Mankhwala Mildronate: malangizo ntchito

"Meldonium" mopanda mantha ikhoza kuphatikizidwa ndi mankhwala omwe amasintha microcirculation. Kuphatikiza apo, mankhwalawa amagwirizana ndi mtima glycosides, nitrate wokhala ndi nthawi yayitali.

Mankhwalawa amalimbikitsa machitidwe a vasodilators, adrenergic blockers. Imayanjana bwino ndi mankhwala othandizira Edzi.

Sitikulimbikitsidwa kuphatikiza ndi mankhwala ozikidwa pa cyclophosphamide ndi ifosfamide chifukwa choopsa cha matenda a mtima. Kuphatikiza apo, sikulimbikitsidwa kugwiritsa ntchito mankhwala ena opangidwa ndi meldonium nthawi imodzi, chifukwa chowonjezera chiopsezo chotenga zochitika zoyipa.

Mankhwala omwe ali ndi gawo lofananalo popanga amatchedwa analogues. Pakati pawo, amasiyana ndi dzina lamalonda, kampani yopanga, nthawi zambiri yamitengo ndi mtundu.

Zina mwazifanizo za "Meldonium" ndizokonzekera: "Mildronate", "Flowerpot", "Metamax", "Milocard-N", "Vazopro", "Metonat", "Mildrakor". Matenda a shuga amalola kugwiritsa ntchito mitundu yonse ya Meldonium.

Sitikulimbikitsidwa kuti musinthane mankhwalawa nokha, ndizotheka kuchita izi pokhapokha mukaonana ndi dokotala.

Contraindication

Kugwiritsa ntchito kwa Mildronate mu zotupa za muubongo komanso kuchuluka kwachuma kwamkati sikulimbikitsidwa. Kuphatikiza apo, sikulimbikitsidwa kuti mugwiritse ntchito mankhwalawa pochiza machitidwe omwe akuphatikizidwa ndi mkodzo wotupa wochokera ku ziwiya zaubongo.

• kusalolera kwa munthu wagawo kapena mankhwala ena ake
• kuchuluka kwazovuta zamkati,
• kuwonongeka kwa organic system,
• kukanika kwambiri kwa hepatic ndi / kapena kulephera kwa impso,
• nthawi yapakati
• Nthawi yonyamula mkaka
• ana ochepera zaka 18.

Ndemanga Zapamwamba

Mankhwalawa agwiritsidwa ntchito kuyambira kalekale pazamankhwala, kotero pali kuwunika kambiri pazakuchita kwake.

Igor, wazaka 45, Rostov-on-Don

Kristina, wazaka 38, Vladivostok

Ndakhala ndikuchiza matenda opha ziwalo kwa zaka zoposa 12. Nthawi zambiri ndimapereka mankhwala a Mildronate kwa odwala anga. Chida ichi sichabwino kwa odwala omwe ali ndi chidwi chambiri, koma nthawi zina samakhala m'malo. Zimathandizira pakuchotsa mwachangu kwa zotsalira za pathological phenomena, zomwe zimapangitsa odwala kukhala osavuta kudutsa nthawi yokonzanso.

Vladimir, wazaka 43, Murmansk

Mankhwala amatha kusintha zomwe zimakhala ndi mtima wamunthu. Chifukwa cha antihypoxic ndi antioxidant zotsatira, chida ichi chimathandiza kukhazikika mtima ndikuwonjezera kukana kuzunzika kwakuthupi komanso machitidwe a zinthu zosiyanasiyana zoyipa.

Irina, wazaka 82, Moscow

Igor, wazaka 45, Ryazan

Kuunikira kwa antihypoxic magwiritsidwe a meldonium mu kusokonezeka kwa microvasculature odwala omwe ali ndi mtundu 2 shuga mellitus | Mbiri

Korpachev V.V., Korpacheva-Zinich O.V., Gurina N.M., Kovalchuk A.V., Kushnareva N.N., Shishkan-Shishova K.A., Nailed O.V.

Matenda a shuga mellitus (DM) ndi vuto lofunika mwachangu, chifukwa cha kuchuluka kwake, chizolowezi chomakulitsa odwala, komanso kupezeka kwa zovuta zina.

