Vasotens® (Vasotens®)

Enieniotensin II wolandila wapadera (subtype AT1)
Kukonzekera: VAZOTENZ ®

The yogwira mankhwala: losartan
ATX Encoding: C09CA01
KFG: Angiotensin II receptor antagonist
Nambala yolembetsa: LS-002340
Tsiku lolembetsa: 12/08/06
Mwini reg. acc: ACTAVIS hf.

Fomu yotulutsa Vazotens, ma CD ndikuphatikizira ndi mankhwala.

Mapiritsi oyera ovomerezeka ndi ozungulira, biconvex, olembedwa "3L" mbali imodzi, omwe ali ndi zoopsa mbali zonse ziwiri ndi mbali ziwiri. 1 tabu losartan potaziyamu 50 mg
Omwe amathandizira: mannitol, microcrystalline cellulose, croscarmellose sodium, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 ma PC - matuza (2) - mapaketi a makatoni.
Mapiritsi oyera ovala ndi ovunda, biconvex, omwe amatchedwa "4L" mbali imodzi. 1 tabu losartan potaziyamu 100 mg
Omwe amathandizira: mannitol, microcrystalline cellulose, croscarmellose sodium, povidone K-30, magnesium stearate, hypromellose 6, titanium dioxide (E171), talc, propylene glycol.
7 ma PC - matuza (2) - mapaketi a makatoni.

Kufotokozera kwa mankhwalawa kumatengera malangizo ovomerezeka omwe angagwiritsidwe ntchito.

Kupanga ndi mawonekedwe a kumasulidwa

mu chithuza chamtundu 7 ma PC., mu paketi yamatabwa 2 matuza.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi okhala ndi mbali:

• 12,5 mg: chozungulira, chozungulira mbali zonse, zoyera, zolembedwa "1L" mbali imodzi,
• 25 mg: mozungulira, chozungulira mbali zonse, zoyera, zolembedwa "2L" mbali imodzi,
• 50 mg: yozungulira, yozungulira mbali zonse, yoyera, yokhala ndi zoopsa m'mbali zonse ziwiri, yokhala ndi "3" ndi "L" mbali zonse zowopsa,
• 100 mg: chowunga, chozungulira mbali zonse, choyera, chopanda mbali imodzi ndi "4L" cholozera mbali inayo, ndimavuto oyamba.

Kuyika mapiritsi: 7 ma PC. mu paketi yazovala, pamatoni okhala ndi matuza 2 kapena 4, ma PC 10. mu paketi yokhala ndi matuza, m'matayala okhala ndi matuza 1 kapena 3, ma PC 14. mu chithuza, pakatundu konyamula matuza 1 kapena 2. Paketi iliyonse ilinso ndi malangizo ogwiritsira ntchito vazotenza.

Chithandizo chogwira ntchito: losartan potaziyamu, piritsi limodzi - 12,5 mg, 25 mg, 50 mg kapena 100 mg.

Zothandiza: microcrystalline cellulose, hypromellose 6, povidone K-30, croscarmellose sodium, mannitol, magnesium stearate, propylene glycol, talc, titanium dioxide (E171).

Kufotokozera za mtundu wa kipimo

50 mg mapiritsi: mapiritsi a biconvex ozungulira, oyera, oyera, okhala ndi mbali imodzi "3L", okhala ndi zoopsa kumbali zonse ziwiri ndi m'mbali.

Mapiritsi a 100 mg: mapiritsi a ovic biconvex, oyera, okutira, ndi mawonekedwe mbali imodzi "4L".

Mankhwala

Losartan ndi wotsutsa winawake wa angiotensin II receptors, ndi wa gulu laling'ono la AT₁. Kinase II (puloteni yoipa ya bradykinin) siyimalephera.

Zotsatira zazikulu za losartan:

• kuchepa kwathunthu kwamitsempha yamagazi kukana, kuchuluka kwa aldosterone ndi adrenaline m'magazi, kuthamanga kwa magazi, kuthamanga kwa kufalikira kwa m'mapapo,
• pambuyo kuchepetsa
• diuretic kwenikweni
• kuteteza chitukuko cha myocardial hypertrophy,
• kuchuluka kulolerana pakati kulephera mtima.

