Flemoklav Solutab 875

Ana Flemoklav Solutab 125 + 31.25 mg - mankhwala ochokera pagulu la penicillin omwe ali ndi zochita zambiri. Kuphatikiza kophatikizira kwa amoxicillin ndi clavulanic acid, choletsa-lactamase inhibitor.

Piritsi limodzi la 125 + 31.25 mg lili:

• Zogwira pophika: amoxicillin trihydrate (yomwe imagwirizana ndi amoxicillin base) - 145.7 mg (125 mg), potaziyamu clavulanate (yomwe imafanana ndi clavulanic acid) - 37.2 mg (31.25 mg).
• Omwe amathandizira: cellcrystalline cellulose - 81.8 mg, crospovidone - 25.0 mg, vanillin - 0,25 mg, kukoma kwa apricot - 2.25 mg, saccharin - 2.25 mg, magnesium stearate - 1.25 mg.

Mapiritsiwa amakhala amtunduwu kuyambira oyera mpaka achikasu okhala ndi mawanga amtundu wa bulauni popanda zoopsa ndipo amalembedwa "421" - pa mlingo wa 125 mg + 31.25 mg.

Kugawa

Pafupifupi 25% ya clavulanic acid ndi 18% ya plasma amoxicillin amagwirizanitsidwa ndi mapuloteni a plasma. Kuchuluka kwa kufalitsa amoxicillin ndi 0,3 - 0,4 l / kg ndipo kuchuluka kwa magawidwe a clavulanic acid ndi 0,2 l / kg.

Pambuyo pokonzekera intravenous, amoxicillin ndi clavulanic acid amapezeka mu ndulu ya ndulu, m'mimba, pakhungu, mafuta ndi minofu minofu, mu madzi amwano ndi a peritoneal, komanso mu bile. Amoxicillin imapezeka mkaka wa m'mawere.

Amoxicillin ndi clavulanic acid amawoloka placental zotchinga.

Biotransformation

Amoxicillin amapakidwa pang'ono limodzi ndi mkodzo mu mawonekedwe a penicilloid acid, mu 10-25% yoyamba ya mankhwala. Clavulanic acid imapangidwa mu chiwindi ndi impso (zowonjezera mu mkodzo ndi ndowe), komanso mpweya wa kaboni ndi mpweya wotayika.

Hafu ya moyo wa amoxicillin ndi clavulanic acid kuchokera ku seramu yamagazi mwa odwala omwe ali ndi vuto lofanana ndi aimpso pafupifupi ola limodzi (0,9-1.2 maola), mwa odwala omwe ali ndi chilolezo cha creatinine mkati mwa 10-30 ml / mphindi ndi maola 6, ndipo kwa anuria amasiyanasiyana. pakati pa 10 ndi 15 maola. Mankhwala amachotsedwa pa hemodialysis.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amachotsedwa osasinthika ndi mkodzo m'maola 6 oyamba.

Zizindikiro zogwiritsidwa ntchito

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

• Matenda opumira kwambiri a m'mapapo (kuphatikizapo matenda a ENT), mwachitsanzo.
• Matenda ochepetsa kupuma am'mimba, monga kufalikira kwa chifuwa cham'mimba, chibayo, ndi bronchopneumonia, omwe amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus fuluwenza, ndi Moraxella catarrhalis.
• Matenda a urogenital thirakiti, mwachitsanzo, cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli), Staphylococcus saprophyticus ndi mitundu ya genus Enterococcus, komanso gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae.
• Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, Streptococcus pyogene, ndi mitundu ya mtundu wa Bacteroides.
• Kutupa kwa mafupa ndi mafupa, mwachitsanzo, osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, ngati pakufunika kutero, chithandizo cha nthawi yayitali ndizotheka.
• Matenda a Odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, zotupa zamano kwambiri ndi kufalitsa kwa cellulitis.

Matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake, intra-m'mimba sepsis) monga gawo la njira yothandizira.

