Glyclazide: malangizo ogwiritsira ntchito, mtengo, mapiritsi ndi analogies a Diabeteson ndi Metformin

Gliclazide * + Metformin * (Gliclazide * + Metformin *) - Wothandizira pakamwa hypoglycemic, wotengedwa wa m'badwo wachiwiri. Imayendetsa katulutsidwe ka insulin ndi β-cell ya kapamba. Kuchulukitsa chidwi cha zotumphukira zimakhala kuti insulin. Zikuwoneka, zimapangitsa ntchito ya ma intracellular enzymes (makamaka, minofu glycogen synthetase). Amachepetsa nthawi kuchokera pakudya mpaka kuyamba kwa insulin. Kubwezeretsanso pachimake cha insulin katulutsidwe, kumachepetsa chiwerengero cha hyperglycemia pambuyo pake.

Glyclazide imachepetsa kuphatikiza kwa maselo ndi kuphatikiza, imachepetsa kukula kwa parietal thrombus, ndikuwonjezera ntchito ya mtima. Matendawa mtima kukhathamira. Ili ndi anti-atherogenic katundu: imatsitsa kuchuluka kwa cholesterol yathunthu (Ch) ndi LDL-C m'magazi, imachulukitsa kuchuluka kwa HDL-C, komanso kumachepetsa kuchuluka kwa zopitilira muyeso. Zimalepheretsa kukula kwa microthrombosis ndi atherosulinosis. Zimasintha kusintha kwakachulukidwe. Imachepetsa mphamvu ya mtima ku adrenaline.

Ndi diabetesic nephropathy yogwiritsa ntchito gliclazide nthawi yayitali, kuchepa kwakukulu kwa proteinuria kumadziwika.

Mndandanda wazofananira

Zolemba zosangalatsa

Momwe mungasankhire analog yoyenera
Mu pharmacology, mankhwala nthawi zambiri amagawidwa m'magulumagulu ndi ma analogi. Kapangidwe kazofananira kameneka kamaphatikizira amodzi kapena angapo amomwe omwewo omwe ali ndi mphamvu yothandizira thupi. Ndi ma analogi amatanthauza mankhwala okhala ndi zinthu zosiyanasiyana zogwira ntchito, koma zochizira matenda omwewo.

Kusiyana pakati pa matenda a ma virus ndi bakiteriya
Matenda opatsirana amayambitsidwa ndi ma virus, mabakiteriya, bowa ndi protozoa. Njira ya matenda oyambitsidwa ndi ma virus ndi ma bacteria nthawi zambiri imakhala yofanana. Komabe, kusiyanitsa chomwe chimayambitsa matendawa kumatanthauza kusankha njira yoyenera yomwe ingathandize kuthana ndi misala komanso sikuvulaza mwana.

Matalala ndi omwe amayambitsa chimfine
Anthu ena amadziwa zomwe zimachitika nthawi zambiri ngati mwana ali ndi chimfine. Makolo amamutengera kwa madotolo, kukamuyeza mayeso, kugwiritsa ntchito mankhwala osokoneza bongo, ndipo monga chotulukapo chake, mwana amalembetsa kale ndi dotolo wa ana monga nthawi zambiri amadwala. Zoyambitsa zenizeni za kupuma pafupipafupi sizidziwika.

Urology: mankhwalawa a chlamydial urethritis
Chlamydial urethritis nthawi zambiri imapezeka pochita urologist. Amayamba chifukwa cha majeremusi a chlamidia trachomatis, omwe ali ndi mphamvu ya mabakiteriya komanso mavairasi, omwe nthawi zambiri amafunikira njira yothandizira antibacterial. Imatha kuyambitsa kutupa kosakhudzana ndi urethra mwa amuna ndi akazi.

Kuwonetsedwa kwa matendawa ndi chithandizo chake?

Type 2 shuga mellitus angatchulidwe ndi zazikulu za m'zaka za zana la makumi awiri ndi limodzi. Njira yamakono yamoyo, kuthamanga kosalekeza komanso kupsinjika, ntchito yogwira ntchito limodzi ndi zakudya zopanda thanzi imakhala zifukwa zazikulu zachitukuko.

Chithandizo cha matenda a kagayidwe kachakudya zimagwiritsidwa ntchito zovuta, zomwe mankhwala apadera ndi kudya kwambiri amakhala. Dziwani kuti munthu amatha kumwa mankhwalawa momwe angafunikire, koma popanda chithandizo chamankhwala, zotsatira zabwino sizingatheke.

