Diabetesalong - malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito:

Mitengo muma pharmacie opezeka pa intaneti:

Diabetesalong ndi zotumphukira za sulfonylurea zam'badwo wachiwiri, mankhwala a hypoglycemic opaka pakamwa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi otulutsidwa okhazikika (60 mg) ndi mapiritsi osinthika osinthika (30 mg): lathyathyathya, pafupifupi yoyera kapena yoyera, yokhala ndi bevel, marbling imaloledwa, mapiritsi a 60 mg ndi osalala, okhala ndi mzere wogawanika (mu contour ma CD: 1, 2, 3 kapena 6 mapaketi, 20 ma CD, mu makatoni mtolo 1, 3, 5 kapena 6, 30 mg - 10 ma PC. munkhokwe yamatoni atatu kapena 6).

Piritsi limodzi lili:

yogwira mankhwala: gliclazide - 60 mg kapena 30 mg,
othandizira: aerosil (colloidal silicon dioxide), calcium stearate, magome 80 (lactose monohydrate), hypromellose (Metocel K-100 LV CR Premium), talc.

Kuphatikiza apo, mapiritsi omwe amatulutsidwa nthawi yayitali pakapangidwe ka hypromellose - Metolosa 90 SH-100SH.

Zizindikiro zogwiritsidwa ntchito

Kugwiritsidwa ntchito kwa Diabetesalong kumawonetsedwa pochiza matenda amishuga a 2 chifukwa pakalibe mphamvu yokwanira kudya, kuchita masewera olimbitsa thupi komanso kuwonda.

Kuphatikiza apo, mapiritsi otulutsira okhazikika amalembedwa popewa zovuta za matenda osokoneza bongo kuti muchepetse chiopsezo chokhala ndi retinopathy, nephropathy, infarction ya myocardial, sitiroko kudzera muulamuliro wa matenda a shuga a mtundu wa 2.

Contraindication

mtundu 1 shuga
matenda ashuga ketoacidosis, matenda a shuga, matenda ashuga,
Mankhwala othandizira ndi miconazole,
kukanika kwambiri kwa hepatic ndi / kapena kulephera kwa impso,
nthawi yapakati
yoyamwitsa
wazaka 18
kufupika kwa lactase, shuga-galactose malabsorption, lactose tsankho,
kugwiritsa ntchito munthawi yomweyo phenylbutazone kapena danazole,
Hypersensitivity kuti sulfonamides, zotumphukira zina za sulfonylurea, zigawo za mankhwala.

Mosamala, ndikofunikira kupereka Diabetesalong kwa odwala omwe alibe zakudya komanso / kapena osazungulira, kuchepa kwa shuga-6-phosphate dehydrogenase, matenda akulu a mtima dongosolo (kuphatikizapo matenda a mtima, atherosulinosis), hypopituitarism, hypothyroidism, adrenal insufficiency kapena / kapena kulephera kwa chiwindi, kugwiritsa ntchito glucocorticosteroids nthawi yayitali, akuvutika ndi uchidakwa, ukalamba.

Mlingo ndi makonzedwe

Mapiritsi amatengedwa pakamwa, kumeza athunthu, makamaka pakudya kadzutsa, 1 nthawi patsiku.

Mlingo wa mankhwala uyenera kutsimikiziridwa ndi kusankhidwa, poganizira kuchuluka kwa shuga ndi glycosylated hemoglobin m'magazi.

Piritsi limodzi la 60 mg ndilofanana ndi achire zotsatira za mapiritsi 2 a 30 mg. Kulekanitsidwa kwa chiopsezo pamapiritsi a 60 mg amalola, ngati pakufunika, kuigawa m'magawo awiri. Chifukwa cha magawano, theka la piritsi lagundika, siliyenera kutengedwa.

Mlingo wovomerezeka watsiku ndi tsiku: mlingo woyambayo (kuphatikiza odwala opitilira 65) ndi 30 mg, poyankha mokwanira umagwiritsidwa ntchito ngati mankhwala osamalira. Pakakhala kuti palibe glycemic yokwanira, mlingo wa tsiku ndi tsiku uyenera kukhala wofanana (osapitilira nthawi 1 mu masabata 4) ukuwonjezeka mpaka 60, 90 kapena 120 mg. Ngati kuchepa kwa kuchuluka kwa shuga m'magazi sikupezeka pakatha masabata awiri atamwa mapiritsi, ndiye kuti mlingowo ukuwonjezeka pakapita milungu iwiri.

Osamamwa mlingo wapamwamba mutatha kudumpha kamodzi kapena zingapo.

Mlingo wapamwamba tsiku lililonse ndi 120 mg.

Mukamasintha kuchokera kwa wogwiritsa ntchito wina wodwala pakamwa, mlingo wake ndi theka la moyo uyenera kukumbukiridwa.

Ngati mankhwala am'mbuyomu a sulfonylurea ofanana anali ndi moyo wautali, tikulimbikitsidwa kuti mupumule pakumwa Mlingo zingapo musanamwe mankhwala. Izi zimapewera hypoglycemia motsutsana ndi maziko azowonjezera a awiri othandizira a hypoglycemic. Pakupita milungu ingapo, kuwunikira mosamala kuchuluka kwa shuga m'magazi kumafunika.

