Mapiritsi a Amoxiclav

The zikuchokera mapiritsi 250 mg / 125 mg yogwira pophika amoxicillin (mawonekedwe a trihydrate) ndi clavulanic acid (potaziyamu mchere). Mapiritsiwo amakhalanso ndi zigawo zothandiza: MCC sodium croscarmellose.

Mapiritsi a Amoxiclav 2X 625 mg ndi 1000 mg ili ndi zigawo zomwe zimagwira amoxicillin ndi clavulanic acid, komanso zina zowonjezera: anhydrous colloidal silicon dioxide, zonunkhira, machitidwe, oxide wachikasu chachitsulo, talc, mafuta a castrogen hydrate, MCC silrate.

Yopangidwa ndi mapiritsi Amoxiclav Quicktab 500 mg ndi 875 mg Muli yogwira pophika amoxicillin ndi clavulanic acid, komanso zina zowonjezera: anhydrous colloidal silicon dioxide, flavorings, aspartame, yellow iron oxide, talc, hydrogenated castor mafuta, MCC silicate.

Yopangidwa ndi ufa womwe kuyimitsidwa kwawakonzekere Amoxiclavmulinso amoxicillin ndi clavulanic acid, komanso ngati zinthu zopanda pake zimaphatikizanso sodium citrate, MCC, sodium benzoate, mannitol, sodium saccharin.

Yopangidwa ndi ufa pokonzekera kulowetsedwa Amoxiclav iv muli amoxicillin ndi clavulanic acid.

Kutulutsa Fomu

Mankhwalawa ali ngati mapiritsi. Amoxiclav 250 mg / 125 mg - mapiritsi okhala ndi mbali, phukusili lili ndi ma PC 15.

Amoxiclav 2X (500 mg / 125 mg, 875 mg / 125 mg) - mapiritsi, omwe amaphatikizidwa, amatha kukhala ndi 10 kapena 14 ma PC.

Amoxiclav Quicktab (500 mg / 125 mg, 875 mg / 125 mg) amapezeka mu mawonekedwe a mapiritsi omwazika, phukusi - mapiritsi 10 otere.

Komanso, chinthucho chimapangidwa ngati ufa kuchokera komwe kuyimitsidwa kumapangidwira; botolo limakhala ndi ufa wokonzekera 100 ml ya chinthucho.

Ufa umapangidwanso, momwe umapangidwira yankho, lomwe limayendetsedwa kudzera m'mitsempha. Botolo ili ndi 600 mg ya mankhwalawa (amoxicillin 500 mg, clavulanic acid 100 mg), mabotolo a 1.2 g amapezekanso (amoxicillin 1000 mg, clavulanic acid 200 mg), 5 fl.

Zotsatira za pharmacological

Kuzindikira kumapereka chidziwitso kuti mankhwala Amoxiclav (INN Amoksiklav) ndiwothandiza pazowonera zambiri. Gulu la antibiotic: penicillin yotakata. Kuphatikizidwa kwa mankhwalawa kuli amoxicillin (penicillin semi-synthetic) ndi clavulanic acid (β-lactamase inhibitor). Kupezeka kwa clavulanic acid pakukonzekera kumatsimikizira kukana kwa amoxicillin machitidwe a β-lactamases, omwe amapangidwa ndi tizilombo.

Kapangidwe ka clavulanic acid ndi ofanana ndi mankhwala a beta-lactam, mankhwalawa amakhalanso ndi antibacterial. Amoxiclav ikugwira ntchito yolimbana ndi zovuta zomwe zimawonetsa kukhudzika kwa amoxicillin. Ichi ndi mzere mabakiteriya abwino, aerobic gram-negative bacteria, gram zabwino ndi gram alibe anaerobes.

Pharmacokinetics ndi pharmacodynamics

Malinga ndi kalozera wamankhwala a Vidal, pambuyo pakukonzekera pakamwa, zinthu zonse ziwiri zimaphatikizidwa kuchokera m'matumbo, kuyamwa kwa zinthuzo sikukhudzidwa ndi chakudya, choncho zilibe kanthu kuti muzidya bwanji musanadye kapena mutatha kudya. Oyang'anira ndende kwambiri magazi anati ola limodzi atamwa mankhwalawo. Zosakaniza zonse ziwiri za mankhwalawa zimagawidwa m'madzi ndi zimakhala. Amoxicillin amalowanso m'chiwindi, madzi amtunduwu, Prostate, ma cell, chikhodzodzo, minofu yamatenda, malovu, kubisala kwa bronchial.

Ngati ziwalo zaubongo sizipsa, zonse zomwe zimagwira sizimalowa mu BBB. Nthawi yomweyo, zigawo zikuluzikulu zimadutsa zotchinga, zovuta zawo zimatsimikiziridwa mkaka wa m'mawere. Amamangirira mapuloteni am magazi pang'ono.

Mthupi, amoxicillin amakhala ndi tsankho kagayidwe, clavulanic acid imapangidwa mwamphamvu kwambiri. Amachotsedwa m'thupi kudzera mu impso, tinthu tating'onoting'ono tomwe timatulutsa timatulutsa timimba ndi mapapu. Hafu ya moyo wa amoxicillin ndi clavulanic acid ndi maola 1-1,5.

Zowonetsa kugwiritsa ntchito Amoxiclav

Amoxiclav amalembera matenda opatsirana komanso otupa omwe amayamba chifukwa cha mphamvu ya tizilombo tomwe timayamwa mankhwalawa. Zizindikiro zotsatirazi zogwiritsira ntchito mankhwalawa zimatsimikiziridwa:

• matenda a ziwalo za ENT, komanso matenda opatsirana a chapamwamba kupuma thirakiti (otitis mediapharyngeal chotupa, sinusitis, pharyngitismatendawa)
• matenda amkodzo thirakiti ( cystitisat Prostate etc.)
• matenda a m'munsi kupuma thirakiti (chibayo, bronchitispachimake komanso chovuta)
• matenda azachidziwitso a matenda opatsirana,
• matenda a cholumikizira mafupa,
• matenda opatsirana a minofu yofewa, khungu (kuphatikizapo zotsatira zakuluma),
• matenda a m'mimba thirakiti (cholangitis, cholecystitis),
• matenda odontogenic.

Zomwe zimathandizanso Amoxiclav, muyenera kufunsa katswiri kuti mukambirane.

Contraindication

Kudziwa chifukwa chake mapiritsi ndi mitundu ina ya mankhwalawa amathandizira, munthu akuyenera kukumbukiranso zotsutsana zomwe zilipo kale:

• matenda mononucleosis,
• matenda am'mimba oyambitsidwa ndi chiwindi kapena cholestatic jaundice mukamamwa clavulanic acid kapena amoxicillin,
• lymphocytic leukemia,
• chidwi chachikulu ndi mankhwala opha maantibayotiki kuchokera pagulu la cephalosporins, penicillin, komanso mankhwala ena a beta-lactam,
• kukhudzika kwakukulu pazigawo zogwira ntchito za mankhwala.

Amalembedwa mosamala kwa anthu omwe ali ndi vuto la kuchepa kwa chiwindi, anthu omwe ali ndi matenda oopsa a impso.

Zotsatira zoyipa

Mukamamwa maantibayotiki, zotsatira zotsatirazi zitha kuoneka mwa odwala:

• Matumbo oyenda: kuwonongeka kulakalakakusanza, nseru, kutsegula m'mimba, kawirikawiri, kuwonetsa kupweteka kwam'mimba, kukanika kwa chiwindi ndikotheka, chiwonetsero chimodzi ndi hepatitis, jaundice, pseudomembranous colitis.
• Hematopoietic dongosolo: Nthawi zina, reukopenia, thrombocytopenia, kawirikawiri - eosinophilia, pancytopenia.
• Mawonetseredwe amatsutsa: kuyabwazotupa za erythematous urticaria, nthawi zina - anaphylactic manthakukokoloka kwachisoni, kutupa, Matupi a vasculitis, mawonetseredwe amodzi - Stevens-Johnson syndrome, pustulosis, exfoliative dermatitis.
• Machitidwe amachitidwe amanjenje: chizungulire, mutu, nthawi zina - kukomoka, kumva kuda nkhawa, kusowa tulo.
• Njira yamikodzo: khalid, interstitial nephritis.
• Nthawi zina, kukhala wamphamvu kwambiri kumachitika.

Amadziwika kuti chithandizo chotere, monga lamulo, sichimabweretsa mavuto.

Malangizo ogwiritsira ntchito Amoxiclav (Njira ndi Mlingo wa Amoxiclav kwa akuluakulu)

Mankhwala omwe amapezeka m'mapiritsi sakhazikitsidwa kwa ana osakwana zaka 12. Popereka mankhwala, muyenera kukumbukira kuti mlingo wovomerezeka patsiku la clavulanic acid ndi 600 mg (kwa akuluakulu) ndi 10 mg pa 1 kg ya kulemera kwa mwana. Mlingo wovomerezeka watsiku ndi tsiku wa amoxicillin ndi 6 ga kwa munthu wamkulu ndi 45 mg pa 1 kg yoleza mwana.

Kukonzekera kwa makolo kumakonzedwa ndikumatha kusungunula kwa vial m'madzi jekeseni. Kutha kwa 600 mg ya mankhwalawa, muyenera magawo 10 a madzi, kupasuka kwa 1.2 g ya mankhwalawa - 20 ml ya madzi. Njira yothetsera vutoli iyenera kuperekedwa pang'onopang'ono kwa mphindi 3-4. Kulowetsedwa kwamitseko kumayenera kupitilira kwa mphindi 30 mpaka 40. Osamayimitsa yankho.

