Lisiprex - (Lisiprex)

Lysiprex ndi mankhwala opangira matenda a mtima ndi mtima dongosolo. Popeza kuopsa kwa vuto la kuchipatala, limagwiritsidwa ntchito limodzi ndi mankhwala ena kapena ngati chida chayokha. Pofuna kuti mtima ugwire ntchito pafupipafupi matenda osachiritsika, mankhwalawa amapatsidwa prophylactic.

Zotsatira za pharmacological

Mankhwalawa akuphatikizidwa ndi gulu la ACE zoletsa. Lisinopril amachedwetsa ntchito ya ACE (angiotensin-kutembenuza enzyme). Chifukwa cha izi, kuchuluka kwa angiotensin a mtundu woyamba mpaka wachiwiri, womwe umakhala ndi tanthauzo la vasoconstrictive ndikuthandizira kupanga aldosterone ndi adrenal cortex, yafupika.

Mankhwalawa amachepetsa kupanikizika m'mitsempha yaying'ono ya m'mapapo, ndikukulitsa kukana kwa voliyumu ya mtima. Imasinthasintha glomerular endothelium, ntchito zomwe zimalephera odwala ndi hyperglycemia.

The yogwira chinthu amakulitsa ochepa makoma kuposa zimakhudza bedi venous. Pogwiritsa ntchito mankhwalawa kwa nthawi yayitali, mtima ochita kusuntha wamtima umachepa. Chipangizocho chimachepetsa kuchepa kwa mtima wamanzere wamtima, kukonza mkhalidwe wa anthu omwe adakumana ndi vuto la mtima.

Pharmacokinetics

Kumwa mankhwalawa sikugwirizana ndi chakudya. Njira ya mayamwidwe imadutsa mpaka 30% ya zomwe zimagwira. Bioavailability ndi 29%. Kumangiriza kumapuloteni amwazi ndikochepa. Popanda kusintha, zinthu zikuluzikulu komanso zothandizira zimalowa m'magazi.

Kuzungulira kwakukulu kwa plasma kumawonedwa mkati mwa maola 6. Pafupifupi sanachite nawo kagayidwe kachakudya. Amayidulira osasintha kudzera mu impso. Kuchotsa theka moyo kumatenga mpaka maola 12,5.

Kodi limayikidwa kuti?

Zisonyezero zogwiritsa ntchito lysiprex:

• zofunika komanso kukonzanso mtundu wa ochepa hypotension,
• matenda ashuga nephropathy,
• kulephera kwa mtima kosatha
• pachimake myocardial infaration.

Pa vuto la mtima kwambiri, mankhwalawa amayenera kumwedwa tsiku loyamba pambuyo potiwukira kuti aletse kukomoka kwa mtima wamanzere.

Contraindication

Milandu yachipatala yochepetsa kuyang'anira kwa Lysiprex:

• Hypersensitivity pamagulu a mankhwala,
• kupezeka kwa Quincke edema mu mbiri ya mabanja,
• chibadwa chizolowezi chotere monga angioedema.

Zoyipa zokhudzana, pomwe ntchito Lysiprex imaloledwa, koma mosamala komanso kuwunika momwe wodwalayo alili,

• mitral stenosis, msempha, aimpso,

• mtima ischemia
• kukula kwa ochepa hypotension,
• kuvulala kwambiri aimpso,
• kukhalapo kwa kuchuluka kwa potaziyamu m'thupi,
• autoimmune connective minofu matenda.

Sizoletsedwa kugwiritsa ntchito mankhwalawa pochiza matenda a mtima mwa odwala omwe ali nthumwi za mtundu wakuda.

Momwe mungasamalire?

Mapiritsi amatengedwa kwathunthu osafuna kutafuna, mosasamala kanthu ndi chakudyacho. Mlingo wovomerezeka wapakati ndi 20 mg patsiku, chiwerengero chovomerezeka tsiku lililonse ndi 40 mg. Kutalika kwa mankhwalawa amawerengedwa payekhapayekha, kutengera kuwopsa kwa matendawa komanso kukula kwa zizindikiro zake. The achire zotsatira kumwa mankhwalawa kuonekera pambuyo 14-30 masiku.

Mlingo wa monotherapy wa mtima wosalephera: Mlingo woyambirira - 2,5 mg patsiku. Kwa masiku 3-5, kuwonjezera kwa 5-10 mg patsiku ndikotheka. Chovomerezeka chokwanira ndi 20 mg.

