Onglisa - mapiritsi a shuga

Matendawa masiku ano amakhudza anthu 9% padziko lapansi. Makampani opanga mankhwala ndi machitidwe azachipatala a mayiko otsogola padziko lonse lapansi akuika ndalama mabiliyoni ambiri, ndipo matenda ashuga akuyenda mozungulira dziko lapansi, kuyamba kukhala achichepere, ndikukhalanso ankhanza.

Vutoli likufika pamlingo womwe sunkayembekezeredwa: podzafika 2020, theka la mabiliyoni odwala omwe ali ndi matenda a shuga a 2 akunenedweratu, ndipo madokotala sanaphunzire momwe angapewere matendawa moyenera.

Ngati ndi matenda amtundu wa 1 shuga, omwe amakhudza osakwana 10% ya onse odwala matenda ashuga, zonse ndizosavuta: muchepetse kuchuluka kwa shuga m'magazi mwa kubaya insulini (palibe chomwe chingaperekedwe pamenepo) ndipo zonse zikhala bwino (lero, kwa odwala oterowo, adayambitsa kapamba wochita kupanga) ), ndiye ndi matenda a shuga 2, ukadaulo wapamwamba sugwira ntchito.

Mwa fanizo la matenda a shuga a 2, shuga adadziwika kuti ndiye mdani wamkulu, kudzaza msika ndi mankhwala ochepetsa shuga. Mankhwala a odwala matenda ashuga mothandizidwa ndi mapiramidi othandizira amalimbikitsidwa, mankhwala ena akapaka mankhwala amodzi, ndiye kuti mankhwala ena achitatu amawonjezeredwa ku zovuta izi kufikira nthawi ya insulin itafika.

Kwa zaka 20 zapitazi, madokotala akhala akulimbana ndi shuga, koma zotsatira zake zimakhala zotsika, chifukwa zovuta komanso zovuta kuchokera ku mankhwala nthawi zambiri zimapambana, makamaka ngati simumatsatira mlingo, musaganizire kuti mankhwalawo ndiabwino komanso ndani osachita.

Chimodzi mwa ziwalo zomwe tikufuna ndi mtima ndi mtsempha wamagazi. Zimatsimikiziridwa kuti chithandizo chachikulu cha matenda ashuga chimayambitsa zosiyana ndipo zimapangitsa kufa kwa mitsempha. Shuga ndi chizindikiro chabe cha matenda amtundu wa 2; matendawa amatengera metabolic syndrome.

Mankhwala a m'badwo watsopano Onglisa, opangidwa ndi asayansi aku Britain ndi ku Italy, sikuti amangothandiza odwala, komanso luso la mtima. Mankhwala a mndandanda wa maretretin, omwe akuphatikizapo Onglisa, ndi zomwe zapezeka pamunda wa matenda ashuga. Amagwira ntchito kuti achepetse kusadya komanso kuwonda - chimodzi mwazifukwa zazikuluzakhazikitsira matenda a shuga 2.

Kuphatikiza apo, incretinomimetics silipiritsa hypoglycemia, amathandizira kuchepetsa kuthamanga kwa magazi, komanso kuteteza maselo a pancreatic. Mtengo wokwera komanso kusowa kwa chithandizo chachipatala chifukwa chakugwiritsa ntchito mankhwalawa kungachitike chifukwa cha zovuta za Onglisa, koma izi ndizofunikanso nthawi.

Kupanga ndi mawonekedwe a kumasulidwa

Piritsi iliyonse ya Onglisa, chithunzi chake chomwe chaperekedwa m'gawoli, chili ndi 2.5 kapena 5 mg ya saxagliptin hydrochloride mu chipolopolo. Fomuloli idathandizidwa ndi ma excipients: cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate ndi Opadray utoto (woyera, wachikasu ndi wabuluu mapiritsi a 2.5 mg ndi oyera, apinki ndi abuluu pamtundu wa 5 mg).

