Captopril Sandoz ndi angiotensin wotembenuza enzyme inhibitor. Mwanjira ina, mankhwalawa amalepheretsa mtundu wachiwiri wa angiotensin kutembenuka kuchokera woyamba. Chifukwa chake, kuchepa kwakukulu kwa mahomoni a oligopeptide kumapangitsa kuthamanga kwa magazi kukhala kwazonse. Ndi muyezo woyenera, wodwalayo amateteza magazi osati magazi, komanso mphamvu yonse ya zotumphukira. Hypotensive zotsatira za mankhwala palokha popanda ntchito ya plasma renin. Odwala amakumana ndi kuchepa kwa kukakamizidwa ngakhale pazovuta za mahomoni. Imatha kupititsa magazi m'magazi a myocardium. Malinga ndi malangizo ogwiritsira ntchito, Captopril Sandoz amachepetsa kumamatira m'matumbo, amakhala ndi cholepheretsa kukula kwa mtima kulephera, komanso amachepetsa kwambiri kuwonjezeka kwa voliyumu yamanzere. Mankhwalawa amamwetsa msanga mokwanira ndi m'mimba. Zizindikiro izi ndizosachepera 75%. Odwala azikumbukira kuti kudya nthawi yomweyo ndi kumwa kumachepetsa mphamvu ya gawo lalikulu pafupifupi theka. Gawo lalikulu la zinthuzo limapukutidwa kudzera mu kugwira ntchito kwa impso ndipo gawo laling'ono lokha silinasinthe.

Captopril Sandoz amalembedwa ndi dokotala wokhazikika, atatha mayeso onse ofunikira. Amapangidwira odwala omwe ali ndi matenda angapo otsatirawa: • kuthamanga kwa magazi, • kukonzanso kwamitsempha yamagazi, chomwe chimayambitsa kuchepa kwamitsempha kapena nthambi zake, • kusokonezeka kwamitsempha yamanzere, yomwe imalumikizidwa ndi myocardium yapitayi, • kuwonongeka kwa impso chifukwa chokhazikitsidwa wapezeka ndi matenda a shuga, • wodwala mtima. Ndikofunika kudziwa kuti mankhwalawa apezeka kuti anthu ambiri amagwiritsa ntchito osati chithandizo chokhacho, komanso monga gawo la chithandizo chovuta. Odwala ayenera kumvetsetsa kuti ngati simukugwirizana ndi thanzi lanu labwino, ndiye kuti matenda oopsa a banal angapereke zovuta kwambiri. Kusintha kwa khungu komanso kusokonekera kwake kumapangitsa munthu kuti akhale wakhungu. Kuzungulira kwa cerebral kumavulaza kwathunthu, ntchito yamtima imawonongeka kwambiri, zomwe zimachulukitsa kufa kwa anthu osachepera kasanu. Kuwonjezeka kwa shuga m'magazi kumakhudza mitsempha, yomwe imakhala yovuta kwambiri kubwezeretsa. Kuwonongeka kwa impso kumachitika tsiku lililonse ndi kuthamanga kwa magazi.

Mawonekedwe ndi mawonekedwe a mankhwalawa

Chofunikira chachikulu pa Captopril Sandoz ndichinthu chomwe chimadziwika ndi dzina lomweli. Zowonjezera zomwe zimapangidwa ndizophatikizira ndi microcrystalline cellulose, wowuma wa mbatata, lactose monohydrate, komanso stearic acid. Zogulitsa zaku Germany zimangopezeka pafomu yamapiritsi pamsika wamankhwala. Chigawo chilichonse chili ndi mawonekedwe ozungulira komanso osalala, kutengera mtundu, imatha kukhala yamtundu kapena masamba anayi. Phaleli linapakidwa utoto loyera ngati chipale. Wovala yunifolomu mumithunzi, osati kumtunda kokha, komanso gawo. Kumbali ina, pamakhala chiopsezo chophweka. Mankhwala ochepetsa ululu akupezeka mu kuchuluka kwa 6.25 mg, 12,5 mg, 25 mg, 50 mg ndi 100 mg. Chowonadi choterocho chimapangitsa kuti kusakhale kosavuta kusintha kwa tsiku ndi tsiku kwa odwala. Piritsi lirilonse limapezeka mu cell ya contour yopangidwa ndi zojambulazo. Chithuza chilichonse chimakhala ndi magawo khumi. Makatoni amakhadi akhoza kukhala ndi maselo amodzi mpaka khumi.

