Momwe mungagwiritsire ntchito Metglib?

Zonse zokhudza matenda ashuga »Momwe mungagwiritsire ntchito Metglib Force?

Mphamvu ya Metglib imayimira othandizira a hypoglycemic. Chimalimbikitsa mayendedwe achilengedwe a shuga m'magazi. Ili ndi mphamvu yolimbikira. Ntchito kuchiza matenda a shuga 2.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi pamtengo wa 2,5 mg + 500 mg ndi 5 mg + 500 mg. Zofunikira zake ndi glibenclamide ndi metformin hydrochloride. Zinthu zotsalazo zimaperekedwa: wowuma, calcium dihydrate, komanso macrogol ndi povidone, ochepa cellulose.

Kanema wa mapiritsi oyera okhala ndi mapiritsi oyera 5 mg + 500 mg amapangidwa ndi Opadra yoyera, giprolose, talc, titanium dioxide. Mapiritsi ali ndi mzere wogawanitsa.

Mapiritsi 2.5 mg + 500 mg chowulungika, wokutidwa ndi filimu yoteteza ndi kuyanika ndi mtundu wa bulauni.

Zotsatira za pharmacological

Ndi othandizira a hypoglycemic, omwe ndi ochokera ku mibadwo iwiri, amapangidwira pakamwa. Imakhala ndi pancreatic komanso extrapancreatic zotsatira.

Glibenclamide imalimbikitsa kubisalira bwino kwa insulini pochepetsa kuzindikira kwake ndi maselo a beta mu kapamba. Chifukwa chakuwonjezeka kwambiri kwa insulin, imangiriza zigoli mwachangu. Njira ya lipolysis ya adipose minofu imachepetsa.

Mulingo wapamwamba kwambiri wa plasma umafikiridwa patatha maola 2 mutamwa. Hafu ya moyo wa glibenclamide imatenga nthawi yayitali kuposa metformin (pafupifupi maola 24).

Zizindikiro zogwiritsidwa ntchito

Zisonyezero zogwiritsidwa ntchito ndi izi:

• lembani matenda ashuga achikulire awiri, ngati zakudya ndi masewera olimbitsa thupi sizithandiza,
• kusowa kwa chithandizo chokwanira ndi mankhwala a sulfonylurea ndi metformin,
• m'malo monotherapy ndimankhwala 2 mwa anthu omwe ali ndi vuto labwino la glycemic.

Mankhwalawa amagwiritsidwa ntchito ngati mtundu wa shuga wachiwiri mwa akulu, ngati zakudya ndi zolimbitsa thupi sizithandiza.

Contraindication

Pali zotsutsana zingapo pakugwiritsa ntchito mankhwalawa zomwe zafotokozedwera mu malangizo. Zina mwa izo ndi:

• Hypersensitivity pamagawo a mankhwala,
• mtundu 1 shuga
• kuphwanya impso ntchito,
• matenda ashuga ketoacidosis,
• pachimake zinthu limodzi ndi minofu hypoxia,
• mimba ndi mkaka wa m`mawere
• matenda opatsirana
• kuvulala ndi ntchito zambiri,
• kugwiritsa ntchito miconazole,
• kuledzera
• lactic acidosis,
• kutsatira zakudya zochepa zama calori,
• ana ochepera zaka 18.

Ndi chisamaliro chachikulu, mankhwalawa amalembedwa kwa anthu omwe ali ndi vuto la chifuwa, uchidakwa, vuto la adrenal, gland gland ndi chithokomiro. Amalembedwanso mosamala kwa anthu azaka zapakati pa 45 ndi akulu (chifukwa cha kuchuluka kwa chiwopsezo cha hypoglycemia ndi lactic acidosis).

Momwe mungatenge Metglib Force?

Mapiritsiwo ndi a pakamwa pokha. Mlingo amasankhidwa payekha, poganizira kuuma kwa zovuta zowonekera zamankhwala.