Mankhwalawa amatha kuzindikiridwa ndi mawonekedwe (mapiritsi a biconvex okhala ndi chikasu chachikasu ndikuwonetsa 2,5 / 4214 ndi pinki wolemba 5/4215). Zolemba zake zimasindikizidwa mbali iliyonse ndi inki wabuluu.

Mutha kugula mankhwala omwe mumalandira. Kwa mapiritsi a Ongliz, mtengo wake suchokera pagulu la bajeti: 30 ma PC. 5 mg ku Moscow muyenera kulipira ma ruble 1700. Wopanga adatsimikiza moyo wamashelefu pazaka zitatu. Malo osungira mankhwalawa ndi muyezo.

Zotsatira za pharmacological

Chofunikira chachikulu cha Onglisa ndi saxagliptin. Pasanathe tsiku limodzi atalowa m'mimba, zimalepheretsa ntchito ya DPP-4 peptide. Mukakumana ndi glucose, kuponderezedwa kwa enzyme modabwitsa (katatu) kumathandizira kubisalira kwa glucagon-ngati peptide-1 (GLP-1) ndi glucose-wodalira insulinotropic polypeptide (HIP).

Nthawi yomweyo, kuchuluka kwa glucagon mu b-cell kumachepa, ntchito ya ma b-cell omwe amachititsa kuti ma cell a insulin achuluke. Zotsatira zake, zizindikiro za kusala ndi postprandial glycemia zimachepetsedwa kwambiri.

Chitetezo ndikuyenda bwino kwa mankhwalawa adaphunziridwa poyesa 6, momwe amodzi odzipereka a 4148 omwe adatenga nawo matenda a 2 adagwira nawo. Onse ogwira nawo ntchito adawonetsa kusintha kwa glycated hemoglobin, shuga yokhala ndi njala ndi glycemia pambuyo ponyamula katundu. Mankhwala owonjezera, monga thiazolidinediones, metformin, glibenclamide, adawerengedwa kwa omwe atenga nawo gawo omwe sanakwaniritse 100% glycemic control.

Odwala omwe ali ndi mankhwala owonjezera a antiidiabetes amawonetsa zotsatira zofananazo. Kulemera kwa onse omwe atenga nawo mayesowa kunakhazikika.

Saxagliptin akapatsidwa

Anthu odwala matenda ashuga a mtundu 2

1. Monga monotherapy, kuphatikiza kusintha kwamachitidwe,
2. Kuphatikiza, ndikuphatikiza kwa njira yapita ndi metformin, ngati monotherapy sichimapereka chiwongolero chonse cha glycemia,
3. Pamodzi ndi zotumphukira za mndandanda wa sulfanylurea ndi thiazolidinediones, ngati kuphatikiza kwapapitako sikunakhale kokwanira.

Kwa Onglisa wapangika

Popeza saxagliptin ndi chothandizira champhamvu chomwe chimapangitsa ntchito ya maselo a B ndikulephera kugwira ntchito kwa maselo a b, chitha kugwiritsidwa ntchito ndi malire, makamaka, mankhwalawa sanasonyezedwe:

• Amayi oyembekezera komanso oyembekezera
• Muubwana,
• Anthu odwala matenda ashuga a mtundu woyamba,
• Ndi mtundu wa 2 wodwala insulin,
• Matenda a shuga ketoacidosis
• Ngati wodwala salola galactose,
• Ndi hypersensitivity pazomwe zimapangidwira.

Mukamasankha mtundu wa mankhwala, dokotala samangoyang'ana pa zomwe zaphatikizidwa, komanso mawonekedwe a saxagliptin a mankhwalawa omwe wodwala matenda ashuga amatenga ku matenda oyanjana. Chifukwa chake, mankhwala onse omwe munthu wodwala matenda ashuga amawagwiritsa ntchito limodzi, dokotala amayenera kudziwitsidwa munthawi yake.

