Fluvastatin: malangizo ogwiritsira ntchito, kuchenjeza ndi kuwunika

Fluvastatin amachita ngati choletsa mpikisano HMG-CoA reductase. Zimalepheretsa Kusintha GMG-CoA mu kupitilirakomwe ndi komwe kumatsogolera zitsulo ndi cholesterol. Mothandizidwa ndi izi, cholesterol yomwe ili hepatocytessynthesis wa receptor amathandizidwa otsika kachulukidwe lipoprotein ndi kugwidwa tinthu LDL.

Monga mukudziwa, ndi kuchuluka cholesterol, mulingo griglycerides ndi apolipoprotein B, munthu amakula atherosulinosis. Malinga ndi kafukufuku wamatenda, kufa ndi kusakhazikika kwa matenda amtima, mitsempha ya magazi imatengera mwachindunji mulingo wake LDL cholesterol ndi cholesterol yathunthu. Ndi milingo yambiri ya lipoproteins yapamwamba, kufa kumachepa. Thupi silikhala ndi mphamvu pama plasma fibrinogen ndi lipoprotein a.

Chida chiribe famu. chidwi chachikulu pakupanga kwa mahomoni a steroid ndi gonads ndi grenads. Komabe, mukalandira chithandizo cha fluvastatin, odwala omwe ali ndi vuto lambiri la endocrine ayenera kusamala makamaka ndi kuwunika.

Pambuyo pakamwa makapisozi ndi mankhwala, kwathunthu ndipo mwachangu odzipereka m`mimba mundawo. Kuzindikira kwakukulu kumatheka mkati mwa mphindi 60. Pakati bioavailability ndi 24%. Thupi limakhala ndi zotsatira za "kupitilira" kudzera pachiwindi. Ndi jakisoni wa mankhwalawa, izi sizimawonedwa. Pambuyo m`kamwa makonzedwe a piritsi mawonekedwe a 80 mg, pazipita ndende mu magazi zimachitika pambuyo 3 hours. Bioavailability ndi 29%. Kudya zakudya zamafuta kumachulukitsa kuchuluka kwa zinthuzo.

Mlingo womanga wothandizirana ndi mapuloteni a plasma = 98%. Mu chiwindi, mankhwalawa amapezeka ndi makutidwe a oxidation ndipo N-dealkylation. Imafufutidwa ndi ndowe, mwanjira ya metabolites, pang'ono - yosasinthika. Hafu ya moyo pambuyo kumwa mapiritsi ndi pafupifupi maola 9. Odwala omwe ali ndi matenda a chiwindi, fluvastatin amatha kudziunjikira, komanso kuchuluka kwa plasma kwa mankhwala ndi kuchuluka kwa AUC.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amalimbikitsidwa kuti agwiritsidwe ntchito ndi odwala akuluakulu:

• ndi kuchuluka kwazonse cholesterol, triglycerides, otsika kachulukidwe lipoprotein cholesterol, apolipoprotein Bpa pulayimale hypercholesterolemia ndi Hyperlipidemia,
• ndi matenda a mtima kuti muchepetse kupita patsogolo atherosulinosis,
• monga prophylactic ndi Matenda a mtima wa Ischemicpambuyo angioplasty.

Fluvastatin imalembedwa kwa ana ndi achinyamata ngati gawo la mankhwala ovuta pamlingo wokwezeka cholesterol, apolipoprotein B ndi LDL cholesterolndi banja lochizira hypercholesterolemia.

Contraindication

Thupi limaphatikizidwa kuti ligwiritsidwe ntchito:

• at mankhwala osokoneza bongo,
• odwala matenda a chiwindi,
• ndi kuchuluka kwa chiwindi michere osadziwika,
• nthawi mimba,
• mwa ana ochepera zaka 10,
• mukamayamwa.

Zotsatira zoyipa

Zotsatira zotsatirazi zimatha kuchitika pakumwa mankhwala a fluvastatin:

Zosawonekera kwambiri: rhabdomyolysis, chiwindi, myositis, gynecomastiazosokoneza chithokomiro ndi gwero la adrenal.

Bongo

Popereka mankhwalawa mu gawo limodzi la 80 mg, machitidwe osiyanasiyana osiyanako sanawonedwe. Ngati odwala adalandira mankhwala omwe amapezeka ndi mapiritsi a nthawi yayitali 640 mg kwa masiku 14, zotsatira zoyipa kuchokera m'matumbo zimachitika, kuchuluka kwa plasma, ALT, ndi AST kumawonjezeka.

Mankhwala othandizira, dialysis osagwira ntchito.

Kuchita

Isoenzymes amatenga nawo kagayidwe kamankhwala. cytochrome P450, CYP2C9, CYP2C9, CYP3A4. Ngati imodzi mwanjira za kagayidwe ndi kuperewera kwa mankhwalawa ndizosatheka, kuchepa kwake kungalipiridwe ndi wina.

Sitikulimbikitsidwa kuphatikiza mankhwalawo ndi zoletsaHMG-CoA reductase.

Magawo okhala ndi ma inhibitors CYP3A4, erythromycin, cyclosporin, intraconazole zimakhudzanso magawo a mankhwala a pharmacokinetic. Akaphatikizidwa ndi phenytoin kuchuluka kwa plasma kwa onse a mankhwalawa.

Analimbikitsa kuti atenge colestyramine Maola 4 pambuyo pa fluvastatin kuti muwonjezere zowonjezera zamankhwala.

Ndi kuphatikiza kwa mankhwala phenytoin Chenjezo limalangizidwa; Kuphatikiza uku kumabweretsa kuwonjezeka kwa milingo ya plasma ya fluvastatin ndi phenytoin.

Munthawi yomweyo makonzedwe a chinthu ndi diclofenac amachititsa kuchuluka kwa plasma ndende komanso Auc chomaliza.

Mankhwalawa akhoza kuphatikizidwa tolbutamide, losartan.

Odwala matenda ashugaomwe amatenga fluvastatin ndi glibenclamide, ayenera kusamala kwambiri, akuyang'aniridwa ndi dokotala, makamaka ndi kuwonjezeka kwa mlingo wa tsiku ndi tsiku wa fluvastatin mpaka 80 mg patsiku.

Mukaphatikiza mankhwala ndi mathitidine, cimetidine ndi omeprazole pali kuwonjezeka kwakukulu kwa kuchuluka kwa plasma ndende ndi AUC ya thupilo, pomwe chilolezo cha plasma cha Fluvastatin chachepetsedwa.

Mankhwalawa odwala omwe akhala akutenga nthawi yayitali rifampicinkukula kwakukulu Auc ndi Cmax.

Mosamala, phatikizani mankhwala awa ndi anticoagulants a warfarin mndandanda. Ndikulimbikitsidwa kuwunika nthawi ndi nthawi prothrombin, ngati kuli kotheka, musinthe.