Yambani piritsi limodzi patsiku ndi Mlingo wa yogwira wa 2,5 mg ndi 500 mg, motero. Pang'onopang'ono onjezani mlingo mlungu uliwonse, koma chifukwa cha zovuta za glycemia. Ndi mankhwala othandizira osinthira, makamaka ngati amachitika mosiyana ndi metformin ndi glibenclamide, tikulimbikitsidwa kumwa mapiritsi 2 patsiku. Mulingo wovomerezeka tsiku lililonse sayenera kupitirira mapiritsi 4 patsiku.

Zotsatira zoyipa

Pa mankhwala, kukula kwa zoyipa zimachitika:

• leuko- ndi thrombocytopenia,
• kuchepa magazi
• anaphylactic shock,
• achina,
• lactic acidosis,
• kuchepa mayamwidwe a vitamini B12,
• kulakwira
• kuchepa kwa masomphenya
• nseru
• kusanza
• kutsegula m'mimba
• kusowa kwa chakudya
• kumverera kolemetsa m'mimba
• chiwindi ntchito,
• yotupa chiwindi
• zimachitika pakhungu
• urticaria
• zidzolo limodzi ndi kuyabwa
• erythema
• dermatitis
• kuchuluka kwa kuchuluka kwa urea ndi creatinine m'magazi.

Anthu ayenera kudziwitsidwa za chiwopsezo cha hypoglycemia ndikuchita izi popewa asanafike kumbuyo kwa galimoto kapena kuyamba kugwira ntchito ndi njira zovuta zomwe zimafunikira chidwi chachikulu.

Malangizo apadera

Mankhwalawa amathetsedwa pochiza zowopsa, matenda opatsirana, chithandizo chovuta kwambiri asanachitike maopaleshoni akuluakulu. Zikatero, amasinthana ndi insulin yokhazikika. Chiwopsezo cha kukhala ndi hypoglycemia chimawonjezeka ndimatenda m'zakudya, kusala kudya nthawi yayitali komanso ma NSAID.

Zosaloledwa. The yogwira thunthu limadutsa chotchinga chotchinga cha placenta ndipo imatha kusokoneza mochita kupanga ziwalo.

Simungathe kumwa mapiritsi panthawi yotsekera, chifukwa zinthu zodutsa zimapita mkaka wa m'mawere. Ngati chithandizo chikufunika, ndi bwino kusiya kuyamwitsa.

Zosagwiritsidwa ntchito mwa ana.

Amuna ndi akazi oposa 65 ayenera kusamala, monga mwa anthu otere, chiopsezo chokhala ndi hypoglycemia chimalimbikitsidwa kwambiri.

Kuthekera kwa kugwiritsidwa ntchito kumakhudzidwa ndi chilolezo cha creatinine. Mukakhala kuti ndi wamkulu, ndi mankhwala ochepa omwe amakupatsani. Ngati wodwalayo akuipiraipira, ndibwino kukana chithandizo chotere.

Kulandilidwa ndikosavomerezeka ngati kupezeka kuti chiwindi chikulephera. Izi zimadziunjikira zomwe zimagwira m'chiwindi ndikuthandizira kuwonongeka kwa mayeso a chiwindi.

Bongo

Ndi mankhwala osokoneza bongo, hypoglycemia imachitika. Digiri yofatsa imatha kuwongoleredwa ndi kugwiritsa ntchito shuga kapena zakudya zopatsa mphamvu. Mungafunike mlingo kapena kusintha kwa zakudya.

Milandu yayikulu ikaperekedwa ndi matenda osazindikira, wodwala kapena wodwala matenda ashuga, amathandizira yankho la shuga kapena glucagon wa intramus. Pambuyo pa izi, ndikofunikira kudyetsa munthu chakudya chamafuta ambiri othamanga.

Odwala omwe ali ndi kuwonongeka kwa hepatic, kutsimikizika kwa glibenclamide kumawonjezeka. Mankhwalawa sachotsedwa ndi dialysis, chifukwa glibenclamide imamangiriza bwino mapuloteni amwazi.

Mankhwala osokoneza bongo amathandizidwa pokhapokha pachipatala, akafika lactic acidosis. Chothandiza kwambiri pamenepa ndi hemodialysis.

