Liprimar ndi kufanana kwake, malingaliro ndi zosankha

Inde, ma statin onse amapangidwa kuti azikhala ndi nthawi yayitali (kuphatikizapo nthawi yayitali). Ngati iye mwa wodwala makamaka amachepetsa cholesterol ndipo sayambitsa kuwonjezeka kwa ALT ndi AST (ma enzymes a chiwindi poyesa magazi), mutha kupitiliza kumwa. Kuphatikiza apo, kamodzi miyezi isanu ndi umodzi, muyenera kubwereza kuyesa kwa magazi kwa lipid mbiri (cholesterol), ALT, AST.

Liprimar: pharmacological zochita, zikuchokera, mavuto

Liprimar (wopanga Pfizer, dziko la Germany) ndi dzina lolembetsedwa logwiritsira ntchito mankhwala ochepetsa lipid. Zomwe zimagwirira ntchito mmenemo ndi atorvastatin. Ichi ndi mankhwala ochokera ku gulu la zopangidwa ma statins zomwe zimakhudza cholesterol yamagazi ndi triglycerides.

Lypimar ya mankhwala amachepetsa zomwe zimadziwika kuti "zoipa" cholesterol ndikuwonjezera zomwe zili "zabwino", zimalimbikitsa kuchepa kwa magazi ndikuchepetsa kutupa kwa mitsempha yamagazi, zimalepheretsa magazi kuwundana komanso ndi njira yothandiza yolimbana ndi matenda a mtima.

Njira yotulutsira lypimar ndi piritsi lamlonda. Mlingo wa atorvastatin mwa iwo ukhoza kukhala 10, 20, 40 ndi 80 mg, monga momwe zalembedwera pa piritsi iliyonse ilili.

Kuphatikiza apo, kukonzekera kumakhala ndi zinthu zothandizira: calcium carbonate, magnesium stearate, croscarmellose sodium, hypromellose, lactose monohydrate, hydroxypropyl cellulose, titanium dioxide, talc, simethicone emulsion.

Mapiritsi a kutafuna sayenera kukhala. Ndiwophatikizidwa. Piritsi limodzi limagwira tsiku limodzi kapena kupitirira. Wodwala aliyense amapatsidwa mlingo. Ngati mankhwala osokoneza bongo apezeka, chotupa cha m'mimba chiyenera kuchitidwa ndipo adokotala azifunsidwa nthawi yomweyo.

Liprimar: Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa ndi matenda otsatirawa:

• hypercholesterolemia,
• kuphatikiza mtundu wophatikizira,
• dysbetalipoproteinemia,
• hypertriglyceridemia,
• magulu omwe ali pachiwopsezo chotenga matenda a mtima ((anthu opitilira 55, osuta, odwala matenda ashuga, matenda obadwa nawo, matenda oopsa ndi ena),
• matenda a mtima.

Mutha kutsitsa cholesterol, kuwona kadyedwe, maphunziro olimbitsa thupi, kunenepa kwambiri mwa kutaya thupi owonjezera, ngati izi sizipereka zotsatira, perekani mankhwala omwe amachepetsa cholesterol.

Ndikofunikira kutsatira malangizo ogwiritsira ntchito Liprimar. Palibe malire a nthawi oti amwe mapiritsiwo. Kutengera ndi zomwe zikuwonetsa LDL (cholesterol yoyipa), mlingo wa tsiku ndi tsiku wa mankhwalawa (nthawi zambiri 10-80 mg) umawerengeredwa. Wodwala wokhala ndi mawonekedwe oyamba a hypercholesterolemia kapena kuphatikiza hyperlipidemia ndi mankhwala 10 mg, omwe amatengedwa tsiku lililonse kwa masabata 2-4. Odwala akudwala cholowa hypercholesterolemia ndi mankhwala okwanira 80 mg.

Sankhani Mlingo wa mankhwala omwe amakhudza metabolism yamafuta amayenera kuyang'aniridwa ndi milingo ya lipid m'magazi.

Mochenjera, mankhwalawa amalembedwa kwa odwala omwe ali ndi vuto la chiwindi kapena chikugwirizana ndi cyclosparin (osapitirira 10 mg patsiku), akuvutika ndi matenda a impso, odwala omwe ali ndi zaka zochepetsedwa Mlingo safunika.

Kupanga ndi mawonekedwe a kumasulidwa

Wopezeka mu mawonekedwe a mapiritsi, m'matumba a zidutswa za 7-10, kuchuluka kwa matuza omwe ali phukusili ndizosiyana, kuyambira 2 mpaka 10. Chomwe chimagwira ndi mchere wa calcium (atorvastatin) ndi zinthu zina zowonjezera: croscarmellose sodium, calcium carbonate, wax hyprolose, lactose monohydrate, polysorbate-80, oyera opadra, magnesium stearate, simethicone emulsion.

Mapiritsi a Elliptical Liprimar omwe amapangidwa ndi chipolopolo choyera, kutengera mlingo wa milligram, ali ndi zolemba za 10, 20, 40 kapena 80.

Zothandiza katundu

Chuma chachikulu cha Liprimar ndi hypolipidemia. Mankhwala amathandizira kuchepetsa kupanga ma enzyme omwe amachititsa kuti mafuta azigwiritsa ntchito cholesterol. Izi zimabweretsa kuchepa pakupanga cholesterol ndi chiwindi, motero, mulingo wake m'magazi umachepa, ndipo ntchito yamtima imayenda bwino.

Mankhwalawa amalembedwa kwa anthu omwe ali ndi hypercholesterolemia, zakudya zosachiritsika komanso mankhwala ena ochepetsa mafuta m'thupi. Pambuyo popita kuthandizira, kuchuluka kwa cholesterol kumatsika ndi 30-45%, ndi LDL - ndi 40-60%, ndipo kuchuluka kwa lipoprotein m'magazi kumachuluka.

Kugwiritsa ntchito Liprimar kumathandizira kuchepetsa kufalikira kwa zovuta zamatenda a ischemic ndi 15%, kufa kuchokera ku mtima pathologies kumachepa, ndipo chiwopsezo cha kugunda kwamtima ndi kuwopsa kwa angina chimachepetsedwa ndi 25%. Katundu wa Mutagenic ndi carcinogenic sanapezeke.

Zotsatira zoyipa za Liprimara

Monga mankhwala aliwonse, awa imakhala ndi mavuto. Kwa Liprimar, malangizo ogwiritsira ntchito akuwonetsa kuti nthawi zambiri amaloledwa. Komabe, zingapo zoyipa zimadziwika: kusowa tulo, matenda a kutopa kwambiri (asthenia), kupweteka m'mimba, kupweteka kwam'mimba, kutsegula m'mimba ndi dyspepsia, bloating (flatulence) ndi kudzimbidwa, myalgia, nseru.

Zizindikiro za anaphylaxis, anorexia, arthralgia, kupweteka kwa minofu ndi kukokana, hypo- kapena hyperglycemia, chizungulire, jaundice, zotupa pakhungu, kuchepa kwa magazi, kuchepa kwa magazi, kuchepa kwa kukumbukira, kuchepa mphamvu, kusanza sikunachitike. thrombocytopenia.

Zotsatira zoyipa za Liprimar, monga kufupika kwa malekezero, kunenepa kwambiri, kupweteka pachifuwa, alopecia, tinnitus, ndi kukula kwa kulephera kwa aimpso, adatinso.

Contraindication

Kwa odwala omwe ali ndi hypersensitivity pazinthu zomwe zimapanga Liprimar, mankhwalawa amatsutsana. Sichimakhazikitsidwa kwa ana osakwana zaka 18. Odwala omwe ali ndi matenda othandizira a hepatic kapena omwe ali ndi milingo yayitali ya transaminases m'magazi a etiology osadziwika.