Contraindication

Mankhwala aliwonse, ngakhale amagwiritsidwa ntchito bwanji, alibe mndandanda wazomwe akuwonetsa, komanso akuwunikira omwe amaletsa maphunziro. Malangizo ogwiritsira ntchito Captopril Sandoz akuti mankhwalawa sanalembedwe kwa odwala omwe ali ndi matenda otsatirawa: • tsankho lomwe limaperekedwa palimodzi mwazomwe zimapangidwira, komanso hypersensitivity, • mitundu yosiyanasiyana yokhudza thupi, kuphatikizira angioedema, yowonetsedwa m'dera lalikulu la khungu , • kuchuluka kwa michere ya nitrogenous m'magazi, yowonjezera kudzera mu impso, • kuchuluka kwa potaziyamu m'magazi, • pang'ono kapena kufupika kwa mitsempha yamkamwa, mkamwa Ndili ndi aorta, mitral valve kapena impso, • pakuchira pambuyo pakupatsirana kwa impso, • ma syndromes azachipatala omwe amayamba chifukwa chopanga kwambiri aldosterone, • kukhalapo kwa kutsekeka kwa kutuluka kwa magazi kuchokera kumanzere kwamitsempha, • kuthamanga kwa magazi, • kupindika kwa myocardial infarction, yomwe Nthawi zambiri imapha, • munthawi yomweyo kugwiritsa ntchito mankhwalawa pogwiritsa ntchito mankhwala osokoneza bongo a aliskiren. Ngati wodwala ali ndi vuto lililonse kuchokera pamndandanda womwe uli pamwambapa, adokotala amafotokozera analogue osalephera.

Malinga ndi kafukufuku wazachipatala zambiri, Captopril Sandoz amayenera kutengedwa ola limodzi asanadye. Ndikwabwino kusatafuna mapiritsi ndi kumwa madzi oyera ambiri. Mlingo wofunikira pa vuto linalake uyenera kupangidwa ndi akatswiri azachipatala omwe ali ndi mbiri yoyenera. Pali mtundu wina wa mankhwala wopangidwa ndi wopanga. Ndi bwino kuti wodwalayo ayambe maphunzirowa ndi muyezo wa 12,5 mg. Kulandila kumachitika kawiri patsiku. Wodwala atatha kumwa koyamba, dokotala amayenera kuwunika mosamala mu ola loyamba. Ngati munthu akumva bwino, mulibe zotsutsana kuti mugwiritsenso ntchito. Mankhwala othandiza kwambiri, dokotala nthawi yamankhwala amatha kusintha Mlingo watsiku ndi tsiku komanso mbali imodzi. Kwa odwala omwe amafunikira chithandizo chofatsa komanso chothandizira, ndikoyenera kumwa 25 mg nthawi imodzi. Mlingo wambiri watsiku ndi tsiku mu nkhani iyi sayenera kupitilira 50 mg. Ngati ndi kotheka, adotolo amawonjezera mpaka 150 mg, omwe amagawidwa pazidutswa zitatu tsiku lonse. Odwala omwe ali ndi vuto la mtima ayenera kuthandizidwa mosamala kwambiri komanso mothandizidwa ndi adokotala. Pachikhalidwe, ndi matenda omwewo, adokotala akuwonetsa kuti ayambe kulandira mankhwala a 625 mg. Ndi zoyeserera zabwino komanso kusakhalapo kwa zoyambitsa, mankhwalawa amatha kusintha.

Zotsatira zoyipa

Musanayambe mankhwala othandizirana ndi mankhwalawa, muyenera kudziwa bwino za zovuta zomwe zingakumane ndi wodwalayo. Zachidziwikire, Captopril Sandoz ndi chizindikiro cha chitukuko chamakono ndi ukadaulo. Komabe, pali ziwonetsero zingapo: m'magazi, • kuphwanya kugona osati kokha, komanso masamba omwe akumva kukoma, limodzi ndi migraines, kugona, chizungulire, madera ovuta, • odwala amatha kudwala matenda okomoka, kukomoka, ndi mikwingwirima, • kuwawa kwamtima, kupweteka kwa nthawi yayitali komanso nthawi yayitali ya mtima, kuphatikizidwa ndi kutentha kwa nkhope, kapena mosemphanitsa, ndi kupindika kwa edema, • chifuwa chowuma popanda kutuluka kwa sputum, chibayo, kufupika , • kusakhazikika pamimba mu mawonekedwe a mseru, ndi kulemera, • kuphwanya pafupipafupi kwa chopondapo, • kuwoneka kwa zilonda zazing'onoting'ono pakatikati kamatumbo ndi lilime. Ngati wodwala, popanda chidziwitso cha dokotala, wachulukitsa mlingo wa tsiku ndi tsiku, ndikofunikira kuchita zofunikira pakuchotsa m'mimba mwachangu, perekani zakumwa zilizonse ndikuwuzani othandizira.

