Mildronate® (500 mg) Meldonium

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Mildronate. Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogwiritsa ntchito mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Mildronate pamachitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, mwina sizinalengezedwe ndi wopanga. Analogs a Mildronate pamakhala mapangidwe ena ofunikira. Gwiritsani ntchito kuchitira matenda a mtima ndi mikwingwirima ndikusintha kagayidwe kazinthu zazikulu mu ana, ana, komanso pa nthawi ya bere.

Mildronate - mankhwala amene bwino kagayidwe. Meldonium (chinthu chomwe chimagwiritsidwa ntchito ngati mankhwala a Mildronate) ndi analogue yochita kupanga ya gamma-butyrobetaine, chinthu chomwe chimapezeka mu khungu lililonse laanthu.

Pazinthu zowonjezereka, Mildronate amabwezeretsa kuchuluka pakati pa kubereka ndi kuchepa kwa okosijeni m'maselo, amachotsa kudziunjikira kwa zophatikiza kagayidwe kachakudya m'maselo, kuwateteza kuti asawonongeke, komanso ali ndi mphamvu. Chifukwa chakugwiritsa ntchito, thupi limatha kulimbana ndi katunduyo ndikuwabwezeretsanso mphamvu zamagetsi. Chifukwa cha malo awa, Mildronate amagwiritsidwa ntchito pochiza matenda osiyanasiyana amtima wamatenda, magazi kupita ku ubongo, komanso kukulitsa kugwira ntchito kwamthupi ndi kwamaganizidwe.

Zotsatira zakuchepa kwa ndende ya carnitine, gamma-butyrobetaine yokhala ndi masodilating amapangidwe kwambiri. Mukuwonongeka kwak pachaka kwa ischemic myocardial, Mildronate amachepetsa mapangidwe a necrotic zone, amafupikitsa nthawi yokonzanso.

Pakulephera kwa mtima, mankhwalawa amathandizira kukomoka kwa mtima, kumawonjezera kulekerera, ndikuchepetsa pafupipafupi matenda a angina.

Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic.

Kugwiritsa kwa mtima ndi dystrophic matenda a fundus.

Mankhwala amathetsa magwiridwe antchito amanjenje, kukulira motsutsana ndi maziko azakumwa zaukali kwa odwala omwe ali ndi uchidakwa woperewera.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, mankhwalawa amatengedwa mwachangu kuchokera mumimba. Amapukusidwa mthupi ndikupanga ma metabolites awiri akuluakulu omwe amatsitsidwa ndi impso.

Zizindikiro

• Mu zovuta mankhwala a matenda a mtima (angina pectoris, myocardial infarction), matenda a mtima, kusungika kwa mtima,
• Mu zovuta za matenda a pachimake ndi matenda a cerebrovascular (stripes ndi cerebrovascular insufficiency),
• Kuchepetsa magwiridwe
• kupsinjika kwakuthupi (kuphatikiza pakati pa othamanga),
• kusiya kwa matenda osokoneza bongo mosalekeza (kuphatikiza mankhwala ena auchidakwa),
• hemophthalmus, retinal hemorrhages a osiyanasiyana etiologies,
• thrombosis yam'kati mwa mtsempha wa retina ndi nthambi zake,
• retinopathies osiyanasiyana etiologies (matenda ashuga, hypertonic).

Kutulutsa Mafomu

Makapisozi 250 mg ndi 500 mg (nthawi zina amatchedwa mapiritsi molakwika, koma mawonekedwe a mapiritsi a Mildronate kulibe)

Njira yothetsera kubayira, ma intramuscular and parabulbar (jakisoni muma ampoules).

Malangizo ogwiritsira ntchito ndi mtundu wa mankhwala

Pokhudzana ndi kuthekera kotukuka kotheka, mankhwalawa amalimbikitsidwa kuti agwiritsidwe ntchito m'mawa.

Kwa matenda amtima monga gawo la zovuta mankhwala, mankhwalawa ndi mankhwala 0,5-1 g tsiku lililonse, pafupipafupi ntchito ndi 1-2. Njira ya mankhwalawa ndi milungu 4-6.

Ndi cardialgia motsutsana maziko a sitormonal myocardial dystrophy, Mildronate amamutsatira pakamwa 250 mg kawiri pa tsiku. Njira ya chithandizo ndi masiku 12.

