Torvacard - malangizo ogwiritsira ntchito, mawonekedwe omasulira, zikuwonetsa, zoyipa, analogi ndi mtengo

Chida chothandiza polimbana ndi atherosulinosis ndi Torvacard. Imatsitsa cholesterol yokwanira ndi 30-46%, lipoprotein wotsika kwambiri ndi 40-60%, ndipo imachepetsa triglycerides. Nthawi zambiri amatchulidwa kuti athetse kulowerera m'mitsempha limodzi ndi kuthamanga kwa magazi, matenda am'mitsempha, mtima wamatumbo, komanso matenda ena a mtima. Mankhwalawa ndi othandizadi kwa odwala matenda ashuga.

Kodi Torvacard ndi chiyani

Wopanga ku Torvacard ndi kampani ya Czech Czech Zentiva. Chipangizochi chikufotokoza za mankhwala ochepetsa mphamvu ya lipid, omwe zochita zake zimawunikidwa motsutsana ndi milomo yochepa ya lipoproteins (LDL), yomwe imakhala ndi cholesterol mthupi lonse. Kuti izi zitheke, Torvacard imachepetsa kuchuluka kwa cholesterol m'thupi (kutsika kwakanthawi kake ndi 3654%), motero mankhwalawo ndi a gulu la ma statins.

Cholesterol ndi mafuta amchere ndipo amatenga nawo mbali m'njira zambiri zomwe zikuchitika m'thupi: zimathandizira kuti pakhale vitamini D, kupanga ma asidi a bile, mankhwala a steroid, kuphatikiza maliseche. 85% ya cholesterol amapangidwa ndi thupi, ena onse amabwera ndi chakudya. Zinthu sizisungunuka m'madzi, chifukwa chake sizingalowe m'maselo ndi mtsinje wamagazi. Kuti tichite izi, zimaphatikizana ndi mapuloteni amtundu, ndikupanga lipoprotein zamitundu yosiyanasiyana.

Cholesterol imafika m'maselo oyenera monga gawo la LDL, lomwe, ngakhale limagwira gawo lofunikira, limatchedwa "cholesterol yoyipa" chifukwa limakonda kukhazikika pamakoma amitsempha yamagazi. Ma lipoproteins apamwamba kwambiri, HDL, yemwe amadziwika kuti cholesterol wabwino, ali ndi udindo wochotsa mafuta m'thupi ndi kuyeretsa makhoma a mtima. Mulingo wapamwamba wa HDL umadziwika ndi thupi lathanzi.

Ngati kuchuluka kwa LDL m'magazi kuli kwambiri, "cholesterol yabwino" imasiya kugwira ntchito zawo. Zotsatira zake, cholesterol plaque amayikidwa pamitsempha ya mtima, zomwe zimapangitsa kuti magazi azituluka chifukwa chochepetsera lumen ya m'mitsempha yamagazi. Madipoziti nthawi zambiri amawononga makoma a mitsempha ndi mitsempha, zomwe zimayambitsa kuwoneka kwa magazi, omwe amapezeka pomwe ma cellelo ndi ma cell ena amayamba kuchiritsa bala.

Popita nthawi, ma cholesterol plaque amauma ndikusintha minofu yamatenda athanzi, chifukwa chake mitsempha, mitsempha, capillaries imataya mphamvu. Mothandizidwa ndi magazi, amatumphukira nthawi zambiri, kuchititsa magazi akulu kapena ang'ono. Ngati magazi amatuluka m'chigawo cha mtima kapena ubongo, vuto la mtima limachitika. Ngakhale ndi chithandizo chakanthawi, imfa imatha kuchitika.

Kuchepetsa kapangidwe ka cholesterol, Torvacard imalepheretsa ntchito ya enzyme HMG-CoA reductase, yomwe imakhudzidwa ndikupanga mowa wamafuta. Izi zimabweretsa kutsika kwa kapangidwe kake, komanso ndi kuchepa kwa chiwerengero cha lipoproteins yotsika. Pamodzi ndi LDL, triglycerides amachepetsedwa - mtundu wamafuta womwe umapatsa thupi mphamvu ndipo umathandizira pakupanga lipoproteins. Kuphatikizanso ndikuti kuchuluka kwa "cholesterol yabwino" motsogozedwa ndi Torvacard kumawonjezeka.