Opanga Liprimar amaletsa kugwiritsa ntchito mankhwalawa panthawi ya mkaka ndi pakati. Amayi a msinkhu wobereka ayenera kugwiritsa ntchito njira zakulera panthawi yamankhwala. Kupezeka kwa mimba pa nthawi ya mankhwala ndi mankhwalawa ndikosayenera kwambiri, chifukwa zovuta zomwe zimabweretsa chitukuko cha mwana wosabadwayo.

Mankhwala ayenera kuikidwa mosamala anthu omwe ali ndi mbiri ya matenda a chiwindi kapena uchidakwa.

Mbale

Atorvastatin - analogue ya Liprimar - ndi amodzi mwa mankhwala odziwika kwambiri ochepetsa kupsinjika kwa lipoproteins. Kuyesedwa kochitidwa ndi Grace ndi 4S kunawonetsa kukula kwa atorvastatin kupitilira simvastatin poletsa kukula kwa ngozi ya mtima wamatenda komanso sitiroko. Pansipa timaganizira za mankhwala a gulu la statin.

Zinthu zopangidwa ndi Atorvastatin

Analogue yaku Russia ya Liprimar, Atorvastatin, imapangidwa ndi makampani opanga mankhwala: Kanofarma Production, ALSI Pharma, Vertex. Mapiritsi amlomo wokhala ndi mulingo wa 10, 20, 40 kapena 80 mg. Tengani kamodzi patsiku pafupifupi nthawi yomweyo, osadya.

Nthawi zambiri makasitomala amadzifunsa - Atorvastatin kapena Liprimar - ndibwino?

Mankhwala at "Atorvastatin" ali ofanana ndi machitidwe a "Liprimar", chifukwa mankhwalawo ali ndi maziko ofanana. Limagwirira ntchito cha woyamba mankhwala umalimbana kusokoneza kapangidwe kolesterol ndi atherogenic lipoproteins ndi maselo a thupi. Kugwiritsa ntchito kwa LDL m'maselo a chiwindi kumawonjezeka, ndipo kuchuluka kwa kupanga ma anti-atherogenic high-density lipoproteins kumakulanso pang'ono.

Atorvastatin asanaikidwe, wodwalayo amasinthidwa kukhala chakudya ndikumupatsa njira yochita masewera olimbitsa thupi, zimachitika kuti izi zimabweretsa kale zotsatira zabwino, ndiye kuti mankhwala a statins amakhala osafunikira.

Ngati sizotheka kusintha mtundu wa cholesterol osakhala mankhwala, mankhwala a gulu lalikulu la statins ndi omwe amaperekedwa, omwe akuphatikizapo Atorvastatin.

Pa gawo loyamba la mankhwalawa, Atorvastatin amayikidwa 10 mg kamodzi patsiku. Pambuyo pa masabata 3-4, ngati mulingo wosankhidwa mosiyanasiyana, kusintha kwa mawonekedwe a lipid kumaonekera. Mu mbiri ya lipid, kuchepa kwa cholesterol yathunthu kumadziwika, kuchuluka kwa lipoproteins yotsika komanso yotsika kwambiri kumachepa, kuchuluka kwa triglycerides kumachepa.

Ngati mulingo wa zinthu izi sunasinthe kapena ngakhale kuchuluka, ndikofunikira kusintha mlingo wa Atorvastatin. Popeza mankhwalawa amapezeka pamiyeso ingapo, ndikofunikira kwa odwala kuti asinthe. Patatha milungu 4 mutachulukitsa mlingo, kusanthula kwa lipid kumachitika mobwerezabwereza, ngati kuli kotheka, mlingo umakulanso, mlingo waukulu tsiku lililonse ndi 80 mg.

Makina ochitira, Mlingo ndi zoyipa za Liprimar ndi mnzake waku Russia ndizofanana. Ubwino wa Atorvastatin umaphatikizapo mtengo wake wotsika mtengo. Malinga ndi ndemanga, mankhwala a ku Russia nthawi zambiri amayambitsa zovuta komanso chifuwa poyerekeza ndi Liprimar. Chosangalatsa china ndi chithandizo cha nthawi yayitali.

Zina m'malo mwa Liprimar

Atoris - analogue of Liprimar – mankhwala opangidwa ndi kampani yopanga mankhwala ku Slovenia KRKA. Ndiwonso mankhwala ofanana mu mankhwala ake a Liprimaru. Atoris imapezeka ndi mulingo wambiri poyerekeza Liprimar. Izi zimathandizira adokotala kuti athe kuwerengera mosamala mankhwalawo, ndipo wodwalayo atha kumwa mankhwalawo mosavuta.

Atoris ndi mankhwala okhawo a generic (Liprimara generic) omwe adakumana ndi mayesero ambiri azachipatala ndipo adawatsimikizira kuti amagwira ntchito bwino. Odzipereka ochokera kumayiko ambiri anachita nawo kafukufukuyu. Kafukufukuyu adachitika pamaziko a zipatala ndi zipatala. Zotsatira zamaphunziro mu maphunziro 7000 omwe atenga Atoris 10 mg kwa miyezi iwiri, kuchepa kwa atherogenic ndi cholesterol yathunthu ndi 20-25% idadziwika. Kupezeka kwa zoyipa ku Atoris ndizochepa.

Liptonorm ndi mankhwala a ku Russia omwe amateteza kagayidwe ka mafuta m'thupi. Chomwe chimagwira ntchito yake ndi atorvastine, chinthu chomwe chili ndi hypolipidemic ndi hypocholesterolemic kanthu. Liptonorm imakhala ndi zofanana pakugwiritsa ntchito komanso kumwa ndi Liprimar, komanso zovuta zina.

Mankhwalawa amapezeka mu mitundu iwiri yokha ya 10 ndi 20 mg. Izi zimapangitsa kuti ikhale yovuta kugwiritsidwa ntchito ndi odwala omwe ali ndi vuto lochiritsika la atherosulinosis, heterozygous Famer hypercholesterolemia, ayenera kumwa mapiritsi a 4-8 patsiku, popeza tsiku lililonse ndi 80 mg.

Torvacard ndiye analogue wodziwika kwambiri wa Liprimar. Kupanga kampani ya mankhwala ku Slovak "Zentiva". "Torvacard" yakhazikitsa bwino kukonzanso kwa cholesterol kwa odwala omwe ali ndi matenda a mtima. Imagwiritsidwa ntchito bwino pochiza odwala omwe ali ndi vuto la kuchepa kwa magazi komanso kuchepa kwa magazi, komanso kupewa mavuto monga kugwidwa ndi matenda a mtima. Mankhwala amathandizira kuchepetsa kuchuluka kwa triglycerides m'mwazi. Imagwiritsidwa ntchito bwino pochiza matenda amtundu wa dyslipidemia, mwachitsanzo, kuonjezera milingo ya "othandiza" yapamwamba kwambiri ya lipoprotein.

Mitundu yotulutsidwa kwa "Torvokard" 10, 20 ndi 40 mg. Mankhwala a atherosulinosis amayamba, nthawi zambiri amakhala ndi 10 mg, atatha kukhazikitsa mlingo wa triglycerides, cholesterol, lipoproteins wotsika. Pambuyo 2-4 milungu kuchita kusanthula kuwonekera kwa lipid sipekitiramu. Ndi chithandizo cha mankhwala, onjezani mlingo. Mlingo waukulu patsiku ndi 80 mg.