Matenda oyambitsidwa ndi tizilombo tating'onoting'ono ta amoxicillin amatha kuthandizidwa ndi Flemoklav Solutab, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Flemoklav Solutab amasonyezedwanso ntchito yochizira matenda osakanikirana oyambitsidwa ndi tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa beta-lactamase, tcheru ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Contraindication

Flemoklav Solutab 125 mapiritsi + 31.25 mg ali ndi zotsutsana zotsatirazi:

• Hypersensitivity kwa amoxicillin, clavulanic acid ndi zinthu zina za mankhwalawo, komanso mankhwala ena a beta-lactam (penicillins ndi cephalosporins) mu anamnesis,
• Mbiri yakale ya jaundice kapena chiwindi kulephera chifukwa cha amoxicillin / clavulanic acid,
• Ana okalamba mpaka chaka chimodzi kapena zolemera thupi mpaka 10 makilogalamu (chifukwa cha kuthekera kwa dosing fomu yokhala mu gulu ili la odwala).

Mosamala kwambiri, mankhwalawa pazotsatira zotsatirazi:

• Kulephera kwamphamvu kwa chiwindi,
• matenda am'mimba (kuphatikizapo mbiri ya colitis yokhudzana ndi kugwiritsidwa ntchito kwa penicillin),
• aakulu aimpso kulephera.

Mlingo ndi makonzedwe

Mapiritsi a Flemoklav Solutab a 125 + 31.25 mg amatengedwa pakamwa. Mwa ana osakwana zaka 6, ndikofunikira kugwiritsa ntchito mankhwalawa mawonekedwe osungunuka.

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa. Kuti muchepetse kusokonezeka kwa m'mimba ndikuwonjezera kuyamwa, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya. Piritsi limamezedwa lonse, kutsukidwa ndi kapu ya madzi, kapena kusungunuka ndi theka kapu yamadzi (osachepera 30 ml), kuyambitsa bwino musanagwiritse ntchito. Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda. Ngati ndi kotheka, ndikotheka kuchitapo kanthu mankhwala oyambira (makolo oyamba a amoxicillin + clavulanic acid, otsatiridwa ndi makonzedwe apakamwa).

Akuluakulu ndi ana osaposa zaka 12 okhala ndi kulemera kwa thupi ≥ 40 kg Mankhwala ndi 500 mg / 125 mg katatu / tsiku.

Mlingo wapamwamba wa tsiku lililonse sayenera kupitirira 2400 mg / 600 mg patsiku.

Ana a zaka 1 mpaka zaka 12 ndi thupi lolemera 10 mpaka 40 kg Mlingo wa mankhwalawa umakhazikitsidwa payekhapayekha potengera matenda komanso kuopsa kwa matendawa.

Mlingo wovomerezeka tsiku lililonse umachokera pa 20 mg / 5 mg / kg patsiku mpaka 60 mg / 15 mg / kg patsiku ndipo umagawidwa pawiri kapena katatu.

Zotsatira zamankhwala pazogwiritsira ntchito amoxicillin / clavulanic acid pazowerengeka 4: 1 pa Mlingo> 40 mg / 10 mg / kg patsiku la ana osakwana zaka ziwiri. Mlingo wapamwamba wa tsiku lililonse wa ana ndi 60 mg / 15 mg / kg patsiku.

Mlingo wochepa wa mankhwalawa amalimbikitsidwa pochizira matenda amkhungu ndi minyewa yofewa, komanso matendawa omwe amapezeka, mapiritsi a mankhwalawa amalimbikitsidwa pochiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma kwamatenda ndi kwamikodzo matenda a mafupa ndi mafupa. Palibe zambiri zachipatala zomwe zingapangitse kuti mankhwalawa agwiritsidwe ntchito mopitilira 40 mg / 10 mg / kg / tsiku mu 3-mgawo wogawika (4: 1) mwa ana osakwana zaka ziwiri.

Njira yolondola ya odwala omwe ali ndi ana yaperekedwa patebulo pansipa:

Zambiri

Malangizo omwe aphatikizidwa pamaphukusi aliwonse a Flemoklav Solyutab 875/125 amadziwitsa kuti amapangidwa ndi kampani yaku Dutch yomwe imadziwika mumsika wama Russia ndikupanga Astellas Pharma Europe B.V.