Malangizo ogwiritsira ntchito Torvacard

Pa mankhwala, wodwalayo ayenera kutsatira zakudya zomwe zimapangitsa kuchepetsa milingo ya lipid. Mutha kugwiritsa ntchito mankhwalawa limodzi ndi chakudya komanso pamimba yopanda kanthu. Kutenga Torvacard pachakudya kumachepetsa mayamwidwe, koma mphamvu ya mankhwala a izi sikuchepa. Pamaso chithandizo, isanachitike, muyenera kuwunika kuchuluka kwa lipids m'magazi, kukakumana ndi mayeso ena ofunikira.

Pazitali zabwino za mankhwalawa plasma zimachitika ola limodzi kapena awiri atagwiritsa ntchito. 98% ya chinthu chofunikira chitalowetsedwa m'magazi chimamangiriza mapuloteni ake ndikuyamba ntchitoyo. Ambiri a Torvacard amasiya thupi ngati gawo la bile pambuyo pokonzedwa ndi chiwindi. Ndi mkodzo, osapitilira 2 peresenti amatuluka. Kuchotsa theka-moyo ndi maola 14.

Torvacard imatha kupondaponda ntchito ya enzyme HMG-CoA reductase chifukwa cha atorvastatin. Mankhwala amamasulidwa pamapiritsi, aliwonse - 10, 20 kapena 40 mg pazinthu izi. Paketi imodzi ili ndi miyala 30 kapena 90. Kuphatikiza pa chinthu chomwe chikugwirira ntchito, kapangidwe kake kameneka kama:

cellcrystalline cellulose - amateteza kugaya chakudya, amachepetsa kuchuluka kwa mafuta m'thupi ndi glucose, omata poizoni,
magnesium oxide - amachepetsa acidity, amalimbikitsa mphamvu yamfupa, amasinthanso kugwira ntchito kwa mtima, minofu, maselo amitsempha,
silicon dioxide - enterosorbent yomwe imakhala ndi poizoni, ma allergen, mabakiteriya ndi zinthu zina zamtopola.
croscarmellose sodium - imathandiza piritsi kusungunuka msanga mukamwa,
magnesium stearate - amalimbikitsa mapangidwe a homogeneous misa popanga mapiritsi,
hydroxypropyl selulose - thickener,
lactose monohydrate ndiwosewera.

Kukwezeka kwa lip lip (hyperlipidemia) ndi chisonyezo chokhazikitsidwa ndi Torvacard. Tengani mankhwalawo limodzi ndi zakudya zomwe zimachepetsa kuchepa kwa lipoprotein ndi triglycerides, zimawonjezera kuchuluka kwa "cholesterol yabwino." Torvacard adalembedwanso motere:

kuchuluka kwa triglycerides m'mwazi (hypertriglyceridemia),
dysbetalipoproteinemia,
kuphatikiza hypertriglyceridemia ndi hypercholesterolemia (cholesterol yayikulu),
heterozygous (pulayimale) ndi homozygous cholowa hypercholesterolemia, pamene zakudya sizothandiza,
matenda a mtima dongosolo pamaso pa dyslipidemia (kuphwanya kuchuluka kwa magazi lipids) kupewa sitiroko ndi myocardial infarction.

Ndi matenda a mtima otchulidwa, mapiritsi a Torvacard amalembedwa kuti apewe kugunda kwa mtima ndi kugunda kwa mtima, kutsata njira zobwezeretsanso zam'mimba, komanso kuchepetsa mwayi wogonekedwa m'chipatala pamaso pa mtima. Lemberani mankhwala ngati palibe zizindikiro za matenda a mtima (CHD), koma pali zofunika kuti muwoneke:

kuthamanga kwa magazi
kusuta
magawo otsika a cholesterol yabwino
zaka zopitilira 55
chibadwire.

