Mankhwala ASK-Cardio: malangizo ntchito

Mankhwala FUNSANI - Ndi mankhwala a antiplatelet omwe amalepheretsa kuphatikiza kwa maselo ambiri, komanso ali ndi antipyretic, analgesic komanso anti-kutupa. Aggregation imaletsa ngakhale mutagwiritsa ntchito mankhwala ochepa, zotsatira zake zimapitirira kwa masiku angapo mutamwa kamodzi. Mapiritsi okhala ndi zotupa za interic ndi mawonekedwe amtundu wa mankhwala omwe samasokoneza m'mimba, motero ngozi yolumikizana mwachindunji ya acetylsalicylic acid ndi mucosa wa m'mimba ndipo kuwonongeka kwake kumachepetsedwa. Kugawikana kwa piritsi ndi kutulutsidwa kwa chinthu chogwira ntchito kumachitika pokhapokha mu duodenum.

Zisonyezero zogwiritsidwa ntchito:
Mankhwala FUNSANI Kuchepetsa chiopsezo:
- Imfa odwala omwe akuwoneka kuti ali ndi vuto lalikulu la mtima,
- Imfa mwa odwala pambuyo poyambitsa matenda amiseche,
- osakhalitsa akuwukira (TIA) komanso kuwonongeka kwa odwala a TIA,
- kuchepa kwa thupi ndi imfa yokhazikika komanso yosakhazikika ya angina pectoris.
Mankhwala FUNSANI popewa:
- thrombosis ndi embolism pambuyo opaleshoni ya mtima (percutaneousumum catheter angioplasty (PTCA), carotid endarterectomy, coronary artery bypass grafting (CABG), arteriovenous shunting),
- mitsempha yakuya kwambiri ndi mapapo am'mimba pambuyo pakulimbitsa kwa nthawi yayitali
- kulowetsedwa kwa mtima mwa odwala omwe ali ndi chiopsezo chotenga matenda a mtima (shuga mellitus, otsogola oopsa) komanso anthu omwe ali ndi chiopsezo cha matenda amtima (hyperlipidemia, kunenepa kwambiri, kusuta, kukalamba, ndi zina zambiri).
Mankhwala FUNSANI kupewa yachiwiri ya sitiroko.

Njira yogwiritsira ntchito:
Akuluakulu nthawi zambiri amapatsidwa mapiritsi 1-2 a 75 mg kapena piritsi limodzi la 150 mg patsiku panthawi yakudya kapena itatha.

Mapiritsi FUNSANI Amayenera kumeza lonse ndi madzi pang'ono.
Ndi infrction yaposachedwa ya myocardial kapena kwa odwala omwe ali ndi vuto la kulowetsedwa kwa myocardial: njira yoyamba ya saturating ndi 225-300 mg wa acetylsalicylic acid 1 nthawi patsiku kuti akwaniritse kukakamiza kosavuta kwa kupatsidwa zinthu za m'magazi. Mlingo wa 300 mg patsiku ungagwiritsidwe ntchito kwakanthawi kochepa malinga ndi zochizira.
Mapiritsi otsekemera a kuyamwa mwachangu.

Zotsatira zoyipa:
Kuchokera m'mimba thirakiti, dyspepsia, kupweteka kwam'mimba ndi kupweteka kwam'mimba zimayang'aniridwa, nthawi zina - kutupa kwam'mimba, mawonekedwe amtundu wa zilonda zam'mimba komanso zotupa zam'mimba, zomwe nthawi zina zimatha kutulutsa m'mimba komanso kufalikira kwam'mimba. zizindikiro zasayansi.
Chifukwa cha antiplatelet momwe mumaphatikizira, acetylsalicylic acid imatha kuwonjezera ngozi. Mitsempha yamagazi monga ma hemorrhages otupa, hematomas, magazi ochokera m'matumbo, mphuno, magazi ochokera m'matumbo, kawirikawiri kapena kawirikawiri, magazi otupa monga zotupa zam'mimba, zotupa zam'mimba (makamaka odwala omwe ali ndi vuto losagwirizana ndi magazi) komanso / kapena munthawi yomweyo. kugwiritsa ntchito anti-he hetaticatic agents, nthawi zina, zitha kukhala zowopsa m'moyo. Kuchepa kwa m'mimba kumatha kuyambitsa magazi m'thupi komanso kuchepa kwa magazi m'thupi (kuchepa kwa kuchepa kwa magazi m'thupi) (chifukwa cha zomwe zimatchedwa latent microbleeding) ndi mawonetsedwe ofanana a ma laboratory ndi zizindikiro zamankhwala, monga asthenia, pallor pakhungu, hypoperfusion.
Odwala omwe ali ndi hypersensitivity ya salicylates, khungu lawo siligwirizana, kuphatikizapo zizindikiro monga totupa, urticaria, edema, komanso kuyabwa. Odwala bronchial mphumu, kuchuluka kwa bronchospasm n`zotheka, thupi lawo siligwirizana kuchokera wofatsa mpaka zolimbitsa amakhudza khungu, kupuma thirakiti, m'mimba thirakiti ndi mtima dongosolo.

Zochitika zingapo, kuphatikizapo mantha a anaphylactic, sizinawoneke kwambiri. Pafupipafupi, kufooka kwa chiwindi kwapang'onopang'ono komanso kuchuluka kwa chiwindi transaminases.
Chizungulire ndi tinnitus zinaonedwa, zomwe zingasonyeze bongo.

Zoyipa:
Contraindication kugwiritsa ntchito mankhwalawa FUNSANI ndi:
- Hypersensitivity ku acetylsalicylic acid, masicylylates ena kapena chinthu chilichonse cha mankhwala.
- Matenda amphumu oyambitsidwa ndi mbiri ya salicylates kapena NSAIDs.
- Zilonda zam'mimba zopweteka.
- hemorrhagic diathesis.
- Kulephera kwapakati.
- Kulephera kwa chiwindi.
- Kulephera kwamtima.
- Kuphatikiza ndi methotrexate pa mlingo wa 15 mg / sabata kapena kupitilira.