Mlingo woyambirira wa Diabetesalong uzikhala wa 30 mg nthawi zonse.

Mapiritsi amasonyezedwa limodzi ndi othandizira a hypoglycemic monga biguanides, alpha glucosidase inhibitors kapena insulin.

Odwala ndi aimpso kukanika kufatsa wofatsa kuti azikhala wamphamvu mankhwala, koma mankhwala ayenera kuchitika moyangʻaniridwa ndi achipatala.

Chifukwa odwala omwe ali ndi vuto losakwanira kapena lopanda vuto lililonse, vuto la endocrine lovuta kapena loperewera (hypothyroidism, pituitary and adrenal insuffence), matenda ofooketsa a mtima dongosolo (matenda a mtima, wamba atherosclerosis, carotid arteriossteosis) kapena atachotsa chithandizo cha nthawi yayitali komanso / kapena chithandizo Mlingo wambiri, glucocorticosteroids ali pachiwopsezo cha kukhala ndi hypoglycemia, sayenera kutumikiridwa kuposa 30 mg ya mankhwala patsiku.

Pofuna kupewa zovuta za matenda a shuga nthawi yogwiritsira ntchito mankhwalawa, odwala ayenera kutsatira zakudya zomwe dokotala amalimbikitsa, azichita masewera olimbitsa thupi pokhapokha ngati vutoli likuipiraipira, funsani dokotala nthawi yomweyo.

Zotsatira zoyipa

Kukula kwa hypoglycemia: Zizindikiro - njala yayikulu, thukuta lochuluka, kufooka, khungu, kupweteka mutu, nseru, kusanza, kutopa kwambiri, kusokonezeka kwa tulo, kusokonezeka, kuyankha mochedwa, kuchepa, kupsinjika, kuperewera kwamaso komanso kuyankhula, chisokonezo , aphasia, kunjenjemera, kudziona ngati wopanda thandizo, kupanikizika, kulephera kudziletsa, kusokonezeka kwa malingaliro, chizungulire, kugona, bradycardia, delirium, kupuma kosakhazikika, kupsinjika, nkhawa, tachycardia, kuchuluka kwawowopsa kupsinjika, arrhythmia, angina pectoris, palpitations, kusazindikira, chikomokere, imfa,
Kuchokera m'mimba thirakiti: nseru, kusanza, kupweteka m'mimba, kutsegula m'mimba, kudzimbidwa,
Dermatological zimachitika: kuyabwa, zotupa pakhungu, urticaria, erythema, edema ya Quincke, zotupa za maculopapular, poermal necrolysis, matenda a Stevens-Johnson,
Kuchokera kwa ziwalo za hematopoietic ndi dongosolo la lymphatic: kufupika kwa matendawa - leukopenia, kuchepa magazi, thrombocytopenia, granulocytopenia,
Kuchokera ku hepatobiliary system: kuchuluka kwa zamchere phosphatase, aspartate aminotransferase (ACT), alanine aminotransferase (ALT), kawirikawiri - hepatitis, cholestatic jaundice,
Kuchokera ziwalo zam'malingaliro: kusokonezeka kowoneka kochepa (pafupipafupi kumayambiriro kwa chithandizo),
zina: zotheka (zotsatira zoyipa zoyambitsidwa ndi sulfonylurea zotumphukira) - chiwindi kulephera, agranulocytosis, erythrocytopenia, hemolytic anemia, vasculitis, pancytopenia, hyponatremia.

Malangizo apadera

Poyerekeza ndi kagwiritsidwe ntchito ka Diabetesalong, komanso zotumphukira zina za sulfonylurea, pamakhala chiopsezo cha hypoglycemia. Kuti muimitse chizindikiro chake, wodwalayo ayenera kutenga mankhwala aliwonse okhala ndi chakudya (shuga atha kukhala), m'malo mwa shuga pamenepa sizothandiza.

Pazovuta zamtundu wa hypoglycemia wovuta kwambiri, wodwala amafunikira kuchipatala komanso kuyamwa kwa njira ya dextrose masiku angapo.

Popereka mankhwala, wodwalayo ndi anthu am'banja lake ayenera kudziwitsidwa bwino za kufunika koti azitsatira pafupipafupi zakudya, kuphatikizapo chakudya cham'mawa, kuopsa kwake ndi zizindikiro za hypoglycemia, komanso mikhalidwe yoyenera kukula kwake. Popeza zakudya zosasinthika, zosakwanira kapena zoperewera kwa thupi zimawonjezera mwayi wokhala ndi hypoglycemia, ndikofunikira kwambiri kutsatira malingaliro onse a dokotala.

Kuphatikiza pa zakudya zama calorie ochepa, hypoglycemia nthawi zambiri imayamba chifukwa chokhala ndi nthawi yayitali kapena kuchita masewera olimbitsa thupi, kumwa mowa, kapena kumwa mankhwala angapo a hypoglycemic nthawi imodzi.

Kuyenera kukumbukiridwa kuti kuyambanso kuyambiranso kwa hypoglycemia pambuyo pakupuma bwino koyamba.