Therapy pambuyo kugunda kwa mtima mu maora 24 pambuyo pa kuukira: 5 mg, tsiku lililonse tsiku lililonse limanenedwanso chimodzimodzi. Pambuyo pa masiku awiri, muyenera kumwa 10 mg, tsiku lotsatira, mlingo umabwerezedwa pa mlingo wa 10 mg. Njira yochizira imatha kukhala kwa milungu 4 mpaka 6.

Matenda a shuga - nephropathy mpaka 10 mg patsiku, ngati pali chithunzi chachikulu, mulingo wake ungathe kuchuluka mpaka 20 mg tsiku lililonse.

Tulutsani mawonekedwe, ma CD ndi kapangidwe kake

Mapiritsiwo ndi oyera, ozungulira, osalala, okhala ndi bevel ndi notch.

Othandizira: calcium hydrogen phosphate anhydrous - 50 mg, mannitol - 20 mg, chimanga wowuma - 34,91 mg, talc - 3 mg, magnesium stearate - 1,2 mg.

Ma PC 10 - matumba otumphukira (3) - mapaketi a makatoni.
30 ma PC - zitini za polima (1) - mapaketi a makatoni.

Zizindikiro zamankhwala

Chofunikira ndi kukonzanso kwamitsempha yamagazi (mu mawonekedwe a monotherapy kapena kuphatikiza mankhwala ena a antihypertensive).

Kulephera kwamtima kosalekeza (monga gawo la mankhwala othandizira).

Pachimake myocardial infarction (mu maola 24 oyambirira okhala ndi magawo a hemodynamic osasunthika kuti azitha kutsimikizira izi ndikupewa kumanzere kwamitsempha yama mtima ndi mtima kulephera.

Diabetesic nephropathy (kuchepetsa Albinuria odwala omwe ali ndi shuga yemwe amadalira matenda a shuga) omwe ali ndi magazi abwinobwino komanso odwala omwe samadalira matenda a shuga omwe amakhala ndi matenda oopsa a shuga.

Zotsatira zoyipa

Kuchokera pamtima dongosolo: ochepa hypotension, ululu kumbuyo kwa sternum ndikotheka.

Kuchokera kumbali ya chapakati mantha dongosolo: chizungulire, kupweteka mutu, kufooka kwa minofu.

Kuchokera mmimba: kupukusa m'mimba, kusanza, kusanza.

Kuchokera pakupuma dongosolo: chifuwa chowuma.

Kuchokera ku hemopoietic dongosolo: agranulocytosis, kuchepa kwa hemoglobin ndi hematocrit (makamaka pogwiritsa ntchito nthawi yayitali), pazochitika zokhazokha - kuwonjezeka kwa ESR.

Pa gawo la madzi-electrolyte kagayidwe: hyperkalemia.

Metabolism: kuchuluka kwa creatinine, urea nayitrogeni (makamaka odwala matenda a impso, matenda a shuga, kupatsanso matenda oopsa).

Thupi lawo siligwirizana: zotupa pakhungu, angioedema.

Zina: padera - arthralgia.

Malangizo apadera

Lisinopril sayenera kugwiritsidwa ntchito mwa odwala aortic stenosis, mtima wa m'mapapo. Osagwiritsa ntchito odwala omwe ali ndi vuto lalikulu la infration: ndikuwopseza kwambiri hemodynamic kuwonongeka chifukwa chogwiritsa ntchito vasodilator, omwe ali ndi vuto laimpso.

Pamaso pa mankhwala komanso ntchito, ntchito ya impso iyenera kuyang'aniridwa.

Musanayambe chithandizo ndi lisinopril, ndikofunikira kulipiritsa kutayika kwa madzi ndi mchere.

Amagwiritsidwa ntchito mosamala kwambiri odwala omwe ali ndi vuto laimpso, ndi aimpso a stenosis, komanso mtima wambiri woopsa.

The mwayi wokhala ochepa ochepa hypotension ukuwonjezeka ndi madzimadzi kuwonongeka chifukwa diuretic mankhwala, zakudya ndi yoletsa mchere, nseru, ndi kusanza.

Odwala omwe ali ndi vuto la mtima wosakhazikika bwino kapena wochepetsedwa wamagazi, lisinopril ingayambitse ochepa ochepa hypotension.

Kugwiritsa ntchito munthawi yomweyo kwa lisinopril okhala ndi potaziyamu wothandiza kuchepetsa zakudya, zowonjezera zakudya pazakudya ndi mchere zomwe zili ndi potaziyamu sizikulimbikitsidwa.