Pamaso pa opaleshoni yoletsa kuphatikizira kwa purulent mavuto, muyenera kulowetsedwa kudzera mu mtsempha wa 1.2 g wa mankhwala. Ngati pali vuto la zovuta, mankhwalawa amaperekedwa kudzera pakhungu kapena pakamwa panthawi yomwe akuchitidwa opareshoni. Kutalika kwa kuvomerezedwa ndi adokotala.

Mapiritsi a Amoxiclav, malangizo ogwiritsira ntchito

Monga lamulo, achikulire ndi ana (omwe kulemera kwawo ndi woposa 40 makilogalamu) amalandira piritsi 1 lililonse maola asanu ndi atatu. (375 mg), bola ngati matendawa ndi ofatsa kapena ochepa. Njira inanso yovomerezeka pamilandu iyi ndi piritsi 1 lililonse maola 12. (500 mg + 125 mg). Kwa matenda opatsirana opatsirana, komanso matenda opatsirana am'mapapo, piritsi limodzi limawonetsedwa maola asanu ndi atatu aliwonse. (500 mg + 125 mg) kapena kudya piritsi lililonse la maola 12. (875 mg + 125 mg). Kutengera ndi matendawa, muyenera kumwa maantibayotiki masiku khumi ndi anayi, koma adotolo ayenera payekha kupereka mankhwala.

Kwa odwala omwe ali ndi matenda odontogenic, onetsani mankhwala maola 8 aliwonse, piritsi limodzi. (250 mg + 125 mg) kapena kamodzi kwa maola 12, piritsi limodzi lililonse. (500 mg + 125 mg) kwa masiku asanu.

Anthu okhala ndi malire kulephera kwa aimpsoPhwando la tebulo limodzi likuwonetsedwa. (500 mg + 125 mg) maola 12 aliwonse. Kulephera mwamphamvu kwaimpso ndi chifukwa chokulitsa nthawi yomwe yapezeka pakati Mlingo mpaka maola 24.

Kuyimitsidwa Amoxiclav, malangizo ntchito

M'badwo wa ana wodwalayo umapatsa kuwerengera kwa mlingo poganizira kulemera kwa mwana. Musanakonze madziwo, muyenera kugwedeza botolo bwino. Mlingo iwiri, 86 ml ya madzi uyenera kuwonjezeredwa m'botolo, nthawi iliyonse mukafuna kugwedeza zomwe zili mkati mwake bwino. Tiyenera kudziwa kuti supuni yoyesera imakhala ndi 5 ml ya malonda. Perekani mlingo kutengera zaka komanso kulemera kwa mwana.

Malangizo ogwiritsira ntchito Amoxiclav kwa ana

Kuyambira pobadwa mpaka miyezi itatu, ana amapatsidwa mankhwala pamlingo wa 30 mg pa 1 makilogalamu (patsiku), mankhwalawa amayenera kugawidwa mofananamo ndikuwathandizira nthawi zonse. Kuyambira wazaka zitatu, Amoxiclav amamuika pa 25 mg wa kulemera kwake pa kilogalamu imodzi, amafanizidwa chimodzimodzi. Pankhani ya matenda opatsirana olimba, kuchuluka kwake kumayikidwa pa 20 mg pa 1 makilogalamu kulemera kwake, amagawika pazigawo zitatu. Mu matenda opatsirana opatsirana, mlingo umayikidwa pa mlingo wa 45 mg pa 1 makilogalamu kulemera, ugawikane awiri Mlingo patsiku.

Malangizo ogwiritsira ntchito Amoxiclav Quicktab

Asanatenge, piritsi liyenera kusungunuka mu 100 ml ya madzi (kuchuluka kwa madzi kungakhale kambiri). Sanjani zomwe zili mkati musanagwiritse ntchito. Mukhozanso kutafuna piritsi, ndibwino kugwiritsa ntchito mankhwalawa musanadye. Akuluakulu ndi ana atafika zaka 12 ayenera kumwa piritsi limodzi patsiku. 625 mg katatu patsiku. M'matenda opatsirana opweteka, piritsi 1 ndi mankhwala. 1000 mg 2 kawiri pa tsiku. Kuchiza sikuyenera kupitilira milungu iwiri.

Nthawi zina adotolo atha kufotokozera fanizo la mankhwalawa, mwachitsanzo, Flemoklav Solutab ndi ena.

Amoxiclav ndi angina

Mankhwala a Amoxiclav zilonda zapakhosi wamkulu ndi piritsi 1. 325 mg kamodzi pa maola 8 aliwonse. Njira inanso yoyenera imaphatikizira kumwa piritsi limodzi kamodzi pa maola 12 aliwonse. Dokotala atha kukulemberani mankhwala apamwamba ngati matendawo ali akulu. Chithandizo cha angina mu ana zimaphatikizapo kugwiritsa ntchito kuyimitsidwa. Monga lamulo, supuni 1 imayikidwa (supuni ya kumwa ndi 5 ml). Pafupipafupi kuvomerezedwa ndi adokotala, zomwe ndizofunika kutsatira. Momwe kumwa Amoxiclav mu ana angina zimatengera kuopsa kwa matendawa.

Mlingo wa Amoxiclav wa sinusitis

Kodi Amoxiclav amathandizira ndi sinusitis, zimatengera zomwe zimayambitsa matendawa. Mlingo watsimikiza ndi otolaryngologist. Ndikulimbikitsidwa kuti mumwe mapiritsi 500 mg katatu patsiku. Masiku angati kumwa mankhwalawa zimatengera kuopsa kwa matendawa. Koma zizindikiro zikatha, muyenera kumwa mankhwalawo masiku ena awiri.

Bongo

Popewa kumwa mopitirira muyeso, mulingo woyenera wa ana ndi kuchuluka kwa Amoxiclav kwa achikulire uyenera kuonedwa bwino. Ndikulimbikitsidwa kuti muphunzire malangizo mosamala kapena muwone kanema wamomwe mungathandizire kuyimitsidwa.

Wikipedia ikuwonetsa kuti ndi kuchuluka kwa mankhwalawa, zizindikiro zingapo zosasangalatsa zingachitike, koma palibe deta pazomwe zimawopseza wodwalayo. Mankhwala osokoneza bongo amatha kuchitika. kupweteka kwam'mimba, kusanza, kutsegula m'mimbachisangalalo. Nthawi zina zimakhala zovuta.

Ngati mankhwalawa adatengedwa posachedwapa, chapamimba chimachitika, chikuwonetsedwa kaboni yodziyambitsa. Wodwala ayenera kuyang'aniridwa ndi dokotala. Kugwiritsa ntchito pamenepo hemodialysis.

Kuchita

Ndi munthawi yomweyo kugwiritsa ntchito mankhwala enaake ndi mankhwala ena, mawonekedwe osafunikira amatha kuchitika, chifukwa chake mapiritsi, madzi ndi mapangidwe ake amitsempha sayenera kugwiritsidwa ntchito limodzi ndi mankhwala angapo.

Ntchito munthawi yomweyo Glucosamine, maantacid, aminoglycosides, mankhwala ofewetsa nkhawa amachepetsa kuyamwa kwa Amoxiclav, mukamamwa pamodzi Ascorbic acid - mayamwidwe kwachitika mofulumira.

Ndi mankhwala omwewa pamodzi ndi phenylbutazone, okodzetsa, NSAIDs, Allopurinol ndi mankhwala ena omwe amatseka katulutsidwe ka tubular, kuwonjezeka kwa kuchuluka kwa amoxicillin kumachitika.

Ngati munthawi yomweyo makonzedwe a anticoagulants ndi Amoxiclav amachitidwa, nthawi ya prothrombin imawonjezeka. Chifukwa chake, ndikofunikira kupereka ndalama mosakanikirana mosamala.

Amoxiclav imawonjezera kawopsedwe Methotrexate mukutenga.

Mukamamwa Amoxiclav ndipo Allopurinol mwayi wowonetsera wa exanthema ukuwonjezeka.

Sayenera kumwedwa nthawi yomweyo Disulfiramndi Amoxiclav.

Otsutsa ogwirizana ndi amoxicillin ndipo Rifampicin. Mankhwala onse amachepetsa mphamvu ya antibacterial.

Amoxiclav ndi bacteriostatic antibacterial (tetracyclines, macrolides), komanso sulfonamides sayenera kumwa nthawi yomweyo, chifukwa mankhwalawa amatha kuchepetsa mphamvu ya Amoxiclav.

Khalid kumawonjezera ndende ya amoxicillin ndikuchepetsa mayeso ake.

Mukamagwiritsa ntchito Amoxiclav, mphamvu ya zotsatirapo za kulera kwapakamwa imatha kuchepa.

Malangizo apadera

Popeza anthu ambiri omwe ali ndi lymphocytic leukemia komanso opatsirana mononucleosis ndi omwe adalandira Ampicillin, Pambuyo pake adawonetsa kuwonekera kwa zotupa za erythematous, anthu oterewa saloledwa kumwa maantibayotiki a gulu la ampicillin.

Chenjezo lomwe limaperekedwa kwa anthu okhala ndi cholembera chifuwa.

Ngati njira yochizira ndi mankhwalawa imaperekedwa kwa akulu kapena ana, ndikofunikira kuyang'anira impso, chiwindi, ndi kapangidwe ka magazi.

Anthu omwe ali ndi vuto la impso amafunikira kusintha kwa mlingo kapena kukulira kwakanthawi pakati pa mankhwala.

Mulingo woyenera kumwa mankhwalawo nthawi ya chakudya kuti muchepetse zovuta zoyambira m'mimba.