Mimba
Mankhwala FUNSANI itha kugwiritsidwa ntchito pa nthawi ya mimba pokhapokha ngati mankhwala ena sangathe.
Kugwiritsa ntchito ma salicylates mu trimester yoyamba ya kutenga pakati pa maphunziro ena obwezeretsanso omwe akuphatikizidwa ndi chiwopsezo chowonjezeka cha kusokonezeka kwatsopano (palatoschisis (cleft palate), zolakwika zamtima). Komabe, pogwiritsa ntchito mankhwalawa kwa nthawi yayitali muyezo wa mankhwala ochulukirapo 150 mg / tsiku, izi zidawoneka zochepa: chifukwa cha kafukufuku yemwe anachitika pa mabanja 32,000 a amayi, panalibe kuyanjana pakati pa kugwiritsa ntchito acetylsalicylic acid ndi kuchuluka kwa zolakwika zobadwa nazo.
Ma salicylates amatha kugwiritsidwa ntchito mu gawo loyambirira komanso lachiwiri la mimba pokhapokha pofufuza kuwopsa / phindu. Malinga ndi kuyerekezera koyambirira, kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, ndikofunika kuti asamamwe acetylsalicylic acid mu mlingo wopitirira 150 mg / tsiku.
Mu III trimester yokhala ndi pakati, kutenga kuchuluka kwa salicylates (kupitilira 300 mg / tsiku) kumatha kupangitsa kuti kubereka kunamize komanso kufooketsa mgwirizano pakubala, komanso kungayambitse vuto la mtima (kutsekedwa koyambirira kwa ductus arteriosus) mwa ana.
Kugwiritsa ntchito acetylsalicylic acid mu milingo yayikulu posachedwa kubadwa kungayambitse magazi mu intracranial, makamaka kwa ana akhanda.

Chifukwa chake, kupatula pazochitika zapadera zomwe zimafotokozedwa ndi zowunika zamtima kapena zowonjezera zovuta pazochitika zina zowunikira, kugwiritsa ntchito acetylsalicylic acid panthawi yomaliza yam'mimba imatsutsana.
Acetylsalicylic acid ndi ma metabolites ang'onoang'ono amachotsedwa mkaka wa m'mawere azimayi anyama. Mpaka pano, ndi kugwiritsa ntchito kwakanthawi kwama salicylates ndi amayi, kuyambika kwa zotsatira zosayenerera mu ana oyamwitsa sikunakhazikitsidwe, monga lamulo, palibe chifukwa chosiya kuyamwitsa. Komabe, ngati ntchito yayitali ya acetylsalicylic acid yatha, kuyamwitsa kuyenera kuyimitsidwa.

Mogwirizana ndi mankhwala ena:
Kugwiritsa ntchito acetylsalicylic acid munthawi yomweyo ndi methotrexate mu Mlingo wa 15 mg / sabata ndi zina zambiri zotsutsana chifukwa cha kuchuluka kwa hematological kawopsedwe ka methotrexate (kuchepa kwa impso kuchulukitsa kwa methotrexate ndi othandizira-kutulutsa komanso kusungunuka kwa methotrexate ndi ma salicylates chifukwa cha mapuloteni a plasma).
Kuphatikiza komwe kumagwiritsidwa ntchito mosamala:
- ntchito ndi methotrexate mu Mlingo wochepera 15 mg / sabata kumawonjezera hematological kawopsedwe wa methotrexate (kuchepa kwa impso chilolezo cha methotrexate ndi anti-yotupa kothandizirana ndikuthamangitsidwa kwa methotrexate ndi salicylates ogwirizana ndi mapuloteni a plasma).
- Kugwiritsa ntchito ibuprofen munthawi yomweyo kumalepheretsa kuponderezana kosasinthika kwa maplatelet ndi acetylsalicylic acid. Mankhwala a Ibuprofen kwa odwala omwe ali pachiwopsezo cha matenda amtima angachepetse mtima wake chifukwa cha acetylsalicylic acid.
- munthawi yomweyo kugwiritsa ntchito mankhwalawa ndi ma anticoagulants, chiopsezo chotulutsa magazi chimakulanso. Ndi munthawi yomweyo kugwiritsa ntchito milingo yambiri ya salicylates omwe ali ndi NSAIDs (chifukwa chosinthira mphamvu), chiwopsezo cha zilonda zam'mimba komanso magazi am'mimba amachulukanso.
- Kugwiritsa ntchito pamodzi ndi uricosuric othandizira, monga benzobromaron, probenecid, kumachepetsa mphamvu ya uric acid excretion (chifukwa cha mpikisano wothira uric acid ndi renal tubules).
- munthawi yomweyo kugwiritsa ntchito digoxin, kugwiritsidwa ntchito kwa plasma yamwazi kumawonjezeka chifukwa cha kuchepa kwa impso.
- ndi munthawi yomweyo kugwiritsa ntchito mankhwala ambiri a acetylsalicylic acid komanso mankhwala amkamwa antidiabetic kuchokera ku gulu la sulfonylurea kapena insulin, zotulukapo za hypoglycemic zimatheka chifukwa cha hypoglycemic zotsatira za acetylsalicylic acid komanso kusamutsidwa kwa sulfonylurea komwe kumalumikizana ndi mapuloteni a plasma.
- okodzetsa osakaniza ndi michere yambiri ya acetylsalicylic acid amachepetsa kusefera chifukwa cha kuchepa kwa kaphatikizidwe ka prostaglandin mu impso.
- zokhudza zonse glucocorticosteroids (kupatula hydrocortisone) wogwiritsidwa ntchito monga mankhwala othandizira matenda a Addison panthawi ya chithandizo cha mankhwala a corticosteroids amachepetsa kuchuluka kwa masilicylates m'magazi ndikuwonjezera chiopsezo cha mankhwala osokoneza bongo atatha kulandira chithandizo.