Pogwiritsa ntchito munthawi yomweyo kugwiritsa ntchito lisinopril ndi kukonzekera kwa lifiyamu, kuyang'aniridwa kwa lifiyamu m'magazi a magazi kuyenera kuyang'aniridwa.

Kuyanjana kwa mankhwala osokoneza bongo

Pogwiritsa ntchito munthawi yomweyo ndi antihypertensive othandizira, mphamvu yowonjezera antihypertensive ndiyotheka.

Pogwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo a potaziyamu (spironolactone, triamteren, amiloride), kukonzekera kwa potaziyamu, m'malo mwa mchere wokhala ndi potaziyamu, chiopsezo cha hyperkalemia chikuwonjezeka, makamaka kwa odwala omwe ali ndi vuto laimpso.

Pogwiritsa ntchito munthawi yomweyo ACE zoletsa ndi NSAIDs, chiopsezo chokhala ndi vuto la impso chimawonjezeka, Hyperkalemia sichioneka.

Pogwiritsa ntchito munthawi yomweyo ndi "loop" diuretics, thiazide diuretics, antihypertensive effect imakhala yolimbikitsidwa. Kumachitika kwa ochepa ochepa hypotension, makamaka mutatenga koyamba muyezo wa okodzetsa, zikuwoneka chifukwa cha hypovolemia, komwe kumapangitsa kuchepa kwapang'onopang'ono kwa hypotensive zotsatira za lisinopril. Chiwopsezo chowonjezeka cha impso.

Pogwiritsidwa ntchito munthawi yomweyo ndi indomethacin, mphamvu ya antihypertensive imatsika, mwachidziwikire chifukwa cha chopinga cha kuphatikiza kwa prostaglandin mothandizidwa ndi NSAIDs (omwe amakhulupirira kuti amatenga nawo gawo pakukweza kwa hypotensive zotsatira za ACE zoletsa).

Pogwiritsa ntchito munthawi yomweyo ndi insulin, othandizira a hypoglycemic, zotumphukira za sulfonylurea, hypoglycemia imatha kuyamba chifukwa cha kulolerana kwa shuga.

Pogwiritsa ntchito munthawi yomweyo ndi clozapine, kuchuluka kwa clozapine m'madzi a m'magazi kumachulukanso.

Pogwiritsa ntchito munthawi yomweyo ndi lithiamu carbonate, kuchuluka kwa maamuamu m'magazi a seramu kumawonjezera, limodzi ndi zizindikiro za kuledzera wa lithiamu.

Nkhani yakukula kwa matenda oopsa oopsa kwa munthu wodwala matenda a shuga ogwiritsira ntchito munthawi yomweyo ndi lovastatin akufotokozedwa.

Anafotokoza kuti pali vuto lalikulu la kusintha kwa mtima womwe umagwiritsidwa ntchito nthawi imodzi ndi perorid.

Pogwiritsa ntchito munthawi yomweyo ndi ethanol, zotsatira za ethanol zimatheka.

Zizindikiro zogwiritsidwa ntchito

Lysiprex iyenera kutengedwa ngati pali zotsatirazi:

1. Matenda oopsa a arterial - ofunika komanso okonza (onse ngati mankhwala okhawo komanso osakanikirana ndi mankhwala ena)
2. Kulephera kwamtima kosalekeza (monga gawo la chithandizo chophatikiza)
3. Tsiku loyamba pambuyo pachimake myocardial infarction, komanso monga gawo la mankhwala
4. Matenda a shuga - nephropathy - kuchepetsa Albinuria

Njira yogwiritsira ntchito

Ndikulimbikitsidwa kuti mutenge Lysiprex m'mawa kamodzi patsiku. Kugwiritsa ntchito mankhwalawa sikudalira chakudya.

Odwala omwe ali ndi matenda oopsa omwe satenga mankhwalawa amapatsidwa ma milligram asanu a Lisiprex. Ngati palibe chochita, mankhwalawa amawonjezeka ndi mamiligalamu asanu masiku awiri alionse mpaka atatu, mpaka atafika pa 20 mamiligalamu patsiku.

Mlingo wokhazikika wa tsiku ndi tsiku ndi mamiligalamu 20 a mankhwalawo, ndipo pazokwanira zake ndi 40. Zotsatira zathunthu zimachitika pambuyo pa milungu iwiri kapena inayi.

Kwa anthu omwe ali ndi vuto lalikulu la mtima, mankhwalawa ayamba ndi mamiligalamu 2,5 patsiku. Pambuyo masiku atatu mpaka asanu, amaloledwa kuwonjezera mpaka mamiligalamu 5-10. Mulingo wambiri watsiku ndi tsiku mamilimita 20.