Odwala omwe akuchipatala ndi Amoxiclav, zotsatira zabodza zitha kuwoneka pakupanga shuga mumkodzo pogwiritsa ntchito yankho la Felling kapena Benedict's reagent.

Palibe chidziwitso pazovuta za Amoxiclav pakutha kuyendetsa magalimoto ndikugwira ntchito moyenera.

Odwala omwe ali ndi chidwi ndi Amoxiclav ndi antiotic kapena ayi, ziyenera kukumbukiridwa kuti mankhwalawa ndi antibacterial.

Ndikulimbikitsidwa kumwa madzi ambiri ndi madzi ena munthawi ya mankhwalawa.

Ngati Amoxiclav ndi mankhwala, zaka za wodwalayo ziyenera kuganiziridwa popereka mankhwala ndi mlingo.

Analogi za Amoxiclav

Pali zitsanzo zingapo za mankhwalawa. Mtengo wa analogi zimatengera, choyambirira, pa wopanga mankhwalawo. Pali ma analogu ogulitsa otsika mtengo kuposa Amoxiclav. Kwa odwala omwe ali ndi chidwi chofuna kuthana ndi maantibayotiki, akatswiri amapereka mndandanda waukulu wa mankhwalawa. Izi zikutanthauza Moxiclav, Co-Amoxiclav, Augmentin, Clavocin, Flemoklav, Samalirani, Baktoklav, Ranklav, Amovicombndi ena Komabe, ndi dokotala yekha yemwe ayenera kupereka mankhwala othandizira. Mutha kusankha analogue yotsika mtengo pamapiritsi, mwachitsanzo, Augmentin. Muthanso kusankha analogue yaku Russia, mwachitsanzo, Amoxicillin.

Zomwe zili bwino: Amoxiclav kapena Augmentin?

Kodi Amoxiclav ndi Augmentin akupanga chiyani, pali kusiyana kotani pakati pa mankhwalawa? Zida zonsezi zili ndi zosakaniza zofanana, ndiye kuti, izi ndizofanana. Momwemo, zamankhwala zimapangitsa mankhwalawo kukhala ofanana, komanso mavuto ena. Opanga okha mankhwalawa ndiomwe amasiyana.

Amoxiclav pa mimba ndi mkaka wa m`mawere

Amoxiclav mimba itha kugwiritsidwa ntchito ngati zomwe zikuyembekezeredwa zikuchuluka kuposa zomwe zingavulaze mwana wosabadwayo. Kugwiritsa ntchito Amoxiclav koyambirira kwa mimba ndikosayenera. 2 trimester ndi 3 trimester ndizofunikira kwambiri, koma ngakhale panthawiyi, mlingo wa Amoxiclav pa nthawi yoyembekezera uyenera kuchitika mosamala kwambiri. Amoxiclav yoyamwitsa osapereka mankhwala, popeza magawo a mankhwala amalowerera mkaka wa m'mawere.

Ndemanga za Amoxiclav

Mukukambirana za Amoxiclav ya mankhwalawa, ndemanga za madokotala ndi odwala ndizabwino. Amadziwika kuti maantibayotiki amatha kuthandizira matenda opuma, ndipo ndioyenera kwa onse akuluakulu ndi ana. Ndemanga zimatchulapo mphamvu ya mankhwalawa a sinusitis, pa otitis media, matenda a kumaliseche. Monga lamulo, odwala achikulire amatenga mapiritsi a 875 mg + 125 mg, ndi mlingo woyenera, mpumulo wamatendawo umabwera msanga. M'mawunikidwe, zimadziwika kuti njira yothana ndi maantibayotiki, ndikofunika kumwa mankhwala omwe amayambiranso microflora.

Ndemanga za kuyimitsidwa kwa Amoxiclav ndizabwino. Makolo amalemba kuti ndibwino kupatsa ana zinthuzo chifukwa zimakoma kwambiri ndipo ana amazizindikira.

Mtengo wa Amoxiclav, komwe ungagule

Mtengo Mapiritsi a Amoxiclav 250 mg + 125 mg pafupifupi 200 ma ruble a 15 ma PC. Gulani maantibayotiki 500 mg + 125 mg ikhoza kukhala yamtengo wapatali pa 360 - 400 rubles kwa ma 15 pcs. Kodi mapiritsi ndi angati? 875 mg + 125 mgzimatengera malo ogulitsa. Pafupifupi, mtengo wawo ndi 420 - 470 rubles kwa 14 ma PC.

Mtengo Amoxiclav Quicktab 625 mg - kuchokera ku ma ruble 420 a ma PC 14.

Mtengo wa kuyimitsidwa Amoxiclav ya ana - 290 ma ruble (100 ml).

Mtengo Amoxiclav 1000 mg ku Ukraine (Kiev, Kharkov, etc.) - kuchokera ku 200 h scrollnias 14 zidutswa.

Mlingo ndi makonzedwe

Mapiritsi a Amoxiclav amawerengedwa kwa odwala azaka zopitilira 12 ndi masekeli oposa 40 kg.

Matenda ofatsa kwambiri mankhwala ndi mankhwala:

• 250 mg + 125 mg (375 mg) katatu patsiku,
• 500 mg + 125 mg (625 mg) kawiri pa tsiku.

Woopsa matenda, komanso matenda amtundu wa kupuma, Amoxiclav pamapiritsi amatchulidwa muyezo:

• 500 mg + 125 mg (625 mg) katatu patsiku,
• 875 mg + 125 mg (1000 mg) kawiri pa tsiku.

Mlingo wapamwamba kwambiri wa tsiku ndi tsiku wa amoxicillin wa akulu ndi 6 g, clavulanic acid 600 mg.

Mlingo wapamwamba kwambiri wa ana a tsiku lililonse wa amoxillin ndi 45 mg pa kilogalamu ya kulemera, clavulanic acid 10 mg pa kg.

Kutalika kwa chithandizo kungakhale kuyambira masiku 5 mpaka 14. Nthawi yochuluka ya kumwa mankhwalawa iyenera kuganiziridwa ndi dokotala.

Matenda amkamwa, Amoxiclav mu mlingo wa 375 mg wa mankhwala 3 mg tsiku, pa mlingo wa 625 mg - 2 kawiri pa tsiku kwa masiku 5.

Ngati wodwala ali ndi matenda a impso omwe amakhala ndi kusefukira kwa mphindi 10 mpaka 30 pamphindi, ndiye kuti mankhwalawa amalembedwa muyezo wa 625 mg ndi nthawi yotalikirapo maola 12, ngati kuvomerezedwa kwa creatine kumakhala kosakwana 10 ml kwa mphindi, ndiye kuti pafupipafupi makonzedwe amachepera 1 nthawi patsiku.

Popanda kukodza mkodzo, nthawi yotalikirana pakumwa piritsi lotsatira iyenera kukhala masiku osachepera awiri.

Zotsatira zoyipa

Mukamamwa mankhwalawa, zotsatirazi zosafunikira zitha kuonekera, zomwe zimafotokozedwa pang'ono ndikumatha kutha kwa chithandizo:

• kusowa kwa chakudya, kutsekula m'mimba, kusanza, kusanza, chiwindi.
• chifuwa
• kuchuluka kwa eosinophils, nthawi yayitali prothrombin, kutsitsa magazi onse,
• kuchita kwambiri, nkhawa, kugona tulo, kukokana, chizungulire, kupweteka mutu,
• saline diathesis, interstitial nephritis,
• kupatsika chidwi, kuphatikiza kupindika.

Monga yogwira zinthu, amoxicillin ndi clavulanic acid ali m'gulu la mapiritsi:

Monga zowonjezera zina, mapangidwe ake a mapiritsi ndi:

• kufinya silika,
• MCC
• talcum ufa
• magnesium wakuba,
• polyvinylpyrrolidone,
• croscarmellose sodium.

Zomwe zimapangidwa ndi nembanemba wa filimu ndizophatikizira:

• talcum ufa:
• mapasa 80,
• hypopellose,
• Izi ndi cholinga
• titanium oxide
• triethyl citrate.

Pharmacology ndi pharmacokinetics

Amoxiclav amadziwika ndi mawonekedwe osiyanasiyana a antimicrobial zochita. Ma tizilombo totsatirawa tazindikira maantiotic:

• streptococci,
• Yersinia enterocolitis,
• khalimotz,
• gardnerella vaginalis,
• E. coli
• Klebsiella
• gonococci
• meningococci,
• Shigella
• nsomba
• cholera vibrio,
• Proteus
• ma bacteria
• wand
• pasteurella kupha,
• fusobacteria,
• brucella
• campylobacter ayuni,
• Ducrey wand,
• fuluwenza wand
• Helicobacter pylori,
• moraxella cataralis,
• peptococci,
• peptostreptococcus,
• clostridia
• preotella.

Pambuyo pakukonzekera pakamwa, zinthu zonse ziwiri zomwe zimagwira ntchito zimapangidwa mwachangu kuchokera kugaya chakudya, kuphatikiza kwakukulu kumawonedwa pambuyo pa ola limodzi. Kudya sizikhudzana ndi mayamwa.

Maantibayotiki amalowa m'matumbo ndi ziwalo zambiri, ndikudutsa placenta ndipo amamuchotsera pang'ono mkaka wamawere.

Amapukusidwa mu chiwindi, chotsekedwa makamaka ndi impso, theka la moyo limasiyana kwa maola 1 mpaka 1.5.

Mukuyenda kwambiri kwa aimpso, theka la moyo wa amoxicillin limawonjezeka mpaka maola 7.5, chifukwa cha clavulanic acid mpaka maola 4.5.

