Insulin Humalog ndi DNA yosinthika ya insulin ya anthu. Chochititsa chidwi ndi kusintha kwa kuphatikiza kwa ma amino acid mu insulin B.

Mankhwala amawongolera njirayi shuga kagayidwe ndipo ali nazo anabolic zotsatira. Zilowetsedwa m'matumba a minofu ya anthu, zomwe zimakulirakulira zimachuluka glycerol, glycogenmafuta acids kumathekamapuloteni kaphatikizidwe, kumwa ma amino acid kukukula, komabe, kukuchepa gluconeogenesis, ketogenesis, glycogenolysis, lipolysiskumasulidwa ma amino acidndi catabolism mapuloteni.

Ngati alipo shuga 1ndi2mitundu yandi kumayambiriro kwa mankhwala atatha kudya, kutchulidwa kokwanira hyperglycemiaZokhudza insulin ya munthu. Kutalika kwa Lizpro kumasiyanasiyana ndipo kumatengera zinthu zambiri - mlingo, kutentha kwa thupi, jakisoni, magazi, kuchita masewera olimbitsa thupi.

Makonzedwe a insulin a Lizpro amaphatikizidwa ndi kuchepa kwa ziwonetsero nocturnal hypoglycemia Odwala omwe ali ndi matenda a shuga, ndipo zochita zake poyerekeza ndi insulin ya anthu zimachitika mofulumira (pafupifupi pambuyo mphindi 15) ndipo zimakhala zazifupi (kuyambira maola 2 mpaka 5).

Humalog, malangizo ogwiritsira ntchito

Mlingo wa mankhwalawa umayikidwa payekha kutengera mphamvu ya odwala exo native insulin ndi momwe alili. Ndikulimbikitsidwa kupatsa mankhwala osapitirira mphindi 15 musanadye kapena mutatha kudya. Njira yoyendetsera ntchito ndi payokha. Pochita izi, kutentha kwa mankhwala akhale pamalo oyenera.

Zofunikira zatsiku ndi tsiku zimatha zosiyanasiyana, mpaka nthawi zambiri zimakhala 0.5-1 IU / kg. Mtsogolomo, tsiku ndi tsiku Mlingo umodzi wa mankhwalawo umasinthidwa malinga ndi momwe wodwala amagwirira ntchito ndi zambiri kuchokera ku mayeso angapo a magazi ndi mkodzo wa glucose.

Intravenous management ya Humalog imachitika ngati muyezo wa jekeseni wovomerezeka. Jakisoni wotsekemera amapangidwa m'apewa, matako, ntchafu kapena pamimba, nthawi ndi nthawi kuwasinthana osaloleza kugwiritsa ntchito malo amodzimodzi kamodzi pamwezi, ndipo malo omwe jakisoniyo sayenera kutenthedwa. Pakati pa njirayi, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Wodwala ayenera kuphunzira njira yolondola ya jakisoni.

Bongo

Mankhwala osokoneza bongo amatha kuyambitsa hypoglycemiaNdikuphatikizidwa ndi zoopsa, thukuta, kusanza, mphwayikunjenjemera, kusokonezeka kwa chikumbumtima, tachycardiamutu. Nthawi yomweyo, hypoglycemia imatha kuchitika osagwiritsa ntchito mankhwala osokoneza bongo okha, komanso zotsatira zake kuchuluka kwa insulinchifukwa cha mphamvu yamagetsi kapena kudya. Kutengera kuuma kwa hypoglycemia, njira zoyenera zimatengedwa.

Kuchita

Hypoglycemic zotsatira za mankhwala amachepetsa, mankhwala mahomoni a chithokomiro, GKS, beta 2-adrenergic agonists, tridclic antidepressants, okodzetsa, Diazoxide,, zochokera phenothiazine, nicotinic acid.

Hypoglycemic zotsatira za mankhwalawa zimatheka anabolic steroids, opanga betamankhwala okhala ndi Mowa Fenfluramine, manzeru, Guanethidine, Mao zoletsa, m`kamwa hypoglycemic mankhwala, salicylates, sulfonamides, ACE zoletsa, .

Humalog in syringe cholembera: mawonekedwe

Humalog ndi mtundu wosinthika wa DNA wa insulin yaumunthu. Chofunikira chake ndikusintha pakuphatikizidwa kwa ma amino acid mu insulin. Mankhwala amawongolera kagayidwe ka shuga. Imakhala ndi anabolic.

Humalog Insulin Cartridges

Ndi kuyambitsidwa kwa Humalog, kuchuluka kwa glycogen, glycerol, mafuta acids kumawonjezeka. Kuphatikizika kwa mapuloteni kumathandizidwanso. Kuledzera kwa amino acid kumakulira. Nthawi yomweyo, ketogenesis, gluconeogeneis, lipolysis, glycogenolysis, mapuloteni catabolism ndi kutulutsidwa kwa amino acid kumachepetsedwa. Humalog ndi insulin yochepa.

Zogwira ntchito

Gawo lalikulu la Humalog ndi insulin lispro.

Makatoni amodzi ali ndi 100 IU.

Kuphatikiza apo, pali zinthu zothandiza: glycerol, zinc oxide, sodium hydroxide 10% solution, hydrochloric acid 10% solution, sodium hydrogen phosphate heptahydrate, metacresol, madzi a jekeseni.

Kusakaniza kwa Insulin Humalog: 25, 50, 100

Matenda a shuga amawopa mankhwalawa, ngati moto!

Muyenera kungolemba ...

Kusakaniza kwa Humalog 25, 50 ndi 100 kumasiyana ndi mtundu wamba wa Humalog mwa kukhalapo kwa chinthu chowonjezera - gawo la proteni Hagedorn (NPH).

Izi zimathandizira kuti muchepetse kuchita insulin.

Posakaniza mankhwala, 25, 50 ndi 100 zimawonetsa kuchuluka kwa NPH. Izi zikakhala zochulukirapo, kulimbitsa thupi kwa jakisoni ndikutali. Ubwino ndikuti amachepetsa kuchuluka kwa jakisoni tsiku ndi tsiku.

Izi zimathandizira njira yochiritsira ndikupangitsa moyo wa munthu wodwala matenda ashuga kukhala bwino. Choipa chosakanikirana cha Humalog ndikuti sichimapereka kuyendetsa bwino kwa shuga wa plasma. NPH nthawi zambiri imayambitsa kusagwirizana, maonekedwe angapo oyipa.

Endocrinologists samakonda kupereka kusakaniza, chifukwa chithandizo chimayambitsa zovuta komanso zovuta za matenda ashuga.

Mitundu ya insulin iyi ndi yoyenera kwa odwala matenda ashuga okha, omwe moyo wawo ndi waufupi, demilea. M'magulu ena a odwala, madokotala amalimbikitsa mwamphamvu kugwiritsa ntchito Humalog yoyera.

Malangizo ogwiritsira ntchito

Humalog ikuwonetsedwa kuti athandize odwala matenda ashuga achikulire ndi ana omwe amafunikira insulini tsiku lililonse kuti akhalebe magazi.

Mlingo komanso kuchuluka kwa mankhwalawa zimagwiritsidwa ntchito ndi dokotala. Mankhwala amatha kutumikiridwa intramuscularly, subcutaneous kapena kudzera m'mitsempha. Njira yotsirizirayi yogwiritsira ntchito ndiyoyenera pazipatala zokha.

Intravenous management kunyumba imakhudzana ndi zoopsa zina. The humalogue mu cartridgeges imalowetsedwa mosadukiza pogwiritsa ntchito cholembera.

Mankhwalawa ayenera kugwiritsidwa ntchito mphindi 5-15 musanakhazikitse chakudya kapena mukangodya. Jakisoni amachitidwa katatu pa tsiku. Ngati wodwalayo adapangidwira insulin yayitali, ndiye kuti Humalog imabayidwa katatu patsiku.

Mlingo waukulu wa mankhwalawa umayikidwa ndi dokotala. Kupitilira kumaloledwa pazokha. Mankhwalawa amaloledwa kuphatikizidwa ndi fanizo lina la insulin yaumunthu. Kuti muchite izi, onjezerani mankhwala ena ku cartridge.

Mapensulo amakono amasirikali amathandizira kuti jakisoni apangidwe. Asanagwiritse ntchito, cartridge imafunika kuti igudwe m'manja. Izi zimachitika kuti zomwe zili mkati mwake zikhale zofanana muutoto ndi kusasinthasintha. Osagwedeza katoni mwamphamvu. Kupanda kutero, thovu lingapangire, zomwe zingasokoneze kuyambitsa ndalama.

Otsatirawa amafotokozera za algorithm yopanga jakisoni moyenera:

• sambani m'manja ndi sopo,
• sankhani malo jakisoni ndi kupukuta ndi mowa,
• sansani cholembera ndi cholembera kuti ayikemo mosiyanasiyana kapena mutembenukire kangapo ka 10. Njira yothetsera vutoli iyenera kukhala yofanana, yopanda utoto komanso yowonekera. Osagwiritsa ntchito cartridge yokhala ndi mitambo, utoto, kapena wandiweyani. Izi zikutanthauza kuti mankhwalawa adachepa chifukwa chakuti adasungidwa molakwika kapena tsiku lotha ntchito lidatha,
• ikani mlingo
• chotsani kansalu pachibowo,
• konzani khungu
• ikani singano yonse pakhungu. Poterepa, muyenera kusamala kuti musalowe mumtsempha wamagazi,
• dinani batani m'manja ndi kuligwira,
• Pamene buzzer ikulira kuti mumalize jakisoni, dikirani masekondi 10 ndikuchotsa singano. Pa chizindikiro, mlingo uyenera kukhala wopanda ziro,
• Chotsani magazi omwe adawoneka ndi swab thonje. Simungathe kupukusa kapena kupukuta malo a jekeseni pambuyo pa jekeseni,
• ikani chophimba pazotengera.

Kutentha kwa njira yovulazidwa kuyenera kukhala kutentha kwa chipinda. Pang'onopang'ono, mankhwalawa amapakidwa m'chafu, phewa, m'mimba kapena matako. Kuyala nthawi ili yonse pamalo osavomerezeka. Malo a thupi azisinthidwa pamwezi.

Asanagwiritse ntchito komanso atatha kutsatira, wodwalayo amafunika kuyeza shuga wamagazi ndi glucometer. Kupanda kutero, pamakhala chiopsezo cha hypoglycemia.

Humalog ili ndi zotsutsana zina:

• achina,
• tsankho kwa insulin lyspro kapena zinthu zina za mankhwala.

Mukamagwiritsa ntchito Humalog, ziyenera kukumbukiridwa kuti mothandizidwa ndi mankhwala ena, kufunika kwa jakisoni kumasintha.

Mwachitsanzo, njira zakulera zamkamwa, corticosteroids zimakhala ndi hyperglycemic. Chifukwa chake, muyenera kupereka mankhwalawa muyezo waukulu. Mukamamwa mapiritsi a antidiabetesic, antidepressants, salicylates, ACE inhibitors, beta-blockers, kufunika kwa insulin kumachepetsedwa.

Humalog imaloledwa kugwiritsidwa ntchito panthawi yapakati. Palibe zoyipa zomwe zimapezeka mwa amayi omwe amagwiritsa ntchito jakisoni wa mankhwalawa. Chochita sichikhudza thanzi la mwana wosabadwa kapena wakhanda. Koma panthawiyi, muyenera kuyang'anitsitsa kuchuluka kwa shuga m'magazi.

Mu trimester yoyamba, kufunika kwa insulin nthawi zambiri kumachepa, ndipo m'nthawi yachiwiri ndi yachitatu kumawonjezeka. Pa mkaka wa m`mawere, kusintha kwa insulin kungafunikire.