Popewa matenda opha ziwopsezo, Torvacard amalembera odwala matenda ashuga amtundu wa 2 omwe alibe zizindikiro za matenda amtima, koma ali ndi matenda oopsa, retinopathy (kuwonongeka kwa retina), mapuloteni mu mkodzo (albuminuria), osonyeza mavuto a impso. Fotokozerani mankhwalawa ngati wodwala matenda ashuga asuta. Tiyenera kudziwa kuti atorvastatin imatha kuyambitsa matenda ashuga mwa anthu omwe amapezeka ndi matendawa, ndipo odwala matenda ashuga amawonjezera kuchuluka kwa glucose. Pachifukwa ichi, muyenera kumwa mankhwalawa Torvard, kuyang'anira mosamalitsa zomwe adotolo adziwa.

Mankhwalawa amayamba ndi mlingo wa 10 mg patsiku, womwe pang'onopang'ono umakwera mpaka 20 mg. Simungathe kumwa zoposa 80 mg wa mankhwalawa patsiku. Mlingo amasankhidwa ndi adokotala, poganizira zomwe akuwunika, mikhalidwe ya wodwalayo. Kwa odwala omwe ali ndi homozygous hypercholesterolemia, mlingo ndendende ndi 80 mg. Kutalika kwa nthawi ya mankhwala kutsimikiza ndi dokotala. Zowoneka zimawoneka masabata awiri itatha yoyamba kumwa. Patatha mwezi umodzi chiyambireni chithandizo, mayeso amayenera kutengedwa kuti akhale ndi ma lipids am'magazi ndipo njira yochiritsira imayenera kusinthidwa.

Contraindication

Torvacard imakonzedwa m'chiwindi musanachokere m'thupi, ndiye kuti mankhwalawa amakanizidwa chifukwa cha zotupa zazikuluzikulu za chiwalochi. Simungathe kumwa mankhwalawa ndi:

milingo yokwezeka ya ma transaminase - michere yomwe imayendetsa kagayidwe m'thupi, kuchuluka kwake komwe kumachulukana ndimatenda a chiwindi.
kusaloledwa kwachilendewu, glucose, kuchepa kwa msana,
wazaka 18
ziwengo zosiyanasiyana za mankhwala.

Osati mankhwala a Torvacard azimayi amisinkhu yosabereka omwe sagwiritsa ntchito njira zakulera: ma statin amatha kuvulaza thupi la mwana wosabadwa. Pa nthawi ya pakati, kuchuluka kwa cholesterol ndi triglycerides kumachulukitsidwa nthawi zonse, chifukwa zinthu izi ndizofunikira pakapangidwe ka mwana wosabadwayo. Kafukufuku wokhudzana ndi mankhwalawa kwa makanda sanachitike, koma zimadziwika kuti ma statins amatha kulowa mkaka wa m'mawere ndikuwonetsa zoyipa m'mwana wakhanda panthawi yomwe akukonzekera.

Torvacard amalembedwa mosamala pamavuto a metabolism, usawa wamagetsi am'madzi, komanso kuthamanga kwa magazi. Uchidakwa, matenda a chiwindi, matenda a shuga, khunyu, kuvulala kwaposachedwa, kuchitapo kanthu kochita maopaleshoni kumafunikanso njira yochenjera mukamagwiritsa ntchito mankhwalawa, kutsatira ndendende ndi kumwa mankhwalawo.

Zotsatira zoyipa

Kutenga Torvacard kumatha kuyambitsa mavuto. Kuchokera wamanjenje kuonedwa:

kusowa tulo
mutu
kukhumudwa
paresthesia - mtundu wina wamatenda amtundu wotentha ndi moto, kuwonda, tsekwe,
ataxia - kuphwanya mgwirizano wa kayendedwe ka minofu yosiyanasiyana,
neuropathy ndi chosasinthika-dystrophic lesion yamitsempha yamitsempha yosakhala yotupa.