Kuyanjana kwa mankhwala

Musanagule Captopril Sandoz, muyenera kumvetsetsa kuti mankhwalawa si "ochezeka" mwanjira zonse. Mankhwala otero a gulu la zoletsa sayenera kutengedwa kuti atenge nthawi imodzi ndi mankhwala omwe amakhudza dongosolo la renin-angiotensin mthupi la munthu. Kumbukirani kuti kusinthasintha koteroko kumatha kupangitsa wodwala kuchepa magazi komanso kuwonongeka kwambiri kwaimpso. Kuvomerezedwa munthawi yomweyo kumaloledwa, koma pokhapokha pakuyang'aniridwa ndi adokotala. Gwiritsani ntchito ndi aliskiren tikulimbikitsidwa kuti kupewe odwala omwe ali ndi vuto la impso, komanso matenda amtundu wa 2. Kuphatikiza kosiyanasiyana kwa potaziyamu kuyenera kupewedwa. Kutsegula kotereku kumatha kupangitsa kuti munthu aziwoneka kuti ali ndi vuto lalikulu. Ngati kuphatikiza uku sikungapewedwe, pamenepa wodwalayo amayenera kuyang'aniridwa ndi dokotala nthawi yonseyi, akumadutsa mayeso onse ofunikira. Mankhwala ophatikiza ndi Lithium amasungidwa m'thupi, motero amawonjezera kuphatikizidwa kwa gawo lalikulu m'magazi a anthu.

Malangizo apadera

Captopril Sandoz ndi mankhwala oopsa, omwe ayenera kufikiridwa ndi chikumbumtima chomwecho. Ndikofunika, musanayambe maphunzirowa, kuwunikira kupanikizika kwa masabata angapo motsatizana kuti mumvetsetse malire ndi momwe zinthu zina zingawonekere. Chithunzi chofananira ndichofunika kwambiri pakulandila chithandizo. Gawo lalikulu la kapangidwe kameneka lingayambitse chidziwitso chabodza mukamadutsa mkodzo ku acetone. Pankhaniyi, ndikofunikira kusiya kuyitenga ndipo pakatha masiku angapo kuti mubwereze mayeso. Munthawi yonse ya njira yochizira, wodwalayo ayenera kusiyiratu kuyendetsa galimoto, komanso zochitika zosiyanasiyana zomwe zimafunikira chidwi kwambiri. Kuwunikira mosamala kumayeneranso odwala omwe akudwala matenda opatsirana minofu, komanso kukhalapo kwa njira zotupa pamakoma amitsempha yamagazi. Ndi zizindikiro zilizonse zokayikitsa, zotsatira za mankhwalawa ziyenera kuthetsedwa posachedwa ndipo zina zofananira ziyenera kusankhidwa.

Kumasulidwa mafomu ndi kapangidwe

Amapezeka m'mapiritsi, ali ndi izi:

• mawonekedwe ake ndi ozungulira kapena ofanana ndi masamba anayi.
• mtundu woyera
• padziko lapansi
• chiwopsezo cha mtanda.

Zimapangidwa ndizosiyanasiyana pazoyambira. Maunitsi amasulidwe, omwe ali pa 6.25, 12,5, 100 mg, ali ndi mawonekedwe ozungulira. Mwanjira yokhala ndi masamba anayi, mafomu okhala ndi 50 ndi 25 mg pazomwe zimagwira.

Atadzaza matuza kwa 10 mayeso. Amamasulidwa m'matumba a makatoni. Malangizowo akuphatikizidwa.

Chigawo chilichonse chomasulidwa chimakhala ndi yogwira pophika ndi zosakaniza zothandizira. Kapangidwe kazinthu zina:

• wowuma chimanga
• lactose monohydrate,
• cellcrystalline mapadi,
• stearic acid.

Mulibe mankhwala osokoneza bongo, imapereka chofunikira chothandizira.

Captopril Sandoz

Captopril Sandoz: malangizo ogwiritsa ntchito ndi kuwunikira

Dzina lachi Latin: Captopril Sandoz

Code ya ATX: C09AA01

Zogwira pophika: Captopril (Captopril)

Wopanga: Salutas Pharma, GmbH (Salutas Pharma, GmbH) (Germany)

Kusintha malongosoledwe ndi chithunzi: 07/12/2019

Mitengo muma pharmacies: kuchokera ku ma ruble 81.

Captopril Sandoz ndi mankhwala osokoneza bongo a antihypertensive, angiotensin otembenuza enzyme (ACE) inhibitor.

Gulu la mankhwala

Arterial hypertension (mono- ndi kuphatikiza mankhwalawa), mtima wosakhazikika, mtima, kumanzere kwamitsempha yamagazi m'magazi okhazikika pambuyo poyambitsa matenda amiseche, nephropathy ya matenda ashuga odwala matenda a shuga osaposa 30 mg / tsiku).