Malangizo ogwiritsira ntchito

Dokotalayo ndi amene amawerengera kuchuluka kwa mankhwalawo payekhapayekha, poganizira zotsatira za mayeso, zaka, magawo a matendawo, momwe thupi limayendera. Kwa Onglisa, malangizo ogwiritsira ntchito amalimbikitsa kumwa mapiritsiwo pakamwa, osamangidwa nthawi yakudya. Muyeso woyamba wa mankhwalawa ndi 5 mg / tsiku.

Kumayambiriro kwa chithandizo, chiwembu chokhazikika chikuwoneka motere:

1. Saksagliptin - 5 mg / tsiku.,
2. Metformin - 500 mg / tsiku.

Pambuyo masiku 10-15, onetsetsani momwe mankhwalawo adasinthira ndipo ngati kuli kotheka, sinthani mlingo wa metformin, sungani mulingo wa Onglisa osasinthika.

Ngati nthawi yakumwa mankhwalawo ikusowa, imamwa mankhwalawo nthawi yoyamba. Simungathe kuchita zofananira, chifukwa thupi limafunikira nthawi kuti lizisinthe.

Ngati pali mbiri yodwala matenda a impso, ndiye kuti palibe chifukwa chodalira. Ndi mawonekedwe olimbitsa komanso okhwima, chizolowezi chimachepetsedwa nthawi 2 - 2,5 mg / tsiku. (nthawi imodzi).

Pa hemodialysis, piritsi imatha kumwa pamapeto a njirayi. Zotsatira za Onglisa kwa odwala omwe ali ndi ziwalo zam'mimba za m'mimba sizinaphunzire. Musanapereke mankhwala komanso nthawi yonseyi, ndikofunikira kuwunika momwe impso zimayendera.

Ndi hepatic pathologies, mankhwalawa amatchulidwa muyezo mlingo wa 5 mg / tsiku. Kwa odwala matenda ashuga okalamba, kumwa mankhwala sikofunikira, koma vuto la impso liyenera kuganiziridwanso.

Mlingo wa ma insretins umachepetsedwa ndi theka ndi zovuta mankhwala okhala ndi zoletsa:

• Atazanavir
• Ketoconazole,
• Igraconazole
• Nelfinavir
• Clarithromycin
• Ritonavir
• Saquinavir,
• Indinavir
• Telithromycin.

Palibe chidziwitso chakuvomerezeka pakugwiritsa ntchito mankhwalawa kwa amayi apakati ndi ana osakwana zaka 18, chifukwa chake, ma fanizo amasankhidwa m'gulu la odwala matenda ashuga.

Zosafunika zotsatira ndi mankhwala osokoneza bongo

Mankhwala a gulu lamagulu ampretin am'badwo waposachedwa kwambiri. Ndi malingaliro onse adotolo, Ongliz amaloledwa nthawi zambiri ndi ambiri odwala matenda ashuga.

Nthawi zina, zotsatirazi zalembedwa:

• Matenda a Dyspeptic
• Mutu
• Pancreatitis
• Matenda opatsirana
• Matenda a urogenital a matenda opatsirana.

Ngati chimodzi mwazizindikirozi kapena kusokonezeka kwina kwina kukuchitika, muyenera kuyimitsa kugwiritsa ntchito mankhwalawa ndikuwonana ndi dokotala.

Pazifukwa zasayansi, mankhwalawo adaperekedwa kwa odzipereka mu Mlingo wopitilira muyeso ka 80. Zizindikiro za kuledzera sizokhazikika. Saxagliptin yowonjezera imatha kuchotsedwa pogwiritsa ntchito hemodialysis.