Ngati wodwala wadwala matenda osokoneza bongo oopsa, ayenera kupatsidwa mamiligalamu 5 a Lysiprex masana, ndi ma milligram ena asanu patsiku. M'tsogolomu, ndikofunikira kumwa ma milligram 10 a mankhwala pambuyo masiku awiri ndi wina 10 pambuyo pa tsiku limodzi. Njira ya mankhwala kumatenga milungu isanu ndi umodzi.

Ndi diabetesic nephropathy, tikulimbikitsidwa kumwa mamililita 10 a mankhwala patsiku. Ngati ndi kotheka, ikhoza kuwonjezeredwa mpaka 20 milligrams.

Kutulutsa mawonekedwe, zikuchokera

Mankhwala omwe ali pamwambawa amapezeka m'mitundu iyi:

Zomwe zikuchokera ku Lysiprex zimaphatikizapo zinthu izi:

• 5, 10 kapena 20 mamilimita a lisinopril mu mawonekedwe a lisinopril dihydrate
• 40, 50 kapena 100 mamiligalamu a anhydrous calcium hydrogen phosphate
• 15, 20 kapena 40 mamilimita a mannitol
• 34.91, 36.06 kapena 69.83 mamililita a wowuma chimanga
• 2,5, 3 kapena 6 mamiligalamu a talcum ufa
• 1, 1,2 kapena 2.4 mamilimita a magnesium stearate.

Kuchita ndi mankhwala ena

Mukamagwiritsa ntchito Lysiprex, ndikofunikira kuganizira za momwe zimagwirira ntchito ndi mankhwala ena, omwe afotokozeredwe pansipa:

1. Kuphatikiza kwa mankhwala ofotokozedwawo pokonzekera potaziyamu, kuthana ndi potaziyamu, kuthira mchere, kuphatikizapo potaziyamu, komanso cyclosporine, kumawonjezera mwayi wokhala ndi hyperkalemia
2. Kugwiritsa ntchito munthawi yomweyo lysiprex ndi okodzetsa, ma beta-blockers, oletsa calcium pang'onopang'ono, ma antipsychotic, antidepressants atatu ndi anti-hypertension mankhwala kumathandizira antihypertensive zotsatira
3. Kuphatikizidwa ndi kukonzekera kwa lithiamu kungapangitse kuwonjezeka kwazinthu izi m'magazi
4. Kuphatikizika kwa lysiprex ndi mankhwala a hypoglycemic kumawonjezera mphamvu zawo ndipo kungayambitse kukula kwa hypoglycemia
5. Mankhwala osagwirizana ndi antisteroidal, estrogens, and adrenergic agonists amachepetsa mphamvu ya lisiprex. Kuphatikiza apo, kuphatikiza ndi mtundu woyamba wamankhwala kungayambitse matenda aimpso.
6. Kugwiritsa ntchito nthawi yomweyo lysiprex posankha zotsekemera za ma cellotonin kungayambitse hyponatremia.
7. Kuphatikizidwa kwa mankhwala ofotokozeredwa ndi Mowa kumathandizira zotsatira za omaliza.
8. Kuphatikizika kwa lisiprex ndi procainamide, cytostatics ndi allopuripole kungayambitse leukopenia
9. Indomethacin amachepetsa mphamvu ya antihypertensive ya lisiprex
10. Mukamagwiritsa ntchito lysiprex ndi clozapine, kuchuluka kwa omwe ali m'magazi kumawonjezeka

Pali mankhwala angapo omwe sangathe kuphatikizidwa ndi lysiprex. Izi zikuphatikiza:

Zotsatira zoyipa

Kugwiritsa ntchito lysiprex kumatha kuyambitsa zotsatirazi:

1. Ululu mu sternum
2. Kupsinjika kwamphamvu
3. Tachycardia
4. Bradycardia
5. Myocardial infaration
6. Zizindikiro Zowonjezera za Kulephera Kwa Mtima
7. Kuwonongeka kwa atrioventricular conduction
8. Chizungulire
9. Mutu
10. Paresthesia
11. Kulephera
12. Asthenic syndrome
13. Zingwe
14. Kugona
15. Kusokonezeka
16. Agranulocytosis
17. Leukopenia
18. Neutropenia
19. Supombocytopenia
20. Anemia
21. Bronchospasm
22. Kupuma pang'ono
23. Anorexia
24. Pancreatitis
25. Kupweteka kwam'mimba
26. Jaundice
27. Hepatitis
28. Dyspepsia
29. Kusintha Kusintha
30. Kuyanika kwa mucosa wamlomo
31. Kuchulukitsa thukuta
32. Kusenda khungu
33. Urticaria
34. Alopecia
35. Photophobia
36. Oliguria
37. Anuria
38. Kusokonezeka kwa impso
39. Proteinuria
40. Zovuta zakugonana
41. Potaziyamu yambiri
42. Kuperewera kwa sodium
43. Arthralgia
44. Myalgia
45. Vasculitis
46. Nyamakazi
47. Thupi lawo siligwirizana

