Malangizo ogwiritsira ntchito "Lantus Solostar": kapangidwe, analogi, mtengo ndi kuwunika kwamakasitomala

Lantus ndi imodzi mwazithunzi zopanda pake za insulin ya munthu. Kupezeka m'malo mwa amino acid katsitsumzukwa ndi glycine pa 21 malo A ndi unyolo ndikuwonjezera awiri arginine amino acid mu B unyolo ku terminal amino acid. Mankhwalawa amapangidwa ndi kampani yayikulu yopanga mankhwala ku France - Sanofi-Aventis. Popita maphunziro ambiri, zidatsimikiziridwa kuti insulin Lantus sikuti imangochepetsa chiopsezo cha hypoglycemia poyerekeza ndi mankhwala a NPH, komanso imathandizira kagayidwe kazachilengedwe. Pansipa pali malangizo achidule ogwiritsa ntchito ndi kuwunika kwa odwala matenda ashuga.

Kuchita ndi mankhwala ena

Pali mankhwala omwe amakhudza kagayidwe kazakudya, pomwe akuwonjezera kapena kuchepetsa kufunika kwa insulin.

Chepetsa shuga: pakamwa antidiabetesic othandizira, sulfonamides, ACE zoletsa, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Onjezani shuga: mahomoni a chithokomiro, diuretics, sympathomimetics, kulera kwapakamwa, zotumphukira za phenothiazine, proteinase inhibitors.

Zinthu zina zimakhala ndi mphamvu ya hypoglycemic komanso hyperglycemic. Izi zikuphatikiza:

• beta blockers ndi mchere wa lithiamu,
• mowa
• clonidine (antihypertensive mankhwala).

Contraindication

1. Ndi zoletsedwa kugwiritsa ntchito mwa odwala omwe ali ndi vuto la insulin glargine kapena othandizira.
2. Hypoglycemia.
3. Chithandizo cha matenda ashuga ketoacidosis.
4. Ana osakwana zaka 2.

Zotheka zimachitika kawirikawiri, malangizowo akuti mwina atha:

• lipoatrophy kapena lipohypertrophy,
• matupi awo sagwirizana (edema ya Quincke, mantha onse, bronchospasm),
• kupweteka kwa minyewa ndi kuchedwa mu thupi la ayodini,
• dysgeusia ndi kuwonongeka kwa mawonekedwe.

Kusintha kupita ku Lantus kuchokera ku insulin ina

Ngati munthu wodwala matenda ashuga agwiritsa ntchito ma insulin apakatikati, ndiye kuti musinthana ndi Lantus, muyezo ndi mtundu wa mankhwalawo umasinthidwa. Kusintha kwa insulin kuyenera kuchitika kokha kuchipatala.

M'tsogolomu, dokotala amayang'ana shuga, njira yodwalayo, kulemera kwake ndikusintha kuchuluka kwa mayendedwe omwe amaperekedwa. Pakatha miyezi itatu, kugwiritsa ntchito bwino kwa mankhwalawa kungayang'anitsidwe ndikusanthula kwa hemoglobin ya glycated.

Malangizo pavidiyo:

Nkhani ya m'modzi wa owerenga athu, Inga Eremina:

Kulemera kwanga kunali kovutitsa, ndimalemera ngati 3 sumo wrestler ophatikizidwa, omwe ndi 92kg.

Momwe mungachotsere kulemera kwathunthu? Kodi mungathane ndi kusintha kwa mahomoni ndi kunenepa kwambiri? Koma palibe chomwe chimasokoneza kapena chinyamata kwa munthu monga kuchuluka kwake.

Koma chochita kuti muchepetse kunenepa? Opaleshoni ya laser liposuction? Ndinazindikira - osachepera 5000 dollars. Njira zama Hardware - kutikita minofu ya LPG, cavitation, kukweza kwa RF, myostimulation? Zotsika mtengo zochepa - maphunzirowa amatenga ndalama zokwana ma ruble 80,000 ndi katswiri wazakudya zothandizira. Mutha kuyesa kuthamanga, mpaka kumisala.

Ndipo kupeza nthawi yonseyi? Inde komanso okwera mtengo kwambiri. Makamaka tsopano. Chifukwa chake, ndekha, ndidasankha njira ina.

Ku Russia, onse odwala matenda a shuga omwe amadalira insulin adasamutsidwa kuchoka ku Lantus kupita ku Tujeo. Malinga ndi kafukufuku, mankhwalawa ali ndi chiopsezo chochepa cha kukhala ndi hypoglycemia, koma machitidwe ambiri anthu amadandaula kuti atasinthira ku Tujeo shuga wawo adalumphira kwambiri, motero amakakamizidwa kugula okha Lantus Solostar insulin.

Levemir ndi mankhwala abwino kwambiri, koma ali ndi chinthu china chogwira ntchito, ngakhale nthawi yayitali ndi maola 24.

Aylar sanakumane ndi insulin, malangizo akuti uyu ndi Lantus yemweyo, koma wopanga ndi wotsika mtengo.

Insulin Lantus pa nthawi yapakati

Maphunziro a zachipatala a Lantus omwe ali ndi amayi apakati sanachitike. Malinga ndi zomwe sizinalembedwera, mankhwalawa samakhudza kwambiri mayendedwe a mwana komanso iyemwini.

Kuyesera kunachitika pa zinyama, pomwepo zimatsimikiziridwa kuti insulin glargine ilibe vuto la kubereka.

Lantus Solostar woyembekezera atha kutumikiridwa pokhapokha insulin NPH isagwire ntchito. Amayi amtsogolo akuyenera kuwunika shuga wawo, chifukwa mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, komanso mu trimester yachiwiri ndi yachitatu.

Osawopa kuyamwitsa mwana; malangizo ake alibe zomwe Lantus imatha kudutsa mkaka wa m'mawere.