Malangizo owonjezera

Saxagliptin sanalembedwe mndandanda wapatatu momwe ma jakisoni a insulin amaphatikizidwira ndi metformin ndi thiazolidinediones, popeza zotsatira za kuyanjanazi sizinaphunzire. Kuwongolera impso kumachitika pa magawo onse a chithandizo ndi Onglisa, koma ndi mawonekedwe ofatsa, mlingo wake sasinthidwa, nthawi zina amachepetsa.

Saxagliptin pokhudzana ndi zotsatira za hypoglycemic ndiotetezeka konsekonse, koma kuphatikiza ndi mankhwala a sulfonylurea kumatha kupangitsa zochitika za hypoglycemic. Chifukwa chake, ndi zovuta chithandizo, titration wa chomaliza m'njira yochepetsera ndizovomerezeka.

Pankhani ya tsankho la mankhwalawa opatsirana - DPP-4 zoletsa, Onglisa sakusungidwanso, popeza nthawi zina thupi limasokonekera kuyambira pakhungu loyipa mpaka kugunda kwa anaphylactic ndi angioedema, likufuna kuchotsedwa kwa mankhwala mwachangu.

Popeza mankhwalawa ali ndi lactose, sikuti amaperekedwa kwa odwala matenda ashuga omwe amalephera kutulutsa, kuperewera kwa lactose, shuga-galactose malabsorption.

Panthawi yowunika odwala matenda ashuga atatha kulandira chithandizo ndi Onglisa, panali zochitika zina za chitukuko cha kapamba. Popereka mankhwala a saxagliptin, wodwalayo ayenera kudziwitsidwa za chizindikiro: kupweteka kosalekeza komanso koopsa kwa epigastrium.

Ngati m'mimba mulibe vuto, muyenera kusiya kumwa mankhwalawo ndikuwuza adotolo. Zotsatira zake zimakhala zosakhalitsa komanso zosinthika, zimangopita kwa iwo atasiya kumwa mankhwalawo.

Mu aimpso kukanika modekha ndi wowonda mawonekedwe, limodzi mlingo kusanza. M'mavuto akulu, Onglizu amagwiritsidwa ntchito mosamala, panthawi yodwala, pomwe wodwala sangathe popanda hemodialysis, osagwiritsa ntchito konse. Kuwunika momwe impso zimakhalira kumachitika musanayambe maphunziro anu ndipo miyezi isanu ndi umodzi iliyonse yogwiritsidwa ntchito ndi Ogliza.

Zochitika pochiza odwala matenda ashuga okalamba (kuyambira zaka 75) sizokwanira, chifukwa chake, gulu ili la odwala limafunikira chidwi chachikulu.

Zotsatira za kuthekera kwa Onglisa pakuwongolera mayendedwe kapena njira zovuta sizinafalitsidwe, chifukwa chake, odwala matenda ashuga ayenera kumwa mankhwalawa mosamala, makamaka chifukwa chizungulire chimachitika pakati pamavuto. Kuchita chidwi kwambiri ndi zoterezi zimafunika kwa odwala omwe amagwiritsa ntchito Onglisa mu chithandizo chovuta, chifukwa mankhwala ena othandizira amatha kudzetsa hypoglycemia.

Kugwiritsa ntchito mankhwalawa pamatenda amtima kumaonetsa kuti mankhwalawa amateteza kugunda kwa mtima. Ku America, ngakhale pamlingo wambiri wa shuga, adotolo amafotokozera odwala matenda ashuga ndi arrhythmia Onglizu kuti apititse patsogolo glycemic indices ndi kubwezeretsa kugunda kwa mtima.

Kuyanjana ndi Mankhwala ndi Onglisa ndi fanizo

Malinga ndi kuchuluka kwa kafukufuku wasayansi, zotsatira za kulumikizana kwa Onglisa ndi zinthu zina panthawi yovuta ya mankhwalawa sizofunikira.

Zotsatira zakuthandizidwe kwa mankhwalawa pakumwa mowa, ndudu, zakudya zingapo, mankhwala othandizira kunyumba sanakhazikitsidwe.