Mulibe malire ofotokoza bongo. Kupatula apo, kuchuluka kwa shuga m'madzi a m'magazi ndi chifukwa cha mgwirizano wamphamvu pakati pa insulin, kupezeka kwa glucose, ndi metabolism.

Ngati mungalowe kwambiri, hypoglycemia idzachitika. Pankhaniyi, pali zotsatirazi: Hypoglycemia yolimbitsa thupi nthawi zambiri imachotsedwa pakumwa mapiritsi a shuga, zopangidwa ndi shuga.

Pofuna kupewa hypoglycemia pakusintha kwa Humalog, muyenera kuyang'anira moyo wanu. Mungafunike kusintha zakudya zanu, masewera olimbitsa thupi, kusankha mankhwala.

Kuzunza kwambiri kwa hypoglycemia, komwe kumayendetsedwa ndi minyewa yamitsempha, chikomokere, kumafunikira minyewa kapena kugwiriratu ntchito kwa glucagon. Ngati izi sizikuchitika pompopompo. Wodwala akayambanso kuzindikira, amafunika kudyetsedwa chakudya chamafuta, popeza pamakhala chiopsezo cha hypoglycemia mobwerezabwereza.

Mukamagwiritsa ntchito Humalog, zotsatira zoyipa zimatha kuchitika:

• matupi awo sagwirizana. Amawonedwa kawirikawiri, koma ndizovuta kwambiri. Wodwala amatha kupuma movutikira, kuyabwa mthupi lonse, thukuta, kuthamanga kwa mtima, kutsika kwa magazi, kuvutika kupuma. Mkhalidwe wowopsa ukuwopseza moyo
• hypoglycemia. Zotsatira zoyipa kwambiri za mankhwala a hypoglycemic,
• komwe jakisoni wachitika (zotupa, redness, kuyabwa, lipodystrophy). Amadutsa patapita masiku angapo, masabata.

Humalog iyenera kusungidwa m'malo owuma komanso amdima pamtunda wa +15 mpaka +25 degrees. Mankhwalawa sayenera kutenthetsedwa pafupi ndi chowotcha mafuta kapena pa batri. Katiriji amayenera kugwiridwa m'manja.

Pali malingaliro ambiri a Humalog mu syringe cholembera. Ndipo ambiri mwaiwo ndi abwino:

• Natalya. Ndili ndi matenda ashuga. Ndimagwiritsa ntchito Humalog mu cholembera. Zabwino kwambiri. Shuga amatsika msanga. M'mbuyomu, adalowetsa Actrapid ndi Protafan. Ku Humalog ndikumva bwino komanso ndikulimba mtima. Hypoglycemia sichimachitika,
• Olga. Ndili ndi matenda ashuga chaka chachiwiri.Munthawi imeneyi ndinayesa ma insulini osiyanasiyana. Wogwira ntchito kwa nthawi yayitali adatola pomwepo. Koma ndimankhwala osakhalitsa kwa nthawi yayitali sindinathe kusankha. Mwa onse odziwika, Humalog mu Quick Pen syringe ndiyo inali yoyenera kwambiri kwa ine. Iwo mwachangu komanso moyenera amachepetsa shuga. Chifukwa cha chogwiririra ndikosavuta kugwiritsa ntchito. Lisanayambike, ndimawerengera magawo a mkate ndikusankha muyeso. Patha theka la chaka ku Humalog ndipo pakadali pano sindingasinthe,
• Andrey. Chaka chachisanu odwala matenda ashuga. Nthawi zonse amazunzidwa ndimalumpha yamagazi. Posachedwa, ndidasinthidwa kupita ku Humalog. Ndikumva bwino tsopano, mankhwalawa amapereka chipepeso chabwino. Chokhacho chingabweretse mtengo wokwera,
• Marina Ndakhala ndikudwala matenda ashuga kuyambira zaka 10. Mpakafika zaka 12, adamwa mapiritsi ochepetsa shuga. Koma kenako adasiya kundithandiza. Chifukwa cha izi, endocrinologist adalimbikitsa kusintha insulin Humalog. Sindikufuna izi ndikukana. Koma masomphenya atayamba kuwonongeka, komanso mavuto a impso, ndidavomera. Sindinadandaule ndi lingaliro langa. Kupanga jakisoni sikowopsa. Shuga tsopano sakukwera pamwamba pa 10. Ndine wokondwa ndi mankhwalawa.

Makanema okhudzana nawo

Malangizo ogwiritsira ntchito insulin Humalog mu kanema:

Chifukwa chake, Humalog mu cholembera sichingwe ndi mankhwala abwino kwambiri kwa anthu omwe ali ndi matenda a shuga. Imakhala ndi zotsutsana zingapo komanso zoyipa zake. Chifukwa cha cholembera, syringe yokhazikika ndi kayendetsedwe ka mankhwala zimapangidwa mosavuta. Odwala ali ndi lingaliro labwino pankhani yamtunduwu wa insulin.

Insulin humalogue yopangidwa ndi French komanso mawonekedwe a kayendetsedwe kake pogwiritsa ntchito cholembera. Malangizo a Humalog ogwiritsira ntchito

Munkhaniyi, mutha kuwerengera malangizo ogwiritsira ntchito mankhwalawa Chichewa . Amapereka ndemanga kuchokera kwa alendo omwe amabwera patsamba lino - ogula mankhwalawa, komanso malingaliro a akatswiri azachipatala pakugwiritsa ntchito Humalog machitidwe awo. Chopempha chachikulu ndikuti muwonjezere ndemanga zanu za mankhwalawa: mankhwalawo adathandizira kapena sanathandizire kuchotsa matendawa, ndizovuta ziti zomwe zimawoneka ndi zotsatirapo zake, zomwe mwina sizinalengezedwe ndi wopanga. Ma Analogs a Humalog pamakhala ma analogues omwe amapezeka. Gwiritsani ntchito pochiza matenda amiseche 1 amtundu wa shuga (wodalira insulin komanso osadalira insulin) mwa akulu, ana, komanso panthawi yoyembekezera komanso mkaka wa m'mawere. The zikuchokera mankhwala.

Chichewa - analogue ya insulin yaumunthu, imasiyana ndi kusintha kwatsatanetsatane wa proline ndi lysine amino acid zotsalira pamalo 28 ndi 29 a insulin B. Poyerekeza ndikukonzekera kwanthaŵi yayitali insulin, lyspro insulin imadziwika ndi kuyambika mwachangu komanso kutha kwake, komwe kumachitika chifukwa chakuchotsa kwina kuchokera kumalo osasunthika chifukwa cha kusungidwa kwa mawonekedwe a monomeric a lyspro insulin mamolekyulu mu yankho. Kukhazikika kwa mphindi 15 pambuyo pa kayendetsedwe ka subcutaneous, mphamvu yayikulu imakhala pakati pa maola 0.5 ndi maola 2,5, kutalika kwa nthawi ndi maola 3-4.

Humalog Mix ndi DNA - maumboni odziwika a insulin yaumunthu ndipo ndi chosakanikirana chopangidwa chopangidwa ndi lyspro insulin solution (analog yothamanga ya insulin yaumunthu) ndi kuyimitsidwa kwa lyspro protamine insulin (anthawi yapakati ya insulin analogue).

Chochita chachikulu cha insulin lyspro ndi malamulo a kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogenesis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Lyspro insulin + akubwera.

Kukwanira kwathunthu ndi kuyambika kwa mphamvu ya insulin kumadalira malo a jakisoni (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), komanso kuchuluka kwa insulin pokonzekera. Imagawidwa mosiyanasiyana mu minofu. Simadutsana chotchinga ndi mkaka wa m'mawere. Amawonongedwa ndi insulinase makamaka m'chiwindi ndi impso. Amachotseredwa ndi impso - 30-80%.

• lembani matenda a shuga 1 mellitus (wodalira insulin), kuphatikiza ndi tsankho kukonzekera kwina kwa insulin, ndi postprandial hyperglycemia yomwe singathe kukonza ma insulin, kukonzekera kwachulukidwe kakang'ono ka insulini (kuthamanga kwa kuchepa kwa insulin),
• lembani matenda a shuga 2 oletsa kutsatsa

Njira yothetsera kulowetsedwa kwamkati mwa 100 IU mu katoni kathengo ka 3 ml wophatikizidwa ndi cholembera cha QuickPen kapena cholembera.

Kuyimitsidwa kwa subcutaneous makonzedwe a 100 IU mu katoni 3 ml wophatikizidwa ndi cholembera cha QuickPen kapena cholembera (Humalog Remix 25 ndi 50).

Mitundu ina ya kumwa, ngati mapiritsi kapena mapiritsi, kulibe.

Malangizo ogwiritsira ntchito ndi njira yogwiritsira ntchito

Mlingo umayikidwa payekha. Lyspro insulin imayang'aniridwa subcutaneous, mu mnofu kapena kudzera m'mitsempha 5-15 asanadye. Mlingo umodzi ndi 40 magawo, owonjezera amangololedwa pokha pokha. Ndi monotherapy, Lyspro insulin imayang'aniridwa katatu pa tsiku, pamodzi ndi kukonzekera kwa insulin yayitali - katatu patsiku.

Mankhwalawa amayenera kuperekedwa mosavuta.

Intravenous makonzedwe a mankhwala Humalog Remix ali contraindicated.

Kutentha kwa mankhwala omwe amaperekedwa kuyenera kukhala kutentha kwambiri.

Subcutaneally ayenera jekeseni phewa, ntchafu, matako kapena m'mimba. Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 pamwezi. Mukamayambitsa mankhwalawa Humalog, chisamaliro chiyenera kutengedwa kuti mupewe magazi. Pambuyo pa jakisoni, tsamba la jakisidwe siliyenera kutenthedwa.

Poika makatoni mu chipangizo cha jakisoni wa insulin ndikulowa ndi singano musanayendetsedwe ka insulin, malangizo a wopanga chipangizo cha insulin amayenera kuwonetsetsa.

Malangizo akukhazikitsa mankhwala Humalog Remix

Kukonzekera mawu oyamba

Musanagwiritse ntchito, cartridge yosakanikirana ya Humalog Mix iyenera kukukhidwira pakati pama manja khumi ndikugwedezeka, kutembenuka ndi 180 ° komanso maulendo khumi kuti ipatsenso insulin mpaka iwoneke ngati madzi osalala kapena mkaka. Gwedezani mwamphamvu, monga izi zimatha kuyambitsa foam, zomwe zingasokoneze mlingo woyenera. Kupangitsa kusakanikirana, katiriji kamakhala ndi mkanda wawung'ono wagalasi. Mankhwala sayenera kugwiritsidwa ntchito ngati ali ndi ziphuphu mutatha kusakaniza.

Momwe mungapangire mankhwalawa

1. Sambani manja.
2. Sankhani malo pobayira.
3. Chitani khungu ndi antiseptic pamalo omwe jakisoni (ndi kudzivulaza, mogwirizana ndi malingaliro a dokotala).
4. Chotsani kapu yakunja yoteteza ku singano.
5. Sinthani khungu ndikakukoka kapena kusunga khola lalikulu.
6. Ikani singano pang'onopang'ono ndikuchita jakisoni mogwirizana ndi malangizo ogwiritsa ntchito cholembera.
7. Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.
8. Pogwiritsa ntchito chopukutira chakunja cha singano, dulani singano ndikuwononga.
9. Ikani chipewa pa cholembera.

• hypoglycemia (hypoglycemia yayikulu imatha kutha kwa chikumbumtima ndipo, mwapadera, mpaka kufa),
• redness, kutupa, kapena kuyabwa pamalowo jakisoni (nthawi zambiri zimatha patadutsa masiku angapo kapena masabata, nthawi zina izi zimachitika chifukwa cha zifukwa zosagwirizana ndi insulin, mwachitsanzo, kupweteka pakhungu ndi jakisoni woletsa kapena jekeseni wosayenera),
• kuyamwa kofananira
• kuvutika kupuma
• kupuma movutikira
• kutsika kwa magazi,
• tachycardia
• kutuluka thukuta kwambiri
• chitukuko cha lipodystrophy pamalo jakisoni.

