. Poyesa kuphatikiza ndi insulin, ma salicylates ndi mankhwala a sulfonylurea, wodwalayo wapezeka kale ndi hypoglycemia.
4. Mankhwala a Cationic ndi antihypertensive angapangitse kusintha kwakukulu kwa mankhwala ndi momwe amagwiritsidwira ntchito.
5. Nifedipine, chlorpromazine, ndi angapo a beta 2 - adrenergic agonists amawonjezera kuchuluka kwa shuga m'magazi, chifukwa chake, pamtunda wambiri, amatha kuteteza mphamvu ya mankhwalawa, ndikufuna kuchepetsa, ndikupangitsa insulini.
6. Simuyenera kutenga Glucophage palimodzi, osakambilana kaye ndi dokotala. Ngakhale mankhwalawa ali ndi mfundo zofananira, zotsatira zake kuphatikiza kwawo zimatha kukhala kuwombera kawiri mkati mwa thupi.

Msika wa mankhwalawa ukupita patsogolo kwambiri komanso mwachangu chaka chilichonse. Chifukwa chake, ngati simunapeze mankhwala ena omwe mukutenga pamndandandawu, izi sizitanthauza kuti kugwiritsa ntchito kwawo molumikizana ndi Glucofage sikungakhale ndi zotsatirapo zoyipa. Kuteteza thupi lanu ku ngozi zosafunikira, zonse zimatheka kokha mwa kulumikizana ndi dokotala. Chifukwa chake simudzasokoneza mlingo, ndipo muphunzira za zovuta zamtundu wovuta, zodziwika kokha kwa katswiri wodziwa.

Kusintha kofunikira pakudya

Zakudya mukamatenga Glucofage imafunika. Komanso, muyenera kutsatira izi ngakhale mutamaliza maphunziro a mankhwalawo. Chilimbikitso chokhacho kwa iwo omwe amakonda chakudya chamtengo wapatali ndi chofunda kuposa kusala kapena kudya chakudya.

Mutha kusankha mndandanda woyenera komanso wopanda malire. Poyamba, thupi lidzalandira zonse zofunikira kuchokera ku chakudya, pomwe kuchuluka kwa zopatsa mphamvu kumachepa. Njira yachiwiri imayang'ana pa zakudya zomwe zimakhala ndi chakudya chamagulu ambiri, koma zimachotsa kwathunthu lipids kuzakudya.

M'magawo onse awiriwo, menyu anu ayenera kuphatikizanso zakudya zomwe zimakhala ndi masamba ambiri (nyemba, mbewu, nandolo). Koma zokhudzana ndi shuga ndi zinthu zokhala ndi shuga ndizofunika kuiwaliratu.

Glucophage ndi amodzi mwa mankhwala amphamvu ndipo ali ndi mndandanda waukulu wa zotsutsana ndi zotsatira zoyipa. Chifukwa chake, kumwa iwo ngati njira yochepetsera kunenepa sikuyenera kwa anthu athanzi (omwe alibe zina zina kuposa kukhala onenepa kwambiri). Zotsatira zake zimakhala zakanthawi kochepa, koma zotsatira zake zimakhala zovuta.

Ngati mukufunabe kuchepetsa kulemera pamapiritsi, funsani dokotala wanu ndikuwapempha kuti akulemberereni mitundu kapena alangize othandizira pazakudya zanu. Ndipo siyani mankhwalawa kwa iwo omwe amafunikira.

Kuti mumve chidwi, mankhwala ena omwe amathandizira kuchepetsa thupi:

Munkhaniyi, tikambirana za mankhwala omwe amachepetsa shuga kwa odwala omwe ali ndi matenda a shuga a Glucophage.

"Glucophage" amadziwika kuti biguanides, ndi njira yochepetsera shuga wamagazi, koma sizitsogolera pamikhalidwe ya hypoglycemic. Chomwe chikuchitikira ndikuchepa kwa zomwe zimapangitsa kuti insulin ipange.

Mankhwalawa amapereka zotsatira zake ndikuwonjezera chidwi cha zotumphukira za dongosolo la insulin ndikupanga inshuwaransi ndikuwonjezera minyewa ya shuga. "Glucophage" imathandizanso kupanga shuga m'magazi, imachedwa kuyenda kwa glucose kulowa m'matumbo.

Kuphatikiza apo, mankhwalawa amathandizira kuwonongeka kwa mafuta (lipids).

Chidacho chimatsogolera ku choona chakuti kulemera kwa thupi la wodwalayo kumasiya kuwonjezeka kapena ngakhale kumayamba kuchepa.

Fomu lamasulidwe a Glucofage

• Izi zimapezeka mosiyanasiyana mu mawonekedwe a piritsi, kukhala ndi mtundu wina
• Mapiritsiwo ndi ozungulira kapena ozungulira, amapota. Mlingo 500 mg, 850 mg ndi 100 mg
• Chipangizocho chimalowa mwachangu m'magazi ndikufalikira kudzera m'matumbo, koma osamangira kumapuloteni amwazi. Mankhwalawa amachotsa impso ndipo pafupifupi samaphwanya

Makhalidwe wamba. Zopangidwa:

Mphamvu yogwira: metformin hydrochloride - 500, 850 kapena 1000 mg,
Othandizira: povidone, magnesium stearate.
Filamu wachimvekere:
Mlingo 500 mg ndi 850 mg: hypromellose.
Mlingo wa 1000 mg: opadray yoyera (hypromellose, macrogol 400, macrogol 8000).

Kufotokozera:
Mlingo 500 mg, 850 mg:
Mapiritsi oyera, ozungulira, a biconvex.
Mlingo wa 1000 mg:
Masamba oyera, ozungulira, mapiritsi a biconvex, ophatikizidwa ndi mafilimu, omwe ali pachiwopsezo mbali zonse ziwiri ndipo adalemba "1000" mbali imodzi.
Gawo la mtanda likuwonetsa yunifolomu yoyera.

Mlingo ndi makonzedwe:

Akuluakulu: monotherapy ndi kuphatikiza mankhwalawa kuphatikiza ena othandizira pakamwa:
.Mtundu woyambirira wa mankhwalawa ndi 500 mg katatu pakatha tsiku kapena chakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.
.Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500 - 2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba ndi 3000 mg / tsiku, logawidwa pazidutswa zitatu.
Kuchepetsa pang'ono kwa mankhwalawa kumathandizanso kulolerana kwamatumbo.
.Maphunziro omwe amatenga metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsidwa ku Glucofage® 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg patsiku, womwe umagawidwa pazigawo zitatu.
Pankhani yakukonzekera kusintha kuti mutenge wina wothandizila wa hypoglycemic: muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucofage® pamwambapa womwe wafotokozedwa pamwambapa. Kuphatikiza ndi insulin:
Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza. Mlingo woyamba wa Glucofage® 500 mg ndi 850 mg piritsi limodzi katatu patsiku, Glucofage® 1000 mg - piritsi limodzi nthawi imodzi patsiku, pamene mlingo wa insulin umasankhidwa potengera zotsatira za milingo yamagazi.
.Children ndi achinyamata:
mwa ana kuyambira wazaka 10, Glucofage® ikhoza kugwiritsidwa ntchito limodzi ndi monotherapy komanso kuphatikiza ndi insulin. Mankhwala oyamba mwachangu ndi 500 mg katatu patsiku kapena pakudya. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa kutengera zotsatira za kuyeza magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.
Okalamba okalamba:
chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa powunikira pafupipafupi zizindikiro za ntchito za aimpso (serum creatinine osachepera kawiri mpaka kanayi pachaka).

Zomwe Mungagwiritse Ntchito:

Ngati munthawi ya chithandizo wodwala amakhala ndi ululu wam'mimba, kupweteka kwa minofu, kufooka komanso kukomoka kwambiri, ndikofunikira kusiya kumwa mankhwalawo ndikuwonana ndi dokotala nthawi yomweyo. Zizindikiro izi zitha kukhala chizindikiro cha kulowerera lactic acidosis.
Maola 48 asanafike komanso mkati mwa maola 48 mutatha kafukufuku wa X-ray (urography, intravenous angiography), Glucofage ® iyenera kuyimitsidwa.
Popeza metformin imachotsedwa impso, musanayambe chithandizo komanso pafupipafupi, ndikofunikira kudziwa kuchuluka kwa serum creatinine. Kusamala makamaka kuyenera kuchitika pakakhala vuto la impso, mwachitsanzo, munthawi ya antihypertensive mankhwala kapena mankhwala a diuretic, komanso munthawi ya chithandizo cha NSAIDs.
Wodwalayo ayenera kudziwitsa dokotala za mawonekedwe a matenda a bronchopulmonary kapena matenda opatsirana.
Pa chithandizo, ndikofunikira kupewa kumwa.

Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu
Monotherapy yokhala ndi Glucofage ® siyimayambitsa hypoglycemia chifukwa chake sichikhudza kuyendetsa galimoto ndikugwira ntchito ndi makina.
Komabe, odwala ayenera kusamala pangozi ya hypoglycemia mukamagwiritsa ntchito metformin kuphatikiza mankhwala ena a hypoglycemic (sulfonylureas, insulin, repaglinide, etc.).

Mogwirizana ndi mankhwala ena:

Osavomerezeka kuphatikiza
Kugwiritsa ntchito nthawi yomweyo danazol osavomerezeka kuti apewe hyperglycemic zotsatira za chomaliza. Ngati mankhwala a danazol akufunika ndipo atasiya kuyambiranso, kusintha kwa Glucofage ® kumafunikira motsogozedwa ndi shuga.
Kumwa mowa mwauchidakwa kumawonjezera mwayi wokhala ndi lactic acidosis panthawi yoledzera ya pachimake, makamaka ngati akusala kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera. Mukamwa mankhwalawa, mowa ndi mankhwala okhala ndi Mowa zimayenera kupewedwa.
Kuphatikiza komwe kumafunikira chisamaliro chapadera
Chlorpromazine: akagwiritsidwa ntchito mu milingo yayikulu (100 mg patsiku) amawonjezera glycemia, kuchepetsa kutulutsa kwa insulin. Mankhwala a antipsychotic ndipo atayimitsa kudya kwa chakumapeto, kusintha kwa mlingo wa Glucofage® kumafunika motsogozedwa ndi msana wa glycemia.
Glucocorticosteroids (GCS) yachilengedwe komanso yachilengedwe imachepetsa kulolera kwa glucose, kuonjezera glycemia, nthawi zina kuyambitsa ketosis. Mankhwalawa corticosteroids, ndipo atayimitsa kumwa mankhwala omaliza, kusintha kwa Glucofage® kumafunika motsogozedwa ndi glycemia.
Diuretics: munthawi yomweyo kugwiritsa ntchito malupu okodzetsa kungayambitse kukula kwa lactic acidosis chifukwa chotheka kugwira ntchito kwaimpso. Glucofage ® sayenera kukhazikitsidwa ngati chilolezo cha creatinine chili pansi pa 60 ml / min.
Iodini wokhala ndi ma radiopaque othandizira: kafukufuku wama radiology ogwiritsa ntchito ayodini omwe amakhala ndi radiopaque angayambitse kukula kwa lactic acidosis kwa odwala omwe ali ndi matenda osokoneza bongo omwe amakanika ndi aimpso kulephera. Kukhazikitsidwa kwa Glucofage ® kuyenera kuchotsedwa maola 48 kale ndipo sikumapangidwanso masiku 2 kuchokera pakuwunika kwa X-ray pogwiritsa ntchito ma radiopaque othandizira.
Jekeseni wa beta-2 wothandizika: onjezani glycemia chifukwa cha kukondoweza kwa beta-2 adrenergic receptors. Pankhaniyi, kuyang'anira glycemic ndikofunikira. Ngati ndi kotheka, insulin ikulimbikitsidwa. Tiyenera kukumbukira kuti ACE inhibitors ndi mankhwala ena a antihypertensive amatha kutsitsa shuga. Ngati ndi kotheka, mlingo wa metformin uyenera kusinthidwa.
Ndi munthawi yomweyo kugwiritsa ntchito Glucofage ® ndi sulfonylurea zotumphukira, insulin, acarbose, salicylates, kuchuluka kwa hypoglycemic kumatheka.

Zoyipa:

Hypersensitivity to metformin kapena aliyense wa opezekapo,
Matenda a shuga, matenda a shuga, chikomokere,
Kuwonongeka kwa impso (kulengedwa kwa creatinine zosakwana 60 ml / min)
Matenda owopsa omwe ali ndi chiopsezo chokhala ndi vuto la impso: kuchepa magazi (ndi m'mimba, kusanza), kutentha thupi, matenda opatsirana, mikhalidwe ya hypoxia (mantha, matenda a impso, matenda a bronchopulmonary),
Matenda akufotokozera za matenda owopsa komanso osatha omwe angayambitse kukula kwa minofu hypoxia (mtima kapena kupuma, ndi zina zambiri).
Opaleshoni yayikulu ndikuvulala (pamene chithandizo cha insulin chikusonyezedwa),
Kuwonongeka kwa chiwindi
uchidakwa wambiri, pachimake
Mimba, kuyamwa,
Lactic acidosis (kuphatikizapo mbiri),
ntchito masiku osachepera awiri asanadutse masiku awiri mutachita maphunziro a radioisotope kapena radiology poyambitsa iodini.
Kusungidwa kwa zakudya zama hypocaloric (zosakwana 1000 calories / tsiku),
Sizikulimbikitsidwa kugwiritsa ntchito mankhwalawa mwa anthu opitirira zaka 60 omwe amagwira ntchito zolimbitsa thupi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa
Pokonzekera kutenga pakati, komanso pathupi panu mukumwa Metformin, mankhwalawa ayenera kusiyidwa, ndipo mankhwala a insulin ayenera kuyikidwa. Kunyina nobayanda kubbapatizyigwa. Popeza palibe chidziwitso pakulowera mkaka wa m'mawere, mankhwalawa amatsutsana pakuyamwa.
Ngati ndi kotheka, kugwiritsa ntchito metformin panthawi yoyamwitsa kuyenera kutha.

Malo opumulira:

500 mg mapiritsi okhala ndi mafilimu:
Mapiritsi 10 pachimake cha PVC / aluminium zojambulazo, matuza 3 kapena 5 okhala ndi malangizo ogwiritsira ntchito amayikidwa mu katoni, mapiritsi 15 ali ndi matuza a PVC / aluminium zojambulazo, matuza awiri okhala ndi malangizo ogwiritsira ntchito amayikidwa pabokosi la makatoni,
Mapiritsi okhala ndi mafilimu 850 mg:
Mapiritsi 15 mu chithuza cha PVC / aluminium zojambulazo, matuza awiri pamodzi ndi malangizo ogwiritsira ntchito aikidwa m'bokosi lamatoni,
Mapiritsi 20 pachimake cha PVC / aluminium zojambulazo, matuza atatu kapena 5 limodzi ndi malangizo ogwiritsira ntchito amayikidwa mu katoni.
Mapiritsi okwana 1000 mg okhala ndi mafilimu
Mapiritsi 10 pachimake cha PVC / aluminium zojambulazo, matuza 3, 5, 6 kapena 12, pamodzi ndi malangizo ogwiritsira ntchito, aikidwa pabokosi la makatoni,
Mapiritsi 15 pa chithuza cha PVC / aluminium zojambulazo, matuza 2, 3 kapena 4, pamodzi ndi malangizo ogwiritsira ntchito, amaikidwa pabokosi lamatoni.

Mankhwala oyambirira a metformin omwe amakwaniritsa mfundo zonse zamankhwala zokhala ndi umboni

Mlingo

Mlingo 500 mg, 850 mg:
Mapiritsi oyera, ozungulira, a biconvex.

Mlingo wa 1000 mg:
Masamba oyera, ozungulira, mapiritsi a biconvex, ophatikizidwa ndi mafilimu, omwe ali pachiwopsezo mbali zonse ziwiri ndipo adalemba "1000" mbali imodzi.
Gawo la mtanda likuwonetsa yunifolomu yoyera.

Pharmacotherapeutic katundu

Metformin imachepetsa hyperglycemia popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zomwe zimachokera ku sulfonylurea, sizimalimbikitsa insulin komanso sizikhala ndi vuto pakati pa anthu athanzi. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis.
Kuchepetsa mayamwidwe m'matumbo.

Metformin imalimbikitsa kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yathunthu, lipoproteins yotsika komanso triglycerides.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Kafukufuku wachipatala awonetsanso kugwira bwino ntchito kwa mankhwalawa Glucofage ® popewa matenda ashuga odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa mtundu wachiwiri wa matenda ashuga, momwe kusintha kwasinthidwe sikunalole kuti chiwonetsero chokwanira cha glycemic chikwaniritsidwe.