Mu mawonekedwe apiritsi, kuchokera pamndandanda wa ma incretin, pamodzi ndi Onglisa, Galvus ndi Januvia amamasulidwa, cholembera - Baetu ndi Viktoza.

Makina a akatswiri ndi ogwiritsa ntchito

Pamabwalo azokambirana za mankhwala Ongliza, ndemanga zake ndizabwino, mwina kungobweretsanso mtengo ndi zomwe zimafanana ndi ku Europe.

Tsoka ilo, matenda, monga ukalamba, sangasinthe komanso sangapewere chifukwa thanzi, monga mukudziwa, sizingagulidwe, ndipo mtundu wachiwiri wa matenda ashuga sudziwakuti mwangozi.

Koma kapamba amene ali ndi matenda ashuga omwe ali ndi mtundu wachiwiri sakhazikika, amakhala ndi malo obwezeretsanso ntchito zake, ndikuwathetsa ngati osagwira (kuchokera pamalingaliro a insulin secretion).

Asanamasule Ongliza kumsika, wopanga adagwiritsa ntchito mabiliyoni ambiri osati kungowonetsa kusakhala ndi zotsatirapo zoipa, komanso kutsimikizira momwe amagwirira ntchito. Ngati mankhwalawa angathandizire kuchedwetsa zovuta kwa zaka 10- 20, ngakhale nthawi yino yodzaza (popanda vuto la mtima, chibadwa, ziwopsezo, khungu, kusabala, kuperewera kwa impso), ndikofunika kuyang'anitsitsa.

Ndemanga za kuthekera kwa Onglisa ndi zotsatira za mankhwala a shuga pa thanzi la endocrinologist Shmul Levit, mutu. Institute of Diabetesology, onani vidiyo:

Zizindikiro zogwiritsidwa ntchito

Mtundu wachiwiri wa matenda ashuga, chiwopsezo cha maselo ku glucose amachepetsa kwambiri. Pakadali pano, pali kuchedwa mu gawo loyamba la kuphatikiza kwa mahomoni.

Mtsogolomo, gawo lachiwiri limatayika chifukwa chosowa ma insretin. Kuchepetsa kwa chiwonetsero cha enzyme DPP 4, ma insretin amakhala nthawi yayitali m'magazi, insulin yambiri imapangidwa. Glycemia pamimba yopanda kanthu komanso yodzaza imakonzedwa, kugwira ntchito kwa kapamba kumabwezeretsedwa. Chifukwa chake, Onglisa amawonjezera ntchito ya mahomoni awoawo, amawonjezera zomwe ali.

Mankhwala Onglisa okhala ndi matenda a shuga a 2 (kuwonjezera pa zakudya zoyenera ndi masewera) amasonyezedwa monga:

• mankhwala oyamba ndimankhwala angapo, limodzi ndi metformin,
• mankhwala othandizira ndi metformin, insulin, zotumphukira za sulfonylurea,
• monotherapy.

Kugwiritsa ntchito Onglises kumapangitsa kuti glycemic control.

Kutulutsa Fomu

Dziko loyambira - USA, koma mapiritsi okonzedwa okonzeka akhoza kuikidwa mu UK kapena Italy.

Amapangidwa mwanjira ya mapiritsi ozungulira, ma convex mbali zonse ziwiri, mbali yakunja ndi yokutira. Piritsi lililonse limakhala ndi manambala amtambo. Mtundu wa Onglisa umatengera kuchuluka kwa zinthu zomwe zimagwira: 2.5 mg iliyonse ndi maso achikasu achikasu ("2,5" amalembedwa mbali imodzi, "4214" amalembedwa mbali inayo), ndipo 5 mg iliyonse ndi yapinki (manambala “5” ndi “4215 ").