Zinthu zotsatirazi zimayambitsa chiwopsezo cha hypoglycemia:

kudandaula kwa wodwala kapena kulephera (nthawi zambiri zaukalamba) kuwongolera mkhalidwe wake ndikutsatira mosamalitsa malangizo a dokotala,
osagwirizana ndi boma komanso zakudya,
kuphwanya bwino pakati pa kudya zakudya zamagulu omwera ndi zochitika zolimbitsa thupi,
munthawi yomweyo kugwiritsa ntchito mankhwala omwe amalimbikitsa kuchuluka kwa vutoli.
kulephera kwambiri kwa chiwindi
kulephera kwa aimpso
matenda a chithokomiro England, adrenal ndi pituitary kusowa,
bongo wa Diabetesalong.

Zosintha mu pharmacokinetic ndi / kapena pharmacodynamic katundu wa gliclazide mwa odwala aimpso ndipo kwa chiwindi kukonzekera kumapangitsa vuto la hypoglycemia pakukula kwake.

Ndikofunika kumwa mankhwalawa podziyang'anitsitsa ndende yamagazi.

Ndi kuchepa kwa glucose-6-phosphate dehydrogenase, mankhwalawa angathandizire kukulitsa kwa hemolytic anemia, chifukwa chake tikulimbikitsidwa kulingalira za mwayi wopatsa hypoglycemic wothandizira wa gulu lina.

Pankhani ya matenda opatsirana kapena opaleshoni yayikulu, kuganiziridwanso kuyenera kuchitika pakuchepetsa kwa mankhwala ndi kuikidwa kwa insulin.

Zomwe zimapangitsa kuti kuchepa kwa Hypoglycemic zotsatira za Diabetesalong atagwiritsidwa ntchito nthawi yayitali kungakhale kuchepa kwamankhwala poyambira komanso kupitirira kwa matendawa. Pozindikira kukana kwachiwiri kwa mankhwala, dokotala amayenera kuyang'anitsitsa kuchuluka kwa kumwa kwa wodwalayo ndikuwonetsetsa kuti akutsatira zakudya zomwe wapatsidwa.

Kumwa mankhwalawa mukamadyetsa chakudya cham'mawa kumachepetsa chiopsezo cha zovuta zam'mimba.

Mu chiwindi chachikulu komanso / kapena kulephera kwaimpso, wodwalayo amalimbikitsidwa kugwiritsa ntchito insulin.

Pokonzekera kutenga pakati kapena kutenga pakati pomwa mankhwala, mkazi akulimbikitsidwa kusinthana ndi insulin.

Popeza kuopsa kwa hypoglycemia, odwala amalangizidwa kuti asamale poyendetsa magalimoto ndi zida zamagetsi pogwiritsa ntchito mankhwalawa.

Kuyanjana kwa mankhwala osokoneza bongo

Ndi munthawi yomweyo kugwiritsa ntchito Diabetesalong:

miconazole imathandizira kwambiri zotsatira za gliclazide,
ndi makonzedwe a dongosolo, phenylbutazone amalimbikitsa kusamutsidwa kwa gliclazide kuchokera kumayanjano ndi mapuloteni a plasma ndipo / kapena kuchedwetsa kutuluka kwa thupi, kukulitsa mphamvu ya Hypoglycemic.
Mowa (kuphatikiza mowa ndi mankhwala omwe amakhala ndi ethanol) umawonjezera chiopsezo cha hypoglycemia, ungayambitse kuperewera kwa hypoglycemic,
othandizira ena a hypoglycemic (insulin, acarbose, metformin, thiazolidinediones, dipeptidyl peptidase-4 zoletsa, glucagon-like peptide-1 receptor agonists), beta-blockers, fluconazole, angiotensin-converting enzyme inhibitors (capopril, blocktopril, ectopril₂- histamine receptors, monoamine oxidase inhibitors, sulfonamides, clarithromycin, omwe si mankhwala a antiidal - amalimbikitsa mphamvu ya hypoglycemic ndi chiwopsezo cha hypoglycemia,
Danazole ali ndi matenda ashuga, amachepetsa zovuta zamankhwala.
Chlorpromazine mu mlingo pamwamba 100 mg patsiku, kuchepetsa chinsinsi cha insulin, kumawonjezera kuchuluka kwa shuga m'magazi,
tetracosactides ndi glucocorticosteroids wothandizika ndi kupakasa ntchito kumachulukitsa kuchuluka kwa shuga m'magazi, kumatha kuchepetsa kulolerana kwa chakudya komanso kumapangitsa kukula kwa ketoacidosis,
salbutamol, ritodrin, terbutaline kwa mtsempha wamitsempha yamagazi kumaonjezera kuchuluka kwa shuga m'magazi,
warfarin ndi ma anticoagulants ena amatha kukulitsa mphamvu.

Diabetesalong analogu ndi: Diabinax, Gliclazide MV, Gliclazide-Akos, Glidiab MV, Diabeteson MV, Glucostabil.

Zotsatira za pharmacological

Oral hypoglycemic mankhwala, omwe amapezeka m'badwo wachiwiri.