Madzi ndi kugawa
Pambuyo pakukonzekera pakamwa, metformin imatengedwa kuchokera kumimba kwathunthu. Mtheradi bioavailability ndi 50-60%. Kuchuluka kwa ndende (Cmax) (pafupifupi 2 μg / ml kapena 15 μmol) m'madzi a plasma kumachitika pambuyo pa maola 2,5. Kugawa chakudya munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma.

Kutetemera ndi chimbudzi
Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuvomerezeka kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa kutulutsa chilolezo cha creatinine), zomwe zikuwonetsa kukhalapo kwa secalic secretion. Hafu ya moyo ndi pafupifupi maola 6.5.Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kukopeka kwa mankhwalawa.

Kupanga ndi mawonekedwe a kumasulidwa

Gulu la zamankhwala ndi mankhwala: pakamwa hypoglycemic mankhwala.

• Mphamvu yogwira: metformin hydrochloride - 500, 850 kapena 1000 mg,
• Othandizira: povidone, magnesium stearate.

Mlingo wa 500 mg, 850 mg: oyera, ozungulira, mapiritsi a biconvex, filimu yokutira. Gawo la mtanda likuwonetsa yunifolomu yoyera.

Pharmacology

Oral hypoglycemic mankhwala ochokera pagulu la Biguanide.

Glucophage ® imachepetsa hyperglycemia, popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi.

Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis. Kuchepetsa mayamwidwe m'matumbo.

Metformin imalimbikitsa kapangidwe ka glycogen pochita glycogen synthetase. Kuchulukitsa kuchuluka kwa mayendedwe amtundu uliwonse wa ma membrane glucose.

Kuphatikiza apo, ili ndi phindu pa metabolidi ya lipid: imatsitsa cholesterol yathunthu, LDL ndi TG.

Ngakhale mutamwa metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Pharmacokinetics

Mutatha kumwa mankhwalawo mkati, metformin imatenga gawo lonse la chakudya. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Mtheradi bioavailability ndi 50-60%. C max mu plasma pafupifupi 2 μg / ml kapena 15 μmol ndipo umatheka pambuyo maola 2,5.

Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma.

Amachepetsa pang'ono ndi kupukusidwa ndi impso.

Kuvomerezeka kwa metformin mwa anthu athanzi ndi 400 ml / min (kanthawi kuposa KK), komwe kumawonetsa katulutsidwe ka tubular.

T 1/2 pafupifupi maola 6.5

Pharmacokinetics mu milandu yapadera yamankhwala

Odwala omwe amalephera kupezeka ndi aimpso, T 1/2 amachulukirapo, pamakhala chiopsezo cha kuchuluka kwa metformin mthupi.

Kutulutsa Fomu

Mapiritsi, oyera-okutira oyera, ozungulira, biconvex, pamtanda - gulu loyera loyera.

Omwe amathandizira: povidone - 20 mg, magnesium stearate - 5.0 mg.

Zomwe zimapangidwa ndi nembanemba wa filimu: hypromellose - 4.0 mg.

Ma PC 10 - matuza (3) - mapaketi a makatoni.
Ma PC 10 - matuza (5) - mapaketi a makatoni.
15 ma PC. - matuza (2) - mapaketi a makatoni.
15 ma PC. - matuza (4) - mapaketi a makatoni.
20 ma PC. - matuza (3) - mapaketi a makatoni.
20 ma PC. - matuza (5) - mapaketi a makatoni.

Mankhwala amatengedwa pakamwa.

Monotherapy ndi kuphatikiza mankhwalawa ndi ena othandizira pakamwa

Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 2-3 nthawi / tsiku mutadya kapena pakudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba kwambiri ndi 3000 mg / tsiku, wogawidwa mu 3 waukulu.

Kuchepetsa pang'ono kwa mankhwalawa kungathandize kusintha kulolerana kwa m'mimba.

Odwala omwe amalandila metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsidwa ku mankhwala Glucofage ® 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Ngati mukufuna kusintha kuti mumwe mankhwala ena a hypoglycemic, muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucofage ® mu mlingo womwe tafotokozawu.

Kuphatikiza kwa insulin

Kukwaniritsa bwino shuga wamagazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala ophatikiza.Mlingo woyamba wa Glucofage ® ndi 500 mg kapena 850 mg katatu / tsiku, pomwe mlingo wa insulin umasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ana ndi achinyamata

Odwala okalamba

Chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa zomwe zili serum creatinine osachepera 2-4 pachaka).

Glucofage ® iyenera kumwedwa tsiku lililonse, osasokoneza. Ngati chithandizo chalekeka, wodwalayo ayenera kudziwitsa dokotala.

Glucophage. Contraindication

• Kukhalapo kwa hypersensitivity kumodzi yogwira kapena zingapo zowonjezera za mankhwala.
• Kuwonongeka kwa kagayidwe kazakudya m'thupi, limodzi ndi kufooka kwambiri, ludzu losatha, kukoka pafupipafupi (kuphatikizapo precoma ndi chikomokere mu matenda ashuga, kupezeka kwa ketoacidosis, kukhazikitsidwa chifukwa cha mayeso a labotale).
• Zizindikiro za ntchito aimpso kuwonongeka kapena aimpso kulephera.
• Zizindikiro zake zazikuluzikulu zaimpso ntchito.
• Kuchepetsa kwakukulu kuchuluka kwa madzi mthupi (Zizindikiro - kutsegula m'mimba, kusanza, ndi zina).
• Matenda opatsirana.
• Matenda owopsa a mtima, kuphatikizira kwamtima m'matumbo oyambira.
• The pachimake ndi matenda mawonekedwe (monga chiopsezo cha hypoxia).
• Kulephera kopindulitsa.
• Kwambiri lactic acidosis mu odwala matenda ashuga, kuphatikizapo mbiri, pamene lactic acid yambiri ilowa m'magazi poyerekeza ndi kuchuluka komwe kuchotsedwa m'thupi.
• Nthawi yoperekera opaleshoni (kuphatikizapo opaleshoni yovulala makina).
• Hepatic kulephera kapena ntchito chiwindi.
• Poizoni wa Ethanoli.
• Mowa
• Akazi - munthawi ya bere.
• Zizindikiro za lactic acidosis (Zizindikiro - kutsegula m'mimba, kusanza, kusanza, kupweteka pamimba.
• Kuchepa kwakukulu kwa insulin mthupi.
• Masiku angapo kusanachitike kupimidwa kwa x-ray ndi masiku angapo pambuyo pake.
• Gwiritsani ntchito zakudya zochepa zopatsa mphamvu (zopatsa mphamvu za calorie - zosakwana kcal chikwi patsiku).

Zindikirani Chenjezo makamaka mukamamwa mankhwalawa liyenera kuonedwa:

• kwa odwala okalamba, kuyambira zaka makumi asanu ndi limodzi,
• anthu ogwira ntchito zolimba,
• ndi kulephera kwa chiwindi (mawonekedwe a kuvomerezera kwa kupanga kwa mamililita 45 mpaka 59 pa mphindi).
• azimayi oyamwitsa.

Glucophage. Mlingo

Mapiritsi oyendetsera pakamwa (pakamwa).

Amagwiritsidwa ntchito ngati monotherapy kapena mankhwala ophatikiza (poika ena othandizira a hypoglycemic).

Gawo loyamba ndi 500 mg ya mankhwalawo, nthawi zina 850 mg (m'mawa, masana, ndi madzulo pamimba yonse.

M'tsogolomu, mlingo umakulitsidwa (monga momwe amafunikira komanso pokhapokha mukaonana ndi dokotala).

Kuti mukhalebe achire mothandizidwa ndi mankhwalawa, tsiku lililonse mlingo umafunikira - kuyambira 1500 mpaka 2000 mg. Mlingo woletsedwa kupitirira 3000 mg ndi kupitilira!

Kuchuluka kwa tsiku ndi tsiku kumagawika katatu kapena kanayi, komwe ndikofunikira kuti muchepetse zovuta.

Zindikirani Ndikofunikira kuwonjezera mlingo wa tsiku ndi tsiku kwa sabata, pang'onopang'ono, kuti mupewe zoipa. Kwa odwala omwe adamwa kale mankhwala ophatikizika ndi Metformin ochulukirapo kuyambira 2000 mpaka 3000 mg, mapiritsi a Glucofage ayenera kumwedwa pa mlingo wa 1000 mg patsiku.

Ngati mukufuna kukana kumwa mankhwalawa omwe amakhudza mafupa a hypoglycemic, muyenera kuyamba kumwa mapiritsi a Glucofage muyezo wochepetsedwa, momwe mungapangire monotherapy.

Glucophage ndi insulin

Ngati mukufunikira insulin yowonjezera, yotsirizayo imagwiritsidwa ntchito kokha pa mlingo womwe adotolo adatenga.

Mankhwala othandizira omwe ali ndi metamorphine ndi insulin amafunikira kuti akwaniritse kuchuluka kwa shuga m'magazi.Algorithm yokhazikika ndi piritsi ya 500 mg (nthawi zambiri imakhala 850 mg) kawiri kapena katatu patsiku.

Mlingo wa ana ndi achinyamata

Kuyambira azaka khumi ndi akulu - ngati mankhwala odziyimira pawokha, kapena ngati gawo limodzi la mankhwala (pamodzi ndi insulin).

Mlingo woyenera (woyamba) wosakwatiwa tsiku lililonse ndi piritsi limodzi (500 kapena 850 mg.), Lomwe limatengedwa ndi zakudya. Amaloledwa kumwa mankhwalawa kwa theka la ola mutatha kudya.

Kutengera kuchuluka kwa shuga m'magazi, mlingo wa mankhwalawo umasinthidwa pang'onopang'ono (mizere - osachepera sabata imodzi kapena ziwiri). Mlingo wa ana waletsedwa kuchuluka (kupitirira 2000 mg). Mankhwalawa agawidwe m'magawo atatu, osachepera awiri.

Kuphatikiza komwe sikuloledwa mwanjira iliyonse

Othandizira kusiyanitsa ndi X-ray (okhala ndi ayodini). Kuunika kwa radiology kumatha kukhala chothandizira pakukula kwa lactic acidosis kwa wodwala yemwe ali ndi matenda a shuga.

Glucophage amasiya kutengedwa masiku atatu kafukufukuyu asanatenge masiku atatu pambuyo pake (kwathunthu, sabata limodzi ndi tsiku la phunziroli). Ngati ntchito yaimpso molingana ndi zotsatira zake sizinakhutire, nthawi imeneyi imawonjezeka - mpaka thupi litabwezeretseka kwathunthu.

Chingakhale chanzeru kukana kugwiritsa ntchito mankhwalawa ngati pali kuchuluka kwa ethanol mthupi (kuledzera kwakumwa). Kuphatikiza uku kumayambitsa mapangidwe a machitidwe kuti awonetsere zizindikiro za lactic acidosis. Zakudya zama calorie otsika kapena vuto la kuperewera kwa zakudya m'thupi, makamaka motsutsana ndi maziko a kulephera kwa chiwindi, zimawonjezera ngoziyi.

Pomaliza Ngati wodwala amwa mankhwalawa, ayenera kusiyiratu kumwa mowa uliwonse, kuphatikizapo mankhwala omwe amaphatikizapo ethanol.

Kuphatikiza komwe kumafuna kusamala

Danazole Kugwiritsa ntchito nthawi yomweyo kwa Glucofage ndi Danazole sikofunikira. Danazole ndi wowopsa ndi hyperglycemic effect. Ngati ndizosatheka kukana pazifukwa zosiyanasiyana, kusintha kwapadera kwa Glucofage ndikuwunika pafupipafupi kuchuluka kwamagazi pamafunika.

Chlorpromazine mu mlingo waukulu wa tsiku ndi tsiku (woposa 100 mg), womwe umathandiza kuwonjezera kuchuluka kwa shuga m'magazi ndipo umachepetsa mwayi wokhala ndi insulini. Kusintha kwa mlingo kuyenera.

Ma antipsychotic. Chithandizo cha odwala omwe ali ndi antipsychotic chiyenera kuvomerezedwa ndi dokotala. Kusintha kwa mlingo wa Glucofage ndikofunikira malinga ndi kuchuluka kwa shuga m'magazi.

GCS (glucocorticosteroids) imasokoneza kulekerera kwa glucose - kuchuluka kwa glucose m'magazi kumakwera, komwe kungayambitse ketosis. Zikatero, Glucophage imayenera kutengedwa kutengera kuchuluka kwa shuga m'magazi.

Zopitsa za m'mimba mwa loopt zimatengera nthawi yomweyo ndi glucophage zimabweretsa chiopsezo cha lactic acidosis. Ndi CC kuchokera pa 60 ml / mphindi ndi pansi, glucophage sinafotokozedwe.

Adrenomimetics. Mukamamwa ma Beta 2-adrenergic agonists, kuchuluka kwa shuga m'thupi kumawukanso, komwe nthawi zina kumafunanso Mlingo wa insulin wina wodwala.

Ma inhibitors a ACE ndi mankhwala onse a antihypertensive amafuna kusintha kwa mlingo wa metformin.

Sulfonylurea, insulin, acarbose ndi salicylates akaphatikizidwa pamodzi ndi glucophage angayambitse kukula kwa hypoglycemia.

Mimba komanso kuyamwa. Zinthu Zakutha

Glucophage sayenera kumwedwa panthawi yomwe ali ndi pakati.

Matenda akulu a shuga amatha kubadwa kwatsopano kwa mwana wosabadwayo. Pakapita nthawi - umunthu wangozi. Ngati mayi akufuna kubereka kapena ali m'magawo oyamba a kubereka, ndikofunikira kukana kumwa mankhwala Glucofage. M'malo mwake, mankhwala a insulin amadziwika kuti azisunga shuga wambiri.

Kwa odwala. Chidziwitso Chofunikira cha Lacticosis

Lactic acidosis si matenda wamba.Komabe, njira zonse zofunikira ziyenera kuchitidwa kuti athetse chiwonetsero chake, popeza matenda amtunduwu amadziwika ndi zovuta zambiri komanso kufa kwakukulu.

Lactic acidosis nthawi zambiri imawonekera mu odwala omwe amatenga metamorphine omwe anali ndi vuto lalikulu laimpso chifukwa cha matenda a shuga.

Zina zomwe zimayambitsa ngozi ndi izi:

• Zizindikiro za matenda ashuga.
• Mawonekedwe a ketosis.
• Kutalika kwa vuto la kuperewera kwa thupi.
• Magawo owopsa a chidakwa.
• Zizindikiro za hypoxia.

Ndikofunikira. Ndikofunika kulabadira zizindikiro za gawo loyambirira la lactic acidosis. Ichi ndi chizindikiro cha kuwonekera, kuwonekera minofu kukokana, kukomoka, kupweteka kwam'mimba komanso asthenia yayikulu. Acidotic dyspnea ndi hypothermia, ngati zizindikiro isanachitike chikomokere, amasonyezanso matendawa. Zizindikiro zilizonse za metabolic acidosis ndizomwe zimapangitsa kuti mankhwalawo athe kaye komanso kufunafuna chithandizo chamankhwala mwachangu.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Pokonzekera kutenga pakati, komanso pathupi pathupi lomwe limayamwa kutenga metformin ndi prediabetes ndi mtundu 2 shuga, mankhwalawo ayenera kusiyidwa, ndipo ngati matenda amtundu wa 2 matenda a shuga aperekedwa. Ndikofunikira kusungitsa glucose omwe ali m'madzi am'magazi pamlingo woyandikira kwambiri kuti achepetse vuto la fetus.

Metformin imadutsa mkaka wa m'mawere. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke. Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa sikulimbikitsidwa. Lingaliro loletsa kuyamwitsa liyenera kuchitika poganizira zabwino za kuyamwitsa ndi chiopsezo cha zovuta zoyambira mwana.

Zotsatira zoyipa

Matenda a Metabolic ndi zakudya:
Osowa kwambiri: lactic acidosis (onani "Malangizo apadera"). Pogwiritsa ntchito metformin kwanthawi yayitali, kuchepa kwa mayamwidwe a vitamini B12 kungawonedwe. Ngati matenda am'madzi a megaloblastic apezeka, mwayi wa etiology wotere uyenera kuganiziridwa.

Kuphwanya kwamanjenje:
Nthawi zambiri: kulawa kusokonezeka.

Matenda am'mimba:
Nthawi zambiri: nseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba komanso kusowa kwa chakudya.
Nthawi zambiri zimachitika nthawi yoyamba ya chithandizo ndipo nthawi zambiri zimadutsa zokha. Popewa Zizindikiro, tikulimbikitsidwa kuti muzimwa metformin 2 kapena 3 pa tsiku nthawi yakudya kapena itatha. Kuchepetsa pang'ono kwa mankhwalawa kumathandizira kulolerana kwamatumbo.