Malangizo apadera

Asanayambe chithandizo, ndikofunikira kukhazikitsa molondola mbiri ya lipid ya wodwalayo, yonse cholesterol, triglycerides ndi HDL cholesterol. Osachotsa milandu yachiwiri Hyperlipidemia, matenda ashuga, hypothyroidism, dysproteinemia, nephrotic syndromematenda a chiwindi uchidakwa.

Pakatha mwezi umodzi, tikulimbikitsidwa nthawi ndi nthawi kudziwa mulingo wa lipids ndikusintha Mlingo, kutengera magawo a labotale.

Akaphatikizidwa ndi fluvastatin ndi cholestyramine ndi mankhwala ena ofanana, tikulimbikitsidwa kumwa usiku.

Zokonzekera zomwe zili ndi (Analogs)

Zina lamalonda zamankhwala: Leskol, Leskol Forte.

Ndemanga za mankhwalawa ndizosiyana. Kwa ena, mankhwalawa amabwera, amawona njira zabwino zochiritsira, kwa ena, mankhwalawo sanathandize konse.

• “... Ndinamwa mankhwalawa kuphatikiza mankhwala ena, ndikutsatira kudya. Zotsatira zake zinali zabwino. Koma atangochotsa, zonse zidabwezedwa”,
• “... Mankhwala okayikitsa ngati ine. Zikuwoneka kuti ndalama zokha ndizopopera kuchokera kwa odwala, ogwira ntchito pang'ono. Ndikwabwino kumwa atorvastatin”,
• “... Atandiwuza mapiritsiwo kwa ine, anandiuza nthawi yomweyo kuti ndiyenera kusintha moyo wanga ndikutsatira kadyedwe, apo ayi sizingakhale zomveka. Anayamba kulandira chithandizo, mayesowo akuwoneka kuti ali bwino. Palibe zoyipa zomwe zidachitika, ndikumva bwino”.

Mtengo wa Fluvastatin, kuti mugule

Mtengo wa mapiritsi 28 a mankhwalawa Leskol, ndi mlingo wa 80 mg aliyense uli pafupifupi ruble 2800.

Maphunziro: Anamaliza maphunziro awo ku Rivne State Basic Medical College ndi digiri ku Pharmacy. Anamaliza maphunziro ake ku Vinnitsa State Medical University. M.I. Pirogov ndi gulu lozindikira kutengera izi.

Zokumana nazo: Kuyambira 2003 mpaka 2013, amagwira ntchito monga mfesi ya zamankhwala komanso manijala wa khemisi. Anapatsidwa makalata komanso kusiyanasiyana kwa zaka zambiri akugwira ntchito molimbika. Zolemba pamitu yachipatala zidasindikizidwa m'mabuku azofalitsa (manyuzipepala) komanso pazamasamba osiyanasiyana pa intaneti.

Mawonekedwe ndi kipimo

• Fluvastatin sodium.
• Magnesium wakuba.
• Sodium bicarbonate.
• MCC.
• Talc.
• Wowuma chimanga.
• Calcium calcium.
• Titanium dioxide.
• Iron oxide.
• Gelatin
• Shellac.
• Zakudya zojambula.
• Opadry (osakaniza pakugwiritsa ntchito utoto wamafuta).

Mlingo wa fluvastatin ndi mapiritsi okhala ndi mchere wa fluvastatin sodium, kapena mawonekedwe a kapisozi amasulidwe. Makapisozi amakhala ndi gyroscopic ufa wabwino. Mapiritsi ake ndi achikasu kapena oyera. Mankhwalawa amasungunuka bwino m'madzi, ethanol, methanol. Ili ndi mankhwala monga hypocholesterolemic effect (m'magazi, fluvastatin imatsitsa cholesterol). Dzina Lachilatini mu Chinsinsi litha kulembedwa kuti Fluvastatin (mtundu wa Fluvastatini). Cholinga cha pakamwa.

Fluvastatin, malinga ndi malangizo, amamuwonjezera chiwindi mpaka 90%, kudzera mu genitourinary system mpaka 10%. Chifukwa chake, njira yodzikundikira mthupi ndiyochepa ngakhale yogwiritsa ntchito nthawi yayitali. Fluvastatin ndi mankhwala ochokera ku gulu la reductase inhibitors. Chithandizo chogwira mankhwalawa chimagwira ngati choletsa (chimachepetsa) mafuta m'thupi la munthu.

Mankhwalawa amasankhidwa ndi dokotala yemwe amaganizira za wodwala ndi malangizo. Analogues ochokera ku gulu la ma statins amatha kulembedwa, mwachitsanzo, pansi pa dzina la malonda lovastatin, atorvastatin. Ndi zoletsedwa kuti musankhe nokha mankhwala.

Zotsatira zoyipa

Nthawi zambiri imalekeredwa, koma zoyipa zoterezi ndizotheka poika fluvastatin (zomwe zikuwonetsedwa mu malangizo):

• Kukhumudwa kwam'mimba (nseru, kupweteka kwam'mimba, kapamba, kudzimbidwa, kukhumudwa, kudzimbidwa).
• Vuto la kugona.
• Mutu.
• Kutopa, kukhumudwa.
• Kusokonekera mu kayendedwe ka magazi ndi dongosolo la mitsempha.
• Ziwengo (zotupa pakhungu, urticaria. Nthawi zambiri - anaphylactic reaction.)
• Kuphwanya chombo.
• Kulephera mu chiwindi.
• Kutupa. (Nthawi zambiri - nkhope, kawirikawiri - edema ya Quincke).
• Kufooka minofu, nyamakazi.
• Kuphwanya maliseche (erectile dysfunction, kuchepa kwa chilakolako chogonana).
• Mavuto pantchito ya tinthu tating'onoting'ono.
• Zovuta za chithokomiro England komanso tiziwongola timene timatulutsa.
• Maonekedwe a mavuto mu kupuma (bronchitis, sinusitis).
• Maonekedwe a zovuta mu genitourinary system (kwamikodzo thirakiti matenda).

Zizindikiro zonse pamwambazi zimatha kuchitika ndi mankhwala osokoneza bongo. Pankhaniyi, thandizo ndi chizindikiro. Matenda onse ayenera kuuzidwa kwa dokotala.

Fluvastatin adaperekedwa kwa odzipereka athanzi kuti adziwe zoyipa. Pa mlingo umodzi wapamwamba wa 80 mg mu mawonekedwe a makapisozi, palibe zotsatira zovulaza zomwe zapezeka. Pamene fluvastatin idagwiritsidwa ntchito munthawi yayitali (yayitali), zotsatirapo zoyipa zimapezeka.

Malangizo ogwiritsira ntchito

Fluvastatin malinga ndi malangizo amaperekedwa kwa akulu ndi ana azaka zopitilira 10. Koma atsikana amalimbikitsidwa kutenga atatha msambo, popeza sipanapezeke kafukufuku wazomwe zimachitika chifukwa cha mankhwalawa pama mahomoni azakugonana achikazi.