Pankhani ya ngozi ya cerebrovascular mu gawo pachimake, mankhwala kutumikiridwa m`nsinga (mu yoyenera mlingo - 500 mg kamodzi patsiku kwa masiku 10), ndiye kuti amayamba kumwa mankhwalawo mkati ndi 0,5-1 g patsiku. Njira yodziwika bwino yochitira mankhwalawa ndi milungu 4-6.

Pamavuto osaneneka a kufalikira kwa matenda a chithokomiro, mankhwalawa amatengedwa pakamwa pa 0.5-1 g patsiku. Njira yodziwika bwino yochitira mankhwalawa ndi milungu 4-6. Maphunziro obwerezedwayo amakhazikitsidwa kamodzi pachaka 2-3.

Kuti muchite masewera olimbitsa thupi ndimaganizo, mumakhazikitsidwa 250 mg 4 pa tsiku. Njira ya mankhwala ndi masiku 10-14. Ngati ndi kotheka, mankhwalawa amabwerezedwa pambuyo pa masabata awiri ndi atatu.

Ochita masewera amalimbikitsidwa kugwiritsa ntchito 0,5-1 g kawiri pa tsiku musanaphunzire. Kutalika kwa maphunzirowo pakukonzekera ndi masiku 14-21, panthawi ya mpikisano - masiku 10-14.

Wopanda uchidakwa, mankhwalawa mankhwala 500 mg 4 kawiri pa tsiku. Njira ya chithandizo ndi masiku 7-10.

Kwa matenda a mtima monga gawo la zovuta mankhwala, mankhwala amathandizidwa ndi 0,5-1 g tsiku tsiku kudzera mu mnofu (5-10 ml ya jekeseni wambiri ndi 500 mg / 5 ml), pafupipafupi kugwiritsa ntchito nthawi 1-2 patsiku. Njira ya mankhwala ndi milungu 4-6.

Pankhani ya ngozi ya misempha yodwala kwambiri mu gawo lachiwopsezo, mankhwalawa amatumizidwa ndi iv 500 mg kamodzi patsiku kwa masiku 10, ndiye kuti amayamba kumwa mankhwalawo mkati (mwanjira yoyenera, 0,5-1 g patsiku). Njira yodziwika bwino yochitira mankhwalawa ndi milungu 4-6.

Pankhani ya mtima matenda ndi dystrophic retinal matenda, Mildronate chikuyendetsedwera parabulbarly mu 0,5 ml ya jakisoni ndi ndende ya 500 mg / 5 ml kwa masiku 10.

Kwa kupsinjika kwamaganizidwe ndi thupi, iv imayikidwa 500 mg kamodzi patsiku. Njira ya mankhwala ndi masiku 10-14. Ngati ndi kotheka, mankhwalawa amabwerezedwa pambuyo pa masabata awiri ndi atatu.

Wopanda uchidakwa, mankhwalawa mankhwala 500 mg 2 kawiri pa tsiku. Njira ya chithandizo ndi masiku 7-10.

Zotsatira zoyipa

• tachycardia
• kusintha kwa kuthamanga kwa magazi
• Psychotor
• mutu
• Zizindikiro zam'maso
• thupi lawo siligwirizana (redness of the khungu, zidzolo kapena zotupa, kuyabwa pakhungu, kutupa),
• kufooka wamba
• kutupa.

Contraindication

• kuchuluka kwachuma kwachuma (kuphatikiza pa vuto la chotupa chakutuluka, zotupa za intracranial),
• ana ndi achinyamata osakwana zaka 18,
• Hypersensitivity mankhwala.

Mimba komanso kuyamwa

Chitetezo pakugwiritsa ntchito Mildronate pa nthawi ya pakati sichinatsimikizidwe. Pofuna kupewa kuyipa kwa mwana wosabadwa, mankhwalawa sayenera kutumikiridwa panthawi yomwe ali ndi pakati.

Sizikudziwika ngati mankhwalawa amuchotsa mkaka wa m'mawere. Ngati kuli kofunikira kugwiritsa ntchito Mildronate pa mkaka wa m`mawere, kuyamwitsa kuyenera kuyimitsidwa.