Zovuta za pakhungu ndi minofu yolowera:
Osowa kwambiri: zimachitika pakhungu monga erythema, pruritus, zidzolo.

Kuphwanya chiwindi ndi chindapusa:
Osowa kwambiri: kuwonongeka kwa chiwindi ndi hepatitis, atatha kufooka kwa metformin, izi zosafunikira zimatha.

Zambiri zosindikizidwa, zotsatsa zam'mbuyo, komanso maphunziro azachipatala owerengeka mwa ana ochepera zaka 10-16 akuwonetsa kuti zotsatila za ana zimafanana mu chilengedwe komanso kuopsa kwa odwala.

Malangizo apadera

Zina zokhudzana ndi chiopsezo ziyenera kuganiziridwanso, monga matenda a shuga ochititsa chidwi, ketosis, kusala kudya kwa nthawi yayitali, uchidakwa, kulephera kwa chiwindi ndi vuto lililonse lomwe lingakhale ndi hypoxia yayikulu. Izi zitha kuthandiza kuchepetsa zochitika za lactic acidosis.

Muyenera kuganizira za chiopsezo cha lactic acidosis ndi mawonekedwe a zosakhazikika, monga kukokana kwa minofu, limodzi ndi vuto la dyspeptic, kupweteka kwam'mimba komanso asthenia yayikulu. Lactic acidosis imadziwika ndi kufupika kwa acidotic, kupweteka kwam'mimba komanso hypothermia yotsatiridwa ndi chikomokere.Diagnostic labotale magawo ndi kuchepa kwa magazi pH (osachepera 7.25), lactate zili mu plasma yoposa 5 mmol / l, kuchuluka kwa anion ndi mulingo wa lactate / pyruvate. Ngati metabolic acidosis ikukayikira, ndikofunikira kusiya kumwa mankhwalawo ndikuwonana ndi dokotala nthawi yomweyo.

Opaleshoni
Kugwiritsa ntchito metformin kuyenera kusiyidwa kwa maola 48 kusanachitike opaleshoni yomwe ikukonzedwa ndipo kutha kupitiliridwanso osapitilira maola 48 zitatha, pokhapokha pakuwunikira ntchito ya impso idadziwika kuti ndiyabwino.

Impso
Popeza metformin imachotsedwa impso, isanayambe chithandizo komanso nthawi zambiri pambuyo pake, kuvomerezedwa kwa creatinine kuyenera kutsimikiziridwa:

• osachepera kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso,
• osachepera 2-4 pachaka odwala okalamba, komanso odwala omwe amapezeka ndi creatinine chilolezo chotsika.

Ngati creatine chilolezo zosakwana 45 ml / min, kugwiritsa ntchito mankhwalawa ndi zotsutsana.
Kusamalidwa kwapadera kuyenera kuthandizidwa makamaka ngati odwala omwe ali ndi vuto laimpso amatha kugwiritsa ntchito mankhwala omwe ali ndi antihypertensive, okodzetsa kapena osapweteka a antiidal.

Kulephera kwa mtima
Odwala omwe ali ndi vuto la mtima ali ndi chiopsezo chachikulu chokhala ndi hypoxia komanso kulephera kwa impso. Odwala omwe ali ndi vuto la mtima akudwala ayenera kuyang'anira ntchito ya mtima ndi impso akamamwa metformin. Metformin yolephera pamtima ndi hemodynamics yosakhazikika imatsutsana.

Ana ndi achinyamata
Kuzindikiritsidwa kwa matenda a shuga a 2 kuyenera kutsimikiziridwa musanayambe chithandizo ndi metformin. M'mayeso azachipatala omwe amakhala chaka chimodzi, adawonetsedwa kuti metformin sikukhudza kukula ndi kutha msinkhu. Komabe, chifukwa cha kuchepa kwa nthawi yayitali, kuwunikira mosamala za zotsatira za metformin pama paramu amenewa mwa ana, makamaka pa nthawi yakutha, ndikulimbikitsidwa. Kuwunikira kosamala kwambiri ndikofunikira kwa ana azaka za 10-12.

Chenjezo lina:

• Odwala akulangizidwa kuti apitirize kudya zakudya zokhala ndi chakudya chamafuta tsiku lonse. Odwala onenepa kwambiri amalangizidwa kuti azitsatira zakudya zama hypocaloric (koma osachepera 1000 kcal / tsiku).
• Ndikulimbikitsidwa kuti kuyesedwa kwa ma labotale nthawi zonse kuchitidwe kuyang'anira matenda ashuga.
• Metformin siyimayambitsa hypoglycemia pa nthawi ya monotherapy, koma kusamala kumalangizidwa mukamagwiritsidwa ntchito ndi insulin kapena othandizira ena a hypoglycemic (mwachitsanzo, sulfonylureas, repaglinide, etc.).

Kugwiritsa ntchito mankhwala Glucofage ® ndikulimbikitsidwa kupewa matenda a shuga 2 mwa anthu omwe ali ndi prediabetes ndi zina zowonjezera chiopsezo cha chitukuko cha mtundu wachiwiri wa matenda a shuga monga:
- zaka zosakwana 60,
- index of body (BMI) ≥35 kg / m2,
- mbiri ya matenda ashuga,
- mbiri ya mabanja a matenda ashuga a achibale a digiri yoyamba,
- kuchuluka ndende ya triglycerides,
- kuchepa kwa ndende ya HDL cholesterol,

Zokhudza mphamvu pakutha kuyendetsa magalimoto ndi zida

Monotherapy yokhala ndi Glucofage ® siyimayambitsa hypoglycemia, chifukwa chake, sizikhudza kuthekera koyendetsa magalimoto ndi machitidwe.
Komabe, odwala ayenera kuchenjezedwa za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin limodzi ndi mankhwala ena a hypoglycemic (zotumphukira za sulfonylurea, insulin, repaglinide, etc.).

Kodi Glucophage amagwiritsidwa ntchito chifukwa chiyani?

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:

• Akuluakulu, monga monotherapy kapena kuphatikiza ndi ena othandizira pakamwa, kapena ndi insulin,
• mwa ana kuyambira azaka 10 monga monotherapy kapena osakaniza insulin.

Zotsatira za pharmacological

Kupanga kwamatenda a Glucophage ndiko kutha kwa mankhwalawo kuletsa glycogenolysis ndi gluconeogeneis, kuchepetsa kuyamwa kwa glucose m'matumbo am'mimba, komanso kumawonjezera chidwi cha thupi ku insulin. Komanso, yogwira mankhwala zimabweretsa kusintha kagayidwe kachakudya mafuta, otsika kachulukidwe lipoproteins ndi cholesterol kulowa thupi lathu.

Gawo lalikulu la mankhwala lomwe limafunsidwa ndi metformin, chinthu chodziwika bwino ndi vuto la hypoglycemic, lomwe limayamba pokhapokha wodwala ali ndi hyperglycemia (glucose yayikulu m'magazi a magazi).

Mwanjira ina, metformin imatsitsa kuchuluka kwa glucose m'madzi am'magazi mwa odwala omwe ali ndi hyperglycemia, koma sizikhudza kuchuluka kwa glucose m'magazi mwa anthu omwe ali ndi vuto.

Glucophage pa opareshoni

Ngati wodwala wakonzekera kuchitidwa opaleshoni, metformin iyenera kuthetsedwa masiku atatu lisanachitike tsiku la opareshoni. Kuyambiranso kwa mankhwalawa kumachitika pokhapokha kupenda ntchito yaimpso, ntchito yomwe idapezeka kuti ikukhutiritsa. Pankhaniyi, Glucofage imatha kutengedwa tsiku lachinayi atachitidwa opaleshoni.

Kuyesa kwa impso

Metformin imakumbidwa ndi impso, kotero kuyamba kwa chithandizo kumagwirizanitsidwa nthawi zonse ndi kuyesedwa kwa labotale (kuwerengera kwa creatinine). Kwa iwo omwe ntchito ya impso yake siili ndi vuto, ndizokwanira kuchititsa maphunziro azachipatala kamodzi pachaka. Kwa anthu omwe ali pachiwopsezo, komanso odwala okalamba, kutsimikiza kwa QC (kuchuluka kwa creatinine) kuyenera kuchitidwa kangapo pachaka.

Ngati ma diuretics ndi mankhwala a antihypertensive amaperekedwa kwa anthu okalamba, kuwonongeka kwa impso kumatha kuchitika, zomwe zimangotanthauza kufunikira kokawunika mosamala ndi madokotala.

Glucophage mwa ana

Kwa ana, mankhwalawa amadziwitsidwa pokhapokha ngati mayesowo awatsimikizira pakutsimikizira kwawo.

Maphunziro azachipatala ayeneranso kutsimikizira chitetezo cha mwana (kukula ndi kutha msinkhu). Kuyang'aniridwa kwachipatala pafupipafupi pochiza ana ndi achinyamata kumafunika.

Wopanga

Kapena ngati mutayika mankhwala a LLC Nanolek:

Wopanga
Kupanga kwa mitundu yomaliza ya Mlingo ndi ma CD
Merck Sante SAAS, France
Center de Production Semois, 2 rue du Pressoire Ver - 45400 Semois, France

Chachiwiri (ma CD a ogula) ndikupereka mawonekedwe oyang'anira:
Nanolek LLC, Russia
612079, dera la Kirov, chigawo cha Orichevsky, tawuni ya Levintsy, Biomedical complex "NANOLEK"

Wopanga
Magawo onse opanga, kuphatikiza kuwongolera khalidwe:
Merck S. L., Spain
Polygon Merck, 08100 Mollet Del Valles, Barcelona, ​​Spain.

Zodandaula za ogula ziyenera kutumizidwa kwa:
LLC "Merk"
115054 Moscow, st. Zokwanira, d. 35.

Anthu ambiri onenepa kwambiri safuna kapena kutaya nthawi yambiri pamasewera, osasintha momwe amadyera. Izi zimatipangitsa kufunafuna njira yachipatala yothetsera vutoli.

Mitundu yonse yazitsamba zozizwitsa za ku China idakhumudwitsa kale, chifukwa chake anthu adaganiza kuti atchere khutu ku mankhwala ovomerezeka, mbali zoyipa zake zomwe ndi kuwonda.

Mankhwala otchuka kwambiri pazolinga izi anali Glucofage.

Kodi ndi chiyani komanso momwe mungagwiritsire ntchito?

Njira zopewera kupewa ngozi

Kukhazikitsidwa kwa zakudya komwe zakudya zimayenera kudyedwa zokwanira komanso moyenera.

Ngati ndinu onenepa kwambiri, mutha kupitiliza kudya kwa hypocaloric, koma pokhapokha pazoyambira 1000 - 1500 kcal tsiku lililonse.

Ndikofunikira. Kuyeserera pafupipafupi kwa maulamuliro kuyenera kukhala lamulo lovomerezeka kwa onse omwe amamwa mankhwalawa Glucofage.

Kufotokozera kwapfupi

Mankhwala amapezeka mu mawonekedwe a mapiritsi ophimbidwa ndi kuphatikiza kwapadera chifukwa chofuna kukhazikitsa. Pali milingo ingapo yayikulu yogwiritsira ntchito - metformin. Mwakutero, ma milligram 500, 850 ndi chikwi.

Madokotala amapereka mankhwala kwa odwala matenda ashuga omwe ali ndi matenda amtundu wachiwiri. Cholinga ndikuchepetsa kuchuluka kwa insulin. Dzinali lingasiyane, kutengera wopanga, koma chinthu chachikulu ndikuwona zomwe zimagwira.

Contraindication ndi zoyipa

Mankhwalawa ali ndi zotsutsana zingapo zogwiritsidwa ntchito, chifukwa musanayambe kumwa Glucofage kuti muchepetse thupi, muyenera kuwerenga mndandandawu mosamala.

Sizoletsedwa kumwa mapiritsi a anthu odwala:

• mtundu 1 shuga
• Matenda a mtundu wachiwiri, womwe insulin yake siyipangidwa.
• Kulephera kwaimpso kapena matenda ena akuluakulu a impso,
• chiwindi ntchito,
• matenda akulu a mtima dongosolo.

• uchidakwa
• kanthawi kochepa atachitidwa opaleshoni kapena matenda opatsirana,
• Oletsedwa mwamphamvu kwa amayi apakati ndi oyamwitsa,
• kukhalapo kwa tsankho kwa yogwira pophika.

Kodi pali kusiyana kotani pakati pa glucophage ndi metformin?

Glucophage ndilo dzina lamalonda lamankhwala, ndi zomwe zimagwira. Glucophage si mtundu wokhawo wapiritsi womwe umagwira ndi metformin. Pamankhwala mutha kugula mankhwalawa a matenda a shuga komanso kuti muchepetse kunenepa pansi pa mayina osiyanasiyana. Mwachitsanzo, Siofor, Glformin, Diaformin, etc. Komabe, Glucofage ndi mankhwala ochokera kunja omwe amagulitsidwa kunja. Siotsika mtengo kwambiri, koma amaonedwa kuti ndi wapamwamba kwambiri. Mankhwalawa ali ndi mtengo wotsika mtengo kwambiri, ngakhale kwa nzika zapamwamba, chifukwa tsambalo silikulimbikitsa kuyesa anzawo otsika mtengo.

Kodi pali kusiyana kotani pakati pa glucophage nthawi zonse ndi glucophage yayitali? Ndi mankhwala ati omwe ali bwino?

Glucophage Long - ichi ndi piritsi lomwe limamasulidwa pang'onopang'ono pazomwe zimagwira. Amayamba kuchita mochedwerapo kuposa Glucophage yokhazikika, koma zotulukapo zawo zimakhala motalikitsa. Izi sizikutanthauza kuti mankhwala ena ndi abwino kuposa enawo. Amapangidwira zolinga zosiyanasiyana. Mankhwala otulutsidwa nthawi zambiri amatengedwa usiku kuti m'mawa wotsatira pakhale shuga wamba wamagazi. Komabe, mankhwalawa ndi oyipa kuposa glucofage wokhazikika, oyenera kuwongolera shuga tsiku lonse. Anthu omwe mapiritsi a metformin okhazikika amayambitsa matenda otsegula m'mimba amalangizidwa kuti ayambe kumwa mankhwalawa osathamanga kuti awonjezere. Ngati izi sizikuthandizani, ndiye kuti muyenera kusinthira ku kudya kwa tsiku ndi tsiku kwa mankhwala Glucofage Long.

Kodi ndiyenera kudya zakudya ziti mukamamwa mankhwalawa?

Ili ndiye njira yoyenera yothetsera odwala omwe ali ndi kunenepa kwambiri, prediabetes ndi matenda a shuga 2. Afufuzeni ndikuwachotseratu pachakudya chanu. Idyani zabwino komanso zathanzi, zomwe mungagwiritse ntchito. Zakudya zama carb ochepa ndizo chithandizo chachikulu cha matenda ashuga amtundu wa 2. Iyenera kuthandizidwa ndikugwiritsa ntchito mankhwalawa Glucophage, ndipo, ngati pakufunika,, jekeseni wa insulini wochepa. Kwa anthu ena, zakudya zamafuta ochepa zimakuthandizani kuti muchepetse thupi, pomwe ena, sichoncho. Komabe, iyi ndi chida chabwino kwambiri chomwe tili nacho. Zotsatira za kudya kwamafuta ochepa, zamafuta ochepa kwambiri ndi zoyipa kwambiri. Mwa kusinthira ku chakudya chamafuta ochepa, muthanso shuga wanu wamagazi, ngakhale ngati simungathe kuchepetsa thupi kwambiri.

Werengani mwatsatanetsatane zamalonda:

Glucophage ndi kuyendetsa

Kugwiritsa ntchito mankhwalawa nthawi zambiri sikugwirizana ndi vuto loyendetsa kapena magwiridwe antchito. Koma chithandizo chovuta kwambiri chimatha kukhala pachiwopsezo cha hypoglycemia. Pankhaniyi, muyenera kufunsa dokotala.