Pakhoza kukhalanso mavuto ndi kugaya kwam'mimba: kupweteka m'mimba, kusanza, kusanza, kudzimbidwa, kusintha pakulakalaka, dyspepsia (chovuta ndi chimbudzi chopweteka). Hepatitis, jaundice, kapamba angachitike. Thupi la minofu ndi mafupa amatha kuyankha ku Torvacard - kukokana, kupweteka m'misempha ndi mafupa, kumbuyo, myositis (kutupa kwa minofu yam'mimba).

Zina mwazotsatira zoyipa za mankhwalawa ndi kupweteka pachifuwa, tinnitus, kuchepa tsitsi, kufooka, kunenepa kwambiri. Nthawi zina kulephera kwa impso kumachitika, mwa amuna - kusabala. Chiwopsezo cha Torvacard chimadziwonetsa ngati urticaria, kuyabwa, khungu rede, zotupa, kutupa. Kuyesedwa kwa magazi kumatha kuwonetsa kuchepa kwa kuchuluka kwa mapulogalamu, kuwonjezeka kwa ntchito ya ma enzymes a chiwindi, creatine phosphokinase, komanso kusinthasintha kwa milingo ya shuga.

Kutumiza kwa Torvacard munthawi yomweyo ndi mankhwala ena kumafunikira kuonana ndi dokotala kuti mupewe zovuta. Ndizowopsa kuphatikiza atorvastatin ndi mankhwala omwe amawonjezera chidwi chake: kuphatikiza koteroko kumatha kuyambitsa rhabdomyolysis (kuwonongeka kwa minofu yamafupa). Ngati wodwala atha kumwa mankhwalawa, dokotala amamulembera mlingo wocheperako wa Torvacard wodwala amayang'aniridwa mosalekeza.

Kufotokozera ndi kapangidwe

Mapiritsiwo ndi oval, biconvex. Amakhala atakutidwa ndi filimu yoyera kapena yoyera.

Monga yogwira zinthu zimakhala ndi calcium calcium. Zinthu zotsatirazi zili ngati zina zowonjezera:

magnesium oxide
MCC
shuga mkaka
Aerosil
sodium croscarmellose,
E 572,
otsika ochepa hyprolose.

Chipolopolochi chimapangidwa ndi zinthu zotsatirazi:

hypopellose,
propylene glycol 6000,
talcum ufa
titanium yoyera.

Mawonekedwe ndi kipimo

Mankhwala Torvacard ali m'gulu la mankhwala a hypolipidemic, ma statins. Malinga ndi kufotokozera mu malangizowo, ndi inhibitor ya HMG-CoA reductase enzyme yomwe imatembenuza gawo lapansi kukhala mevalonic acid. Kuponderezedwa kwa GMG-CoA-kuchepetsa kumapitirira Maola 21-29 chifukwa cha kupezeka kwa mamolekyulu atatha hepatic metabolism. Chofunikira chachikulu, malinga ndi malangizo a kaundula wa mankhwala (RLS) ndi calcium atorvastatin. Zida zothandizira zimaphatikizapo magnesium oxide, silicon dioxide, lactose monohydrate, hydroxypropyl ndi microcrystalline cellulose.

Njira yayikulu ya pharmacological ya torvacard mu malangizo ndi yachepetsa kapangidwe ka LDL m'chiwindi, komanso kuwonjezera - kuwonjezeka kolimbikira kwa zochitika pakulumikizana ndi ma receptor a chidutswa cha cholesterol ichi. Njira yopangira mankhwalawa ndi mapiritsi, atakulungidwa pamwamba, mawonekedwe ofanana ndi makapisozi. Amapezeka muzosankha zitatu - - Torvacard 10 mg, Torvacard 20 mg, Torvacard 40 mg.

Zotsatira za pharmacological wa Torvacard

Torvacard ndi mankhwala omwe ali m'gulu la mankhwala ochepetsa lipid. Izi zikutanthauza kuti amachepetsa kuchuluka kwa lipids m'magazi, ndipo choyambirira, amachepetsa cholesterol.

Mankhwala ochepetsa a Lipid amagawidwa, nawonso, m'magulu ambiri, ndipo Torvakard ili m'gulu lotchedwa statins. Ndi osokoneza mpikisano wosankha wa HMG-CoA reductase.