Gwiritsani ntchito mu ukalamba

Kwa anthu omwe msinkhu wawo umaposa zaka 60-65, maphunzirowa ayenera kuyamba ndi mlingo wa 6.25 mg kawiri patsiku. Mtengo wa Captopril Sandoz ndi ma ruble 100. Mutha kugula mankhwalawa kudzera paupangiri wathu pa intaneti ndikupereka kunyumba kwanu kapena ku ofesi. Amatulutsidwa pokhapokha paphikidwe.

Chilolezo cha Pharmacy LO-77-02-010329 cha pa June 18, 2019

Pharmacological kanthu

Ili ndi tanthauzo lotsogolera. Imalepheretsa kaphatikizidwe ka yogwira angiotensin II vasoconstrictor ku hemodynamically ofooka angiotensin I. Amachepetsa kubisika kwa aldosterone.

Imalimbikitsa kukonzekera kwa bradykinin, yomwe imakhudza kapangidwe ka vasodilating prostaglandins.

Kugwiritsa ntchito nthawi yayitali kumakhala ndi zotsatira zamtima:

• Imachepetsa isanafike komanso pambuyo pake,
• Ikuyenda bwino kwa magazi a ischemic maboni a myocardium,
• kumawonjezera nkhokwe,
• Imachepetsa kupangika kwa hypertrophy, kuchepa kwa mpweya wamanzere,
• amatanthauzira diastolic ntchito.

Sichimayambitsa Reflex tachycardia. Imalimbitsa magazi othamangitsana, imachepetsa kuphatikizika kwa ma cell.

Mlingo wokwanira wa mankhwalawa chifukwa cha kulephera kwa mtima sayambitsa kusinthasintha kwa magazi. Thandizani kuwonjezera kuchuluka kwa miniti, kukulitsa kulolera kochita masewera olimbitsa thupi.

Mopanda tsankho. Ili ndi potaziyamu-woteteza. Zimakhudzanso insulin sensitivity.

Ili ndi nephroprotective kwenikweni. Kuchepetsa mphamvu ya impsontere amathandizira kuchepetsa kukakamira kwa mphamvu. Imalepheretsa kuphatikizika kwa mitsempha yambiri, imagwirizanitsa kapangidwe ndi ntchito ya epithelium.

Zochita za renin-angiotensin zimalengeza kukula kwa thupi poyambanso kumwa mankhwalawo.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mankhwala amapezeka mu mawonekedwe a mapiritsi: oyera, okhala ndi mawonekedwe ofanana, ozungulira, mlingo wa 6.25 mg - biconvex, mlingo wa 12,5 mg - convex kumbali imodzi, mbali inayo, wogawa chiopsezo, Mlingo wa 25 ndi 50 mg - mu mawonekedwe a masamba anayi. wokhala ndi chamfer komanso mawonekedwe owopsa pammbali mbali ziwiri, mulingo wa 100 mg - mbali imodzi imakhala yodziwika bwino, inayo imakhala ndi chiopsezo cha mtanda (10 m'matumba, pamatabwa a 1, 2, 3, 4, 5 kapena 10 ndi malangizo ogwiritsidwa ntchito ndi Paptopril Sandoz).

Piritsi limodzi lili:

• yogwira mankhwala: Captopril - 6.25, 12.5, 25, 50 kapena 100 mg,
• othandizira zigawo: lactose monohydrate, wowuma chimanga, cellcrystalline cellulose, stearic acid.

Mankhwala

Mankhwala ali mwachindunji kwachilengedwe. Zisakhudze machitidwe a minye renin-angiotensin. Mphamvu ya hemodynamic imalumikizidwa ndi vasodilation, sizitengera kuchuluka kwa renin m'magazi.

Captopril Sandoz amatchulidwa kuti ndi gawo la zovuta kuchitira matenda oopsa.

Kuchotsa msanga. Kukhazikika kwa zochita kumadziwika pambuyo pa mphindi 30. Bioavailability wa mankhwalawa ndiwambiri. Kukonzekera kwa pakamwa kumapereka zotsatira zambiri pambuyo pa ola limodzi. Kutalika kwa kuchitapo kanthu kuchokera pa maola 4 mpaka 12.

Zimapangidwa m'chiwindi, ndikupanga metabolites. Wosangalatsa ndi impso. Gawo limodzi la mankhwala limapukusidwa kuchokera mu thupi. Itha kudziunjikira vuto laimpso. Hafu ya moyo wotere umakula tsiku limodzi ndi theka.

Mankhwala

Captopril imathandizira kuchepetsa kupanga kwa mahomoni a angiotensin II kuchokera ku angiotensin I, omwe amachepetsa kutulutsidwa kwa aldosterone. Izi zimabweretsa kutsika kwa kuthamanga kwa magazi ndi katundu pa minofu ya mtima.

Mothandizidwa ndi mankhwalawa, magazi amayenda m'mitsempha yamagazi ndi aimpso. Odwala omwe amamwa mankhwalawa kwa nthawi yayitali, magazi myocardial amayamba.