Malangizo apadera

Odwala omwe ali ndi matenda a chiwindi ndi impso ayenera kusamala ndikugwiritsa ntchito mankhwalawa kwa nthawi yayitali. Ngati mukufuna kugwiritsa ntchito mankhwalawa kwa nthawi yayitali (kupitirira mwezi umodzi), muyenera kufunsa katswiri.

Pazaka zambiri pazamankhwala osokoneza bongo oopsa komanso osakhazikika a angina m'madipatimenti a mtima akuwonetsa kuti Mildronate si mankhwala oyamba a matenda apachimake.

Kugwiritsa Ntchito Kwa Ana

Mwa ana ndi achinyamata ochepera zaka 18, kugwiritsa ntchito bwino ndi chitetezo cha Mildronate mwa mawonekedwe a makapisozi ndi jakisoni sizinakhazikitsidwe.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Palibe umboni wotsutsa wa Mildronate pa kuchuluka kwa zomwe psychomotor anachita.

Kuyanjana kwa mankhwala osokoneza bongo

Akaphatikizidwa, Mildronate imathandizira machitidwe a antianginal, mankhwala ena a antihypertgency, mtima glycosides.

Mildronate ikhoza kuphatikizidwa ndi antianginal mankhwala, anticoagulants ndi antiplatelet agents, antiarrhythmic mankhwala, okodzetsa, bronchodilators.

Mukaphatikizidwa ndi Mildronate nitroglycerin, nifedipine, alpha-blockers, antihypertensive mankhwala ndi zotumphukira vasodilators, tachycardia wolimbitsa, hypotension yozungulira imatha kukhazikika (kusamala kuyenera kugwiritsidwa ntchito pophatikiza izi).

Analogs a mankhwala Mildronate

Zofanana muzochitika zamagulu:

• 3- (2,2,2-Trimethylhydrazinium) propionate dihydrate,
• Vasomag
• Idrinol
• Cardionate
• Medatern
• Meldonium,
• Meldonius Eskom
• Meldonium dihydrate,
• Melfort,
• Midolat
• Trimethylhydrazinium propionate dihydrate.

Mlingo

Mmodzi kapisozi muli

ntchito yogwira - meldonium dihydrate 500 mg,

obwera: wowuma mbatata wowuma, colloidal silicon dioxide, calcium stearate,

kapisozi (thupi ndi kapu): titanium dioxide (E 171), gelatin.

Makapisozi olimba a gelatin No. 00 oyera. Zomwe zili ndi ufa wowoneka ngati kristalo wonunkhira bwino. The ufa ndi hygroscopic.

Mankhwala

Pharmacokinetics

Pambuyo pakamwa kamodzi pa meldonium, pazipita plasma ndende (Cmax) ndi malo omwe ali munthawi ya ndende (AUC) amawonjezeka molingana ndi mlingo womwe umayikidwa. Nthawi yakukwanira ndende ya plasma (tmax) ndi maola 1-2. Pogwiritsa ntchito mobwerezabwereza, ndende yolingana ndi plasma imakwaniritsidwa patatha maola 72-96 mutatha kugwiritsa ntchito koyamba mlingo. Kudzikundikira kwa meldonium mu madzi a m'magazi ndikotheka. Chakudya chimachepetsa kuyamwa kwa meldonium popanda kusintha Cmax ndi AUC.

Meldonium yochokera m'magazi imafalikira msanga. Plasma womanga mapuloteni ukuwonjezeka nthawi pambuyo mlingo makonzedwe. Meldonium ndi metabolites ake pang'ono ndi pang'ono zotsekera zotchinga. Kafukufuku wokhudza kupukusa kwa meldonium mkaka wa m'mawere a anthu sanachitike.

Meldonium imapangidwa makamaka mu chiwindi.

Kuchira kwa renal kumathandizira kwambiri pakuchotsa kwa meldonium ndi metabolites. Kuchotsa hafu ya moyo wa meldonium (t1 / 2) ndi pafupifupi maola 4. Ndi Mlingo wobwereza, theka-moyo ndiwosiyana.

Magulu apadera a odwala

Odwala okalamba

Mlingo wa meldonium uyenera kuchepetsedwa mwa okalamba omwe ali ndi vuto la chiwindi kapena impso, omwe ali ndi chiwonetsero chambiri.