Zimapangitsa secretion ya insulin ndi kapamba, imachepetsa kuchuluka kwa glucose m'magazi, imakulitsa mphamvu ya insulin-secretory ya glucose ndikuwonjezera chidwi cha zotumphukira zimakhala ndi insulin. Pambuyo pa chithandizo chazaka ziwiri, odwala ambiri samayamba kumwa mankhwala osokoneza bongo (kuchuluka kwa insulin ndikubisalira kwa C-peptides kumakhalabe.

Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Imabwezeretsa chiyambi choyambirira cha insulin katulutsidwe poyamwa kudya kwa glucose (mosiyana ndi zina za sulfonylurea, zomwe zimakhudza gawo lachiwonetsero chachiwiri). Zimathandizanso gawo lachiwiri la insulin secretion. Kuchepetsa kukwera kwa hyperglycemia mukatha kudya (kumachepetsa postprandial hyperglycemia).

Glyclazide imawonjezera chidwi cha zotumphukira zimakhala ku insulin (i.e., ili ndi kutchulidwa kwa extrapancreatic athari). Mu minofu minofu, mphamvu ya insulini pakukoka kwa glucose, chifukwa cha kusintha kwamphamvu kwa minofu, insulin imakulitsidwa kwambiri (mpaka + 35%), chifukwa glycazide imalimbikitsa ntchito ya minofu ya glycogen synthetase.

Amachepetsa mapangidwe a shuga m'chiwindi, amateteza kusuntha kwa shuga.

Kuphatikiza pa kukhudza kagayidwe kazakudya, gliclazide imathandizanso kukoka kwam'mimba. Mankhwala amachepetsa chiopsezo cha chotupa chamagazi am'magazi, kukhudza magawo awiri omwe angatenge nawo gawo la zovuta za matenda osokoneza bongo: kuletsa kwapang'onopang'ono kwa kuphatikiza kupatsidwa zinthu zam'magazi komanso kutsekeka komanso kuchepa kwa kuchuluka kwa ma cell a activation (beta-thromboglobulin, thromboxane B2) komanso kuchira fibrinolytic ntchito ya mtima endothelium ndi kuwonjezeka ntchito ya minofu plasminogen activator.

Glyclazide ili ndi antioxidant katundu: imachepetsa mulingo wa lipid peroxides mu plasma, imawonjezera ntchito ya maselo ofiira am'magazi a superoxide dismutase.

Chifukwa chazovuta zam'mapiritsi, muyezo umodzi wa mapiritsi a Diabetesalong ® 30 mg patsiku amapereka chithandizo chokwanira cha gliclazide mu plasma ya maola 24.

Pharmacokinetics

Pambuyo pakamwa, gliclazide imadzaza kwathunthu kuchokera m'mimba. Kudya sizimakhudza mayamwidwe. The kuchuluka kwa yogwira mu madzi am`magazi pang'onopang'ono ukuwonjezeka pang'onopang'ono, ukufika pazipita ndi kufika paphiri 6-12 mawola kumwa mankhwala. Kusiyanasiyana kwamunthu aliyense kumakhala kotsika. Ubale pakati pa kumwa ndi kuchuluka kwa mankhwalawa m'magazi am'magazi ndikudalira kwapanthawi.

Kugawa komanso kagayidwe

Plasma kumanga mapuloteni pafupifupi 95%.

Amapukusidwa mu chiwindi ndikuwachotsa makamaka ndi impso. Palibe metabolites yogwira mu plasma.

Kuchotseredwa ndi impso kumachitika makamaka mu mawonekedwe a metabolites, osakwana 1% ya mankhwalawa amachotsedwa osasinthika.

T 1/2 ili pafupifupi maola 16 (maola 12 mpaka 20).

Pharmacokinetics mu milandu yapadera yamankhwala

Okalamba, palibe kusintha kwakukulu pamawonekedwe a pharmacokinetic komwe kumawonedwa.

Mlingo

Mankhwalawa amangogwiritsidwa ntchito pochiza akuluakulu.

Diabetesalong ® 30 mg mapiritsi amasinthidwe otengedwa amatengedwa pakamwa nthawi imodzi / tsiku pakudya kadzutsa.

Kwa odwala omwe sanalandire chithandizo cham'mbuyomu (kuphatikizapo kwa anthu achikulire zaka 65), mlingo woyambira ndi 30 mg. Ndiye kuti mankhwalawa amasankhidwa payekhapayekha mpaka njira yothandizidwa itakwaniritsidwa.

Kusankhidwa kwa Mlingo uyenera kuchitika molingana ndi mulingo wa shuga m'magazi atangoyamba chithandizo. Kusintha kwa mtundu wina uliwonse kumachitika pakatha milungu iwiri.

Mlingo wa tsiku ndi tsiku wa mankhwalawa umatha kukhala 30 mg (1 tabu.) Mpaka 90-120 mg (3-4 tabu.). Mlingo wa tsiku ndi tsiku sayenera kupitirira 120 mg (mapiritsi 4).

Diabetesalong ® ikhoza kusintha mapiritsi a gliclazide otulutsa (80 mg) mu mapiritsi 1 mpaka 4 mapiritsi / tsiku.

Ngati mwaphonya mtundu umodzi kapena zingapo za mankhwalawa, simungatenge kumwa kwakukulu pa tsiku lotsatira (tsiku lotsatira).