• achina,
• Hypersensitivity pamagawo a mankhwala.

Mimba komanso kuyamwa

Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena mkhalidwe wa mwana wosabadwa ndi wakhanda zadziwika.

Cholinga cha mankhwala a insulin panthawi yapakati ndikukhazikika pakukhazikika kwa shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.

Amayi amisinkhu yokhala ndi matenda ashuga ayenera kudziwitsa adotolo za kuyambika kapena kukhala ndi pakati.

Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Njira yoyendetsera njira yomwe imagwiritsidwa ntchito mulingo wa lyspro insulin uyenera kuyang'aniridwa bwino. Posamutsa odwala kuchokera ku insulin yomwe imakonzekera mwachangu kuchokera ku insulin lispro, kusintha kofunikira kungafunike. Kusamutsidwa kwa odwala omwe amalandira insulin tsiku lililonse mlingo wopitilira 100 PESCES kuchokera ku mtundu umodzi wa insulin kupita ku ina ndikulimbikitsidwa kuti upangidwe mu chipatala.

Kufunika kwa insulin kumatha kuwonjezeka panthawi yomwe matenda opatsirana, ndi nkhawa zam'maganizo, ndi kuchuluka kwa chakudya chamagulu mu chakudya, pazakudya zowonjezera zamankhwala omwe ali ndi vuto la hyperglycemic (mahomoni a chithokomiro, glucocorticoids, kulera kwapakamwa, thiazide diuretics).

Kufunika kwa insulin kumatha kuchepa ndi kuchepa kwaimpso komanso / kapena chiwindi, ndi kuchepa kwa kuchuluka kwa chakudya chamagulu m'zakudya, ndi kuchuluka kwa thupi, pakudya kowonjezereka kwa mankhwala omwe ali ndi hypoglycemic zochita (mao inhibitors, osasankha beta-blockers, sulfonamides).

Malangizo a hypoglycemia mu mawonekedwe owopsa amatha kuchitika ndikugwiritsa ntchito i / m ndi / kapena s / glu wa glucagon kapena iv woyendetsa shuga.

Mphamvu ya hypoglycemic ya Lyspro insulin imakonzedwa ndi Mao inhibitors, osagwiritsa ntchito beta-blockers, sulfonamides, acarbose, ethanol (mowa) ndi mankhwala okhala ndi ethanol.

Mphamvu ya hypoglycemic ya Lyspro insulin imachepetsedwa ndi glucocorticosteroids (GCS), mahomoni a chithokomiro, njira zakulera zamkati, thiazide diuretics, diazoxide, antidepressants a tricyclic.

Beta-blockers, clonidine, reserpine amatha kuphimba mawonetseredwe a zizindikiro za hypoglycemia.

Mndandanda wa mankhwala Humalog

Zofanana muzochitika zamagulu:

• Lyspro insulin
• Humalog Mix 25,
• Kusintha kwa Humalog 50.

Analogs mu pharmacological group (ma insulin):

• Actrapid HM Penfill,
• Actrapid MS,
• B-Insulin S.Ts. Berlin Chemie,
• Berlinsulin H 30/70 U-40,
• Berlinsulin H 30/70 cholembera,
• Berlinsulin N Basal U-40,
• Berlinsulin N Basal chole,
• Berlinsulin N Normal U-40,
• Berlinsulin N Wokhazikika Peni,
• Depot insulin C,
• Isofan Insulin World Cup,
• Iletin
• Thumba la Insulin SPP,
• Insulin c
• Nkhumba ya insulin yoyeretsedwa kwambiri,
• Insuman Comb,
• Intral SPP,
• World Cup,
• Combinsulin C
• Mikstard 30 NM Penfill,
• Monosuinsulin MK,
• Monotard
• Pensulin,
• Protafan HM Pofikira,
• Protafan MS,
• Rinsulin
• Ultratard NM,
• Nyumba 40,
• Kandachime 40,
• Humulin.

Pakusowa kwa kufananiza kwa mankhwala omwe amagwira ntchito, mutha kuwonekera pazolumikizana pansipa ndi matenda omwe mankhwala oyenera amathandizira ndikuwona mawonekedwe ofananira achire.

Mtundu wapamwamba kwambiri wamankhwala a French insulin Humalog watsimikizira kuposa apamwamba ake, omwe amapezeka kudzera pakuphatikiza kwabwino pazinthu zazikulu zogwira ntchito komanso zothandiza. Kugwiritsa ntchito insulini iyi kumathandizanso kwambiri kuti athane ndi hyperglycemia mwa odwala omwe ali ndi matenda ashuga.

Insulin humalogue yopangidwa ndi French komanso mawonekedwe a kayendetsedwe kake pogwiritsa ntchito cholembera. Zambiri pazakugwiritsa ntchito mosamala ndi cholembera. Dzina ndi adilesi yaopanga

Mu cholembera.Malangizo ogwiritsa ntchito chida ichi aperekedwa m'nkhaniyi.

Humalog ndi mtundu wosinthika wa DNA wa insulin yaumunthu. Chofunikira chake ndikusintha pakuphatikizidwa kwa ma amino acid mu insulin. Mankhwala amawongolera kagayidwe ka shuga. Imakhala ndi anabolic.

Humalog Insulin Cartridges

Ndi kuyambitsidwa kwa Humalog, kuchuluka kwa glycogen, glycerol, mafuta acids kumawonjezeka. Kuphatikizika kwa mapuloteni kumathandizidwanso. Kuledzera kwa amino acid kumakulira. Nthawi yomweyo, ketogenesis, gluconeogeneis, lipolysis, glycogenolysis, mapuloteni catabolism ndi kutulutsidwa kwa amino acid kumachepetsedwa. Humalog ndi insulin yochepa.

Njira yogwiritsira ntchito

Malangizo oyendetsera mankhwalawa Humalog

Kukonzekera mawu oyamba

Yankho la mankhwalawa Humalog liyenera kukhala loonekera komanso lopanda utoto. Njira yothira ngati yafinya, kapena yakuwala pang'ono,

Mukakhazikitsa cartridge mu syringe cholembera (cholembera), ndikulowa ndi singano ndikuchita jakisoni wa insulin, ndikofunikira kutsatira malangizo a wopanga omwe amaphatikizidwa ndi cholembera chilichonse.

Sambani manja.
Sankhani malo pobayira.
Chitani khungu ndi antiseptic pamalo a jekeseni.
Chotsani kapu ku singano.
Sinthani khungu ndikakukoka kapena kusunga khola lalikulu. Ikani singano molingana ndi malangizo ogwiritsa ntchito cholembera.
Kanikizani batani.
Chotsani singano ndikufinya pang'onopang'ono malo a jakisoni kwa masekondi angapo. Osatupa malo a jakisoni.
Pogwiritsa ntchito chopukutira cha singano, vulani singano ndikuwononga.
Masamba a jakisoni ayenera kusinthidwa kuti malo omwewo asagwiritsidwerenso nthawi 1 mwezi uliwonse.
Insulinven insulin
Jakisoni wovomerezeka wa Humalog uyenera kuchitika molingana ndi chizolowezi chachipatala cha jakisoni wamkati, mwachitsanzo, kulowetsedwa kwa bolus kapena kugwiritsa ntchito kulowetsedwa. Kuphatikiza apo, nthawi zambiri ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi.
Makina a kulowetsedwa okhala ndi zozungulira kuyambira 0,1 IU / ml mpaka 1.0 IU / ml ya insulin lispro mu 0.9% sodium chloride solution kapena 5% dextrose solution amakhala okhazikika firiji kwa maola 48.
Subcutaneous insulin kulowetsedwa ndi insulin pampu
Pobayira mankhwala a Humalog, mapampu Ochepera ndi Disetronic angagwiritsidwe ntchito kulowetsedwa kwa insulin. Muyenera kutsatira mosamalitsa malangizo omwe abwera ndi pampu. Njira ya kulowetsedwa imasinthidwa maola 48 aliwonse. Mukalumikiza dongosolo la kulowetsedwa, samalani malamulo aseptic. Pakachitika vuto la hypoglycemic, kulowetsaku kumayimitsidwa mpaka gawo litatsimikiza. Ngati pali shuga wobwereza mobwerezabwereza kapena wochepa kwambiri m'magazi, ndiye kuti muyenera kudziwitsa dokotala za izi ndikuganiza kuchepetsa kapena kuletsa kulowetsedwa kwa insulin. Kuperewera kwa pampu kapena kufalikira mu dongosolo la kulowetsedwa kumatha kubweretsa kukwera msanga kwamagazi. Ngati mukukayikira kuti akuphwanya insulin, muyenera kutsatira malangizowo ndipo ngati kuli koyenera dziwitsani adokotala. Mukamagwiritsa ntchito pampu, mankhwala a Humalog sayenera kusakanikirana ndi ma insulini ena.

Contraindication

Mimba komanso kuyamwa
Mpaka pano, palibe zotsatira zosasangalatsa za Lyspro insulin pa mimba kapena thanzi la mwana wosabadwayo / wakhanda. Palibe kafukufuku wokhudzana ndi mliri omwe adachitika.
Cholinga cha mankhwala a insulin panthawi yapakati ndikusunga chiwongolero chokwanira cha glucose mwa odwala omwe ali ndi matenda a shuga a shuga kapena omwe amadwala matenda a shuga. Kufunika kwa insulin nthawi zambiri kumachepera mu trimester yoyamba ndikuwonjezeka muyezo wachiwiri ndi wachitatu wama trimesters apakati. Nthawi yobadwa pambuyo pokhapokha ndipo mwayamba kubadwa, zofunika za insulin zimatha kugwa kwambiri.
Amayi amisinkhu yokhala ndi matenda ashuga ayenera kudziwitsa adotolo za kuyambika kapena kukhala ndi pakati. Pa nthawi yoyembekezera, odwala matenda a shuga amafunika kuwunika mosamala kuchuluka kwa shuga m'magazi, komanso kuwunika kachipatala kawirikawiri.
Odwala omwe ali ndi matenda a shuga mellitus nthawi yoyamwitsa, kusintha kwa insulin ndi / kapena zakudya kungafunike.

Malangizo apadera

Insellitus yodalira matenda a shuga ndi matenda omwe amadziwika kuti amafunikira insulin. Insulin imalowetsedwa.

Mpaka pano, makampani opanga mankhwala amapanga ma insulin osiyanasiyana pokonzekera odwala matenda ashuga, omwe adapangira jakisoni. Mankhwalawa osiyanasiyana amatha kukhala ndi mayina osiyanasiyana, mtundu wake komanso mtengo wake. Chimodzi mwa izo ndi Humalog insulin.

Pharmacokinetics

Ndi jekeseni wa subcutaneous, kuyamwa kwa lyspro insulin kumachitika mwachangu, Cmax yake imatheka pambuyo pa maola 1-2. Vd ya insulin popanga mankhwala ndi insulin wamba yamunthu ndiofanana, amachokera pa 0,26 mpaka 0,36 malita pa kilogalamu.

Njira yodalira shuga ya shuga

Njira yodalira shuga yosadalira insulin: kukana mankhwala omwe amaletsa matenda ashuga omwe amamwa pakamwa (malabsorption a mankhwala ena a insulin, postprandial hyperglycemia omwe sangathe kuwongolera), kuchitapo kanthu kwa opaleshoni ndi matenda omwe amagwirizana (omwe amaphatikizana ndi matenda a shuga).