Mankhwala amachepetsa chiopsezo chokhala ndi matenda a shuga.

Zomwe zimathandiza

Nthawi zambiri amatchulidwa ngati gawo la zovuta chithandizo cha matenda otsatirawa:

• matenda oopsa
• matenda ashuga nephropathy,
• kulephera kwa mtima,
• pachimake coronary thrombosis.

Monga monotherapy imagwira ntchito poyambira magawo a matenda oopsa, kumatha popanda zovuta.

Contraindication

Contraindated mu mimba, yoyamwitsa. Sikugwiritsidwa ntchito mwa ana ochepera zaka 18.

Simungathe kugwiritsa ntchito mankhwalawa ndi:

• mbiri ya angioedema yoyambira kulikonse,
• Hypersensitivity kwa okakamira zinthu kapena mankhwala ena a gululi,
• matenda a seramu
• mayikidwe
• lactose tsankho, kufupika kwa lactase m'thupi,
• Mgwirizano wamitsempha wamagazi wamanjenje kapena sttery ya minyewa imodzi.

Wothandizila chifukwa chopsa sangathe kugwiritsidwa ntchito pambuyo pothana ndi impso.

Captopril sagwiritsidwa ntchito mwa ana ochepera zaka 18.

Ndi chisamaliro

Chenjezo liyenera kuchitika mu matenda otsatirawa:

• hypertrophic obstriers cardiomyopathy,
• matenda ashuga
• scleroderma, systemic lupus erythematosus,
• mitral valavu stenosis, machitidwe orortice,
• hypovolemia
• chiwindi ndi kulephera kwa impso.

Popereka mankhwala, muyenera kuganizira kugwiritsa ntchito zakudya zopanda mchere, zopatsa thanzi.

Mlingo wothandizila ndi munthu payekha. Ndi matenda a impso, ndikofunikira kuyang'ana kuzidziwitso za creatinine clearance. Zikatero, Mlingo wogwira ntchito bwino umagwiritsidwa ntchito, nthawi yayitali pakati Mlingo.

Pa kukakamizidwa

Ndikofunikira kuyamba ndi mankhwalawa pogwiritsa ntchito mlingo wochepetsetsa, kuwongolera kulekerera kwa mlingo woyamba. Perekani 12.5 mg kawiri pa tsiku. Kukula kwapang'onopang'ono kwa mlingo kumalimbikitsidwa kuti mukwaniritse zomwe mukufuna. Odwala okalamba amapatsidwa mlingo woyenera wa mankhwalawa.

Matenda osalephera a mtima, musanayambe chithandizo, okodzetsa amathetsedwa kapena mlingo wawo umachepetsedwa.

Pansi pa lilime kapena chakumwa

Njira yothira mankhwalawa imatsimikizika mwakukula kwa vutoli. Ndi chithandizo chomwe mwakonza, mankhwalawa amayenera kumezedwa kwathunthu, kutsukidwa ndi madzi okwanira.

Panthawi yamavuto, mankhwala ochepa amaloledwa.

Zochita za mankhwala zimachitika mwachangu, pakatha mphindi 30. Kuchuluka kwakukulu ndi kukonzekera kwa pakamwa kumawonedwa mu ola loyamba.

Pharmacokinetics

Pafupifupi 75% ya captopril imayamwa kuchokera kumatumbo am'mimba m'nthawi yochepa. Koma ngakhale kumwa mapiritsi ndi chakudya, mayamwidwe amachepetsa pafupifupi 30-40%. Kuchuluka kwazinthu zofunikira m'magazi kumawonedwa pambuyo pa maola 0.5-1,5 mutatha kumwa mankhwalawo.

Mankhwala zimapukusidwa mu chiwindi. Hafu ya moyo ndiyosakwana maola atatu. Nthawi ino imachulukitsidwa kwa odwala omwe ali ndi vuto la impso.

Zomwe zimathandiza

Captopril imagwiritsidwa ntchito pozungulira matenda oopsa. Musanayambe kumwa mankhwalawa, ndikofunikira kuti mudziwe zomwe zimayambitsa kukanikiza. Nthawi zambiri matendawa amakhala ndi matenda ena, chifukwa chake simuyenera kumadziyesa. Mankhwala ayenera kuikidwa ndi dokotala. Kugwiritsa ntchito mankhwalawa kumatheka pa gawo lililonse la matenda oopsa.

Captopril monga gawo la zovuta mankhwala amamulembera mtima kulephera kwina. Mankhwala akuwonetsedwa kwa kusowa kwamitsempha yamagazi, komwe kumayambitsidwa ndi myocardial infarction. Mitundu yoyamba ya odwala matenda ashuga a mtundu wa matenda a shuga nawonso amalangizidwanso kumwa mankhwalawa.