Timayesetsa kukupatsani chidziwitso chofunikira komanso chothandiza kwa inu ndi thanzi lanu. Zinthu zomwe zili patsamba lino ndizachidziwitso ndipo cholinga chake ndi kuphunzitsa.Alendo otsamba sayenera kuwagwiritsa ntchito ngati malangizo azachipatala. Kudziwa dokotala komanso kusankha njira zamankhwala ndikungokhala dokotala! Sikuti tili ndi vuto lililonse chifukwa chogwiritsa ntchito zidziwitso zomwe zalembedwa patsamba lino

Kulephera kuchita masewera olimbitsa thupi komanso kukonda kudya kwambiri kumangowonjezera kulemera kwakukulu, komanso matenda omwe amayamba chifukwa cha zovuta za metabolic monga kunenepa kwambiri, matenda oopsa komanso matenda ashuga. Kwa gulu lotsiriza la odwala, makampani opanga mankhwala amapanga mankhwala omwe amachepetsa glucose wamagazi ndikuthandizira kuchepetsa thupi. Glucophage imakhalanso ya mankhwalawa, omwe amagwiritsidwanso ntchito ndi anthu athanzi ngati mapiritsi azakudya.

Malamulo ogwiritsira ntchito

Sizotheka kupeza chiwembu chogwiritsa ntchito Glucofage pakuchepetsa thupi m'malamulo aboma. Mankhwala adapangira wina.

Koma modzikakamiza amapanga malingaliro ochepa:

1. Nthawi ya mapiritsi olimbitsa mosalekeza kuyambira masiku 10 mpaka 21.
   Ngati mumamwa zochepa, zotsatira zake sizingamveke.
   Komabe, kudya kwakutali kungayambitse kusuta, komwe kumathandizanso kuchiritsa kwa zero.
2. Kupuma pakati pa maphunziro kuyenera kukhala miyezi iwiri.

1. Mlingo watsiku ndi tsiku umachokera ku 500 mpaka 3000 mamilimita achinthu chomwe chimagwira ndipo chimasankhidwa payekhapayekha.
   Ndikwabwino kuyamba ndi kuchuluka kochepa ndipo posakhala ndi zotsatirazi zomwe zafotokozedwa pamwambapa, mulingo ungathe kuchuluka.
2. Mapiritsi a Glucophage amatsukidwa ndi kuchuluka kwa madzi osakhala ndi kaboni, kudya kumachitika katatu patsiku panthawi ya chakudya kapena nthawi yomweyo.
3. Panthawi yamankhwala, ndizoletsedwa kugwiritsa ntchito zakudya zopatsa mphamvu zopatsa mphamvu zochepa.
   Komano, zakudya zopatsa mpweya kwambiri (maswiti), zakumwa zozizilitsa kukhosi, ndi zipatso zouma zambiri nthawi zambiri zimayambitsa matenda am'mimba ndi kusanza.
   Pankhaniyi, zabwino zomwe amatenga zimachepetsedwa.
4. Masewera saloledwa, kuwonjezera apo, osewera ambiri amagwiritsa ntchito Glyukofazh pazomwe zimatchedwa "kuyanika" zisanayambe.
   Mwanjira ina, thamangitsani mwachangu kulemera kwa magawo ofunikira.

Kodi glucophage imachulukitsa kapena kuchepetsa magazi?

Glucophage sikuchulukitsa magazi. Zimawonjezera pang'ono zotsatira zamapiritsi oopsa - okodzetsa, beta-blockers, ACE inhibitors ndi ena.

Kwa odwala matenda ashuga omwe amathandizidwa molingana ndi njira zamasamba, kuthamanga kwa magazi kumatsikira mwachangu. Chifukwa zimachita monga choncho. Amachotsa madzimadzi owonjezera kuchokera mthupi, amachotsa edema ndikuwonjezera nkhawa pamitsempha yamagazi. Glucophage ndi mankhwala osokoneza bongo oonjezera amathandizira pang'ono zomwe zimachitika wina ndi mnzake. Ndi kuthekera kwakukulu, mudzafunika kusiyiratu mankhwala omwe amachepetsa kuthamanga kwa magazi. Izi sizokhumudwitsa :).

Kodi mankhwalawa amagwirizana ndi mowa?

Glucophage imagwirizana ndi kumwa moyenera. Kumwa mankhwalawa sikutanthauza kukhala ndi moyo wopanda nkhawa. Ngati palibe zotsutsana pakutenga metformin, ndiye kuti simukuletsedwa kumwa pang'ono. Werengani nkhaniyo "", ili ndi zambiri zothandiza. Mwawerenga pamwambapa kuti metformin ili ndi chowopsa koma chosowa kwambiri - lactic acidosis. Nthawi zambiri, mwayi wokhala ndi vutoli ndi pafupifupi zero. Koma imakwera ndi kuledzera kwambiri. Chifukwa chake, mosiyana ndi maziko a kumwa metformin sayenera kuledzera. Anthu omwe sangakhale osamala kwambiri ayenera kupewa mowa.

Zoyenera kuchita ngati glucophage sichithandiza? Ndi mankhwala ati omwe ali ndi mphamvu?

Ngati Glucophage atatha kudya masabata ochepa a 6-8 osathandiza kuti muchepetse makilogalamu angapo onenepa kwambiri, tengani mayeso a magazi a mahomoni a chithokomiro, kenako mukaonane ndi endocrinologist.Ngati hypothyroidism (kusowa kwa mahomoni a chithokomiro) akapezeka, muyenera kuthandizidwa ndi mapiritsi a mahomoni omwe dokotala wanu wakupatsani.

Mwa odwala ena omwe ali ndi matenda a shuga a 2, glucophage samachepetsa shuga ya magazi konse. Izi zikutanthauza kuti kapamba watha, kupanganso insulin yake kwatha, matendawa akusintha ngati matenda ashuga akulu amodzi. Mosakhalitsa muyenera kuyamba kubaya insulin. Amadziwikanso kuti mapiritsi a metformin sangathe kuthandiza odwala matenda ashuga. Odwala otere amafunika mwachangu, osasamala mankhwalawo.

Kumbukirani kuti cholinga chamankhwala othandizira odwala matenda ashuga ndizosungitsa shuga nthawi zonse mkati mwa 4.0-5,5 mmol / L. Ambiri mwa anthu odwala matenda ashuga, glucophage amatsitsa shuga, koma osakwanira kuti abweze mwakale. Ndikofunikira kudziwa kuti ndi nthawi yanji ya kapamba yomwe singathe kuthana ndi katundu, ndikuthandizira ndi jakisoni wa insulini yochepa. Musakhale aulesi kugwiritsa ntchito insulin kuwonjezera pa kumwa mankhwala ndi kudya. Kupanda kutero, zovuta za matenda ashuga zimayamba, ngakhale ndi shuga za 6.0-7.0 ndi apamwamba.

Ndemanga ya anthu omwe amamwa Glucofage kuti achepetse thupi komanso chithandizo chamankhwala a shuga 2 amatsimikizira kuti mapiritsiwa ndi othandizira. Amathandizira bwino kuposa mitengo yamtengo wapatali yopanga Russian. Zotsatira zabwino zimapezeka ndi odwala omwe amayang'ana kumbuyo kwa mapiritsi. Odwala omwe ali ndi matenda a shuga a mtundu wachiwiri amatha kuchepetsa shuga kuti akhale bwino monga momwe amakhalira anthu athanzi. Ambiri m'mawunikidwe awo amadzitamandanso kuti amatha kutaya makilogalamu 15 mpaka 20 owonjezera. Ngakhale chitsimikizo cha kuchepetsa kulemera sichingaperekedwe pasadakhale. Tsamba limatsimikizira odwala matenda ashuga kuti azitha kuyendetsa matenda awo, ngakhale zitakhala kuti sizikuyenda bwino amachepetsa thupi.

Anthu ena amakhumudwitsidwa kuti Glucophage sikuti imayambitsa kuwonda msanga. Zowonadi zake, momwe zimakhalira pakuwonekera zimawonekera pasanathe milungu iwiri, makamaka mukayamba kulandira chithandizo chochepa. Mukamachepetsa thupi, mumakhala ndi mwayi wokulirapo zotsatira zazitali. Mankhwala Glucophage Long ndiwocheperako kuposa mankhwala ena onse a metformin kuyambitsa matenda am'mimba komanso zotsatira zina zoyipa. Kwa anthu omwe akufuna kuchepa thupi, zimathandiza kwambiri. Koma mankhwalawa siabwino kwenikweni kuwongolera shuga m'magazi odwala matenda ashuga pambuyo kudya masana.

Ndemanga zoyipa zam'mapiritsi a Glucofage amasiyidwa ndi odwala omwe ali ndi matenda amtundu wa 2 omwe sakudziwa zakudya zamafuta ochepa kapena safuna kusintha. , wadzaza ndi chakudya chamafuta, umawonjezera shuga m'magazi ndikukhala bwino. Kukonzekera kwa Metformin ngakhale jakisoni wa insulin sangabwezele zolakwika zawo. Mwa odwala matenda ashuga omwe amatsatira zakudya zamagulu ochepa zopatsa mphamvu, zotsatira za chithandizo chake sizabwino. Siyenera kulingaliridwa kuti izi zimachitika chifukwa cha kufooka kwa mankhwalawa.

Chipatso cha Matenda A shuga

Ndemanga 53 pa "Glucophage ndi Glucophage Long"

1. Julia
   
2. Yuri Stepanovich
   
3. Oksana
   
4. Natalya
   
5. Rimma
   
6. GALINA
   
7. Irina
   
8. Natalya
   
9. Natalya
   
10. Irina
    
11. Svetlana
    
12. Victoria
    
13. Irina
    
14. Irina
    
15. Natalya

Oral hypoglycemic mankhwala ochokera pagulu la Biguanide.

Kukonzekera: GLUCOFAGE
Chithandizo chogwira ntchito: metformin
Code ya ATX: A10BA02
KFG: Oral hypoglycemic mankhwala
Reg. nambala: P No. 014600/01
Tsiku lolembetsa: 08/13/08
Mwini reg. acc.: NYCOMED AUSTRIA GmbH

FOMU YA DOSAGE, KULIMA NDI KUSANGALATSA

Mapiritsi okhala ndi mbali yoyera, filimu, yozungulira, ya biconvex, pamtanda - gulu loyera lalikulu.

Othandizira: povidone, magnesium yakubayo.

Zomwe zimapangidwa ndi chipolopolo: hypromellose.

Mapiritsi okhala ndi mbali yoyera, filimu, yozungulira, ya biconvex, pamtanda - gulu loyera lalikulu. biconvex.

Othandizira: povidone, magnesium yakubayo.

Zomwe zimapangidwa ndi chipolopolo: hypromellose

15 ma PC. - matuza (2) - mapaketi a makatoni.
20 ma PC.- matuza (3) - mapaketi a makatoni.
20 ma PC. - matuza (5) - mapaketi a makatoni.

Mapiritsi okhala ndi mbali filimu yoyera, filimu, chowolokera, biconvex, yokhala ndi notch mbali zonse ziwiri ndikujambula "1000" mbali imodzi, pamtanda wa mtanda - misa yoyera yayikulu.

Othandizira: povidone, magnesium yakubayo.

Zomwe zimapangidwa ndi chipolopolo: oyera opadra (hypromellose, macrogol 400, macrogol 8000).

Ma PC 10 - matuza (3) - mapaketi a makatoni.
Ma PC 10 - matuza (5) - mapaketi a makatoni.
Ma PC 10 - matuza (6) - mapaketi a makatoni.
Ma PC 10 - matuza (12) - mapaketi a makatoni.
15 ma PC. - matuza (2) - mapaketi a makatoni.
15 ma PC. - matuza (3) - mapaketi a makatoni.
15 ma PC. - matuza (4) - mapaketi a makatoni.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Oral hypoglycemic mankhwala ochokera pagulu la Biguanide.

Glucophage imachepetsa hyperglycemia, popanda kutsogola kukula kwa hypoglycemia. Simalimbikitsa insulin katemera ndipo ilibe gawo la hypoglycemic mwa anthu athanzi.

Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndipo zimathandizira kuyamwa kwa glucose ndi maselo amisempha. Amalepheretsa gluconeogenesis m'chiwindi. Iachedwetsa kuyamwa kwa mafuta m'matumbo. Ili ndi phindu pa metabolidi ya lipid: imatsitsa cholesterol yathunthu, triglycerides ndi LDL.

Mutatha kumwa mankhwalawo mkati, metformin imatenga gawo lonse la chakudya. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. Mtheradi bioavailability ndi 50-60%. C max mu plasma pafupifupi 2 μg / ml kapena 15 μmol ndipo umatheka pambuyo maola 2,5.

Metformin imagawidwa mwachangu mu minofu ya thupi. Sizikugwirizana ndi mapuloteni a plasma.

Amachepetsa pang'ono ndi kupukusidwa ndi impso.

Kuvomerezeka kwa metformin mwa anthu athanzi ndi 440 ml / min (kanthawi kuposa KK), komwe kumawonetsa katulutsidwe ka tubular.

T 1/2 pafupifupi maola 6.5.

Pharmacokinetics mu milandu yapadera yamankhwala

Odwala omwe amalephera kupezeka ndi aimpso, T 1/2 amachulukirapo, pamakhala chiopsezo cha kuchuluka kwa metformin mthupi.

Type 2 shuga mwa akulu,

Kuphatikiza ndi insulin ya mtundu 2 matenda a shuga, makamaka kunenepa kwambiri ndi kukana kwa insulin,

Type 2 shuga mellitus mwa ana opitirira zaka 10 (monotherapy, osakanikirana ndi insulin).

Monotherapy ndi kuphatikiza mankhwalawa ndi ena othandizira pakamwa

Akuluakulu, mlingo woyambirira ndi 500 mg 2-3 nthawi / tsiku mutatha kapena mukudya. Kuwonjezereka kwapang'onopang'ono kwa mlingo kumatha kutengera kuchuluka kwa shuga m'magazi.

Njira yokonza tsiku ndi tsiku ndi 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo, mankhwalawa amayenera kugawidwa pakamwa katatu. Mlingo wapamwamba wa tsiku ndi tsiku ndi 3000 mg / tsiku, logawidwa pazigawo zitatu.

Kuchepetsa pang'ono kwa mankhwalawa kungathandize kusintha kulolerana kwa m'mimba.

Odwala omwe akutenga metformin mu Mlingo wa 2000-3000 mg / tsiku amatha kusamutsidwa kuti alandire Glucofage 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Ngati mukufuna kusintha kuti muthane ndi mankhwala a Glucofage ndi wothandizanso wina wa hypoglycemic, muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa Glucophage muyezo womwe ukunenedwa pamwambapa.

Kuphatikiza kwa insulin

Kukwaniritsa bwino glycemia, metformin ndi insulin zingagwiritsidwe ntchito pophatikiza mankhwala.

Mlingo woyambirira wa mankhwala Glucofage mu mlingo wa 500 mg ndi 850 mg ndi 1 tabu. 2-3 nthawi / tsiku, Mankhwala Glucofage muyezo wa 1000 mg ndi 1 tabu. 1 nthawi / tsiku Mlingo wa insulin umasankhidwa potengera zotsatira za kuyeza magazi.

Glucophage ingagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza ndi insulin. Mlingo woyambirira ndi 500 mg katatu / tsiku mukatha kudya kapena musanadye.Pambuyo masiku 10-15, mlingo uyenera kusinthidwa kutengera zotsatira za kuyeza magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

At odwala okalamba chifukwa cha kuchepa kwa ntchito yaimpso, mlingo wa metformin uyenera kusankhidwa poyang'aniridwa nthawi zonse owonetsa aimpso (kuwunika kwa serum creatinine osachepera 2-4 pachaka). Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa odwala azaka zopitilira 60 kugwira ntchito molimbika.

Pafupipafupi zotsatira zoyipazi zimawunikira motere: kawirikawiri (? 1/10), kawirikawiri (? 1/100, MITU YA NKHANI

Kuwonongeka kwa impso (Q. PREGNANCY NDIPO KUPEMBEDZA

Mankhwalawa amayesedwa kuti agwiritse ntchito panthawi yoyembekezera komanso panthawi yoyamwitsa.

Mukakonzekera kapena poyambitsa kutenga pakati, glucophage iyenera kusiyidwa ndipo mankhwala a insulin atchulidwa. Wodwala ayenera kuchenjezedwa za kufunika kodziwitsa dokotala ngati ali ndi pakati. Amayi ndi mwana ayenera kuyang'aniridwa.

Sizikudziwika ngati metformin yachotsedwa mkaka wa m'mawere. Ngati ndi kotheka, ntchito mankhwalawa pa mkaka wa m`mawere ayenera kusiya kuyamwitsa.

Wodwalayo ayenera kuchenjezedwa za kufunika kosiya kumwa mankhwalawo ndikuwonana ndi dokotala ngati kusanza, kupweteka kwam'mimba, kupweteka kwa minofu, kufooka kwapafupipafupi ndi kuonekera kwambiri. Zizindikiro izi zitha kukhala chizindikiro cha kulowerera lactic acidosis.

Glucophage iyenera kuyimitsidwa maola 48 isanachitike komanso mkati mwa maola 48 atawunika X-ray (kuphatikiza urography, intravenous angiography) ogwiritsa ntchito ma radiopaque othandizira.