Kugwiritsa

Mlingo Humalog umatsimikiziridwa payekhapayekha. Humalog mu mawonekedwe a Mbale imayendetsedwa zonse ndimkati komanso kudzera m'mitsempha komanso intramuscularly. The humalogue mu mawonekedwe a cartridgeges ndi subcutaneous okha. Jekeseni ikuchitika mphindi 1-15 asanadye.

Mwanjira yake yoyenera, mankhwalawa amaperekedwa kamodzi pa tsiku, kuphatikizidwa ndi insulin kukonzekera ndi nthawi yayitali, katatu tsiku lililonse. Kukula kwa gawo limodzi sikungathe kupitirira 40. Humalog mu Mbale ikhoza kusakanikirana ndi mankhwala a insulin omwe amakhala ndi mphamvu yayitali mu syringe imodzi.

Katoniyo sanapangirepo kuphatikiza Humalog ndi insulin ina yokonzekera mmenemo ndikuigwiritsa ntchito mobwerezabwereza.

Kufunika kochepetsa mlingo wa insulin kumatha kuchitika ngati kuchepa kwamankhwala kumapangidwe azakudya, kupsinjika kwakukulu kwa thupi, mankhwala owonjezera omwe ali ndi vuto la hypoglycemic - sulfonamides, osasankha beta-blockers.

Mukamamwa clonidine, beta-blockers ndi reserpine, zizindikiro za hypoglycemic nthawi zambiri zimachitika.

Zotsatira zoyipa

Zotsatira zazikulu za mankhwalawa zimayambitsa zotsatirazi: kutuluka thukuta, mavuto atulo, chikomokere. Nthawi zina, chifuwa ndi lipodystrophy zimatha kuchitika.

Pakadali pano, palibe zovuta zoyipa za Humalog pamikhalidwe ya mayi woyembekezera komanso mluza wapezeka. Palibe maphunziro omwe adachitika.

Mkazi wazaka zakubadwa yemwe ali ndi matenda ashuga ayenera kudziwitsa dokotala za mimba yomwe yakonzekereratu kapena yomwe ikubwera. Kwa odwala matenda ashuga, mkaka wa m'mawere nthawi zina umafuna kusintha kwa insulin kapena zakudya.

Kuphatikiza kwa mankhwala

Mphamvu ya hypoglycemic ya mankhwalawa imachepetsedwa mukamamwa mankhwala a pakhungu a chithokomiro, beta2-adrenergic agonists, danazole, antidepressants, thiazide-mtundu diuretics, diazoxide, chlorprotixen, isoniazid, nicotinic acid, lithiamu carbonate, lithiamu carbonate.

Zotsatira za hypoglycemic za Humalog zimawonjezeka ndi beta-blockers, ethyl mowa ndi mankhwala omwe amakhalapo, fenfluramine, anabolic steroids, tetracyclines, guanethine, salicylates, oral hypoglycemic mankhwala, sulfonamides, ACE zoletsa ndi MAO ndi octre.

Mankhwala sayenera kusakanikirana ndi zinthu zina zomwe zimakhala ndi insulin ya nyama.

Humalog ikhoza kugwiritsidwa ntchito (kuyang'aniridwa ndi achipatala) kuphatikiza ndi insulin yaumunthu, yomwe imakhala yothandiza kwakanthawi kochepa, kapena kuphatikiza ndi mankhwala a hypoglycemic omwe amatengedwa pakamwa, omwe ndi zotumphukira za sulfonylurea.

Malangizo ogwiritsira ntchito

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - kuyimitsidwa kwa kayendetsedwe ka kayendedwe kakang'ono: mtundu woyera, wokhazikika ndi mapangidwe otseguka komanso owoneka bwino, pafupifupi opanda maonekedwe kapena owoneka bwino, amasinthidwa mwachangu ndi kugwedeza modekha (3 ml mu cartridge, makatoni 5 mu chithuza, pakatoni yolongedza 1 chithuza, 3 ml pakatoni wopangidwa ndi cholembera cha syringe ya Quick Pen, mumakatoni a ma syringe 5, paketi iliyonse ilinso ndi malangizo ogwiritsira ntchito Humalog Remix 50).

Muli 1 ml ya kuyimitsidwa:

• yogwira mankhwala: insulin lispro - 100 International mayunitsi (ME),
• zothandizira: sodium hydrogen phosphate heptahydrate, protamine sulfate, phenol fluid, glycerol (glycerin), metacresol, zinc oxide, 10% sodium hydroxide solution ndi / kapena 10% hydrochloric acid solution, madzi a jekeseni.

Mlingo

Yankho la iv and sc management

insulin lispro 100 IU

Omwe amathandizira: glycerol (glycerin) - 16 mg, metacresol - 3,15 mg, zinc oxide (q.s. Zn2 + 0.0197 μg), sodium hydrogen phosphate heptahydrate - 1.88 mg, hydrochloric acid solution 10% ndi / kapena sodium hydroxide solution 10% - q.s. mpaka pH 7.0-8.0, madzi d / i - q.s. mpaka 1 ml.

Zizindikiro zogwiritsidwa ntchito

Humalog, malangizo ogwiritsira ntchito

Mlingo wa mankhwalawa umayikidwa payekha kutengera mphamvu ya odwala exo native insulin ndi momwe alili. Ndikulimbikitsidwa kupatsa mankhwala osapitirira mphindi 15 musanadye kapena mutatha kudya. Njira yoyendetsera ntchito ndi payokha. Pochita izi, kutentha kwa mankhwala akhale pamalo oyenera.

Zofunikira zatsiku ndi tsiku zimatha zosiyanasiyana, mpaka nthawi zambiri zimakhala 0.5-1 IU / kg. Mtsogolomo, tsiku ndi tsiku Mlingo umodzi wa mankhwalawo umasinthidwa malinga ndi momwe wodwala amagwirira ntchito ndi zambiri kuchokera ku mayeso angapo a magazi ndi mkodzo wa glucose.

Intravenous management ya Humalog imachitika ngati muyezo wa jekeseni wovomerezeka. Jakisoni wotsekemera amapangidwa m'apewa, matako, ntchafu kapena pamimba, nthawi ndi nthawi kuwasinthana osaloleza kugwiritsa ntchito malo amodzimodzi kamodzi pamwezi, ndipo malo omwe jakisoniyo sayenera kutenthedwa. Pakati pa njirayi, chisamaliro chimayenera kutengedwa kuti musalowe mumtsempha wamagazi.

Wodwala ayenera kuphunzira njira yolondola ya jakisoni.

Bongo

Mankhwala osokoneza bongo amatha kuyambitsa hypoglycemiaNdikuphatikizidwa ndi zoopsa, thukuta, kusanza, mphwayikunjenjemera, kusokonezeka kwa chikumbumtima, tachycardiamutu. Nthawi yomweyo, hypoglycemia imatha kuchitika osagwiritsa ntchito mankhwala osokoneza bongo okha, komanso zotsatira zake kuchuluka kwa insulinchifukwa cha mphamvu yamagetsi kapena kudya. Kutengera kuuma kwa hypoglycemia, njira zoyenera zimatengedwa.

Kuchita

Hypoglycemic zotsatira za mankhwala amachepetsa, mankhwala mahomoni a chithokomiro, GKS, beta 2-adrenergic agonists, tridclic antidepressants, okodzetsa, Diazoxide,, zochokera phenothiazine, nicotinic acid.

Hypoglycemic zotsatira za mankhwalawa zimatheka anabolic steroids, opanga betamankhwala okhala ndi Mowa Fenfluramine, manzeru, Guanethidine, Mao zoletsa, m`kamwa hypoglycemic mankhwala, salicylates, sulfonamides, ACE zoletsa, .

Malonda ogulitsa

Malo osungira

Musazizire m'firiji pa kutentha kwa 2 ° mpaka 8 ° C.

Tsiku lotha ntchito

Kufanana kwa code ya ATX Level 4:

Farmasulin, Inutral HM, Intral SPP, Iletin II wokhazikika, Iletin ndimakhazikika.

Ndemanga za Humalog

Ndemanga nthawi zambiri zimakhala zabwino. Zimathandizira kulipirira kusowa kwa shuga m'magazi. Pali maumboni ochepa owonetsa mavuto.

Mtengo wa Halogen, kuti mugule

Mtengo wa Humalog 100 IU / ml makatiriji 3 ml N5 amasiyana pamitundu yama ruble 1730-2086 phukusi lililonse. Mutha kugula mankhwalawa m'masitolo ambiri ku Moscow ndi m'mizinda ina.

• Mankhwala Ogulitsa Pa intaneti ku Russia
• Mankhwala apulogalamu apakompyuta Ukraine Ukraine
• Mankhwala ogulitsa pa intaneti ku Kazakhstan Kazakhstan

Humalog Mix25 yankho 100 IU / ml katiriji 3 ml 5 ma PC.

Humalog Mix25 kuyimitsidwa kwa 100 IU / ml mu cholembera cha Quick Pen syringe 3 ml 5 ma PC. Lilly Eli Lilly & Kampani

Humalog jakisoni 100ME / ml katiriji 3 ml 5 ma PC. Lilly Eli Lilly & Kampani

Dongosolo la Pharmacy * kuchotsera 100 rub. ndi njira yotsatsira pambali (zolamula kuchokera 1000 rub.)

Humalog Mix 50 makatoni. ndi syringe cholembera 100ME / ml 3ml QuickPen No. 5

Humalog Mix 50: malangizo ogwiritsa ntchito ndi kuwunikira

Humalog Mix 50 ndi mankhwala osokoneza bongo a hypoglycemic okhala ndi kuphatikiza kwapafupifupi komanso kwapakati pakhale insulin.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - kuyimitsidwa kwa kayendetsedwe ka kayendedwe kakang'ono: mtundu woyera, wokhazikika ndi mapangidwe otseguka komanso owoneka bwino, pafupifupi opanda maonekedwe kapena owoneka bwino, amasinthidwa mwachangu ndi kugwedeza modekha (3 ml mu cartridge, makatoni 5 mu chithuza, pakatoni yolongedza 1 chithuza, 3 ml pakatoni wopangidwa ndi cholembera cha syringe ya Quick Pen, mumakatoni a ma syringe 5, paketi iliyonse ilinso ndi malangizo ogwiritsira ntchito Humalog Remix 50).

Muli 1 ml ya kuyimitsidwa:

• yogwira mankhwala: insulin lispro - 100 International mayunitsi (ME),
• zothandizira: sodium hydrogen phosphate heptahydrate, protamine sulfate, phenol fluid, glycerol (glycerin), metacresol, zinc oxide, 10% sodium hydroxide solution ndi / kapena 10% hydrochloric acid solution, madzi a jekeseni.

Mankhwala

Mankhwala

Humalog Mix 50 ndi msanganizo wopangidwa wokonzeka wokhala ndi 50% yankho la lyspro insulin (analog yothamanga ya insulin yaumunthu) ndi kuyimitsidwa kwa 50% ya protamine kuyimitsidwa kwa inspro insulin (njira yapakatikati ya insulin analog).

Katundu wamkulu wa mankhwalawa ndi kukhazikitsidwa kwa kagayidwe ka glucose. Ilinso ndi zotsutsa-catabolic komanso anabolic zotsatira zosiyanasiyana za thupi. Mu minofu yamatenda motsogozedwa ndi Humalog Remix 50, zomwe zimakhala ndimafuta, glycerol ndi glycogen, kuphatikiza mapuloteni kumalimbikitsidwa, ndipo kumwa ma amino acid kumakulitsidwa. Izi zimachepetsa glycogenolysis, gluconeogeneis, lipolysis, ketogenesis, mapuloteni catabolism ndi kutulutsidwa kwa ma amino acid.

Zakhazikitsidwa kuti insulin lyspro imakhala ndi molarity wofanana ndi insulin yaumunthu, koma zotsatira zake zimakula mwachangu komanso zimakhala zochepa.