Mankhwalawa ndi antibayotiki omwe ali ndi mawonekedwe owonjezereka ochita zinthu. Imapezeka m'makatoni oikidwa. Paketi iliyonse ili ndi matuza awiri okha. Iliyonse mwa mapiritsi 7wo amakhala ndi maselo okhala ndi mpweya. Ndiwakulu kukula, obala, kufota, alibe chiopsezo chogawanitsa (ndiye kuti magawikidwe azigawo sanaperekedwe). Ali ndi logo ya kampani ndi manambala "424". Chidziwitso ichi chikuthandizani kusiyanitsa zachilengedwe ndi zabodza.

Utoto wa mapiritsi achi Dutch uyenera kukhala woyera kapena wowala wachikasu wokhala ndi mawanga bulauni. Makonda awo ndi achindunji, monga akunenedwa ndi onse omwe amayankha ndemanga zawo. Pofuna kumvetsetsa bwino chithunzichi, tikuonetsa zithunzi zingapo za Flemoklav Solyutab 875/125. Malangizirowa amatsimikizira mapiritsi ngati kuti ameza, kutsukidwa ndi madzi, kapena kusungunuka ndi madzi (100-150 ml) ndikumwa mu mawonekedwe a kuyimitsidwa komwe adalandira chifukwa kukonzekera kuli m'gulu la mankhwala omwazika.

Tatiyeni tifotokoze tanthauzo la tanthauzo lachipatalachi. Mapiritsi okhala ndi mankhwala omwe sayenera kuwameza ndi madzi. Amatha kusungunuka mkamwa, ndipo amathanso kusungunuka m'madzi ndikupanga mankhwalawo kuti awoneke ngati kuyimitsidwa. Piritsi yamtunduwu imapangidwira odwala omwe ali ndi dysphagia (omwe ali ndi vuto la kumeza), komanso kwa aliyense amene ali ndi vuto lililonse ndi mankhwalawa.

Chifukwa chake, kukoma kwa mankhwalawa ndikofunikira kwambiri. Flemoklav Solyutab amapangidwa m'mitundu iwiri. Kuti mukhale wolondola kwambiri, ndimalandiro a mandimu ndi malalanje. Ngati kununkhira kwa mapiritsi sikukuyenererani ndipo kumayambitsa kusanza mukamawagwiritsa ntchito ngati kuyimitsidwa, amaloledwa kuwonjezera uchi kapena shuga njira yothetsera kukoma. Amaloledwanso kumwa mankhwalawa ndi chinthu chilichonse chomwe mungafune (mwachitsanzo, ndikwapulidwa ndi zipatso mu blender.

Mutha kugula mankhwalawo ku pharmacy iliyonse. Amamasulidwa kokha pamankhwala. Pogula mankhwalawa, chisamaliro chapadera chiyenera kulipidwa manambala otsatira dzina la mankhwalawo ndipo nthawi zonse amawonetsedwa pa phukusi. Chowonadi ndi chakuti "Flemoklav Solyutab" kampani yaku Dutch imatulutsa m'njira zingapo.

Chifukwa chake, pali mapiritsi a mankhwalawa omwe ali ndi Mlingo wa amoxicillin ndikuwathandizira kuti awononge mabakiteriya a clavulanic acid motere: 500/125, 250 / 62.5 ndi 125 / 31.25. Onsewa ali ndi katundu wofanana wochiritsa. Koma ngati phukusi lokhala ndi kuchuluka kwa mankhwala othandizira likugulidwa, dokotala amayenera kusintha kuchuluka kwa mankhwalawo.

Mankhwala omwe amakhala ndi zinthu zofunika kwambiri za 875/125 amatengera 380 mpaka 490 ma ruble, zomwe zimatengera mmbali mwa malo ogulitsa mankhwala opezeka ndi mayendedwe ndi zina.

Kupanga kwamankhwala

Malangizo omwe adapereka ku Flemoklav Solutab 875/125 akuwonetsa kuti pali zinthu ziwiri zokha zomwe zimatsutsana ndi mabakiteriya pokonzekera:

1. Amoxicillin. Piritsi lililonse lili ndi 875 mg.
2. Clavulanic acid: 125 mg m'mapiritsi.

Manambala omwe ali phukusi la "875" ndi "125" akuwonetsa ndendende zomwe zili pazinthuzi pokonzekera. Kuphatikiza apo, piritsi lililonse lili ndi:

• vanillin (1 mg),
• magnesium stearate (5 mg),
• saccharin (9 mg),
• crospovidone (100 mg)
• ma cell aprosropropous 327 mg,
• kununkhira kwa apurikoti.