Mukasinthira mankhwala ena a hypoglycemic ndi mapiritsi a Diabetalong ® 30 mg, palibe kusintha kwakanthawi. Muyenera kusiya kumwa mankhwala tsiku lililonse ndipo tsiku lotsatira mungayambe kumwa mankhwalawa.

Ngati wodwalayo alandila chithandizo kale ndi sulfonylureas wokhala ndi moyo wautali, ndiye kuti kuwunika mosamala (kuwunika shuga) kwa masabata 1-2 ndikofunikira kupewa hypoglycemia chifukwa chotsatira chotsalira cha chithandizo chotsatira.

Diabetesalong ® ikhoza kugwiritsidwa ntchito limodzi ndi Biguanides, alpha-glucosidase inhibitors kapena insulin.

Odwala wofatsa pang'ono komanso aimpso kulephera, mankhwala zotchulidwa chimodzimodzi Mlingo wa odwala ndi yachibadwa aimpso ntchito. Kulephera kwakukulu kwa aimpso, Diabetesalong ® imatsutsana.

Odwala omwe ali pachiwopsezo cha kukhala ndi hypoglycemia (zakudya zosakwanira kapena zopanda thanzi, zovuta za endocrine zowonongeka - kuchepa kwa thupi ndi vuto la adrenal, hypothyroidism, kuthetsedwa kwa glucocorticosteroids atatha nthawi yayitali komanso / kapena kukonzekera kwadzaoneni, matenda oopsa a mtima dongosolo / IHD, kwambiri carotid arteriosulinosis, kufala kwa matenda atherosclerosis /) tikulimbikitsidwa kugwiritsa ntchito mlingo wochepa (30 mg 1 nthawi / tsiku) la mankhwala a Diabetalong ®.

Zotsatira zoyipa

Hypoglycemia (kuphwanya malamulo a dosing komanso kudya mokwanira): kupweteka mutu, kutopa kwambiri, njala, kutuluka thukuta kwambiri, kufooka, kugona, kukwiya, nkhawa, kusokonekera, kusokonezeka kwa chidwi, kulephera. yang'anani ndi kuchepetsedwa kuchitapo kanthu, kukhumudwa, kuona kwa m'mimba, phokoso, kugwedezeka, kusokonezeka, kusokonezeka kwa malingaliro, chizungulire, kudziona ngati wopanda thandizo, kulephera kudziletsa, kuwongolera, kugwedezeka, kusachita zambiri imelo kupuma, bradycardia, kukomoka, chikomokere.

Kuchokera pamimba: kukhumudwa, kusanza, kutsegula m'mimba, kupweteka kwam'mimba, kudzimbidwa (zovuta za izi zimatsika ndikamadya chakudya), kawirikawiri - chiwindi ntchito (chiwindi, kuchuluka kwa hepatic transaminase, alkaline phosphatase, cholestatic jaundice - amafunikira kusiya mankhwala.

Kuchokera hemopoietic ziwalo: chopinga wa marow hematopoiesis (magazi m'thupi, thrombocytopenia, leukopenia, granulocytopenia).

Thupi lawo siligwirizana: kuyabwa kwa khungu, urticaria, zotupa pakhungu, kuphatikizapo maculopapular ndi ng'ombe zamphongo), erythema.

Zina: kuchepa kwa mawonekedwe.

Zotsatira zoyipa zina za sulfonylurea zotumphukira: erythropenia, agranulocytosis, hemolytic anemia, pancytopenia, alculgic vasculitis, chiwopsezo cha chiwindi.

Mimba komanso kuyamwa

Palibe zinachitikira ndi gliclazide pa nthawi yapakati. Zomwe zimagwiritsidwa ntchito pazinthu zina za sulfonylurea panthawi yapakati ndizochepa.

Mu maphunziro a nyama yothandizira, teratogenic zotsatira za gliclazide sizinadziwikebe.

Kuchepetsa chiopsezo cha kubadwa mwatsopano, kuwongolera koyenera (chithandizo choyenera) cha matenda osokoneza bongo ndikofunikira.

Mankhwala a Oral hypoglycemic pa nthawi yoyembekezera sagwiritsidwa ntchito. Mankhwala osankhidwa pochiza matenda a shuga mwa amayi apakati ndi insulin. Ndikulimbikitsidwa kuti m'malo mankhwalawa pakhale kumwa kwa mankhwala a hypoglycemic omwe ali ndi vuto la insulin pokhapokha ngati muli ndi pakati, komanso ngati kutenga pakati kumachitika pakumwa mankhwalawo.

Poganizira kusowa kwa chidziwitso cha kudya kwa gliclazide mkaka wa m'mawere ndi chiopsezo chotenga neonatal hypoglycemia, kuyamwitsa kumatsutsana ndi mankhwala.

Bongo

Zizindikiro: hypoglycemia, kusokonezeka kwa chikumbumtima, hypoglycemic chikomokere.

Chithandizo: ngati wodwala akudziwa, tengani shuga mkati.

Mwina chitukuko cha matenda oopsa a hypoglycemic, limodzi ndi chikomokere, kukomoka kapena matenda ena amanjenje. Ngati zizindikiro zotere zikuwoneka, chithandizo chamankhwala chodzidzimutsa ndi kuchipatala mwachangu ndikofunikira.