Dongosolo la chithandizo lidzapangidwa ndi dokotala wopezekapo, kutengera malangizo. Nthawi zambiri, odwala amapatsidwa 20 mg mpaka 40 mg kamodzi patsiku, popeza cholesterol synthesis imagwira usiku. Fluvastatin sayima pawokha pakudya. Asanayambe chithandizo, wodwalayo amasamutsira ku zakudya zapadera kuti muchepetse cholesterol.

Kuchuluka kwake kumatheka mkati mwa masiku 24 kuyambira pachiyambireni mankhwala. Munthawi yonse ya chithandizo, HDL peresenti (kuchuluka kachulukidwe lipoproteins) m'magazi amayenera kuyang'aniridwa kuti asinthe Mlingo. Kuchita kwa fluvastatin kumapitirira kwa nthawi yayitali ndikugwiritsa ntchito nthawi yayitali.

Mlingo molingana ndi malangizo, kuchepetsa LDL mpaka 25%: kapisozi 1 (40 mg) kapena piritsi 1 (80 mg) patsiku. Kapena makapisozi awiri kawiri patsiku, malinga ndi malangizo ndi malangizo a dokotala. Mlingo woyamba wa ana ndi 20 mg. Ngati mavuto akuchitika, ndiye kuti muyenera kuuza dokotala nthawi yomweyo za iwo. Ndikulimbikitsidwa kusokoneza chithandizo ndi fluvastatin ndikumakhalabe ndizotsatira zoyipa kwa sabata limodzi. Pankhaniyi, yopuma ya masabata awiri imapangidwa ndipo nthawi iyi ikatha, fanizo la ma statin ena limaperekedwa kwa wodwala (mwachitsanzo, lovastatin).

Gwiritsani ntchito pa nthawi yoyembekezera

Fluvastatin, malinga ndi malangizo, amaletsedwa panthawi yapakati. Kafukufuku wokhudzana ndikugwiritsa ntchito 40 mg wa sodium fluvastatin pazochita zamtunduwu wa azimayi sanachitike. Zoletsa za kuchepetsa thupi zimachepetsa kapangidwe ka cholesterol ndipo, mwina, zimachepetsa kaphatikizidwe kazinthu zina zomwe zimapanga zinthu zofunikira kwa mwana wosabadwayo kuchokera ku cholesterol, zimatha kuyambitsa kuphwanya chitukuko cha mwana wakhanda akapatsidwa udindo.

Amayi amapatsidwa mankhwala a fluvastatin pokhapokha ngati mwayi woti akhale ndi pakati ndi wochepa. Mimba ikachitika munthawi ya mankhwala, ndiye kuti mankhwalawo amayenera kuyimitsidwa nthawi yomweyo ndikuwuza dokotala za izi kuti musinthe chithandizo china. Pa nthawi yoyamwa, imaletsedwanso, chifukwa imalowa mkaka wa mayi ndi madzi a m'magazi.

Kufikira zaka 9, fluvastatin imatsutsana. Kwa ana okulirapo, muyezo wake malinga ndi malangizo, malinga ndi madokotala. Fluvastatin imalembedwa kwa ana (atsikana atayamba msambo) ndi achinyamata ngati gawo limodzi la chithandizo chokwanira cha cholesterol chokwanira, apoliprotein B ndi LDL cholesterol, ndi heterozygous Famer hypercholesterolemia kuphatikiza mankhwala. Palibe malipoti a zidziwitso zakuchipatala pakugwiritsa ntchito ana osaposa zaka 9.

Ma Analogs a fluvastatin

Zofanizira za Fluvastatin ndi Leskol ndi Leskol Forte. Amachitanso chimodzimodzi. Mbadwo watsopano wama statins ukuphatikizapo Simvastatin kapena Atorvastatin. Amakhala ndi tanthauzo lalitali, koma aliyense ali ndi machitidwe amodzi payekha, ndipo kuvomereza kwawo kuyenera kukhala mosamalitsa malinga ndi malangizo, atasankhidwa ndi dokotala.

Kugwiritsa Ntchito

Ndemanga za mankhwalawa ndizosiyana kwambiri, wina adabwera ndimankhwala, wina adasintha.

Wodwala Plato zaka 35: "Mankhwalawo adandiuza kuti ndiwonetsetse kuti ndakweza cholesterol komanso chizindikiro cha triglycerides. Anandisinthanso ndikudya zakudya zopatsa thanzi. M'milungu itatu yoyambirira, zotsatira zake zinali zochepa kwambiri, koma pofika sabata lachinayi, zizindikirazo zinayenda bwino kwambiri, kuchuluka kwa lipids ndi triglycerides kunachepa. Ine, nditakondwera ndi izi, ndidasiya kuyang'anira momwe ndimadyera, koma Fluvastatin adamwanso. Kwa miyezi ingapo ndinapeza mapaundi owonjezera, koma mayesowo anali abwino. Adokotala atazindikira kuti ndasiya kudya zakudya zamagulu, adandidzudzula. Pambuyo pake, ndinayamba kutsatira mosamalitsa zomwe zalembedwa m'malangizo, malingaliro onse a dotolo komanso wamankhwala othandizira odwala. Zidalandilidwa, monga chotengera, sindimamwa Fluvastatin kwa chaka chimodzi tsopano, koma ndikupitilizabe kutsatira kadyedwe koyenera ndi masewera olimbitsa thupi (panali malingaliro a dokotala). Mayeso onse amakhala abwinobwino. ”

Wodwala Tatyana wazaka 40: “Choyamba ndidatenga atorvastatin monga momwe adalembera malangizo. Zinali ndi zovuta zoyipa, ndipo adotolo adasinthanitsa ndi fluvastatin, kufotokoza kuti ndi yotetezeka komanso yolekeredwa bwino. Nthawi yomweyo kumwa fenofibrate kusintha zotsatira. Panopa ndimalandilirabe chithandizo, mayeso anga akupita patsogolo. Mofananamo, ndinayamba kudya moyenerera, poganizira malingaliro a katswiri wazakudya ndikuchita masewera olimbitsa thupi. Amakhala bwino. Zotsatira zoyipa sizimandivutitsanso. ”

Dokotala ndi wa endocrinologist. Tolstolobov Vadim Petrovich zaka 50: "Poyamba adapereka atorvastatin kwa odwala ake ngati mankhwala amakono omwe ali ndi mphamvu yayitali. Koma odwala ena adanena zotsatira zoyipa za mankhwalawo. Pambuyo pakutha kwake, ndikupuma kovomerezeka, Fluvastatin adalamula.Palibe zotsatira zoyipa zomwe ndimachita odwala. Kuphatikiza zowonjezera, ndimapereka ndi fenofibrate. "

Chithandizo cha mankhwala osokoneza bongo ndi fluvastatin ndi mankhwala adokotala, malinga ndi malangizo, pambuyo povomerezeka pamankhwala othandizira pakudya ndi masewera olimbitsa thupi. Kutenga Fluvastatin sikulinso kukana zakudya zoyenera, mavitamini ndi masewera olimbitsa thupi. Ndizothandiza kwambiri ngati wodwala azikhala ndi moyo wathanzi.