Vasotens amakhala ndi vuto lotsogolera pambuyo pa mlingo umodzi (kuwonetsedwa ngati kuchepa kwa systolic ndi diastolic pressure), mpaka kufika patatha maola 6, ndiye kuti zotsatira zake zimachepera maola 24.

Pazinthu zapamwamba kwambiri za vasotenza zimayamba masabata 3-6 pambuyo poyambira kutsata.

Pharmacokinetics

Losartan imatengeka mwachangu kuchokera ku m'mimba. Bioavailability pafupifupi 33%. T_max (nthawi yoti ifike pazinthu zambiri) - 60 Mphindi.

Losartan amakumana ndi gawo loyambira kudzera pachiwindi, kagayidwe kamachitika ndi carboxylation ndi gawo la CYP2C9 isoenzyme, ndipo metabolite yogwira imapangidwa. T_max yogwira metabolite - maola 3-4, momwe amamangirira mapuloteni am'madzi - 99%.

T_1/2 (theka-moyo) la chinthu lili m'gulu kuyambira 1.5 mpaka maola 2, metabolite yake yayikulu ndi maola 8-9. Pafupifupi 35% ya mankhwalawa amamuchotsa mkodzo, m'matumbo - pafupifupi 60%.

Ndi cirrhosis ya chiwindi, kuchuluka kwa plasma kwa losartan kumawonjezeka kwambiri.

Vazotens, malangizo ogwiritsira ntchito: njira ndi mlingo

Mapiritsi a Vazotens amayenera kumwedwa pakamwa kamodzi pa tsiku (mosasamala kuchuluka kwa mankhwala). Nthawi ya chakudya ilibe kanthu.

Mlingo wofanana wa vasotenza:

• ochepa matenda oopsa: ambiri achire mlingo ndi 50 mg, kuti akwaniritse kwambiri, nkotheka kuwonjezera mlingo mpaka 100 mg, ngati kuli kotheka, mlingo wa tsiku ndi tsiku utha kugawidwa mu 2 waukulu. Mlingo woyamba wa odwala omwe alandira kuchuluka kwa okodzetsa ndi 25 mg.
• kulephera kwa mtima: mlingo woyamba ndi 12,5 mg, ndiye umachulukitsidwa pakadutsa sabata limodzi, woyamba mpaka 25 mg, kenako mpaka 50 mg. Mlingo wapakati wokonza ndi 50 mg.

Pa mlingo wotsika, vasotens amalembedwa kwa odwala omwe ali ndi vuto la chiwindi, kuphatikizapo matenda enaake.

Zotsatira zoyipa

Nthawi zambiri, ma vasotens amaloledwa bwino, kusintha kosiyanasiyana kumakhala kwakanthawi ndipo sikufuna kuchotsedwa kwa mankhwala.

Zotsatira zoyipa:

• Kuchokera pamtima dongosolo: orthostatic hypotension (amadalira mlingo), palpitations, arrhythmias, bradycardia, tachycardia, angina pectoris,
• Kuchokera kwamankhwala amanjenje: Nthawi zambiri (≥ 1%) - chizungulire, kutopa, asthenia, kusowa tulo, kupweteka mutu, kawirikawiri (

Mimba komanso kuyamwa

Palibe deta yogwiritsa ntchito losartan panthawi yapakati. Komabe, zimadziwika kuti mankhwalawa omwe amakhudza mwachindunji dongosolo la renin-angiotensin, akapezeka munthawi yachiwiri ndi yachitatu ya amayi omwe ali ndi pakati, amatha kuyambitsa chitukuko kapena ngakhale kufa kwa mwana wosabadwayo. Chifukwa chake, ngati kutenga pakati kumachitika, Vazotenza ® iyenera kusiyidwa pomwepo.

Mukamayikidwa pa mkaka wa m`mawere, lingaliro liyenera kuperekedwa kuti liyime kuyamwitsa kapena kusiya kumwa mankhwala ndi Vazotens ®.

Kuchita

Zitha kutumikiridwa ndi othandizira ena othandizira.

Palibe kuyanjana kwakukulu ndi hydrochlorothiazide, digoxin, anticoagulants, cimetidine, phenobarbital.

Odwala omwe ali ndi vuto losowa madzi m'thupi (mankhwala asanafike pakukodzetsa kwakukulu), kuchepa kwakukulu kwa magazi kungachitike.

Zowonjezera (kutulutsa) zotsatira zamankhwala ena a antihypertensive (okodzetsa, obeta-blockers, sympatholytics).