Malangizo a Flemoklav Solyutab 875/125 sapereka chofotokozera chilichonse. Timadzaza izi kuti odwala athe kudziwa zomwe zimalowa mthupi lawo ndi piritsi lililonse la mankhwalawo.

Amoxicillin

Izi ndi mankhwala ochokera ku gulu la penicillin. Ndi gawo lachitatu laling'ono, lotchedwa aminopenicillins, ndipo ndilophatikizira zovuta, kuphatikiza pakupanga penicillin, zinthu monga ticarcillin ndi carbenicillin. Izi zikulongosola mitundu yaying'ono yosiyanasiyana yachilengedwe yomwe amatha kumenya nayo.

Chomwe akuchita ndikuwononga makoma a mabakiteriya poletsa kapangidwe kazomwe zimapangira - peptidoglycan.

Malinga ndi malangizo a "Flemoklav Solyutab" 875/125, pakupanga mapiritsi, amoxicillin amakhala patsogolo. Tiyenera kukumbukira kuti ngakhale mankhwalawa amagwiritsidwa ntchito kwambiri motsutsana ndi tizilombo tating'onoting'ono ndipo alibe vuto lililonse kwa anthu ambiri, amathanso kuyambitsa mavuto ena mwa odwala: zotupa, zotupa za m'mimba, kutentha thupi mpaka 38 ° C, kupweteka kwam'mimba, kugaya m'mimba, ngakhale kowopsa. osati kokha thanzi komanso moyo anaphylactic. Nthawi zina, odwala amakumana ndi kusanza, kupindika komanso chizungulire.

Tiyeneranso kudziwa kuti mankhwala amphamvu ngati amoxicillin, omwe amagwiritsidwa ntchito kwa nthawi yayitali, sangawononge mabakiteriya okhala ndi tizilombo komanso komanso opindulitsa omwe amakhala ndi mucous membrane. Izi zimasokoneza mawonekedwe abwinobwino a microflora, zimapatsa minofu ndikukwaniritsidwa kwa ntchito zawo. Izi zimatha kupangitsa kuti pakhale dysbiosis, ndipo mwa akazi kuwonjezera mawonekedwe a matenda monga bacvinosis ndi vagidi candidiasis.

Clavulanic acid

Monga malangizo "Flemoklava Solutab" 875/125 amatidziwitsa, pakupanga mankhwala pafupifupi gawo 1/5 ndi clavulanic acid. Izi ndi zoletsa za michere ya beta-lactamase. Amapangidwa ndi mabakiteriya ambiri kuti atsimikizire kuti kukana kwa antiotic. Poletsa ntchito za michereyi, clavulanic acid imachepetsa kukana kwa ma virus komanso imathandizira ntchito yotsutsana ndi ma antimicrobial. Kuphatikiza apo, gawo ili likutha kuwononga mitundu ina ya mabakiteriya: streptococci, chlamydia, staphylococci, genococci, legionella. Mukaphatikizidwa, clavulanic acid ndi amoxicillin amagwira ntchito motsutsana ndi mabakiteriya monga:

• streptococci (viridians, pyogene, anthracis, chibayo),
• staphylococci (aureus, epidermidis),
• enterococci,
• corynebacteria,
• clostridiums
• peptococci,
• peptostreptococcus,
• Shigella
• Bordetella
• gardnerella,
• Klebsiella
• nsomba
• Escherichia
• mapuloteni
• Helicobacter pylori.

Izi zikuwonetsedwa pamalangizo "Flemoklava Solyutab" 875/125. Komabe, sizikuwonetsedwa pamenepo kuti kuchita pamodzi, amoxicillin ndi clavulanic acid omwe amagwiritsidwa ntchito ndi iwo kumayambitsa intracellular bactericidal zochita za leukocytes, amathandizira awo chemotaxis (kuyenda komwe kumachokera chilondacho) ndi leukocyte adhesion (cell adhesion). Zonsezi zimawonjezera mphamvu ya mankhwalawa. Makamaka zinthu zofunikirazi zimawonekera pothandizira matenda opumira omwe amayamba chifukwa cha bacterium pneumococcus.