Zisonyezo poika fluvastatin

Fluvastatin wothandizira, dokotala wothandizira, amamulembera ngati amachiza matenda ndi kusokonezeka m'thupi la wodwala:

• Mtundu woyamba wa nthendayi ndi nambala yapamwamba ya lipid mu hypercholesterolemia yamagazi,
• Atherogenic mtundu wa matenda a dyslipidemia a mtundu woyamba ndi wachiwiri wa chitukuko,
• Ndi matenda a zimitsempha zamagazi, atherosulinosis mu mawonekedwe ake onse. Mukamamwa Fluvastatin, ndikofunikira kuti wodwala atenge mavitamini osiyanasiyana, komanso kufufuza zinthu ndi mchere,
• Ndi matenda a endocrine ziwalo, lembani matenda a shuga 2.

Mwa njira zopewera, fluvastatin inhibitor adayikidwa kuti apewe izi:

• Pofuna kupewa kuthamanga kwa kuthamanga kwa magazi kwa odwala omwe ali ndi matenda oopsa,
• Pofuna kupewa kulowerera m'mitsempha, komanso chithokomiro cham'mimba,
• Pofuna kupewa matenda a mtima ndi kayendedwe ka magazi,
• Poletsa kukula kwa matenda a shuga, matenda a shuga, okhala ndi vuto la metabolic lomwe limayamba chifukwa cha kunenepa kwambiri.

Hypercholesterolemia

Mlingo ndi makonzedwe

Malinga ndi malangizo ogwiritsira ntchito, mankhwalawa a group la statin Fluvastatin amatha kutumizidwa pamagulu onse a anthu azaka zopitilira 10. Kuti mugule mankhwalawa, muyenera kulandira mankhwala kuchokera kwa dokotala.

Zomwe zimayenera kumwa mankhwalawa ndikuti musanamwe mankhwalawa Fluvastatin, ndikofunikira kuti wodwalayo adye chakudya cha anticholesterol, chomwe chidzayamba kutsitsa kalozera wa lipoprotein m'thupi.

Zakudya zoterezi zimawonedwanso panthawi yamankhwala omwe amapezeka ndi Fluvastatin, ndipo ngati pakufunika kuthandizidwa, amatha kuwonjezeredwa ngakhale kutha kwa mankhwala.

Mapiritsi a Fluvastatin amatengedwa pakamwa, ngakhale wodwala amadya panthawiyi kapena sanadye chakudya. Chodabwitsa kutenga ma statins ndikuti amalimbikitsidwa kutengedwa nthawi yomweyo.

Kodi dzina la mankhwala fluvastatin

Malangizo omwe angatenge cholevolatin cholesterol index ndi awa:

• Kuti muchepetse cholesterol yotsika kwambiri ndi 25.0%, ndikofunikira kutenga piritsi 1 limodzi ndi kuchuluka kwa mamiligalamu 40.0, kapena ma milligram 80.0 kamodzi patsiku makamaka madzulo.
• Kuti mupitilize kutsitsa cholesterol index ndikutsitsa kuposa 25.0%, ndiye kuti akuyenera kutenga piritsi ya 20,0 mamililita 1 patsiku kwa nthawi yoyamba, ndikuwonjezera kuchuluka kwa miligir 8080 tsiku lililonse.

Kuchuluka kwa ma statins m'thupi kumachitika patatha masiku 30 atachita mankhwala. Fluvastatin sizinali zosiyana ndipo amasonyezanso chithandizo chokwanira kwambiri pakuchepa kwa index ya lipoprotein patatha mwezi umodzi.

Kuphatikiza mphamvu yochepetsera lipids, njira yotalikira yayitali imafunikira kuti muchepetse kuchuluka kwa mamolekyulu a cholesterol m'magazi.

Mlingo woyamba wa tsiku lililonse kuyambira ubwana zaka 10 ndi mamilimita 20.0.

Mankhwalawa amathandizidwa kunja kwa thupi mothandizidwa ndi maselo a chiwindi ndi bile.

Chifukwa chake, odwala omwe ali ndi matenda a impso, palibe chifukwa chosinthira kwapadera kwa mankhwala a fluvastatin.

Zotsatira za pharmacological

Ikulowa m'matumbo am'mimba, piritsi kapena chipewa cha kapisozi chimasungunuka pang'onopang'ono ndikutulutsa ndikutsatira pang'onopang'ono kwa zinthu zomwe zimagwiritsidwa ntchito ndi makoma am'mimba. Kuchokera mucous membrane wam'mimba, fluvastatin imalowa m'magazi, pomwe amapanga mgwirizano wophatikizana ndi mapuloteni a plasma (kuchuluka kwa kumangirira kumatha 90%), omwe amatsitsidwa thupi lonse. Fluvastatin imagwira ntchito kwambiri ikalowa m'chiwindi cha munthu: biosynthesis of low density lipoproteins (LDL) ndi ochepa osachulukitsa lipoproteins (VLDL) imaletseka. Kuchepa kwa mulingo wa LDL ndi LDL kumathandizira kukulitsa chidwi cha zolandila ku mitundu iyi ya lipoproteins ndipo, chifukwa chake, zomwe amapeza ndi hepatocytes ndi metabolism yotsatirayi imakhala bwino.

Kuphatikiza apo, zinthu zomwe zili pamapiritsiwa zimagwira ngati choletsa apoliprotein B ndi TG, omwe amagwira ntchito ngati chintchito chonyamula mafuta a "cholesterol" oyipa. Poyerekeza ndi kuchepa kwa LDL ndi VLDL, kuwonjezeka kwa milomo ya lipoproteins yapamwamba kwambiri (HDL) kumadziwika. Zidadziwika: kutsika kwa HDL kwa nthawi yoyambira njira zamankhwala othandizira, kukwera kwakukulu kwa HDL pakati pa maphunziro. Makhalidwe oyenerana ndi nkhaniyi: odwala omwe ali ndi HDL yochepa pakati pamaphunzirowa panali kuwonjezeka kwa "cholesterol yothandiza" ndi 7%, ndipo mwa odwala omwe ali ndi mulingo wabwinobwino wa HDL - ndi 14%. Zotsatira zamachitidwe omwe ali pamwambapa ndi kuchepa kwaponseponse mu LDL, VLDL, apoliproteins B ndi TG pama plasma amunthu.