Tsiku lotha ntchito ya Lantus ndi zaka 3. Muyenera kusungira m'malo amdima otetezedwa ndi kuwala kwa dzuwa pa kutentha kwa madigiri 2 mpaka 8. Nthawi zambiri malo abwino kwambiri ndi firiji. Poterepa, onetsetsani kuti mwayang'ana kutentha, chifukwa kuzizira kwa insulin Lantus koletsedwa!

Kuyambira koyamba kugwiritsa ntchito, mankhwalawa amatha kusungidwa kwa mwezi umodzi m'malo opanda khungu pamtunda wa osaposa 25 digiri (osati mufiriji). Osagwiritsa ntchito insulin yomwe yatha.

Poti mugule, mtengo

Lantus Solostar amalembedwa mwaulere ndi mankhwala ndi endocrinologist. Komanso zimachitika kuti wodwala matenda ashuga ayenera kugula yekha mankhwala ku pharmacy. Mtengo wamba wa insulin ndi ma ruble 3300. Ku Ukraine, Lantus angagulidwe 1200 UAH.

Odwala matenda ashuga akuti ndi insulin yabwino kwambiri, kuti shuga yawo imasungidwa mwa malire. Nazi zomwe anthu akunena za Lantus:

Ambiri adangotsala ndemanga zabwino zokha. Anthu angapo adanena kuti Levemir kapena Tresiba ndiwofunikira.

Lantus Solostar

Lantus solostar 100ed / ml 3ml 5 ma PC. yankho la subcutaneous makonzedwe. mu sp. -gwira.

Kukonzekera kwa Sanofi (Russia): Lantus solostar

Analogs ochokera m'gulu Insulin

Actrapid nm 100 u / ml 10 ml jakisoni

Kukonzekera kwa Novo Nordisk A / C (Denmark): Actrapid nm

Humalog 100me / ml 3ml 5 ma PC. njira yothetsera mtsempha wama cartridge

Eli Lilly East S.A. (France) Kukonzekera: Humalog

Biosulin n 100me / ml 3ml 5 ma PC. kuyimitsidwa kwa subcutaneous makonzedwe. mu sp. -gwira.

Kukonzekera kwa Pharmstandard Rx (Russia): Biosulin n

Levemir flekspen 100ed / ml 3ml 5 ma PC. rr-r yokonza makatani a ma cartridge. mu sp. -gwira.

Kukonzekera kwa Novo Nordisk A / C (Denmark): Levemir flekspen

Analogs ochokera m'gulu la Matenda A shuga

5 mg maninil 120 ma PC. mapiritsi

Kukonzekera kwa Berlin Chemie (Germany): Maninil

Glformin 1000mg 60 ma PC. mapiritsi okhala ndi filimu

Kukonzekera kwa Akrikhin (Russia): Glformin

Glurenorm 30mg 60 ma PC. mapiritsi

Kukonzekera kwa Beringer Ingelheim Pharma (Germany): Glurenorm

Siofor 500mg 60 ma PC. mapiritsi okutira

Kukonzekera kwa Berlin Chemie (Germany): Siofor 500

Siofor 850mg 60 ma PC. mapiritsi okutira

Kukonzekera kwa Berlin Chemie (Germany): Siofor 850

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Njira yothetsera utsogoleri wa sc ndi yowonekera, yopanda utoto kapena wopanda utoto.

Othandizira: metacresol (m-cresol) - 2.7 mg, zinc chloride - 0,0626 mg (yofanana ndi 30 μg zinc), glycerol (85%) - 20 mg, sodium hydroxide - mpaka pH 4.0, hydrochloric acid - mpaka pH 4.0, madzi d / ndi - mpaka 1 ml.

3 ml - makatoni ochokera pagalasi owoneka bwino, opanda mtundu (mtundu I), wokwera mu zolembera za SoloStar zotayika syringe (5) - mapaketi okhala ndi makatoni okhala ndi makatoni osungira.

Zotsatira za pharmacological

ZITSANZO ZOFUSA ZA STLIMM!

Chithandizo cha Lantus ndi insulin glargine. Amapezeka ndi majini obwezeretsanso pogwiritsa ntchito mtundu wa k-12 wa bakiteriya Escherichia coli. M'malo osaloŵerera, samasungunuka pang'ono, mu acid acid sing'anga imasungunuka ndikupanga microprecipitate, yomwe imatulutsa insulin mosalekeza. Chifukwa cha izi, Lantus ali ndi mbiri yosavuta kuchitira mpaka maola 24.

Nkhani ya m'modzi wa owerenga athu Alina R.

Ndalama nthawi zonse wakhala nkhawa yanga. Chifukwa cha izi, ndinali ndi mitu yambiri. Ndinkadziwona ngati wolephera, mavuto kuntchito komanso m'moyo wanga. Komabe, ndidasankha kuti ndikufunikirabe thandizo pandekha. Nthawi zina zimawoneka kuti nkhaniyo ili mwa inu nokha, zolephera zonse zimangokhala chifukwa cha mphamvu zoipa, maso oyipa, kapena mphamvu ina yoyipa.

Ndikosavuta kukhala wachimwemwe kugwira ntchito ngati cashier kwa 26t.r. mukamayenera kulipira 11 chikwi pa nyumba yobwereka. Zomwe ndidadabwitsidwa pomwe moyo wanga wonse udasinthira mwadzidzidzi usiku umodzi kukhala wabwino. Sindingaganize konse kuti ndizotheka kuti mutha kupeza ndalama zochuluka kwambiri kotero kuti ena amangoona poyambira kungakhale ndi zotulukapo zotere. Zonse zidayamba chifukwa choti ndidalamula yanga.

Kupanga kwakukulu pa pharmacological:

• Ochepa adsorption ndi mbiri yopanda kanthu mkati maola 24.
• Kuponderezedwa kwa proteinolysis ndi lipolysis mu adipocytes.
• Gawo lolimbikira limamangirira ma insulin receptors maulendo 5-8 mwamphamvu.
• Kukuwongolera kagayidwe kachakudya kagayidwe kachakudya, kuletsa shuga kupangika kwa chiwindi.