Zowonjezera zina za mankhwala

Crospovidone. Katunduyu ku Russia amatchedwa povidone. Ndi gawo la gulu la enterosorbents. Malo ake ndi kusinthasintha. Ndiye kuti, povidone imamangirira poizoni: zonse zimachokera kunja, ndipo zimapangidwa munthawi zosiyanasiyana mthupi. Simalowa m'magazi, amangogwira ntchito m'mimba. Nthawi yomweyo, sichikuphwanya nembanemba, simadziunjikira mumaselo, ndikuchotseredwa ndowe.

Povidone adayambitsidwa m'mapiritsi a Flemoklava Solutab ku poizoni wa adsorb wobisika wa pathogenic, komanso kuchotsa zinthu zina zoyipa kuchokera kuzomwe zimapangidwa ndi metabolic, potero kusintha kusintha kwamphamvu kwa zigawo zikuluzikulu za mankhwala.

Komabe, nthawi zina, povidone imachepetsa kuyamwa kwa mankhwala. Kuti izi zisachitike mukamamwa mankhwalawo, kuchuluka kwake kumatsimikiziridwa bwino. Povidone ilibe zotsutsana, koma nthawi zina zimayambitsa nseru komanso kusanza.

Ma cellulose opatsa chidwi kwambiri. Malinga ndi malangizo a Flemoklav Solutab 875/125, piritsi ili pafupifupi katatu kuposa crospovidone. Ma Microporous cellulose ndi polysaccharide, samayamwa, osafunikira, samayambitsa mavuto. Kamodzi m'matumbo am'mimba, imakhala ngati chinkhupule, chimatenga zinthu zapathupi, ndiko kuti, imagwira ntchito ngati sorbent.

Magnesium wakuba. Kugwiritsidwa ntchito ngati filler ndi yakale.

Zina zotsalira za mankhwalawa zimapatsa matendawa mphamvu zake.

Gawo la ntchito

Monga momwe malangizirowa akufotokozera, mankhwalawa "Flemoklav Solutab" 875/125 ndi othandiza pa matenda otsatirawa:

• matenda oyamba ndi kupuma (chibayo, bronchitis, zotupa zam'mapapo),
• matenda a ziwalo za ENT (atitis media, pharyngitis, sinusitis, tonsillitis),
• matenda a pakhungu (erysipelas, dermatoses, impetigo, matenda a bala, phlegmon, abscesses),
• osteomyelitis
• matenda a kwamikodzo ndi kubereka (cystitis, pyelitis, cervicitis, pyelonephritis, salpingitis, prostatitis, urethritis),
• matenda opatsirana pogonana (chinzonono, chancre),
• zovuta mu ma contretrics ndi opaleshoni (pambuyo pa sepsis, matenda pambuyo pa opaleshoni, kuchotsa septic).

Pharmacokinetics

Pofotokozera za mankhwalawa "Flemoklav Solutab" 875/125, malangizowa akuti, kamodzi m'mimba, clavulanic acid ndi yankho lalikulu la mankhwalawa limalowa m'magazi mosavuta. Pankhaniyi, kuchuluka kwa plasma kwa amoxicillin ndi maola 1.5 (12 μg / ml). Mafuta ake ndi 90% (akatengedwa pakamwa). Pafupifupi 20% ya zinthu zotere zimamangiriza mapuloteni omwe amapezeka m'madzi a m'magazi.

Zinayesedwa motsimikiza kuti hafu ya moyo wa chinthu monga amoxicillin ndi maola 1.1. Imafufutidwa ndi impso mu mawonekedwe osasinthika, ndipo pafupifupi 80% imachotsedwa m'thupi mkati mwa maola 6 (okwera 6.5) atatha kumwa.

Kwa clavulanic acid, nthawi yofika ndende yozama kwambiri ya 3 μg / ml ndi 1 ora. Pafupifupi 60% imalowa m'mimba, ndipo pafupifupi 22% imamangidwa ndi mapuloteni a plasma. Mu thupi la munthu, chinthu ichi chimapangidwa ndi hydrolysis ndi kusintha kwa decarboxylation. Ndiye kuti, akuwonetsedwa kale mu mawonekedwe osinthidwa. Kuphatikiza apo, m'maola oyamba 6,6,5, pafupifupi 50% imachotsedwa m'thupi.