Amawonjezera chiopsezo cha hyperkalemia akagwiritsidwa ntchito limodzi ndi potaziyamu-pofinya okodzetsa ndi potaziyamu.

Mlingo ndi makonzedwe

Mkati ngakhale chakudyacho. Kuchulukitsa kuvomerezeka - 1 nthawi patsiku.

Ndi ochepa matenda oopsa, pafupifupi tsiku lililonse 50 mg. Nthawi zina, kuti mukwaniritse kwambiri, mlingo umakulitsidwa mpaka 100 mg mu 2 Mlingo kapena nthawi 1 patsiku.

Mlingo woyamba wa odwala omwe ali ndi vuto la mtima ndi 12,5 mg kamodzi patsiku. Monga lamulo, mlingo umakulitsidwa ndi gawo la sabata (i.e. 12.5, 25 ndi 50 mg / tsiku) pamlingo wabwino wokonza 50 mg kamodzi patsiku, kutengera kulekerera kwa wodwala kwa mankhwalawo.

Popereka mankhwala kwa odwala omwe amalandira okodzetsa kwambiri, muyezo wa mankhwalawa Vazotens ® uyenera kuchepetsedwa mpaka 25 mg kamodzi patsiku.

Odwala omwe ali ndi vuto la chiwindi ntchito ayenera kupatsidwa mlingo waukulu wa Vazotenza ®.

Odwala okalamba, komanso odwala omwe ali ndi vuto laimpso, kuphatikizanso odwala omwe ali ndi dialysis, palibe chifukwa chosinthira koyamba mlingo.

Kugwiritsa ntchito kwa ana

Chitetezo ndi kufunika kwa mankhwalawa kwa ana sichinakhazikitsidwe.

Malangizo apadera

Ndikofunikira kukonza kuchepa kwam'madzi musanapange mankhwala a Vazotens ® kapena kuyamba kulandira mankhwala pogwiritsa ntchito mankhwalawa.

Mankhwala omwe amakhudzana ndi renin-angiotensin amatha kuwonjezera urea ndi serum creatinine mwa odwala omwe ali ndi vuto la impso.

Panthawi ya chithandizo, kuchuluka kwa potaziyamu m'magazi kuyenera kuyang'aniridwa pafupipafupi, makamaka odwala okalamba, omwe ali ndi vuto laimpso.

Alumali moyo wa mankhwala Vazotens ®

mapiritsi okhala ndi tulo 12,5 mg - 3 zaka.

mapiritsi okhala ndi tulo 12,5 mg - 3 zaka.

TACHIMATA mapiritsi 25 mg - 3 zaka.

TACHIMATA mapiritsi 25 mg - 3 zaka.

TACHIMATA mapiritsi 50 mg - 3 zaka.

TACHIMATA mapiritsi 50 mg - 3 zaka.

TACHIMATA mapiritsi 100 mg - 3 zaka.

TACHIMATA mapiritsi 100 mg - 3 zaka.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Pharmacological zochita za vasotens

Enieniotensin II wolandila wapadera (subtype AT1). Amalepheretsa kinase II, enzyme yomwe imaphwanya bradykinin. Amachepetsa OPSS, kuchuluka kwa magazi a adrenaline ndi aldosterone, kuthamanga kwa magazi, kuthamanga mu kufalikira kwa mapapu. Amachepetsa pambuyo, ali ndi okodzetsa. Zimalepheretsa kukula kwa myocardial hypertrophy, kumawonjezera kulolerana kwa odwala omwe ali ndi vuto la mtima.
Pambuyo pa limodzi mlingo, mphamvu ya hypotensive (systolic ndi diastolic magazi imatsika) imafika pazowonjezera pambuyo pa maola 6, kenako imayamba kuchepa mkati mwa maola 24.
Kwambiri hypotensive zotsatira zimatheka masabata 3-6 pambuyo pa kuyamba kwa mankhwalawa.

Ma Vazotens: mitengo yamafesi apamtaneti

Vazotens 12,5 mg phukusi mapiritsi 30 ma PC.

Vazotens 50 mg wophatikizira mafilimu 30 ma PC.

VAZOTENZ 50mg 30 ma PC. mapiritsi okutira

Vazotens tabu. PO 50mg n30

Vazotens tabu. PO 100mg n30

Vazotens 100 mg wophatikizira mafilimu 30 ma PC.