Mu 1 ml Lantus Solostar muli:

• 3.6378 mg wa insulin glargine (malinga ndi 100 IU ya insulin ya anthu),
• 85% glycerol
• madzi a jakisoni
• hydrochloric wozungulira asidi,
• m-cresol ndi sodium hydroxide.

Lantus - njira yowonekera yothandizira jakisoni wa sc, imapezeka mu:

• makatoni a dongosolo la OptiKlik (5pcs pa paketi iliyonse),
• Syringe zolembera Lantus Solostar,
• Syringe cholembera ya OptiSet mu phukusi limodzi 5 ma PC. (magawo 2),
• Mbale 10 ml (magawo 1000 mu vala imodzi).

Zizindikiro zogwiritsidwa ntchito

1. Akuluakulu ndi ana ochokera zaka 2 zokhala ndi matenda amtundu wa 1.
2. Type 2 shuga mellitus (pankhani ya kusagwira kwa mapiritsi).

Mukunenepa kwambiri, kuphatikiza mankhwalawa ndikothandiza - Lantus Solostar ndi Metformin.

Kuchita ndi mankhwala ena

Pali mankhwala omwe amakhudza kagayidwe kazakudya, pomwe akuwonjezera kapena kuchepetsa kufunika kwa insulin.

Chepetsa shuga: pakamwa antidiabetesic othandizira, sulfonamides, ACE zoletsa, salicylates, angioprotectors, monoamine oxidase inhibitors, antiarrhythmic dysopyramides, narcotic analgesics.

Onjezani shuga: mahomoni a chithokomiro, diuretics, sympathomimetics, kulera kwapakamwa, zotumphukira za phenothiazine, proteinase inhibitors.

Zinthu zina zimakhala ndi mphamvu ya hypoglycemic komanso hyperglycemic. Izi zikuphatikiza:

• beta blockers ndi mchere wa lithiamu,
• mowa
• clonidine (antihypertensive mankhwala).

Contraindication

1. Ndi zoletsedwa kugwiritsa ntchito mwa odwala omwe ali ndi vuto la insulin glargine kapena othandizira.
2. Hypoglycemia.
3. Chithandizo cha matenda ashuga ketoacidosis.
4. Ana osakwana zaka 2.

Zotheka zimachitika kawirikawiri, malangizowo akuti mwina atha:

• lipoatrophy kapena lipohypertrophy,
• matupi awo sagwirizana (edema ya Quincke, mantha onse, bronchospasm),
• kupweteka kwa minyewa ndi kuchedwa mu thupi la ayodini,
• dysgeusia ndi kuwonongeka kwa mawonekedwe.

Kusintha kupita ku Lantus kuchokera ku insulin ina

Ngati munthu wodwala matenda ashuga agwiritsa ntchito ma insulin apakatikati, ndiye kuti musinthana ndi Lantus, muyezo ndi mtundu wa mankhwalawo umasinthidwa. Kusintha kwa insulin kuyenera kuchitika kokha kuchipatala.

M'tsogolomu, dokotala amayang'ana shuga, njira yodwalayo, kulemera kwake ndikusintha kuchuluka kwa mayendedwe omwe amaperekedwa. Pakatha miyezi itatu, kugwiritsa ntchito bwino kwa mankhwalawa kungayang'anitsidwe ndikusanthula kwa hemoglobin ya glycated.

Malangizo pavidiyo:

Nkhani ya m'modzi wa owerenga athu, Inga Eremina:

Kulemera kwanga kunali kovutitsa, ndimalemera ngati 3 sumo wrestler ophatikizidwa, omwe ndi 92kg.

Momwe mungachotsere kulemera kwathunthu? Kodi mungathane ndi kusintha kwa mahomoni ndi kunenepa kwambiri? Koma palibe chomwe chimasokoneza kapena chinyamata kwa munthu monga kuchuluka kwake.

Koma chochita kuti muchepetse kunenepa? Opaleshoni ya laser liposuction? Ndinazindikira - osachepera 5000 dollars. Njira zama Hardware - kutikita minofu ya LPG, cavitation, kukweza kwa RF, myostimulation? Zotsika mtengo zochepa - maphunzirowa amatenga ndalama zokwana ma ruble 80,000 ndi katswiri wazakudya zothandizira. Mutha kuyesa kuthamanga, mpaka kumisala.

Ndipo kupeza nthawi yonseyi? Inde komanso okwera mtengo kwambiri. Makamaka tsopano. Chifukwa chake, ndekha, ndidasankha njira ina.

Ku Russia, onse odwala matenda a shuga omwe amadalira insulin adasamutsidwa kuchoka ku Lantus kupita ku Tujeo. Malinga ndi kafukufuku, mankhwalawa ali ndi chiopsezo chochepa cha kukhala ndi hypoglycemia, koma machitidwe ambiri anthu amadandaula kuti atasinthira ku Tujeo shuga wawo adalumphira kwambiri, motero amakakamizidwa kugula okha Lantus Solostar insulin.

Levemir ndi mankhwala abwino kwambiri, koma ali ndi chinthu china chogwira ntchito, ngakhale nthawi yayitali ndi maola 24.

Aylar sanakumane ndi insulin, malangizo akuti uyu ndi Lantus yemweyo, koma wopanga ndi wotsika mtengo.

Insulin Lantus pa nthawi yapakati

Maphunziro a zachipatala a Lantus omwe ali ndi amayi apakati sanachitike. Malinga ndi zomwe sizinalembedwera, mankhwalawa samakhudza kwambiri mayendedwe a mwana komanso iyemwini.

Kuyesera kunachitika pa zinyama, pomwepo zimatsimikiziridwa kuti insulin glargine ilibe vuto la kubereka.

Lantus Solostar woyembekezera atha kutumikiridwa pokhapokha insulin NPH isagwire ntchito. Amayi amtsogolo akuyenera kuwunika shuga wawo, chifukwa mu trimester yoyamba, kufunika kwa insulin kumatha kuchepa, komanso mu trimester yachiwiri ndi yachitatu.