Popeza metformin imachotsedwa mu mkodzo, milingo ya serum creatinine iyenera kutsimikizika musanayambe chithandizo ndi mankhwalawa komanso pafupipafupi.

Kusamala makamaka kuyenera kuchitika ngati vuto laimpso likuwonekera, mwachitsanzo, munthawi ya chithandizo cha antihypertensive mankhwala, okodzetsa, NSAIDs.

Mudziwitse wodwalayo za kufunika kofunsa dokotala ngati zikuoneka kuti muli ndi matenda a bronchopulmonary kapena matenda opatsirana a ziwalo zoberekera.

Potengera momwe mankhwalawa amagwiritsidwira ntchito mankhwalawa Glucofage, munthu ayenera kupewa kumwa mowa.

Kugwiritsa Ntchito Kwa Ana

At ana opitilira zaka 10 Glucophage ingagwiritsidwe ntchito onse mu monotherapy komanso kuphatikiza ndi insulin.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Monotherapy yokhala ndi Glucophage siyimayambitsa hypoglycemia chifukwa chake sichikhudza kuthekera koyendetsa galimoto ndikugwira ntchito ndi zida. Komabe, odwala ayenera kusamala za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin molumikizana ndi othandizira ena a hypoglycemic (kuphatikizapo zotumphukira za sulfonylurea, insulin, repaglinide).

Zizindikiro ntchito Glucophage muyezo wa 85 g, hypoglycemia sichinawoneke, komabe, kukula kwa lactic acidosis kunadziwika. Zizindikiro zoyambirira za lactic acidosis ndi mseru, kusanza, kutsegula m'mimba, kutentha thupi, kupweteka m'mimba, kupweteka kwa minofu, mtsogolo ndikotheka kuwonjezera kupuma, chizungulire, chikumbumtima chovuta, kukula kwa chikomokere.

Chithandizo: kuthetseratu mwachangu wa Glucofage, kuchipatala mwachangu, kutsimikiza kwa ndende ya lactate m'magazi, ngati kuli kotheka, kuchita mankhwala. Kuchotsa lactate ndi metformin m'thupi, hemodialysis imakhala yothandiza kwambiri.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Glucofage ndi danazole, kukula kwa vuto la hyperglycemic ndikotheka. Ngati mankhwala a danazol akufunika ndipo atayimitsa, kusintha kwa Glucofage kumafunika muulamuliro wa glycemia.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala Glucofage ndi zakumwa zoledzeretsa ndi ethanol, chiopsezo chotenga lactic acidosis panthawi yoledzera ya mowa umachulukirachulukira, makamaka mukasala kudya kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera.

Kuphatikiza komwe kumafunikira chisamaliro chapadera

Chlorpromazine mu Mlingo wambiri (100 mg / tsiku) amachepetsa kutulutsa insulin ndikuwonjezera kuchuluka kwa shuga m'magazi. Pogwiritsa ntchito nthawi yomweyo ma antipsychotic ndipo atayimitsa makina awo, kusintha kwa Glucofage kumafunikira motsogozedwa ndi glycemia level.

GCS (yogwiritsidwa ntchito mwa makina ndi apakhungu) imachepetsa kulolera kwa shuga ndikuwonjezera kuchuluka kwa shuga m'magazi ena mwanjira yoyambitsa ketosis. Ngati mukufunikira kugwiritsa ntchito kuphatikiza uku ndikusiya kuyendetsa makina a GCS, kusintha kwa Glucofage kumafunikira motsogozedwa ndi glucose level.

Pogwiritsa ntchito munthawi yomweyo "ma loop" okodzetsa komanso Glucophage, pamakhala chiopsezo cha lactic acidosis chifukwa chowoneka ngati kulephera kwaimpso. Glucophage sayenera kufotokozedwa ngati QC ZOTHANDIZA KUTENGA UTHENGA WABWINO

Mankhwala ndi mankhwala.

MITU YA NKHANI NDI ZOTHANDIZA ZA STORAGE

Mankhwalawa amayenera kusungidwa kuti ana asawatenthe pa kutentha osaposa 25 ° C. Alumali moyo mapiritsi a 500 mg ndi 850 mg ndi zaka 5. Moyo wa alumali wa mapiritsi a 1000 mg ndi zaka zitatu.

Si chinsinsi kuti anthu ambiri masiku ano amalota kuti akhale ochepa thupi komanso athanzi. Oimira atsikana oyenera amafuna makamaka kuchepetsa thupi. Komabe, ndi angati mwa anthuwa amene amayesetsa kuchita izi? Pa intaneti pali zidziwitso zambiri zamomwe mungadye moyenera, zolimbitsa thupi zolimbitsa thupi ndi zomwe mungachite kuti zolemerazo zitheke popanda kupweteka. Komabe, ndizosavuta kungotenga mapiritsi amatsenga omwe angakuchitire zonse. Chokhacho chomwe chatsala kuti mukhale ndi moyo, monga kale: imwani mitundu yambiri ya zinthu zoyipa ndikuyamba kumangokhala.

Nthawi zambiri, anthu amangopita kukadokotala kukafufuza njira zomwe zingawathandize kutaya mapaundi ochepa mu sabata popanda kuyesetsa. Ndipo lingaliro lawo ndi ili: popeza mapiritsi amagulitsidwa pa mankhwala, zikutanthauza kuti sangakhale ovulaza thanzi. Komabe, nthawi zambiri anthu omwe amagonjera kukopa kutsatsa, amagula mankhwala osokoneza bongo, osadziwa cholinga chake. Munkhaniyi tikambirana za mankhwala "Glucofage". Ndemanga zakuchepetsa thupi zimatsimikiziradi kuti chidacho ndichothandiza kwambiri. Komabe, mankhwalawo pawokha amalembera anthu omwe ali ndi matenda a shuga.

Chifukwa chiyani chida ichi chimatsogolera kuwonda

Mapiritsi a Glucophage amafotokozedwa mu malangizo ogwiritsira ntchito ngati njira yochizira matenda a shuga a 2. Komabe, mankhwalawa amagwiritsidwa ntchito nthawi zambiri moyenera kuchepetsa thupi. Chifukwa chiyani mankhwalawa amatchuka kwambiri ndi anthu oonda?

Metformin imatha kuchepetsa shuga m'magazi, omwe amakwera kwambiri pambuyo pa chakudya chilichonse. Njira zoterezi zimakhala zachilengedwe mthupi, koma ndi matenda ashuga amasokonezeka. Komanso mahomoni opangidwa ndi kapamba amalumikizidwa ndi njirayi. Amathandizira pakusintha shuga kukhala maselo amafuta.

Chifukwa chake, kumwa mankhwalawa, odwala amatha kuwongolera shuga, komanso kusintha momwe timadzi mu thupi timagwirira ntchito. Metformin imakhala yosangalatsa kwambiri mthupi la munthu. Amachepetsa kwambiri magazi chifukwa cha kudya mwachindunji kwa minofu minofu. Chifukwa chake, shuga amayamba kuwotcha, osasanduka mafuta osungira. Kuphatikiza apo, mankhwalawa "Glucophage" ali ndiubwino wina. Ndemanga zakuchepetsa thupi zimatsimikizira kuti chida ichi chimapangitsa kuti chishuwere. Zotsatira zake, munthu samangodya chakudya chochuluka.

"Glucophage": malangizo ogwiritsira ntchito

Kumbukirani kuti, kudzipereka nokha si njira imodzi. Mankhwala oterowo ayenera kuyikidwa kokha ndi katswiri. M'malo mwake, owerengeka kwambiri amathandizira odwala awo kumwa mapiritsi a Glucofage moyenera kuti achepetse thupi. Chida choterocho chikuyenera kugwiritsidwa ntchito, motsogozedwa ndi dongosolo lapadera. Nthawi zambiri, njira ya mankhwalawa imatenga masiku 10 mpaka 22, pambuyo pake ndikulimbikitsidwa kuti mupumule kwa miyezi iwiri. Pambuyo pa nthawi iyi, ngati pangafunike, maphunzirowo atha kubwereza.Chonde dziwani kuti, ngati mumagwiritsa ntchito mankhwalawa pafupipafupi, pali kuthekera kwakukulu koti thupi lanu limangogwiritsa ntchito, zomwe zikutanthauza kuti njira yoyaka mafuta idzayimitsidwa.

Mlingo amasankhidwa ndi dokotala payekhapayekha. Katswiriyu ayenera kuganizira za thanzi lanu, komanso jenda, kulemera kwake komanso kutalika kwake. Komabe, mlingo wocheperako tsiku lililonse ndi piritsi limodzi lokhala ndi 500 mg yogwira ntchito patsiku. Koma nthawi zambiri pakuchepetsa thupi mankhwala "Glucofage" siomwe amatengedwa. Ndemanga zakuchepetsa thupi zimatsimikizira kuti zotsatira zabwino kwambiri zimatheka pokhapokha mutamwa mapiritsi awiri a mankhwalawa tsiku lililonse. Nthawi yomweyo, muyenera kuchita izi nthawi ya nkhomaliro komanso madzulo. Osati kawirikawiri, mlingo umakulitsidwa kumapiritsi atatu patsiku. Komabe, kuchuluka kwa mankhwalawa kungapangidwe ndi dokotala.

Anthu ambiri ali ndi chidwi ndi funso lofunsidwa: Kodi ndibwino - "Glyukofazh" kapena "Glukofazh Long"? Dokotala wanu adzayankha funso ili. Ngati mankhwalawa okwanira a metformin ndi oyenera kwa inu, ndiye kuti ndibwino kulabadira mankhwala achiwiriwo, chifukwa amakhala ndi mphamvu yayitali mthupi. Piritsi lililonse liyenera kumwedwa nthawi yomweyo musanadye kapena chakudya. Imwani mapiritsiwo ndi madzi pang'ono. Ndikofunika kuwonjezera mlingo pang'onopang'ono. Izi zithandiza bwino m'mimba thirakiti.

Musaiwale kuti Glucophage, mtengo womwe umasonyezedwa pansipa, siwowonjezera vitamini. Mankhwalawa amapangidwa makamaka pochiza matenda amishuga a 2. Chifukwa chake, muyenera kuigwiritsa ntchito mosamala kwambiri, chifukwa mankhwalawo ali ndi zambiri zotsutsana.

Chonde dziwani kuti kusankha kolakwika kwakanthawi kungapangitse kuti thupi la munthu lisayankenso insulin yomwe imapanga payokha. Ndipo izi, posachedwa, zidzatsogolera kukukula kwa matenda ashuga. Ndipo izi zitha kuchitika ngakhale mutakhala kuti simunayang'anitsidwe ndi matenda oopsa ngati amenewa.

Palibe chifukwa osatenga mankhwalawa "Glyukofazh" (mtengo wa nega umasiyana m'chigawo cha ma ruble mazana awiri kapena mazana anayi) ngati mwazindikira chidwi ndi zigawo za constituent. Komanso, musamwe mankhwalawa kuti muchepetse thupi ngati muli ndi matenda amtima komanso ma mtima. Zachidziwikire, simungagwiritse ntchito mankhwala a ana, komanso azimayi oyembekezera komanso oyembekezera. Simuyenera kuigwiritsa ntchito ngati mukudwala matenda omwe ali pachimake pakukula. Komanso, musayese thanzi lanu ngati mukudwala matenda ashuga. Mwachitsanzo, musagwiritse ntchito mankhwalawa kuchiza matenda a shuga 2 ngati muli ndi matenda ashuga 1.

Glucophage: mavuto

Musaiwale kuti chida ichi chinapangidwira makamaka kuti chikhale ngati wodwala akudwala matenda ashuga. Mankhwalawa ndi akulu kwambiri, chifukwa chake ali ndi mndandanda waukulu wazotsatira zoyipa. Nthawi zambiri, odwala omwe amamwa mankhwalawa makamaka kuti achepetse thupi amadandaula za zotsatira zoyipa zamagetsi. Nthawi zambiri pamakhala mseru komanso kusanza, komanso kutsegula m'mimba, kapena, kudzimbidwa. Ngati mungazindikire kuti mudayamba kuvutika chifukwa cha kuchuluka kwa mpweya m'matumbo, ndiye kuti mumadya chakudya chochuluka kwambiri. Pankhaniyi, muyenera kusintha zakudya zanu momwe mungathere. Ngati mukuwona nseru, ndiye kuti mankhwalawa amasankhidwa molakwika. Muyenera kuti muchepetse.

Nthawi zambiri limodzi ndi zoyipa kumayambiriro kwa chithandizo, kumwa mankhwalawa "Glucofage" kuwonda. Ndemanga za madotolo ndi odwala akufotokozedwa pansipa, ndipo muyenera kuzidziwa bwino musanayambe kumwa mankhwalawa. Komabe, patatha masiku ochepa, wodwalayo amayamba kumva kuti ndi wabwinobwino.

Nthawi zina, matenda a lactic acidosis amatha kuyamba. Amayamba chifukwa cha kusokonezeka kwa lactic acid metabolism m'thupi. Zimadzipangitsa kukhala ngati kusanza kosalekeza ndi mseru. Nthawi zina pamakhala zowawa m'mimba. Nthawi zambiri, odwala amayamba kusiya kuzindikira. Pankhaniyi, kumwa mankhwalawa kuyenera kuyimitsidwa mwachangu. Kuti athetse mawonekedwe owoneka bwino, madokotala nthawi zambiri amapereka mankhwala othandizira. Chonde dziwani kuti kugwiritsa ntchito mosayenera komanso mosasamala mankhwala omwe ali ndi metformin kukhoza kuwononga thanzi lanu. Chifukwa chake, mugwireni ndi udindo wonse. Mlingo wowonjezereka wa metformin ungayambitse njira zina zosasintha zomwe zimachitika mu ubongo.

Ngati mukuganiza kuti mutenge mankhwala oti "Glucofage" kuti muchepetse thupi, mulingo woyenera uyenera kukhala wochepa. Komanso, ngati simutsatira mfundo za zakudya zoyenera, ndiye kuti simungathe kudalira zotsatira zabwino. Muyenera kupatula zakudya zomwe zili ndi chakudya chambiri kuchokera kuzakudya zanu. Choyamba, maswiti ndi zipatso zouma ziyenera kutchulidwa apa.

Komanso musayese kudya phala la mpunga, mbatata ndi pasitala. Palibe chifukwa choti musakhale pachakudya chamafuta ochepa, pomwe muzidya zosakwana kilositeti chikwi. Dziwani kuti Glucophage ndi mowa sizigwirizana kwathunthu. Koma mutha kugwiritsa ntchito zonunkhira ndi mchere mulingo uliwonse. Palibe zoletsa zapadera kwa iwo.

Kodi ndingachite masewera ndikumwa mankhwala ochepetsa thupi?

Mpaka posachedwa, madokotala adanenanso kuti mukamachita masewera, muthana ndi zotsatira zonse za kumwa mapiritsi a Glucophage. Komabe, chifukwa cha kafukufuku waposachedwa, asayansi adazindikira kuti kuchita masewera olimbitsa thupi ndikukhalabe ndi moyo wogwira ntchito, m'malo mwake, imathandizira njira yochepetsera thupi kangapo. Ngakhale odwala omwe amamwa mankhwalawa Glucofage mumiyeso yaying'ono kwambiri ndikusewera masewera amasangalala kwambiri ndi zotsatira zake. Musaiwale kuti metformin imalimbikitsa kutuluka kwa glucose mwachindunji kumisempha minofu. Chifukwa chake, pochita masewera olimbitsa thupi, mumawotcha chakudya chonse chomwe mumadya. Kupanda kutero, shuga, posachedwa, amakhalabe mafuta amthupi lanu. Ngati mukuganiza zopanga kuchepa thupi mothandizidwa ndi mankhwalawa, onetsetsani kuti mwapanga dongosolo la masewera olimbitsa thupi, komanso kuwerenganso zakudya. Ndipo zotsatira zabwino sizitenga nthawi yayitali.

Mankhwala

Metformin imachepetsa mawonetseredwe a hyperglycemia, poletsa kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, mankhwalawa sathandizira kupanga insulin mthupi ndipo silikhala ndi vuto la thanzi. Metformin imachepetsa chidwi cha zotumphukira zolandilira ku insulin ndikuthandizira kugwiritsidwa ntchito kwa glucose m'maselo, komanso imalepheretsa kaphatikizidwe ka glucose pachiwindi chifukwa choletsa glycogenolysis ndi gluconeogeneis. Vutoli limachepetsa kuyamwa kwa shuga m'matumbo.