Ntchito yofunikira ndikukhazikitsa njira zatsopano zopewera komanso kuchiza matenda ashuga, omwe cholinga chake ndi kuchepetsa chiopsezo cha kukula ndi kupitilira kwa zovuta zam'magazi ochepa komanso ochepa. DM imadziwika ndi zovuta za polymetabolic zomwe zimaphimba maulalo onse a metabolic.

Kuphwanya kugwiritsidwa ntchito kwa magawo akuluakulu amagetsi kumayendera limodzi ndi kuchepa kwa mphamvu pakusinthana kwa mphamvu, kuchepa kwa zosungidwa zamapangidwe apachilengedwe, komanso kuwonjezeka kwa njira zosinthira.

Odwala a shuga a Type 2 ali m'dera la chiwopsezo chowonjezereka cha zotulukapo ndi zovuta za mtima, zomwe zimapangitsa kusintha kwa oxygenation ya minofu yonse ndi ziwalo.

Makamaka, zotsatirapo za nthawi yayitali matenda a ischemia ndi hypoxia ya minyewa yam'munsi ya miyendo ndikukula kwa zotumphukira za matenda a shuga a neuro- ndi angiopathy.

Yotsirizirayi imadziwika ndi kuphatikiza kwapawiri konsekonse kwamitsempha yayikulu komanso yayikulu (macroangiopathy) ndi microvasculature (zotumphukira za microangiopathy).

Ngakhale pakalibe zovuta zotupa za ziwiya zazikuluzikulu za odwala omwe ali ndi matenda ashuga, zovuta zazing'ono zam'magazi zimadziwika nthawi zambiri, limodzi ndi kusintha kwakukulu kwa metabolic. Chifukwa chake, kayendedwe ka okosijeni, kayendedwe kake ndikugwiritsira ntchito minofu ndizizindikiro zofunika kwambiri pakugwira ntchito kwa machitidwe othandizira moyo, ndipo kuwunika kwawo kokwanira kumafunikira kusankha njira zoyenera ndi njira zamankhwala za wodwala aliyense payekhapayekha.

Kuphunzira ma microcirculation, njira za radionuclide (scintigraphy), video capillaroscopy, intravital microscopy ndi / osagwiritsa ntchito inks fluorescent, laser Doppler flowmetry, polarographic transcutaneous oximetry amagwiritsidwa ntchito.

Posachedwa, njira yowerengera makanema ojambula pamanja, kuphatikiza ukadaulo wa makompyuta a X-ray ndi angiography ndi makonzedwe amkati mwa utoto wosiyanitsa, womwe umathandiza kuwona m'mitsempha yamagazi ndikuyenda kwa magazi mkati mwawo, ndiyo njira yayikulu yowunikira kuchuluka kwa zotupa za atherosulinotic.

Komabe, polosera komanso kuchiza zotupa za matenda am'mimba a m'munsi, miyeso ya okosijeni ya okosijeni pang'ono (kupsinjika) (transcutaneous oxygen pressure - tcpO2) ndiye muyezo wagolide woyesa minofu oxygenation (Gamzina A.E. et al., 2010).

Maziko a njirayi ndikutsimikiza kochulukirapo kwa mpweya wamagalasi mwanjira yosavomerezeka pogwiritsa ntchito ma elekitirodi oyatsidwa pamwamba pake.

Kuyeza kwa tcpO2 kumakhazikitsidwa potsatira kuwunika kwa polarographic kwa okosijeni mu zinthu zachilengedwe ndipo kumalola wina kuti aweruze ntchito ya kayendedwe ka magazi a khungu ndi kuphatikizika kwa oxygen m'misempha.

Kutha kubwezeretsa kagayidwe kazakudya mu mtima m'magawo am'munsi mwachindunji kumadalira kuchuluka kwa kuwonongeka kwa microvasculature, komwe kungayang'anitsidwe ndi transcutaneous oximetry data.