VAZOTENZ 100mg 30 ma PC. mapiritsi okutira

VAZOTENZ N 100mg + 25mg 30 ma PC. mapiritsi okhala ndi filimu

Maphunziro: Rostov State Medical University, apadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo ovomerezeka. Kudzipatsa nokha mankhwala kuopsa!

Kuti tinene ngakhale mawu afupi komanso osavuta, timagwiritsa ntchito minofu 72.

Anthu omwe amakonda kudya chakudya cham'mawa nthawi zambiri amakhala onenepa kwambiri.

Munthu wophunzira sakhala wokonzeka kutenga matenda aubongo. Ntchito zaluso zimathandizira kuti pakhale ziwalo zina zowonjezera kulipirira odwala.

Madokotala a mano adapezeka posachedwa. Kalelo m'zaka za zana la 19, inali ntchito ya tsitsi wamba kuti akatulutse mano odwala.

Chiwindi chanu chikasiya kugwira ntchito, imfa imatha pakatha tsiku limodzi.

Malinga ndi asayansi ambiri, mavitamini zovuta ndizothandiza kwa anthu.

Pa moyo, munthu wamba amapanga miyala yocheperako yoposa awiri.

Malinga ndi ziwerengero, Lolemba, chiopsezo cha kuvulala kwammbuyo chimawonjezeka ndi 25%, ndipo chiopsezo chogundidwa ndi mtima - ndi 33%. Samalani.

Malinga ndi kafukufuku wa WHO, kuyankhulana kwa theka la ola limodzi pafoni kumawonjezera mwayi wokhala ndi chotupa muubongo ndi 40%.

Ngati mumamwetulira kawiri kokha patsiku, mutha kuchepetsa kuthamanga kwa magazi ndikuchepetsa chiopsezo cha matenda a mtima ndi stroko.

Nthawi yayitali yotsala ndiyotsika ndi yoyipa.

Pali ma syndromes osangalatsa kwambiri azachipatala, monga kuphatikiza zinthu. M'mimba mwa wodwala m'modzi wodwala mania uyu, zinthu 2500 zakunja zidapezeka.

Magawo anayi a chokoleti chakuda ali ndi zopatsa mphamvu pafupifupi mazana awiri. Chifukwa chake ngati simukufuna kukhala bwino, ndibwino kuti musadye zopitilira awiri patsiku.

Ntchito yomwe munthu samakonda imakhala yovulaza psyche yake kuposa kusowa kwa ntchito konse.

Mafupa aanthu ndi olimba kwambiri kuposa konkriti.

Mphepo yoyamba ya maluwa ikufika kumapeto, koma mitengo yamaluwa idzasinthidwa ndi udzu kuyambira koyambirira kwa Juni, zomwe zimasokoneza omwe ali ndi vuto lodziwika bwino.

Mlingo ndi njira ya mankhwala.

Mankhwala amatengedwa pakamwa, ngakhale chakudya, pafupipafupi makonzedwe - 1 nthawi / tsiku.
Ndi ochepa matenda oopsa, pafupifupi tsiku lililonse 50 mg. Nthawi zina, kuti mukwaniritse kwambiri, mlingo umakulitsidwa mpaka 100 mg mu 2 Mlingo kapena 1 nthawi / tsiku.
Popereka mankhwala kwa odwala omwe amalandira okodzetsa kwambiri, muyezo wa mankhwalawa Vazotens uyenera kuchepetsedwa mpaka 25 mg 1 nthawi / tsiku.
Mlingo woyamba wa odwala omwe ali ndi vuto la mtima ndi 12,5 mg 1 nthawi / tsiku. Mwachizolowezi, mankhwalawa amawonjezeka ndi gawo la sabata (i.e. 12.5 mg / tsiku, 25 mg / tsiku ndi 50 mg / tsiku) pa avareji yokonza pafupifupi 50 mg 1 nthawi / tsiku, kutengera kulekerera kwa wodwala.
Odwala omwe ali ndi vuto la chiwindi ntchito (kuphatikiza ndi cirrhosis) ayenera kutsegulidwa Mlingo wapansi wa vasotenz.
Odwala okalamba, komanso odwala omwe ali ndi vuto laimpso, kuphatikiza odwala omwe ali ndi dialysis, palibe chifukwa chosinthira koyamba mlingo.