Mosiyana ndi Liprimar, Torvacard imathandiza kwambiri odwala omwe ali ndi matenda a mtima.

Mankhwalawa ndi lypimar. Malangizo ndi mtengo

Mankhwala ochepetsa lipid ayenera kutsatiridwa poyesa kutsitsa cholesterol nawo Kusintha kwa kadyedwe, kakhalidwe, maphunziro azolimbitsa thupi. Izi zikakanika, perekani mankhwala. Musanayambe kumwa mapiritsi a Lyprimar, malangizo ogwiritsira ntchito akuyenera kuwerengedwa osalephera.

Madokotala amalimbikitsa kumwa nthawi zonse, koma mtengo wa mankhwalawo siwotsika kwambiri: rubles 1800. Mapiritsi 100 aliwonse otsika kwambiri a 10 mg. Chifukwa chake, odwala ambiri akufuna ma fanizo a lypimar, omwe ndi otsika mtengo kuposa oyambira, koma ali ndi zotsatira zofananira.

Tisanatchulidwe fanizo la mankhwalawa, timawona kuti ndikofunikira kuchenjeza kuti njira yoyambirira ndi ya Pfizer, ndipo ma analogu omwe ali otsika kwambiri sangakhale ndi zotsatira zoyenera mthupi lanu kapena kuwongolera mawonekedwe osafunikira kwambiri kuposa liprimar. Chifukwa chake, musanalowe m'malo mankhwalawo, pitani kuchipatala.

Liprimar. Zotsatira zoyipa

Uwu ndi m'badwo wachitatu wama statins, motero umagwira thupi mokwanira ndipo umakhala ndi zoyipa zochepa. Awo mawonekedwe amawonekera kwambiri, koma zimachitika. Pogwiritsa ntchito mankhwala kwa nthawi yayitali, kukumbukira komanso kuganiza kumatha kuonekanso, komanso mavuto ammimba, kupweteka kwa minofu, kutopa, kugona, kupweteka kwa mutu, kusokonezeka kwa tulo.

Ndikofunika kukumbukira kuti odwala matenda ashuga amatha kuwonjezera shuga akamamwa mankhwalawa. Potere, adotolo amasankha chofunikira kwambiri kwa wodwala: kuchepa kwa mafuta m'thupi la cholesterol kapena kusunga shuga kukhala wabwinobwino.

Mankhwala ndi lypimar. Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amalembera achikulire ndi ana omwe ali ndi cholesterol yayikulu m'magazi.

Zina zomwe zingasonyeze kuvomerezedwa ndi:

1. Kuteteza mtima,
2. Kupewa stroko
3. Kuteteza kwa Atherosulinosis
4. Matenda oopsa
5. Zinthu pambuyo opaleshoni ya mtima.

Mankhwala contraindicated mu mimba, yoyamwitsa, anthu odwala matenda a chiwindi, ndi tsankho kwa zigawo zikuluzikulu za mankhwala.

Atorvastatin

Mankhwala ofanana ndi dzina lothandizira. Mafakitale ambiri opanga mankhwala ku Russia atorvastatin amapangidwa muyezo wa 10, 20, 40 ndi 80 mg. Imagwiritsidwanso kamodzi patsiku, ngakhale zakudya. Zomwe zimagwira mu lypimar ndi atorvastatin ndizofanana.

Mutha kuwongolera kutha kwa mankhwalawa mwakuwunikira cholesterol patatha mwezi umodzi chiyambireni chithandizo. Ndi mlingo woyenera, kuchepa kwake. Ngati sizili choncho, ndiye kuti adokotala ayenera kusintha mlingo.

Popeza atorvastatin imapezeka pamitundu yosiyanasiyana, kusinthira ku mlingo wapamwamba sikovuta. Pakatha mwezi umodzi, kusanthula kumachitidwanso, ndipo zimafotokozeredwa za njira yomwe angamwe mankhwalawo.

Ndemanga za madotolo za mankhwalawa sizabwino ngati za lymparira woyambirira. Mankhwala akunyumba amataya chifukwa chosachepetsa mphamvu yochepetsa cholesterol ndi zotsatira zoyipa zomwe zimawoneka pachiwindi.

Chifukwa chakuti chida ichi chimapangidwa ku Russia, mtengo wake umakhala wotsika kwambiri. Phukusi la mapiritsi 90 a atorvastatin 10 mg aliyense amawononga ma ruble 450, ndipo mapiritsi 90 a 20 mg aliyense amatenga ma ruble 630. Poyerekeza: lypimar 20 mg, mtengo pa ma PC 100 uli pafupifupi 2500 rubles.

Zomwe zimagwiranso ntchito, wopanga ndi kampani ya Slovenia KRKA. Ali ndi mitundu yambiri: 10, 20, 30, 60, 80 mg. Chifukwa chake, adokotala ali ndi mwayi wambiri posankha mtundu woyenera wa wodwala wina. Generic ndi m'modzi mwa owerengeka omwe kutsimikizika kwake kwatsimikiziridwa, ndipo si koyipa kuposa momwe mankhwalawo adapangidwira.

Kafukufuku adachitika m'maiko ambiri, mayeso adachitika kuzipatala ndi zipatala. Anthu zikwi zisanu ndi ziwiri omwe akutenga atoris adawonetsa kuchepa kwa cholesterol ndi pafupifupi kotala ya zoyambira zoyambirira. Chiwopsezo cha zotsatira zoyipa ndizochepa, monga momwe zilili ndi lypimar.

Kumayambiriro kwa chaka cha 2017paketi ya mapiritsi 90 a atoris 10 mg amawononga ma ruble 650., pa mlingo wa 40 mg, mapiritsi 30 angagulidwe kwa ma ruble 590. Fananizani: liprimar 40 mg (malangizo ogwiritsira ntchito phukusi), mtengo - 1070 rubles.

Wopangayo ndi kampani yaku Russia yotchedwa Pharmstandard. Zinthu zogwira, zofanana ndi lypimar, koma Liptonorm imapezeka mu mitundu iwiri yokha: 10 ndi 20 mg. Chifukwa chake, odwala omwe akufunika kuchuluka kwa mankhwalawa amayenera kumwa mapiritsi angapo: 4 kapena 8.

Tsoka ilo, mndandanda wazotsatira za liptonorm ndiwotakata. Ikhoza kukhala kusowa tulo, chizungulire, glaucoma, kutentha kwa mtima, kudzimbidwa, kutsegula m'mimba, kuchepa kwamatumbo, chikodzo, seborrhea, urticaria, dermatitis, hyperglycemia, kuchuluka kwa thupi, kuchulukitsa kwa gout ndi zina zambiri.

Phukusi la mapiritsi 28 a Liptonorm 20 mg limagula ma ruble 420.

Imodzi mwazodziwika bwino kwambiri zopangidwa ndi generic lypimar. Amapangidwa ku Slovakia ndi Zentiva. Kugwira kwake ntchito kukonza mafuta m'thupi kumatsimikiziridwa, kotero amathandizidwa ndi madokotala. Mlingo: 10, 20, 40 mg.

Kulandila kwa torvakard kumayamba ndi 10 mg patsiku ndikuwunikira pakadutsa mwezi umodzi. Ngati mphamvu zoyenera zadziwika, wodwalayo amapitiliza kumwa mankhwalawo. Kupanda kutero, mlingo ukuwonjezeka. Pazipita tsiku lililonse 80 mg kapena 2 mapiritsi a 40 mg.