Pambuyo pakhungu pansi pa khungu, kuyambika kwa msambo wa lyspro insulin ndi kuyamba kwake kwa pachimake. Humalog Remix 50 imayamba kugwira ntchito pafupifupi mphindi 15 pambuyo pa kubayidwa, kotero imatha kutumikiridwa musanadye (mu mphindi 0 mpaka 15), mosiyana ndi insulin wamba.

Mbiri ya insulin lysproprotamine imafanana ndi mbiri ya insulin isofan yotalika pafupifupi maola 15.

Pharmacokinetics

Pharmacokinetics ya Humalog Remix 50 imatsimikiziridwa ndi mphamvu ya pharmacokinetic yazinthu zake ziwiri zogwira ntchito.

Kuchuluka kwa mayamwa ndi kuyambika kwa mankhwala kumadalira malo oyimitsidwa (ntchafu, pamimba, matako) ndi mlingo wake, komanso pazochitika zolimbitsa thupi za wodwalayo, kutentha kwake kwa thupi ndi magazi.

Lyspro insulin pambuyo subcutaneous makonzedwe mofulumira odzipereka. Kuchuluka kwa ndende m'magazi kumafika pambuyo pa mphindi 30-70.

Ma paracokinetic magawo a lysproprotamine insulin ndi ofanana ndi isofan insulin (sing'anga-insulin).

Mwa kuperewera kwa impso ndi kwa hepatic, inshuwaransi ya lyspro imayamwa mwachangu kwambiri kuposa insulin yaumunthu.

Zizindikiro zogwiritsidwa ntchito

Humalog Remix 50 imagwiritsidwa ntchito pa matenda a shuga omwe amafunikira chithandizo cha insulin.

Humalog Sakanizani 50, malangizo ogwiritsira ntchito: njira ndi mlingo

Humalog Mix 50 idapangidwa kuti ikwaniritse makina oyang'anira okha. Mutha kulowa nawo musanadye kapena musanadye. Mlingowo umatsimikiziridwa ndi dokotala aliyense payekha kwa wodwala aliyense, potengera kuchuluka kwa shuga m'magazi.

Mutha kulowa mankhwalawa pamimba, ntchafu, phewa kapena matako. Masamba obayira ayenera kusinthidwa kuti, pamalo omwewo, kuyimitsidwa ndikuyenera, ngati kungatheke, osaperekanso kamodzi pamwezi.

Mukamayambitsa Humalog Mix 50, chisamaliro chiyenera kutengedwa kuti aletse kuyimitsidwa kulowa mitsempha yamagazi. Palibenso chifukwa chokwanira kupukusa jekeseni pambuyo pa jekeseni.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zimadziwika kwambiri ndi mitundu yonse ya insulin ndi hypoglycemia. Milandu yayikulu, imatha kuyambitsa chikumbumtima, pokha pokha - imayambitsa imfa.

Nthawi zina thupi lanu siligwirizana: redness, kuyabwa, kapena kutupa pamalo a jakisoni. Monga lamulo, zochitika izi zimadalira palokha patatha masiku angapo / masabata. Mwa wodwala payekhapayekha, samagwirizanitsidwa ndi insulin, koma amayambitsidwa, mwachitsanzo, popanda kuyamwa kwa mankhwala kapena pakhungu pakatha kugwiritsa ntchito mankhwala oyeretsa.

Insulin nthawi zambiri imayambitsa zochitika zonse zamatsenga, koma zimakhala zazikulu kwambiri. Zizindikiro zotsatirazi zitha kuwoneka: kupuma movutikira, kupuma movutikira, kuchepa kwa magazi, tachycardia, kutuluka thukuta, pruritus. Ngati thupi lanu siligwirizana kwambiri, muyenera kuchitapo kanthu mwachangu. Odwala oterowo angafunike kufooka kwa mankhwala kapena kusintha kwa insulin.

Ndi chithandizo chotenga nthawi yayitali, lipodystrophy imatha kupezeka pamalo a jekeseni.

Milandu yapadera yokhudzana ndi chitukuko cha edema imadziwika, makamaka ndi kufalikira kwamisempha ya magazi motsutsana ndi maziko a insulin Therapy poyambira osakhutiritsa glycemic control.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Ndi chitukuko cha hypoglycemia, kuchepa kwamphamvu kwa magwiridwe antchito ndi chidwi kwambiri ndizotheka, zomwe zimawonjezera chiopsezo chovulala mukamachita zinthu zoopsa, kuphatikizapo kuyendetsa galimoto komanso kugwira ntchito ndi magawo ena. Pankhaniyi, kusamala kuyenera kuchitika, makamaka kwa odwala omwe zizindikiro za okhazikika za hypoglycemia palibe kapena ofatsa. Pankhani yakukhazikika kwa hypoglycemia, kuthekera kochita zinthu zomwe zingachitike ndi zoopsa kuyenera kuyesedwa.

Ndi chiwindi ntchito

Pankhani ya kulephera kwa chiwindi, Humalog Remix 50 iyenera kugwiritsidwa ntchito mosamala, moyang'aniridwa ndi dokotala, chifukwa kufunika kwa insulin kumatha kuchepa chifukwa kuchepa kwa kuthekera kwa gluconeogeneis komanso kuchepa kwa insulin metabolism. Komabe, kulephera kwa chiwindi, kuwonjezeka kwa insulin kungatheke, komwe kumafunikira kuchuluka kwa mlingo.

Kuyanjana kwa mankhwala osokoneza bongo

Zotsatira za hypoglycemic za Humalog Remix 50 zimachepetsedwa ndi beta 2 - adrenergic agonists (mwachitsanzo, terbutaline, salbutamol, ritodrin), glucocorticosteroids, phenothiazine zotumphukira, thiazide diuretics, iodine wokhala ndi chithokomiro cha mahomoni, contracepatives, nicotinazide, isacotoleaz, isacotoleaz, isacotoleaz, isacotoleaz, isacotole.

Hypoglycemic kanthu Humalog Mix 50 kumapangitsanso m'kamwa wothandizila hypoglycemic, mankhwala a sulfa mankhwala anabolic mankhwala, beta-blockers, angiotensin akatembenuka zoletsa enzyme (captopril, enalapril), angiotensin II cholandilira muzikangana, ena antidepressants (monoamine oxidase zoletsa), salicylates (mwachitsanzo, acetylsalicylic acid), tetracyclines , ethanol ndi ethanol-okonzekera, octreotide, guanethidine, fenfluramine.

Pogwiritsa ntchito munthawi yomweyo mankhwala a gulu la thiazolidinedione, chiopsezo chowonjezeka cha edema ndi kulephera kwa mtima ndizotheka, makamaka kwa odwala omwe ali ndi matenda amtima komanso kupezeka kwa zinthu zomwe zingayambitse matenda osalephera a mtima.

Reserpine, clonidine, ndi beta-blockers amatha kufinya zizindikiro za hypoglycemia zomwe zimapangidwa ndi Humalog Remix 50.

Kuchita kwa Humalog Mix 50 ndi insulin ina kukonzekera sikunaphunzire.

Kuthekera kwa kugwiritsa ntchito mankhwala ena aliwonse pachipatala cha matenda ashuga kuyenera kuvomerezedwa ndi dokotala.

Analogues Humalog Mix 50 ndi NovoMiks 30 Penfill, NovoMiks 30 FleksPen, NovoMiks 50 FleksPen, NovoMiks 70 FleksPen, kapamba aspart NovoRapid Penfill, NovoRapid FleksPen, Lantus SoloSTAR, Tudzheo SoloSTAR, Apidra, Homolong 40, insulin detemir, insulin lispro, Rosinsulin, Homorap 40 ndi ena.

Migwirizano ndi magwiritsidwe akusungidwa

Musayandikire ana, otetezedwa ku dzuwa ndi kutentha kwanyengo, kutentha kwa 2-8 ° C. Osamawuma. Zomwe zimagwiritsidwa ntchito zimatha kusungidwa kutentha mpaka 30 ° C, koma osapitirira masiku 28.

Moyo wa alumali ndi zaka zitatu.

Chinthu chofunikira kwambiri m'moyo wa munthu aliyense wodwala matenda ashuga ndi cholembera cha insulin. Kupanga kumeneku kumapangitsa moyo kukhala wosavuta kwa mamiliyoni a odwala padziko lonse lapansi. Kupatula apo, ngati cholembera choterocho chili pafupi, wodwalayo sayenera kupita kukathandizidwa ndi anamwino kuti apeze insulin yoyenera. Kulumpha kakang'ono kwambiri m'm shuga kungayambitse zovuta, kotero kugula jakisoni ndi gawo loyamba la moyo wathunthu.

Ndi mitundu yanji ya syringe yomwe ilipo?

Pankhani ya matenda a shuga, mapangidwe a metabolic amapezeka pang'onopang'ono m'thupi chifukwa cha kusakhazikika kwa kapangidwe ka insulin. Chithandizo cha matenda a shuga amtundu woyamba chimakhudzana ndi kuphatikiza kwa mahomoni. Mfuti ya syringe idapangidwa kuti ipangitse mankhwalawo kulowa mthupi mwadzidzidzi. Pali mitundu ingapo ya majakisoni:

• Syringe yochokera pa singano yochotsa. Chodabwitsa pakugwirira ntchito kwa cholembera ndikuti nthawi iliyonse yomwe wodwala akufunika kuyika singano yatsopano musanamwe mankhwala ndikuwapatsa.
• Syringe yomwe ili ndi singano yopangidwa. Chipangizo chamtunduwu chimadziwika kuti singano ili ndi dzina lotchedwa "zone zone", yomwe imachepetsa chiopsezo chotaya insulini.

Kodi mungasankhe bwanji cholembera cha insulin?

Mfuti iliyonse ya insulin ya odwala matenda ashuga amapangidwa kuti ikwaniritse zofunikira zonse za odwala omwe ali ndi matenda ashuga. Piston ya chogwirira iyenera kupangidwa m'njira yoti ikhale yosavuta kugwiritsa ntchito jakisoni popanda kumva kuwawa. Mukamagula syringe ya insulini, ndikofunikira kuti mupereke chidwi ndi kuchuluka kwa chipangizocho. Muyenera kusankha nyali ya syringe yolemetsa, yokhala ndi chizindikiro chomveka chomwe chimaperekedwa pomwe mahomoni ali ndi jekeseni.

Dokotala amasankha kuchuluka kwa mankhwalawa, nthawi zambiri amakhala ndi mayunitsi a 0,5 kwa ana, ndi 1 unit kwa akuluakulu.

"Protafan NM Penfil"

Kugwiritsa ntchito kumaloledwa pokhapokha pobayira jekeseni, sikuletsedwa kulowa mkati. Ndikulimbikitsidwa kuti musinthe jakisoni nthawi iliyonse. Kuyimitsidwa kumawerengeredwa ngati gulu la insulin lomwe limakhala ndi nthawi yayitali yochitapo kanthu. Wopezeka m'makatoreji 5. Mukatha kugwiritsa ntchito Protafan, ndikofunikira kuonetsetsa kuti singanoyo imachotsedwa mu syringe. Kupanda kutero, mankhwalawa amatha kutayikira, zomwe zimakhala zowopsa ndikusintha kwake.

Rinsulin R

Kukonzekera kwa Rinsulin NPH kumapangidwira magwiridwe osinthika. Simungachulukitse mankhwalawa ngati adayamba kuzizira. Pezani thunthu ndi kaphatikizidwe, limakhala ndi nthawi yochepa yochitapo kanthu. Yogwiritsidwa ntchito ndi chida cha RinAstra. Imagwira ntchito pokhapokha ngati chinthucho chafikira kutentha m'chipinda.