Metformin imayendetsa kaphatikizidwe ka glycogen pochita glycogen synthase ndikuwonjezera kuthekera kwamitundu yonse yamtundu wama glucose oyenda. Amakhudzanso kukonzekera kwa lipid metabolism, kuchepetsa kuchuluka kwa triglycerides, otsika osalimba lipoprotein ndi cholesterol yonse.

Poyerekeza ndi momwe chithandizo cha Glucofage chilili, thupi la wodwalayo mwina limakhalabe lokha kapena limachepetsedwa pang'ono.

Kafukufuku wachipatala amatsimikizira mphamvu ya mankhwalawa popewa matenda ashuga odwala matenda ashuga omwe ali ndi chiwopsezo chowonjezereka cha kukhazikitsidwa kwa matenda ashuga a 2 ngati njira yotsimikizika isintha sikutsimikizira kuti matendawa ndi olondola.

Malangizo ogwiritsira ntchito Glucofage: njira ndi mlingo

Glucophage iyenera kutengedwa pakamwa.

Kwa akulu, mankhwalawa angagwiritsidwe ntchito ngati monotherapy kapena munthawi yomweyo ndi mankhwala ena a pakamwa a hypoglycemic.

Kumayambiriro kwa chithandizo, Glucofage 500 kapena 850 mg nthawi zambiri imayikidwa. Mankhwalawa amatengedwa katatu patsiku ndi chakudya kapena akangomaliza kudya. Kutengera kuchuluka kwa shuga m'magazi, kuwonjezereka kwapang'onopang'ono kwa mlingo kumatheka.

Njira yokonzanso tsiku lililonse la Glucofage nthawi zambiri imakhala 1,500-2,000 mg (pazipita 3,000 mg). Kumwa mankhwalawa katatu patsiku kumachepetsa kuopsa kwa mavuto am'mimba. Komanso, kuwonjezeka kwapang'onopang'ono kwa mlingo kungapangitse kusintha kwa kulekerera kwa m'mimba kwa mankhwalawa.

Odwala omwe amalandila metformin mu Mlingo wa 2000-3000 mg tsiku akhoza kusamutsidwa kupita ku Glucofage pa mlingo wa 1000 mg (pazipita - 3000 mg patsiku, wogawidwa 3 waukulu). Mukakonzekera kusinthaku kuti mumwe mankhwala ena a hypoglycemic, muyenera kusiya kumwa ndikuyamba kugwiritsa ntchito Glucofage pamwambapa.

Kuti mukwaniritse bwino shuga wamagazi, metformin ndi insulin zingagwiritsidwe ntchito munthawi yomweyo. Mlingo umodzi woyamba wa Glucofage nthawi zambiri umakhala 500 kapena 850 mg, pafupipafupi makonzedwe amakhala kawiri pa tsiku. Mlingo wa insulin uyenera kusankhidwa potengera kuchuluka kwa shuga m'magazi.

Kwa ana kuyambira zaka 10, Glucofage imatha kutengedwa ngati monotherapy kapena nthawi imodzi ndi insulin. Mlingo woyamba umodzi nthawi zambiri umakhala wa 500 kapena 850 mg, pafupipafupi pakukhazikitsa - 1 nthawi patsiku. Kutengera ndende ya magazi pambuyo masiku 10-15, mlingo umatha kusintha. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Odwala okalamba ayenera kusankha mtundu wa metformin pang'onopang'ono pomuwonetsa mawonekedwe a impso (serum creatinine ayenera kutsimikizika osachepera 2-4 pachaka.

Glucophage imatengedwa tsiku ndi tsiku, popanda yopuma. Pambuyo pakutha kwa chithandizo, wodwalayo ayenera kudziwitsa dokotala za izi.

Mimba komanso kuyamwa

Matenda osawerengeka omwe ali ndi shuga panthawi yoyembekezera amawonjezera ngozi ya kubadwa kwa mwana wosabadwa ndi infinatal infa. Umboni woperewera kuchokera ku kafukufuku wazachipatala umatsimikizira kuti kutenga Metformin mwa odwala omwe ali ndi pakati sikungakulitse chiwopsezo chodziwika bwino mwa akhanda.

Pokonzekera kukhala ndi pakati, komanso ngati mimba imachitika pakumwa mankhwala a Glucofage ngati muli ndi matenda osokoneza bongo a prediabetes, mtundu wa mankhwala uyenera kuthetsedwa. Odwala omwe ali ndi matenda a shuga a 2 amapatsidwa mankhwala a insulin. Madzi a glucose a plasma amayenera kusungidwa pamlingo woyandikira kwambiri kuti achepetse chiopsezo cha kusokonezeka kwa kubereka kwa mwana wosabadwayo.

Metformin imatsimikiziridwa mu mkaka wa m'mawere. Zotsatira zoyipa za akhanda pakubwera pakumwa ma Glucofage sizinawoneke. Komabe, popeza chidziwitso chogwiritsira ntchito mankhwalawa m'gululi pakadali pano sichokwanira, kugwiritsa ntchito metformin panthawi yotsekemera sikulimbikitsidwa. Lingaliro la kusiya kapena kupitiriza kuyamwitsa limapangidwa pambuyo pabwino la kuyamwitsa ndi chiopsezo chotengera zovuta zomwe zimayambira khanda.

Kuyanjana kwa mankhwala osokoneza bongo

Glucophage sangagwiritsidwe ntchito nthawi imodzi ndi ma ayodini okhala ndi ayodini.

Mankhwala osavomerezeka kuti atengedwe limodzi ndi ethanol (chiwopsezo cha lactic acidosis kuledzera pachimake chimawonjezeka ngati chiwindi chikulephera, kutsata zakudya zopatsa mphamvu ndi kuperewera kwa zakudya m'thupi).

Chenjezo liyenera kumwedwa ndi glucofage ndi danazole, chlorpromazine, glucocorticosteroids ogwiritsa ntchito apakhungu ndi mwatsatanetsatane, ma "loop" okodzetsa, komanso ma beta2-adrenergic agonists ngati jakisoni.Kugwiritsa ntchito pamodzi ndi mankhwala omwe ali pamwambapa, makamaka kumayambiriro kwa chithandizo, kuwunika pafupipafupi magazi a glucose kungafunike. Ngati ndi kotheka, mlingo wa metformin panthawi ya chithandizo uyenera kusinthidwa.

Angiotensin-converting enzyme inhibitors ndi mankhwala ena a antihypertgency amatha kutsitsa magazi. Ngati ndi kotheka, kusintha kwa metformin ndikofunikira.

Ndi munthawi yomweyo kugwiritsa ntchito glucophage ndi acarbose, zotumphukira za sulfonylurea, salicylates ndi insulin, hypoglycemia imayamba.

Mankhwala a Cationic (digoxin, amiloride, procainamide, morphine, quinidine, triamteren, quinine, ranitidine, vancomycin ndi trimethoprim) kupikisana ndi metformin ya tubular transport system, yomwe ingayambitse kuwonjezeka kwa ndende yake yambiri (Cmax).

Ma Glucophage analogues ndi awa: Bagomet, Glucophage Long, Glycon, Glyminfor, Glformin, Metformin, Langerin, Metadiene, Metospanin, Siofor 1000, Formmetin.

Migwirizano ndi machitidwe osungidwa

Pewani kufikira ana pa kutentha mpaka 25 ° C.

• 500 ndi 850 mg mapiritsi - zaka 5,
• Mapiritsi a 1000 mg - zaka 3.

Ndi hyperglycemia, endocrinologists amakupatsani Glucofage 500 - malangizo ogwiritsira ntchito mankhwalawa amaphatikiza chidziwitso cha kudya kwake nthawi yomweyo ndi chakudya, kuti matenda a shuga akhale magazi. Katundu wa mankhwalawa kuti athane ndi mafuta adayambitsa kuti mankhwalawo adayamba kugwiritsidwa ntchito pakuchepetsa thupi. Onani zambiri za momwe mungachepetsere kulemera ndi mapiritsi awa, komanso momwe mungapangidwire kuchuluka kwa shuga m'magulu 2 a shuga.

Mapiritsi a Glucophage

Malinga ndi gulu la pharmacological, mankhwala a Glucofage ndi a gulu la othandizira pakamwa omwe amachepetsa shuga ya magazi mwa odwala omwe ali ndi matenda a shuga. Mankhwalawa ali ndi kulekerera kwabwino m'matumbo, chinthu chomwe chimapangidwira ndikupangidwa ndi metformin hydrochloride, yomwe ndi gawo la gulu la Biguanides (zomwe zimachokera).

Glucophage Long 500 kapena Glucophage 500 - awa ndiwo mitundu yayikulu yotulutsira mankhwala. Loyamba limadziwika ndi kuchitapo kanthu kwanthawi yayitali. Mapiritsi ena okhala ndi mitundu yosiyanasiyana ya metformin hydrochloride nawonso amakhala pawokha. Makonda awo:

The ndende ya yogwira thunthu, mg 1 pa pc.

500, 850 kapena 1000

Choyera, chozungulira (chozungulira cha 1000, cholemba)

Povidone, hypromellose, magnesium stearate, koyera opadra (hypromellose, macrogol)

Carlone sodium, magnesium stearate, hypromellose

10, 15 kapena 20 zidutswa pachimake

30 kapena 60 ma PC. mu paketi

Mankhwala a Glucophage a shuga

Mankhwalawa amathandizira chidwi cha insulin receptors ndikuthandizira kukonzanso shuga m'misempha, komwe kumapangitsa kutsika kwa shuga m'magazi. Izi zimathandiza kupewa hyperglycemia, yomwe itha kutsagana ndi matenda amtundu wa 2 shuga. A single (kwa Glucofage Long) kapena kawiri mlingo wa mankhwalawo amathandizira wodwala matenda ashuga.

Glucofage 500 yakuonda

Kuphatikiza popanga shuga m'magazi, Glucofage imagwiritsidwa ntchito pakuchepetsa thupi. Malinga ndi madotolo, ndikosayenera kumwa mapiritsi a anthu athanzi, chifukwa nthawi zambiri pamakhala kuwonetsa kosiyanasiyana. Mankhwala amachepetsa cholesterol yoyipa ndipo amatulutsa matenda a metabolism mwa odwala matenda ashuga okha. Ena samvera zonena za madokotala ndipo amamwa mapiritsi azakudya. Poterepa, kufunsira ndikutsatira malangizowo ndikufunika:

• kumwa mlingo wa 500 mg musanadye katatu patsiku, mlingo waukulu wa metformin tsiku lililonse ndi 3000 mg,
• Ngati mulingo wambiri (chizungulire ndi mseru zimawonedwa), muchepetse ndi theka.
• Maphunzirowa atenga masiku 18-22, mutha kubwereza mlingo pambuyo miyezi ingapo.

Momwe mungatenge Glucophage

Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa Glucophage amatengedwa pakamwa.Kwa achikulire, mlingo woyambirira wa monotherapy ndi 500 mg kapena 850 mg 2-3 kawiri pa tsiku mukatha kudya kapena nthawi yomweyo. Mlingo wokonza ndi 1500-2000 mg patsiku, womwe umagawidwa pazigawo zitatu, ndipo kuchuluka kwa tsiku lililonse ndi 3000 mg. Akaphatikizidwa ndi insulin, mlingo woyambirira ndi 500-850 mg 2-3 kawiri pa tsiku.

Kwa ana opitilira zaka zopitilira 10, mlingo woyambirira ndi 500-850 mg kamodzi patsiku pambuyo chakudya kapena pakudya. Pambuyo masiku 10-15, mlingo umasinthidwa, pazofika tsiku lililonse ndi 2000 mg mumagawo awiri. Mwa anthu achikulire, chifukwa cha kuchepa kwa ntchito ya impso, mlingo umatsimikiziridwa kutengera zomwe zili serum creatinine. Mankhwala Glucofage Akuluakulu opitirira 18 amatenga kamodzi patsiku chakudya chamadzulo, mlingo woyambirira ndi piritsi 1, pambuyo masiku 10-15 amasinthidwa kukhala 1.5 g (mapiritsi 2) kamodzi / tsiku. Ngati izi sizokwanira, mpesa wokwanira ukhale 2.25 g (mapiritsi atatu) kamodzi patsiku.

Glucophage pa nthawi yapakati

Kugwiritsa ntchito mankhwalawa kumayesedwa panthawi yomwe muli ndi pakati, koma, malinga ndi ndemanga zochepa za amayi apakati, komabe amakakamizidwa kuti amwe, palibe chitukuko cha zolakwika zatsopano mwa akhanda. Mukakonzekera kutenga pakati kapena pakachitika, chithandizo chamankhwala chikuyenera kutha, insulini iyenera kutumizidwa. Metformin amamuchotsa mkaka wa m'mawere;

Kuyamwa kwa mowa

Kuphatikizidwa komwe kumaphatikizidwa ndi kuphatikiza kwa glucophage ndi mowa. Ethanol mu zakumwa zoledzeretsa zam'mimba zimawonjezera chiopsezo cha lactic acidosis, yomwe imalimbikitsidwa ndi zakudya zama calorie ochepa, zakudya zama calorie ochepa, komanso kulephera kwa chiwindi. Munthawi yonse ya chithandizo chamankhwala, zakumwa zokhala ndi zakumwa zoledzeretsa ndi mankhwala, zakumwa zaukali ziyenera kupewedwa.

Migwirizano yogulitsa ndikusunga

Glucophage ikhoza kugulidwa kokha ndi mankhwala. Mankhwalawa amasungidwa kutali ndi ana m'malo amdima pa kutentha mpaka madigiri 25, moyo wa alumali ndi zaka 3-5, kutengera kuchuluka kwa metformin hydrochloride pamapiritsi.

Pali mitundu ingapo yachindunji ndi yosatchulika ya Glucofage. Zoyambazo zikufanana ndi mankhwalawa pophatikizika ndi zomwe zimagwira, zomwe zimatengera zomwe zimawonetsedwa. Patsamba lazamankhwala mumatha kupeza zotsatirazi zamafuta omwe amapangidwa m'mafakitale ku Russia ndi mayiko ena:

Mtengo Glucofage 500

Mutha kugula mankhwalawa kudzera pa intaneti kapena m'madipatimenti opanga mankhwala pamtengo, momwe mumakhudzidwira ndi malonda, kuchuluka kwa zinthu zogwiritsidwa ntchito pamapiritsi, kuchuluka kwake phukusi. Mitengo yoyandikira ya mapiritsi idzakhala:

Kukumana kwa metformin hydrochloride, mg

Chiwerengero cha mapiritsi pa paketi iliyonse

Mtengo wa intaneti, ma ruble

Mtengo wa mankhwala mu ruble

Hypoglycemic wothandizila kukonzekera pakamwa pa gulu la Biguanide. Glucophage imachepetsa hyperglycemia, popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zomwe zimachokera ku sulfonylurea, sizimalimbikitsa insulin komanso sizikhala ndi vuto pakati pa anthu athanzi.
Glucophage imawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Amalepheretsa gluconeogenesis m'chiwindi. Iachedwetsa kuyamwa kwa mafuta m'matumbo. Kuphatikiza apo, ili ndi phindu pa metabolidi ya lipid: imatsitsa cholesterol yathunthu, LDL ndi TG.
Pambuyo pakulowetsa, metformin imatengedwa kuchokera m'matumbo am'mimba kwathunthu, ndowe, 20-30% ya mlingo wotengedwa umachotsedwa. Mtheradi bioavailability kuchokera 50 mpaka 60%. Ndi kuyamwa kwa munthawi yomweyo, kuyamwa kwa metformin kumachepa ndikuchepera. Metformin imagawidwa mwachangu mu minofu, sikuti imagwira mapuloteni a plasma. Mu thupi, metformin imapangidwira pang'ono kwambiri ndipo imatuluka mkodzo. Kuvomerezeka kwa anthu athanzi ndi 440 ml / min (kutalika kanayi kuposa kwa creatinine), zomwe zimawonetsa kukhalapo kwa katulutsidwe ka njira yogwira. Hafu ya moyo pafupifupi maola 9-12.Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kukopeka kwa mankhwalawa.

Kugwiritsa ntchito mankhwala Glucofage

Mlingo wa mankhwalawa umakhazikitsidwa ndi adokotala payekha, kutengera kuchuluka kwa shuga m'magazi. Mlingo woyambirira wa akuluakulu ndi 500-1000 mg / tsiku. Pambuyo masiku 10-15, kuwonjezeranso pang'onopang'ono kwa mlingo kumatheka kutengera mtundu wa glycemia. Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Mlingo waukulu kwambiri ndi 3000 mg / tsiku. Kuchepetsa pafupipafupi mavuto obwera chifukwa cha m'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa pawiri.
Mapiritsi ayenera kumwedwa osatafuna nthawi yakudya kapena itatha. Kutalika kwa chithandizo kumatengera kuuma ndi chikhalidwe cha matendawa.