Mukamagwiritsidwa ntchito ndi corticosteroids, chiopsezo chotenga magazi m'mimba chimawonjezeka.
- kusankha serotonin kubwezeretsanso zoletsa: kuchuluka chiopsezo cha magazi kuchokera chapamwamba m'mimba thirakiti chifukwa cha mwayi wa synergistic.
- ACE inhibitors (ACE) kuphatikiza waukulu Mlingo wa acetylsalicylic acid amachititsa kuchepa kwa kusefera chifukwa cha kuletsa kwa vasodilator prostaglandins komanso kuchepa kwa mphamvu ya antihypertensive.
- yogwiritsidwa ntchito nthawi yomweyo ndi valproic acid, acetylsalicylic acid imayichotsa kumagwirizana ndi mapuloteni a plasma, ndikuwonjezera kawopsedwe kowopsa.
Mowa wa Ethyl umathandizira kuwonongeka kwa mucous membrane wa m'mimba ndipo umakulitsa nthawi yotaya magazi chifukwa cha synergism ya acetylsalicylic acid ndi mowa.

Bongo
Mankhwala osokoneza bongo ochulukirapo amatha chifukwa cha kuledzera kwa nthawi yayitali, komanso kuledzera kwambiri, komwe kumabweretsa chiopsezo (bongo), komanso komwe kungayambike, mwachitsanzo, kugwiritsa ntchito ana mwangozi kapena mankhwala osayembekezereka.
Zizindikiro zoyambirira za kuledzera ndi acetylsalicylic acid ndi chizungulire, mseru, kusanza, tinnitus ndi kupuma mwachangu, kusasamala. Zizindikiro zina zinawonedwanso: kusamva kwa makutu, kuwonongeka kwa mutu, kupweteka mutu, kutuluka thukuta kwambiri, kuyendetsa galimoto, kugona komanso kukomoka, kukokana, matenda oopsa, chisokonezo. Poizoni wa salicylate amatha kubisika, chifukwa zizindikiro ndi mawonekedwe ake sizikudziwika.
Ngati mukumwa mlingo waukulu wa mankhwalawo kuposa womwe mwalimbikitsa, muyenera kufunsa dokotala, ndipo ngati mukumupatsa poyizoni muyenera kupita kuchipatala.
Mankhwala osokoneza bongo mwa odwala okalamba komanso mwa ana aang'ono (kutenga zazikulu kuposa momwe analimbikitsira kapena poyizoni mwangozi) amafunikira chisamaliro chapadera, chifukwa m'magulu a odwala izi zimatha kupha.
Mukuledzera kwambiri, acid-base usawa komanso madzi osankhidwa mwa electrolyte amasokonezeka (metabolic acidosis ndi madzi osowa madzi m'thupi).
Palibe mankhwala enieni.

Malo osungirako:
Sungani pamalo otetezedwa ku chinyezi ndi kuwala pa kutentha kosaposa 25 ° C.
Pewani kufikira ana.

Kutulutsa Fomu:
ASA - mapiritsi okhala ndi enteric, 75 mg ndi 150 mg.
Kuyika: 10 kapena 15 mapiritsi a matuza. Zitatu, zisanu kapena zisanu ndi chimodzi matuza a mapiritsi 10 aliwonse, limodzi ndi malangizo ogwiritsira ntchito paketi yamakhadi.
Matumba asanu ndi limodzi a mapiritsi 15 aliwonse, pamodzi ndi malangizo ogwiritsira ntchito paketi yamakhadibhodi.

Zopangidwa:
Piritsi 1FUNSANI Muli yogwira mankhwala: acetylsalicylic acid - 75 mg kapena 150 mg.
Omwe amachokera: wowuma chimanga, crospovidone (polyplasdone XL-10), talc, cellcrystalline cellulose.
Mapangidwe a Shell: Adred Prefavor (hydroxypropyl methylcellulose, kopovidone, polydextrose, propylene glycol, kati chain triglycerides, titanium dioxide, yellow iron oxide), Advantia Performance® (methaconic acid-ethyl acrylate Copolymer, talc, titanium dioxide, triethyl yellowite , ofiira ofiira E 129).

Chosankha:
Mankhwala FUNSANI ntchito mosamala ngati: hypersensitivity kwa analgesic, odana ndi yotupa, mankhwala osokoneza bongo, komanso pamaso pa chifuwa zinthu zina, zilonda zam'mimba, kuphatikizapo mbiri ya matenda obwereza kapena obwereza m'mimba, kugwiritsa ntchito pamodzi kwa anticoagulants, kapena chiwindi.
Ngati mukugwiritsa ntchito mankhwala kwa nthawi yayitali, wodwalayo ayenera kufunsa dokotala musanamwe ibuprofen.
Odwala omwe ali ndi vuto losakanikirana, kuphatikizapo mphumu ya bronchial, chifuwa chachikulu, kuchepa kwa khungu, kutupa kwa mucous nembanemba, komanso kuphatikizira matenda opumira komanso kwa odwala omwe ali ndi hypersensitivity ku NSAIDs omwe amathandizidwa ndi acetylsalicylic acid mwina kukula kwa bronchospasm kapena kuukira kwa mphumu ya bronchial. Pochita opaleshoni (kuphatikizapo mano), kugwiritsa ntchito mankhwala okhala ndi acetylsalicylic acid kumatha kukulitsa magazi. Ndi milingo yaying'ono ya acetylsalicylic acid, uric acid excretion ikhoza kuchepetsedwa. Izi zimatha kuyambitsa gout kwa odwala omwe amachepetsa uric acid excretion.
Mankhwalawa acetylsalicylic acid sayenera kumwa mowa, chifukwa chowonjezera kuwonongeka kwa mucous nembanemba am'mimba thirakiti.
Osagwiritsa ntchito mankhwala okhala ndi acetylsalicylic acid wa ana omwe ali ndi matenda opatsirana pachimake (ARVI), omwe amatsagana kapena osatsagana ndi kuwonjezeka kwa kutentha kwa thupi. Kwa matenda ena amavairasi, makamaka fuluwenza A, fuluwenza B ndi nthomba, pali chiopsezo chotenga matenda a Reye, omwe ndi matenda osowa kwambiri koma owopsa omwe amafuna chithandizo chamankhwala mwachangu. Chiwopsezocho chitha kupitilizidwa ngati acetylsalicylic acid amagwiritsidwa ntchito ngati mankhwala ophatikizira, koma chiyanjano sichinatsimikizidwe pankhaniyi. Ngati izi zimaperekedwa limodzi ndi kusanza kwanthawi yayitali, ichi chikhoza kukhala chizindikiro cha matenda a Reye. Poganizira zifukwa zili pamwambazi, ana osaposa zaka 16 amalephera kugwiritsa ntchito mankhwalawa popanda ziwonetsero zapadera (matenda a Kawasaki).
Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu
ASA sikukhudza kuyendetsa magalimoto ndi kayendedwe kazinthu.