Ziwalo za hematopoietic

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumayendetsedwa ndi chitukuko cha neutropenia, thrombocytopenia, ndi kuchepa kwa hemoglobin. Izi zimachitika kawirikawiri, sizimangochitika zokha.

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumayendetsedwa ndi kuchepa kwa hemoglobin. Izi zimachitika kawirikawiri, sizimangochitika zokha.

Pa khungu

Kumwa mankhwalawa nthawi zambiri kumayendetsedwa ndi kuyabwa khungu, kuwoneka ngati zotupa. Kugwiritsa ntchito mankhwala kwa nthawi yayitali kumayambitsa kukula kwa lymphadenopathy. Zomwe zimakonda kwambiri ndi dermatitis ndi urticaria.

Pali chiopsezo chotukula Quincke edema. Maonekedwe a angioedema mu larynx amawopseza mpweya wabwino. Mankhwalawa amathetsedwa, epinephrine amaperekedwa nthawi yomweyo, ndipo mpweya umapezeka mosavuta.

Mukamayendetsa ndege, muyenera kupewa kuyendetsa magalimoto.

Malangizo apadera

Kuchita mankhwala kumafuna kuwunika pafupipafupi magawo a hemodynamic ndi ntchito ya impso.

M'pofunika kuganizira momwe mungakhalire hypovolemia mukamagwiritsidwa ntchito limodzi ndi okodzetsa. Zofanana ndi izi zimawopseza ndi mavuto owopsa a mtima, ngakhale kufa.

Kupewa kukula kwa zovuta kumathandiza:

• kusintha kwa mlingo
• kuyimitsidwa koyambirira kwa okodzetsa,
• masanjidwewo hemodynamic magawo.

Mitsempha yam'mimba imayambitsa kukoka kwa mankhwalawa, kuwunika kwamikodzo.

Proteinuria mukamagwiritsa ntchito milingo yayikulu imachepetsedwa kapena imapita yokha.

M'pofunika kupewa nthawi yomweyo makonzedwe a mankhwala okhala ndi potaziyamu.

Mosamala analamula kuti zolumikizana minofu matenda, immunosuppressation. Ndikofunikira kuwongolera zomwe zili m'maselo oyera ndi maselo ena amwazi.

Kuwunikira pafupipafupi kuchuluka kwa shuga m'magazi kumafunika.

Kukula kwa cholestatic jaundice, kuwonjezereka kwa gawo la hepatic transaminases kumafuna kuchotsedwa kwa mankhwalawa.

Kuchiza ndi mankhwalawa kuyimitsidwa tsiku lisanayambike opaleshoni yokonzekera.

Pa nthawi yapakati, captopril sangathe kugwiritsidwa ntchito.

Kuyenderana ndi mowa

Kuchita ndi zakumwa zoledzeretsa kumawonjezera mphamvu ya antihypertensive ya mankhwala, zomwe zimayambitsa kuphwanya kwa magazi kwa ziwalo ndi minofu. Zofanana zimawopseza kukula kwa zotupa zam'mimba.

Kugwiritsa ntchito zakumwa zoledzeretsa kumathandizira kuti potaziyamu wachotse thupi mosavuta, kumatha zotsatira zabwino za mankhwalawa pamisempha yamtima.

Mowa umathandizira kuchepa kwamitsempha yamagazi, umakhala ndi poizoni. Mwina kukula kwa orthostatic kugwa.

Bongo wa Captopril sandoz

Kumwa Mlingo waukulu wa mankhwalawa kumayambitsa kusokonezeka kwa ziwalo, ndikuopseza moyo. Kutsika kowopsa pantchito ya kupopa kwa mtima kumayendetsedwa ndi kukomoka kwa gawo lamanzere, kutsika kwa hemodynamics, ndi kukhazikika kwa boma. Zizindikiro zakulephera kwa impso zimawonekera.

Izi zimafuna chithandizo chamankhwala mwadzidzidzi. Ndikofunikira kutsuka m'mimba. Apatseni amatsenga. Bwezeretsanso magazi, chitani mankhwala ogwirira ntchito.

Kugwiritsira ntchito kolumikizana ndi okodzetsa kungayambitse kukula kwa hypotension, kuchepa kwa seramu potaziyamu, ndi hypovolemia.

Mogwirizana ndi mankhwala ena

Kugwiritsira ntchito kolumikizana ndi okodzetsa kungayambitse kukula kwa hypotension, kuchepa kwa seramu potaziyamu, ndi hypovolemia.

Kugwiritsira ntchito kukonzekera kwa potaziyamu, zowonjezera zakudya zimagwirizanitsidwa ndi chitukuko cha hyperkalemia ndi zovuta zamagulu a impso.

Hypotension yayikulu imayamba chifukwa cha mankhwala omwe amagwiritsidwa ntchito ngati opaleshoni.

Ndizosatheka kuphatikiza kulandila ndi Aliskiren ndi zoletsa zina za ACE.