Pazitali kwambiri yogwira ntchito yogwira thupi imawonedwa ola limodzi mutatha kumwa mankhwalawa. Kudya sikumakhudza mayamwidwe omaliza a mankhwalawa, koma kumachepetsa kuyamwa. Komabe, zakudya zamafuta kwambiri zomwe zimadyedwa musanamwe mapiritsi kapena kapisozi zimatha kupweteka m'matumbo a zinthu zomwe zimagwira m'magazi a magazi. Kutha kwa theka-moyo kumakhala mpaka maola 9 kutengera mlingo umodzi.

Achire zochizira zotsatira zimawonedwa pakatha masabata awiri chiyambireni mankhwalawa. Kwambiri achire zotsatira zimawonedwa pambuyo milungu inayi kuchokera woyamba kumwa.

Amapukusidwa mu chiwindi ndikuwachotsa panthawi yopanga (kupitirira 90%) komanso kudzera mu kwamikodzo dongosolo (mpaka 10%). Zotsatira (zowonjezera) ndizochepa kapena sizipezeka konse. Kuyerekeza kokhala ndi thanzi labwino kumachitika ndi njira ya mankhwala yopitilira chaka chimodzi.

Mlingo ndi makonzedwe

Mosasamala nthawi yakudya, fluvastatin amagwiritsidwa ntchito kamodzi patsiku muyezo wa 80 mg kapena kamodzi kapena kawiri pa tsiku Mlingo wa 20 kapena 40 mg. Nthawi yakumwa mankhwalawa siyikhudzana ndi mayamwidwe, koma akatswiri ambiri othandizira amalimbikitsa maola a m'mawa atangodzuka. Pogwiritsa ntchito kufatsa kwa fluvastatin poyerekeza ndi mankhwala osokoneza bongo am'badwo wotsatira wama statins, mu milandu yambiri kumakhala kofunikira kugwiritsa ntchito mankhwalawa kamodzi muyezo wa 80 mg. Kuchepetsa Mlingo kumachitika pokhapokha ngati kuchuluka kwa ma lipids kupitilira muyeso wochepera 15% ndipo sikufuna kutsika kwa plasma. Pankhaniyi, yambani ndi kuchuluka kwa 40 mg patsiku, logawidwa pawiri: 20 mg m'mawa ndi madzulo.

Munthawi yamankhwala omwe mumalandira ndi fluvastatin, tikulimbikitsidwa kuti muzilamulira zomwe zili zam'magazi m'magazi amwazi kuti musinthe ngati kuli koyenera. Kuwunikira kumachitika kamodzi m'miyezi isanu ndi umodzi, ngati palibe njira zofunira maphunziro ochulukirapo. Njira zoyambirira ndizodandaula za wodwala za momwe alili.

Zochita zochepa zothandizira: miyezi 12. Mukamamwa mankhwala kwa miyezi 30 Mlingo wa tsiku ndi tsiku wa 80 mg wochokera pa maphunziro, kupitilira kwa coronary atherosulinosis kumachepa kwambiri. Chifukwa chake, kutalika kwa njira ya achire kwamiyezi 36 kwatha. M'tsogolomu, ndikofunikira kumwa mankhwalawa kwa miyezi 12 ngati prophylactic. Njira yochepetsera yochepera: milungu inayi.

Zotsatira zoyipa ndi bongo

Kufunika kwakusokonezeka kwa chithandizo chamankhwala chifukwa cha zovuta sizipitilira 1%. Mankhwala amalekeredwa bwino. Nthawi zina, zitha kuzindikirika: Zizindikiro za bronchitis, mutu, chizungulire, nseru, zizindikiro za kukomoka. Kuchotsa mankhwalawa kumalimbikitsidwa ndikusunga izi kwa sabata lopitilira. Pakukakamizidwa kuchoka, muyenera kutenga kupumula kwapakati pa milungu iwiri kenako ndikulemberani kufanana kwa gulu la ma statins: lovastatin, atorvastatin kapena mankhwala ena.

Zochitika zowopsa m'moyo wamunthu komanso thanzi mukamamwa mankhwala ambiri sizinachitike. Kusagwirizana m'matumbo am'mimba komanso zizindikiro za dyspeptic zitha kudziwika. M'magazi am'magazi, ma transaminase okwanira amatha kuyang'aniridwa, omwe amachepetsa ndi kuchepa kwa mulingo kapena kukana kumwa mankhwalawa.

Zofunikira

• Fluvastatin pakadali pano ndi reductase inhibitor, kuphatikiza komwe kumaloledwa ndi mankhwala a gulu la fibrate. Izi zimachitika chifukwa cha kufatsa kwamphamvu kwa chinthu ichi pathupi.
• Fluvastatin idakumana ndi mayesero ambiri a labotale ndi zamankhwala, chifukwa chakuchita kwake kwatsimikiziridwa.
• Mtengo wa "Fluvastatin", monga lamulo, ndiwotsika poyerekeza ndi mankhwala am'badwo waposachedwa.

Ndemanga za "fluvastatin"

Alexander, wazaka 37

Dokotala wotsatira wakubwera kwa ine wotchulidwa fluvastatin pamene kuchuluka kwa mafuta a triglycerides ndi cholesterol kumapitilira muyeso. Zakudya za hyperlipidemic zinalimbikitsidwa pamodzi. Masabata atatu oyamba sindikuwona zotsatira zazikulu. Pamapeto pa sabata la 4, patatsala masiku awiri kuti adziwe matendawa, adazindikira kusintha kwamphamvu kwa thupi - adalumikiza izi ndi malangizo omwe adalandira. Adazindikira kuchepa kwa ndende ya lipid ndi 11%, ndi triglycerides - zikuwoneka, ndi 8% (sindikukumbukira ndendende tsopano). Zotsatira zake, ndidasankha kuchita zoyesayesa zanga popanda kudziwitsa adokotala. Kutaya chakudyacho - sikunandilimbikitse kuchita zabwino zambiri. Kwa miyezi iwiri sindinatsatire zofuna za chakudya, koma malinga ndi malangizo omwe ndagwiritsa ntchito makapisozi a Fluvastatin. Ndidapeza ma kilogalamu atatu osadziwika bwino. Kumapeto kwa mwezi wachitatu kuyambira pa chiyambi cha maphunziro, adamupezanso - kusintha kwina kunadziwika (kuchuluka kwa lipids ndi triglycerides kutsika ndi peresenti zingapo). Chifukwa chake, ndikuganiza kuti mankhwalawa ndi othandizadi. Koma kuphatikiza ndi chakudya, ndikofunikira, popeza mapaundi owonjezera - ku china chilichonse. Ndakhala ndikumwa Fluvastatin pafupifupi chaka tsopano. Ndidapereka mankhwala okwanira asanu.