HMG-CoA reductase ndi enzyme yomwe imayang'anira kusintha kwa 3-hydroxy-3-methylglutaryl coenzyme A kukhala mevalonic acid. Mevalonic acid ndi mtundu wa cholesterol precursor.

Makina ochitapo kanthu a Torvacard ndikuti amalepheretsa, ndiko kuti, akuletsa kusinthaku, akupikisana ndi ndikuletsa HMG-CoA reductase. Amadziwika kuti cholesterol, komanso triglycerides, amaphatikizidwa ndi mapangidwe ochepetsa kwambiri a lipoproteins, omwe pambuyo pake amasintha kukhala otsika osalimba a lipoproteins, amalumikizana ndi ma receptors awo apadera.

The yogwira thunthu wa Torvacard - atorvastatin - amachititsa kuchepetsa cholesterol ndi otsika kwambiri otsika lipoproteins, amathandizira kukulitsa otsika kachulukidwe lipoprotein zolandilira mu chiwindi, pamalo maselo, zomwe zimakhudza kupititsa patsogolo kwawo kukoka komanso kuwonongeka kwawo.

Torvacard imachepetsa mapangidwe a lipoproteins otsika kwambiri kwa odwala omwe ali ndi matenda monga homozygous Famel hypercholesterolemia, omwe nthawi zambiri amakhala ovuta kuchiza.

Komanso, mankhwalawa amathandizira kukulitsa kuchuluka kwa lipoprotein yapamwamba yomwe imayambitsa kupangira cholesterol "yabwino".

Pharmacokinetics ndi pharmacodynamics

Pharmacokinetics ndizosintha zomwe zimachitika ndi mankhwalawo womwewo m'thupi la munthu. Kunyowa kwake, ndiye kuti, mayamwidwe, ndi kumtunda. Komanso, mankhwalawa amafikira kwambiri m'magazi, pakatha pafupifupi ola limodzi. Kuphatikiza apo, mwa amayi, chiwerengero chofika mofulumira kwambiri chimakhala pafupifupi 20%. Mwa anthu omwe akuvutika ndi matenda a chiwindi chifukwa cha uchidakwa, kuponderezedwa pakokha kumakhala kokwanira kakhumi ndi kasanu kuposa masiku onse, ndipo kuchuluka kwake kumakwaniritsidwa nthawi 11.

Mlingo wa mayamwidwe wa Torvacard umakhudzana mwachindunji ndi chakudya, chifukwa umachepetsa mayamwidwe, koma sizikhudza kuchepa kwa kachulukidwe kochepa kopoprotein cholesterol. Ngati mumwa mankhwalawa madzulo, asanagone, ndiye kuti kuchuluka kwake m'magazi, mosiyana ndi mlingo wam'mawa, kumatsika kwambiri. Zinapezekanso kuti mtundu waukulu wa mankhwalawo, umatheka mwachangu.

The bioavailability wa Torvacard ndi 12% chifukwa chodutsa mucous nembanemba cha kupukusa chakudya ndi kudutsa chiwindi, kumene pang'ono zimapukusidwa.

Mankhwala ali pafupifupi 100% okhala ndi mapuloteni a plasma. Pambuyo pakusintha pang'ono kwa chiwindi chifukwa cha zochita zapadera za isoenzymes, metabolites yogwira imapangidwa, yomwe imapangitsa kwambiri Torvacard - inhibit HMG-CoA reductase.

Pambuyo pakusintha kwina m'chiwindi, mankhwala omwe ali ndi bile amalowa m'matumbo, omwe amachotsa kwathunthu m'thupi. Hafu ya moyo wa Torvacard - nthawi yomwe kuchuluka kwa mankhwalawa m'thupi kumachepa chimodzimodzi kawiri - ndi maola 14.

Zotsatira za mankhwalawa zimawonekera pafupifupi tsiku limodzi chifukwa cha zomwe zimatsala metabolites.Mu mkodzo, mankhwala ochepa amatha kuwoneka.

Ndizoyenera kuganizira kuti pa hemodialysis siiwonetsedwa.