Mlingo ndi malamulo oyendetsera

Ganizirani momwe mungatengere "Flemoklav Solutab" 875/125. Malangizo ndi njira za kayendetsedwe ka ntchito zikuwonetsa izi:

1. Kwa ana a zaka 12, amaloledwa kumwa piritsi limodzi m'mawa komanso piritsi limodzi 1 madzulo. Nthawi yanji sikofunikira kwambiri kuchita izi. Chachikulu ndikuti maola osachepera 12 amatha pakati pama phwando. M'mawunikidwe, odwala ambiri amawonetsa kuti amamwa mankhwalawa nthawi ya 8 m'mawa komanso 8 madzulo.
2. Ana omwe ali ndi zaka zosakwana 12, koma akulemera makilogalamu 40 kapena kupitilira apo, amathanso kumwa mapiritsi okhala ndi amoxicillin a 875 mg (Flemoclav Solutab 875/125). Malangizowa amapatsanso ana awiriwa mapiritsi awiri patsiku: 250 mg kwa ana osaposa zaka ziwiri, 500 mg kwa wina aliyense. Ana ayenera kupatsidwa mankhwalawa ngati mawonekedwe a madzi kapena kuyimitsidwa kokoma.

Akuluakulu amayenera kumwa mankhwalawa chimodzimodzi ndi ana opitirira zaka 12, ndiye kuti, piritsi m'mawa ndi madzulo.

Kutenga mankhwalawa ndi chakudya sikukhudza kuyamwa kwa zinthu zomwe zimagwira. Komabe, odwala ambiri amawona kuti mankhwalawo amadziwika bwino ndi thupi ngati mumamwa mwachangu musanadye.

Kutalika kwa mankhwalawa kumatsimikiziridwa ndi dokotala, kutengera kuwuma kwa matendawa. Nthawi zambiri, maphunzirowa sapitirira masiku 14, koma m'malo apadera amatha kukhala nthawi yayitali.

Kwa anthu omwe akuvutika ndi matenda a impso a degree iliyonse, mulingo wa Flemoklav Solutab 875/125 ungasinthidwe. Malangizo ogwiritsidwira ntchito amawerenga ngati wodwala ali ndi gawo lotchedwa 30 gl / mphindi, ndiye kuti amamuika Mlingo komanso pafupipafupi pakukhazikitsa. Mwanjira ina, piritsi limodzi m'mawa ndi madzulo.

Ngati kuchuluka kwa kusefera kusakwana 30 ml / min, kuphipha kwa impso kwa clavulanic acid ndi amoxicillin kumayamba pang'onopang'ono. Chifukwa chake, wodwalayo amachepetsa mlingo wa mankhwalawa (wolembedwa "Flemoklav Solutab" wokhala ndi amoxicillin 500 mg kapena angagwiritsidwe ntchito ndi 250 mg). Komanso, ngati kuchuluka kwa kusefedwa kumachepera 30, koma kupitirira 10 mg pa mphindi, mankhwalawa amatengedwa 2 kawiri patsiku, ndipo ngati ochepera 10 mg / mphindi - 1 nthawi patsiku.

Ngati wodwala walephera aimpso, mankhwalawa amangoikidwa pokhapokha kuti azitha kuwunika ntchito ya chiwindi.

Kwa odwala omwe akudwala hemodialysis, Flemoklav Solutab sanapatsidwe. Anthu oterewa amapatsidwa mankhwala okhala ndi amoxicillin osaposa 500 mg. Mapiritsi amlomo amatengedwa kamodzi kawiri patsiku (isanachitike kapena itatha), kapena nthawi imodzi patsiku. Zimatengera momwe wodwalayo alili.

Zotsatira zoyipa

Zotsatira zoyipa zomwe zingawonekere pazinthu zilizonse zomwe zimaphatikizidwa mu Flemoklav Solutab 875/125 zanenedwa kale pamwambapa. Mu malangizo ogwiritsira ntchito mankhwalawa, akuti, pazonse zomwe zimaphatikizidwa ndi mankhwalawa zimatha kuyambitsa zotsatirazi zosayenera:

Kuchokera m'mimba:

• nseru
• dysbacteriosis, yowonetsedwa ndi m'mimba,
• kusanza
• hemorrhagic colitis,
• enterocolitis
• chiwindi
• gastritis
• cholestatic jaundice.