Paketi ya mapiritsi 90 a 10 mg a torvacard amawononga pafupifupi ma ruble 700. (Ogasiti 2017)

Rosipuvastatin-wokhala ndi Liprimar analogues

Rosuvastatin ndi mankhwala a mibadwo ya chinayi omwe amasungunuka kwambiri m'magazi ndipo amachepetsa mphamvu ya lipid. Kuwonongeka kochepa kwa chiwindi ndi minofu, chifukwa chake zovuta zoyipa pachiwindi zimachepetsedwa.

Momwe zimachitikira, rosuvastatin ndi ofanana ndi atorvastatin, koma imatha kusintha mwachangu. Zotsatira zakuwongolera kwake zitha kuwerengeka patatha sabata limodzi, zotsatira zabwino kwambiri zimatha kumapeto kwa sabata lachitatu kapena lachinayi.

Mankhwala omwe amadziwika kwambiri ndi rosuvastatin:

• Crestor (Astrazeneca Pharmaceuticals, UK). Mapiritsi 98 a 10 mg amatenga ma ruble 6150.,
• Mertenil (Gideon Richter, Hungary). Mapiritsi 30 a 10 mg amatenga ma ruble 545.,
• Tevastor (Amma, Israel). Mapiritsi 90 a 10 mg amatenga ma ruble 1,100.

Mitengo ili kumayambiriro kwa chaka cha 2017.

Zotsatira za pharmacological

Zopangira lipid-kutsitsa mankhwala. Atorvastatin ndi mpikisano wosankha wa HMG-CoA reductase, ma enzyme ofunikira omwe amasintha 3-hydroxy-3-methylglutaryl-CoA kukhala mevalonate, choyambirira kwa ma steroid, kuphatikiza cholesterol.

Odwala omwe ali ndi homozygous ndi heterozygous Famer hypercholesterolemia, osakhala a mabanja a hypercholesterolemia ndi dyslipidemia, atorvastatin otsika okwana cholesterol (Ch) mu plasma, cholesterol-LDL ndi apolipoprotein B (apo-B), komanso Cuc C. kuchuluka kosasunthika pamlingo wa HDL-C.

Atorvastatin amachepetsa kuchuluka kwa cholesterol ndi lipoproteins m'magazi am'magazi, kuletsa HMG-CoA reductase ndi kaphatikizidwe kolesterol mu chiwindi ndikuwonjezera kuchuluka kwa hepatic LDL receptors pamaselo a cell, zomwe zimayambitsa kuwonjezeka ndikuwonetsa kwa LDL-C.

Atorvastatin amachepetsa kupangika kwa LDL-C ndi kuchuluka kwa tinthu ta LDL. Zimayambitsa kuwonjezeka kosalekeza kwa zochitika za LDL receptors, kuphatikiza pakusintha koyenera mu zinthu za LDL. Amachepetsa mulingo wa LDL-C odwala omwe ali ndi homozygous cholowa hypercholesterolemia, osagwirizana ndi mankhwala ena okhala ndi lipid-kuchepetsa.

Atorvastatin mu Mlingo wa 10-80 mg amachepetsa cholesterol yathunthu ndi 30-46%, LDL-C ndi 41-61%, apo-B ndi 34-50% ndi TG ndi 14-33%. Zotsatira zamankhwala ndizofanana kwa odwala omwe ali ndi heterozygous Famer hypercholesterolemia, omwe siabanja mitundu ya hypercholesterolemia ndi hyperlipidemia kuphatikizapo Odwala odwala matenda a shuga omwe amadalira insulin.

Odwala omwe ali ndi hypertriglyceridemia yotsala, ma atorvastatin amatsitsa cholesterol yonse, Chs-LDL, Chs-VLDL, apo-B ndi TG ndikuwonjezera kuchuluka kwa Chs-HDL. Odwala omwe ali ndi dysbetalipoproteinemia, amachepetsa mulingo wa ChS-STD.

Odwala omwe ali ndi mtundu wa IIa ndi IIb hyperlipoproteinemia malinga ndi gulu la Fredrickson, mtengo wowonjezereka wa HDL-C panthawi ya chithandizo ndi atorvastatin (10-80 mg), poyerekeza ndi mtengo woyambira, ndi 5.1-8.7% ndipo sizimatengera mlingo. Pali kuchepa kwakukulu kosadalira mlingo: cholesterol / Chs-HDL ndi Chs-LDL / Chs-HDL ndi 29-44% ndi 37-55%, motsatana.

Atorvastatin pa mlingo wa 80 mg kwambiri amachepetsa chiopsezo cha ischemic zovuta ndi kufa ndi 16% pambuyo pa maphunziro a sabata 16, ndi chiopsezo chokhazikitsidwanso kuchipatala cha angina pectoris, chotsatira ndi zizindikiro za myocardial ischemia, ndi 26%. Odwala omwe ali ndi misinkhu yosiyanasiyana ya LDL-C, atorvastatin amachititsa kuchepa kwa chiwopsezo cha ischemic ndi kufa (mwa odwala omwe ali ndi myocardial infarction popanda Q wave ndi angina osakhazikika, amuna ndi akazi, odwala ang'ono ndi achikulire kuposa zaka 65).

Kutsika kwa plasma m'magazi a LDL-C kumalumikizidwa bwino ndi mlingo wa mankhwalawo kuposa momwe amapangidwira m'magazi am'magazi.

The achire zotsatira zimatheka patatha masabata awiri chiyambireni kuyambika kwa mankhwalawa, chimafika pakatha masabata 4 ndipo chimapitilira nthawi yonse ya chithandizo.

Mtima Kupewa matenda

Pakufufuzira kwa Anglo-Scandinavia pazotsatira zamtima, lipid-lowering nthambi (ASCOT-LLA), zotsatira za atorvastatin pa matenda oopsa a mtima komanso osapweteka a coronary, zidapezeka kuti zotsatira za chithandizo cha atorvastatin pamlingo wa 10 mg zimadutsa kwambiri zotsatira za placebo, motero lingaliro linachitika kuti lithetse msanga amaphunzira pambuyo pa zaka 3.3 m'malo mwa zaka zisanu.

Atorvastatin kwambiri adachepetsa kukula kwa zovuta zotsatirazi:

Panalibe kuchepa kwakukulu pakufa kwathunthu ndi mtima, ngakhale panali zochitika zabwino.

Pakufufuza kwapakati pa zotsatira za atorvastatin mwa odwala omwe ali ndi matenda a shuga 2 mellitus (CARDS) pazotsatira zakupha ndi zopanda pake zamatenda amtima, adawonetsedwa kuti chithandizo chamankhwala atorvastatin, kaya munthu ndi wodwala, zaka, kapena mulingo wapakati wa LDL-C, adachepetsa chiopsezo chokhala ndi zovuta zamtima zotsatirazi :

Pakufufuza kwakukonzanso kwa kusintha kwa coronary atherosulinosis ndi hypolipidemic tiba (REVersAL) ndi atorvastatin pa mlingo wa 80 mg mwa odwala omwe ali ndi matenda amitsempha yamagazi, tapezeka kuti kuchepa kwapakati pa voliyumu yonse ya atheroma (gawo lalikulu la chidziwitso) kuyambira pachiyambire kafukufukuyo panali 0.4%.