Kutengera mtengo wa tcpO2, magawo otsatirawa a kusokonezeka kwa microcircular komanso minofu metabolism amasiyanitsidwa:

• Ine (minofu yolipirira minofu) - tcpO2> 30 mm RT. Art.
• II (minofu yolowerera minyewa) - tcpO2 = 20-30 mm Hg. Art.
• ІІІ (metabolism minofu) - tcpO2 40 mm Hg. Art. (Rooke T., 1998) .Zowonetsa za kubwezeretsanso kwa kagayidwe kazinthu kakang'ono ndi kuchepa kwa okosijeni pamlingo wama cellcirculatory mwachindunji zimakonza molunjika ndi kuchuluka kwa kuwonongeka kwa kama wamitsempha. Kuopsa kwa zovuta zam'magazi am'mimba komanso kukana kwa kagayidwe kazakudya kwa ischemia kumazindikira kukula kwa minyewa ya miyendo. Kuphatikiza kwa mankhwala omwe amakhudza bwino boma la micro-rheology ndikuwonetsetsa kuti minyewa yokwanira yochepa ku Ukraine, zomwe zimapangitsa kusaka kwa mankhwala atsopano kapena kusanthula kwazinthu zomwe sizinapezeke. ndi meldonium - mawonekedwe analogue a γ-butyrobetaine okhazikika a carnitine. Carnitine amachita ngati chonyamula mafuta acids (ma FA) kudzera mu membrane kupita mu mitochondria, kumene ma occurs-oxidation awo amapezeka (Titov V.N., 1997, Kalvinsh I.Ya., 2001, Soloshenko O., 2010). Meldonium, yogwira ngati mpikisano wopikisana ndi enzyme γ-butyrobetaine hydroxylase, imachepetsa kuchuluka kwa biosynthesis ya carnitine kuchokera ku γ-butyrobetaine.Nthawi yomweyo, mulingo wa carnitine umatsika mu cytosol, zochepa za FA zimabwera mu mitochondria, zomwe zimapangitsa kuchepa kwa okosijeni a FA komanso kusintha kwa kagayidwe kachakudya kogwiritsa ntchito oxygen mwachuma kwambiri mwa kutulutsa mphamvu zamagulu ochulukitsa. Pakati pa okosijeni a glucose, poyerekeza ndi β-oxidation of FAs, mtengo wowerengeka wa ATP wopangidwa mamolekyulamu onse a okosijeni omwe amamwa ndi 12-13% kuposa. Chifukwa cha izi, kupulumutsa kwa mpweya wa meldonium kumazindikirika. Njira zakuchitikira kwa trimethylhydrazinium propionate (meldonium) Kudzikundikira kwa γ-butyrobetaine kumawonjezera bioavailability wa NO - endothelial vasodilation factor, yomwe imapangitsa kuti magwiridwe antchito amtundu wa endothelium ndi, motsatana, kuvomerezedwa kwa mitsempha yodwala. Ya., 2001, Baumane L. et al., 2002). Njira yopangira kuchuluka kwa NO ndikugwiritsa ntchito meldonium imalumikizidwa ndi kukondoweza kwa NO biosynthesis ndi kuchepa kwa kusapangika kwake ndi maulere aulere. Meldonium imawonjezera ntchito ya michere yofunika kwambiri mu okosijeni wa aerobic glucose oxidation - hexokinase ndi pyruvate dehydrogenase, ndikuletsa acidosis pochepetsa mapangidwe a lactate. Kukhathamiritsa kwa mphamvu kagayidwe, komanso kupewa kupewa kuwonongeka kwakanthawi kwamankhwala a mitochondrial, kumathandizanso kuphatikiza kwa oxidation ndi phosphorylation ndikuwonjezera kaphatikizidwe ka ATP. Kuzindikira zotsatira zabwino za meldonium (kutchulidwa kwa anti-ischemic, antioxidant, anti-hyperglycemic), kugwiritsidwa ntchito kwake mwa mitundu iwiri ya mankhwala choyenera. Kuchepetsa kumwa kwa okosijeni mthupi lonse ("kuphunzitsidwa kwa metabolic", kapena kuwongolera minofu), kumathandizira makulidwe a glucose, kupewa kuchulukana kwa FA-under-oxidised free FA ndi chitukuko cha lactic acidosis, komanso kuchepetsa kuperewera kwa endothelial, kutsegulira chiyembekezo chakugwiritsa ntchito kwake kwakukulu pamachitidwe azachipatala. Kuwongolera kwa metabolic ndikofunikira kwambiri pamavuto a matenda ashuga monga matenda ashuga a m'munsi .Cholinga cha phunziroli ndi kuphunzira za meldonium (Trizipin, Mikrokhim, Ukraine) pamadera a microvasculature odwala omwe ali ndi matenda a shuga a 2 omwe ali ndi miyendo yaying'ono.
  