Mankhwala osankhidwa bwino amathandiza wodwala matenda ashuga kukhala ndi moyo wabwino komanso kupewa zovuta.

Zida zonse zamankhwala zomwe zimagwiritsidwa ntchito popanga zovuta zitha kugawidwa m'magulu otsatirawa:

1. Mapiritsi omwe amathandizira kapamba.
2. Mankhwala omwe amachotsa kukonzekera kwa insulin. Matenda oterewa nthawi zambiri amapezeka mwa anthu omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo ndipo ndi chiwonetsero cha kusazindikira mtima kwa minyewa yomwe imapangidwa ndi kapamba.
3. Mankhwala okhala ndi acarbose. Chifukwa cha gawo ili, pali cholepheretsa mayamwidwe m'matumbo.

Mankhwala omwe ali ndi phindu pa makulidwe a kapamba amaphatikizanso magome ochokera ku gulu la sulfonylureas ndi ma ironides.

Zosakanikirana zimachitika mothandizidwa ndi ma insretins. Mankhwala omwe amalepheretsa mawonetseredwe a insulin kukokana ndi mapiritsi otengera metformin kapena thiazolinedione.

Zomwe zili bwino kwa wodwala aliyense zitha kutsimikiziridwa ndi adotolo pamaziko a chithunzi chazachipatala ndi mawonekedwe a wodwalayo.

Pharmacological katundu wa mankhwala

Mankhwala Gliclazide anayamba kugwiritsidwa ntchito ngati mankhwala a matenda a shuga 2 molumikizana ndi mankhwala omwe adokotala adya.

Mankhwalawa samangoleketsa kukula kwa shuga m'magazi, komanso amathandizira kuchepetsa kuchepa kwa thupi, zomwe ndizofunikira kwambiri kwa anthu omwe ali ndi vutoli.

Mpaka pano, mawonekedwe ena a mankhwalawo adadziwika.

Zakhazikitsidwa zasayansi kuti munthu atha kutenga Glyclazide 80 mg kuti akwaniritse zolinga izi:

• Zimathandizira kuteteza ubongo ku obsolescence, womwe umakulolani kugwiritsa ntchito zolinga zake za prophylactic za matenda a Alzheimer's.
• Mosangalatsa zimakhudza chikhalidwe cha zotengera ndi mitsempha. Chifukwa chake, mothandizidwa ndi mankhwala, kukhazikika kwa atherosclerosis, kuchepa kwa mtima, matenda oopsa, kuletsa mtima kwamankhwala kumatha kupewedwa.
• Amachepetsa mwayi wokhala ndi khansa.
• Amagwira ntchito pofuna kukonza kuthekera kwa abambo omwe asokonezeka chifukwa cha matenda osiyanasiyana okalamba.
• Zimalepheretsa kukula kwa mafupa ndi matenda ashuga. Makamaka mafupa owundana nthawi zambiri amakhudza azimayi atayamba kusamba, popeza pali kuchepa kwakukulu kwamahomoni - estrogen.
• Chimakonda bwino chithokomiro cha chithokomiro.
• Imawonetsa ntchito yoteteza mokhudzana ndi dongosolo la kupuma.

Mankhwala Glyclazide amagwiritsidwa ntchito mwachangu kuchepetsa magazi. Nthawi yomweyo, kuchepa kwa zizindikiro kumachitika osati pambuyo pa chakudya chachikulu, komanso kumakupatsani mwayi kuti muchepetse maziko. Gawo lalikulu la mapiritsi limakupatsirani mwayi wopanga insulin ndi kapamba, yemwe amakhudza thupi ndipo samatulutsa chiwopsezo cha hypoglycemia. Kuphatikiza apo, zina mwazabwino ndi izi:

1. kulowerera kwa hyperinsulinomy,
2. zabwino kwambiri zochepetsa thupi,
3. amachepetsa chiopsezo cha matenda opatsirana ndi mtima,
4. zimakhudza kagayidwe kazida ka lipid m'thupi,
5. amachepetsa makutidwe ndi mafutawa,
6. Amachepetsa kuchuluka kwa cholesterol yoyipa,
7. amachepetsa chiopsezo cha matenda a shuga,

Imathandizira kutsika kwa triglycerides.