Odwala ndi mkhutu aimpso ntchito

Odwala omwe ali ndi vuto laimpso, omwe ali ndi bioavailability, ayenera kuchepetsa mlingo. Pali mgwirizano wa impso reabsorption ya meldonium kapena metabolites (mwachitsanzo, 3 - hydroxymeldonium) ndi carnitine, chifukwa chotsatira chomwe aimpso akuwonjezeka. Palibe zotsatira zachindunji za meldonium, GBB, ndi kuphatikiza kwa meldonium / GBB pa renin-angiotensin-aldosterone system.

Odwala omwe ali ndi vuto la chiwindi

Odwala omwe ali ndi vuto la chiwindi, omwe ali ndi kuchuluka kwa bioavailability, ayenera kuchepetsa mlingo wa meldonium. Kusintha kwa zisonyezo za chiwindi mwa anthu mutagwiritsidwa ntchito Mlingo wa 400-800 mg sizinachitike. Kulowetsedwa kwamafuta m'maselo a chiwindi sikungatheke.

Palibe chidziwitso chachitetezo cha magwiritsidwe ntchito a ana ndi achinyamata (osakwana zaka 18), kotero kugwiritsa ntchito meldonium m'gululi kuli ndi zotsutsana.

Mankhwala

Meldonium imayambira kutsogolo kwa carnitine, analogue yojambula ya gamma-butyrobetaine (GBB), yomwe atomu imodzi ya kaboni imasinthidwa ndi atomu ya nayitrogeni.

Pazinthu zowonjezereka, meldonium imabwezeretsa malire pakati pa kubereka ndi kuchepa kwa mpweya m'maselo, imachotsa kudziunjikira kwa zinthu zopangidwa ndi poizoni m'maselo, kuziteteza kuti zisawonongeke, komanso kukhala ndi mphamvu yamphamvu. Chifukwa chakugwiritsa ntchito, thupi limatha kulimbana ndi katunduyo ndikuwabwezeretsanso mphamvu zamagetsi. Chifukwa cha malo awa, meldonium imagwiritsidwa ntchito pochiza matenda osiyanasiyana amtima wamatenda, magazi kupita ku ubongo, komanso kukulitsa kugwira ntchito kwakuthupi ndi kwamaganizidwe. Zotsatira zakuchepa kwa ndende ya carnitine, GBB, yomwe ili ndi katundu wa vasodilating, imapangidwa kwambiri. Ngati pachimake kuwonongeka kwa myocardium, meldonium imachepetsa mapangidwe a necrotic zone ndikufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina. Mu pachimake komanso matenda a ischemic matenda amitsempha yamagazi amatulutsa magazi mozungulira ischemia, amathandizira kugawa magazi mokomera dera la ischemic. Pankhani ya vuto la mitsempha (pambuyo pa kuwonongeka kwa cerebrovascular, opaleshoni ya ubongo, kuvulala pamutu, encephalitis yodwala), zimakhudza bwino kuwongolera kwa ntchito zolimbitsa thupi komanso luntha panthawi yobwezeretsa.

Zizindikiro zogwiritsidwa ntchito

Ovuta mankhwala otsatirawa milandu:

matenda a mtima ndi mtima dongosolo: angina okhazikika, mtima kulephera (I-III zinchito kalasi NYHA), mtima, matenda a mtima ndi mtima dongosolo.

pachimake komanso chovuta cha ischemic matenda am'mimba,

Kuchepa kwa magwiridwe antchito, thupi

pochira matenda amisala, kuvulala pamutu ndi encephalitis.

Mlingo ndi makonzedwe

Lowetsani mkati. Kapisozi kamizidwa ndi madzi. Mankhwalawa amatha kugwiritsidwa ntchito musanadye kapena mutatha kudya. Pokhudzana ndi zotheka kusintha, mankhwalawa amathandizidwa kuti azigwiritsidwa ntchito m'mawa.

Akuluakulu

Matenda a mtima ndi mtima,ngozi yamitsempha

Mlingo ndi 500-1000 mg patsiku. Mlingo wa tsiku ndi tsiku utha kugwiritsidwa ntchito nthawi imodzi kapena kugawidwa pawiri. Mlingo wambiri watsiku ndi tsiku ndi 1000 mg.