Njira ndi kafukufuku

Phunziroli lidaphatikizapo odwala 30 omwe ali ndi matenda a shuga a 2 (amuna 15 ndi azimayi 15), omwe adawonedwa ku dipatimenti ya Age-Endocrinology and Clinical Pharmacology, State Institution "V.P. Institute of Endocrinology and Metabolism" Komissarenko ". Kuphatikiza njira: kupezeka kwa matenda ashuga a mtundu wa 2, matenda a microangiopathy, matenda amkati, matenda oopsa, kusowa kwa kufalikira kwa mathero am'munsi, omwe adayesedwa pamaziko a rheovasography (RVH) ndi index ya ankle-brachial. m`mnyewa wamtima infarction, sitiroko, angina pectoris, ischemia, zolakwika zam'munsi, hypersensitivity kuyezetsa mankhwala, concomitant chiwindi matenda (chiwindi, matenda enaake), aimpso kugwiritsa ntchito mankhwala a meldonium kapena analogues ake, mankhwala okhala ndi vasodilation katundu, mankhwala a nootropic.Upakati wazaka zomwe ophunzira amakhala nawo azaka za 56 ± 2,5, akazi - 60.9 ± zaka 2.1, nthawi yayitali ya matenda oyamba - 10,7 ± Zaka 0.8 Mulingo wa hemoglobin wa glycated (HbA1c) ndi 8.8 ± 0,4%. Makhalidwe ambiri a odwala ndi kuwunika kwa RVG amaperekedwa pagome. 1 ndi 2. Tebulo 1 Mitundu yonse ya ophunzira

Tebulo 2 Chithunzithunzi RVG

Trizipine (jekeseni) anali kutumikiridwa m`mitsempha 500 mg (5 ml) kwa masiku 10 munthawi ya mankhwala omwe ali ndi vuto loyambitsa (mkamwa antihyperglycemic othandizira), komanso zovuta (α-lipoic acid, benfotiamine) pansi pamavuto mapiritsi otulutsidwa (Trizipin otalika) pa mlingo wa 1000 mg kamodzi patsiku kwa masiku 56. Cl Njira zamankhwala, zamankhwala zasayansi ndi zothandizira pakugwiritsa ntchito zinagwiritsidwa ntchito. Kuyesedwa kwakuthupi kunachitika, kuphatikizapo kutsimikiza kwa ziwonetsero za anthropometric, kutsatiridwa ndi kuwerengera kwa BMI, ndipo kuthamanga kwa magazi ndi kugunda kwa mtima kunayezedwa. Tidasanthula magawo a biochemical (cholesterol, triglycerides, okwera, otsika kwambiri komanso ochepa otsika lipoprotein cholesterol, atherogenic index, creatinine, bilirubin, alanine aminotransferase - AlAT, aspartate aminotransferase - AsAT). Miyezo ya HbA1c (D-10 ™, BIO-RAD), insulin (ARHITECT ci8200, Abbot) ndi glucose othamanga a magazi adatsimikizidwanso. Kuwerengera kwa insulin kukana index HOMA-IR kunachitika malinga ndi njira yokhazikika. Kuwunikira kwa tсрО2 kunachitika pogwiritsa ntchito chipangizo cha TSM 400, ndipo kuwunikira kwa RVG kunachitika pogwiritsa ntchito njira yodziwunikira ya CARDIO 02-216. SF-36 yapamwamba yofunsa mafunso idagwiritsidwa ntchito kuyesa moyo wabwino (Ware J.E. et al., 1993). Pafunso lidaphatikizidwa ndi malo a 36 omwe ali m'magawo asanu ndi atatu: kugwira ntchito zolimbitsa thupi, kuchita masewera olimbitsa thupi, kupweteka kwa thupi, thanzi lathunthu, kuchita masewera olimbitsa thupi, kutengeka mtima, thanzi. Kuchita kwa mulingo uliwonse kumasiyana kuchokera pa 0-100, pomwe 100 ikuyimira dziko lonse la thanzi. Zotsatira zake zidatanthauzidwa ngati masikelo pamasamba 8. Ubwino wamoyo umayerekeza potengera kuchuluka kwa zomwe zapezedwa.Maphunziro a Laborator, tcpO2 ndikudzaza zolemba mafunso adachitidwa pazowunikira komanso atamaliza maphunziro awo. Kuchitira umboni pazotsatira kunachitika pogwiritsa ntchito pulogalamu ya OriginPro 8. Poyerekeza magulu awiri ndi magawidwe wamba azizindikiro zomwe zapezedwa, kuyeserera kwa ophunzira kunagwiritsidwa ntchito. Kukula kochepa kwambiri kwa p kunatsimikiziridwa. Kusiyana kwa zidziwitso kunawonedwa kukhala kofunikira p

Momwe mungatenge Mildronate a matenda ashuga?