Malangizo ogwiritsira ntchito mankhwalawa

Gliclazide ya mankhwala imayikidwa pokhapokha ngati anthu achikulire ndi piritsi losinthika.

Ndikofunikira kumwa mankhwala otero motsogozedwa ndi kuyang'aniridwa ndi adokotala. Malangizo a Gliclazide ogwiritsa ntchito amakhalanso ndi chidziwitso chofunikira chokhudza kumwa mosamala.

Mankhwalawa atha kugulidwa ku malo azamankhwala azigawo munthawi zotsatirazi:

• 30 mg yogwira piritsi limodzi,
• 60 mg yogwira pophika
• 80 mg

Kutengera mlingo wake, malamulo omwera mankhwalawa amadalira. Njira ya mankhwalawa imafotokozedwa mu Mlingo womwe umachokera ku chithunzithunzi chachikulu cha matenda ndi mthupi la wodwalayo.

Chizindikiro chachikulu chomwe muyenera kulabadira posankha mlingo ndi kuchuluka kwa glucose m'magazi ndi gawo la kulemera kwa wodwala. Mlingo wa tsiku ndi tsiku sayenera kupitirira 120 mg ya chinthu chachikulu.

Pankhaniyi, njira yoyambira yovomerezeka iyenera kuyamba ndi Mlingo wa 30 kapena 60 mg. Mapiritsi amayenera kuledzera kamodzi patsiku, makamaka m'mawa. Ngati, pazinthu zina, mankhwala adasowa, palibe chifukwa chowonjezera mlingo wotsatira. Kuphatikiza apo, malangizo a boma akuti kuwonjezera kuchuluka kwa mankhwalawa ndikofunikira patatha mwezi umodzi atayamba kumwa mankhwalawo.

Chosiyana ndi odwala omwe, atatha maphunziro a masabata awiri, osawona momwe zinthu zilili komanso kuchuluka kwa shuga m'magazi nthawi zonse kumakhala kopitilira zizindikiro zake. Kenako, kuti mupeze zotsatira zabwino, adokotala angasankhe kuwonjezera kuchuluka kwake.

Tikutenga mankhwalawa, ndikofunikira kukhazikitsa kuwunika konseko kwamisempha yamagazi kuti hypoglycemia isachitike. Pofuna kupeza phindu kuchokera pakumwa mankhwalawo, nthawi zambiri njira yochizira imathandizidwa ndimankhwala otsatirawa:

• zochokera sulfonylurea,
• Glyclazide Metformin,
• insulin
• zoletsa
• zotengera thiazolidione.

Kutengera kampani yomwe ikupanga mankhwala, mtengo wa Gliclazide ungasiyane pang'ono. Mtengo wawo amathanso kukhudzidwa ndi kuchuluka kwa mankhwalawa (30 mg, 60 mg kapena 80 mg).

Ndemanga zambiri za odwala zikuwonetsa kupezeka komanso kuchuluka kwa mapiritsi.

Ndi zovuta zoyipa ziti zomwe zingachitike mutamwa mankhwalawa?

Chithandizo ndi chithandizo cha mankhwala ndi Glyclazide ziyenera kuchitika moyang'aniridwa ndi achipatala.

Sizovomerezeka kumwa mankhwalawa mu Mlingo wopitilira malangizo a dokotala, kapena molumikizana ndi mapiritsi ena osankhidwa ndi wodwalayo.

Njira yakugwiritsira ntchito ndi mlingo wake zikuwonetsedwa mu malangizo ochokera kwa wopanga.

Kusagwiritsa ntchito mankhwalawa mosayenerera kungayambitse mavuto ambiri, mankhwala owopsa a thupi la munthu atseguka.

Zowonetsa zazikulu za mankhwalawa zimaphatikizapo izi:

1. Mavuto ogaya, omwe amatha kutsagana ndi kubala, kupweteka m'mimba kapena m'mimba.
2. Zotsatira zosasangalatsa zachitsulo mkamwa zitha kuwoneka pambuyo povulala.
3. Kumva kwamphamvu njala.
4. Kusanza ndi kusanza.
5. Kuwonetsedwa kwa thupi lawo siligwirizana ndi chimodzi kapena zingapo za mankhwalawa.
6. Chizungulire ndi mutu.
7. Kutupa kosiyanasiyana pakhungu, mawanga kapena kutupira kwa minofu kumachitika.
8. Kuphwanya ziwalo zamasomphenya.
9. Maonekedwe a hypoglycemia.
10. Kukula kwa lactic acidosis.
11. Megaloblastic anemia.