Kuchita ndi mankhwala ena

Kugwiritsa ntchito pamodzi kwa miconazole, fluconazole kumawonjezera mwayi wa hypoglycemia. Phenylbutazone amasiya kumangika kwa zinthu zomwe zimapangidwa ndi mapuloteni, zomwe zimatsogolera ku hypoglycemia ndi kuchuluka kwawo mu seramu yamagazi.

Mankhwala okhala ndi ayodini omwe amagwiritsidwa ntchito pakuwunika kwa X-ray nthawi zambiri amasokoneza ntchito ya impso komanso kuchepa kwa metformin. Izi zimakwiyitsa kupezeka kwa lactic acidosis.

Ethanol imayambitsa zochitika zosasangalatsa. Ma diuretics amachepetsa mphamvu ya zotsatira za mankhwala. ACE zoletsa ndi beta-blockers amatsogolera mkhalidwe wa hypoglycemic.

Osamamwa mapiritsi ndi mowa. Izi zimayambitsa hypoglycemia yayikulu, imachulukitsa zotsatira zina zoyipa.

Pali mndandanda wofanizira wa mankhwalawa, wofanana ndi iwo pazinthu zomwe zikugwira ntchito:

• Bagomet Plus,
• Glibenfage
• Glibomet,
• Glucovans,
• Gluconorm,
• Gluconorm Plus,
• Metglib.

Ndemanga za Metglib Force

Moroz V. A., wazaka 38, endocrinologist, Arkhangelsk: "Mankhwalawa ndi othandiza. Tsopano ndimayesetsa kumusankha nthawi zambiri. Shuga amapangitsa odwala matenda ashuga kukhala bwino, palibe zotsatira zoyipa. ”

Kozerod A.I., wazaka 50, endocrinologist, Novosibirsk: "Ndimakonda mankhwalawa, amavomerezedwa ndi odwala. Ndimapereka mankhwala nthawi zambiri, koma ndisanapume nthawi ndiyenera kudziwa komwe amapezeka. ”

Veronika, wazaka 32, ku Moscow: “Mayi anga akhala akudwala matenda a shuga kwa nthawi yayitali. Poyamba adathandizidwa ndi Glybomet. Koma zikafunika kuwonjezera mlingo, zimakhala zodula kwambiri. Glibomet inasinthidwa ndi Metglib Force, yomwe ndiyotsika mtengo. Mankhwalawa amagwira ntchito yabwino kwambiri, ngakhale kuphwanya zakudya. Shuga amasungidwa pamlingo womwe hypoglycemia sinakhale kwa nthawi yayitali. Zokhazo zokhazokha ndikuti ndizovuta kupeza m'masitolo. ”

Roman, wazaka 49, Yaroslavl: “shuga yanga itakwana 30 ndipo ndimapita kuchipatala mosayembekezereka, anandipeza ndi matenda a shuga. Adayamba mankhwala a insulin. Kenako ndidayamba kudabwa ndi adotolo ngati zingatheke kusintha ma jakisoni kupita pamapiritsi. Adotolo adalimbikitsa kuyesa mapiritsi a Metglib Force. Ndakhala ndikugwiritsa ntchito kwa zaka ziwiri, ndakhuta. Shuga amasungidwa nthawi zonse, sipanakhalepo nthawi yayitali. ”

Valeria, wazaka 51, Chelyabinsk: “Ndinamwa pafupifupi chaka chimodzi. Shuga anali wabwinobwino, kunalibe hypoglycemia, koma ndinamva kusowa, panali nseru nthawi zonse. Zinapezeka kuti ndinali ndi vuto la chithokomiro. Tsopano timasankha chithandizo choyenera. Adotolo adasiya mapiritsi a Metglib Force. Akuyenda bwino. ”