"Let Carry-N Royal"

Kuti muthandizire insulin, mumafunikira Wozulim pen Royal insulin. Mankhwalawa amaphatikiza insulin yapakatikati komanso yochepa. Ndikulimbikitsidwa kuti musamale ndi odwala omwe ali ndi matenda a impso. Itha kugwiritsidwa ntchito pa nthawi yoyembekezera, mankhwalawa sawoloka placenta. Kutalika kwa kuyimitsidwa ndi maola 24.

Rosinsulin

Cholembera chosinthanso "Rosinsulin Comfort cholembera" chili ndi pulasitiki yopepuka. Wogwiritsa ntchito amatha kusintha mlingo, chipangizocho chimaphatikizapo gudumu lofewa la zida. Chipangizocho chili ndi magawano omveka bwino mpaka 60. Zothandiza kwa anthu omwe ali ndi vuto lowona. Cholembera chachitsime chidapangidwa kuti chigwiritsidwe ntchito kambiri ndi kuthekera kosintha katiriji. Pali mwayi woti musinthe mtundu woyipa wolakwika. Kuphatikizanso ndi malangizo.

BiomaticPen

Chogwirira chimasiyana ndi ena opanga omwe amaponyedwa mosavuta ndi singano yopyapyala, yomwe imachepetsa ululu pang'ono. "BiomaticPen" ndiyoyenera, yomwe ingagulidwe mu shopu yapadera kapena pa intaneti. Chipangizocho chimakhala ndi pulogalamu yowonetsera pakompyuta yomwe imawonetsa kuchuluka kwa mankhwalawa. Musanalowe mu "Biosulin", muyenera kuwerenga malangizowo.

HumaPen Savvio

Syringe cholembera "Humapen Savvio" amapangidwira kuti asamapatsidwe shuga komanso matenda ashuga. Chochititsa chidwi ndi kapangidwe ka jakisoni. Chipangizocho chimapangidwa ndi aluminiyumu, chosagwirizana ndi kuwonongeka kwa makina ndikakanda pamlandu. Chomaliza ndi kesi chimabwera thumba lomwe limatha kukhala ndi singano 6. Imapezeka mumitundu ingapo. Okonzeka ndi makina ochotsera mawotchi komanso chida chodziimira pakamwa.

Autopen classic

Autopen Classic reusable insulin mfuti imagwirizana ndi mitundu ingapo ya insulin, monga Biosulin, Rosinsulin ndi ena. Chipangizo cha Avtopen chitha kugwiritsidwanso ntchito ndi singano zonse zamtundu. Cholembera cha syringe ya Autopen chimaphatikizapo: chosakanizira cha dispenser, kesi yofewa, singano 3 zosalala (8 mm) ndi chipangacho chokha. Ndikulimbikitsidwa kuti muwerenge malangizo musanayambe kugwiritsa ntchito.

Kuwoneka kwa mfuti za insulin kunapangitsa kuti moyo ukhale wosavuta kwa anthu odwala matenda ashuga, ndipo zolembera za SoloStar syringe sizili choncho. Izi ndi zinthu zotayika za insulin. Amapangidwa kuti azigwiritsa ntchito nokha, kupewa ngozi yotenga kachilomboka. Jakisoni aliyense amafunika kugwiritsa ntchito singano yatsopano, yomwe iyenera kuyikidwedwa isanayambike insulin. Mukatha kugwiritsa ntchito, chogwiracho chimatsekedwa ndi chipewa, singano imachotsedwa kaye. Amagwiritsidwa ntchito ndi insulin "Insuman Comb 25".

Humulin Mwachangu

Peni ya syringe ya QuickPen siili yotsika mtengo potchuka kwa opanga ena. Oyenera amayi apakati omwe ali ndi matenda ashuga a 2. Autopen classic syringe cholembera ndi Humulin Rapid ndi atsogoleri amsika. Mosiyana ndi njira yoyamba, chida cha QuickPen ndichotaya, ndikuthira. Ntchito iliyonse ya Humulin, chida chitatayidwa, pensulo imayenera kusinthidwa. Bokosi limaphatikizapo 5 zolembera 3 ml ya yankho lililonse.

Mankhwala

The pharmacokinetics ya lyspro insulin imawonetsedwa ndi kuyamwa mwachangu ndi kukwera m'magazi pambuyo pa 30 - 70 mphindi pambuyo povulaza subcutaneous. Lyspro insulin imayamba mwachangu (pafupifupi mphindi 15 pambuyo pobayidwa jakisoni), yomwe imalola kuti mankhwalawo aperekedwe nthawi yomweyo musanadye chakudya . Lyspro insulin imakhala ndi nthawi yofupikirako (maola 2 mpaka 5) poyerekeza ndi insulin ya anthu wamba.

Kutalika kwa nthawi ya insulin lispro kumatha kukhala kosiyanasiyana mwa odwala kapena nthawi zosiyanasiyana wodwala yemweyo ndipo zimatengera mlingo, malo opangira jakisoni, magazi, kutentha kwa thupi ndi zochitika zolimbitsa thupi.

Insulin ikalowetsedwa, lyspro imawonetsa kuyamwa mwachangu poyerekeza ndi insulin yaumunthu mwa odwala omwe ali ndi impso ndi hepatic, komanso kuchotsedwa kwachangu kwa odwala omwe ali ndi hepatic insufficiency. Odwala omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo omwe ali ndi vuto laimpso losiyanasiyana, kusiyana kwa pharmacokinetic pakati pa lyspro insulin ndi insulin yocheperako nthawi zambiri kumakhala kulimba ndipo samadalira kuwonongeka kwa aimpso.

Kuyankha kwa glucodynamic ku lyspro insulin sikudalira kugwira ntchito kwa chiwindi ndi impso.

Lyspro insulin adawonetsedwa kuti ndiofanana ndi insulin yaumunthu, koma zochita zake zimachitika mwachangu kwambiri ndikukhalitsa kwakanthawi.

Lyspro insulin ndi analogue ya DNA yomwe imapanganso insulin ya anthu. Amasiyana ndi insulin yaumunthu mu kusintha kwama amino acid m'malo 28 ndi 29 a insulin B.

Chochita chachikulu cha insulin lyspro ndi malamulo a kagayidwe ka glucose. Kuphatikiza apo, imakhala ndi anabolic komanso anti-catabolic zotsatira zosiyanasiyana zamthupi. Mu minofu ya minofu, pali kuchuluka kwa glycogen, mafuta acid, glycerol, kuchuluka kwa mapuloteni komanso kuwonjezereka kwa kumwa ma amino acid, koma nthawi yomweyo kumachepa mu glycogenolysis, gluconeogeneis, ketogenesis, lipolysis, proteinabolism ndi kutulutsidwa kwa ma amino acid.

Mbiri ya pharmacodynamic ya insulin lyspro mwa ana ndiofanana ndi akulu.

Zambiri ndi mankhwala a pharmacological

Humalog ili mu mawonekedwe a kuyimitsidwa kapena jakisoni. Kuyimitsidwa kumakhala koyera komanso kutengera kupangika. Njira yothetsera vutoli ndi yopanda utoto komanso wopanda fungo, yowonekera.

Chofunikira kwambiri pakuphatikizidwacho ndi insulin.

Kuphatikiza apo, zosakaniza monga:

• madzi
• metacresol
• zinc oxide
• glycerol
• sodium hydrogen phosphate heptahydrate,
• sodium hydroxide solution.

Chogulitsachi chimagulitsidwa m'mak cartridge atatu. Makatoni ali ku Quicken, zidutswa 5 pa paketi iliyonse.

Komanso pali mitundu ya mankhwalawa, yomwe imaphatikizapo yankho la insulin yochepa komanso kuyimitsidwa kwa protamine. Amadziwika kuti Humalog Remix 25 ndi Humalog Remix 50.

Insulin Lizpro ndi analogue ndipo amadziwika ndi zomwezo. Zimathandizira kukulitsa kuchuluka kwa shuga. Pulogalamu yogwira imagwira pama cell membrane, chifukwa choti shuga kuchokera m'magazi amalowa m'matumbo ndipo amawagawa. Zimathandizanso kupanga mapuloteni omwe amagwira ntchito.

Mankhwala amadziwika ndi kuchitapo kanthu mwachangu. Zotsatira zimawonekera mkati mwa kotala la ola mutatha jakisoni. Koma imapitilira kwakanthawi. Hafu ya moyo wa zinthu zimafunika pafupifupi 2 hours. Nthawi yowonetsera kwambiri ndi maola 5, omwe amathandizidwa ndi mawonekedwe a thupi la wodwalayo.

Zizindikiro ndi contraindication

Chizindikiro chogwiritsira ntchito mankhwala omwe ali ndi insulin ndi:

• (pamaso pa tsankho la mitundu ina ya insulin),
• (ngati mankhwala ndi mankhwala ena sangathandize)
• anakonzekera kuchitapo kanthu opaleshoni

Muzochitika izi, mankhwala a insulin amafunikira. Koma Humalog iyenera kusankhidwa ndi adotolo atatha kuphunzira chithunzi cha matendawa. Mankhwalawa ali ndi zotsutsana zina. Muyenera kuwonetsetsa kuti kulibe, apo ayi pamakhala zovuta za zovuta.

Izi zikuphatikiza:

• mwadzidzidzi (kapena mwina mwadzidzidzi)
• ziwengo kuti zikuchokera.

Ndi izi, adotolo ayenera kusankha mtundu wina wa mankhwala.Kusamala ndikofunikanso ngati wodwala ali ndi matenda ena owonjezereka (matenda a chiwindi ndi impso), chifukwa chifukwa cha iwo, kufunikira kwa insulin kumatha kufooka. Chifukwa chake, odwala otere ayenera kusintha mlingo wa mankhwalawa.

Odwala Apadera ndi Mayendedwe

Mukamagwiritsa ntchito Humalog, kusamala kwina kumafunikira pokhudzana ndi magulu apadera a odwala. Matupi awo amatha kukhala osamala kwambiri ndi zovuta za insulin, motero muyenera kukhala anzeru.

Zina mwa izo ndi:

1. Amayi pa nthawi yoyembekezera. Mwachidziwitso, chithandizo cha matenda a shuga mwa odwala amaloledwa. Malinga ndi zotsatira za kafukufuku, mankhwalawa samavulaza kukula kwa mwana wosabadwayo ndipo samayambitsa mimbayo. Koma ziyenera kukumbukiridwa kuti munthawi imeneyi kuchuluka kwa shuga m'magazi kumatha kukhala kosiyana panthawi zosiyanasiyana. Izi ziyenera kuyang'aniridwa kuti mupewe zotsatira zoyipa.
2. Amayi oyamwitsa. Kulowetsedwa kwa insulin mkaka wa m'mawere sikowopsa kwa akhanda. Izi zimachokera kumapuloteni ndipo zimatengedwa m'matumbo a mwana. Chenjezo lokha ndiloti azimayi omwe amadyetsa mwachilengedwe ayenera kudya.

Kwa ana ndi okalamba posakhala ndi mavuto azaumoyo, chisamaliro chapadera sichofunikira. Humalog ndi yoyenera chithandizo chawo, ndipo adotolo ayenera kusankha kuchuluka kwa mankhwalawa kutengera mawonekedwe a matendawa.

Kugwiritsa ntchito Humalog kumafunikira kukonzekereratu poyerekeza ndi matenda ena oyipa.

Izi zikuphatikiza:

1. Kuphwanya chiwindi. Ngati chiwalochi chikugwira ntchito moyipa kuposa momwe chikufunikira, ndiye kuti mankhwalawo atha kukhala ochulukirapo, zomwe zimabweretsa zovuta, komanso kukula kwa hypoglycemia. Chifukwa chake, pakakhala kulephera kwa chiwindi, mlingo wa Humalog uyenera kuchepetsedwa.
2. Mavuto a impso. Ngati alipo, palinso kuchepa kwa kufunika kwa insulin. Pankhaniyi, muyenera kuwerengera mosamala ndi kuyang'anira njira yochiritsira. Kukhalapo kwa vuto lotere kumafuna kupenda kwakanthawi.