Migwirizano ndi magwiritsidwe akusungidwa

Mankhwalawa atha kugulidwa ndi mankhwala a dokotala. Mapiritsi amayenera kusungidwa m'malo owuma pomwe ana sangathe kuwapeza, pa t 25 25 yayitali.

(Siyani ndemanga yanu mu ndemanga)

* - Mtengo wapakati pakati pa ogulitsa angapo panthawi yowunikira siwoperekedwa pagulu

Mapiritsi a Amoxiclav ndi ufa - malangizo ogwiritsira ntchito

Kwa ana ochepera zaka 12 - 40 mg pa kilogalamu ya kulemera kwa tsiku.
Kwa ana omwe kulemera kwawo kupitilira 40 makilogalamu, mankhwalawa amamulembera ngati munthu wamkulu.

Akuluakulu amalembedwa: Mapiritsi 375 mg amatengedwa tsiku lililonse la 8 tsiku lililonse, mapiritsi a 625 mg maola 12 aliwonse. Popereka mankhwala othandizira odwala kwambiri, Mlingo wa 625 mg maola 8 aliwonse, kapena 1000 mg maola 12 aliwonse, amagwiritsidwa ntchito.

Tiyenera kudziwa kuti mapiritsi amatha kusiyanasiyana malinga ndi zomwe zimagwira. Chifukwa chake, simungathe kusintha piritsi la 625 mg (500 g ya amoxicillin ndi 125 g ya clavulanic acid) ndi mapiritsi awiri 375 mg (250 g of amoxicillin ndi 125 g ya clavulanic acid).

Dongosolo lotsatirali limagwiritsidwa ntchito pochiza matenda a odontogenic. Mapiritsi 375 mg amatengedwa maola 8 aliwonse, pozungulira wotchi. Mapiritsi a 625 mg pambuyo pa maola 12.

Ngati kuli kofunikira kugwiritsa ntchito mankhwalawa kuchiza odwala omwe ali ndi matenda a impso, mkodzo wa creatinine uyenera kukumbukiridwa. Odwala omwe ali ndi matenda a chiwindi amafunikira kuwunika ntchito yawo nthawi zonse.

Mphamvu yakuyimitsidwa kwa makanda ndi ana mpaka miyezi itatu. Dosing imachitika pogwiritsa ntchito kapeniki woyezera wapadera kapena supuni. Mlingo - 30 mg ya amoxicillin pa kilogalamu ya kulemera, kawiri pa tsiku.

Kwa ana okulirapo kuposa miyezi itatu kwa matenda ofatsa komanso odziletsa - 20 mg / kg yolemetsa thupi, komanso matenda oopsa - 40 mg / kg. Mlingo wachiwiri umagwiritsidwanso ntchito pochizira matenda oopsa - kutupa kwa khutu lapakati, sinusitis, bronchitis, chibayo. Malangizo amaphatikizidwa ndi mankhwalawa, momwe mumakhala matebulo apadera omwe amakupatsirani kuti muwerenge molondola kuchuluka kwa mankhwalawa kwa ana.

Mlingo wovomerezeka wa ana tsiku lililonse ndi ana ndi 45 mg / kg, kwa akulu - 6 magalamu. Clavulanic acid imatha kutengedwa patsiku osaposa 600 mg kwa akulu ndi 10 mg / kg kwa ana.

Kufotokozera kwa mafomu omasulira

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi okhala ndi zoyera kapena zoyera. Mapiritsiwo ali ndi mawonekedwe owundana a biconvex.

Piritsi limodzi la 625 mg limakhala ndi 500 mg ya amoxicillin trihydrate ndi 125 mg ya clavulanic acid (mchere wa potaziyamu).

Mapiritsi amatha kupanga zitini zamapulasitiki (mapiritsi 15 aliyense) kapena matuza a aluminium a 5 kapena 7.

Mapiritsi a 1000 mg amaphatikizanso, amakhala ndi mawonekedwe osungika okhala ndi mbali zopindika. Pa iwo, mbali imodzi, zolemba za "AMS" zimayikidwa, mbali inayo - "875/125". Amaphatikizapo 875 mg ya antiotic ndi 125 mg ya clavulanic acid.

Kugwirizana kwina ndi mankhwala ena

• Ndiosafunika kugwiritsa ntchito nthawi yomweyo Amoxiclav ndi kukonzekera kwa anticoagulants. Izi zingayambitse kuchuluka kwa prothrombin nthawi.
• Kugwirizana kwa Amoxiclav ndi allopurinol kumayambitsa chiopsezo cha exanthema.
• Amoxiclav imawonjezera kawopsedwe wa metatrexate.
• Simungagwiritse ntchito onse amoxicillin ndi rifampicin - awa ndi osokoneza, ophatikizira ntchito amachepetsa mphamvu ya antibacterial onse.
• Amoxiclav sayenera kulembedwa pamodzi ndi tetracyclines kapena macrolides (awa ndi mankhwala opatsirana a bacteriostatic), komanso sulfonamides chifukwa kuchepa kwa mphamvu ya mankhwalawa.
• Kutenga Amoxiclav kumachepetsa mphamvu zakulera m'mapiritsi.

Madokotala amafufuza

Anna Leonidovna, wothandizira, Vitebsk. Amoxiclav imakhala yothandiza kwambiri pochiza matenda osiyanasiyana opuma kuposa momwe analogue, amoxicillin. Ndikupereka maphunzirowa masiku 5, kenako ndikofunikira kumwa mankhwala omwe amakonzanso microflora.

Veronika Pavlovna, dotolo. Mr. Kreshyi Rih. Mankhwalawa ali ndi zabwino kwambiri pakubwera kwamtundu wa bakiteriya. Sichimaperekanso zovuta, nthawi yomweyo ndimapereka mankhwala a antifungal, nditatha kumwa ma probiotic kuti ndikonzenso microflora yachilendo.

Andrei Evgenievich, dotolo wa ENT, Polotsk. Kugwiritsa ntchito mankhwalawa jekeseni kumakuthandizani kuti muchepetse kuwonetsa kwa matenda oopsa komanso olimbitsa a ziwalo za ENT. Mankhwala amathandizira kutukusira khutu lapakati. Kuphatikiza apo, odwala amatenga bwino kuyimitsidwa kwa zipatso.

Kufotokozera za mankhwalawa

Amoxiclav imakhala ndi zigawo zikuluzikulu ziwiri. Choyamba, ichi ndi semisynthetic penicillin - amoxicillin, komanso clavulanic acid. Gawo lililonse limakhala ndi ntchito yake. Amoxicillin ndi mmodzi mwa mankhwala, komabe, clavulanic acid ilibe mphamvu yodziwika bwino ya antibacterial. Kodi cholinga chake ndi chiyani?

Monga mukudziwira, ma penicillin ndi amodzi mwa mankhwala oyamba omwe analandilidwa mkati mwa zaka zapitazi. Pogwiritsa ntchito, awonetsa luso lawo lokwera. Koma nthawi yomweyo, mabakiteriya ambiri adatha kuyambitsa kukana. Kodi chitetezo cha bakiteriya ku mankhwala othandizira chimagwira ntchito bwanji?

Amoxicillin amagwira ntchito pa cell membrane wa bakiteriya, womangiriza imodzi ya michere yomwe imapangika. Zotsatira zake, khoma la maselo limataya mphamvu, limawonongedwa ndipo bacterium imamwalira. Komabe, mitundu yambiri ya mabakiteriya idayamba kupanga zinthu zapadera - beta-lactamases, zomwe zimalepheretsa maantibayotiki. Chifukwa chake, amoxicillin sanakhale wopanda vuto kwa mabakiteriya ambiri.

Clavulanic acid adapangidwa kuti athane ndi beta-lactamases. Mwa kumanga kwa amoxicillin, zimapangitsa ma molekyulu opha maantibayotiki kukhala a beta-lactamases. Izi zimawonetsedwa pokhudzana ndi mitundu yambiri ya beta-lactamases yopangidwa ndi mabakiteriya.

Chifukwa chake, kuphatikiza kwa amoxicillin ndi clavulanic acid kumakhala ndi zochitika zambiri za antibacterial kuposa amoxicillin wangwiro. Ngati amoxicillin angakhudze ochepa mabakiteriya omwe sangathe kupanga beta-lactamases, ndiye amoxicillin, wophatikizidwa ndi clavulanic acid, amagwira ntchito motsutsana ndi mabakiteriya ambiri omwe amayambitsa matenda opatsirana. Mwa mabakiteriya omwe Amoxiclav amatha kuwononga, palinso mabakiteriya omwe ali ndi gramu komanso gram-negative.

Mitundu yayikulu ya mabakiteriya omwe amamva Amoxiclav:

• streptococci,
• khalimotz,
• Shigella
• Klebsiella
• brucella
• echinococcus,
• Helicobacter
• clostridia
• hemophilic bacillus,
• nsomba
• Proteus.

Mabakiteriya olimbana ndi Amoxiclav:

• enterobacter
• pseudomonads
• chlamydia
• mycoplasmas
• legionella
• Yersinia

ndi ena.

Mankhwala

Amoxicillin ndi penicillin wopanga yemwe amagwiritsa ntchito zinthu zambiri zamagalamu zopanda pake komanso gram zabwino. Imalepheretsa biosynthesis ya peptidoglycan, yomwe ndi gawo la kapangidwe ka khoma la bakiteriya. Kutsika kwa kupanga kwa peptidoglycan kumayambitsa kuchepa kwa mphamvu ya maselo a maselo, omwe pambuyo pake amatsogolera pakuwunika ndi kufa kwa maselo a tizilombo tating'onoting'ono. Nthawi yomweyo, amoxicillin amakhudzika ndi zochitika za beta-lactamases, omwe amaziwononga, chifukwa chake mawonekedwe ake a antibacterial sakuphatikiza ma tizilombo opanga enzyme iyi.