Ngati hypoglycemic coma ikukayikiridwa kapena kupezeka, 50 ml ya 40% dextrose (glucose) yothetsera imalowetsedwa mwachangu kwa wodwala. Kenako, yankho la 5% dextrose (glucose) limayendetsedwa kudzera m'mitsempha kuti magazi azikhala ndi magazi okwanira.

Pambuyo podziwikanso, ndikofunikira kuti mupatse wodwalayo chakudya chambiri m'zakudya zamafuta ochepa (kuti mupewe kukonzanso kwa hypoglycemia). Kuwunikira mosamala kuchuluka kwa shuga wamagazi ndikuwunika kwa wodwalayo kuyenera kuchitidwa kwa maola osachepera 48. Pambuyo pa nthawi yino, kutengera mtundu wa wodwalayo, adokotala amafunikira pakuwunika ntchito zina.

Kutsegula m'mimba sikugwira ntchito chifukwa cha kutchulidwa kwa gliclazide kwa mapuloteni a plasma.

Kupanga ndi mawonekedwe a kumasulidwa

Mapiritsi - 1 piritsi:

Zinthu zomwe zimagwira ntchito: glyclazide - 30 mg, Excipients: hypromellose (Metocel K-100 LV CR Premium), colloidal silicon dioxide (aerosil), calcium stearate, talc, lactose monohydrate (mapiritsi a 80).

Oral hypoglycemic wothandizira, yemwe amapezeka m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Zikuwoneka, zimapangitsa ntchito ya ma intracellular enzymes (makamaka, minofu glycogen synthetase). Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Kubwezeretsanso pachimake cha insulin katulutsidwe, kumachepetsa chiwerengero cha hyperglycemia pambuyo pake.

Glyclazide imachepetsa kuphatikiza kwa maselo ndi kuphatikiza, imachepetsa kukula kwa parietal thrombus, ndikuwonjezera ntchito ya mtima. Matendawa mtima kukhathamira. Ili ndi anti-atherogenic katundu: imatsitsa kuchuluka kwa cholesterol yathunthu (Ch) ndi LDL-C m'magazi, imachulukitsa ndende ya HDL-C komanso imachepetsa kuchuluka kwa zopitilira muyeso. Zimalepheretsa kukula kwa microthrombosis ndi atherosulinosis. Amasintha kusintha kwakachulukidwe. Imachepetsa mphamvu ya mtima ku adrenaline.

Ndi diabetesic nephropathy yogwiritsa ntchito gliclazide nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika.

Pambuyo pakumwa pakamwa, imatengedwa mwachangu kuchokera mumimba. C max m'magazi amafikira pafupifupi maola 4 atatha kumwa kamodzi kwa 80 mg.

Kumanga mapuloteni a Plasma ndi 94.2%. V d - pafupifupi 25 l (0,35 l / kg thupi).

Zimapangidwa mu chiwindi ndikupanga 8 metabolites. Metabolite yayikulu ilibe mphamvu ya hypoglycemic, koma imakhudza ma microcirculation.

Maola a T1 / 2 - 12. Amapukusidwa makamaka ndi impso mu mawonekedwe a metabolites, osakwana 1% omwe amaponyedwa mkodzo osasinthika.

Oral hypoglycemic mankhwala.

Gliclazide imagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe samatengera insulin kuphatikiza ndi zakudya zama calorie ochepa, zama carb ochepa.

Pa chithandizo, muyenera kuwunika kuchuluka kwa shuga m'magazi pamimba yopanda kanthu ndikatha kudya, kusinthasintha kwa tsiku ndi tsiku m'magazi a shuga.

Pankhani ya chithandizo cha opaleshoni kapena kuwonongeka kwa matenda a shuga, ndikofunikira kulingalira kuti mwina mungagwiritse ntchito insulin pokonzekera.

Ndi chitukuko cha hypoglycemia, ngati wodwalayo akudziwa, shuga (kapena yankho la shuga) amapatsidwa mkati. Pofuna kutaya chikumbumtima, glucose wamitsempha kapena glucagon sc, intramuscularly kapena kudzera m'mitsempha amathandizira. Pambuyo podziwikanso, ndikofunikira kuti wodwalayo adye chakudya chamagulu ambiri kuti mupewe kukonzanso kwa hypoglycemia.

Pogwiritsa ntchito munthawi yomweyo gliclazide yokhala ndi verapamil, kuyang'anira kuchuluka kwa shuga m'magazi kumafunika, ndi acarbose, kuyang'anira mosamala ndi kuwongolera kwa dongosolo lothandizira la hypoglycemic.

Kugwiritsa ntchito pamodzi gliclazide ndi cimetidine osavomerezeka.