Nikita Stolbovsky, wazaka 52, endocrinologist, wathanzi

Moni Choyamba, kuwunika kwanga kwa Fluvastatin kudzakhala kothandiza kwa akatswiri, koma ngati zingakhale zothandiza ndizokondwa. Ndi za machitidwe anga. Kukhazikitsidwa koyamba kwa atorvastatin, monga mankhwala oyenera kwambiri kuti muchepetse kutsata kwa LDL, kunayambitsa zotsatira zoyipa mwa wodwala yemwe akuganiza kuti akukula kwa myositis. Ndinafika pochita njira yofulumira yochotsetsa komanso kukonza zadzidzidzi. Patatha mwezi umodzi, chithandizo chinkayenera kupitilizidwa, popeza ndende ya LDL inakulanso. Atorvastatin adalowedwa m'malo ndi lovastatin, monga mankhwala otetezeka kwambiri mchitidwewu. Zotsatira zake ndizosakwanira achire. Adayamba kufunafuna njira zothanirana ndi zovuta zowerengera. Anayimitsa chidwi cha "Fluvastatin" ndikuwonjezereka kwa achire zotsatira za "Fenofibrate". Fluvastatin adaikidwa 20 mg kawiri tsiku lililonse. Patatha mwezi umodzi, kuchepa kwa ndende ya LDL kunadziwika. Koma, ndikutumiza, ndimatumiza wodwala mwezi uliwonse kuti akalandire mayeso.

Fluvastatin pa nthawi yapakati

Ndi zoletsedwa kupereka mankhwala Fluvastatin pa nthawi ya mwana wosabadwa ndi mwana. Malinga ndi kafukufuku wasayansiyu, zinadziwika kuti kutenga ma statin kumakhudza kwambiri khanda lakhanda losabadwa ndipo kumayambitsa matenda abwinobwino omwe amakhala obadwa mwachilengedwe.

Ngati inhibitor yamtunduwu ikulepheretsa kapangidwe ka cholesterol m'thupi la mayi wapakati, ndiye kuti maselo onse a mwana woyandama akuyatsidwa kuperewera kwa cholesterol. Kuperewera kwa zinthu zomanga (cholesterol) m'maselo kumabweretsa zoopsa pobadwa.

Amayi omwe ali ndi mwayi wobala mwana malinga ndi zaka amapatsidwa mankhwala a fluvastatin, omwe ali ndi vuto limodzi lokha, kugwiritsa ntchito njira zakulera panthawi yamankhwala omwe amapezeka ndi ma statins.

Ngati mayi ali ndi pakati, ndikofunikira kusiya kumwa mankhwalawo, kapena, ngati kuli kotheka kukana kumwa mapilitsi, pali funso lothetsa mimbayo.

Panthawi yomwe mayi akuyamwitsa mwana, fluvastatin sayeneranso kutumikiridwa.

Ma Statin amatha kulowa mkaka wa m'mawere, ali ndi chidwi kwambiri poyerekeza ndi madzi am'magazi.

Hypersensitivity Syndrome ndi Fluvastatin

Kuwonetsedwa kwa hypersensitivity syndrome mwa odwala akuwonetsedwa muzotsatira ndi ma pathologies otsatirawa:

• Kukula kwa anaphylactic,
• Quincke kutupa,
• Lupus Syndrome.

Njira yogaya chakudya imayankha pakulowa kwa ma statins m'thupi lanu:

• Kutupa kwa maselo a chiwindi hepatitis amitundu yosiyanasiyana,
• Cell kufa necrosis,
• Kusanza pafupipafupi kuchokera mthupi,
• Njira yotupa m'maselo a kapamba wa kapamba,
• Jaundice wa cholecystitis etiology,
• Chakudya chokwanira kugaya chakudya anorexia,
• Hepatoma matenda,
• Hepatic organ cirrhosis.

Hepatic organ cirrhosis

Momwe khungu limathandizira pakubala komanso njira zolerera

Khungu ndi limodzi mwa oyamba kuyankha pazotsatira zoyipa za mankhwala a fluvastatin.

Kuwonekera pakhungu kumawatsogolera kufikira dziko lino:

• Alopecia m'malo ena a khungu,
• Khungu limawoneka pakhungu,
• Khungu louma limayamba,
• Zilime zowuma zimapezeka,
• Pathology imayamba pruritus.

Zotsatira zoyipa za thupi pakutenga ma statins zimadziwikanso komwe kumachokera.

Ndipo izi zimawonekera mu kuphwanya maliseche:

• Libido yachepetsedwa kwambiri m'thupi la akazi,
• Pali zisonyezo zakutha kwa amuna,
• Gynecomastia matenda,
• Mavuto obwera chifukwa cha ntchito
• Kukakamiza kwa umuna kumachitika.

Kuphatikiza pa chisonyezero chosavomerezeka ichi cha zomwe thupi limachita potenga ma statins pathupi, ma cell a cyular ndi kusokonezeka kwa mandala.

Mukamamwa Fluvastatin, palinso kuwonjezeka kwa ntchito ya dongosolo lonse la endocrine ndi gland ya chithokomiro.

Pomaliza

Mankhwala Fluvastatin ndi mankhwala otetezeka kwambiri kwa ziwalo zonse zathupi, omwe amachepetsa mokoma kuchuluka kwa lipoprotein m'magazi, ndipo kugwiritsidwa ntchito kwake ndi mankhwala a fibrate kumathandizira kuchiritsa kwachidziwitso popanda kuyambitsa zovuta zambiri.

Komanso, mankhwalawa ali ndi zochepa zotsutsana kuti agwiritse ntchito.

Ndemanga za Odwala

Sergey, wazaka 49, mzinda wa Peter: Ndidapangidwa ndi dokotala-endocrinologist wa mankhwala a Fluvastatin, atazindikira kuti anali ndi LDL yayikulu. Kuphatikiza pa kumwa mankhwalawa, zakudya za anticholesterol zimayikidwa. Pambuyo pa masiku 21, ndinadutsa mayeso otsimikizira ndipo ndinawona kutsika kwa 10,0% m'm lipids. Sindinatsatire kudya kwamphamvu, chifukwa kudya koteroko kunandipangitsa kuti ndikhale ndi njala komanso wokwiya nthawi zonse.Popanda kutsatira kwambiri zakudya, fluvastatin adawonetsa zochizira zake. LDL yomwe idachepa.

Eugenia, wazaka 56, mzinda wa Saratov: Ndisanatenge Fluvastatin, ndinatsitsa cholesterol ndi chakudya komanso Atorvastatin. Zotsatira zoyipa za mankhwalawa zimakhudzanso chimbudzi komanso mphamvu yamanjenje. Kwa ine, adotolo adasinthanitsa mankhwalawo ndi fluvastatin ndipo, kuti apititse patsogolo, adapereka makulidwe amodzi munthawi yomweyo. Ndakhala ndikugwiritsa ntchito mankhwalawa kwa masiku 20, kufikira nditamva zovuta, ndipo mayeso azakuwonetsa adachepa.