Clavulanic acid ndi beta-lactamase inhibitor, kapangidwe kake kamene kamafanana ndi penicillin. Imatha kuyambitsa ma beta-lactamases ambiri, omwe amapanga tizilombo tokhala ndi kutsimikizika kwa cephalosporins ndi penicillin. Kuchita bwino kwa clavulanic acid mokhudzana ndi plasmid beta-lactamases, yomwe nthawi zambiri imazindikira kukana kwa mabakiteriya maantibayotiki, kwatsimikiziridwa. Komabe, mankhwalawa sakutengera mtundu wa chromosome beta-lactamases omwe sanalepheretsedwe ndi clavulanic acid.

Kupezeka kwa clavulanic acid ku Amoxiclav kumathandizira kupewa kuwonongedwa kwa amoxicillin ndi michere yapadera - beta-lactamases - ndikukulitsa kuchuluka kwa antibacterial ntchito ya amoxicillin.

Kafukufuku wachipatala ku vitro amatsimikizira kukhudzidwa kwakukulu ndi zochita za Amoxiclav pazinthu zotsatirazi:

• gram-negative anaerobes: mitundu ya genus Prevotella, Bacteroides fragilis, mitundu ina ya genus Bacteroides, mitundu ya genus Porphyromonas, mitundu ya genus Capnocytophaga, mitundu ya genus Fusobacterium, Fusobacterium nucleatum, Eikenella corrodens,
• zamaerobes agamu: mitundu ya genus Peptostreptococcus, Peptostreptococcus micus, Peptostreptococcus micros, Peptococcus niger, mitundu ya mtundu wa Clostridium,
• gram-negative aerobes: Vibrio cholerae, Bordetella pertussis, Pasteurella multocida, Haemophilus fuluwenza, Neisseria gonorrhoeae, Moraxella catarrhalis, Helicobacter pylori,
• gram-positive aerobes: coagulase-negative staphylococci (kuwonetsa kukhudzika kwa methicillin), Staphylococcus saprophyticus (tizilombo tating'ono ta methicillin), Staphylococcus aureus (tizilombo tating'ono ndi methicillin), Bacillus anthracis, Streptococococococococococococococococococococococococococococococococococococococcococococcococcococococcococcococ na cac , Nocardia asteroids, Listeria monocytogene,
• Ena: Treponema pallidum, Leptospira icterohaemorrhagiae, Borrelia burgdorferi.

Ma tizilombo totsatirawa amadziwika ndi kukana komwe kumagwira zigawo za Amoxiclav:

• gram-aerobes gram: streptococci of the Viridans group, Streptococcus pneumoniae, Enterococcus faecium, mabakiteriya a genus Corynebacterium,
• Ma grram-negative aerobes: mabakiteriya amtundu wa Shigella, Escherichia coli, mabakiteriya amtundu wa Salmonella, mabakiteriya amtundu wa Klebsiella, Klebsiella pneumoniae (maphunziro azachipatala amatsimikizira kuyendetsa bwino kwa zinthu za Amoxiclav mogwirizana ndi izi, zovuta zake sizikupanga beta-lactamases, cholesteria ya lcybassi wa cell. , Proteus vulgaris, Proteus mirabilis.

Zamoyo zotsatirazi zikuwonetsa kukana kwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

• gram-hasi aerobes: mabakiteriya a mtundu wa Acinetobacter, Yersinia enterocolitica, Citrobacter freundii, Stenotrophomonas maltophilia, mabakiteriya a Enterobacter, Pseudomonas bacteria, Hafnia alvei, bacteria wa geniella a legionella pneumophila, bacteria wa Providencia morganella morganella
• ena: mabakiteriya amtundu wa Mycoplasma, Chlamydophila psittaci, Chlamydophila pneumoniae, mabakiteriya amtundu wa Chlamydia, Coxiella burnetii.

Kuzindikira kwa mabakiteriya ku monotherapy yokhala ndi amoxicillin nthawi zambiri kumatanthauza kuzindikira kofananako ndikuphatikizidwa kwa amoxicillin ndi clavulanic acid.

Ndemanga za Odwala

Victoria, Dnipropetrovsk. Kugwiritsidwa ntchito ndi adokotala pochiza matenda a tonsillitis. Anaona masiku 5. Mankhwala olimbana ndi mankhwalawa adayamba patsiku la 3 la matenda. Matendawa adachepetsa ndi wachitatu. Khosi langa linasiya kuwawa. Panali matenda otsegula m'mimba, ndinadutsa patangotha ​​masiku awiri, nditayamba kumwa mankhwala okonzanso kuti ndikonzenso microflora.

Alexandra, Lugansk. Mankhwalawa adalembedwa ndi dokotala kuti azichiza pyelonephritis. Maphunzirowa anali masiku 7. Jekeseni wa masiku atatu - kenaka mapiritsi. Jakisoni amakhala wowawa. Komabe, kusintha kunayamba mozungulira tsiku lachinayi. Panalibe mavuto. Ndiye kamwa youma ija.

Tamara, mzinda wa Boyarka. Adandilowetsa mankhwalawa ngati mankhwalawa. Zimakhala zopweteka kwambiri, mikwingwirima idatsalira pamalo a jakisoni. Komabe, patatha sabata limodzi palibe chomwe chatsalira mu smears kuchokera kwa pathogen.

Zowonjezera

Ngati mankhwalawa amagwiritsidwa ntchito kwanthawi yayitali, ndikofunikira kuyang'anira ntchito ya chiwindi, ziwalo zopanga magazi ndi impso za wodwalayo. Ngati wodwalayo wasokoneza ntchito yaimpso, ndikofunikira kusintha mlingo kapena kuonjezera pakadali pakati Mlingo wa mankhwala. Ndikwabwino kumwa mankhwala ndi chakudya. Pankhani ya superinfection (mawonekedwe a microflora osazindikira maantibayotiki), ndikofunikira kusintha mankhwalawa. Chifukwa chakuchulukana kwa matupi a cephalosporins mwa odwala omwe ali ndi penicillin, sikofunikira kugwiritsa ntchito maantibayotiki nthawi imodzi.

Mukamamwa mankhwalawa, muyenera kumwa madzi ambiri kuti mupewe mapangidwe amkodzo wa amoxicillin.

Mukuyenera kudziwa kuti kupezeka kwa Mlingo wambiri wa maantibayotiki mthupi kumatha kupangitsa kuti shuga azigwirizana ndi mkodzo (ngati malingaliro a Benedict kapena njira ya Fleming agwiritsidwa ntchito kuti adziwe). Zotsatira zodalirika pamenepa zimapereka ntchito ya enzymatic reaction ndi glucosidase.

Popeza zotsatira zoyipa za m'magazi amanjenje ndizotheka kugwiritsa ntchito mankhwalawa, ndikofunikira kuyendetsa bwino magalimoto (magalimoto) kapena kuchita zinthu zomwe zimafunikira chidwi, kuthamanga ndi chidwi.

Amamasulidwa pa mankhwala.

Mapiritsi ndi yankho la kuyimitsidwa kwamlomo

Malangizo a mankhwalawa komanso kutalika kwa mankhwalawa zimatsimikizika molingana ndi kuopsa kwa matendawa, zaka, ntchito ya impso ya wodwalayo komanso kulemera kwa thupi. M'mapiritsi ndi kuyimitsidwa, Amoxiclav amalimbikitsidwa kuti azimwa ndi zakudya, zomwe zimachepetsa chiopsezo cha zotsatira zoyipa kuchokera kugaya chakudya.

Nthawi zambiri njira yochizira imachokera masiku 5 mpaka 14. Kuchira kwotalikirapo kumatheka pokhapokha ngati mwalandira mayeso awiri.

Mlingo wovomerezeka wa mapiritsi a Amoxiclav a ana osaposa zaka 12 ndi 40 mg / kg patsiku, womwe umagawidwa pazigawo zitatu. Ana omwe ali ndi thupi lolemera kuposa makilogalamu 40 amawonetsedwa kukula kwamankhwala. Kwa ana ochepera zaka 6, ndibwino kugwiritsa ntchito kuyimitsidwa kwa Amoxiclav.

Pali njira ziwiri zothandizira Amoxiclav mwa achikulire omwe ali ndi zofatsa pang'ono:

• Maola 8 aliwonse, piritsi limodzi 250 + 125 mg,
• Maola 12 aliwonse, piritsi 1 500 + 125 mg.

Potengera momwe matendawo aliri ndi matenda opatsirana a kupuma, mapiritsi 1 a 500 + 125 mg ayenera kumwa maola 8 aliwonse kapena piritsi limodzi la 875 + 125 mg maola 12 aliwonse.

Ndi odontogenic matenda, makonzedwe a piritsi 1 la Amoxiclav 250 + 125 mg maola 8 aliwonse kapena piritsi limodzi la 500 + 125 mg maola 12 aliwonse limawonetsedwa masiku 5.

Amoxiclav amalembedwa mwa akhanda ndi ana mpaka miyezi itatu ngati mawonekedwe a kuyimitsidwa pamlingo wa 30 mg / kg patsiku (malinga ndi amoxicillin). Mankhwalawa amatengedwa maola 12 aliwonse. Kuti mutsatire mlingo wake, gwiritsani ntchito mulingo wa piritsi womwe waperekedwa ndi phukusi.