Kugwiritsa ntchito Allopurinol kumabweretsa kuwoneka kwa neutropenia, kumawonjezera chiopsezo cha zovuta zoyipa.

Kutsitsa kwa mankhwalawa kumapangidwira ndi beta-blockers, othandizira calcium, ma nitrate, mapiritsi ogona, antipsychotic.

Mankhwala amawonjezera kuchuluka kwa digoxin m'magazi.

Pali chiopsezo cha hypoglycemia mukamayanjana ndi othandizira a hypoglycemic.

Imachepetsa kuchotsedwa kwa kukonzekera kwa lifiyamu, ndikuwonjezera ndende yawo ya plasma.

Mukamalumikizana ndi kukonzekera golide, zotsatirapo zake zimakhala zabwino.

Indomethacin, ibuprofen amachepetsa mphamvu ya mankhwalawa. Kusintha kofananako kumadziwika ndi kugwiritsa ntchito estrogen, njira zakulera zamkamwa, corticosteroids.

Gwiritsani ntchito ma antacid ndipo chakudya chimachepetsa kukhudzana kwa mankhwalawa ndi 40%.

Bongo

Ngati malingaliro a dokotala samatsatiridwa, bongo wa Captopril ndiwotheka, womwe umadziwika ndi zizindikiro zotsatirazi:

• Kutulutsa kuchepa kwa magazi,
• myocardial infaration,
• ngozi yamatenda,
• thromboembolism ndi zovuta zake.

Wodwala amafunikira chithandizo chamankhwala.

Migwirizano ndi magwiritsidwe akusungidwa

Mankhwalawa amagwiritsidwa ntchito zaka ziwiri kuyambira tsiku lomasulidwa. Tsiku lofananalo limapezeka pamapaketi a mankhwalawo. Koma kuti tisunge mankhwala omwe mankhwalawo amapezeka, amafunika kupereka malo osungirako olondola: chipinda chowuma chopanda kutentha kwa mpweya osaposa +25 ° C.

Terms a Tchuthi cha Pharmacy

Ichi ndi mankhwala omwe mumalandira.

Phukusi lokhala ndi mapiritsi 20 limawononga pafupifupi 90 ma ruble.

Irina Zinovieva, wazaka 57, Novocherkassk: "Ndakhala ndikudwala matenda othala magazi kwa nthawi yayitali, choncho ndinayesera mankhwala ambiri okhudzana ndi matenda am'mbuyomu, ndikudziwanso Katopril Sandoz. Mankhwala amachepetsa kuthamanga kwa magazi, koma samalekeredwa bwino ndi thupi. Nditamwa mapilitsi, mutu wanga unayamba kupweteka komanso kumva kuti ndikuyamba chizungulire, ndipo kamwa yowuma inatuluka. Ndiotsika mtengo, koma sindikukulangizani kupulumutsa thanzi lanu. Sindipangira mankhwalawa kwa aliyense. ”

A Maria Kushnareva, azaka 49, Novosibirsk: "Kamodzi kuntchito, kwa mwezi umodzi panali vuto. Kupanikizika pafupipafupi. Mnzake adalangiza kuti atenge Captopril. Thanzi langa linasintha nthawi yomweyo nditangomvera. Panalibe zotsatirapo zoyipa, ngakhale mnzake anachenjeza kuti pakhoza kukhala kugona kapena china chake. Mankhwalawa ndi otsika mtengo, ndipo amathandiza bwino kuposa mankhwala ambiri okwera mtengo. Ndikupangira. "

Zizindikiro zogwiritsidwa ntchito

• ochepa matenda oopsa
• Kukonzanso kwamphamvu kwamphamvu
• Kulephera kwamtima kosalekeza - monga gawo la zovuta mankhwala,
• kukanika kwa kumanzere kwamitsempha yamagetsi pakukhazikika kwakhalidwe pambuyo pakuwonekera m'maso,
• matenda ashuga nephropathy odwala mtundu 1 matenda a shuga (ndi albinuria oposa 30 mg / tsiku).

Mimba komanso kuyamwa

Kugwiritsa ntchito kompyuta ya Saptopz ya Captopril kumapangidwa panthawi ya gestation ndi mkaka wa m`mawere.

Mukakonzekera kutenga pakati, kutenga ACE zoletsa (kuphatikiza capopril) kuyenera kusiyidwa ndikusinthira njira ina yothandizira antihypertensive yokhala ndi mbiri yokhazikika yachitetezo.

Ngati kutenga pakati kumachitika panthawi ya chithandizo, muyenera kusiya kumwa Captopril Sandoz ndikuwonetsetsa kuti wodwalayo amayang'aniridwa pafupipafupi kuti akule. Izi zimaphatikizidwa ndi chiopsezo chowonjezereka cha vuto lobadwa nalo kwa mwana wosabadwayo mukamagwiritsa ntchito mankhwalawa mu nthawi yoyambirira ya mimba.