Intensive Cholesterol Reduction Programme (SPARCL) idapeza kuti atorvastatin pa mlingo wa 80 mg patsiku amachepetsa chiopsezo chobwereza kapena kusaphedwa kwa odwala omwe ali ndi mbiri ya kuwonongeka kapena kusakhalitsa kwa ischemic matenda opanda ischemic matenda a mtima ndi 15% poyerekeza ndi placebo. Nthawi yomweyo, chiopsezo cha zovuta zazikuluzikulu za mtima ndi njira zotsitsimutsira magazi zinachepetsedwa kwambiri. Kuchepetsa chiopsezo cha matenda amkati pamtima pa atorvastatin adawonedwa m'magulu onse kupatula okhawo omwe amaphatikiza odwala omwe ali ndi vuto loyambira kapena lozungulira hemorrhagic stroke (7 pagulu la atorvastatin motsutsana ndi 2 mu gulu la placebo).

Odwala omwe amathandizidwa ndi atorvastatin mankhwala pa mlingo wa 80 mg, kuchuluka kwa hemorrhagic kapena ischemic stroke (265 motsutsana 311) kapena IHD (123 motsutsana 204) kunali kochepa poyerekeza ndi gulu lolamulira.

Kupewa kwachiwiri kwa mtima wamavuto

Malinga ndi New Target Study (TNT), zotsatira za atorvastatin pamiyeso ya 80 mg patsiku ndi 10 mg patsiku pachiwopsezo chokhala ndi zovuta zamtima mwa odwala omwe ali ndi matenda amitsempha yamagetsi otsimikizika.

Atorvastatin pa mlingo wa 80 mg kwambiri adachepetsa kukula kwa zovuta zotsatirazi:

Pharmacokinetics

Atorvastatin imalowa mwachangu pambuyo pakukonzekera pakamwa, Cmax imatheka pambuyo pa maola 1-2. Mlingo wa mayamwidwe ndi kuchuluka kwa atorvastatin mu plasma yamagazi ukuwonjezeka molingana ndi mlingo. Mtheradi wa bioavailability wa atorvastatin ndi pafupifupi 14%, ndipo dongosolo la bioavailability la inhibitory zochita motsutsana ndi HMG-CoA reductase lili pafupifupi 30%. Kutsekeka kwachilengedwe kwachilengedwe kumachitika chifukwa cha kagayidwe kachakudya paminyewa ya m'mimba ndi / kapena pa "gawo loyambirira" kudzera m'chiwindi. Chakudya chimachepetsa kuchuluka kwake komanso kuchuluka kwa mayamwidwe ndi 25% ndi 9%, motsatana (monga zikuwonetsedwa ndi zotsatira za kutsimikiza kwa Cmax ndi AUC), Komabe, mulingo wa LDL-C mukamamwa atorvastatin pamimba yopanda kanthu komanso pakudya umachepa pafupifupi chimodzimodzi. Ngakhale kuti atamwa atorvastatin madzulo, milingo yake ya plasma ndiyotsika (Cmax ndi AUC ndi 30%) kuposa atatha kumwa m'mawa, kuchepa kwa LDL-C sikudalira nthawi yamasiku omwe mankhwalawa amwedwa.

Vd wamba wa atorvastatin ndi pafupifupi 381 malita. Kumangidwa kwa mapuloteni a atorvastatin kupita ku mapuloteni a plasma kuli pafupifupi 98%. Chiwerengero cha milingo ya atorvastatin m'magazi ofiira a magazi / madzi am'magazi ndi pafupifupi 0,25, i.e. atorvastatin simalowa m'magazi ofiira magazi.

Atorvastatin imapangidwa mwamphamvu kuti apange ortho- ndi para-hydroxylated derivatives ndi zinthu zingapo za beta-oxidation. In vitro, ortho- ndi para-hydroxylated metabolites imalepheretsa kusintha kwa HMG-CoA, kufananizidwa ndi atorvastatin. Ntchito zoletsa kutsutsana ndi HMG-CoA reductase ndi pafupifupi 70% chifukwa cha zochita zama metabolites. Kafukufuku wa in vitro akuwonetsa kuti CYP3A4 isoenzyme imachita mbali yofunika kwambiri pakukula kwa atorvastatin. Izi zikutsimikiziridwa ndikuwonjezereka kwa kuchuluka kwa atorvastatin m'madzi am'magazi a anthu pamene akutenga erythromycin, yomwe imalepheretsa iyi isoenzyme.

Kafukufuku wa in vitro awonetsanso kuti atorvastatin ndi choletsa chofooka cha CYP3A4 isoenzyme. Atorvastatin analibe zovuta zowonekera pamatenda a terfenadine m'magazi am'magazi, omwe amapangika makamaka ndi isoenzyme CYP3A4, motere, zotsatira zazikulu za atorvastatin pa pharmacokinetics zamagawo ena a isoenzyme CYP3A4 ndizosatheka.

Atorvastatin ndi ma metabolites ake amachotseredwa ndi bile pambuyo pa hepatic ndi / kapena metabolism yowonjezera (atorvastatin sakhala ndikuchitika mobwerezabwereza kwambiri). T1 / 2 ili pafupifupi maola 14, pomwe mphamvu yoletsa kukwiya kwa HMG-CoA reductase pafupifupi 70% imatsimikiziridwa ndi ntchito yozungulira metabolites ndipo imapitilira pafupifupi maola 20-30 chifukwa cha kupezeka kwawo. Pambuyo pakamwa, osachepera 2% ya mlingo wa atorvastatin wapezeka mu mkodzo.

Pharmacokinetics mu milandu yapadera yamankhwala

Kuchulukitsa kwa plasma kwa atorvastatin mwa okalamba (wazaka 65?) Ndiwokwera (Cmax ndi 40%, AUC pafupi 30%) kuposa kwa odwala achikulire. Panalibe kusiyana pakukhwimitsa chitetezo, kuchita bwino, kapena kukwaniritsa zolinga zamankhwala ochepetsa lipid mu okalamba poyerekeza ndi anthu ambiri.

Maphunziro a pharmacokinetics a mankhwalawa mu ana sanachitike.

Magulu a plasma a atorvastatin mwa akazi amasiyana (Cmax ndi 20% apamwamba, ndi AUC mwa 10% kutsika) kwa iwo omwe ali amuna. Komabe, kusiyana kwakukulu mwakuthupi kwa mankhwala a lipid metabolism mwa amuna ndi akazi sikunadziwike.

Kuwonongeka kwa impso sikukhudza kuchuluka kwa atorvastatin m'madzi a m'magazi kapena kukhudzana ndi metabolid ya lipid. Pankhani imeneyi, kusintha kwa odwala omwe ali ndi vuto laimpso sikofunikira.

Atorvastatin samachotsedwa pa hemodialysis chifukwa chomangirira mapuloteni a plasma.

Kuzungulira kwa Atorvastatin kumawonjezeka kwambiri (Cmax ndi AUC pafupi ndi 16 ndi 11 nthawi, motero) mwa odwala omwe ali ndi vuto la zakumwa zoledzeretsa (kalasi B pamulingo wa Mwana-Pugh).

Zisonyezero zogwiritsira ntchito mankhwala LIPRIMAR ®

• chachikulu hypercholesterolemia (heterozygous achibale komanso osakhala achibale hypercholesterolemia (mtundu IIa malinga ndi gulu la Fredrickson),
• kuphatikiza (kusakaniza) hyperlipidemia (mitundu IIa ndi IIb malinga ndi gulu la Fredrickson),
• dibetalipoproteinemia (mtundu wa III malinga ndi gulu la Fredrickson) (monga zakudya),
• mabanja amkati hypertriglyceridemia (mtundu IV malinga ndi gulu la Fredrickson), yogonjetsedwa ndi zakudya,
• homozygous achibale hypercholesterolemia osakwanira kudya mankhwala ndi njira zina sanali mankhwala
• kupewa kwakukulu kwa zovuta zamtima mu mtima mwa odwala osakhala ndi matenda am'matumbo, koma ndi zinthu zingapo zomwe zingayambitse kukula kwake - msinkhu woposa zaka 55, kusuta kwa chikonga, matenda oopsa, matenda ashuga, kutsika kwa HDL-C mu plasma, kuperewera kwa majini, etc. maola motsutsana ndi maziko a dyslipidemia,
• kupewa kwachiwiri kwamatenda amtima mwa odwala omwe ali ndi matenda amtima kuti achepetse chiwerengero cha anthu omwalira, matenda amitsempha yam'mimba, sitiroko, kuyambiranso kuchipatala kwa angina pectoris ndi kufunika kosinthanso.