Mlingo wa tsiku ndi tsiku wa Amoxiclav wa ana opitilira miyezi 3 ndi:

• Ndiofatsa pang'ono mwamphamvu matendawa - 20 mg / kg patsiku,
• Woopsa matenda ndi matenda a m'munsi kupuma thirakiti, otitis media, sinusitis - mpaka 40 mg / kg (amoxicillin) patsiku.

Tiyenera kudziwa kuti powerengera za kuchuluka kwa mankhwalawa, munthu sayenera kudalira msinkhu wa mwanayo, koma kulemera kwa thupi lake komanso kuopsa kwa matendawa.

Yankho la jakisoni

Amoxiclav mu mawonekedwe a yankho la jakisoni amaperekedwa kokha.

Kwa ana ochepera miyezi itatu, mlingo umawerengeredwa molingana ndi izi:

• kuchuluka kwa thupi zosakwana 4 makilogalamu: Amoxiclav amaperekedwa mu mlingo wa 30 mg / kg (poganizira kutembenuka kwa mankhwala onse) maola 12 aliwonse,
• Kulemera kwa 4 makilogalamu: Amoxiclav amaperekedwa pa mlingo wa 30 mg / kg (poganizira kutembenuka kwa mankhwala onse) maola 8 aliwonse.

Ana omwe sanafike pamiyezi itatu, jekeseni amayenera kuperekedwa pang'onopang'ono kulowetsedwa kwa mphindi 30 mpaka 40.

Kwa ana omwe kulemera kwa thupi lawo sikuposa 40 kg, mlingo umasankhidwa poganizira kulemera kwa thupi.

Kwa ana kuyambira miyezi itatu mpaka 12, mankhwalawa amaperekedwa pa mlingo wa 30 mg / kg thupi (malinga ndi mankhwala onse) maola 8 aliwonse, ndipo ngati pali vuto lalikulu, maola 6 aliwonse.

Mu ana omwe ali ndi vuto la impso, mungafunike kusintha kwa mankhwalawa poyerekeza ndi mlingo woyenera wa amoxicillin. Ngati mwa chilolezo cha odwala oterewa amaposa 30 ml / mphindi, kusintha kwa mlingo ndi koyenera. Nthawi zina, mwa ana omwe kulemera kwa thupi lawo sikuposa 40 kg, kugwiritsa ntchito Amoxiclav pazinthu zotsatirazi tikulimbikitsidwa:

• KK 10-30 ml / mphindi: 25 mg / 5 mg pa kilogalamu imodzi ya kulemera kwa maola 12 aliwonse,
• CC zosakwana 10 ml / mphindi: 25 mg / 5 mg pa 1 kg ya kulemera kwamaola 24 aliwonse,
• hemodialysis: 25 mg / 5 mg pa 1 makilogalamu a kulemera kwa thupi maola 24 aliwonse limodzi ndi mlingo wowonjezera wa 12.5 mg / 2,5 mg pa 1 kg ya kulemera kwa thupi kumapeto kwa gawo la dialysis (lomwe limakhudzana ndi kuchepa kwa kuchuluka kwa clavulanic acid ndi amoxicillin mu seramu yamagazi).

30 mg iliyonse ya mankhwalawa imakhala ndi 25 mg ya amoxicillin ndi 5 mg ya clavulanic acid.

Kwa akulu ndi ana opitirira zaka 12 kapena kulemera koposa 40 makilogalamu, Amoxiclav amatumizidwa pa mlingo wa 1200 mg wa mankhwala (1000 mg + 200 mg) maola 8 aliwonse, komanso ngati pali vuto la matenda opatsirana - maola 6 aliwonse.

Amoxiclav imafotokozedwanso kuti athandize opaleshoni mu prophylactic mlingo, omwe nthawi zambiri amakhala 1200 mg wokhudzana ndi opaleshoni pakuchitika komwe opaleshoni imatha maola osakwana 2. Ndi chithandizo chachitali chopitilira, wodwalayo amalandira mankhwalawa 1200 mg mpaka 4 pa tsiku limodzi.

Odwala omwe ali ndi vuto la aimpso, mlingo ndi / kapena nthawi pakati pa amoxiclav iyenera kusintha malinga ndi kuchuluka kwa vuto laimpso molingana ndi malangizo awa:

• CC oposa 30 ml / mphindi: palibe chifukwa chosinthira mlingo,
• KK 10-30 ml / min: mlingo woyamba ndi 1200 mg (1000 mg + 200 mg), pambuyo pake mankhwala amathandizidwa pamitsempha ya 600 mg (500 mg + 100 mg) maola 12 aliwonse,
• CC zosakwana 10 ml / mphindi: mlingo woyamba ndi 1200 mg (1000 mg + 200 mg), pambuyo pake mankhwala amathandizidwa pamitsempha ya 600 mg (500 mg + 100 mg) maola 24 aliwonse,
• Anuria: imeneyi pakati pa jakisoni wa mankhwalawa iyenera kuwonjezeka mpaka maola 48 kapena kuposerapo.

Popeza munthawi ya hemodialysis mpaka 85% ya mankhwala a Amoxiclav amachotsedwa, kumapeto kwa gawo lililonse, mlingo woyenera wa jakisoni uyenera kuperekedwa. Ndi peritoneal dialysis, palibe chifukwa chosinthira mlingo.

Kutalika kwa nthawi ya mankhwalawa ndiku kuyambira masiku 5 mpaka 14 (adokotala yekha ndi omwe angadziwe nthawi yake). Ndi kuchepa kwa kuopsa kwa zizindikiro, kusintha kwa mitundu yamkamwa ya Amoxiclav ndikulimbikitsidwa ndikupitiliza chithandizo.

Pokonzekera jakisoni, zomwe zili mu vial mu kuchuluka kwa 600 mg (500 mg + 100 mg) zimasungunuka mu 10 ml ya madzi a jekeseni, ndipo kuchuluka kwa 1200 mg (1000 mg + 200 mg) mu 20 ml ya madzi a jakisoni (voliyumu iyi siyikulimbikitsidwa) pitirira). Mankhwalawa amaperekedwa pang'onopang'ono kudzera m'mitsempha yoposa 3-4, ndipo kuyambitsidwa kuyenera kuchitika pakatha mphindi 20 pambuyo pokonzekera yankho.

Amoxiclav solution ingagwiritsidwenso ntchito kulowetsedwa kwa mtsempha. Pankhaniyi, mayankho okonzekera omwe ali ndi 1200 mg (1000 mg + 200 mg) kapena 600 mg (500 mg + 100 mg) a mankhwalawa amawonjezeranso mu 100 ml kapena 50 ml ya kulowetsedwa, motero. Kutalika kwa kulowetsedwa kumafika mphindi 30 mpaka 40.

Kugwiritsa ntchito zakumwa zotsatirazi pazomwe zimakulimbikitsani kumakuthandizani kuti musunge zofunika kuzungulira za amoxicillin mu kulowetsedwa. Nthawi yawo yokhazikika imasiyana:

• kwa madzi a jakisoni: Maola 4 pa 25 ° C ndi maola 8 pa 5 ° C,
• yankho la sodium kolorayidi ndi calcium chloride wa kulowetsedwa: 3 hours 25 25 C,
• Yankho la ringer wa lactate wa kulowetsedwa: maola atatu pa 25 ° C,
• kwa sodium chloride 0,9% ya kulowetsedwa kwa mtsempha: maola 4 pa 25 ° C ndi maola 8 pa 5 ° C.

Yankho la Amoxiclav siliyenera kusakanikirana ndi sodium bicarbonate, dextran kapena dextrose. Mayankho omveka okha ndi omwe ayenera kuperekedwa. Njira yokonzekera siyenera kuzizira.

Kukopa pa kuthekera koyendetsa magalimoto ndi njira zowerengeka

Ngati munthawi ya chithandizo ndi mankhwalawa wodwala wapezeka ndi vuto losagwirizana ndi dongosolo lamkati (mwachitsanzo, kupweteka kapena chizungulire), tikulimbikitsidwa kuti tisayendetse magalimoto ndikuchita ntchito yomwe imafuna chidwi chochulukirapo komanso chisamaliro cha psychomotor.

Mimba komanso kuyamwa

Pazoyesa zazinyama, kuvulaza kwa kutenga Amoxiclav pa nthawi yomwe ali ndi pakati komanso momwe mankhwala amakhudzira fetus wa mwana wosabadwa sikutsimikiziridwa. Kafukufuku amodzi wokhudza azimayi omwe ali ndi vuto la zamkati mwachangu, zidapezeka kuti kugwiritsa ntchito prophylactic kuphatikiza kwa amoxicillin ndi clavulanic acid kungakulitse chiopsezo cha necrotizing enterocolitis mu akhanda.

Pa nthawi yoyembekezera komanso mkaka wa m'mawere, kugwiritsa ntchito Amoxiclav kumalimbikitsidwa pokhapokha ngati phindu la mankhwalawo lingathe chifukwa cha thanzi la mwana wosabadwayo ndi mwana. Clavulanic acid ndi amoxicillin ang'onoang'ono amatsimikiza mu mkaka wa m'mawere. Mu makanda omwe ali pachifuwa, kutsegula m'mimba, kuchepa kwa chidwi, michere ya mucous yamkamwa imatha kukhazikika, kotero ngati kuli koyenera kuchitira ndi mankhwala, ndikofunika kusiya kuyamwitsa.