Kutulutsa mawonekedwe ndi kapangidwe kake

ASK-Cardio imapezeka mu mapiritsi okhala ndi enteric: biconvex, yozungulira, yoyera (zidutswa 10 pa chithuza, mu bokosi la makatoni a 1, 2, 3, 5, 6 kapena 10, 30, 50, 60 kapena Mapiritsi 100 ali mumatini a polima, pamatoni a makatoni 1 angathe).

Piritsi 1:

yogwira mankhwala: acetylsalicylic acid (ASA) - 100 mg,
othandizira zigawo zikuluzikulu: wowuma wa mbatata, stearic acid, lactose monohydrate, talc, polyvinylpyrrolidone,
zokutira enteric: macrogol 6000, titanium dioxide, talc, wokopera wa methaconic acid ndi ethacrylate.

Zizindikiro zogwiritsidwa ntchito

angina wosakhazikika,
kupewa ngozi zaposachedwa kwambiri.
kupewa kwa thromboembolism kwa chotupa cha m'mapapo ndi nthambi zake, komanso vein thrombosis (mwachitsanzo, ndi kusakhazikika kwa nthawi yayitali chifukwa chakuchita opaleshoni yayikulu),
kupewa matenda opha ziwalo (kuphatikizapo odwala omwe ali ndi matenda osakhalitsa a cerebrovascular matenda),
kupewa kupewa pachimake myocardial kulowetsedwa vuto la chimodzi kapena zingapo zoopsa (ochepa matenda oopsa, matenda a shuga, kunenepa kwambiri, hyperlipidemia, ukalamba, kusuta fodya), kupewa kulowetsedwa kwa myocardial,
kupewa thromboembolism pambuyo zowononga ndi opaleshoni ya mtima (mwachitsanzo arteriovenous bypass, corteryary artery bypass grafting, carotid artery angioplasty, carotid artery endarterectomy).

Contraindication

kulephera kwambiri kwa chiwindi
kulephera kwambiri kwaimpso
hemorrhagic diathesis (von Willebrand matenda, hypoproteinemia, thrombocytopenic purpura, hemophilia, telangiectasia, thrombocytopenia),
matenda olephera a mtima a III-IV ogwira ntchito,
m'mimba,
kuchuluka kwa zotupa ndi zilonda zam'mimbamo zam'mimba,
kufupika kwa lactase, tsankho lactose, shuga-galactose malabsorption syndrome,
mphumu ya bronchial chifukwa chogwiritsa ntchito mankhwala osapweteka a anti-yotupa komanso ma salicylates, kuphatikiza kwaposachedwa kwa polyposis a paranasal sinuses ndi mphuno, mphumu ya bronchial ndi hypersensitivity ku ASA,
nthawi ya pakati (oyambilira ndi oyamba atatu),
nthawi yoyamwitsa,
ana ndi achinyamata osakwana zaka 18,
ntchito munthawi yomweyo ndi methotrexate mu 15 ml kapena kuposa,
kuchuluka kwamalingaliro amtundu uliwonse pazinthu zilizonse za mankhwalawa komanso mankhwala ena osapweteka a antiidal.

Wachibale (ASK-Cardio imagwiritsidwa ntchito mosamala):

wofatsa mpaka polephera chiwindi,
wofatsa mpaka pakati paimpso,
matenda opumira kwambiri,
Mphumu ya bronchial,
mbiri yakutuluka magazi m'mimba kapena zotupa m'mimba
polyposis ya mphuno,
hay fever
Hyperuricemia
gout
Vitamini K akusowa
ziwengo
kuchuluka kwa shuga-6-phosphate dehydrogenase,
nthawi yapakati (wachitatu trimester),
ochita opareshoni
munthawi yomweyo kugwiritsa ntchito mankhwala enaake (okhala ndi antiplatelet, anticoagulant, kapena othandizira ma thrombolytic, ibuprofen, digoxin, methotrexate (pa mlingo wa sabata zochepa zosakwana 15 mg), valproic acid, kusankha kwa mankhwala a serotonin. makonzedwe amkamwa ndi insulin, mankhwala osokoneza bongo omwe amaletsa kutupa ndi mowa).

Mlingo ndi makonzedwe

ASA Cardio amatengedwa pakamwa atatha kudya. Piritsi siimata, kutsukidwa ndi madzi ambiri.

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Monga othandizira antiplatelet, mankhwalawa amatengedwa kwa nthawi yayitali.

Mlingo woyenera:

kupewa kupewa pachimake myocardial infarction (ngati akukayikira kuti ayambitse): mlingo woyambayo ndi 100-300 mg, mankhwalawa ayenera kumwedwa pambuyo pake pakukayikira kuti chitukuko cha kulowetsedwa pachimake chachitika (pakupeza mwachangu, piritsi loyamba la mankhwalawa liyenera kutafunidwa). Mlingo wokonza pambuyo pokhazikitsa infracation ya 200 ndi 200 mg tsiku lililonse kwa masiku 30,
kupewa kupewa pachimake myocardial infaration amene adayamba kwa nthawi yoyamba (pamaso pangozi): 100 mg kamodzi patsiku kapena 300 mg tsiku lililonse lililonse,
kupewa pulmonary embolism ndi nthambi zake, komanso vein thrombosis: 100-200 mg patsiku kapena 300 mg tsiku lililonse lililonse,
Zizindikiro zina: 100-300 mg patsiku.