Kuchokera ku ziwalo zopanga magazi:

• thrombocytosis
• leukopenia
• hemolytic anemia
• thrombocytopenia
• granulocytosis,
• eosinophilia.

• mutu
• kukokana
• chizungulire
• nkhawa zosafotokozedwa
• kuvutika kugona.

• hematuria
• candidiasis
• khalid
• interstitial nephritis.

Kwa odwala ena, zomwe zaperekedwa mu malangizo a Flemoklav Solutab 875/125 zimayambitsa nkhawa. Zomwe madotolo ananena pamankhwala amaperekanso ndemanga pamndandanda waukulu kwambiri wa zomwe zimachitika chifukwa cha mankhwalawa. Tikuwonjezera kuti kugwiritsidwa ntchito kwake mwa akulu ndi ana ambiri kumatha kuyambitsa zovuta zingapo:

• zotupa pakhungu
• Matenda a Stevens-Johnson
• kukokoloka kwachisoni,
• pachimake pantulosis
• matumbo a vasculitis,
• kutupa
• dermatitis exfoliative,
• anaphylactic mantha.

Kuchita ndi mankhwala ena

Osati ndi mankhwala onse omwe angagwiritsidwe ntchito, malinga ndi malangizo, "Flemoklav Solyutab". M'mawunikidwe, odwala amawona kuti madokotala samangowachenjeza izi chifukwa cha zomwe zimachitika chifukwa chosagwirizana ndi thupi:

• Sulfanilamides, lincosamides, macrolides, tetracyclines amatulutsa zoyipa.
• Glucosamine, ma antacid, ma laxatives amachepetsa kuyamwa, ndipo ascorbic acid imawonjezera.
• Ma diuretics amawonjezera kuchuluka kwa amoxicillin mumitsempha.
• Mankhwala amachepetsa mphamvu ya kulera kwapakamwa.

Kukonzekera kwa Flemoklav Solutab 875/125 kuli ndi mitundu yambiri yomwe imafanana ndi antibacterial. Zina mwa izo ndi:

Amapezeka ndi zochulukirapo mosiyanasiyana pazinthu zazikuluzikulu. Chifukwa chake, Mlingo ndi njira zoyendetsera ntchito zimatha kusiyana ndi zomwe zidaperekedwa kwa Flemoklava Solutab. Kuti mankhwalawa azigwira bwino ntchito, ndikofunikira kuti mwayi wowagwiritsa ntchito udzatsimikizidwe ndi adokotala. Ayenera kuyika mankhwala.

Flemoklav Solyutab 875/125: malangizo, ndemanga za madokotala ndi odwala

Mwambiri, mankhwala oterowo amayenera chisamaliro ndi kudalirika. Madokotala ndi akatswiri odziwa ntchito zazifupi amalembera izi pafupipafupi, chifukwa nthawi zambiri zotsatira za chithandizo zimakhala zokwera kwambiri. Mothandizidwa ndi mankhwalawa, ndikotheka kuchiritsa odwala omwe ali ndi vuto lalikulu la bakiteriya ndipo potero kupewa zovuta zawo. Madokotala amazindikiranso kuti mankhwalawa adatsimikizira popewa kukula kwa zovuta za postoperative.

Odwala ali ndi malingaliro osiyana pang'ono pankhani ya Flemoklav Solutab 875/125. Pakuwona malangizo omwe aphatikizidwa phukusi lazinthu, anthu amazindikira kuti nthawi zina zimakhala zovuta kumvetsetsa nthawi ndi momwe angaperekere mankhwalawa kwa ana.

Koma ndemanga zambiri zoyipa zalembedwa zokhudza zovuta zingapo zomwe zimayambitsa kusokonezeka kwa chithandizo cha mankhwala. Mwa ndemanga zabwino, odwala omwe sanakumanepo ndi zovuta zilizonse pamene amamwa mankhwalawa adazindikira kuyendetsa bwino kwa Flemoklava Solutab komanso mtengo wotsika mtengo, zomwe zimapangitsa kuti mankhwalawa akhale okwera mtengo kwa anthu omwe ali ndi ndalama zambiri.