Kutetezedwa Kutulutsidwa Mapiritsi, 30 mg

Piritsi limodzi lili

yogwira mankhwala ndi gliclazide - 30 mg,

zotuluka: hypromellose, colloidal silicon dioxide, calcium yochepa, talc, lactose monohydrate

Mapiritsi ndi oyera kapena pafupifupi oyera, osalala, okhala ndi bevel. Kukhalapo kwa "mozungulira" ndikuloledwa

Mankhwala

Pambuyo pakamwa, gliclazide imadzaza kwathunthu kuchokera kumimba. Kudya sizimakhudza mayamwidwe. The kuchuluka kwa yogwira mu madzi am`magazi pang'onopang'ono ukuwonjezeka pang'onopang'ono, ukufika pazipita ndi kufika paphiri 6-12 mawola kumwa mankhwala. Kusiyanasiyana kwamunthu aliyense kumakhala kotsika. Ubale pakati pa kumwa ndi kuchuluka kwa mankhwalawa m'magazi am'magazi ndikudalira kwapanthawi.

Kuyankhulana ndi mapuloteni a plasma pafupifupi 95%.

Amapukusidwa mu chiwindi ndikuwachotsa makamaka ndi impso. Kuchotseredwa ndi impso kumachitika makamaka mu mawonekedwe a metabolites, osakwana 1% ya mankhwalawa amachotsedwa osasinthika.

Palibe metabolites yogwira mu plasma. Hafu ya moyo imakhala pafupifupi maola 16 (maola 12 mpaka 20).

Okalamba, palibe kusintha kwakukulu pamawonekedwe a pharmacokinetic komwe kumawonedwa.

Diabetalong® ndi othandizira a hypoglycemic, omwe amachokera m'badwo wachiwiri.

Amachepetsa mapangidwe a shuga m'chiwindi, amateteza kusuntha kwa shuga.

Kuphatikiza pa kukhudza kagayidwe kazakudya, gliclazide imathandizanso kukoka kwam'mimba. Mankhwala amachepetsa chiopsezo chaching'ono chotupa cha thrombosis, chikukhudza njira ziwiri zomwe zingakhudzidwe ndikupanga zovuta m'matenda a shuga: kusakanikirana kwakanthawi kwa kupatsidwa zinthu za m'magazi komanso kuzitsatira komanso kuchepa kwa kugwiritsidwa ntchito kwa zinthu zamagulu a cell (beta-thromboglobulin, thromboxane B2), komanso kubwezeretsa fibrinolytic B2) mtima endothelial ntchito ndi kuchuluka kwa minofu plasminogen activator.

Glyclazide ili ndi antioxidant katundu: imachepetsa mulingo wa lipid peroxides mu plasma, imawonjezera ntchito ya maselo ofiira am'magazi a superoxide dismutase.

Chifukwa chazachilendo ndi mawonekedwe a mapiritsi, tsiku lililonse mapiritsi a Diabetesalong® 30 mg amapereka njira yothandizira yochizira gliclazide mu madzi am'magazi kwa maola 24.

Kuphatikizika, mawonekedwe omasulidwa

Diabetesalong imapezeka ngati mapiritsi oyera ozungulira. Zodzazidwa ndi matuza a zidutswa 10 ndi kabokosi kamakatoni, pomwe pamakhala ma mbale atatu mpaka 6.

Mankhwalawa amapezeka pamiyeso iwiri: 30 mg ndi 60 mg yogwira ntchito, yomwe ndi gliclazide.

Zothandiza pa mankhwala:

colloidal silicon dioxide,
lactose monohydrate,
calcium owawa
pyromellose
talcum ufa.

Fomu ya mankhwalawa itha kukhala ngati mapiritsi okhala ndi kutulutsidwa kosinthika kapena kuchitapo kanthu kwanthawi yayitali.

Pharmacology ndi pharmacokinetics

Chofunikira chachikulu ndi gliclazide, mwachilengedwe ndimtundu wa sulfonylurea wachiwiri. Gliclazide imawonetsa kusankha kwakukulu kosankha ndi bioavailability.

Amagwirizana ndi zovuta zachilengedwe ndipo zimakhala zotsatirazi:

kumawonjezera kupanga kwake kwa insulini, kukulolani kuti muchepetse muyezo wa mahomoni omwe mumabayidwa,
amateteza kagayidwe kazakudya,
kumawonjezera ntchito ya maselo a kancreatic pancreatic,
amachepetsa kupatsidwa zinthu za m'magazi, zomwe zimalepheretsa thrombosis ndi ma cell ena a mtima.

Diabetesalong kwathunthu odzipereka pambuyo makonzedwe. Pang'onopang'ono kudziunjikira m'magazi, kufika pazowonjezera ndende maola 4-6 pambuyo pa utsogoleri, kuwonetsa momwe zimakhalira kwa maola 10-12, ndiye kuti kuchuluka kwake kumachepa kwambiri ndipo pambuyo maola 12 mankhwala amachotsedwa kwathunthu m'thupi.

Gliclazide imapangidwa makamaka ndi chiwindi, ndikuwachotsa impso.

Zizindikiro ndi contraindication

Chifukwa chotenga Diabetesalong ndikozindikira kwa wodwala - mtundu wachiwiri wa matenda ashuga. Mankhwala amathandizidwa kutsitsa shuga m'magazi akamagwiritsira ntchito zoletsedwa zomwe sizingathandize.

Komanso, mankhwalawa amalembedwa ngati prophylactic pazovuta zomwe zimayambitsidwa ndi matenda a shuga, makamaka amasintha kapangidwe ka mitsempha ya magazi mothandizidwa ndi glycemia yayikulu.