Ndi mkhutu aimpso ntchito

Odwala omwe amalephera kupezeka ndi aimpso (CC amasiyana ndi 10 mpaka 30 ml / min) akulangizidwa kuti amwe mapiritsi a Amoxiclav 1 (mlingo wa 500 mg / 125 mg kapena 250 mg / 125 mg kutengera kuopsa kwa matendawa) maola 12 aliwonse, ndipo kulephera kwambiri kwaimpso (CC ndi ochepera 10 ml / mphindi) - piritsi limodzi (500 mg / 125 mg kapena 250 mg / 125 mg kutengera kuopsa kwa matendawa) maola 24 aliwonse.

Mlingo woyamba wa yankho la intravenous makonzedwe ndi CC a 10-30 ml / mphindi ndi 1000 mg / 200 mg, ndiye 500 mg / 100 mg maola 12 aliwonse. Ndi CC ochepera 10 ml / min, muyezo woyamba wa yankho la intravenous makonzedwe ndi 1000 mg / 200 mg, ndiye 500 mg / 100 mg maola 24 aliwonse.

Ku anuria, gawo pakati pa Mlingo wa Amoxiclav limakulitsidwa mpaka maola 48 kapena kupitilira apo.

Kuyanjana kwa mankhwala

Kudya kwa ascorbic acid limodzi ndi Amoxiclav kumathandizira kuyamwa kwa zinthu zomwe zimagwira, komanso kudya kwa aminoglycosides, maantacid, mankhwala othandizira, mankhwala osokoneza bongo, glucosamine - kumachepetsa mayamwidwe awo. Kugwiritsa ntchito mankhwala osokoneza bongo a anti-yotupa (NSAIDs), diuretics, phenylbutazone, allopurinol ndi mankhwala ena omwe amatseka tubular secretion (phenenecid) kumawonjezera kuchuluka kwa amoxicillin m'thupi (clavulanic acid imachotsedwa makamaka kudzera mu kusefera kwa glomerular). Kuphatikizidwa kwa Amoxiclav ndi phenenecid kumatha kubweretsa kuchuluka kwa magazi ndi kuchuluka kwa amoxicillin, koma osati clavulanic acid, kotero kugwiritsa ntchito munthawi yomweyo kumaletsedwa.

Kuphatikiza kwa amoxicillin, clavulanic acid ndi methotrexate kumathandizira poizoni wa methotrexate. Kugwiritsa ntchito mankhwalawa limodzi ndi allopurinol kumatha kupangitsa khungu kusokonezeka. Sikulimbikitsidwa kupereka Amoxiclav molumikizana ndi disulfiram.

Kuphatikiza kwa amoxicillin ndi clavulanic acid kumachepetsa mphamvu ya mankhwala omwe metabolism yake imayambitsa mapangidwe a para-aminobenzoic acid, ndipo akatengedwa ndi ethinyl estradiol, chiopsezo chotenga magazi "ochulukirapo" ukuwonjezeka.

M'mabukuwa, mumakhala malipoti ochepa akuwonjezeka kwa kuchuluka kwa mitundu yonse ya mankhwala (INR) mwa odwala omwe amapezeka munthawi yomweyo amoxicillin ndi warfarin kapena acenocoumarol. Ngati pakufunika kuphatikiza Amoxiclav ndi anticoagulants, kuwunika nthawi zonse kwa INR kapena prothrombin nthawi ndikulimbikitsidwa mukamasiya kapena kuyamba kulandira mankhwala, popeza kusintha kwa ma anticoagulants pamlomo kungafunike.

Kugwirizana kwa amoxicillin / clavulanic acid wokhala ndi rifampicin kungayambitse kufooka kwa antibacterial. Amoxiclav osavomerezeka ngakhale kamodzi kuphatikiza ndi bacteriostatic antibayotiki (tetracyclines, macrolides) ndi sulfonamides chifukwa cha kuchepa kwa mphamvu ya amoxicillin / clavulanic acid.

Kumwa mankhwalawa kumachepetsa mphamvu yolerera pakamwa. Odwala omwe amatenga mycophenolate mofetil, atayamba kulandira chithandizo ndi Amoxiclav, pali kuchepa kwa zomwe zimagwira metabolite m'thupi - mycophenolic acid - musanamwe mlingo wotsatira wa mankhwalawa pafupifupi 50%. Kusintha kwa mndandandawo sikungawonetse moyenera kusintha kwakanthawi pakuwonekera kwa metabolite iyi.

Amoxiclav analogu ndi:

• Mwa yogwira - Bactoclav, Clamosar, Arlet, Panklav, Medoklav, Liklav, Augmentin, Rapiklav, Fibell, Ekoklav, Amovikomb, Amoksivan,
• Mwa makina ochitira - Libacil, Oxamp, Santaz, Ampiok, Tazotsin, Timentin, Sulacillin, Ampisid.

Mtengo wa Amoxiclav m'mafakisi

Mtengo woyenera wa Amoxiclav mwanjira ya mapiritsi okhala ndi 875 mg / 125 mg ndi 401- 736 ma ruble (14 pa paketi), mulingo wa 500 mg / 125 mg ndi 330-9999 rubles (15 phukusi), 250 mg / 125 mg - 170‒241 ma ruble (phukusi lili ndi ma pc 15.). Ufa pakukonzekera kuyimitsidwa kwa makonzedwe amkamwa ndi mulingo wa 400 mg / 57 mg ungagulidwe kwa ma ruble pafupifupi 158-273, mlingo wa 250 mg / 62,5 mg wa 212-299 rubles, Mlingo wa 125 mg / 31.25 mg - 99-123 rubles . Ufa pakukonzekera jekeseni wa jakisoni ndi Mlingo wa 1000 mg / 200 mg umatha pafupifupi ma ruble 675-862, ndi mulingo wa 500 mg / 100 mg - 465-490 rubles (phukusi lililonse lili ndi mabotolo asanu).

Mitu ya mankhwalawa

Zofanizo zonse za Amoxiclav ndizophatikizira mankhwala okhala ndi amoxicillin ndi clavulanic acid, mwachitsanzo, Augmentin, Flemoklav Solutab. Kukonzekera komwe kuli amoxicillin kokha sikungasinthe m'malo chifukwa mndandanda wa tizilombo tating'onoting'ono tokhala ndi amoxicillin wocheperako ndi wocheperako kuposa Amoxiclav. Zomwezi zitha kunenedwa za mankhwala ena a penicillin gulu - kuchuluka kwawo kogwiritsa ntchito sikungagwirizane ndi kukula kwa kugwiritsa ntchito Amoxiclav.

Mlingo

Mapiritsi okhala ndi mafilimu

Zinthu zothandizira (pakati): Piritsi lililonse la 250mg + 125mg lili ndi 250 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid mu mawonekedwe a mchere wa potaziyamu,
piritsi lililonse la 500 mg + 125 mg lili ndi 500 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid mu mawonekedwe a mchere wa potaziyamu.
piritsi lililonse la 875 mg + 125 mg limakhala ndi 875 mg ya amoxicillin mu mawonekedwe a trihydrate ndi 125 mg ya clavulanic acid momwe amapangira mchere wa potaziyamu.
Omwe amalandira chithandizo (chimodzimodzi pa kipimo chilichonse): colloidal silicon diokosi 5.40 mg / 9.00 mg / 12.00 mg, crospovidone 27.40 mg / 45.00 mg / 61.00 mg, croscarmellose sodium 27.40 mg / 35.00 mg / 47,00, magnesium stearate 12,00 mg / 20,00 mg / 17.22 mg, talc 13.40 mg (kwa 250 mg + 125 mg), cellcose ya microcrystalline mpaka 650 mg / mpaka 1060 mg / mpaka 1435 mg,
makanema othandizira mafilimu 250mg + 125mg - hypromellose 14.378 mg, ethyl cellulose 0,702 mg, polysorbate 80 - 0,780 mg, triethyl citrate 0,793 mg, titanium dioxide 7.605 mg, talc 1.742 mg,
makanema othandizira mafilimu 500mg + 125mg - hypromellose 17.696 mg, ethyl cellulose 0,864 mg, polysorbate 80 - 0.960 mg, triethyl citrate 0,976 mg, titanium dioxide 9.360 mg, talc 2.144 mg,
makanema othandizira mafilimu 875mg + 125mg - hypromellose 23.226 mg, ethyl cellulose 1.134 mg, polysorbate 80 - 1,260 mg, triethyl citrate 1.280 mg, titanium dioxide 12.286 mg, talc 2.814 mg.

Kufotokozera

Mapiritsi a 250 mg + 125 mg: oyera kapena pafupifupi oyera, oblong, octagonal, biconvex, mapiritsi okhala ndi mafilimu okhala ndi prints 250/25 mbali imodzi ndi AMC mbali inayo.
Mapiritsi 500 mg + 125 mg: oyera kapena pafupifupi oyera, oval, mapiritsi a biconvex, filimu yokutira.
Mapiritsi a 875 mg + 125 mg: oyera kapena pafupifupi oyera, oblong, biconvex, mapiritsi okhala ndi mafilimu okhala ndi notch komanso chithunzi cha "875/125" mbali imodzi ndi "AMC" mbali inayo.
Onani pa kink: misa yachikasu.