Contraindging kugwiritsa ntchito mankhwala Glucofage

• matenda ashuga ketoacidosis, matenda a shuga, chikomokere,
• kuwonongeka kwaimpso,
• matenda pachimake ndi chiwopsezo cha matenda aimpso: kuchepa magazi (ndi m'mimba, kusanza), kutentha thupi, matenda opatsirana, hypoxia (mantha, sepsis, matenda a impso, matenda a bronchopulmonary),
• mwaukadaulo owonetsa matenda owopsa komanso osachiritsika omwe angayambitse kukula kwa minofu hypoxia (mtima kapena kupuma, kulephera kwamkati, ndi zina zotere),
• opaleshoni yayikulu ndi zoopsa (pamene chithandizo cha insulin chikusonyeza),
• chiwindi ntchito,
• uchidakwa wambiri, chakumwa chakumwa choledzeretsa,
• Mimba ndi kuyamwa
• Hypersensitivity mankhwala
• lactic acidosis (kuphatikizapo mbiri ya)
• gwiritsani ntchito kwa masiku osachepera a 2 musanayambe ndi masiku awiri mutachitika maphunziro a radioisotope kapena radiology pokhazikitsa ayodini wokhala ndi zosiyana pakati,
• kutsatira zakudya zochepa zama calori (zosakwana 1000 calories / tsiku).

Glucophage - mapiritsi azakudya

Mankhwalawa, omwe adalola anthu kupitilira 40% kuchepetsa kufa kwa matenda ashuga, amapezeka mu mawonekedwe a mapiritsi, atapangidwa m'matumba a zidutswa 10, 15 ndi 20. Piritsi limodzi limatha kukhala ndi 500, 850 kapena 1000 mg ya mankhwala othandizira, omwe ndi metformin hydrochloride. Imwani glucophage katatu patsiku musanadye.

Mapiritsi a Glucophage ali ndi mitundu iwiri ya Mlingo, wokhazikika komanso glucophage nthawi yayitali. Mapiritsi awa oblong amatha kukhala ndi 500 ndi 850 mg ya mankhwala othandizira ndipo amawaika m'matumba a 30 ndi 60 zidutswa. Kusiyanitsa kwa glucophage wautali ndi wabwinobwino ndikuti njira yonyamula yomwe ilipo imachepetsedwa, chifukwa chake amafunika kutengedwa popanda kutafuna, kamodzi kapena kawiri patsiku ndikudya.

Momwe ma glucophage amakhudzira thupi panthawi yakuonda

Kulandila kwa glucophage kumayendetsa njira ya oxidation yamafuta acids ndikuchepetsa kuyamwa kwa mafuta omwe amalowa mthupi ndi chakudya, komanso kutsitsa insulin. Chifukwa cha kuchuluka kwa insulini, zopatsa mphamvu zimayikidwa mu mafuta osungidwa. Kutsika kwa insulin yopangidwa ndi kapamba kumachitika chifukwa cha kuchepa kwa glucose wamagazi ophatikizidwa ndi metmorphine. Mankhwalawa nthawi imodzi ndi kuchuluka kwa insulin amachepetsa ndikumverera kwanjala, chifukwa chake iwo omwe amamwa mankhwalawa amayamba kudya zochepa. Kuphatikiza apo, kubwezeretsa metabolism ndikuchepetsa kupanga insulin ndi shuga m'magazi pazikhalidwe zabwino, glucophage imangolimbikitsa kuchepa thupi, komanso kuchuluka kwa cholesterol.

Kafukufuku wasonyeza kuti kugwiritsa ntchito bwino kwa mankhwalawa kumachepa ndi kuwonjezereka kwa acidity, komanso kugwiritsa ntchito mafuta "othamanga" komanso maswiti. Chifukwa chake, phwando la glucophage liyenera kuphatikizidwa ndi zakudya zapadera.

Gwiritsani ntchito paubwana

Mwa ana a zaka zapakati pa 10 ndi kupitirira, Glucophage ingagwiritsidwe ntchito ngati monotherapy komanso kuphatikiza insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi / tsiku mukatha kudya kapena pakudya.Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Gwiritsani ntchito mu ukalamba

Chifukwa cha kuchepa kwa ntchito ya impso mu okalamba, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa zomwe zili serum creatinine osachepera 2-4 pachaka). Mosamala, mankhwalawa amayenera kugwiritsidwa ntchito mwa odwala azaka zopitilira 60 akugwira ntchito yolimbitsa thupi (yomwe imalumikizidwa ndi chiwopsezo chokhala ndi lactic acidosis mwa iwo).

Migwirizano ndi magwiritsidwe akusungidwa

Mankhwalawa amayenera kusungidwa kuti ana asawatenthe pa kutentha osaposa 25 ° C. Alumali moyo mapiritsi a 500 mg ndi 850 mg ndi zaka 5. Moyo wa alumali wa mapiritsi a 1000 mg ndi zaka zitatu.

Wopanga: Nycomed Austria GmbH (Nycomed Austria GmbH) Austria

Code PBX: A10BA02

Fomu yotulutsidwa: Ma fomu a Mlingo wolimba. Mapiritsi

Makhalidwe

Pofuna kumvetsetsa dongosolo lamitengo ya mankhwalawa, chidziwitso chinagwiritsidwa ntchito kuchokera ku imodzi mwa malo ogulitsa pa intaneti omwe ali ku Moscow.

Wopanga "Nycomed" amayimilidwa, koma mitengo yochokera kuzomera zina imasiyana pang'ono.

Dzinalo	Wopanga	Mlingo	Chiwerengero cha makapisozi pa paketi iliyonse	Mtengo (ma ruble)
Mapiritsi a Glucofage	Wodandaula	500 mg	30	127,00
		850 mg	30	131,00
		1000 mg	30	192,00
		500 mg	60	170,00
		850 mg	60	221,00
		1000 mg	60	318,00

Mapeto osavuta amadzisonyeza kuchokera pagome kuti chidacho ndi chotsika mtengo. Palibe mavuto ndi kupezeka kwa mafakitala mwina.

Kuchita ndi mankhwala Glucofage

Kugwiritsa ntchito nthawi yomweyo danazol osavomerezeka kuti apewe mphamvu yake. Ngati mankhwala a danazol akufunika ndipo atayimitsa, kusintha kwa glucofage kumafunikira motsogozedwa ndi glucose level. Kumwa mowa mwauchidakwa kumawonjezera mwayi wokhala ndi lactic acidosis panthawi yoledzera ya pachimake, makamaka ngati akusala kapena kutsatira zakudya zochepa zopatsa mphamvu, komanso ngati chiwindi chikulephera. Mukamamwa mankhwalawa, muyenera kupewa kumwa mowa komanso mankhwala omwe ali ndi mowa.
Kuphatikiza komwe kumafunikira chisamaliro chapadera:
Chlorpromazine: Mukamamwa mankhwala waukulu (100 mg patsiku) amawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kutulutsa kwa insulin. Mankhwala a antipsychotic ndipo atayimitsa makonzedwe awo, kusintha kwa Glucofage kumafunika muulamuliro wa glycemia.
GKS mwatsatanetsatane komanso kwawoko kuchepetsa kulolera kwa glucose, kuonjezera glycemia, nthawi zina kuyambitsa ketosis. Mankhwalawa corticosteroids ndipo atayimitsa kudya kwa chakumapeto, kusintha kwa mlingo wa Glucofage kumafunikira motsogozedwa ndi gawo la glycemia.
Zodzikongoletsera : munthawi yomweyo kugwiritsa ntchito malupu okodzetsa kungayambitse kukulitsa kwa lactic acidosis chifukwa chotheka kugwira ntchito kwaimpso. Glucophage sayenera kufotokozedwa ngati mulingo wa creatinine m'magazi ndiwoposa 135 μmol / L mwa amuna ndi 110 μmol / L mwa akazi.
Ma ayodini okhala ndi ayodini : kafukufuku wama radiology ogwiritsa ntchito ayodini wokhala ndi ma radiopaque othandizira amatha kuyambitsa lactic acidosis kwa odwala omwe ali ndi matenda osokoneza bongo motsutsana ndi maziko a kulephera kwa impso. Glucophage iyenera kuyimitsidwa mkati mwa maola 48 ndipo osayambiranso kugwiritsidwa ntchito masiku awiri atangoyesedwa ndi X-ray pogwiritsa ntchito ma radiopaque othandizira.
Mitundu yolowetsedwa β 2amphanomachul : onjezani shuga wamagazi chifukwa chokondoweza kwa β2 zolandilira. Pankhaniyi, kuyang'anira glycemic ndikofunikira. Ngati ndi kotheka, insulin ikulimbikitsidwa. Ndi munthawi yomweyo kugwiritsa ntchito glucophage ndi sulfonylurea zotumphukira, insulin, acarbose, salicylates, ndizotheka kuwonjezera mphamvu ya hypoglycemic.

Mankhwala osokoneza bongo Glucofage, Zizindikiro ndi mankhwala

Mukamagwiritsa ntchito Glucophage muyezo wa 85 g, palibe chitukuko cha hypoglycemia, koma pamenepa lactic acidosis idayamba.Zizindikiro zoyambirira za lactic acidosis ndi mseru, kusanza, kutsegula m'mimba, kutentha thupi, kupweteka m'mimba, kupweteka kwa minofu, mtsogolomo kumawonjezera kupuma, chizungulire, chikumbumtima chodwala komanso kukula kwa chikomokere.
Chithandizo: ngati zizindikiro za lactic acidosis, chithandizo cha Glucofage ziyenera kuyimitsidwa nthawi yomweyo, wodwalayo amayenera kugonekedwa kuchipatala mwachangu ndipo atatsimikiza kuchuluka kwa lactate, kufotokozera kuyenera kumveka bwino. Njira yothandiza kwambiri yochotsa lactate ndi Glucophage kuchokera mthupi ndi hemodialysis. Chithandizo cha Zizindikiro zimachitidwanso.

Kufotokozera za mtundu wa kipimo

500 ndi 850 mg mapiritsi: yoyera, yozungulira, ya biconvex, yokhala ndi mafilimu, pamtanda - yopanda choyera.

Mapiritsi a 1000 mg: yoyera, chowulungika, biconvex, yokutidwa ndi membala wamakanema, wokhala ndi notch mbali zonse ziwiri ndikujambula "1000" mbali imodzi, pamtanda wamtanda - misa yayikulu yoyera.

Ndemanga kumwa mankhwala

Palibe maphunziro a sayansi pazotsatira za mankhwalawa pazowonda.

Chifukwa chake, chikungoganizira pazowunikira anthu omwe amamwa mapiritsiwo.

Mnzathu adalimbikitsa kuyesera Glucofage kuti achepetse thupi. Kulemera kwake kunali pafupifupi ma kilogalamu 80, pamlingo wa 60. Adanenanso kuti sabata iliyonse amatenga 2-3 kilos. Adatenga milungu itatu. Ndili ndi ma kilogalamu 74, koma ndimafuna zochepera 60, ndiye kuti, sindimadwala matenda onenepa kwambiri, koma ndimankhwala ochepa.

Zakudya zam'magazi zotere sizothandiza kwenikweni, choncho ndidaganiza zoyesera. Masiku oyamba amabwera nseru, koma zidutsa. Anamva kuchepa kwa chikhumbo, makamaka chosangalatsa ndi kusowa kwachisawawa chokaponya kanthu pakamwa pake patangotha ​​madzulo.

Ndakhala ndikumwa mapiritsi kwa milungu iwiri ndipo ndatsitsa ma kilogalamu atatu, zomwe zimandisangalatsa kwambiri. Ndikupangira!

Ndi kuwonjezeka kwa masentimita 165 kulemera pafupifupi kilogalamu 100. Ndinawerenga ndemanga ndipo ndidaganiza zoyesa Glucofage. Sindinamve zowawa zilizonse, koma patatha milungu itatu sindinalandirepo.

Anzake adapereka chopondera, ndimathamanga makilomita awiri patsiku kwa ma kilomita awiri, katatu pa sabata, ndinayima kuwuka usiku mufiriji ndipo kulemera kunayamba kuchepa! Osakhulupirira mapiritsi ozizwitsa, maphunziro akuthupi okha komanso zakudya zabwino.

Ndisanamwa mankhwalawa, ndinalemera ma kilogalamu 124 ndikuwonjezeka kwa 170. Ndakhala ndikumwa mapiritsi pafupifupi miyezi isanu ndi umodzi (mwachidziwikire, ndikusokoneza). Tsopano mapaundi 92. Sindikukumbukira zovuta zilizonse (nseru, ndi zina). Sindinagwiritse ntchito chilichonse chokoma m'mwezi woyamba ndi theka kwina. Tsopano ndimalola kuti ndizilowa nthawi zina.

Adayamba kuthamanga pang'ono ndikumpopa (khungu limayamba kuguguda). Sindikudziwa chomwe chinandithandiza - chakudya chomwe ndimakhala ndi maphunziro olimbitsa thupi kapena mapiritsi, koma zimachitika.

Kupsinjika kwakanthawi ndimatsutso kumabweretsa kunenepa kwambiri (kuthinana, monga ambiri). Moyo unayamba kuyenda pang'onopang'ono, ndipo mapaundi owonjezerawa adatsalira. Zakudya zamagetsi ndi zida zolimbitsa thupi si zanga, chifukwa chake ndidasankha kuyesa Glucofage. Ndinkamwa maphunziro awiri ndikusiya zovala zazikulu ziwiri. Tsopano sindikuvomereza, koma kulemera kwakhazikika. Sindinamvepo zowawa zilizonse, komanso zovuta zaumoyo.

Mapiritsi a Glucophage adalembedwa ndi endocrinologist. Pakadali pano ndakhala ndikumawatenga kwa milungu iwiri. Ndinayamba ndi ma milligram 500, tsopano ali ndi 1000. Masiku awiri oyambilira ndinali ndimiseche pang'ono ndipo ndimakonda kupita kuchimbudzi. Tsopano zonse zikuwoneka kuti zakhazikika.

Zotsatira zake lero ndi ma kilogalamu ochepa mu ofiira, koma kuweruza ndi zovala, mavoliyowo ayamba kuchoka. Izi ndizosangalatsa, kale kuti panali zaka zolimbana ndi kunenepa kwambiri, koma palibe zotsatira zooneka.

Ndani adasankha kugwiritsa ntchito mankhwalawa, ndikukulangizani kuti musachite manyazi ndikuwonana ndi dokotala. Adotolo adandinyamula tchati, adandiyesa matenda amtima ndi impso, amafunika mayeso a shuga wamagazi.

Palibe zakudya zapadera, kunali kofunikira kupatula zotsekemera ndi ufa (tiyi wopanda supuni ya shuga sawerengera), sindimamwa zakumwa zochokera kaboni. Kuyambira pamasewera - kuyenda kwakutali mlengalenga, koma ndidayesetsa kuchita izi m'mbuyomu.Ndikuyiyikira kwambiri!

-Tatyana N., wazaka 37

Ndimatenga kuti kumwa mapiritsi a matenda ashuga popanda matendawa kulibe. Mankhwalawa amachepetsa kuyamwa kwa shuga m'matumbo am'mimba, omwe m'nthawi yochepa amatha kutsika. Koma!

1. Kuperewera kwa shuga kumapangitsa kuti thupi liyambe kudzipanga lokha. Nthawi yomweyo, imanyamulidwa kupita ku minofu minofu. Kuchotsa zochuluka kumatheka pokhapokha mothandizidwa ndi kulimbitsa thupi kwambiri. Zotsatira zake, pali kudzikundikira kwa lactic acid, komwe kumabweretsa matenda oopsa - lactic acidosis.
2. Kuphatikiza kosavuta pokwaniritsa zotsatira zoyambirira (kuwonda pang'ono) kumabweretsa kuti munthu amasiya kuwunika zakudya komanso moyo wabwino. Kupatula apo, ndikosavuta kugula mapiritsi, kutsatira zakudya zosavuta. Koma kudya pafupipafupi glucophage ndi munthu wathanzi posachedwa kumayambitsa zovuta za metabolic. Ndipo iyi ndi nkhani yovuta kwambiri.

Sergey Nikolaevich, dokotala - endocrinologist

Glucophage imatha kuperekedwa kwa anthu odwala matenda ashuga. Koma pokhapokha ngati pali kupatuka kwazinthu zonse malinga ndi kuchuluka kwa insulin. Mankhwala amathana ndi ntchito yake, ndipo kuchuluka kwa mahomoni amabwerera kwazonse.