Mtundu wachiwiri wa matenda ashuga, Mildronate amathandizira shuga m'magazi. Chifukwa chake, madokotala omwe amathandizira nthawi zambiri amapatsidwa mankhwala othandizira kupewa. Zotsatira zabwino zatsimikiziridwa mu okalamba komanso mwa achinyamata.

Chifukwa cha kudya kwa Mildronate, njira zama mankhwala zimathandizira, chifukwa thupi limapatsidwa mphamvu zamagetsi. Mankhwalawa amathandiza kukhutitsa minofu ya mtima ndi mpweya, womwe umaperekedwa kwa myocardium.

Kugwiritsa ntchito matenda a shuga a Mildronate mu mtundu wa 2 kumathandizira pamavuto omwe matendawa amayambitsa:

• mankhwalawa amagwiritsidwa ntchito nthawi ya infa isanachitike,
• chida chimagwiritsidwa ntchito popititsa patsogolo kupirira kwa thupi la anthu kumitundu yosiyanasiyana yonyamula katundu,
• Mankhwala amathandiza kwambiri kuti magazi aziyenda bwino, ofunika kwambiri kwa shuga m'magazi,
• amathandizira pakuthandizira ziwiya zam'mimba, zomwe nthawi zambiri zimakhudzidwa ndi matenda a shuga.

Chifukwa cha zopindulitsa zomwe zimapangidwa ndimankhwala omwe amapezeka pa thupi, akatswiri azachipatala nthawi zambiri amalimbikitsa kutenga Mildronate a matenda ashuga.

Momwe mungamwere mankhwala

Ndikulimbikitsidwa kumwa mapiritsi kapena kupereka jakisoni m'mawa. Cholinga cha izi ndikuti chida ndicho chothandizira cha mantha amanjenje. Chifukwa chake, ngati mutenga Mildronate madzulo, mawonekedwe a kusowa tulo ndiwotheka.

Ndi zoletsedwa kugwiritsa ntchito Mildronate pochiza mtima pazinthu zotere:

• kuthamangitsidwa pamatumbo,
• ma neoplasms
• angapo matenda ovulala mu ubongo,
• tsankho la munthu pazinthu zina zomwe ndi gawo lamankhwala.

Ndikofunikira kumwa Mildronate mosamalitsa monga malangizo a dokotala, kutsatira mosamalitsa.

Kupanda kutero, zoterezi zimachitika:

• zotupa pakhungu,
• zovuta zam'mimba
• Edincke's edema,
• mawonekedwe a tachycardia,
• mwa anthu okalamba pali kuwonjezeka kwa kuthamanga kwa magazi.

Popeza mankhwalawa sanaphunziridwe kwathunthu, okhudza kudya kwa amayi apakati komanso munthawi yoyamwa, madokotala amamulembera pokhapokha ngati pali zoopsa. Ana samalimbikitsidwa kumwa mankhwalawa, chifukwa momwe thupi limakula silikutsimikiziridwa. Mtundu woyamba wa matenda ashuga, Mankhwala a Mildronate amawonetsedwa kwambiri.

Madokotala amalimbikitsa kuti odwala awo omwe akuvutika ndi kuchuluka kwa shuga m'magazi, atenge maphunziro a Mildronate. Kuchiza kumathandizira kukhalabe ndi mawonekedwe a mtima ndi mitsempha yamagazi. Kodi Mildronate wa matenda a shuga angatengedwe popanda kulandira mankhwala? Palibe chifukwa chomwe muyenera kudzilingalira. Mildronate iyenera kutengedwa pokhapokha pakulimbikitsidwa ndi dokotala.