Osawopa kuyamwitsa mwana; malangizo ake alibe zomwe Lantus imatha kudutsa mkaka wa m'mawere.

Alumali moyo wa Lantus ndi zaka 3. Muyenera kusungira m'malo amdima otetezedwa ndi kuwala kwa dzuwa pa kutentha kwa madigiri 2 mpaka 8. Nthawi zambiri malo abwino kwambiri ndi firiji. Poterepa, onetsetsani kuti mwayang'ana kutentha, chifukwa kuzizira kwa insulin Lantus koletsedwa!

Kuyambira koyamba kugwiritsa ntchito, mankhwalawa amatha kusungidwa kwa mwezi umodzi m'malo opanda khungu pamtunda wa osaposa 25 digiri (osati mufiriji). Osagwiritsa ntchito insulin yomwe yatha.

Poti mugule, mtengo

Lantus Solostar amalembedwa mwaulere ndi mankhwala ndi endocrinologist. Komanso zimachitika kuti wodwala matenda ashuga ayenera kugula yekha mankhwala ku pharmacy. Mtengo wamba wa insulin ndi ma ruble 3300. Ku Ukraine, Lantus angagulidwe 1200 UAH.

Odwala matenda ashuga akuti ndi insulin yabwino kwambiri, kuti shuga yawo imasungidwa mwa malire. Nazi zomwe anthu akunena za Lantus:

Ambiri adangotsala ndemanga zabwino zokha. Anthu angapo adanena kuti Levemir kapena Tresiba ndiwofunikira.

Lantus Solostar

Lantus solostar 100ed / ml 3ml 5 ma PC. yankho la subcutaneous makonzedwe. mu sp. -gwira.

Kukonzekera kwa Sanofi (Russia): Lantus solostar

Analogs ochokera m'gulu Insulin

Actrapid nm 100 u / ml 10 ml jakisoni

Kukonzekera kwa Novo Nordisk A / C (Denmark): Actrapid nm

Humalog 100me / ml 3ml 5 ma PC. njira yothetsera mtsempha wama cartridge

Eli Lilly East S.A. (France) Kukonzekera: Humalog

Biosulin n 100me / ml 3ml 5 ma PC. kuyimitsidwa kwa subcutaneous makonzedwe. mu sp. -gwira.

Kukonzekera kwa Pharmstandard Rx (Russia): Biosulin n

Levemir flekspen 100ed / ml 3ml 5 ma PC. rr-r yokonza makatani a ma cartridge. mu sp. -gwira.

Kukonzekera kwa Novo Nordisk A / C (Denmark): Levemir flekspen

Analogs ochokera m'gulu la Matenda A shuga

5 mg maninil 120 ma PC. mapiritsi

Kukonzekera kwa Berlin Chemie (Germany): Maninil

Glformin 1000mg 60 ma PC. mapiritsi okhala ndi filimu

Kukonzekera kwa Akrikhin (Russia): Glformin

Glurenorm 30mg 60 ma PC. mapiritsi

Kukonzekera kwa Beringer Ingelheim Pharma (Germany): Glurenorm

Siofor 500mg 60 ma PC. mapiritsi okutira

Kukonzekera kwa Berlin Chemie (Germany): Siofor 500

Siofor 850mg 60 ma PC. mapiritsi okutira

Kukonzekera kwa Berlin Chemie (Germany): Siofor 850

LANTUS SoloStar

Zachipatala ndi gulu la mankhwala

Zogwira ntchito

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Njira yothetsera utsogoleri wa sc ndi yowonekera, yopanda utoto kapena wopanda utoto.

Othandizira: metacresol (m-cresol) - 2.7 mg, zinc chloride - 0,0626 mg (yofanana ndi 30 μg zinc), glycerol (85%) - 20 mg, sodium hydroxide - mpaka pH 4.0, hydrochloric acid - mpaka pH 4.0, madzi d / ndi - mpaka 1 ml.

3 ml - makatoni ochokera pagalasi owoneka bwino, opanda mtundu (mtundu I), wokwera mu zolembera za SoloStar zotayika syringe (5) - mapaketi okhala ndi makatoni okhala ndi makatoni osungira.

Zotsatira za pharmacological

Insulin glargine ndi chithunzi cha insulin ya anthu yomwe imapangidwanso ndi mabakiteriya a DNA a mtundu wa Escherichia coli (tizilombo ta K12) ndipo amadziwika ndi kusungunuka pang'ono m'malo osalowerera ndale.

Monga gawo la mankhwala Lantus SoloStar, insulin glargine imasungunuka kwathunthu, yomwe imatsimikiziridwa ndi momwe asidi amachitikira potsatira jakisoni (pH 4). Pambuyo poyambitsa mafuta ochepetsa mphamvu, acidic yankho limaphatikizidwa, zomwe zimayambitsa kupangidwa kwa microprecipitate, komwe ma insulin glargine amatulutsidwa nthawi zonse, ndikupereka chithunzi chosalala (chopanda).

Insulin glargine imapukusidwa kwa metabolites awiri ogwira ntchito, M1 ndi M2.

Kuyankhulana ndi insulin receptors: kinetics ya kumangirira kumatulidwe ena a insulin mu insulin glargine ndipo metabolites yake M1 ndi M2 ndi ofanana kwambiri ndi insulin yaumunthu, chifukwa chake insulin glargine imatha kuchita zofanana ndi insulin.

Chofunikira kwambiri cha insulin ndi mapangidwe ake, kuphatikiza ndi insulin glargine, ndiko kukhazikitsidwa kwa glucose metabolism. Insulin ndi kufananiza kwake kumachepetsa kuchuluka kwa glucose m'magazi, kumapangitsa kuti mayamwidwe azikhala ndi zotumphukira (makamaka mafupa am'mimba ndi adipose minofu) ndikuletsa kupangika kwa shuga mu chiwindi. Insulin imalepheretsa lipolysis mu adipocytes komanso inhibits proteinolysis, pamene ikukula kaphatikizidwe ka mapuloteni.