Zotsatira zake, kagayidwe kamayenda bwino ndipo njira yochepetsera thupi imachitika. Koma iyi si ntchito yachindunji, koma zotsatira zakapangidwe kazomwe zimachitika mkati. Ngati palibe zizindikiro zamankhwala zakuti mutenge, simungamwe mapiritsi.

-Elena S., endocrinologist

Zomwe muyenera kudziwa za Glucofage zikufotokozedwa mu kanema.

Glucophage kwa nthawi yayitali amakhala m'malo ofunikira kwambiri kupewa ndi kupewa matenda a shuga a 2, amagwiritsidwa ntchito pakuchepetsa thupi komanso kupewa matenda a mtima. Ndi mankhwala oyamba a metformin ndipo amalembedwa ndi ambiri omwe amatsatira ma endocrinologists ku Russia.

Ndikofunikira kudziwa! Nkhani yatsopano yomwe ikulangizidwa ndi ma endocrinologists a Kuwunika Kwachisawawa Kokulu! Ndi zofunika tsiku lililonse.

Mu 2016 Glucophage adalandira mphotho yamankhwala mu kusankha "Mankhwala osankhidwa". Piritsi imapangidwa ndi kampani yakale kwambiri yasayansi komanso tekinoloje Merck. Ngakhale mbiri yake yazaka mazana atatu, tsopano ndi imodzi mwazomwe akupanga mankhwala padziko lapansi. Zinthu zonse za kampaniyo, mosasamala malo omwe amapangidwira, zimayang'anira chitetezo chamitundu yambiri.

Zakudya zamagulu owonjezera zama glucofage kuti muchepetse kunenepa

Kuti mukwaniritse cholinga chanu ndikutaya mapaundi owonjezera, kudya glucophage, muyenera kutsatira chakudya chokwanira komanso osapatula zakudya zomwe zimakonzedwa zomanga thupi "mwachangu". Mutha kumamatira ku chakudya chamagulu ndikuchepetsa kuchuluka kwa zopatsa mphamvu, kapena gwiritsani ntchito zakudya zopanda mafuta zomwe zimaphatikizapo chakudya "chovuta" chochuluka komanso kupatula kudya kwa lipid.

Muziphatikizo zanu zakudya zomwe zili ndi fiber yambiri: tirigu ndi buledi, masamba, ndi nyemba. Mbatata zokhala ndi wowuma, shuga, uchi, komanso zipatso zouma, nkhuyu, mphesa ndi nthochi, sizimachotsedwa kwawanthu.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

Matenda a shuga ndi omwe amayambitsa pafupifupi 80% yonse yamikwingwirima ndi kuduladula. Anthu 7 mwa anthu 10 amafa chifukwa cha mitsempha ya mtima kapena ubongo. Pafupifupi nthawi zonse, chifukwa chomaliza chomaliza ndi chimodzimodzi - shuga wamwazi.

Shuga akhoza ndipo ayenera kugwetsedwa; Koma izi sizichiritsa matendawa, koma zimangothandiza kulimbana ndi kufufuza, osati zomwe zimayambitsa matendawa.

Mankhwala okhawo omwe amalimbikitsidwa moyenera pochiza matenda ashuga komanso amagwiritsidwa ntchito ndi ma endocrinologists pantchito yawo ndi awa.

Kugwiritsa ntchito bwino kwa mankhwalawa, kuwerengera malinga ndi njira yokhazikika (kuchuluka kwa odwala omwe achiwonjezere kuchuluka kwa odwala omwe ali mgulu la anthu 100 omwe adachitiridwa chithandizo):

• Matenda a shuga - 95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu - 90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kulimbitsa tsiku, kukonza kugona usiku - 97%

Opanga si bungwe lazamalonda ndipo amalipidwa ndi chithandizo cha boma. Chifukwa chake, tsopano wokhala aliyense ali ndi mwayi.

Glucophage analogues

Kuphatikiza pa Glucofage, mankhwala ochulukirapo ambiri okhala ndi metformin yogwira ntchito amapangidwa padziko lapansi. Zonsezi ndizopanga zamagetsi: zopangidwa molingana ndi ukadaulo wofanana, zimayenderana. Mapangidwe a zigawo zothandizira, mawonekedwe a piritsi, kuchuluka kwa kuyeretsa kumatha kusiyanasiyana. Nthawi zambiri mankhwala oyambira amakhala okwera mtengo kwambiri kuposa ma jeniki. Kwa ife, kusiyana kwa mtengo ndikosafunikira, Glucophage imatengera ndalama zambiri ngati European ndi Russian analogues ya mankhwala. Cheaper yekha wotsika kwambiri Indian ndi Chinese metformin. Ngati pali chosankha, ndibwino kugula Glucophage, chifukwa mankhwalawo oyamba nthawi zonse amakhala otetezeka kuposa ma analogues.

Zotheka kusintha:

• Bagomet,
• Metfogamma,
• Metformin teva
• Glyformin
• NovoFormin,
• Siofor
• Fomu.

Metformin imapangidwa pamodzi ndi zinthu zina: rosiglitazone (Avandamet), glibenclamide (Bagomet Plus, Glibomet, Glukovans), vildagliptin (Galvus Met), glyclazide (Glimecomb). Simungathe kuwachotsa ndi Glucophage , popeza zomwe akuwonetsa komanso Mlingo omwe ali nawo ndi zosiyana.

Glucophage kapena Siofor

Siofor ndiye kholo la kampani yaku Germany Berlin-Chemie, mpikisano waukulu wa Glucofage. Kusiyana kwa mankhwala:

1. Chifukwa cha ndondomeko ya wopanga, Siofor nthawi zambiri amalembera anthu omwe ali ndi metabolic syndrome kuti achepetse thupi.
2. Maphunziro a chitetezo ndi luso anali kuchitidwa kokha ndi oyambirirawo.
3. Siofor adayesedwa kokha kuti apeze bioequivalence ndi Glucofage.
4. Mankhwala osokoneza bongo amasiyana pang'ono pakupanga kwa zinthu zofunika kupanga piritsi.
5. Siofor alibe mawonekedwe atali.

Ndemanga za odwala matenda ashuga za mankhwalawa ndizosiyana. Odwala ena amati Siofor amalekeredwa bwino, ena akutsimikiza kuti Glucofage ndiyabwino. Enanso samawona kusiyana kulikonse ndikugula mapiritsi omwe ali mufiriji yapafupi.

Zokhudza impso ndi chiwindi

Popeza glucophage amathandizidwa ndi impso, kayendetsedwe ka ntchito zawo ndikofunikira pakukhazikitsa. Kuti muchite izi, ndikofunikira kuti onse odwala matenda ashuga azitha kuyesa mkodzo ndi magazi chaka chilichonse. Okalamba, odwala matenda a shuga a nephropathy, ogwiritsira ntchito mankhwalawa kwa nthawi yayitali kukakamiza, okodzetsa, NSAIDs - patatu. Metformin ilibe vuto pa impso. M'malo mwake, kuteteza zombo, kumachepetsa chiopsezo cha nephropathy.

Glucophage imalimbikitsidwa kuti muchepetse kunenepa kwambiri mwa anthu omwe ali ndi vuto logona m'mimba kwambiri, lomwe limatsimikiziridwa ndi hyperinsulinemia (yotsimikiziridwa ndi kapena), "nkhandwe" yosalamulira. Kulandila kuyenera kuphatikizidwa ndi chakudya cha 1200 kcal. Udindo wa Glucophage ndi kukankhira njira yochepetsera thupi, popanda kusintha mphamvu kulibe mphamvu. Malinga ndi ndemanga, pa metformin yopanda chakudya, simungataye kuposa 3 kg. Ngati kunenepa kwambiri kumayambitsidwa chifukwa cha kudya komanso zizolowezi zolakwika, kukana insulini kulibe kapena kopanda tanthauzo, mankhwalawa sangathandize.

Kuti mutenge molondola Glucophage ndi fanizo la kuchepa thupi, muyenera kuwerenga malangizo a anthu odwala matenda ashuga. Ngakhale shuga atakhala wabwinobwino, mankhwalawa aledzera muyeso womwewo: yambani ndi 500 mg ndikuwonjezera pang'onopang'ono mapiritsi anu muyeso wabwino.

Glucophage kuchokera ku ukalamba

Pakadali pano, zolemba zokhudzana ndi mitundu yapadera ya metformin zimapezeka kwambiri m'mabuku azachipatala. Amaganizira kuti amalepheretsa kukalamba, kusokoneza thupi kwathunthu:

• imapangitsa kukula kwa mitsempha,
• imathandizira kubwezeretsa minofu yamitsempha,
• Amathandizanso kuonetsa ziwopsezo zambiri za matenda amisempha,
• imachepetsa kutupa,
• amateteza mtima ndi mitsempha yamagazi,
• amachepetsa chiopsezo cha oncology,
• kuchuluka mphamvu,
• bwino potency
• kuchedwetsa mafupa
• kumalimbitsa chitetezo chathupi.

Mwachidule, mapiritsi a Glucophage amaikidwa ngati mankhwala padziko lonse lapansi pamavuto onse okalamba.Zowona, maphunziro odalirika sanatchulidwe, kotero pakadali pano maloto chabe amtsogolo osangalatsa popanda kukalamba.

Zisonyezero za mankhwala Glucofage ®

lembani matenda a shuga 2, makamaka odwala kunenepa kwambiri, omwe samachita bwino pakudya ndi masewera olimbitsa thupi:

Akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa kapena ma insulin,

Mwa ana kuyambira zaka 10 monga monotherapy kapena osakanikirana ndi insulin,

kupewa mitundu yachiwiri ya matenda a shuga a odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka cha mtundu 2 wa matenda a shuga, momwe kusintha kwasinthidwe sikunalole kukwaniritsa kuyenera koyenera kwa glycemic.

Momwe mungatengere glucophage kuti muchepetse kunenepa

Tengani 500 mg glucophage kuwonda katatu patsiku musanadye. Ngati muli ndi zotayirira zotayidwa, izi zitha kukhala chifukwa cha mafuta ochulukirapo. Ngati nseru ikuwoneka, mlingo wa mankhwalawa umayenera kuchepetsedwa 2 times. Glucophage iyenera kumwedwa mosapitilira milungu itatu. Kuphatikiza zotsatilapo pambuyo pa masabata 6-8, maphunzirowa atha kubwerezedwa.

Kupititsa patsogolo kufupika kwa glucophage, pangani kuwongolera pafupipafupi, kuwonongeratu mphamvu zolimbitsa thupi

Malamulo Ovomerezeka

Lamulo lofunikira lotenga Glucophage ndikuwonjezera pang'onopang'ono kwa mlingo. Mlingo woyambira ndi 500 mg. Amamwa mpaka milungu iwiri, uku akulamulira glycemia. Mwazi wamagazi panthawiyi uyenera kuchepa pang'onopang'ono. Masiku onse 10 mpaka 10, mlingo umakulitsidwa ndi 250-500 mg mpaka zolinga za shuga zitheke.

Kutalika kwa mankhwala

Ngati zikuwonetsedwa, nthawi ya chithandizo ndi Glucofage ndi yopanda malire. Pomwe mankhwalawa akugwira ntchito, muyenera kupitiliza kuumwa. Mukasiya kwakanthawi pang'ono, kuwonongeka kwa matenda ashuga kumachitika. Poyerekeza ndemanga za odwala, ndikotheka kukana mapiritsi osowa kwambiri, ngati wodwala yemwe ali ndi matenda oyamba omwe amadwala matenda ochepa a carb, amachita masewera olimbitsa thupi pafupipafupi ndipo amatha kuthana ndi kunenepa kwambiri. Ngati cholinga chofuna kudya chinali kutsika thupi, mutha kuletsa metformin mutangofika muyezo womwe mukufuna.

Kufooka

Ndi matenda a shuga, mlingo wosaposa 2000 mg ndi wabwino. Kusinthana ndi kuchuluka kwa mlingo kumawonjezera chiopsezo cha mavuto, koma pang'ono pa glycemia. Kuchulukanso kwina kwa mankhwalawa sikuthandiza komanso kupundana ndi lactic acidosis.

Mlingo wosinthidwa ukhoza kuchuluka pakapita nthawi. Izi sizikusonyeza kusuta, koma kusintha kwa matendawo kukhala gawo lina. Ndi shuga wambiri, kapamba amatuluka msanga, ndi metformin, mumayenera kumwa mapiritsi owonjezera a shuga, kenako ndi insulin. Kuti muchepetse kaphatikizidwe ka insulin yanu, muyenera kutsatira mosamala chithandizo chomwe mumalandira, kuphatikizapo masewera ndi zakudya.

Kukonzanso zakudya

Mapiritsi a Glucophage amagwira ntchito limodzi kuphatikiza ndi zakudya. Anthu odwala matenda ashuga nthawi zonse amakhala ochepetsedwa ndi chakudya pang'ono komanso osakhalitsa othamanga. Chiwerengero cha shuga pang'onopang'ono chololedwa tsiku lililonse chimatsimikiziridwa ndi adokotala. Zakudya zochepetsetsa kwambiri, zimalola mafuta okwana 300 g patsiku. Zovuta kwambiri ndizopendekera zotsika kwambiri zomwe zimakhala ndi malire mpaka 100 g ndi pansi. Mulimonsemo, chakudya chimayenera kukhala chamagulu azakudya zomanga thupi komanso zobiriwira. Chakudya chimayenera kudyedwa nthawi 5-6, zakudya zimagawidwa chimodzimodzi tsiku lonse.

Piritsi limodzi lili:

Zogwira pophika: metformin hydrochloride - 500/850/1000 mg,

Zosakaniza zothandizira: povidone 20/34/40 mg, magnesium yothira 5.0 / 8.5 / 10.0 mg. Filamu wachimvekere:

Mlingo 500 mg ndi 850 mg: hypromellose 4.0 / 6.8 mg.

Mlingo wa 1000 mg: Opadry net 21 mg (hypromellose 90.90%, macrogol 400 4.550%, macrogol 8000 4.550%).

Mlingo 500 mg, 850 mg:
Mapiritsi oyera, ozungulira, a biconvex.
Mlingo wa 1000 mg:
Masamba oyera, ozungulira, mapiritsi a biconvex, ophatikizidwa ndi mafilimu, omwe ali pachiwopsezo mbali zonse ziwiri ndipo adalemba "1000" mbali imodzi.
Gawo la mtanda likuwonetsa yunifolomu yoyera.

Mimba komanso kuyamwa

Matenda a shuga omwe sanakulipiridwe panthawi yomwe ali ndi pakati amaphatikizidwa ndi chiwopsezo chowonjezeka cha zilema zakubadwa ndi kufa kwa perinatal. Zambiri zowerengeka zikusonyeza kuti kutenga metformin mwa amayi apakati sikuti kumawonjezera vuto la kubereka mwa ana.

Pokonzekera kutenga pakati, komanso pathupi panu mukumwa Metformin, mankhwalawa ayenera kusiyidwa, ndipo mankhwala a insulin ayenera kuyikidwa. Ndikofunikira kusungitsa glucose omwe ali m'madzi am'magazi pamlingo woyandikira kwambiri kuti achepetse vuto la fetus.

Metformin amachotseredwa mkaka wa m'mawere. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke. Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsidwa ntchito kwa mankhwalawa panthawi yoyamwa sikulimbikitsidwa. Lingaliro loletsa kuyamwitsa liyenera kuchitika poganizira zabwino za kuyamwitsa ndi chiopsezo chomwe chingakhalepo

mavuto mu mwana.

Kusungika kwa mankhwala Glucofage

Kutentha kwa 15-25 ° C. Moyo wa alumali - zaka 5 za mapiritsi a 500 mg ndi 850 mg, zaka 3 - mapiritsi a 1000 mg.

Mndandanda wa malo ogulitsa mankhwala komwe mungagule Glucophage:

Glucophage ndi Glucophage Long: phunzirani zonse zomwe mukufuna. Kumvetsetsa momwe amwe mapiritsi amtundu wa shuga wachiwiri komanso kuwonda. Amagwiritsidwanso ntchito (monga panobe mosavomerezeka) kuti achepetse ukalamba ndi kupewa matenda okhudzana ndi zaka, makamaka omwe ali ndi kunenepa kwambiri. Patsamba ili mupezapo olembedwa mchilankhulo chomveka. Phunzirani kuwonetsa, contraindication, Mlingo ndi zoyipa. Ndemanga zambiri za odwala zimaperekedwanso.

Werengani mayankho a mafunso:

Glucophage ndi Glucophage Long: Nkhani zatsatanetsatane

Mvetsetsani kusiyana pakati pa mapiritsi a Glucofage Long ndi ochiritsira. Yerekezerani ndemanga za odwala za mankhwalawa ndi anzawo aku Russia otsika mtengo.