Zotsatira zoyipa

kugaya chakudya dongosolo: Nthawi zambiri - kusanza, nseru, kupweteka m'mimba, kutentha kwa pamtima, kawirikawiri - kutaya magazi kuchokera m'mimba, zilonda zam'mimba ndi m'mimba (kuphatikizapo kuphatikizidwa), kuchuluka kwa ntchito ya hepatic transaminases (kanthawi kochepa),
Mtima wamitsempha: kawirikawiri - kutupa kwamiyendo, kuwonjezeka kwa matenda osalephera a mtima,
hematopoietic dongosolo: intra- ndi postoperative magazi, magazi m`kamwa, hematomas, magazi kuchokera ku genitourinary thirakiti, nosebleeds, hemorrhage mu ubongo, pachimake kapena matenda a posthemorrhagic / iron kuchepa magazi, mwa odwala kwambiri glucose-6-phosphate dehydrogenase ndipo hemolysis
chapakati mantha dongosolo: tinnitus, kusamva makutu, chizungulire,
kwamikodzo dongosolo: Matenda aimpso, kusowa kwa impso,
thupi lawo siligwirizana: bronchospasm, kuyabwa pakhungu, rhinitis, urticaria, Cardio-kupuma mavuto matenda, Quincke edema, kutupa kwa mphuno mucosa, anaphylactic mantha.

Malangizo apadera

Mankhwala ASK-Cardio ayenera kugwiritsidwa ntchito pokhapokha ngati akuwuzani dokotala.

Pa Mlingo wotsika, ASA imatha kudwala matenda otupa.

Mlingo waukulu wa mankhwalawa umakhala ndi vuto la hypoglycemic, lomwe liyenera kuganiziridwa popereka mankhwala kwa odwala omwe ali ndi matenda osokoneza bongo omwe amalandila insulin kapena mankhwala amkamwa a hypoglycemic.

Ngati mlingo wa ASK-Cardio ukachulukitsidwa, chiopsezo chotenga magazi m'matumbo chikuwonjezeka.

Kwa odwala okalamba, kumwa mankhwala osokoneza bongo mopitirira muyeso ndi koopsa kwambiri.

Pa chithandizo, chisamaliro chikuyenera kuchitika mukamagwira ntchito yomwe imakhudzana ndi chidwi chachikulu komanso kuthana kwachangu (kuyendetsa galimoto, ntchito ya wothandizira ndi wotulutsa, ndi zina).

Kuyanjana kwa mankhwala

Pogwiritsa ntchito munthawi yomweyo ASA-Cardio, imathandizira zotsatira zowonjezera komanso zovuta zotsatirazi: . Ngati pakufunika kugwiritsa ntchito ASA nthawi yomweyo ndimankhwala omwe atchulidwa, tikulimbikitsidwa kuti muganizire zochepetsa Mlingo wawo.

Mukagwiritsidwa ntchito limodzi ndi Mlingo wambiri, ASA-Cardio imafooketsa zotsatira za mankhwala otsatirawa: diuretics iliyonse, angiotensin-kutembenuza enzyme inhibitors, oricosuric agents (probenecid, benzbromarone), systemic glucocorticosteroids (kupatula hydrocortisone, yomwe imagwiritsidwa ntchito m'malo mwa kuwonjezera mankhwala. Ngati pakufunika kugwiritsa ntchito ASA limodzi ndi mankhwala omwe atchulidwa, tikulimbikitsidwa kuti muganizire za kusintha kwa mlingo.

Kukonzekera kwina kwa acetylsalicylic acid

Mlingo ndi makonzedwe

ASA Cardio amatengedwa pakamwa atatha kudya. Piritsi siimata, kutsukidwa ndi madzi ambiri.

Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Monga othandizira antiplatelet, mankhwalawa amatengedwa kwa nthawi yayitali.

Mlingo woyenera:

kupewa kupewa pachimake myocardial infarction (ngati akukayikira kuti ayambitse): mlingo woyambayo ndi 100-300 mg, mankhwalawa ayenera kumwedwa pambuyo pake pakukayikira kuti chitukuko cha kulowetsedwa pachimake chachitika (pakupeza mwachangu, piritsi loyamba la mankhwalawa liyenera kutafunidwa). Mlingo wokonza pambuyo pokhazikitsa infracation ya 200 ndi 200 mg tsiku lililonse kwa masiku 30,
kupewa kupewa pachimake myocardial infaration amene adayamba kwa nthawi yoyamba (pamaso pangozi): 100 mg kamodzi patsiku kapena 300 mg tsiku lililonse lililonse,
kupewa pulmonary embolism ndi nthambi zake, komanso vein thrombosis: 100-200 mg patsiku kapena 300 mg tsiku lililonse lililonse,
Zizindikiro zina: 100-300 mg patsiku.

Angina wosakhazikika,
kupewa ngozi zaposachedwa kwambiri.
kupewa kwa thromboembolism kwa chotupa cha m'mapapo ndi nthambi zake, komanso vein thrombosis (mwachitsanzo, ndi kusakhazikika kwa nthawi yayitali chifukwa chakuchita opaleshoni yayikulu),
kupewa matenda opha ziwalo (kuphatikizapo odwala omwe ali ndi matenda osakhalitsa a cerebrovascular matenda),
kupewa kupewa pachimake myocardial kulowetsedwa vuto la chimodzi kapena zingapo zoopsa (ochepa matenda oopsa, matenda a shuga, kunenepa kwambiri, hyperlipidemia, ukalamba, kusuta fodya), kupewa kulowetsedwa kwa myocardial,
kupewa thromboembolism pambuyo zowononga ndi opaleshoni ya mtima (mwachitsanzo arteriovenous bypass, corteryary artery bypass grafting, carotid artery angioplasty, carotid artery endarterectomy).

Zotsatira zoyipa

Matumbo oyenda: Nthawi zambiri - kusanza, nseru, kupweteka pamimba, kutentha kwa mtima, osawerengeka - kutuluka kwa magazi m'mimba, zilonda zam'mimba ndi m'mimba (kuphatikizapo kuphatikizidwa), kuchuluka kwa hepatic transaminases (kwakanthawi).

Mtima wamtima: kawirikawiri - kutupa miyendo, kuwonjezeka kwa matenda osalephera a mtima.

Hematopoietic dongosolo: intra- ndi postoperative magazi, magazi amkamwa, hematomas, kutuluka magazi kuchokera ku genitourinary thirakiti, nosebleeds, zotupa mu ubongo, pachimake kapena matenda a pambuyo-hemorrhagic / iron kuchepa magazi, mwa odwala kwambiri glucose-6-phosphate dehydrogenase akusowa - hemolytic anemia ndi.

Pakati mantha dongosolo: tinnitus, kumva kuwawa, chizungulire.

Njira yamikodzo: chosokoneza impso ntchito, pachimake aimpso kulephera.