Humalog imatha kuyambitsa hypoglycemia, chifukwa chomwe kuthamanga kwazomwe zimachitika komanso kuthekera kwazomwe zimayang'ana zimasokonezedwa.

Chizungulire, kufooka, kusokonezeka - zinthu zonsezi zimatha kugwira ntchito kwa wodwala. Zochita zomwe zimafunikira kuthamanga komanso kusokonezedwa zimatha kukhala zosatheka kwa iye. Koma mankhwalawo pawokha samakhudza izi.

Mikhalidwe yapadera

Kusamutsa wodwala kupita ku mtundu wina kapena mtundu wa insulin kuyenera kuchitika moyang'aniridwa ndi achipatala. Kusintha kwa zochitika, mtundu (wopanga), mtundu (mwachitsanzo, Wokhazikika, NPH, Tepi), mitundu (nyama, anthu, ma insulin analogue) ndi / kapena njira yopanga (DNA recombinant insulin kapena insulini yachikhalidwe) ingafunike kusintha kwa mlingo.

Mikhalidwe yomwe zizindikiro zoyambirira za hypoglycemia zitha kukhala zopanda tanthauzo komanso zocheperako zimaphatikizira matenda a shuga, kupatsirana kwa insulin, matenda amanjenje matenda a shuga, kapena mankhwala, monga beta-blockers.

Odwala omwe ali ndi vuto la hypoglycemic atasamutsidwa kuchokera ku insulin yochokera ku nyama kupita ku insulin yaumunthu, zizindikiro zoyambirira za hypoglycemia zitha kutchulidwa pang'ono kapena zosiyana ndi zomwe adakumana nazo kale ndi insulin. Hypoglycemic yosasinthika kapena ma hyperglycemic zomwe zimachitika zimatha kuyambitsa chikumbumtima, chikomokere, kapena kufa.

Mlingo wosakwanira kapena kutha kwa mankhwalawo, makamaka ndi matenda a shuga a shuga, amatha kutsegula ndi hyperglycemia ndi matenda ashuga a ketoacidosis, mikhalidwe yomwe ikhoza kukhala pangozi kwa wodwalayo.

Kufunika kwa insulini kumatha kuchepa kwa odwala omwe amalephera kupweteka kwa impso, komanso kwa odwala omwe ali ndi vuto la chiwindi chifukwa cha kuchepa kwa machitidwe a gluconeogeneis ndi insulin metabolism. Komabe, mwa odwala omwe ali ndi vuto losatha la chiwindi, kukana kwa insulini kungayambitse kuchuluka kwa insulin.

Kufunika kwa insulin kumatha kuwonjezeka ndi matenda opatsirana, kupsinjika kwamalingaliro, ndikuwonjezereka kwa kuchuluka kwa chakudya chamagulu muzakudya.

Kusintha kwa mlingo kungafunikenso ngati wodwala akucita zolimbitsa thupi kapena ngati zakudya zabwinobwino zasintha. Kuchita masewera olimbitsa thupi mukangomaliza kudya kumawonjezera chiopsezo cha hypoglycemia. Zotsatira za pharmacodynamics za insulin analogi zomwe zimagwira mwachangu ndikuti ngati hypoglycemia imayamba, ndiye kuti imatha kupanga jekeseni m'mbuyomu kuposa kubayidwa insulin yamunthu.

Wodwalayo ayenera kuchenjezedwa kuti ngati dokotala atayambitsa kukonzekera kwa insulin ndi 40 IU / ml mu vial, ndiye kuti insulini sayenera kutengedwa kuchokera ku cartridge ndi insulin ya 100 IU / ml pogwiritsa ntchito syringe pobayira insulin ndi kuchuluka kwa 40 IU / ml.

Ngati ndi kotheka, imwani mankhwala ena nthawi yomweyo ndi mankhwalawo

Shuga mellitus mwa akulu ndi ana, omwe amafunikira chithandizo cha insulin kuti akhalebe ndi shuga.

Kufotokozera kwa Insulin Humalog

Insulin Humalog Yachidule imapangidwa ndi kampani yaku France ya Lilly France, ndipo mawonekedwe ake otulutsidwa ndi njira yosavuta komanso yopanda utoto, yokhazikitsidwa ndi kapisolo kapena cartridge. Zotsalazo zitha kugulitsidwa zonse ngati gawo la syringe yokonzedwa kale, kapena padera magawo asanu pa 3 ml pachimake. Monga njira ina, makonzedwe angapo a Humalog Mix amapangidwa mwa kuyimitsidwa kwa kayendetsedwe koyenda, pomwe Humalog Remix imatha kutumikiridwa kudzera m'mitsetse.

Chofunikira chachikulu cha Humalog ndi insulin lispro - mankhwala a magawo awiri pa 100 IU pa 1 ml ya yankho, zomwe zimayendetsedwa ndi izi:

• glycerol
• metacresol
• zinc oxide
• sodium hydrogen phosphate heptahydrate,
• hydrochloric acid solution,
• sodium hydroxide solution.

Kuchokera pakuwona kwa gulu lazachipatala ndi zamankhwala, Humalog amatanthauza kufananizira kwa insulin yaumunthu yochepa, koma imasiyana ndi iwo m'njira zotsatizana zingapo za ma amino acid. Ntchito yayikulu ya mankhwalawa ndikuyang'anira kuyamwa kwa shuga, ngakhale ilinso ndi mphamvu ya anabolic. Pharmacologically, imachita motere: kuwonjezeka kwa glycogen, mafuta acids ndi glycerol amalimbikitsidwa minofu minofu, komanso kuwonjezeka kwa kuchuluka kwa mapuloteni komanso kumwa kwa amino acid ndi thupi. Mofananamo, njira monga glycogenolysis, gluconeogeneis, lipolysis, mapuloteni catabolism, ndi ketogeneis zimayamba kuchepa.

Kafukufuku wasonyeza kuti mwa odwala omwe ali ndi mitundu yonse ya shuga m'matumbo atatha kudya, kuchuluka kwa shuga kumachepa kwambiri ngati Humalog imagwiritsidwa ntchito m'malo mwa insulin ina yosungunuka.

Ndikofunika kukumbukira kuti ngati wodwala yemwe ali ndi matenda ashuga nthawi yomweyo amalandira insulin yochepa komanso basal insulin, ndikofunikira kusintha mlingo wa mankhwala oyamba ndi achiwiri kuti mukhale ndi zotsatira zabwino. Ngakhale kuti Humalog ndi ya ma insulin osakhalitsa, nthawi yotsiriza yochita zake imatsimikizidwa ndi zinthu zingapo payekhapayekha kwa wodwala aliyense.

• Mlingo
• tsamba la jakisoni
• kutentha kwa thupi
• zolimbitsa thupi
• mtundu wamagazi.

Payokha, ndikofunikira kudziwa kuti insulin Humalog imagwira ntchito mofananamo pankhani ya odwala matenda ashuga komanso pa ana kapena achinyamata. Sichisinthike kuti kuchuluka kwa mankhwalawa sikudalira kupezeka kwa aimpso kapena kwa chiwindi, komanso kuphatikiza ndi kuchuluka kwa sulfonylurea, kuchuluka kwa hemoglobin ya glycated kumachepa kwambiri. Mwambiri, pakhala pali kuchepa kwakukulu kwa chiwerengero cha nocturnal hypoglycemia, pomwe odwala matenda ashuga nthawi zambiri amavutika ngati samamwa mankhwala oyenera.

Makhalidwe a Humalog insulin omwe akuwonetsedwa manambala amawoneka motere: kuyambika kwa mphindi 15 pambuyo pa jakisoni, nthawi yochitapo kanthu ikuchokera maola awiri mpaka asanu. Kumbali ina, kugwiritsa ntchito bwino mankhwalawa kumakhala kotsika poyerekeza ndi komwe kumachitika panjira, ndipo winayo amatha kugwiritsidwa ntchito mphindi 15 asanadye, osati 30-31, monga momwe zimakhalira ndi ma insulini ena.

Migwirizano ndi magwiritsidwe akusungidwa

Humalog iyenera kusungidwa m'malo osavomerezeka ndi ana mkati mwa firiji wamba, kutentha kwa +2 mpaka +8 digiri Celsius. Moyo wa alumali wamba ndi zaka ziwiri. Ngati phukusi latsegulidwa kale, insulini iyi iyenera kusungidwa kutentha kutentha +15 mpaka +25 Celsius.

Chisamaliro chikuyenera kuthandizidwa kuti mankhwalawa asatenthe komanso kuti alibe dzuwa. Mukayamba kuyamba kugwiritsa ntchito, moyo wa alumali umachepetsedwa kukhala masiku 28.

Zofananira mwachindunji za Humalog zikuyenera kuwonedwa ngati kukonzekera konse kwa insulin kumathandizanso odwala matenda ashuga chimodzimodzi. Mwa zina mwazotchuka kwambiri ndi Actrapid, Vosulin, Gensulin, Insugen, Insular, Humodar, Isofan, Protafan ndi Homolong.

MALANGIZO OGULITSIRA NTCHITO MIYANI

Dzinalo Lopanda Padziko Lonse

Jekeseni 100 IU / ml 3 ml

1 ml yankho lili

yogwira mankhwala - insulin lispro 100 IU / ml,

zotuluka: metacresol, glycerin, zinc oxide, sodium hydrogen phosphate, hydrochloric acid 10% kusintha pH, sodium hydroxide 10% yothetsera kusintha pH, madzi a jakisoni.

Madzi opanda mafuta

Mankhwala ochizira matenda ashuga. Insulin ndi ma analogi ochita zinthu mwachangu.

Nambala yazosinthira mafoni nambala A10AV04

Kukhazikika kwa lyspro insulin pambuyo pa subcutaneous makonzedwe ndi pafupifupi mphindi 15, pazofunikira kwambiri kuyambira 30 mpaka 70 mphindi, kutalika kwa zochita kumachitika kuyambira maola 2 mpaka 5. Nthawi ya lyspro insulin ingasiyane kutengera mlingo, jakisoni malo, magazi, kutentha, zochitika zolimbitsa thupi ndi ena. Mwazi, lyspro insulin imamangirira ku alpha-beta globulins. Nthawi zambiri, kumangiriza kumangokhala 5-25%, koma kumatha kukula kwambiri pamaso pa ma antibodies a seramu omwe amawoneka munthawi ya chithandizo. Kuchulukitsa kwa kugawa kwa insulin lyspro ndikofanana ndi anthu ndipo kumakhala 0,26 - 0,36 l / kg. Lyspro insulin kagayidwe amapezeka m'chiwindi ndi impso. Mu chiwindi, pakumayenda magazi amodzi, mpaka 50% ya mlingo wochotseredwa sichitha, mu impso timadzi timadzi tomwe timasungidwa mu glomeruli ndikuwonongeka mu tubules (mpaka 30% ya mankhwala omwe akhazikika). Pansi pa 1.5% ya inshuwaransi ya lyspro imatulutsidwa mkodzo osasinthika. Hafu ya moyo ili pafupifupi ola limodzi.