Monga lamulo, Zizindikiro zotere zimazimiririka atayimitsa mankhwalawo. Tiyeneranso kudziwa kuti njira yolakwika ndi kuchuluka kwa mankhwalawa kungayambitse hypoglycemia.

Kodi mankhwala amaletsedwa liti?

Mankhwala ali ndi mndandanda wofunikira wa contraindication chifukwa chogwiritsa ntchito. Ndiye chifukwa chake, musanayambe maphunziro, muyenera kuwerenga malangizo mosamala.

Zotsatira zoyipa zilizonse zikachitika, muyenera kufunsa dokotala ndi kukambirana zina za mankhwalawa.

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pamaso pa zinthu ndi matenda:

• Zochizira mtundu 1 matenda a shuga, odwala insulin.
• Kukula kwa ketoacidosis, chikomokere kapena kholo la mtundu wa matenda ashuga.
• Njira zazikulu za pathological mu impso kapena chiwindi, komanso pamaso pa kusakwanira kwawo.
• Matenda ena a kupuma thirakiti, komanso pamene vuto la kupuma limachitika.
• Matenda a mtima ndi mtima, kulephera kwa mtima, kapena kulowerera kwamitsempha.
• Kukula kwa matendawa chifukwa cha matenda osiyanasiyana.
• Opaleshoni yaposachedwa komanso kuvulala.
• Madzulo komanso pambuyo poyeserera. Izi zikuphatikiza ma radiology, chifukwa wothandizira wosiyana ndi ayodini amagwiritsidwa ntchito.
• Lactic acidosis
• Kusalolera kapena Hypersensitivity gawo limodzi kapena zingapo za mankhwala,
• Pamaso pa kusowa kwamadzi,
• Kugwiritsa ntchito miconazole mosangalatsa.

Atsikana ndi amayi oyembekezera panthawi yoyembekezera amaletsedwa kutenga metformin, chifukwa mavuto osiyanasiyana ndi kukhazikika kwa mwana wosabadwayo angachitike. Ndi kufunikira kwakanthawi kwamankhwala, mkazi ayenera kusiya kuyamwitsa.

Kuphatikiza apo, ana osakwana zaka khumi ndi zisanu ndi zitatu ali pachiwopsezo.

Kodi ndizotheka kusintha mankhwalawa ndimankhwala ena?

Mankhwala Gliclazide, monga momwe akuwonera pakuwunikira wodwala, amaloledwa mosavuta ndipo amakhala ndi kuchepetsa shuga.

Mtengo wapakati ndi pafupifupi ma ruble 135.

Pali nthawi zina pamene m'malo mwake mankhwalawa akufunika. Mwanjira iyi, mutha kusankha ma analogi a Gliclazide kapena maimelo omwe msika wa pharmacological umapereka.

Mpaka pano, pali malo ena otere:

Diabetes ndi m'gulu la sulfonylureas la m'badwo wachiwiri. Ndemanga zachipatala zikuwonetsa kuti ngati mutenga Diabeteson kwa zaka ziwiri, palibe chitukuko cha kukana insulin.

M'mapangidwe ake, Diabetes ndi chithunzi chonse cha mapiritsi a Gliclazide. Njira makonzedwe a mankhwala zimatengera umunthu wodwala. Monga lamulo, ndi piritsi limodzi kapena awiri patsiku. Mtengo wapakati pa Diabeteson ndi ma ruble 330 pamapiritsi 30.

Metformin - ndi mankhwala ochokera ku kalasi ya biguanides, yomwe imagwiritsidwa ntchito mwachangu pochiza matenda amtundu wa 2 shuga. Chofunikira chachikulu cha mankhwalawa ndi metformin hydrochloride. Mtengo wamba mumafakisi ndi ma ruble 250.

Glidiab ndi mankhwala a hypoglycemic omwe ali ndi 80 mg yogwira ntchito. Mtengo wapakati pamsika ndi ma ruble 140 pa paketi (mapiritsi 60).

Diabefarm ndi piritsi lomwe limagwiritsidwa ntchito mosamala pochiza matenda amtundu wa 2 shuga. Mtengo wa mankhwalawa umakhala ma ruble 120. Kanema yemwe ali munkhaniyi amafotokoza zamomwe angapangire odwala matenda a shuga.