Thupi lawo siligwirizana: bronchospasm, khungu kuyabwa ndi zidzolo, rhinitis, urticaria, Cardio-kupuma nkhawa syndrome, edema ya edincke, kutupa kwa mphuno mucosa, anaphylactic.

Bongo

Zizindikiro za kuchuluka kwa zolimbitsa kukula: nseru, kusanza, tinnitus, kumva, chizungulire, chisokonezo.
Chithandizo: kuchepetsa mlingo.

Zizindikiro za kwambiri bongondi: fever, hyperventilation, ketoacidosis, kupuma alkalosis, chikomokere, mtima ndi kupuma, kulephera kwambiri kwa hypoglycemia.
Chithandizo: Kuthamangitsidwa kuchipatala m'madipatimenti apadera othandizira chithandizo chamankhwala - chifuwa cham'mimba, kutsimikiza kwa acid-base, alkaline ndi kukakamizidwa kwa zamchere, hemodialysis, kuyang'anira mayankho, kuyambitsa makala, chizindikiro.

Mlingo wowonjezera wa ASA umagwirizanitsidwa ndi chiopsezo cha kutaya magazi m'matumbo. Mankhwala osokoneza bongo oopsa kwambiri odwala okalamba.

Mapangidwe piritsi limodzi:

ntchito: acetylsalicylic acid 100 mg,
zokopa:
pachimake: lactose monohydrate (mkaka wa shuga) 15,7 mg, povidone (polyvinyl pyrrolidone) 0,16 mg, mbatata wowuma 3.57 mg, talc 0.2 mg, stearic acid 0 mg
chipolopolo: methaconic acid ndi ethacrylate kopolymer 1: 1 (colicoate MAE 100) 4.186 mg, macrogol-6000 (maselo akuluakulu polyethylene glycol) 0,558 mg, talc 1.117 mg, titanium dioxide 0,139 mg.

mapiritsi a biconvex wozungulira, wokutidwa ndi chipolopolo choyera. Gawo la mtanda pakati ndi loyera.

Gulu la Pharmacotherapeutic:

Mankhwala
Acetylsalicylic acid (ASA) ndi salicylic acid ester, ali m'gulu la mankhwala omwe si a antiidal a antiidal (NSAIDs). Makina ochitapo kanthu amatengera kusinthika kwachilengedwe kwa cycloo oxygenase (COX-1), chifukwa chomwe kuphatikiza kwa ma prostaglandins, ma prostogia ndi thromboxane amaletseka. Amachepetsa kusakanikirana, kuphatikiza mapulateleti ndi thrombosis poletsa kaphatikizidwe ka thromboxane A₂ m'mapulateleti. Imawonjezera ntchito ya fibrinolytic ya plasma yamagazi ndikuchepetsa kuchuluka kwa mavitamini a K-amadalira a vitamini K (II, VII, IX, X). Mphamvu ya antiplatelet imayamba kugwiritsidwa ntchito ngati mulingo wochepa wa mankhwalawa ndikupitilira kwa masiku 7 mutatha kamodzi. Izi zimatha ASA ntchito popewa komanso kuchiza infarction ya mtima, matenda a mtima, zovuta za mitsempha ya varicose. ASA yapamwamba kwambiri (oposa 300 mg) ali ndi anti-yotupa, antipyretic ndi analgesic kwenikweni.

Pharmacokinetics
Pambuyo pakukonzekera pamlomo, ASA imatengedwa mwachangu komanso kwathunthu kuchokera ku thirakiti la m'mimba (GIT). ASA imapangidwa pang'ono pakamwa. Pakumizidwa kapena pambuyo pake, ASA imatembenuka kukhala metabolite yayikulu - salicylic acid, yomwe imapangidwa makamaka mu chiwindi mothandizidwa ndi ma enzymes ndikupanga ma metabolites monga phenyl salicylate, glucuronide salicylate ndi salicyluric acid, omwe amapezeka minofu yambiri komanso mkodzo. Mwa akazi, njira ya metabolic imayamba kuchepa (ntchito zochepa za ma enzymes mu seramu yamagazi). Kuchuluka kwa ASA mu madzi am'magazi kumatheka 10-30 mphindi pambuyo kumeza, salicylic acid - pambuyo 0,3-2 maola. Chifukwa chakuti mapiritsiwa amaphatikizidwa ndi chipolopolo chosagwira asidi, ASA imamasulidwa osati m'mimba (chipolopolo chimalepheretsa kupezeka kwa mankhwalawa m'mimba), koma m'malo a zamchere a duodenum. Chifukwa chake, mayamwidwe a ASA mu mawonekedwe a mapiritsi, mapiritsi okhala ndi mafilimu, okhala ndi mafilimu, amachepetsedwa ndi maola 3-6 poyerekeza ndi mapiritsi wamba (opanda zotchingira).
ASA ndi salicylic acid amamangirira kwambiri mapuloteni a plasma (kuchokera pa 66% mpaka 98% kutengera mlingo) ndipo amagawidwa mwachangu mthupi. Salicylic acid imawoloka placenta ndikuvumbulutsidwa ndi mkaka wamawere.
Kutupa kwa salicylic acid kumadalira mlingo, popeza kagayidwe kake kamachepa ndi mphamvu ya enzymatic system. Hafu yaumoyo imachokera ku maola awiri ndi atatu mukamagwiritsa ntchito ASA mu Mlingo wotsika komanso mpaka maola 15 mukamagwiritsa ntchito mankhwalawa muyezo waukulu. Mosiyana ndi ma salicylates ena, pogwiritsa ntchito mankhwalawa mobwerezabwereza, ASA yopanda hydrolyzed siziunjikira mu seramu yamagazi. Salicylic acid ndi ma metabolites ake amuchotsa impso. Odwala ndi yachilendo aimpso ntchito, 80-100% ya limodzi mlingo wa mankhwalawa amamuchotsa impso mkati mwa maola 24-72.