Kuchepetsa ntchito, kuchuluka kwa nthawi komanso kuchira

Mlingo ndi 500 mg patsiku. Mlingo wambiri watsiku ndi tsiku ndi 500 mg.

Kutalika kwa chithandizo ndi masabata a 4-6. Njira ya mankhwalawa imatha kubwerezedwa katatu pachaka.

Odwala okalamba

Okalamba okalamba omwe ali ndi vuto la chiwindi ndi / kapena ntchito ya impso angafunike kuchepetsa mlingo wa meldonium.

Odwala ndi mkhutu aimpso ntchito

Popeza mankhwalawa amathandizidwa kudzera mu impso, odwala omwe ali ndi vuto laimpso kuyambira wofatsa mpaka wolimba ayenera kugwiritsa ntchito kuchepa kwa meldonium.

Odwala omwe ali ndi vuto la chiwindi

Odwala ofatsa pang'ono kwa chiwindi kuwonongeka ayenera kugwiritsa ntchito yochepa mlingo wa meldonium.

Chiwerengero cha ana

Palibe chidziwitso chokhudza chitetezo cha mwana ndi achinyamata pazaka zopitilira 18, chifukwa chake kugwiritsa ntchito mankhwalawa kwa ana ndi achinyamata kumatsutsana.

Zotsatira zoyipa

- hypersensitivity, Matupi a khungu, totupa (General / macular / papular), kuyabwa, urticaria, angioedema, anaphylactic reaction

- Woukitsa, mantha a mantha, malingaliro owonera, kusokonezeka kwa tulo

- paresthesia, hypesthesia, tinnitus, vertigo, chizungulire, kusokonezeka kwakamwa, kukomoka, kusazindikira

- kusintha kwa kayendedwe ka mtima, palpitations, tachycardia / sinus tachycardia, fibrillation wa atria, arrhythmia, kusokonezeka pachifuwa / kupweteka pachifuwa

- kusinthasintha kwa kuthamanga kwa magazi, matenda oopsa, Hyperemia, kuchepa kwa khungu

- zilonda zapakhosi, chifuwa, dyspnea, ziphuphu

- dysgeusia (kulumidwa kwachitsulo mkamwa), kusowa kwa chilimbikitso, kusanza, nseru, kusanza, kudzikundikira kwa mpweya, kutsekula m'mimba, kupweteka m'mimba, - kupweteka kumbuyo, kufooka kwa minofu, minyewa

- kufooka wamba, kunjenjemera, asthenia, edema, kutupa kwa nkhope, kutupa kwamiyendo, kumva kutentha, kumva kuzizira, thukuta lozizira

- zopatuka mu electrocardiogram (ECG), kuthamanga kwa mtima, eosinophilia

Contraindication

- Hypersensitivity to the yogwira mankhwala kapena kuzinto zothandizira za mankhwala.

- kuwonjezeka kwa kuthina kwa intracranial (kuphwanya venous outflow, intracranial tumors).

- Kulephera kwa chiwindi ndi / kapena kulephera kwaimpso chifukwa chosowa chitetezo chokwanira.

- mimba ndi mkaka wa m`mawere, chifukwa chosowa deta pa zamankhwala ntchito mankhwala panthawiyi.

- ana ndi achinyamata osakwana zaka 18, chifukwa chosowa deta pakachipatala.

Zochita zamankhwala osokoneza bongo

Imawonjezera mphamvu ya ma coronary dilating agents, mankhwala ena a antihypertensive, mtima glycosides.

Itha kuphatikizidwa ndi antianginal mankhwala, anticoagulants, antiplatelet agents, antiarrhythmic mankhwala, okodzetsa, bronchodilators.

Meldonium imatha kukulitsa mphamvu ya mankhwala okhala ndi glyceryl trinitrate, nifedipine, beta-blockers, mankhwala ena a antihypertensive, ndi zotumphukira vasodilators.

Odwala omwe ali ndi vuto la mtima omwe atenga meldonium ndi lisinopril nthawi yomweyo, zotsatira zabwino za kuphatikiza mankhwala zinaululidwa (kusintha kwa mitsempha yayikulu, kusintha kwa kufalikira kwa paripheral ndi moyo, kuchepetsa kupsinjika kwa malingaliro ndi thupi).