Vidal: https://www.vidal.ru/d drug/mildronate__8897
Radar: https://grls.rosminzdrav.ru/Grls_View_v2.aspx?routingGu>

Mwapeza cholakwika? Sankhani ndikusindikiza Ctrl + Lowani

Mildronate - malangizo, ntchito, mtengo, ndemanga

Mildronate ndi mankhwala omwe amagwiritsidwa ntchito kuti achulukitse kagayidwe kazakudya komanso kusintha mphamvu ya minofu. Mankhwalawa amagwiritsidwa ntchito pazovuta zingapo komanso zofunikira za pathological. Gwiritsani ntchito mankhwalawa pokhapokha akutsimikizirani ndi dokotala, kutsatira mosamalitsa malangizo omwe mungagwiritse ntchito.

Mankhwalawa m'magulu apadziko lonse a ATX ali ndi code C01EV.

Mildronate ndi mankhwala omwe amagwiritsidwa ntchito kuti achulukitse kagayidwe kazakudya komanso kusintha mphamvu ya minofu.

Chofunikira chachikulu cha Mildronate chikuyimiriridwa ndi meldonium dihydrate. Kapangidwe ka ochulukirapo kumadalira mtundu wa kumasulidwa. Popanga yankho, madzi okonzekera amagwiritsidwa ntchito. Zophatikizira zothandizira za Mildronate, zomwe zimapezeka m'mapiritsi, zimaphatikizapo titanium dioxide, starch, gelatin, etc.

Kupanga kwa Mildronate mu mawonekedwe a piritsi sikuchitika.

Kutulutsidwa kwa Mildronate kumakhala ngati makapisozi. Ali ndi chipolopolo chokhala ndi khungu loyera. Pali ufa oyera mkati mwa kapisozi iliyonse. Ufa uwu umasungunuka kwambiri m'madzi.

Makapisozi a Mildronate amapezeka mu mlingo wa 250 mg ndi 500 mg. Makapisozi amadzaza matuza a ma PC 10.

Mbale ndi Mildronate zimadzaza mapaketi okhala ndi makatoni, momwe mumakhala malangizo ndi chidziwitso chokhudza mankhwalawo.

Njira yothetsera jakisoni imapezeka m'magalasi owonekera a 1 ml ndi 5 ml. Palibe mtundu. Ma jakisoni a Mildronate amaperekedwa kudzera mkati mwamitsempha. Njira yothetsera mankhwalawa imayikidwa mu ma meshes apulasitiki ndi makatoni.

Manyuchi amapezeka m'mabotolo amdima amdima a 100 mg ndi 250 mg. Bokosi lirilonse limakhala ndi katoni.

Njira yamachitidwe

The pharmacological zochita za Mildronate zimachitika chifukwa chakuti mankhwalawa amagwiritsidwa ntchito popanga mankhwalawa ndi analogue yopanga ya gamma-butyrobetaine yomwe ilipo mu khungu lililonse.
Kukhazikitsidwa kwa mankhwalawa kumatha kubwezeretsa bwino pakati pa zosowa zamaselo mu mpweya ndi kutumikiridwa kwa zinthu. Zimathandizira kuchotsa poizoni m'thupi la wodwalayo.

Kuphatikiza apo, zinthu zomwe zimagwiritsidwa ntchito Mildronate zimakupatsani mwayi wopewa kuwononga minofu yowonongeka. Ilinso ndi mphamvu yotchedwa antioxidant, yomwe imachulukitsa mphamvu ya thupi komanso imachepetsa chiwerengero cha ziwopsezo za angina. Pamaso pa madera a necrotic lesion, kugwiritsidwa ntchito ndikoyenera kuchepetsa kufalikira kwa foci ndikufupikitsa nthawi yobwezeretsa.

Zaumoyo Kuchotsera ulemu. Kodi kufatsa ndi chiyani? (03/27/2016)

Zotsatira zoyesedwa kuchipatala cha Mildronate®

PBC: Chifukwa chiyani ndipo ndani akufuna Mildronate-Meldonium?

Kodi mankhwalawa ndi ati?

Kugwiritsa ntchito kwa Mildronate kuli koyenera pamatenda osiyanasiyana. Jekeseni wa mankhwala amagwiritsidwa ntchito pang'onopang'ono hemophthalmia. Mankhwalawa nthawi zambiri amathandizidwa kuti athe kukha magazi chifukwa cha matendawo.

Kuphatikiza apo, pali chothandizanso pochotsa Mildronate ndi thrombosis ya mtsempha wapakati komanso nthambi zake zomwe zimakhala mu retina. Mphamvu zabwino zimawonedwa pambuyo pokhazikitsidwa kwa Mildronate mu diabetesic retinopathy.