Humalog ® ndi mawonekedwe a insulin yaumunthu ndipo amasiyana nayo pokhapokha potsatira kusintha kwa proline ndi lysine amino acid zotsalira pamalo 28 ndi 29 a insulin B. Chochita chachikulu cha Humalog® ndikuwongolera kwa kagayidwe ka glucose. Kuphatikiza apo, ma insulin onse ali ndi zotsatira zosiyana za anabolic komanso anti-catabolic pamitundu yambiri ya thupi. Mu minofu yamatenda ndi minyewa ina (kupatula ubongo), Humalog ® imathandizira kuyendetsa mwachangu ma glucose ndi amino acid, imathandizira njira ya anabolic komanso imalepheretsa mapuloteni ena.Mu chiwindi, Humalog® imawonjezera kugulitsa kwa glucose ndi masitolo a glucose mu mawonekedwe a glycogen, amalepheretsa gluconeogeneis ndikuthandizira kusintha kwa glucose owonjezera kukhala mafuta. Kuyankha kwa glucodynamic ku Humalog® sikudziyimira pawokha kwa chiwindi ndi impso. Mankhwala a Humalog® mwa ana ndi ofanana ndi akulu.

Zizindikiro zogwiritsidwa ntchito

shuga mellitus mwa akulu ndi ana opitilira zaka 3, momwe mankhwala a insulin amasonyezedwera kuti azikhala ndi matenda a homeostasis

kukhazikika kwa matenda ashuga koyambira

Mlingo ndi makonzedwe

Mlingo wa Humalog® umatsimikiziridwa ndi dokotala kutengera mtundu wa wodwalayo. Kuzindikira kwa odwala kutuluka kwina insulin ndi kosiyana, 1 unit ya insulin yomwe imayang'aniridwa mosalekeza imalimbikitsa kuyamwa kwa 2 mpaka 5 g shuga. Humalog® imalimbikitsidwa kuti iperekedwe pasanadutse kuposa mphindi 15 musanadye kapena mutangotha ​​kudya kamodzi pa tsiku (monotherapy) kapena katatu patsiku limodzi ndi insulin. Mankhwala omwe atumizidwa ayenera kukhala otentha.

Njira yoyendetsera Humalog® mwa achikulire ndi ana ndi payekha! Mlingo umodzi komanso wa tsiku ndi tsiku umasinthidwa malinga ndi zotsatira za kubwereza kwa magazi m'magazi ndi mkodzo masana komanso kutengera zomwe zimafunikira wodwala.

Zosowa za tsiku ndi tsiku za Humalog® zimatha kusiyanasiyana, nthawi zambiri ndi 0.5-1.0 IU / kg / tsiku.

Kuwongolera kwapakati pa Humalog® kumachitika ngati jekeseni wovomerezeka wamkati. Kupanga kwamitsempha kwa Humalog® kumatha kuchitika kuwongolera kuchuluka kwa shuga m'magazi a ketoacidosis, matenda apakhungu, kapena pakuchita opaleshoni komanso nthawi ya postoperative. Poterepa, nthawi zambiri ndikofunikira kulamula kuchuluka kwa shuga m'magazi. Makina a kulowetsedwa ndi kuchuluka kwa 0.1 IU / ml ndi mpaka 1 IU / ml ya Humalog® mu 0,9% sodium kolorayidi kapena 5% dextrose amakhala okhazikika kutentha kwa chipinda kwa maola 48.

Potengera kulowetsedwa kwa Humalog® ndi pampu ya insulin, malangizo a pampu ayenera kutsatiridwa mosamalitsa. Njira ya kulowetsedwa imasinthidwa maola 48 aliwonse. Ngati hypoglycemia ikukula, kulowetsaku kumatha. Mukamagwiritsa ntchito pampu, Humalog® sayenera kusakanikirana ndi ma insulini ena.

Jakisoni wotsekemera amayenera kuperekedwa kwa mapewa, m'chiuno, matako kapena pamimba. Masamba a jakisoni amayenera kusinthidwa kuti malo omwewo sawagwiritsanso ntchito mwina kamodzi pamwezi. Mothandizidwa ndi hypodermic ya Humalog®, chisamaliro chimayenera kutengedwa kuti choteteza kulowa mu jakisoni. Pambuyo pa jakisoni, malo a jakisoni sayenera kutenthedwa .. Odwala ayenera kuphunzitsidwa njira yoyenera yoyendetsera insulin.

Ma cartridge a Humalog® safuna kupatsidwanso mphamvu ndipo akhoza kugwiritsidwa ntchito pokhapokha ngati zomwe zili bwino ndizopanda madzi, zopanda ma cell.

Osagwiritsa ntchito ngati ali ndi ma flakes. Ma kapangidwe ka makatoni amalola kuti zomwe zili mkati mwake zisakanikirane ndi ma insulin enanso mwachindunji mu cartridge palokha. Makatoniwo sanapangidwe kuti adzazitsidwe. Tsatirani malangizo a wopanga pa cholembera chilichonse mukadzaza makatoni, ndikulowa ndi singano, komanso jakisoni wa insulin.

Sankhani tsamba la jakisoni.

Pukuta khungu pamalo opukutira ndi thonje la thonje.

Chotsani kapu yakunja yoteteza ku singano.

Sinthani khungu lanu pokoka kapena kulikhomera kukhala khola lalikulu.

Ikani singano ndi jakisoni.

Chotsani singano ndikudikirira pang'ono malo a jekeseni kwa masekondi angapo. Osatupa malo a jakisoni.

Pogwiritsa ntchito singano yakunja, mutangoyambitsa mankhwalawo, gulani singano ndikuyipeza pamalo otetezeka.

Ndikofunikira kusinthana mawebusayiti enanso mwanjira yoti malo omwewo sagwiritsidwe ntchito kopitilira kamodzi pamwezi.

Osasakaniza yankho la insulini mu Mbale ndi insulin m'makalata.

Zotsatira zoyipa zomwe zidachitika nthawi zambiri kuposa zomwe zimachitika kamodzi zimalembedwa molingana ndi izi:: Nthawi zambiri (≥ 10%), nthawi zambiri (≥ 1%, 0,1%, 0,01%, Mutha kusunga shuga wokhazikika ngakhale ndi matenda oopsa a autoimmune. Ndipo makamaka, ndi matenda a shuga a 2 ochepa. Palibe chifukwa chakuwonjezera kuchuluka kwa shuga m'magazi anu kuti mudzilimbitse nokha motsutsana ndi hypoglycemia yoopsa. Onerani kanema yemwe akufotokoza nkhaniyi ndi bambo wa mwana yemwe ali ndi matenda ashuga 1. Phunzirani momwe mungasinthire zakudya zopatsa thanzi komanso mulingo wa insulin.

Mwazi wamagazi wanu ungakhale wabwino kwambiri ngati musinthira. Sizikupanga nzeru kwa odwala matenda ashuga omwe amatsata izi kuti awerenge chakudya m'magawo a mkate. Chifukwa kudya kwa tsiku ndi tsiku kwamakina osaposa 2,5 XE, komanso kwa ana ochepera.

Ponena za ana, ndizomveka kusinthira mwana wodwala matenda ashuga kuti akhale zakudya zamafuta ochepa, gwiritsani ntchito Actrapid kapena mankhwala ena achidule m'malo mwa Humalog insulin, komanso kukana kugwiritsa ntchito pampu ya insulin. Werengani nkhani "" kuti mumve zambiri.

Kodi zingakwanitse bwanji?

Humalog mwachangu kuposa mankhwala ena amatha kupangitsa kuti shuga azikhala kwambiri. Chifukwa chake, ndibwino kukhala nanu pokhapokha pachitika ngozi. Komabe, ochepa omwe ali ndi matenda ashuga omwe ali ofunitsitsa kugwiritsa ntchito onse aifupi ndi a insulin. Ngati muthana ndi kagayidwe kakang'ono ka shuga wanu wamafuta ochepa, mungathe kudutsa ndi mankhwala osakhalitsa.

Kodi jakisoni aliyense amatalika bwanji?

Jekeseni aliyense wa mankhwala a Humalog amatha pafupifupi maola anayi. Anthu odwala matenda ashuga omwe amatsata amafunika Mlingo wambiri wa insulin. Nthawi zambiri imayenera kuchepetsedwa kuti ipange jekeseni woyenera wa mankhwala osakwana 0,5-1. Humalog imatha kuchepetsedwa osati kwa ana omwe ali ndi matenda a shuga 1, komanso odwala akuluakulu. Chifukwa ndi mankhwala amphamvu kwambiri. Mukamagwiritsa ntchito mankhwala ochepa, insulin imasiya kugwira ntchito mwachangu kuposa momwe amafunidwira. Mwina jakisoni amatha kumapeto kwa maola awiri ndi awiri ndi awiri.

Pakapita jakisoni iliyonse ya kukonzekera kwa ultrashort, muyezetse magazi osachepera maola atatu pambuyo pake. Chifukwa kufikira nthawi ino, mlingo wa insulin wolandirira ulibe nthawi kuti uwonetse mphamvu yake yonse. Monga lamulo, anthu odwala matenda ashuga amapereka jakisoni wa insulin yofulumira, idyani, kenako kuyeza shuga kale chakudya chotsatira. Pokhapokha ngati wodwala akumva. Zikatero, muyenera kuyang'ana kuchuluka kwa shuga m'magazi ndipo ngati kuli koyenera, chitanipo kanthu.

Kodi pali kusiyana kotani pakati pa Humalog ndi Humalog Remix?

Prost proteni Hagedorn (NPH), yomwe imachepetsa zochita za insulin, yawonjezeredwa ku Humalog Remix 25 ndi 50. Mitundu ya insulin iyi imasiyana ndi zomwe zili mu NPH. Mowonjezereka mankhwala, kumawonjezera zochita za jakisoni. Mankhwalawa ndi otchuka chifukwa amatha kuchepetsa kuchuluka kwa jakisoni tsiku ndi tsiku, kuchepetsa njira ya insulin. Komabe, sangapereke magazi moyenera. Chifukwa chake, tsamba lawebusayiti silimbikitsa kugwiritsa ntchito kwawo.

Werengani za kupewa ndi kuchiza mavuto:

Ndi insulin iti yomwe ili bwino: Humalog kapena NovoRapid?

Pangakhale palibe chidziwitso cholondola choyankha funso ili, lomwe nthawi zambiri limafunsidwa ndi odwala. Chifukwa mitundu yambiri ya insulini imakhudza aliyense wodwala matenda ashuga payekhapayekha. Monga Humalog, ali ndi mafani ambiri. Monga lamulo, odwala amapaka jakisoni mankhwala omwe amapatsidwa kwaulere.

Ziwengo zimakakamiza ena kuti asinthe mtundu wina wa insulin kupita ku wina. Tikubwerezanso kuti, ngati tikuwonetsetsa kuti tikuyenda mwachangu musanadye, ndibwino kugwiritsa ntchito mankhwala achidule, mwachitsanzo, m'malo mwa ultrashort Humalog, NovoRapid kapena Apidra. Ngati mukufuna kusankha mitundu yoyenera ya insulin yowonjezera komanso yachangu, ndiye kuti simungathe kuchita popanda kuyesa komanso zolakwika.

Mndandanda wa insulin Humalog (lispro) - awa ndi mankhwala osokoneza bongo komanso. Kapangidwe ka mamolekyulu awo ndiosiyana, koma pochita nawo zilibe kanthu. akuti Humalog amachita mwachangu komanso mwamphamvu kuposa anzawo. Komabe, si odwala onse omwe amatsimikizira izi. Pamabwalo a odwala matenda ashuga olankhula Chirasha, mutha kupeza mawu otsutsa.

Odwala omwe ali ndi matenda amtundu wa 1 ndi mtundu wa 2 omwe amawonera angayesere kusintha insulin lispro ndi mankhwala osakhalitsa. Mwachitsanzo, pa. Pamwambapo zalembedwa mwatsatanetsatane chifukwa chake izi ndizoyenera kuchita. Komanso, insulin yochepa ndiyotsika mtengo. Chifukwa adalowa m'msika zaka zambiri m'mbuyomu.