Thiogammacene, pezani, gulani

Zina zamalonda zamankhwala: Thiogamma

Dzinalo Lopanda Padziko Lonse: Thioctic acid

Fomu ya Mlingo: mapiritsi, njira yothetsera kulowetsedwa, gwiritsani ntchito kukonzekera kulowetsedwa

Chithandizo: thioctic acid

Gulu la Pharmacotherapeutic:

lipid ndi chakudya kagayidwe kachakudya

Katundu

Pulogalamu yogwira Thiogamm (Thiogamma-Turbo) ndi asidi wa thioctic (alpha-lipoic). Thioctic acid imapangidwa m'thupi ndipo imagwira ntchito ngati coenzyme yopanga mphamvu ya alpha-keto acid ndi oxidative decarboxylation. Thioctic acid imayambitsa kutsika kwa glucose mu seramu yamagazi, imathandizira kuti glycogen ichulukane mu hepatocytes. Mavuto a metabolism kapena kusowa kwa thioctic acid amawonedwa ndikuchulukitsidwa kwambiri kwa metabolites ena mthupi (mwachitsanzo, matupi a ketone), komanso ngati atamwa. Izi zimabweretsa zosokoneza mu unyolo wa aerobic glycolysis. Thioctic acid ilipo mthupi mu mawonekedwe a mitundu iwiri: yochepetsedwa ndikuwonjezeredwa. Mitundu yonseyi ndi yogwira ntchito mwakuthupi, imapereka antioxidant komanso anti-sumu.

Thioctic acid amawongolera kagayidwe kazakudya ndi mafuta, zimakhudza kagayidwe ka cholesterol, imakhala ndi hepatoprotective, ikukweza ntchito ya chiwindi. Zothandiza pa obwezeretsanso njira mu minofu ndi ziwalo. Mankhwala okhala ndi thioctic acid ndi ofanana ndi mavitamini a B. Pamugawo woyamba wa chiwindi, thioctic acid amasintha kwambiri. Mwa kupezeka kwa mankhwalawa, kusinthasintha kwakukulu kumawonedwa.

Ikagwiritsidwa ntchito mkati, imathamanga ndipo imatsala pang'ono kulowa m'mimba. Metabolism imapitilira ndi kukhathamiritsa kwa mbali ya thioctic acid ndi kuphatikizika kwake. Kutha kwa theka-moyo wa Tiogamm (Tiogamm-Turbo) kuyambira 10 mpaka 20 mphindi. Amachotsedwa mu mkodzo, ndi metabolites of thioctic acid predominating.

Zisonyezero zogwiritsidwa ntchito:

Matenda a shuga a polyneuropathy, zakumwa zoledzeretsa.

Zoyipa:

Mimba, kuyamwa, yoyamwitsa, ana osaposa zaka 18, hypersensitivity kuti thioctic acid kapena zigawo zina za mankhwala.

Mlingo ndi makonzedwe:

Thiogma wotsogolera makolo.

Thiogamma cholinga chake ndi makulidwe aubwino mwa kulowetserera kulowerera. Kwa akuluakulu, mlingo wa 600 mg (zomwe zili mu 1 vial kapena 1 ampoule) zimagwiritsidwa ntchito kamodzi patsiku. The kulowetsedwa ikuchitika pang'onopang'ono, kwa mphindi 20-30. Njira yochizira matendawa ndi pafupifupi milungu iwiri kapena inayi. M'tsogolomu, kugwiritsa ntchito kwa Tiogamma m'mapiritsi kumalimbikitsidwa. Makonzedwe a kholo Thiogamm wa kulowetsedwa amapatsidwa matenda osokoneza bongo omwe amachitika chifukwa cha matenda ashuga a polyneuropathy.

Zomwe zili m'botolo 1 la Thiogamma-Turbo kapena 1 ampoule wa Thiogamma (600 mg wa mankhwalawa) zimasungunuka mu 50-250 ml ya yankho la 0.9% sodium chloride. Mlingo wa kulowetsedwa kwa mtsempha - osapitirira 50 mg ya thioctic acid mu miniti imodzi - izi zimafanana ndi 1,7 ml ya njira ya Tiogamm. Kukonzekera kuchepetsedwa kuyenera kugwiritsidwa ntchito mukangosakaniza ndi zosungunulira. Pa kulowetsedwa, njira yothetsera vutoli iyenera kutetezedwa ndikuwala ndi chinthu chapadera choteteza kuwala.

Mapiritsiwo adapangira kuti azigwiritsa ntchito mkati. Ndi bwino kupereka mankhwala a 600 mg kamodzi pa tsiku. Piritsi liyenera kumezedwa lonse, litenge popanda chakudya, kutsukidwa ndi madzi okwanira. Kutalika kwa mankhwalawa kwa mapiritsi kuyambira 1 mpaka miyezi 4.

Zotsatira zoyipa:

Central mantha system: nthawi zina, mutagwiritsa ntchito mankhwalawa ngati kulowetsedwa, kupweteka kwa minofu yolimba ndikotheka.

Zokhudza ziwalo: kuphwanya tanthauzo la kukoma, diplopia.

Hematopoietic dongosolo: purpura (hemorrhagic zidzolo), thrombophlebitis.

Hypersensitivity reaction: systemic zochita zimatha kuyambitsa anaphylactic, eczema kapena urticaria pamalo a jekeseni.

Dongosolo logaya (la mapiritsi a Tiogamm): mawonetseredwe a dyspeptic.

Ena: ngati Tiogamma-Turbo (kapena Tiogamma wa makina oyang'anira makolo) akaperekedwera mwachangu, kupuma kwamphamvu komanso kumverera kovutikira m'mutu ndikotheka - izi zimayima pambuyo pakuchepa kwa kulowetsedwa. Chothekanso: hypoglycemia, kutentha kwa moto, chizungulire, thukuta, kupweteka mumtima, kutsika magazi, kutsukidwa, kuwona kwamaso, mutu, kusanza, tachycardia.

Mogwirizana ndi mankhwala ena:

Thioctic acid amachepetsa mphamvu ya cisplatin pomwe amamwa, komanso amakumana ndi mankhwala okhala ndi chitsulo, monga chitsulo, magnesium.

Thioctic acid imakhudzana ndi mamolekyulu a shuga, ndikupanga maselo osungunuka pang'ono, mwachitsanzo, ndi yankho la levulose (fructose).

Thioctic acid imakulitsa mphamvu yotsutsa-yotupa ya GCS.

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala a thioctic acid ndi insulin kapena pakamwa hypoglycemic, zotsatira zawo zitha kukhala zabwino.

Ethanol ndi metabolites ake amachepetsa mphamvu ya thioctic acid.

Njira yothetsera kulowetsedwa kwa thioctic acid sikugwirizana ndi yankho la dextrose, yankho la Ringer, komanso ndi mayankho omwe amachitika ndi magulu osagwirizana ndi a SH.

Tsiku lotha ntchito: Zaka 5

Mankhwala Okhala Pamalo a Pharmacy: mwakulemba

Wopanga:

Werwag Pharma GmbH & Co KG (Worwag Pharma GmbH & Co KG), Beblingen, Germany.