Kuchita kwa nthawi yayitali kwa insulin glargine kumakhudzana mwachangu ndi kufupika kwa mayamwidwe ake, komwe kumalola kuti mankhwalawa agwiritsidwe ntchito 1 nthawi / tsiku. Pambuyo pa kayendetsedwe ka sc, kuyambira kwa zochita zake kumachitika, pafupifupi, pambuyo pa ola 1. Nthawi yayitali yochita ndi maola 24, okwera ndi maola 29. Kutalika kwa insulin ndi mawonekedwe ake, monga insulin glargine, amatha kusiyanasiyana m'magulu osiyanasiyana kapena m'modzi wodwala yemweyo.

Kugwiritsa ntchito kwa mankhwala Lantus SoloStar mwa ana opitilira zaka 2 ndi matenda a shuga a 1 akuwonetsedwa. Mu ana omwe ali ndi zaka 2-6 zaka, ziwonetserozo za hypoglycemia zomwe zimagwiritsa ntchito insulin glargine zimachepetsedwa kawiri masana ndi usiku kuyerekeza ndi kugwiritsa ntchito insulin-isofan (motsatana, pafupifupi magawo 25,5 kutsutsana ndi zigawo 33 mu wodwala m'modzi chaka chimodzi).

Pazaka zisanu zotsatila za odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga, palibe kusiyana kwakukulu pakukula kwa matenda ashuga omwe amapezeka ndi insulin glargine poyerekeza ndi insulin-isophan.

Chiyanjano ndi ma receptors a insulin-like grow factor 1 (IGF-1): kuyanjana kwa insulin glargine ya IGF-1 receptor kumakhala pafupifupi ka 5-8 kuposa momwe insulin yamunthu (koma pafupifupi 70-80 nthawi yotsika kuposa ya IGF-1), nthawi yomweyo, poyerekeza ndi insulin yaumunthu, kagayidwe ka insulin glargine M1 ndi M2 kuyanjana kwa IGF-1 receptor ndizochepa pang'ono.

Chiwonetsero chonse cha insulin (insulin glargine ndi metabolites) chotsimikizika mu odwala 1 a mtundu wa shuga, chinali chotsika kwambiri kuposa momwe zimakhalira pakufunika kwa theka la kumangiriza kwa IGF-1 receptors ndikutsatiridwa kwa njira ya mitogenic proliferative yomwe idayambika kudzera pa IGF-1 receptors. Kuzungulira kwa thupi kwa endo native IGF-1 kumatha kuyambitsa njira ya matogenic proliferative, komabe, mankhwala a insulin omwe amatsimikiziridwa panthawi ya insulin, kuphatikiza chithandizo ndi Lantus SoloStar, ndi otsika kwambiri kuposa zovuta za pharmacological zomwe zimafunikira kuyambitsa njira ya mitogenic proliferative.

Kafukufuku wa ORIGIN (Outcome Reduction with Initial Glargine INtervention) anali kafukufuku wapadziko lonse lapansi, wophatikiza zambiri, wosasintha mwachidule omwe adachitika mwa odwala 12,537 omwe ali pachiwopsezo chachikulu chotenga matenda a mtima komanso kusala bwino kwa glucose (IHF), kuvutikirana kwa glucose (NTG) kapena poyambira mtundu 2 shuga. Ophunzira nawo adasankhidwa m'magulu awiri (1: 1): gulu la odwala lomwe limalandira insulin glargine (n = 6264), yomwe idasungidwa isanafike pagulu lopanda magazi glucose (GKN) ≤5.3 mmol, ndi gulu la odwala omwe amalandila chithandizo chamankhwala (n = 6273 )

Mapeto oyamba a phunziroli inali nthawi isanayambike imfa yamtima, kukhazikitsidwa koyamba kwa infarction yopanda magazi kapena kupha, ndipo chotsatira chachiwiri chinali nthawi isanayambike zovuta zilizonse pamwambapa kapena isanachitike njira yosinthira mafupa (coronary, carotid oripheral artery) , kapena asanagonekere kuchipatala chifukwa cha chotupa cha mtima.

Omaliza ochepa anali anthu omwalira pazifukwa zilizonse komanso chifukwa cha kuphatikizidwa.

Kafukufuku wa ORIGIN adawonetsa kuti chithandizo cha insulin glargine poyerekeza ndi chithandizo chokwanira cha hypoglycemic sichinasinthe chiwopsezo cha zovuta zamtima kapena kufa kwa mtima, panalibe zosiyana pamiyeso ya chinthu chilichonse chomwe chimapanga mfundo zomaliza, kufa kwa zonse zomwe zimayambitsa, umboni wophatikizidwa wazotsatira zamatsenga .

Kumayambiriro kwa phunziroli, mfundo za Hb A1c zapakati zinali 6.4%. Makhalidwe a Median Hb A1c panthawi yamankhwala anali mu 5.9-6.4% mu gulu la insulin glargine ndi 6.2-6.6% pagulu lachipatala nthawi zonse.

Mu gulu la odwala omwe amalandira insulin glargine, kuchuluka kwambiri kwa hypoglycemia kunali kwa zigawo za 1,05 pamankhwala opatsa zaka 100, komanso pagulu la odwala omwe adalandira chithandizo cha hypoglycemic 0,3 episode pa 100 ya zaka zothandizira odwala. Chiwopsezo cha hypoglycemia yofatsa chinali magawo 7.71 pazaka zana zothandizira odwala omwe ali ndi gulu la odwala omwe amalandira insulin glargine, komanso zochitika za 2.44 pazaka 100 zothandizira odwala omwe ali m'gulu la odwala omwe amalandila hypoglycemia. Mu kafukufuku wazaka 6, 42% ya odwala omwe ali mgululi la insulin glargine sanawonetse vuto lililonse la hypoglycemia.