Pharmacological zimatha mankhwala Glibomet

Mankhwala Glibomet ndi kuphatikiza kwa glibenclamide ndi metformin. Kuphatikizika kwa magawo awiriwa ndikuti pali kukondoweza kwazobisika zamatumbo amkati omwe amayamba chifukwa cha glibenclamide, komanso kuwonjezeka kwakukulu pakugwiritsa ntchito shuga ndi minofu minofu chifukwa cha metformin. Izi zimabweretsa gawo lalikulu la synergistic, lomwe limalola kuchepetsa kuchuluka kwa gawo lililonse la mankhwalawa, motero kuchepetsa kukondweretsedwa kwakukulu kwa maselo a pancreatic β ndi chiwopsezo chokhala ndi kusakwanira kwa magwiridwe antchito, kumachepetsa kwambiri mavuto.
Pharmacokinetics Pafupifupi 84% ya glibenclamide imalowetsedwa m'mimba. Zimapukusidwa mu chiwindi ndikupanga ma metabolites osagwira, omwe amaponyedwa ndowe ndi mkodzo. Hafu ya moyo ndi maola 5. Kuchuluka kwa mapuloteni a plasma ndi 97%.
Metformin, yophatikizidwa mu chakudya cham'mimba, imatulutsidwa mwachangu m'zimbudzi ndi mkodzo, siziwoneka m'mapuloteni a plasma, ndipo siipangidwira thupi. Kuchotsa theka-moyo pafupifupi 2 maola.

Kugwiritsa ntchito mankhwala Glibomet

Mlingo wa tsiku ndi tsiku komanso nthawi yake ya mankhwalawa imatsimikiziridwa payekha ndi dokotala malinga ndi momwe wodwalayo alili. Mlingo woyamba wa akulu nthawi zambiri mapiritsi 2 patsiku (piritsi limodzi m'mawa ndi madzulo ndi chakudya), tsiku lililonse mankhwalawa sayenera kupitilira mapiritsi 6 (mapiritsi 2 katatu patsiku ndi chakudya). Gawani osachepera ogwira mlingo, kupereka yoyenera kuchuluka kwa glycemia. Mlingo wa tsiku ndi tsiku pakapita nthawi umatha kuchepetsedwa pang'onopang'ono mpaka mlingo wochepa wolamulira shuga m'magazi ufike.

Zotsatira zoyipa za mankhwala Glibomet

Nthawi zina, kukula kwa hypoglycemia ndikotheka, makamaka kwa odwala omwe ali ndi matendawa, okalamba, ndi masewera olimbitsa thupi osazolowereka, kudya kosakhazikika kapena kumwa mowa, vuto la chiwindi ndi / kapena impso. Nthawi zina pamakhala kupweteka kwam'mutu, matenda am'mimba: nseru, anorexia, gastralgia, kusanza, kutsekula m'mimba, kumafuna kusiya ntchito. Nthawi zina, thupi limakumana ndi vuto, nthawi zambiri limakhalapo kwakanthawi ndipo limatha lokha ndi chithandizo chanthawi zonse. Milandu yomwe ikufotokozedwa m'mabuku a chitukuko cha metabolic acidosis pa nthawi ya mankhwala a metformin ndiyosowa. Komabe, zadziwika kuti odwala omwe ali pachiwopsezo, monga aimpso komanso amtima amalephera, izi zitha kutenga nthawi yayitali ngati chithandizo ndi mankhwalawo sichiyimitsidwa nthawi yomweyo ndipo njira zoyenera za mankhwala sizingatenge. Milandu yowonjezereka pamlingo wa lactic acid mu seramu yamagazi, kuwonjezeka kwa kuchuluka kwa lactate / pyruvate, kuchepa kwa magazi pH ndi hyperazotemia kwatchulidwa (milandu yonseyi imafotokozedwa kwa odwala omwe ali ndi vuto losavomerezeka la matenda ashuga). Kukula kwa metabolic acidosis kungayambitse kugwiritsa ntchito nthawi yomweyo mowa pamankhwala. Hematopoiesis ndi osowa kwambiri ndipo nthawi zambiri amasintha.