Mankhwala

Mankhwala
Njira yamachitidwe
Amoxicillin ndi penicillin wopanga yemwe amagwira ntchito motsutsana ndi michere yambiri yama gramu-gram komanso yoyipa. Amoxicillin amasokoneza biosynthesis ya peptidoglycan, yomwe ndi gawo lachipangidwe cha khoma la bakiteriya. Kuphwanya kapangidwe ka peptidoglycan kumabweretsa kuwonongeka kwa mphamvu ya khungu, komwe kumayambitsa lasis ndi kufa kwama cellorganism. Nthawi yomweyo, amoxicillin amatha kuwonongedwa ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira tizilombo tomwe timatulutsa timadzi tambiri.
Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imakhala ndi mphamvu yokwanira yolimbana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukokana kwa bakiteriya, ndipo siigwira ntchito motsutsana ndi mtundu I chromosome beta-lactamases, womwe suletsedwa ndi clavulanic acid.
Kupezeka kwa clavulanic acid pakukonzekera kumateteza amoxicillin kuti asawonongeke ndi ma enzymes - beta-lactamases, omwe amalola kukula kwa antibacterial sipekitiramu ya amoxicillin.
Otsatirawa ndi ntchito ya vitro yosakanikirana ya amoxicillin yokhala ndi clavulanic acid.

Pharmacokinetics
Magawo akuluakulu a pharmacokinetic a amoxicillin ndi clavulanic acid ndi ofanana. Amoxicillin ndi clavulanic acid amasungunuka bwino m'mayankho amadzimadzi ndi pH yamoyo ndipo atatha kumwa Amoxiclav ® mkati, amatengeka mwachangu komanso kuchokera m'matumbo a m'mimba (GIT). Kuyamwa kwa yogwira zinthu za amoxicillin ndi clavulanic acid ndi bwino ngati amamwa kumayambiriro kwa chakudya.
The bioavailability wa amoxicillin ndi clavulanic acid pambuyo pakamwa makonzedwe ali pafupifupi 70%.
Ma paracokinetic magawo a amoxicillin ndi clavulanic acid amaperekedwa pansipa pambuyo pa utsogoleri wa 875 mg / 125 mg ndi 500 mg / 125 mg kawiri patsiku, 250 mg / 125 mg katatu patsiku ndi odzipereka athanzi.

Kugawa
Onsewa amakhala ndi kuchuluka kwabwino kugawa zosiyanasiyana ziwalo, zimakhala ndi madzi amthupi (kuphatikiza m'mapapo, ziwalo zam'mimbamo, adipose, mafupa ndi minofu minofu, pleural, synovial ndi peritoneal fluid, pakhungu, bile, mkodzo, mafinya kumaliseche, sputum, mu madzi mkati.
Kumanga mapuloteni a Plasma ndiwofatsa: 25% ya clavulanic acid ndi 18% ya amoxicillin.
Voliyumu yogawa ndi pafupifupi 0.3-0.4 L / kg ya amoxicillin ndi pafupifupi 0,2 L / kg ya clavulanic acid.
Amoxicillin ndi clavulanic acid samadutsa chotchinga magazi mu maukonde osavulala.
Amoxicillin (monga ma penicillin ambiri) amathandizidwa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere. Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.
Kupenda
Pafupifupi 10-25% ya koyamba mlingo wa amoxicillin umatheka ndi impso mu mawonekedwe a ofooka a penicilloic acid. Clavulanic acid m'thupi la munthu imakhala imapangidwa mwamphamvu kwambiri pakupanga 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-imodzi ndikufotokozedwanso ndi impso, kudzera m'mimba, komanso ndi mpweya wotulutsidwa, ngati mpweya wa kaboni.
Kuswana
Amoxicillin amachotseredwa makamaka ndi impso, pomwe clavulanic acid kudzera munthawi zonse amatsempha a impso ndi owonjezera. Pambuyo pakamwa limodzi lokha piritsi limodzi la 250 mg / 125 mg kapena 500 mg / 125 mg, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osabereka ndi impso nthawi yayitali 6.
Pafupifupi theka la moyo (T1 / 2) wa amoxicillin / clavulanic acid ndi pafupifupi ola limodzi; kuvomerezeka kwathunthu kumakhala pafupifupi 25 l / h kwa odwala athanzi.
Kuchuluka kwa asidi wa clavulanic kumakhudzidwa nthawi yoyamba ya 2 pambuyo pa ntchito.
Odwala ndi mkhutu aimpso ntchito
Chilolezo chonse cha amoxicillin / clavulanic acid chimachepera mogwirizana ndi kuchepa kwa impso. Chilolezo chocheperako chimatchulidwa kuti amoxicillin kuposa clavulanic acid, chifukwa ambiri a amoxicillin amamuchotsa impso. Mlingo wa mankhwala aimpso kulephera kuyenera kusankhidwa chifukwa cha kuchepa kwa kuchuluka kwa amoxicillin kwinaku ndikusintha kwacudiulanic acid.
Odwala omwe ali ndi vuto la chiwindi
Odwala omwe ali ndi vuto la chiwindi, mankhwalawa amagwiritsidwa ntchito mosamala, ndikofunikira kuyang'anira ntchito ya chiwindi nthawi zonse.
Zonsezi zimachotsedwa ndi hemodialysis ndi zochepa pang'onopang'ono ndi peritoneal dialysis.

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Kafukufuku wazinyama sanawululire zowopsa za kumwa mankhwalawa panthawi yomwe ali ndi pakati komanso momwe zimakhudzira kukula kwa fetal.
Kafukufuku wina mwa azimayi omwe ali ndi matendawa asanakwane, zimapezeka kuti kugwiritsa ntchito prophylactic wa amoxicillin / clavulanic acid kumatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mu akhanda.
Pa nthawi yoyembekezera komanso mkaka wa m'mawere, mankhwalawa amagwiritsidwa ntchito pokhapokha ngati phindu lomwe limaperekedwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo ndi mwana.
Amoxicillin ndi clavulanic acid ochepa omwe amalowa mkaka wa m'mawere.
Mu makanda omwe amalandila yoyamwitsa, kukula kwa chidwi, kutsegula m'mimba, ma micidi a mucous nembanemba amkamwa amatha. Mukamamwa Amoxiclav ®, ndikofunikira kusankha pakuletsa kuyamwitsa.

Zotsatira zoyipa

Malinga ndi World Health Organisation (WHO), zotsatira zosafunikira zimagawidwa malinga ndi kuchuluka kwa chitukuko motere: Nthawi zambiri (≥1 / 10), nthawi zambiri (≥1 / 100, kuchokera m'matumbo am'mimba
nthawi zambiri: kutsegula m'mimba
Nthawi zambiri: kusanza, kusanza. Khansa ya msana imawonedwa kwambiri tikamayamwa.
Ngati kuphwanya kwam'mimba kumatsimikiziridwa, kumatha kutha ngati mutamwa mankhwalawa koyambirira kwa chakudya.
kawirikawiri: kugaya chakudya
kawirikawiri anti-anti-colitis (kuphatikiza hemorrhagic colitis ndi pseudomembranous colitis), lilime "lakuda", gastritis, stomatitis.
Pa mbali ya chiwindi ndi biliary thirakiti
kawirikawiri: kuchuluka kwa alanine aminotransferase (ALT) ndi / kapena aspartate aminotransferase (AST). Izi zimawonedwa mwa odwala omwe amalandila beta-lactam antiotic therapy, koma kufunikira kwake kwachipatala sikudziwika.
kawirikawiri cholestatic jaundice, chiwindi, kuchuluka kwa zamchere phosphatase, kuchuluka kwa bilirubin mu madzi am`magazi.
Zotsatira zoyipa za chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo amatha kuyanjana ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.
Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zotsatira zoyipa nthawi zambiri zimatha kusintha.
Zotsatira zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali anthu omwe anali ndi vuto lalitali kapena omwe amamwa nthawi yomweyo mankhwala a hepatotoxic.
Kuchokera ku chitetezo chamthupi
kawirikawiri angioedema, anaphylactic zimachitika, matupi awo saviyo vasculitis,
Pa gawo lamwazi ndi zamitsempha yamagazi
osati kawirikawiri: leukopenia wosinthika (kuphatikizapo neutropenia), thrombocytopenia,
kawirikawiri reversible agranulocytosis, hemolytic anemia, kuchuluka kosinthika kwa prothrombin nthawi, kuchuluka kosintha kwa nthawi ya magazi (onani gawo "Special Instructions"), eosinophilia, thrombocytosis.
Kuchokera ku dongosolo lamanjenje
kawirikawiri: chizungulire, kupweteka mutu,
kawirikawiri kukomoka (kumachitika kwa odwala ndi mkhutu aimpso ntchito, komanso kumwa mankhwalawa.), kusinthanso kwamphamvu, aseptic meningitis, nkhawa, kusowa tulo, kusintha kwa mikhalidwe, kukwiya.
Pa khungu ndi subcutaneous minofu
kawirikawiri: zotupa pakhungu, pruritus, urticaria,
osati kawirikawiri: erythema multiforme exudative,
kawirikawiri exfoliative dermatitis, Stevens-Johnson syndrome, pachimake chachikulu pustulosis, matenda ofanana ndi seramu matenda, poizoni epidermal necrolysis.
Kuchokera impso ndi kwamikodzo
kawirikawiri interstitial nephritis, crystalluria (onani gawo "Overdose"), hematuria.
Matenda opatsirana komanso parasitic
Nthawi zambiri: candidiasis a pakhungu ndi mucous nembanemba.
Zina
maulendo osadziwika: kukula kwa tizilombo tating'onoting'ono.

Wopanga

Wogwira RU: Lek dd, Verovshkova 57, 1526 Ljubljana, Slovenia,
Amapangidwa: Lek dd, Perzonali 47, 2391 Prevale, Slovenia.
Zodandaula za ogula ziyenera kutumizidwa ku ZAO Sandoz:
125315, Moscow, Leningradsky Prospekt, 72, bldg. 3.