Mkhalapakati wakusintha kwa kulemera kwa thupi poyerekeza ndi zotsatira paulendo womaliza wa mankhwalawa anali 2.2 kg kwambiri m'gululi la insulin glargine kuposa gulu lonse la chithandizo.

Mlingo

Njira yothetsera jakisoni 100 IU / ml

1 ml yankho lili:

zinthu zogwira ntchito: insulin glargine NOE 901 - 3.6378 mg (100 PIECES).

zotuluka: metacresol, zinc chloride, glycerin (85%), sodium hydroxide, anaikira hydrochloric acid, madzi a jakisoni.

Transparent wopanda khungu kapena pafupifupi wopanda mafuta.

Mankhwala

Poyerekeza ndi NPH-insulin, kuchuluka kwa ma seramu insulin m'maphunziro athanzi komanso odwala omwe ali ndi matenda ashuga pambuyo poyambira kukakamira kwa insulin glargine adawonetsa kuchepa komanso kuyamwa kwakanthawi, komanso kusapezeka kwa nsonga. Chifukwa chake, zoimbazo zinali molingana ndi mawonekedwe aposachedwa a pharmacodynamic ntchito ya insulin glargine. Chithunzi 1 chikuwonetsa ntchito za insulin glargine ndi NPH-insulin motsutsana ndi nthawi. Ndi kukhazikitsidwa kamodzi patsiku, kuyanjana kwa insulin glargine m'magazi kumatheka patatha masiku 2-4 pambuyo pa mlingo woyamba. Ndi mtsempha wamagazi, theka la moyo wa insulin glargine ndi insulin ya anthu anali ofanana.

Pambuyo subcutaneous jakisoni wa Lantus mwa odwala matenda a shuga, insulin glargine imapangidwa mwachangu kumapeto kwa polypeptide beta unyolo kuti apange ma metabolites awiri a M1 (21A-Gly-insulin) ndi M2 (21A-Gly-des-30B-Thr insulin). Mu plasma, gawo lalikulu lozungulira ndi metabolite M1. Kutupa kwa metabolite M1 kumawonjezera malinga ndi mlingo wa Lantus.

Zotsatira za Pharmacokinetic ndi pharmacodynamic zikuwonetsa kuti zotsatira za jekeseni wa subcutaneous wa Lantus zimachitika makamaka podzipatula kwa metabolite M1. Insulin glargine ndi metabolite M2 sizinapezeke mwa odwala ambiri, atapezeka, kuphatikiza kwawo kunali kosadalira mlingo womwe Lantus anali nayo.

M'mayesero azachipatala, kusanthula kwa maubwana omwe amapangidwa ndi zaka komanso jenda sizinawonetse kusiyana kulikonse pakuwoneka bwino komanso chitetezo pakati pa odwala omwe amathandizidwa ndi insulin glargine ndi anthu onse omwe adaphunzira.

Pharmacokinetics mwa ana a zaka 2 mpaka 6 zokhala ndi matenda a shuga 1 adayesedwa pa kafukufuku wina wamankhwala (onani "Pharmacodynamics"). Mankhwala ochepera plumma a insulin glargine ndi metabolites yake yayikulu M1 ndi M2 adayezedwa ana omwe amapezeka ndi insulin glargine, ndipo zidapezeka kuti zitsanzo za plasma za ndende zinali zofanana ndi zitsanzo za akuluakulu, umboni wotsimikizira kuchuluka kwa insulin glargine kapena ma metabolites ndi makonzedwe autali kulibe.

Insulin glargine ndi analogue ya insulin ya anthu, yopangidwira kuti isungunuke pakubwera pH. Imasungunuka kwathunthu pa acidic pH ya Lantus® In injion (pH 4). Pambuyo pothandizidwa ndi subcutaneous, yankho la acidic siligwirizana, zomwe zimapangitsa kupangika kwa microprecipitate, komwe insulin glargine imatulutsidwa mosalekeza pang'ono, kupatsanso mbiri, yopanda tsankho, yolosera za nthawi yayitali / nthawi yayitali.

Kumangiriza kwa ma insulin receptors: mu vitro maphunziro akuwonetsa kuti kuyanjana kwa insulin glargine ndi metabolites M1 ndi M2 kwa insulin receptors yaumunthu ndizofanana ndi insulin yamunthu.

IGF-1 receptor yomangiriza: kuyanjana kwa insulin glargine kwa IGF-1 receptor wamunthu kuli pafupifupi nthawi 5-8 kuposa zomwe insulin ya munthu (koma pafupifupi 70-80 nthawi yotsika kuposa IGF-1), pomwe M1 metabolites ndi M2 yomangiriza ku IGF-1 receptor yokhala ndi mgwirizano wotsika pang'ono poyerekeza ndi insulin ya anthu.

Chiwonetsero chonse cha insulin (insulin glargine ndi metabolites) chodalirika cha odwala matenda ashuga 1 chinali chotsika kuposa chomwe chimafunikira theka la kuyankha kokwanira kuchokera pakugwidwa kwa IGF-1 receptor komanso kuyambitsa njira ya progifant yotsatira ya IGF-1 . Kuzungulira kwa thupi kwa endo native IGF-1 kumatha kuyambitsa njira ya mitogenic proliferative, komabe, zozama zochizira zomwe zimatsimikiziridwa panthawi ya insulin mankhwala, kuphatikizapo Lantus chithandizo, ndizotsika kwambiri poyerekeza ndi ma pharmacological omwe amafunikira kuyambitsa njira ya IGF-1.

Chochita chachikulu cha insulin, kuphatikiza insulin glargine, ndikuwongolera kagayidwe ka glucose. Insulin ndi ma analogi ake amachepetsa kuchuluka kwa shuga m'magazi a chiwonetsero cham'mimba, makamaka minofu yamatumbo ndi minyewa ya adipose, komanso kuponderera kupangika kwa glucose m'chiwindi. Insulin imachepetsa lipolysis mu adipocytes, linalake ndipo tikulephera kuphatikiza mapuloteni. Kafukufuku wa zamankhwala ndi zamankhwala awonetsa kuti ma insulin glargine ophatikizidwa ndi insulin komanso mankhwalawa anali ofanana pakaperekedwa pa mlingo womwewo. Monga ndi ma insulin onse, zolimbitsa thupi ndi zinthu zina zimatha kusokoneza nthawi ya insulin glargine.