Zochita zamankhwala Glibomet

Mphamvu ya gloglycemic ya glibenclamide imatha kupezeka ndi dicumarol ndi zotumphukira zake, ma inhibitors a MAO, mankhwala a sulfonamide, phenylbutazone ndi zotumphukira zake, chloramphenicol, cyclophosphamide, probenecid, pheniramine, salicylates, miconazole kwa zakumwa zamkamwa, sortinpyr. Mphamvu ya glibenclamide imatha kufooka ndi kugwiritsa ntchito nthawi imodzi ya epinephrine, corticosteroids, kulera kwapakamwa, thiazide diuretics ndi barbiturates. Chenjezo liyenera kugwiritsidwa ntchito mukamagwiritsa ntchito β-adrenergic receptors ndi blockers. Tiyenera kukumbukira kuti biguanides imatha kupititsa patsogolo zotsatira za anticoagulants.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mankhwala amatengedwa pakamwa, ndi zakudya. Malamulo a Metglib mlingo amasankhidwa payekha, kutengera mtundu wa kagayidwe.

Nthawi zambiri, mlingo woyambirira wa Metglib ndi piritsi limodzi (2,5 mg glibenclamide ndi 500 mg metformin), ndikusankha pang'onopang'ono masabata onse a 1-2, kutengera mtundu wa glycemic.

Posintha njira yothandizira yophatikizira ndi metformin ndi glibenclamide (monga zigawo zina), mapiritsi a 1-2 (2,5 mg glibenclamide ndi 500 mg metformin) amawayikira, kutengera muyeso wa gawo lililonse la chinthu chilichonse.

Mlingo wambiri watsiku ndi tsiku ndi mapiritsi 4 (2,5 kapena 5 mg a glibenclamide ndi 500 mg ya metformin).

Kutulutsa mawonekedwe ndi kapangidwe kake

Wopezeka mu mawonekedwe a mapiritsi a biconvex ozungulira wopota ndi chipolopolo choyera. Mapiritsi amadzaza matuza a 20 zidutswa. Amagulitsidwa mumathumba okhala ndi matuza a 2, 3 kapena 5.

Malangizo a Glibomet (njira ndi Mlingo)

Dokotalayo amakhazikitsa dongosolo la mankhwalawa komanso kutalika kwa njira ya chithandizo payekhapayekha, kutengera kuchuluka kwa shuga m'magazi komanso mkhalidwe wa chakudya.

Mlingo woyambirira uyenera kukhala mapiritsi atatu patsiku, ndikutsatira pang'ono panjira.

Tengani kawiri patsiku chakudya cham'mawa komanso chamadzulo. Mlingo wa tsiku lililonse malinga ndi malangizo sayenera kupitilira mapiritsi 6.

Kuyanjana kwa mankhwala

• Hypoglycemic zotsatira za mankhwalawa zimatha kuwonjezereka pomwe zimamwa ndi dicumarol ndi zotumphukira zake, ma beta-blockers, cimetidine, oxytetracycline, sulfanilamides, allopurinol, mao inhibitors, phenylbutazone ndi zotumphukira zake, phenenecid, chloramphenicol, salicylinone zochuluka.
• Zotsatira zamankhwala zimatha kuchepa limodzi ndi ma epinephrine, mahomoni a chithokomiro, glucocorticoids, barbiturates, thiazide diuretics komanso njira yolerera pakamwa.
• Ndi munthawi yomweyo kugwiritsa ntchito mankhwalawa ndi anticoagulants, kuwonjezeka kwamphamvu yotsirizira ndikotheka.
• Mukamamwa ndi cimetidine, chiopsezo chokhala ndi lactic acidosis imachuluka.

Mtengo mumafakisi

Price Glibomet ya phukusi limodzi imayamba kuchokera ku ma ruble 280.

Malongosoledwe patsamba lino ndi mtundu wosavuta wa mtundu wazovomerezeka zamankhwala. Chidziwitsochi chimaperekedwa kuti chizidziwitso chokha komanso sikuti chitsogozo chodzidzipangira nokha.Musanagwiritse ntchito mankhwalawa, muyenera kufunsa katswiri kuti mudziwe malangizo omwe amavomerezedwa ndi wopanga.