Zisonyezero zamankhwala

Torvacard ili ndi mawonekedwe osiyanasiyana.

Dziwani kuti mankhwalawa ali ndi mndandanda wonse wazomwe mungagwiritse ntchito, muzikumbukira popereka mankhwala.

Malangizo ogwiritsira ntchito akuwonetsa milandu yonse yogwiritsa ntchito mankhwala osokoneza bongo.

Pakati pawo, zazikuluzikulu ndi izi:

Torvacard adalembedwa kuti achepetse cholesterol yathunthu, komanso yogwirizana ndi otsika osachulukitsa lipoprotein, kutsitsa apolipoprotein B, komanso triglycerides, ndikuwonjezera kuchuluka kwa cholesterol yapamwamba kwambiri yaopoprotein kwa anthu omwe ali ndi vuto la heterozygous kapena puloguloprotelemia yachiwiri, komanso mtundu II lipid lipidemia. . Zotsatira zake zimawoneka pokhapokha mukudya.
Komanso, pakudya, Torvard amagwiritsidwa ntchito pochiza matenda amkati mwa hypertriglyceridemia wa mtundu wachinayi malinga ndi Frederickson, komanso mankhwalawa dysbetalipoproteinemia a mtundu wachitatu, momwe machitidwe sanali kudya.
Mankhwalawa amagwiritsidwa ntchito ndi akatswiri ambiri kuti achepetse kuchuluka kwa cholesterol kwathunthu ndi lipoproteins yotsika mu matenda monga homozygous Famel hypercholesterolemia, ngati zakudya ndi njira zina zosagwiritsa ntchito mankhwalawa sizinakhalepo ndi zotsatira zake. Makamaka ngati mankhwala a mzere wachiwiri.

Kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito pamatenda a mtima ndi mtima mwa odwala omwe achulukitsa zinthu zomwe zingayambitse matenda a mtima. Izi ndi zaka zopitilira 50, matenda oopsa, kusuta, kupukusa kwamitsempha yamagazi, matenda ashuga, impso, matenda amitsempha, komanso kupezeka kwa matenda amtima mwa okondedwa.

Imagwira ntchito makamaka ndi dyslipidemia, popeza imaletsa kukhazikika kwa matenda a mtima, sitiroko, ngakhale kufa.

Zotsatira zoyipa zimagwiritsa ntchito mankhwalawa

Mukamagwiritsa ntchito mankhwalawa wodwala, mungathe kuona zovuta zosiyanasiyana.

Kupezeka kotheka kwa zoyipa kumayenera kuganiziridwanso mukamapereka mankhwala.

Zotsatira zoyipa zambiri mukamagwiritsa ntchito mankhwalawa zimayambitsa kudziletsa pakokha pa mankhwala. Mankhwalawo ali ndi ufulu wosankha dokotala yekha, poganizira mawonekedwe a thupi la wodwalayo.

Mukamagwiritsa ntchito mankhwala a Torvakard, mitundu yotsatirayi yoyipa imachitika:

Pakati ndi zotumphukira mantha dongosolo - mutu, chizungulire, ulesi, kusowa tulo, zoopsa usiku, kukumbukira kuwonongeka, kuchepa kapena kusokonezeka kwa mphamvu zopumira, kukhumudwa, ataxia.
Matumbo dongosolo - kudzimbidwa kapena kutsegula m'mimba, kumva kuperewera, kupindika, malo ochepetsa, kupweteka kwamchigawo cham'mimba, kuchepa kwamphamvu kwa chilala, komwe kumayambitsa matenda a anorexia, ndi njira inanso yozungulira, kutupa kwake mu chiwindi ndi kapamba, jaundice chifukwa cha kuzimiririka kwa bile,
Matenda a minofu ndi mafupa - nthawi zambiri pamakhala kupweteka kwamisempha ndi mafupa, myopathy, kutupa kwa minofu, minyewa ya m'mimba, kupweteka kumbuyo, kupweteka kwam'mimba.
Mawonetseredwe a ziwengo - kuyabwa ndi pakhungu pakhungu, urticaria, matupi awo sagwirizana ndi omwe amapezeka msanga (anaphylactic mantha), Stevens-Johnson ndi Lyell syndromes, angioedema, erythema,
Zizindikiro zasayansi - kuwonjezeka kapena kuchepa kwa shuga m'magazi, kuwonjezeka kwa ntchito ya creatiphosphokinase, alanine aminotransferase ndi aspartate aminotransferase, kuchuluka kwa hemoglobin wa glycated,
Ena - kupweteka pachifuwa, kutupa kwa m'munsi komanso kumtunda, kusabala, chidwi alopecia, kulemera kwakukulu, kufooka konsekonse, kuchepa kwa maselo am'magazi, kulephera kwachiwiri kwaimpso.