Mankhwalawa amathandizira kuthetsa mtima wa minofu ya mtima komanso amachepetsa chiopsezo cha infaration ya pulayimale ndi yachiwiriyo. Kukhazikitsidwa kwa Mildronate kumakhala koyenera chifukwa cha kulephera kwa mtima ndi mtima.

Zisonyezo zakugwiritsa ntchito mankhwalawa ndi ngozi za m'magazi ndi mitsempha. Mildronate amathandizidwanso pakuchiza matenda obwera chifukwa cha uchidakwa. Mankhwala amagwiritsidwa ntchito chifukwa cha kutopa kwamatenda.

Kutenga?

Chifukwa cha zovuta zosangalatsa, mankhwalawa amayenera kumwa m'mawa. Pazovuta zamatenda a mtima, kugwiritsa ntchito Mildronate kumawonetsedwa ndi 0,5 mpaka 1 g patsiku.

Ngati vuto la cerebrovascular, mankhwalawa ndi mankhwala 0,5 mpaka 1 g tsiku lililonse. Njira ya chithandizo kuyambira 4 mpaka 6 milungu. Maphunziro obwerezedwanso amachitika katatu pachaka. Mu mtundu wa zakumwa zoledzeretsa, kukhazikitsidwa kwa Mildronate munjira ya mankhwala kumawonetsedwa ndi 0,5 g tsiku lililonse. Mankhwalawa amachitika kwa pafupifupi milungu iwiri.

Zotsatira zoyipa

Zotsatira zoyipa mukamamwa Mildronate ndizosowa. Chiwopsezo chitha kuchitika. Kwa anthu omwe ali ndi hypersensitivity pazigawo zamankhwala, angioedema ndizotheka. A mavuto chifukwa cha mankhwala akhoza kukhala dyspepsia, magazi mkhutu ndi tachycardia. Eosinophilia samachitika kawirikawiri.

Anthu omwe ali ndi hypersensitive pazigawo zamankhwala amatha kukumana ndi zovuta.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito Mildronate sikuletsedwa kuphatikiza ndi mankhwala omwe amagwiritsidwa ntchito kuti muchepetse magazi ndikuchepetsa chiopsezo cha magazi. Bronchodilators ndi okodzetsa angagwiritsidwe ntchito pochiza Mildronate. Kusamalidwa makamaka kuyenera kuchitika mukamagwiritsa ntchito Mildronate ndi Nitroglycerin. Kuphatikiza apo, chida ichi chimawonjezera mphamvu ya mtima glycosides.

Mankhwala omwe ali ndi vuto lofananalo amaphatikizapo:

Mankhwala Melfor ndi analogue a Mildonate.

Kutulutsa mafomu ndi kapangidwe kake

Chofunikira chachikulu cha Mildronate chikuyimiriridwa ndi meldonium dihydrate. Kapangidwe ka ochulukirapo kumadalira mtundu wa kumasulidwa. Popanga yankho, madzi okonzekera amagwiritsidwa ntchito. Zophatikizira zothandizira za Mildronate, zomwe zimapezeka m'mapiritsi, zimaphatikizapo titanium dioxide, starch, gelatin, etc.

Kupanga kwa Mildronate mu mawonekedwe a piritsi sikuchitika.

Kutulutsidwa kwa Mildronate kumakhala ngati makapisozi. Ali ndi chipolopolo chokhala ndi khungu loyera. Pali ufa oyera mkati mwa kapisozi iliyonse. Ufa uwu umasungunuka kwambiri m'madzi. Makapisozi a Mildronate amapezeka mu mlingo wa 250 mg ndi 500 mg. Makapisozi amadzaza matuza a ma PC 10. Mbale ndi Mildronate zimadzaza mapaketi okhala ndi makatoni, momwe mumakhala malangizo ndi chidziwitso chokhudza mankhwalawo.

Njira yothetsera jakisoni imapezeka m'magalasi owonekera a 1 ml ndi 5 ml. Palibe mtundu. Ma jakisoni a Mildronate amaperekedwa kudzera mkati komanso m'mitsempha. Njira yothetsera mankhwalawa imayikidwa mu ma meshes apulasitiki ndi makatoni.

Manyuchi amapezeka m'mabotolo amdima amdima a 100 mg ndi 250 mg.Bokosi lirilonse limakhala ndi katoni.