Mlingo ndi makonzedwe

Asanayambe chithandizo ndi Liprimar, ayenera kuyesa kupeza mphamvu ya hypercholesterolemia mothandizidwa ndi zakudya, masewera olimbitsa thupi komanso kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri, komanso chithandizo cha matenda oyambitsidwa.

Popereka mankhwala, wodwalayo ayenera kulimbikitsa mtundu wa zakudya zomwe ayenera kutsatira pakumwa.

Mankhwala amatengedwa pakamwa nthawi iliyonse ya tsiku, mosasamala kanthu za kudya. Mlingo wa mankhwalawa umasiyana 10 mg mpaka 80 mg kamodzi patsiku, kusankha kwa mankhwalawa kuyenera kuchitika molingana ndi magawo oyamba a LDL-C, cholinga cha mankhwala ndi zotsatira zake. Mlingo waukulu kwambiri ndi 80 mg kamodzi patsiku.

Kumayambiriro kwa mankhwalawa komanso / kapena pakuwonjezeka kwa mlingo wa Liprimar, ndikofunikira kuyang'anitsitsa zomwe zili m'magazi a plasma masabata onse a 2-4 ndikusintha mlingo moyenerera.

Kwa hypercholesterolemia yoyamba komanso yophatikizika (yophatikiza) hyperlipidemia kwa odwala ambiri, mlingo wa Liprimar ndi 10 mg kamodzi patsiku. Zotsatira zakuchiritsika zimawonekera mkati mwa masabata awiri ndipo nthawi zambiri zimafika pakadutsa masabata anayi. Ndi chithandizo chakanthawi, zotsatira zake zimapitilira.

Ndi homozygous achibale hypercholesterolemia, mankhwala zotchulidwa mu 80 mg kamodzi patsiku. (kutsika kwa mulingo wa LDL-C ndi 18-45%).

Ngati vuto la chiwindi likulephera, mlingo wa Liprimar uyenera kuchepetsedwa motsogozedwa nthawi zonse ndi ntchito ya ACT ndi ALT.

Ntchito yaimpso yolakwika siyikhudzanso kuchuluka kwa atorvastatin m'madzi am'magazi kapena kuchepa kwa zomwe LDL-C ikugwiritsa ntchito Liprimar, motero, kusintha kwa mankhwalawa sikofunikira.

Mukamagwiritsa ntchito mankhwalawa odwala okalamba, panalibe kusiyana kwazotetezeka, kugwira ntchito bwino poyerekeza ndi kuchuluka kwa anthu, komanso kusintha kwa mankhwala sikofunikira.

Ngati ntchito yolumikizana ndi cyclosporine ndikofunikira, mlingo wa Liprimar® sayenera kupitirira 10 mg.

Malangizo othandiza kudziwa tanthauzo la mankhwalawa

A. Malangizo kuchokera ku National NCEP Cholesterol Education Program, USA

* Akatswiri ena amalimbikitsa kugwiritsa ntchito mankhwala ochepetsa mphamvu ya lipid omwe amachepetsa zomwe zili mu LDL-C ngati kusintha kwa moyo wawo sikungachititse kuti zinthu zake zichepe.

Zinthu zopangidwa ndi Rosuvastatin

"Rosuvastatin" ndi wothandizira m'badwo wachitatu omwe ali ndi vuto la kuchepetsa lipid. Kukonzekera komwe kumapangidwa pamaziko ake kumatha kusungunuka bwino m'magazi amadzimadzi. Zotsatira zawo zazikulu ndikuchepetsa kolesterol yathunthu ndi lipoprotein atherogenic. Mfundo ina yabwino, "Rosuvastatin" ilibe vuto lililonse m'maselo a chiwindi ndipo siziwononga minofu ya minofu. Chifukwa chake, ma statins omwe amachokera ku rosuvastatin satha kuyambitsa zovuta mu chiwindi, kulephera kwa transaminase, myositis, ndi myalgia.

Chachikulu pharmacological kanthu umalimbana kuphatikiza kaphatikizidwe ndikuwonjezera kuchulukana kwa zigawo za mafuta a atherogenic. Zotsatira zamankhwala zimachitika mwachangu kwambiri kuposa chithandizo cha Atorvastatin, zotsatira zoyambirira zimapezeka kumapeto kwa sabata loyamba, mphamvu yayitali imatha kuonedwa pakadutsa masabata atatu.

Mankhwala otsatirawa amachokera ku rosuvastatin:

• "Crestor" (kupanga Great Britain),
• Mertenil (wopangidwa ku Hungary),
• "Tevastor" (wopangidwa ku Israeli).

"Crestor" kapena "Liprimar" choti musankhe? Kukonzekera kuyenera kusankhidwa ndi adokotala.

Zogwiritsa ntchito Simvastatin

Chithandizo china chodziwika chotsitsa lipid ndi Simvastatin. Kutengera ndi ichi, mankhwala angapo apangidwa omwe amagwiritsidwa ntchito bwino pochiza matenda a atherosulinosis. Kuyesedwa kwachipatala kwa mankhwalawa, komwe kwachitika zaka zoposa zisanu ndikuphatikizira anthu opitilira 20,000, kwathandizira kunena kuti mankhwala opangidwa ndi simvastatin amachepetsa chiopsezo cha kugunda kwamtima ndi stroke chifukwa cha odwala omwe ali ndi vuto la mtima ndi mitsempha.

Analogs of Liprimar on simvastatin:

• Vasilip (wopangidwa ku Slovenia),
• Zokor (kupanga - Netherlands).

Chimodzi mwazinthu zodziwitsa zomwe zimakhudza kugulidwa kwa mankhwala enaake ndi mtengo wake. Izi zimagwiranso ntchito kwa mankhwala omwe amabwezeretsa zovuta zama metabolism yamafuta. Chithandizo cha matenda ngati amenewa chimapangidwa kwa miyezi yambiri, ndipo nthawi zina zaka. Mitengo yamankhwala ofanana mu zamankhwala imakhala yosiyana ndi makampani opanga mankhwala nthawi zina chifukwa cha mitengo yamitengo yosiyanasiyana yamakampani awa. Poika mankhwala ndi kusankha kwa mankhwalawa kuyenera kuchitika ndi adotolo, komabe, wodwalayo ali ndi kusankha kwa mankhwala kuchokera ku gulu limodzi lama pharmacological, lomwe limasiyana mu wopanga ndi mtengo.

Mankhwala onse omwe ali pamwambapa komanso akunja, omwe amalowa mmalo mwa Liprimar, adutsa mayeso azachipatala ndipo adzipanga okha ngati othandizira omwe amachititsa kuti mafuta azikhala ndi mafuta. Zabwino mwa njira yochepetsera cholesterol zimawonedwa mu 89% ya odwala mwezi woyamba wa chithandizo.