Pogwiritsa ntchito meldonium kuphatikiza ndi orotic acid kuti muchepetse zowonongeka zomwe zimayambitsidwa ndi ischemia / reperfusion, zotsatira zowonjezera zamankhwala zimawonedwa.

Chifukwa chogwiritsa ntchito munthawi yomweyo Sorbifer ndi meldonium odwala omwe ali ndi vuto la kuchepa kwa mchere wachitsulo, kapangidwe kazinthu zamafuta m'magazi ofiira a magazi adayamba kuyenda bwino.

Meldonium imathandizira kuthetsa kusintha kwa mtima mu mtima komwe kumachitika chifukwa cha azidothymidine (AZT), ndipo kumakhudza mosiyanasiyana zochita za oxidative zomwe zimachitika chifukwa cha AZT, zomwe zimayambitsa kusokonekera kwa mitochondrial. Kugwiritsa ntchito kwa meldonium kuphatikiza AZT kapena mankhwala ena othandizira matenda omwe apezeka immunodeficiency syndrome (AIDS) kumathandizanso kuchiritsa kwa Edzi.

Mu mayeso a kutaya kwa ethanol Reflex, meldonium idachepetsa nthawi yogona. Pa kukhumudwa chifukwa cha pentylenetetrazole, kutanthauzira kwa anticonvulsant of meldonium kunakhazikitsidwa. Nawonso, pamene í-adrenoblocker yohimbine ali ndi 2 mg / kg ndi N- (G) -nitro-L-arginine synthase inhibitor pa mlingo wa 10 mg / kg amagwiritsidwa ntchito musanachitike mankhwala ndi meldonium, mphamvu ya antelonvulsant ya meldonium .

Mankhwala osokoneza bongo a meldonium amatha kukulitsa vuto la mtima chifukwa cha cyclophosphamide.

Kuchepa kwa carnitine chifukwa chogwiritsa ntchito D-carnitine (a pharmacological inomer isomer) -meldonium imatha kukulitsa mtima ndi mtima chifukwa cha ifosfamide.

Meldonium imateteza pakatikati pa mtima ndi chifukwa cha mtima wa neurinaxicity chifukwa cha efavirenz.

Chifukwa cha kuthekera kwa tachycardia wolimbitsa thupi komanso ochepa hypotension, kusamala kuyenera kuchitidwa pophatikizidwa ndi mankhwala omwe ali ndi vuto lofananalo, kuphatikizapo mankhwala ena okhala ndi meldonium.

Malangizo apadera

Pogwiritsa ntchito mankhwalawa kwanthawi yayitali, odwala omwe ali ndi matenda osachiritsika a chiwindi ndi / kapena impso ayenera kusamala (chiwindi ndi / kapena kuwunika ntchito kwa impso kuyenera kuchitidwa).

Meldonium si mankhwala a mzere woyamba wa matenda oopsa a coronary.

Zomwe zimachitika chifukwa cha mankhwalawa amatha kuyendetsa galimoto kapena njira zoopsa

Musamale muyenera kuyendetsa galimoto mukamayendetsa galimoto kapena pamakina oopsa.

Bongo

Milandu ya bongo ndi meldonium osadziwika, mankhwalawa ndi oopsa.

Ndi kuthamanga kwa magazi, kupweteka mutu, chizungulire, tachycardia, ndi kufooka wamba ndikotheka.

Pankhani ya bongo wambiri, ndikofunikira kuwongolera ntchito ya chiwindi ndi impso.

Chifukwa chomangiriza mankhwalawo kumapuloteni, hemodialysis siyofunika.

Wopanga

JSC "Grindeks", Latvia

Adilesi ya bungwe lomwe lachititsa gawoloRepublic of Kazakhstan akuti kuchokera kwa ogula pamtundu wazogulitsa

Kuyimira kwa JSC "Grindeks"

050010, Almaty, Dostyk Ave., ngodya ya ul. Bogenbai Batyr, d. 34a / 87a, ofesi No. 1

Mankhwala

Meldonium (MILDRONAT ®) ndi analogue ya gamma-butyrobetaine - chinthu chomwe chimapezeka mu khungu lililonse la thupi la munthu.