Kutulutsa Fomu

Insulin imapezeka m'matumba a syringe. Ili ndi njira yabwino kwa odwala matenda ashuga, popeza kuti majakisoni amatha kuchitika osati kunyumba, komanso kunja kwa nyumba. Mothandizidwa ndi cholembera, ndizosavuta kupirira mulingo wofanana, chifukwa nkhani za bongo ndizosowa kwambiri. Phukusili lili ndi ma cartridge 5 a 3 ml. Mankhwalawa amamuikidwa pabokosi lamakatoni, palinso malangizo ogwiritsira ntchito mwatsatanetsatane momwe angagwiritsire ntchito izi. Wopanga mankhwalawa ndi Frankfurt am Main Germany, wopanga mankhwalawa ku Russia ndi ZAO Sanofi-Aventis Vostok, Oryol Oblast.

Pharmacodynamics ndi pharmacokinetics

Mankhwala amapangidwa mwanjira yoti amatha kusungunuka pang'ono m'malo osaloledwa acid. M'madzi a jakisoni amasungunuka bwino komanso. Pambuyo pakubaya kwapakati, acidic sing'anga imakhala yosalowerera, ndipo mankhwalawo amakhazikika ngati ma microcrystals, omwe pang'onopang'ono amalowa m'magazi. Izi zikufotokozera zomwe zidatenga nthawi yayitali. Kupukutira kwa insulini kumathandizira kukoka kwa glucose ndi minofu, makamaka mafupa amkono ndi mafuta, komanso kumachepetsa kupanga kwa chiwindi. Chifukwa chake, kutsika kwa shuga m'magazi kumachitika. Ngati tingayerekeze machitidwe a isophane ndi kukweza, wachiwiri umachita modekha, popanda nsonga. Kuchepetsa pang'onopang'ono kwa mankhwalawa kumapangitsa kuti muzitha kugwiritsa ntchito kamodzi patsiku.

Malinga ndi kuchuluka kwa kumanga kwa insulin receptors, harling ndi insulin ya anthu ali pafupi kwambiri, chifukwa chake, jakisoni wa mankhwalawa amalekeredwa bwino ndi odwala ndikupereka zotsatira zomwe akufuna. A khola ndende ya mankhwala anati pambuyo masiku 2-4 kuchokera jekeseni woyamba ndi tsiku makonzedwe. Odwala kumva chiyambi cha achire zotsatira 60 Mphindi pambuyo jekeseni, achire zotsatira kumatenga maola 24-29. Atalowa m'thupi, Lantus, monga ma insulin onse, amayamba kuwonongeka ndipo amamuchotsa mkodzo ndi ndulu.

Zofunika! Gwiritsani ntchito cholembera mu syringe monga ananenera wopanga. Ndikofunikira kupaka insulin mosabisa m'mimba, kumtunda mwendo (ntchafu), phewa.

Zizindikiro ndi contraindication

Insulin imakhudzidwa ndikuwonongeka kwa shuga, ndipo kuchepa kwake kumapangitsa kuchuluka kwa shuga m'magazi, kumakupangitsani kuti musamve bwino. Solostar imagwiritsidwa ntchito pochiza matenda omwe amadalira insulin momwe muli kuperewera kwa mahomoni. Kuchepetsa kotereku kumayamba chifukwa cha kapamba wosakwanira chifukwa cha kubereka kapena kuyambitsa. Solotar imatha kuyenderana ndi mankhwala ena okhala ndi insulin. Pankhaniyi, ndikofunikira kuwerengera mulingo wosankha, musankhe poganizira kusiyana kwa nthawi yochitapo kanthu. Kuphatikiza mankhwala kumagwiritsidwa ntchito pochiza odwala matenda ashuga amtundu wa 2.

Contraindication pakugwiritsa ntchito Garling ndi:

• matupi awo sagwirizana ndi mankhwala
• kulephera kwambiri kwa aimpso,
• Zaka za mwana zosakwana zaka ziwiri.

Wachibale wapakati ndi pakati. Amayi oyembekezera ayenera kubayira insulin pansi pa kayendetsedwe kosalekeza ka shuga. Panthawi yonse yomwe mukukhala ndi pakati, masinthidwe a mlingo umodzi wa 2-3 amafunikira, motero, mankhwala a insulin amayenera kuyang'aniridwa ndi dokotala.

Zotsatira zoyipa

Kutengera ndi mlingo woyenera, zosafunikira zamthupi sizimachitika kawirikawiri. Koma kugwiritsa ntchito insulin nthawi yayitali kumatha kuyambitsa "mavuto".Nthawi zambiri, izi ndi kuchepa kwakulu msanga, komwe kumadziwonetsera:

• kufooka
• kudziwa zolakwika
• kuphwanya kwamkati dongosolo lamanjenje,
• kukomoka
• kugwedezeka kwamiyendo,
• hyphydrosis,
• kugunda kwamtima kolimba.

Kutsika kwina kwa glucose pansi pamlingo, akhoza kukhala ndi vuto la hypoglycemic, lomwe ndi vuto lalikulu lofunika kuchipatala. Kuphatikiza apo, odwala matenda ashuga amatha kukhala ndi malo omwe amapezeka jekeseni pafupipafupi, motero malo a jakisoni ayenera kusinthidwa. Ngati ukhondo sutsatiridwa, tsamba la jekeseni limatha kutenga kachilomboka, ndikupangitsa kukula, kuyabwa ndi kutulutsa. Odwala omwe ali ndi vuto lililonse kapena omwe ali ndi mbiri ya kugunda kwa angioedema amayesedwa kuti apatsidwe insulin. Pachifukwa ichi, jekeseni wa intradermal amapangidwa ndipo momwe thupi limayang'anira limayang'aniridwa. Ngati palibe mawonekedwe owonetsa, pitilizani insulin.