Pali ma contraindication a mankhwalawa, akuphatikiza:

mtundu 1 shuga
kutenga miconazole,
kukanika kwambiri kwa hepatic ndi aimpso,
nthawi ya pakati komanso yoyamwitsa,
kupezeka kwa matenda ashuga a ketoacidosis, chikomokere,
kukhudzika kwakukulu pazinthu zomwe zimapanga mankhwala,
kuphwanya lactose kagayidwe,
zaka mpaka kukula.

Chenjezo ndipo pokhapokha moyang'aniridwa ndi dokotala, mankhwalawa amagwiritsidwa ntchito:

muukalamba
anthu omwe zakudya zawo sizipezeka,
odwala ndi mtima zotupa,
odwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase,
atatenga nthawi yayitali glucocorticosteroid mankhwala,
zidakwa
kukhala ndi vuto la impso kapena chiwindi.

Pankhaniyi, adotolo ayenera kupanga chisankho pamaziko a deta yomwe ilipo.

Zambiri pazakanema kuchokera kwa akatswiri azamankhwala:

Malangizo ogwiritsira ntchito

Mlingo komanso pafupipafupi kugwiritsa ntchito Diabetesalong ndi omwe adalembedwa ndi dokotala, zimatengera magawo a wodwalayo ndipo amatha kusiyanasiyana kwambiri kuchokera pamunthu wina ndi mnzake.Malinga ndi malangizo, phwando limachitika kawiri pa tsiku kwa mphindi 20 asanadye. Njirayi imalola kugwiritsidwa ntchito moyenera kwa gliclazide.

Mankhwalawa amatengedwa pakamwa ndikutsukidwa ndi madzi pang'ono. Mlingo umatsimikiziridwa ndi njira yosankhira. Pankhaniyi, muyenera kuyamba ndi 30 mg patsiku, ngati palibe chithandizo chamankhwala, mlingo umachulukitsidwa pang'onopang'ono ndi 30 mg mpaka 120 mg. Uwu ndiye muyeso wabwino kwambiri pamwambapa omwe osavomerezeka ali osavomerezeka.

Simungathe kuwonjezera pawokha ngati njira imodzi idasowa, chifukwa mankhwalawa amatsogolera kuchepa kwa shuga wamagazi, omwe angayambitse hypoglycemia.

Odwala apadera

Kwa okalamba opitilira 65, kusintha koyenera kungafunike. Mwambiri, mankhwalawa amagwiritsidwa ntchito molingana ndi malamulo omwewo.

Munthawi ya bere, mankhwalawa amalimbikitsidwa kuti asinthidwe ndi insulin mankhwala mpaka pobereka. Palibe chokuchitikirani pakugwiritsa ntchito mankhwala a Diabetalong ndi mankhwala ena a glycoside pa nthawi yoyembekezera, chifukwa chake ndizosatheka kudziwa momwe zimayambira mwana wosabadwayo.

Pa mkaka wa m`mawere, mankhwalawa sangathe kugwiritsidwa ntchito, popeza pali mwayi wokhala ndi neonatal hypoglycemia mwa mwana. Chifukwa chake, kuyamwitsa mayi wodwala ndikuloledwa.

Odwala omwe ali ndi vuto la aimpso ndi ma pathologies ena ayenera kutsatira miyeso yotsika, koposa zonse, kuyang'aniridwa ndi adokotala.

Kuchita ndi mankhwala ena

Diabetesalong ikuyanjana mwachangu ndi zinthu zambiri, kotero musanayambe kumwa, muyenera kuzolowera izi.

Chifukwa chake, ngati munkakhala munthawi yomweyo:

ndi mowa ungayambitse hypoglycemia,
ndi Danazol, matenda a shuga amawonekera, omwe amachepetsa mphamvu ya mankhwalawo.
ndi miconazole, mphamvu ya gliclazide imalimbikitsidwa, yomwe imathandizira pakupanga hypoglycemia, zomwezi zimachitika ndi ena othandizira a hypoglycemic,
ndi chlorpromazine, yomwe imachepetsa kupanga insulin, mphamvu ya mankhwala imachepetsedwa,
ndi tetracosactide ndi glucocorticosteroids zingayambitse kukulira kwa ketoacidosis ndi kuchepa kwa kulolerana kwa carbohydrate,
ndi Wafarin ndi ma coagulants ena amathandizira zotsatira zake.

Ndemanga za madotolo zikuwonetsa kuti Diabetesalong ndiwothandiza kwambiri pakuchepetsa magazi, komabe, sangathe kugwiritsidwa ntchito nthawi zonse.

Pankhaniyi, analogues a Diabetesalong ndi omwe amapatsidwa, omwe ndi ambiri:

Diabetesalong ndi Diabeteson amapangidwa pamaziko a zomwe zimagwiritsidwa ntchito, koma mankhwala wachiwiri amawerengedwa kuti ndi othandiza, chifukwa zotsatira zake zimachitika mwachangu, koma mtengo wa mankhwalawa ndiwonjezeredwe maulendo awiri. Glyclazide ndi analogue yathunthu.

Glucophage yayitali imakhala ndi metformin pakapangidwe kake ndipo imatha kuphatikizidwa ndi insulin ndi mankhwala ena kuti muchepetse shuga.