Pazinthu zowonjezereka, MILDRONAT ® imabwezeretsa kuchuluka pakati pa kubereka ndi kuchepa kwa mpweya m'maselo, kumachepetsa kudziunjikira kwa zinthu za poizoni zama cell mu cell, kuziteteza kuti zisawonongeke, komanso kukhala ndi mphamvu. Chifukwa chakugwiritsa ntchito, thupi limatha kulimbana ndi katunduyo ndikuwabwezeretsanso mphamvu zamagetsi.

Chifukwa cha malo awa, mankhwalawa MILDRONAT ® amagwiritsidwa ntchito pochiza matenda osiyanasiyana a CVS, magazi kupita ku ubongo, komanso kuwonjezera kuyendetsa thupi. Zotsatira zakuchepa kwa ndende ya carnitine, gamma-butyrobetaine yokhala ndi masodilating amapangidwe kwambiri. Ngati kuwonongeka kwa pachimake kwa ischemic kwa myocardium, mankhwalawa MILDRONAT ® amachepetsa mapangidwe a necrotic zone ndikufupikitsa nthawi yokonzanso. Ndi kulephera kwa mtima, kumawonjezera kuchepa kwa mtima, kumathandizira kulolerana, komanso kumachepetsa pafupipafupi matenda a angina. Mu pachimake komanso chovuta cha ischemic matenda amitsempha yamagazi, mankhwalawa MILDRONAT ® amathandizira kutsika kwa magazi poyang'ana ischemia, amalimbikitsa kugawa magazi mokomera dera la ischemic. Mankhwala amachotsa magwiridwe antchito a mitsempha mwa odwala omwe ali ndi uchidakwa woperewera.

Zisonyezero za mankhwala MILDRONAT ®

zovuta mankhwala a matenda a mtima (angina pectoris, myocardial infarction),

aakulu mtima kulephera ndi cardiomyopathy pa maziko a zovutaormoni

zovuta mankhwala a matenda pachimake ndi matenda a magazi kupita ku ubongo (sitiroko ndi cerebrovascular insufficiency),

hemophthalmus ndi retinal hemorrhages a etiologies ambiri, thrombosis ya chapakati retine mtsempha ndi nthambi zake, retinopathy yosiyanasiyana etiologies (matenda ashuga, hypertonic),

zochulukitsa m'maganizo ndi mwakuthupi (kuphatikiza othamanga) (mankhwalawa atha kupereka zotsatira zabwino pakuwongolera kuwongolera (onani. malangizo apadera),

kusiya achire matenda osokoneza bongo (kuphatikiza ndi enieni mankhwala a uchidakwa).

Mimba komanso kuyamwa

Chitetezo chogwiritsidwa ntchito mwa amayi apakati sichinaphunziridwe, chifukwa chake ntchitoyo imalepheretsedwa kuti mwana asabadwe.

Kupatula kwa mankhwala MILDRONAT ® ndi mkaka ndi momwe thanzi la mwana wakhanda silinaphunziridwe, chifukwa chake ngati kuli koyenera, kuyamwitsa kuyenera kuyimitsidwa.

Kuchita

Itha kuphatikizidwa ndi antianginal mankhwala, anticoagulants, antiplatelet agents, antiarrhythmic mankhwala, okodzetsa, bronchodilators.

Imawonjezera ntchito yamtima glycosides.

Chifukwa cha kukula kwa tachycardia komanso zolimbitsa thupi, muyenera kusamala mukaphatikizidwa ndi nitroglycerin, nifedipine, alpha-blockers, mankhwala ena a antihypertensive ndi vasodilators otumphukira, monga MILDRONAT ® imawonjezera zotsatira zawo.

Kutulutsa Fomu

Njira yothetsera makonzedwe amkati, mtsempha wamitsempha ndi parabulbar, 100 mg / ml. 5 ml pakanema kopanda galasi lopanda utoto wa hydrolytic kalasi ine ndi mzere kapena malo osweka.

5 amp iliyonse. mumalongedzo am'nyumba opangidwa ndi filimu ya PVC kapena filimu ya PET (pallet) yopanda mafuta. Pa 2 kapena 4 (okhawo omwe amapanga ZAO Santonika ndi HSBC Pharma sro) ma CD ama CD (ma pallets) mu paketi ya makatoni.