Zizindikiro zogwiritsidwa ntchito

angina wosakhazikika,
khola angina,
kupewa kwakukulu kwa kulowerera kwam'mnyewa wamtima pachimake pakachitika zinthu zoopsa (mwachitsanzo, matenda a shuga, matenda oopsa, matenda oopsa, kunenepa kwambiri, kusuta, kukalamba)
kupewa matenda a ischemic (kuphatikiza odwala omwe ali ndi vuto losakhalitsa la ubongo),
kupewa ngozi zaposachedwa kwambiri.
kupewa thromboembolism atachitidwa opaleshoni ndi zina zowononga zamitsempha (mwachitsanzo, kupanikizika kwa mitsempha yodutsa m'mitsempha, carotid artery endarterectomy;
kupewa kwamitsempha yama mtima ndi thromboembolism yam'mitsempha yam'mapapo ndi nthambi zake (mwachitsanzo, ndi kusakhazikika kwa nthawi yayitali chifukwa cha kulowererapo kwakukulu kwa opaleshoni).

Gwiritsani ntchito pa nthawi yoyembekezera komanso nthawi yoyamwitsa

Kugwiritsa ntchito mankhwalawa kumapangidwa panthawi ya pakati (I ndi III trimesters) komanso nthawi yoyamwitsa. Kugwiritsa ntchito milingo yayikulu ya salicylates m'miyezi itatu yoyambirira ya kubereka kumalumikizidwa ndi kufalikira kwa zolakwika za fetal (kugawanika kwa pakamwa, zolakwika za mtima). Mu trimester yachiwiri yokhudzana ndi kubereka, ma salicylates amatha kuyikidwa pokhapokha ngati akuwonetsetsa kuti ali pachiwopsezo komanso kupindula.
Mu trimester yomaliza yam'mimba, ma salicylates omwe ali ndi mlingo waukulu (wopitilira 300 mg / tsiku) amachititsa kufooka kwa ntchito, kutsekeka msanga kwa ductus arteriosus mu mwana wosabadwayo, kuchuluka kwa magazi m'mayi ndi mwana wosabadwayo, ndipo makonzedwe atangobadwa kumene amatha kuyambitsa kukha magazi kwakanthawi, makamaka ana akhanda. Kukhazikitsidwa kwa salicylates mu trimester yomalizira kumatsutsana.
Ma salicylates ndi ma metabolites awo ochepa amapita mkaka wa m'mawere. Kudya kwakanthawi kochepa kwa ma salicylates pa nthawi yoyamwitsa sikumayendetsedwa ndi kukhazikika kwa zinthu zoyipa mwa mwana ndipo sikutanthauza kuti kuyamwitsa kuyamwa. Komabe, pogwiritsa ntchito mankhwalawa kwa nthawi yayitali kapena kupatsidwa mlingo waukulu, kuyamwitsa kuyenera kuyimitsidwa nthawi yomweyo.

Mlingo, njira ya makonzedwe

ASA-Cardio ® iyenera kumwa mkamwa, makamaka asanadye, osafuna kutafuna, kumwa madzi ambiri.
ASK-Cardio® idapangidwa kuti izigwiritsidwa ntchito kwa nthawi yayitali. Kutalika kwa mankhwala kumatsimikiziridwa ndi adokotala. Popanda kupatsidwa malangizo ena, ndikofunikira kutsatira zotsatirazi:
Angina wosakhazikika (ndi chinyengo chamawonekedwe oyipa) Mlingo woyambirira wa 100-300 mg (piritsi loyamba liyenera kutafunidwa mwachangu) uyenera kumwedwa ndi wodwalayo posachedwa, pakukayikiridwa kwa chitukuko cha kulowerera kwa myocardial infarction. M'masiku 30 otsatira chitukuko cha kulowetsedwa kwa myocardial, mlingo wa 200-300 mg patsiku uyenera kupitilizidwa.
Kupewera koyambirira kwa kulowetsedwa kwachimake myocardial pamaso pa zinthu zoopsa 100 mg patsiku kapena 300 mg tsiku lililonse.
Kupewa kwa myocardial infarction. Wosakhazikika komanso wosakhazikika wa angina pectoris. Kupewa kwa ischemic sitiroko ndi kanthawi kochepa ka magazi. Kupewa kwa thromboembolism pambuyo pakuchita opaleshoni ndikulowerera kwa mtima kosafunikira 100-300 mg patsiku.
Kupewa kwambiri kwamitsempha yotupa ndi thromboembolism yam'mitsempha yamagazi ndi nthambi zake 100-200 mg patsiku kapena 300 mg tsiku lililonse lililonse.

Kuchita ndi mankhwala ena

Ndi kugwiritsa ntchito nthawi yomweyo kwa ASA kumathandizanso kuchitapo kanthu kwa mankhwala otsatirawa, ngati kuli kotheka, kugwiritsa ntchito nthawi yomweyo kwa ASA ndi ndalama zomwe zalembedwa ziyenera kuganizira kufunika kochepetsera mlingo wa mankhwalawa:
- methotrexate, chifukwa cha kuchepa kwa chilolezo cha impso ndi kuchoka kwake pakuyankhulana ndi mapuloteni,
- kugwiritsa ntchito nthawi imodzi ndi anticoagulants, thrombolytic ndi antiplatelet agents (ticlopidine, clopidogrel), pamakhala chiwopsezo chotaya magazi chifukwa cha synergism yamankhwala omwe amagwiritsidwa ntchito,
- kugwiritsa ntchito munthawi yomweyo mankhwala osokoneza bongo okhala ndi anticoagulant, thrombolytic kapena antiplatelet effect, pali kuwonjezeka kwa zomwe zimapangitsa kuwonongeka kwa mucous membrane am'mimba.
- kusankha serotonin reuptake inhibitors, zomwe zingapangitse chiopsezo chowonjezereka cha magazi kuchokera kumtunda wapamwamba wam'mimba (synergism ndi ASA),
- digoxin, chifukwa cha kuchepa kwa impso zake, zomwe zingayambitse bongo.
- othandizira a hypoglycemic operekera pakamwa (sulfonylurea zotumphukira) ndi insulin chifukwa cha hypoglycemic katundu wa ASA yokha pamlingo waukulu komanso kusamutsidwa kwa zotumphukira za sulfonylurea kuchokera kumayanjana ndi mapuloteni amadzi a m'magazi,
- yogwiritsidwa ntchito munthawi yomweyo ndi valproic acid, poizoni wake umachulukanso chifukwa chosagwirizana ndi mapuloteni amadzi a m'magazi,
- NSAIDs ndi salicylic acid omwe amapezeka pamlingo wambiri (chiwopsezo chachikulu cha ulcerogenic zotsatira ndi magazi am'mimba chifukwa cha synergistic kanthu), mukagwiritsidwa ntchito ndi ibuprofen, pamakhala kukangana chifukwa cha kuponderezana kosasinthika chifukwa cha ASA, komwe kumabweretsa kuchepa kwa zotsatira zama mtima. FUNSANI,
- Ethanol (chiwopsezo chowonjezereka cha kuwonongeka kwa mucous membrane wam'mimba komanso nthawi yayitali yotuluka magazi chifukwa chothandizana ndi ASA ndi Mowa),
- Pogwiritsa ntchito munthawi yomweyo acetylsalicylic acid (monga wothandizira antiplatelet) ndi ma blocker a njira "zakuchera" za calcium, chiopsezo chotulutsa magazi chikuwonjezeka.
- Mukagwiritsidwa ntchito nthawi yomweyo ndi kukonzekera golide, acetylsalicylic acid imatha kuyambitsa chiwindi.