Ndemanga za Liprimar ndizabwino. Mankhwala amachepetsa mafuta m'thupi, amachepetsa chiopsezo cha matenda a mtima. Mwa zinthu zoyipa - mtengo wokwera ndi zoyipa. Za fanizo ndi ma jenito, ambiri monga Atoris. Zimagwira chimodzimodzi kwa Liprimaru, kwenikweni sizimayambitsa mayendedwe olakwika a thupi.

Ndemanga zimatsimikizira kuti pakati pazofananira zotsika mtengo, Russian Liptonorm ndiyomwe imakonda. Zowona, machitidwe ake ndi oyipa kuposa a Liprimar.

Simvastatin yochokera lypimar analogs

Mankhwala ena a hypolipidemic ndi simvastatin. Kugwiritsidwa ntchito ngati mankhwala kwa nthawi yayitali, amatanthauza m'badwo wakale wama statins. Kafukufuku wachipatala atsimikizira kugwira ntchito kwake popewa matenda amtima ndi mikwingwirima mwa odwala omwe ali ndi matenda amtima.

Mankhwala otchuka kwambiri:

• Vasilip (Krka, Slovenia). Mapiritsi 28 a 10 mg angagulidwe kwa ma ruble 350.,
• Zokor (MSD Madawa, Netherlands). Mapiritsi 28 a 10 mg amatenga 380 ma ruble.

Malangizo posankha mankhwalawa

Dokotala wanu ayenera kukupatsani mankhwala osankha omwe ali oyenera. Koma popeza mtengo wa mankhwalawa umasiyanasiyana ndipo nthawi zina umakhala wofunikira kwambiri, wodwalayo amatha kusintha pawokha posankha mankhwala, powona gulu la mankhwalawa lomwe mankhwalawo ali: atorvastatin, rosuvastatin kapena simvastatin.

Ndiko kuti, ngati mwayika mankhwala piritsi la atorvastatin, muthanso kusankha analog yochokera pazinthu izi.

Liprimar, ndemanga zake zomwe ndizabwino kwambiri kuchokera kumbali ya odwala komanso kumbali ya madokotala, ndiye chisankho chabwino kwambiri pakuchepetsa kwamankhwala mu cholesterol "yoyipa" m'magazi, chifukwa ichi ndi mankhwala oyambira komanso otsimikiziridwa.

Dalirani mankhwala omwe ayesedwa ndikuwatsimikizira kuti agwira ntchito. Mukamalandira ndalama zotere, pafupifupi 90% ya odwala amachepetsa mafuta m'thupi kale m'masabata atatu oyamba kutsata.

Makhalidwe a Liprimar

Ichi ndi mankhwala ochepetsa lipid, omwe amaphatikizira gawo logwira ntchito la atorvastatin. Kutulutsa mawonekedwe - mapiritsi. Mankhwala oterewa amadziwika ndi lipid-kuchepetsa komanso hypocholesterolemic katundu. Mothandizidwa ndi chinthu chachikulu:

• kuchuluka kwa lipoproteins otsika m'magazi kumachepa,
• kuchuluka kwa triglycerides kumachepa,
• kuchuluka kwa osachulukitsa lipoproteins kumawonjezeka.

Mankhwala amachepetsa cholesterol ndi kapangidwe kake m'chiwindi. Izi zimakuthandizani kuti mupeze mankhwala a mitundu yosiyanasiyana ya dyslipidemia, cholowa ndi matenda a hypercholesterolemia, ndi zina. Kuchita kwake kumawoneka ndi mawonekedwe a homozygous a hypercholesterolemia. Kuphatikiza apo, chida ichi chimagwiritsidwa ntchito pochiza matenda a angina pectoris ndi zovuta zina zamkati pamtima, potero kuchepetsa chiopsezo cha zovuta.

Zisonyezero zogwiritsidwa ntchito:

• hypercholesterolemia yoyamba,
• endo native banja hypertriglyceridemia,
• dysbetalipoproteinemia,
• Hyperlipidemia yosakanikirana.

Monga njira yolepheretsa matenda a mtima dongosolo:

• odwala omwe ali pachiwopsezo chotenga matenda a mtima ndi mtima.
• ndi angina pectoris, kupewa kukula kwa zilonda zam'mimba, stroko, mtima.

Contraindations akuphatikiza:

• mimba
• nthawi yoyamwitsa,
• matenda a chiwindi
• Hypersensitivity pazogulitsa,
• glucose-galactose malabsorption,
• kobadwa nako kwa lactase,
• gwiritsani ntchito fusidic acid,
• wazaka 18.

Nthawi zambiri, kutenga Liprimar kumapangitsa kuti pakhale kusintha kwamphamvu kwa thupi komwe kumachitika modekha ndipo kumadutsa mwachangu:

• mutu, chizungulire, kusokonezeka kukumbukira ndi kulawa, kufooka, paresthesia,
• kukhumudwa
• mawonekedwe a "chophimba" pamaso, mawonekedwe opuwala,
• tinnitus, osowa kwambiri - kutaya kwa makutu,
• magazi ochokera pamphuno, zilonda zapakhosi,
• kutsekula m'mimba, mseru, kugaya chimbudzi, kumatulutsa, kusokoneza m'mimba, kutupa kwa kapamba, kumenyera,
• hepatitis, cholestasis, kulephera kwa impso,
• khola, zotupa, pakhungu pakhungu, uritisaria, matenda a Lyell, angioedema,
• kupweteka kwa minofu ndi kumbuyo, kutupa kolumikizana, kukokana kwa minofu, kupweteka kwapakati, kupweteka kwa khosi, myopathy,
• kusabala
• thupi lawo siligwirizana, anaphylactic mantha,
• hyperglycemia, anorexia, kulemera, hypoglycemia, matenda a shuga,
• thrombocytopenia
• nasopharyngitis,
• kutentha thupi, kutopa, kutupa, kupweteka pachifuwa.

Kugwiritsa ntchito Liprimar kumabweretsa mawonekedwe a: kupweteka mutu, chizungulire, kusokonezeka kwa kukumbukira ndi kumva zamkati, hypesthesia, paresthesia.

Asanapange mankhwala ndi mankhwalawa, adokotala amayesa kuchuluka kwa cholesterol m'magazi, kenako amakupatsani ntchito zolimbitsa thupi ndi zakudya. The achire zotsatira kumwa mankhwalawa pambuyo 2 milungu. Ngati chiwopsezo cha KFK chaposa nthawi 10, chithandizo ndi Liprimar sichitha.

Kodi pali kusiyana kotani?

Wopanga Atorvastatin ndi Atoll LLC (Russia), Liprimara - PFIZER MANUFACTURING DEUTSCHLAND GmbH (Germany). Mapiritsi a Atorvastatin amakhala ndi chipolopolo choteteza, chomwe chimachepetsa mwayi wosagwirizana ndi m'mimba. Mapiritsi a Liprimar alibe chipolopolo choterocho, motero sakhala otetezeka kwambiri.

Ndemanga za Odwala

Tamara, wazaka 55, ku Moscow: "Chaka chapitacho kuyezetsa magazi kunachitika, ndipo kuyezetsa kunawonetsa kuti ndinali ndi cholesterol yayikulu m'magazi anga. Cardiologist adayikira Liprimar. Adalekerera njira yoperekera chithandizo, ngakhale kuti amawopa kuti pakachitika zovuta zina mthupi. Pambuyo pa miyezi 6 ndidapambana mayeso achiwiri, omwe adawonetsa kuti cholesterol ndiyabwino. "

Dmitry, wazaka 64, Tver: “Ndili ndi matenda ashuga komanso matenda a mtima. Dokotala adalimbikitsa kolesterol yochepetsa, pomwe amafunika kumwa mankhwala Atorvastatin. Ndinkamwa piritsi limodzi 1 nthawi patsiku. Pakadatha milungu 4 adandiyesa - cholesterol ndiyabwino. ”

Mawonekedwe a mankhwala Liprimar

Ndi mankhwala, achire kwambiri omwe ali kutsitsa magazi ndi mafuta m'thupi. Ndi iyo, kufalikira kwa mtima kumachitika, mkhalidwe wamatumbo umayenda bwino, ndipo chiopsezo chotenga matenda opha amachepetsa.