Amayi azaka zoyenera kubereka ayenera kudziwitsidwa za chiopsezo chachikulu cha mankhwala ndi zoletsa za ACE panthawi yoyembekezera yomwe imakhudzana ndi matendawa ndi kufa kwa mwana wosabadwa ndi / kapena wakhanda. Kugwiritsidwa ntchito kwa nthawi yayitali kwa capopril mu ma trimesters achi II ndi III kumatha kuyipa kwa mwana wosabadwayo, kumapangitsa oligohydramnios, kuyimitsidwa kwa impso, ndikuchedwa kufupikitsa mafupa a chigaza. Mwa makanda, amatha kuwonekera mu kulephera kwa impso, ochepa hypotension, hyperkalemia.

Mu mkaka wa m'mawere, pafupifupi 1% ya mlingo wa Captopril amapezeka.

Ndi mkhutu aimpso ntchito

Kugwiritsa ntchito Captopril Sandoz kumakhudzana kwambiri ndi kuwonongeka kwa impso, mayiko awiri a impso a artery stenosis kapena artery stenosis a impso imodzi yokhala ndi azotemia, hyperkalemia, azotemia, komanso mawonekedwe a kupatsirana kwa impso.

Chenjezo liyenera kuchitika mosalephera aimpso kulephera, a stenosis am'mitsempha, kapena stenosis yamitsempha yama impso imodzi.

Captopril Sandoz dosing regimen imakhazikitsidwa poganizira QC.

Njira zopewera kupewa ngozi

Chithandizo chikuchitidwa moyang'aniridwa ndi achipatala pafupipafupi. Asanalandire chithandizo (sabata 1), chithandizo cham'mbuyomu cha hypotensive chiyenera kusiyidwa. Odwala omwe ali ndi vuto loopsa la matenda oopsa, mankhwalawa amawonjezeka pang'onopang'ono maola 24 aliwonse mpaka mphamvu yayikulu itakwaniritsidwa motsogozedwa ndi kuthamanga kwa magazi. Pa mankhwala, kuwunika kuthamanga kwa magazi, chithunzi cha magazi oyamba (musanalandire chithandizo, m'miyezi itatu yoyambirira ya chithandizo komanso nthawi zina pambuyo pake mpaka chaka 1, makamaka kwa odwala omwe ali ndi chiopsezo cha neutropenia), kuchuluka kwa mapuloteni, potaziyamu, plasma potaziyamu, urea nayitrogeni ndikofunikira , creatinine, ntchito ya impso, thupi, chakudya. Ndi chitukuko cha hyponatremia, kuchepa madzi m'thupi, kusintha kwa mankhwalawa. Kuphwanya kwa maculopapular kapena urticaric (pocheperapo) kumachitika pakatha milungu 4 yoyambirira ya mankhwalawa, kutha ndi kuchepa kwa Mlingo, kusiya kwa mankhwalawa komanso kuyambitsa ma antihistamines. Mlingo wokhazikika womwe umadalira patatha miyezi itatu itangoyamba kumene chithandizo (kuchepa kwakukulu kwa chiwerengero cha leukocytes kumawonedwa mkati mwa masiku 10-30 ndipo kumapitirira pafupifupi masabata awiri atachotsa mankhwalawa). Kudwala (kawirikawiri kumawonedwa mwa azimayi) kumawonekera pafupipafupi sabata yoyamba (kuyambira maola 24 mpaka miyezi ingapo) yamankhwala, kumakhalabe pakumwa, ndikuyimitsa masiku angapo kumapeto kwa chithandizo. Kuphwanya kukoma ndi kuchepa thupi kumatha kusintha ndikubwezeretsanso pambuyo pa miyezi iwiri ya chithandizo. Chenjezo limafunikira pochita opaleshoni yothandizira (kuphatikizapo mano), makamaka mukamagwiritsa ntchito mankhwala oletsa kupanikizika omwe ali ndi vuto lotsogolera. Ndi chitukuko cha cholestatic jaundice ndi kupitilira kwathunthu kwa chiwindi necrosis, chithandizo chikuyenera kutha. Ndikofunikira kupewa hemodialysis kudzera pamatumbo apamwamba kwambiri opangidwa ndi polyacrylonitrile metaallyl sulfate (mwachitsanzo, AN69), hemofiltration kapena LDL-apheresis (anaphylaxis kapena anaphylactoid reaction). Hypersensitizing mankhwala angakulitse chiopsezo cha anaphylactic. Ndikulimbikitsidwa kupatula kumwa zakumwa zoledzeretsa pamankhwala. Gwiritsani ntchito mosamala mukamagwira ntchito yoyendetsa magalimoto ndi anthu omwe ntchito yawo imalumikizidwa ndi chidwi chochuluka.