Mapiritsiwo amakhala m'matumba opangidwa ndi zojambulazo: m'matumba amodzi 3 matuza a zidutswa 10. Chodzaza chilichonse chimakhala ndi mafuta omwe amagawa magawo 10 (mwa kuchuluka kwa mapiritsi). Katemera wa makatoni amatetezedwa kuti asasokonekera ndi zomata zowoneka bwino zomwe zimawonetsa mauna achikasu.

Kuzindikira kwa shuga - ingomwani tsiku lililonse.

Mutha kugula mankhwala a shuga Onglizu m'masitolo ogulitsa. Mankhwala omwe akupezeka, koma si onse azachipatala omwe amatsatira lamuloli. Mu 2015, mankhwalawa adaphatikizidwa pamndandanda wazofunikira, kotero ngati wodwala matenda ashuga adalembetsa, akhoza kuupeza kwaulere.

Pafupipafupi, mtengo wokumangira mapiritsi 30 ndi pafupifupi 1800 rubles. Sungani mankhwalawo pa kutentha kosachepera 30 madigiri kutali ndi ana. Kusungirako sikuyenera kupitirira zaka zitatu.

Zomwe zimagwiritsidwa ntchito ndi saxagliptin hydrochloride (2,5 kapena 5 mg). Uwu ndi woyimira wa inhibitor wamakono wa DPP-4.

Othandizira ndi:

• MCC
• lactose monohydrate,
• sodium croscarmellose,
• magnesium wakuba,
• hydrochloric acid
• utoto.

Gawo lakunja la piritsi limakhala ndi utoto wa OpadryII.

Malangizo ogwiritsira ntchito

Mankhwala atayamba ndi Onglisa, wodwalayo ayenera kusintha zakudya zabwino komanso kuchita masewera olimbitsa thupi.Mankhwalawa amagwira ntchito mofatsa, chifukwa, pakalibe zakudya zoyenera komanso kuchita masewera olimbitsa thupi, samapereka chiphuphu choyenera cha glucose. Pazitali kwambiri pazogwira zomwe zimachitika pambuyo pa mphindi 150, mphamvu ya mankhwalawa imatha maola 24.

Ongliz amayenera kudyedwa mkati nthawi yokhayokha yopeza zakudya. Mlingo umodzi molingana ndi malangizo ndi 5 mg.

Ngati mankhwalawa aphatikizidwa kwa odwala matenda ashuga, Ongliza amagwiritsidwa ntchito molumikizana ndi metformin, sulfonylureas kapena thiazolidinediones.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Pa chithandizo choyambirira ndi metformin, mlingo umodzi koyambirira ndi 500 mg patsiku. Osatinso kuchitapo kanthu, mlingo umakulirakulira.

Wodwala akaphonya mlingo wotsatira wa mankhwalawo, phwando liyenera kuyambiranso mwachangu. Pankhaniyi, palibe chifukwa chowonjezera kuchuluka.

Akatswiri amalangiza pophatikiza mankhwala omwe ali ndi indinavir, ketoconazole ndi ena othandizira a CYP 3A4 / 5 zoletsa 2.5 mg patsiku.

Mlingowo umachepetsedwa kukhala 2,5 mg wa mankhwalawa akamathandizidwa ndi maantibayotiki ndi othandizira.

Zolemba zogwiritsira ntchito

Pa gawo loyamba la kusintha kwa impso, palibe chifukwa chosinthira. Pamavuto akulu kwambiri, hemodialysis, mlingo woyenera wa mankhwala a Ongliza ndi 2.5 mg patsiku. Mankhwalawa amalimbikitsidwa kuti aperekedwe njira yakuyeretsa magazi ikatha. Pamaso pathu ndi chithandizo, ndikofunikira kuwunika momwe impso zimayambira.

Zotsatira za Onglises pa thupi ndi njira yodziwira kuyeretsa magazi sizinafufuzidwe.

Kusintha kwa ntchito ya chiwindi, mosasamala za kuopsa, sikofunikira kusintha kamodzi.