Bongo

Nthawi zambiri, zizindikiro za bongo wa Lysiprex zimachitika motsutsana ndi gawo limodzi la magalamu 50 a mankhwalawa. Amanenedwa motere:

1. Pakamwa pakamwa
2. Kugwa mwadzidzidzi
3. Kusungika kwachirendo
4. Kugona
5. Kusakwiya
6. Kudzimbidwa
7. Kuda nkhawa

Zizindikiro zotere zikawoneka, chithandizo chamankhwala chimakhala chofunikira, popeza palibe mankhwala enaake. Wodwalayo amasambitsidwa ndi m'mimba, amapatsidwa ma enterosorbents ndi mankhwala othandizira. Njira ya 0.9% sodium chloride imayendetsedwa kudzera m'mitsempha.

Hemodialysis ikhozanso kuchitidwa. Ndikofunikira kuwongolera zizindikiro zamagetsi amagetsi am'madzi, komanso kuthamanga kwa magazi.

Pa nthawi yoyembekezera

Amayi omwe akuyembekezera mwana saloledwa kutenga Lysiprex. Ngati mimba yachitika ndi chithandizo cha mankhwalawa, muyenera kusiya kumwa posachedwa.

Akatswiri atsimikizira kuti kugwiritsa ntchito mankhwalawa munthawi yachiwiri komanso yachitatu kumakhala ndi vuto pa mwana wosabadwayo, komwe kumawonetsedwa kuchepa kwa kuthamanga kwa magazi, kukula kwa kulephera kwa impso, cranial hypoplasia, hyperkalemia, ndi kufa kwa intrauterine.

Ponena za trimester yoyamba ya kubereka, palibe umboni uliwonse wa zoyipa za Lisiprex pa mwana wosabadwayo. Koma muyenera kukumbukira kuti mankhwalawa amatha kulowa mu placenta.

Migwirizano ndi magwiritsidwe akusungidwa

Sungani mankhwalawo pamalo owuma, otetezedwa ku kuwala kowonekera mwachindunji komanso kwa ana. Kutentha kosungira sikuyenera kupitirira 25 digiri Celsius.

Moyo wa alumali wa Lysiprex ndi zaka ziwiri.

Mpaka pano, Lysiprex sapezeka m'mafakitoreya a Russian Federation.

Pakadali pano, kuzipatala za ku Ukraine, Lisiprex sogulitsa.

Pazipangizo zamankhwala zamakono, pali mankhwala angapo omwe ali ofanana ndi zomwe amachita ku Lisiprex. Izi ndi monga mankhwalawa:

Mpaka pano, palibe ndemanga pa Lysiprex pa intaneti. Koma kumapeto kwa nkhaniyi, mutha kudziwa malingaliro a anthu omwe amawagwiritsa ntchito ngati mankhwala.

Ngati munayamba mwadyapo mankhwalawa, chonde gawanani ndi owerenga anu ena.

Kuchokera kumbali ya kagayidwe

Kuchulukitsa kuchuluka kwa creatinine. Mwa anthu omwe ali ndi vuto la impso ndi matenda amilandu, matenda a urea nayitrogeni amawonjezeka.

Zotupa pakhungu, kukula kwa angioedema.

Sikoyenera kupereka zida zovuta kwa anthu omwe amakhala ndi chizungulire komanso kupweteka kwam'mutu mutatenga Lisiprex.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Pali chiopsezo cha mavuto obwera chifukwa cha mwana wosabadwayo, makamaka mu 2 ndi 3 ya trimester ya gestation. Mayi yemwe akutenga mapiritsi a Lysiprex atatha kuphunzira za pakati ayenera kusiya kumwa mankhwalawo. Palibe umboni woti mwina mankhwalawo amagwira ntchito mkaka wa m'mawere. Mukamayamwitsa, kumwa mankhwalawa ndizoletsedwa chifukwa chawopsezo cha mwana.