Zizindikiro zotsatirazi zomwe zikugwiritsidwa ntchito ndizodziwika bwino:

• Kuchuluka kwachilendo kwa cholesterol.
• Mafuta ambiri.
• Kuvulala kwamtundu wa lipid metabolism.
• Kuchulukitsa kwa triglyceride.
• Zizindikiro za matenda a mtima.
• Kupewa matenda a mtima.

1. Hypersensitivity kumagawo.
2. Kulephera kwa chiwindi.
3. Hepatitis ya pachimake siteji.
4. Diso lamaso.
5. Kuchulukitsa kwa ntchito ya othandizira.
6. Mimba komanso nthawi yoyamwitsa.

Nthawi zambiri, mankhwalawa amaloledwa popanda kuyambitsa mavuto. Koma nthawi zina, zosagwirizana ndi zomwe zimachitika m'matumbo, manjenje ndi minyewa ya mafupa, ziwongo zimatha kuchitika.
Pazitali kwambiri ndende pambuyo kukhazikitsa kumachitika maola angapo. Chosakaniza chophatikizacho ndi mchere wa calcium. Zowonjezera zimaphatikizapo calcium carbonate, mkaka wokhala ndi mkaka, zowonjezera E468, mapadi, lactose ndi zina.

Zofanana ndalamazi

Mankhwala omwe afunsidwa ndi kufanana kwathunthu kwa wina ndi mnzake. Onsewa amavomerezedwa ndi odwala ndipo amathandiza kwambiri. Amaphatikizanso zomwe zimagwira chimodzimodzi, motero ali ndi zofanana zochizira. Onsewa akupezeka piritsi. Alinso ndi malingaliro ofanana kuti agwiritse ntchito, contraindication, mavuto, mfundo yofunikira.

Kuyerekeza, kusiyanitsa, zomwe ndi ziti ndikofunika kusankha

Mankhwalawa alibe kusiyana kwakukulu, chifukwa amatha kuthandizana, kale Kugwirizanitsa izi ndi adotolo opezekapo.

Chimodzi mwazosiyana ndi dziko lomwe mudachokera. Liprimar ndi mankhwala oyamba opangidwa ku America, ndipo Atorvastatin ndi woweta. Pankhaniyi, ali ndi ndalama zosiyana. Mtengo wazoyambira ndi wokwera mtengo nthawi 7-8 ndipo ndi 700-2300 ma ruble, pafupifupi mtengo wa atorvastatin 100-600 ma ruble. Chifukwa chake, pankhaniyi, mankhwala apamba amapambana.

Ngakhale kuti ali ndi zomwe zimagwiritsidwa ntchito momwemonso, Liprimar imawonedwabe ngati yothandiza kwambiri, chifukwa ndi mankhwala oyambira. Analogue yakunyumba mu izi ndi yotsika pang'ono kwa iye ndipo imakhala ndi zotsatirapo zoyipa kwambiri mthupi, monga zikuwonetsedwa ndi kuwunika kwa odwala. Kuphatikiza apo, Liprimar imagwiritsidwa ntchito mosamala ndi ana. Ndi mankhwala okhawo omwe amachepetsa mafuta a cholesterol omwe angagwiritsidwe ntchito pochiritsa ana azaka zisanu ndi zitatu. Mosiyana ndi Atorvastatin, sizikhudza kukula kwa thupi ndi njira yakutha kwa ana.

Zitha kugwiritsidwa ntchito pochiza odwala matenda a shuga a mtundu woyamba kapena wachiwiri. Koma musaiwale kuti gawo lawo lomwe limagwira limatha kusintha magazi, chifukwa chake chithandizo chikuyenera kuchitika moyang'aniridwa ndi dokotala. Chifukwa chakuti mapiritsi a Atorvastatin amakhala atakulungidwa ndi filimu, chida choterechi chidzakondedwa kwambiri ndi anthu omwe ali ndi matenda awa. Popeza chipolopolo chimachepetsa chiopsezo cha zovuta zina.

Njira yamachitidwe

Kuphatikiza pa cholesterol, kuphatikiza mafuta ochulukirapo a protein omwe amakhala ndi otsika kachulukidwe (LDL) kumakhalanso koopsa ku mtima. Amakhazikika pamakoma amitsempha yamagazi, ndikupanga malo otchedwa cholesterol plaques. Zotsatira zake, atherosulinosis imayamba - matenda omwe mabowo amitsempha amachepa, makoma awo amawonongeka. Vutoli limakhala ndi zotupa (mikwingwirima), motero ndikofunikira kuwongolera kuchuluka kwa cholesterol "yoyipa".

Atorvastatin onse mankhwala pambuyo makonzedwe amalowa m'magazi ndi chiwindi maselo. Poyamba, amangowononga mafuta oyipa. Ndipo m'chiwindi, komwe amapanga mafuta a cholesterol, mankhwalawo amaphatikizidwa ndikuchita izi ndikuchepetsa. Atorvastatin ndi Liprimar ziyenera kutengedwa milandu pomwe zakudya ndi masewera sizothandiza (monga chikhalidwe cha hypercholesterolemia).

Atorvastatin ndi Liprimar amapangidwira mawonekedwe amodzi:

• cholowa cholowa chamitundu mitundu, chosagwiritsidwa ntchito ndi chithandizo cha zakudya komanso maphunziro akuthupi,
• vuto pambuyo vuto la mtima (necrosis ya gawo la minofu ya mtima chifukwa cha kusokonezeka kwazizungulira),
• matenda a mtima - kuwonongeka kwa minofu yake komanso kusokonekera chifukwa cha kuchepa kwa magazi,
• angina pectoris ndi mtundu wamatenda am'mbuyomu omwe amakhala ndi kupweteka kwambiri,
• matenda ashuga
• kuthamanga kwa magazi (matenda oopsa),
• atherosulinosis.

Tulutsani mafomu ndi mtengo

Atorvastatin wopanga zoweta amagulitsidwa muma pharmacies. Mankhwalawa amapangidwa ndi makampani angapo azamankhwala, omwe amafotokozera mitengo yake yambiri. Mtengowo umakhudzidwanso ndi kuchuluka kwa mapiritsi omwe ali mgululi komanso kuchuluka kwa zomwe zimagwira:

• 10 mg mu 30, 60 ndi 90 ma PC. mu paketi - 141, 240 ndi 486 ma ruble. motero
• 20 mg mu 30, 60 ndi 90 ma PC. - 124, 268 ndi 755 rubles,
• 40 mg, 30 ma PC. - kuyambira 249 mpaka 442 rubles.

Liprimar ndi piritsi loyimbira lokhazikika la kampani yaku America Pfizer. Mtengo wa mankhwalawa umapangidwa molingana ndi kuchuluka kwake ndi kuchuluka kwake:

• 10 mg, 30 kapena 100 zidutswa mu paketi - 737 ndi 1747 rubles.,
• 20 mg, 30 kapena 100 ma PC. - 1056 ndi 2537 ma ruble,
• 40 mg, mapiritsi 30 - ma ruble 1110.,
• 80 mg, mapiritsi 30 - 1233 ma ruble.