Zotsatira zakugwiritsa ntchito kwa Onglisa mu odwala matenda ashuga oposa 65 ndizofanana ndi zomwe zimachitika kwa odwala achichepere. Mukakalamba, muyenera kumwa nthawi zonse. Ndikofunikira kukumbukira kuti pa nthawi iyi ya chitukuko, kugwira ntchito kwa impso kumachepa, gawo lomwe likugwira ntchito mokwanira linawatulukira.

Palibe chidziwitso chazakuwopsa ndi zotsatira zoyipa za Onglisa osakwanitsa zaka 18.

Kugwirizana kwa Onglisa ndi insulin panthawi yamankhwala sikunafufuzidwe. Palibe deta pazomwe zimagwiritsa ntchito mankhwalawa poyendetsa komanso zochitika ndi makina osinthika. Chizungulire zitha kuchitika pambuyo kumwa mankhwalawo.

Zokhudza zomwe zimagwira thupi la mayi wapakati komanso mkaka wake sizinaphunzire. Palibe chidziwitso ngati chinthu chomwe chikugwira chikutha kulowa m'chiberekero kupita ku mwana wosabadwayo, motero mankhwalawa sanalembedwe nthawi ino. Ngati sikotheka kupewa kugwiritsa ntchito Onglisa, panthawi yomwe mumamwa mankhwalawa, kuyamwitsa kumayima. Pankhaniyi, kuopsa kwa mwana komanso zovuta zomwe zingachitike kwa mayi zimaganiziridwa.

Sulfonylurea zotumphukira kwambiri amachepetsa shuga. Kupewa matenda amtunduwu limodzi ndi Onglisa, ndikofunikira kuti muchepetse mlingo wa sulfonylurea kapena insulin.

Pokhala ndi mbiri yakuwunika kwakukulu kwa odwala matenda ashuga (kuphatikizapo momwe thupi limagwirira ndi Quincke's edema), Ongliza sagwiritsidwa ntchito pakugwiritsa ntchito zoletsa zina za DPP-4. Ndikofunikira kuzindikira zomwe zimayambitsa hypersensitivity ndikuwonetsa njira zina zochizira (analogues za mankhwala Onglisa).

Pali umboni wa kapamba pachimake ndi kugwiritsa ntchito mankhwalawa. Odwala ayenera kudziwitsidwa zamtunduwu popereka Onglisa. Ngati mukuwoneka kuti mukuwonetsedwa kwa zizindikiro zoyambirira za kapamba, mankhwalawa amachotsedwa.

Kuphatikizika kwa mapiritsi kumakhala ndi lactose, chifukwa chake, odwala matenda ashuga omwe ali ndi chibadwa cha galactose tsankho, kuchepa kwa lactase sikungatenge Onglisa.

Kuchita ndi mankhwala ena

Chithandizo choyambirira ndi metformin pakufunika kwa kusintha kwa moyo. Ngati chithandizo chotere sichikubweretsa zotsatira zoyembekezeredwa, mankhwala ena ovomerezeka amayamba.

Kafukufuku wachitika omwe akuwonetsa kuti pali chiopsezo chochepa cha kuphatikiza kwa saxagliptin ndi mankhwala ena.

Kugwiritsa ntchito palimodzi ndi ma inducers a CYP 3A4 / 5 isoenzymes kumathandiza kuchepetsa zomwe zili mu saxagliptin metabolic product.

Kutenga mankhwala a sulfonylurea kumachepetsa kwambiri kuchuluka kwa shuga m'magazi. Kuti mupewe chiopsezo chotere, ndikofunikira kuti muchepetse mlingo wa mankhwala Onglisa.

Palibe maphunziro omwe adachitika pazotsatira za kusuta, kudya, kapena kumwa mowa pa saxagliptin.

Njira zopewera

Onglisa ndi mankhwala otetezeka, zotsatira zosakonzekera sizimachitika. Pali zinthu zambiri zoyipa zomwe zimachitika ndi saxagliptin monga chithandizo cha placebo.