Kupanga ndi mawonekedwe a kumasulidwa

Chosakaniza chophatikizacho ndi sodium fluvastatin. Kuphatikiza apo, zitha kugwiritsidwa ntchito:

• magnesium wakuba,
• sodium bicarbonate,
• talcum ufa
• wowuma chimanga
• gelatin ndi zinthu zina.

Mankhwala amaperekedwa mu mawonekedwe a mapiritsi achikasu kapena oyera ndi makapisozi. Zotsirizazo zimakhala ndi ufa wabwino wa hygroscopic. Chochita chimasungunuka kwambiri muzakumwa. Ntchito pakamwa.

Pharmacology

Pambuyo polowetsa lumen ya m'mimba (m'mimba), kuwonongeka kwapang'onopang'ono kumachitika, ndikutsatira ndikuchotsa ntchito yogwira ntchito. Amamezedwa ndi makhoma a matumbo, kulowa m'magazi ambiri. Pazipita ndende ya fluvastatin zimawonedwa mphindi 60 mutatha kumwa mankhwala. Chakudya sichimakhudza mayamwidwe, koma chimathandiza kuyamwa pang'onopang'ono. Hafu ya moyo wa mankhwalawa ndi maola 9.

Kuthandiza kwenikweni kwamankhwala kumatheka pakatha masabata awiri atayamba maphunziro. Zotsatira zazikulu zimawonedwa pambuyo pa masabata 4 ogwiritsa ntchito pafupipafupi. Amawachotsa pamodzi ndi ndowe (pafupifupi 90%) ndi mkodzo (10%). Zowonjezera (zowonjezera) ndizochepa.

Malangizo ogwiritsira ntchito

Malinga ndi malangizo ogwiritsa ntchito, mankhwalawo amaloledwa kumwa ndi akulu ndi ana omwe zaka zawo zafika pachaka 9. Kusiyapo ndi atsikana asanakwane msambo woyamba, popeza kafukufuku wokhudzana ndi momwe Fluvastatin amakhudzira mahomoni ogonana achikazi sanachitike.

Mlingo wovomerezeka tsiku lililonse ndi 2040 mg. Ndikofunikira kumwa mankhwalawa madzulo, popeza zochuluka za cholesterol zimapangidwa usiku. Zotsatira zabwino kwambiri zochizira zimawonedwa pakatha masiku 24 kuyambira nthawi yoyamba maphunziro. Munthawi yonse ya chithandizo, ndikofunikira kuwunika momwe milingo yapamwamba kwambiri imayendera.

• 1 kapisozi (40 mg) kapena piritsi limodzi (80 mg) - kamodzi patsiku,
• Makapisozi 2 patsiku - mogwirizana ndi dokotala.

Mlingo woyambirira muubwana ndi 20 mg. Ndi kukula kwa zoyipa, maphunzirowa ayenera kusokonezedwa, pokhapokha ngati zizindikiro zikupitilira kwa sabata limodzi. Fluvastatin analogs ikhoza kuyamba kutengedwa pasanathe milungu iwiri mutasiya kulandira mankhwala ndi woyambitsa woyamba.

Gwiritsani ntchito nthawi yobala mwana

Munthawi yonse ya phwando, kutenga statin ndizoletsedwa kwathunthu. Madokotala amati chinthu chomwe chimagwira sichithandizira kuphatikiza mafuta a cholesterol okha, komanso zinthu zopindulitsa zomwe mwana wosabadwayo amafunikira kuti akule bwino. Palibe maphunziro omwe adachitika pankhaniyi.

Ngati kukula kwa pakati kumachitika panthawi yomwe mukumwa mankhwalawo, ndiye kuti mutatsimikizira, maphunzirowa ayenera kuyimitsidwa nthawi yomweyo. Mkaziyo adzalembedwanso mankhwala ena ovomerezeka. Chithandizo cha fluvastatin sichimachitikanso pakuyamwa. Chidacho chopangidwira chimapita mkaka ndipo chimatha kuvulaza khanda.
Muubwana

Kufikira zaka 9, mankhwalawa ali otsutsana kwathunthu. Pambuyo pake, mlingo umawerengeredwa potengera malingaliro a dokotala. Fluvastatin amalembera anyamata ndi atsikana atatha msambo ngati gawo la zovuta mankhwala. Zizindikiro - okwera mafuta m'thupi, apoliprotein B, heterozygous mabanja hypercholesterolemia. Kuphatikiza apo, chakudya chikulimbikitsidwa.

Kuyanjana kwa mankhwala osokoneza bongo

Mukamapereka mankhwala, ndikofunikira kuganizira momwe zimagwirira ntchito zomwe zimagwira.

Ngati ndi kotheka, mankhwalawa amatha kuthandizidwa ndi analogues. Pankhaniyi, angagwiritsidwe ntchito:

• Pravastatin. Chomwe chimagwira ndi sodium pravastatin. Chipangizocho chimalepheretsa kupanga cholesterol pochepetsa ntchito ya HMG coenzyme A-reductase. Amagwiritsidwa ntchito ngati gawo la chithandizo chovuta, komanso kupewa koyambira kapena kwachiwiri.
• Leskol. Chothandizira chophatikizika ndi fluvastatin. Ndi gawo la gulu la mankhwala a hypolidimic omwe ali ndi hypocholesterolemic kwenikweni. Ndi cholepheretsa cha HMG-CoA reductase, amachepetsa kaphatikizidwe ka cholesterol. Musanayambe chithandizo, ndikofunikira kuyang'ana chiwindi.
• Lovastatin. Piritsi limodzi la malonda limatha kukhala ndi 20/40 mg yogwira ntchito, yomwe ndi lovastatin. Mankhwalawa ali ndi kuchepa kwa lipid. Sikugwiritsidwa ntchito muubwana ndi unyamata, ndikumverera kowonjezereka. Zotsatira zake zimakhala zambiri. Tengani chida chamadzulo nthawi yamadzulo.
• Leskol Forte. Chofunikira chachikulu ndi fluvastatin sodium mchere. Mankhwalawa cholinga chake ndikupondereza kupanga kwa HMG-CoA reductase ndi kuchepetsa kuchuluka kwa cholesterol yomwe imapangidwa. Mphamvu ya mankhwalawa ndi mankhwalawa imadziwika kumapeto kwa sabata lachiwiri la maphunzirowo.

Palinso ma statins am'badwo watsopano:

• Atorvastatin. The yogwira ndi atorvastatin calcium calcium. Chidacho chili ndi hypocholesterolemic athari.
• Simvastatin. Gawo lalikulu ndi simvastatin. Hypolipidemic mankhwala. Potengera momwe mankhwalawo amagwiritsidwira ntchito, kuchepa kwa cholesterol ndi triglycerides kumadziwika. Chidachi chimatha kuyambitsa mavuto osiyanasiyana. Sichikuperekedwa kwa odwala omwe zaka zawo sizinafike zaka 18, panthawi yoyembekezera komanso mkaka wa m'mawere.
• Rosuvastine. Chithandizo chachikulu ndicho mankhwala rosuvastatin. Amatanthauzira kuchepetsa mankhwala a lipid. Sikoyenera kudya ndi zakudya, chifukwa chakudya chimachepetsa kuyamwa kwa malonda. Contraindication ndi m'badwo wa wodwala. Chogwiritsidwachi sichigwiritsidwa ntchito ngati munthu ali ndi zaka 18 kapena ngati wadutsa kale zaka 65.