Mlingo ndi bongo

Lantus akuwonetsedwa pochiza matenda a shuga mwa akulu, achinyamata ndi ana azaka ziwiri. Ngati mankhwala a insulin amafunikira mwana wochepera zaka ziwiri, ndiye kuti mlingo umatsimikiziridwa payekhapayekha ndipo amawerengedwa kutengera kulemera kwa thupi la mwana. Wopanga mankhwalawa m'mawu akuwonetseratu momwe angapangire mankhwalawo komanso malo ake. Insulin imalowetsedwa mwa achikulire ndi ana mosamveka kamodzi patsiku, mosasamala nthawi ya tsiku, koma nthawi yomweyo. Mlingo wa mankhwalawa uyenera kuwerengera aliyense payekha.

Ndi mtundu wachiwiri wa matenda a shuga a mellitus, Solostar amachita ngati mankhwala amodzi, komanso mbali ya gulu la mankhwala. Muyenera kusintha mlingo wa mankhwalawa mukasintha mtundu wina wa insulin kupita ku imzake, ndikuchulukitsa thupi, kusintha ma jakisoni. Zinthu izi zimakhudza mphamvu ya mankhwalawa, chifukwa chake, amafunika kuwerengera kwatsopano. Asanagwiritse ntchito cholembera, dokotalayo amafotokozera wodwalayo momwe angabayire, kupaka singano, ndikusankha malo oyenera jakisoni. Kudzinyamula sikutanthauza maluso apadera, chifukwa syringe ili ndi singano yakuthwa ndipo jekeseni amapangidwa popanda kuyesetsa. Pali chenjezo limodzi - wodwala matenda ashuga ayenera kuphunzira payekha kuti adziwe kuchuluka kwa mankhwala oyenera kukhazikitsa.

Zofunika! Kupatula matenda pa jakisoni jekeseni, gwiritsani ntchito singano kamodzi. Pambuyo pa jekeseni woyamba, cholembera chimasungidwa pamalo amdima kutentha kwa firiji ndipo sichinapose mwezi umodzi.

Ngati wodwala ndi wokalamba kapena akuvutika ndi kuchepa kwa kuthekera kwa impso, komanso pakusintha kwa insulini yochepa kapena yosavuta kupita ku Solestar, ndiye kuti pali gawo lochepa la garglin. Dokotala yekha ndi amene angawerengere izi. Nthawi zambiri, "Lantus" amatchulidwa kuchuluka kwa 40-60% yaomwe adamwa kale. Mankhwala ochepa amathandizidwa kwa odwala omwe amamwa mapiritsi okhala ndi hypoglycemic.

Mankhwala osokoneza bongo amachitika chifukwa cha:

• zolakwika makonzedwe a kuchuluka kuchuluka,
• kuwerengedwa kwa cholakwika
• kusintha kwa jakisoni,
• kugwiritsa ntchito mtundu wina wa insulin.

Potere, wodwalayo amakula ndi hypoglycemia ndi chithunzi chogwirizana. Mankhwalawa ndi achangu, amwadzidzidzi.

Kuchita

Ndi munthawi yomweyo ya Lantus ndi mankhwala ochokera kumagulu ena a mankhwala, kusintha kwa nthawi ya insulin kumawonedwa. Mankhwala ena amatha kukulitsa insulin, pomwe ena amachepetsa kuchiritsa. Kuwonjezeka kwa zotsatira za hypoglycemic kumawonedwa ndi kuyanjana kwaimbirana ndi:

• ACE zoletsa, MAO,
• kukonzekera kwa salicylic acid
• sulfnilamide othandizira
• m`kamwa hypoglycemic mankhwala.

Kuchepetsa mphamvu ya insulin chifukwa:

• mowa
• kumwa mankhwala okhala ndi mahomoni a chithokomiro,
• okodzetsa
• mankhwala a steroid
• mankhwala a psychotropic.

Mukamapereka mankhwala a insulin, muyenera kudziwa mankhwala ena omwe wodwala akutenga kuti awerengere moyenera.

Ma substitutes kapena ma synonyms a Lantus Solostar ali ndi vuto lofananalo, koma amasiyana mumagulu azinthu zothandizira.

Gome limapereka mndandanda wofananira wa mankhwalawa.

M'malo atsopano a Lantus ndi Tujeo Solostar. Mankhwala amamasulidwa mu cholembera. Pa choyambirira pali zolembedwa 300ED pazithunzi zagolide. Chithunzi:

Ndi iti mwa fanizo yoyenera kwa wodwalayo, adokotala amawaganizira, poganizira zamankhwala zomwe zakhala zikuchitika komanso momwe wodwalayo alili.

Odwala, komanso madokotala, amasiya ndemanga zawo pa intaneti za mankhwalawa.

Angelina, wazaka 37, endocrinologist. Lantus ndi Tugiero ali ndi zotengera zomwezo, koma pokonzekera zimakhala zambiri. Tujeo ikufunika kwambiri pakati pa odwala matenda ashuga, chifukwa mlingo wocheperako umafunikira kuti shuga asakhale bwino.

Anna, wazaka 32. Ntchito Lantus, kenako nkusinthira ku Tujeo. Ndinkamukonda kwambiri, palibe "zotsatira zoyipa", shuga ndi yabwinobwino.

Vladislav, wazaka 46. Ndakhala ndikudwala matenda ashuga kwa zaka 10. Choyamba, adalowetsa Basis Insulin, kenako Lantus. Tsopano asinthira ku Tujeo. Ndikumva bwino, palibe zoyipa zomwe zimachitika, koma sindingaiwale zakudyazo.

Mtengo wa "Lantus" m'mafakisi ku Russia umasiyana kuchokera ku 2900 mpaka 3200 rubles pa phukusi lililonse.