Ndi kugwiritsa ntchito nthawi yomweyo kwa ASA muyezo waukulu, imachepetsa mphamvu ya mankhwala omwe ali pansipa, ngati kuli kotheka, makonzedwe omwewo a ASA omwe ali ndi mankhwalawa atchulidwa ayenera kuganizira za kufunika kosintha kwa mankhwalawa:
- diuretics iliyonse (ikaphatikizidwa ndi ASA mu Mlingo wambiri, kuchepa kwa kuchuluka kwa kusefera kwa madzi (GFR) chifukwa chakuchepa kwa kapangidwe ka ma prostaglandins mu impso),
- zoletsa za angiotensin zotembenuza enzyme (ACE) (kuchepa kwa mlingo wa GFR) zimawonedwa chifukwa cha kuletsa kwa ma prostaglandins ndi zotsatira za vasodilating, motero, kufooka kwa zotsatira za hypotensive. Amapereka kwa odwala zochizira matenda a mtima Kulephera. Mphamvu iyi imawonekeranso pakagwiritsidwa ntchito molumikizana ndi ASA kwakukulu Mlingo)
- mankhwala a uricosuric kanthu - benzbromaron, probenecid (kuchepa kwa uricosuric chifukwa chifukwa cha kuponderezana kwa impso tubular urinary acid excretion),
- kugwiritsa ntchito munthawi yomweyo ndi glucocorticosteroids (kupatula hydrocortisone, wogwiritsidwa ntchito m'malo mwa chithandizo cha matenda a Addison), pakuwonjezereka kwa ma salicylates ndipo motero, kufooka kwa zomwe akuchita.
Maantacid okhala ndi magnesium ndi / kapena aluminiyamu amachepetsa ndikuletsa mayamwidwe a acetylsalicylic acid.

Kukopa pa kuyendetsa magalimoto, machitidwe

Munthawi ya chithandizo, kusamala kuyenera kuchitika pochita zinthu zoopsa zomwe zimafunikira chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor (kuyendetsa magalimoto, kugwira ntchito ndi njira zosunthira, ntchito ya woyendetsa ndi wothandizira, etc.), monga chizungulire.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amaperekedwa mu mawonekedwe a mapiritsi - wopanga sanapereke mitundu ina ya mlingo. Mtundu wa mapiritsiwo ndi woyera, mawonekedwe ake ndi ozungulira, wokutidwa ndi nembanemba womwe umasungunuka m'matumbo pambuyo pa makonzedwe.

ASA Cardio ndi mankhwala osapweteka a antiidal omwe ali ndi katundu wochiritsa.

Mapiritsi ali mumtundu wa zidutswa 10. Matumba ali ndi zonyamula makatoni. Kuti zitheke kwa wogula, mapaketi amakhala ndi matuza osiyanasiyana - 1, 2, 3, 5, 6, kapena 10 zidutswa.

Ma tebulo amathandizidwanso mumatumba amtundu wa polymer. Wopanga amapereka mitsuko yokhala ndi mapiritsi osiyanasiyana - 30, 50, 60 kapena 100.

Mphamvu ya mankhwalawa yamankhwala imachitika chifukwa cha zomwe zimagwira, zomwe ndi ASA (acetylsalicylic acid). Piritsi lililonse lili ndi 100 mg. Kupititsa patsogolo kuthekera kwa mapiritsi, zina zowonjezera zimaphatikizidwa - stearic acid, polyvinylpyrrolidone, etc.

Zotsatira za pharmacological

Mankhwala amatha kuthana ndi kutentha, amakhala ndi mphamvu yokhudza ma analgesic, amatha kuthana ndi kuphatikizika kwa maselo a magazi. Chifukwa cha kukhalapo kwa acetylsalicylic acid mu kapangidwe kake, mankhwalawa amathandizira kupewa kupweteka kwamatenda ndi myocardial infiration kwa anthu omwe ali ndi vuto losakhazikika la angina pectoris.

Munthu amene amamwa mankhwala othandiza kupewa amachepetsa chiopsezo cha kukonzanso kwa matenda a mtima. Mankhwala ngati prophylactic amachepetsa chiopsezo cha kuundana kwa magazi.

Pharmacokinetics

Popita kwakanthawi, ASA imalowetsedwa kwathunthu kuchokera m'mimba, ndikusintha kukhala salicylic acid, yomwe ndiyo metabolite yayikulu. Enzymes amachita asidi, motero, imapangidwa mu chiwindi, ndikupanga metabolites ena, kuphatikizapo glucuronide salicylate. Ma metabolabolites amapezeka mumkodzo komanso zimakhala zosiyanasiyana za thupi.

The ambiri ndende ya yogwira mankhwala m'magazi amawona osakwana theka la ola mutamwa mapiritsi.

Hafu ya moyo wa mankhwala zimatengera mlingo anatengedwa. Ngati mankhwalawa amamwa pang'onopang'ono, ndiye kuti nthawi yake imatenga maola awiri ndi atatu. Mukamamwa Mlingo waukulu, nthawi imawonjezeka mpaka maola 10-15.