Mankhwala obwera mwatsopano amatengedwa kamodzi patsiku. Izi ndi zokwanira kupereka mulingo woyenera wa anthu yogwira magazi seramu. Kusiyana kowonjezereka kuchokera kumafanizo am'mbuyomu ndi kuchepa kwa chiwerengero cha lipoproteins yotsika komanso kukwera kwa lipoproteins yapamwamba.

Mayankho ogwiritsa ntchito mankhwalawa ndi ambiri. Ambiri aiwo amalankhula za momwe mankhwalawo amathandizira. Koma njira yotenga statin ndi yayitali ndipo imalimbikitsa wodwala kuti azitsatira zakudya zapadera zochizira.

Kuphatikizika, mawonekedwe omasulidwa

Fluvastatin imapezeka mu mawonekedwe a mapiritsi okhala ndi ntchito. Zithunzi zachikaso, zozungulira, zokhala ndi "LE", "NVR".

Piritsi limodzi la Leskol Forte lili ndi:

• 80 mg fluvastatin (yogwira ntchito)
• cellulose
• hypromellose
• hydroxypropyl cellulose,
• potaziyamu bicarbonate,
• povidone
• magnesium wakuba,
• titanium dioxide (E 171)
• macrogol
• oxide wachikasu wachitsulo (E 172).

Leskol Forte: Zizindikiro zogwiritsidwa ntchito

Fluvastatin amalembedwa kwa odwala omwe sanathandizidwe pachakudya, ndi:

• hypercholesterolemia yoyamba,
• dyslipidemia,
• coronary atherosulinosis odwala matenda a mtsempha wamagazi, ochepa hypercholesterolemia.

Kugwiritsa ntchito mankhwalawa odwala omwe ali ndi matenda a mtima kumakupatsani:

• muchepetse chiwerengero chaimfa mwadzidzidzi chifukwa cha matenda amtima,
• kuchepetsa chiopsezo chokhala ndi myocardial infarction ndi 31%,
• chepetsani kuchuluka kwa kuchitapo kanthu pochita opaleshoni (revascularization, bypass surge).

Zotsatira zabwino za kutenga fluvastatin kwa odwala omwe ali ndi matenda a shuga, komanso zilonda zingapo zamitsempha yama coron, ndizodziwika bwino.

Malangizo a fluvastatin amapereka zambiri kuchokera pa kafukufuku wambiri. Zinawonetsa kuti odwala omwe ali ndi matenda amitsempha yamagazi, kuyang'anira kwa Leskol forte kwa zaka 2.5 (mlingo wa 40 mg), kupititsa kwa coronary atherosulinosis kunali kuyimitsidwa.

Leskol ndi amodzi mwa maumboni ochepa omwe amatha kupatsidwa kwa ana omwe ali ndi cholowa hypercholesterolemia. Itha kutengedwa kuchokera wazaka 9. Zimatsimikiziridwa kuti kutenga fluvastatin sikusokoneza kukula, kukula, kutha msinkhu.

Njira ya ntchito, Mlingo

Zambiri zofunika zomwe wodwala ayenera kudziwa za kutenga fluvastatin:

• tsatirani njira yochepetsera mafuta m'thupi panthawi yonse ya chithandizo. Kupanda kutero, mankhwalawo adzakhala opanda ntchito,
• Leskol Forte iyenera kumwedwa 1 nthawi / tsiku, lathunthu, mosasamala chakudya, nthawi ya tsiku,
• imwani piritsi lililonse ndi kapu yamadzi,
• khalani ndi nthawi y kumwa mankhwalawa, gwiritsitsani nthawi yonseyi,
• ngati mwaphonya kumwa piritsi mwangozi, konzekerani mwachangu. Malinga kuti mpaka maola enanso 12 atsala. Mulibe nthawi? Imwani piritsi lotsatira pa nthawi, osafunikira kuwonjezera mlingo,
• osayiwala kupereka magazi pafupipafupi kuti azilamulira cholesterol. Nthawi yoyamba yomwe amakhala ndikuyesera nthawi zambiri, ndiye -
• lekani mowa.

Mlingo woyenera kwa akuluakulu ndi 80 mg. Ndi mtundu wofatsa wa cholowa cholowa, ana amatenga 20 mg wa fluvastatin tsiku lililonse, ndipo kwambiri - 80 mg.

Kodi fluvastatin amasiyana bwanji ndi ma statin ena?

Gawo lalikulu la ma statin limachotsedwa m'thupi ndi impso. Chifukwa chake, nthenda zawo zimafunikira kusamala mosamala. Leskol Forte sichivomerezeka ndi impso (2% yokha), imatha kulembedwa kwa odwala omwe ali ndi vuto la nephrological.

Kusiyanitsa kwachiwiri kofunikira pakati pa fluvastatin ndi analogues ndikuti kumatetezeka limodzi ndi vitamini B3, colestyramine, fibrate, itraconazole, erythromycin, digoxin, amlodipine, colchicine.

Chifukwa cha zomwe zimachitika nthawi yayitali, Leskol imatha kutengedwa nthawi iliyonse masana. Izi sizikhudza mphamvu ya mankhwalawa.

Anandipatsa Leskol Forte. Tsopano mukuyenera kutenga moyo?

Anthu ambiri amayenera kumwa mankhwala ochepetsa mphamvu ya cholesterol m'miyoyo yawo yonse. Ichi ndichifukwa cha padera pamaumbidwe ochitira. Zovuta zakugwiritsa ntchito ma statins zimangokhala mukuzitenga. Leskol Forte ndi mankhwala okwera mtengo, koma nthawi zonse mutha kufunsa adokotala kuti asankhe analogue.

Maganizo a Madotolo pa fluvastatin

Mankhwalawa ali ndi mphamvu yochepetsa mafuta m'thupi. Atorvastatin, rosuvastatin ndi wamphamvu kwambiri kuposa izi. Leskol Forte imatha kukhala yothandiza kwa odwala omwe ali ndi vuto la impso, ngakhale rosuvastatin sakhalanso yotsutsana nawo.

Kusiyanitsa kwakukulu kwa fluvastatin ndi kutha kuwapatsa ana kwa zaka 9. Mankhwala ena onse amakhala otsutsana kapena amati ndi okalamba.

Zinthu zomwe zidakonzedwa ndi olemba polojekitiyi
malingana ndi ndondomeko yakusinthaku.