Kugwiritsa ntchito Onglises ndizoletsedwa pomwe:

• mtundu 1 shuga
• mogwirizana ndi insulin
• kuchepa kwa mkaka,
• matenda ashuga ketoacidosis,
• mimba
• yoyamwitsa
• wosakwana zaka 18
• kusalolera kwa chimodzi mwazigawo za mankhwala.

Ndikofunikira kuti odwala azigwiritsa ntchito:

• akuvutika kwambiri ndi vuto laimpso kapena chifuwa chachikulu m'mbuyomu,
• okalamba
• kugwiritsa ntchito munthawi yomweyo ndi sulfonylureas.

Mu chithandizo cha Onglisa, pamakhala zovuta zina:

• matenda a kwamkodzo thirakiti
• chapamwamba kupuma thirakiti matenda
• kutupa kwa sinus mucosa,
• kutupa kwam'mimba ndi matumbo aang'ono,
• akukumbutsa
• pachimake kapamba
• migraines.

Ndi mankhwala osakanikirana ndi metformin, nasopharyngitis imadziwonekera nthawi zina.

Hypersensitivity idadziwika mu 1.5% yamilandu, sinaopseze moyo, ndipo kuchipatala sikunafunike.

Mukamayikidwa limodzi ndi thiazolidinediones, kuweruza ndi kuwunika kwa Onglise, kupezeka kwa edema yofowoka kapena yapakati kunadziwika, komwe sikunafunikire kuti kutha kwa chithandizo.

Zovuta za hypoglycemia panthawi ya chithandizo ndi Ongliza zinali zogwirizana ndi zotsatira zake ndi placebo.

Bongo

Pogwiritsa ntchito mankhwalawa kwa nthawi yayitali, zizindikiro za poizoni sizifotokozedwa. Pankhani ya bongo, Zizindikiro ziyenera kutsitsimuka. The yogwira thunthu ndi kagayidwe kachakudya mankhwala amuchotsa ndi hemodialysis.

Analogs Onglises okhala ndi zinthu zomwezi omwe mulibe. Ili ndiye mankhwala okhawo omwe ali ndi saxagliptin. Zofanana pa thupi zimaphatikizidwa ndi Nesin, Trigueent, Galvus. Sizoletsedwa kugwiritsa ntchito analogi za Ongliz popanda chilolezo cha adokotala.

Mankhwala a shuga a Onglis amathandizira kuti magazi a shuga aziwongolera. Mapiritsi ndiosavuta kutenga. Ndikutha kuwona mwayi womwe sindinawone zotsatira zoyipa. Mwa maminiti, nditha kutchula mayina ochulukirachulukira.

Ndimakonda mankhwala Onglisa, pali malangizo omveka bwino ogwiritsa ntchito, ndi osavuta kugwiritsa ntchito. Nthawi zina mutu wochepa. Ndikupangira mankhwalawa.

Chithandizo cha Ongliza ndikuyimira gulu latsopano la mankhwala ochepetsa shuga. Ili ndi njira yosinthira mosiyanasiyana, koma mwanjira yofananira imafanana ndi mankhwala achikhalidwe, ndipo pachitetezo imapambana. Mankhwalawa ali ndi phindu pa matenda oyanjana, amalepheretsa matenda a shuga komanso zovuta zina.

Ubwino wosakayikiridwa ndi kusapezeka kwa chiwopsezo cha hypoglycemia, zimakhudza kulemera kwa wodwala komanso mwayi wogwiritsa ntchito mankhwala ena ochepetsa shuga. M'tsogolomu, asayansi akufuna kupanga mankhwala omwe adzabwezeretsenso chida cha pancreatic kwa nthawi yayitali.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

Aronova S.M. adafotokoza za chithandizo cha matenda ashuga. Werengani kwathunthu