Zotsatira zoyipa zomwe zili ndi mankhwala onse a gulu la statin zimasiyananso:

yafupika libido
gynecomastia - kukula kwa mabere am'mimba mwa amuna,
kusokonezeka kwa minofu,
Kukhumudwa
matenda osowa a m'mapapo omwe ali ndi chithandizo chambiri,
mawonekedwe a shuga.

Chisamaliro chapadera chikuyenera kuchitika mukamamwa Torvacard ndi cytostatics, fibrate, maantibayotiki ndi mankhwala antifungal, chifukwa sizigwirizana nthawi zonse. Izi zimagwiranso ntchito pamtima glycosides, makamaka Digoxin.

Zofanizira zotere za Torvacard zimapangidwa monga Lovastatin, Rosuvastatin, Vasilip, Liprimar, Akorta, Atorvastatin, Zokor.

Ndemanga za mankhwalawa ndizabwino kwambiri, chifukwa ma statins ndi gulu lothandiza kwambiri la mankhwala lomwe limatsitsa cholesterol.

Akatswiri amalankhula za ma statins mu kanema munkhaniyi.

Gulu la mankhwala

Chithandizo chogwira ntchito mosankha komanso mwampikisano chimalepheretsa HMG-CoA reductase, enzyme yomwe ikukhudzidwa ndikupanga ma steroid, kuphatikizapo cholesterol. Zimawonjezeranso kuchuluka kwa zolandila za LDL mu chiwindi, zomwe zimapangitsa kuti pakhale kuchuluka ndi kuwononga kwa LDL.

Atorvastatin amachepetsa kuchuluka kwa LDL mwa odwala omwe ali ndi homozygous Famer hypercholesterolemia, omwe, monga lamulo, sangathe kuthandizidwa ndi mankhwala ena a hypolipidemic.

Kuchuluka kwa ndende ya atorvastatin kumachitika pakadutsa maola awiri kuchokera chakudya. Mukamamwa mankhwalawa madzulo, kuchuluka kwake kumakhala kotsika kuposa 30 m'mawa. The bioavailability ya mankhwalawa ndi 12% yokha, izi zimachitika chifukwa chakuti chinthu chomwe chimagwiritsidwa ntchito chimapangidwira mu mucous membrane wam'mimba komanso m'chiwindi. Kufikira 98% ya mankhwalawa amamangidwa kumapuloteni amwazi. Amachotsedwa m'thupi ndi bile, theka la moyo wa maola 14.

Kwa akuluakulu

Torasemide kuphatikiza zakudya zimayikidwa:

Kuchepetsa kuchuluka kwa cholesterol okwanira, otsika osalimba lipoprotein, apolipoprotein B ndi triglycerides, ndikuwonjezera zomwe zili lipoproteins yapamwamba kwambiri kwa odwala omwe ali ndi hyperlipidemia yapamwamba, heterozygous achibale komanso osakhala achibale a hyperlipidemia, ndi mitundu ya II (II) ya II.
ndi kuchuluka kwa triglycerides (mtundu IV malinga ndi Fredrickson),
ndi dysbetalipoproteinemia (mtundu wa III malinga ndi Fredrickson),
ndi homozygous mabanja a hypercholesterolemia kuti achepetse kuchuluka kwa cholesterol ndi otsika kachulukidwe lipoproteins.

Torasemide ndi analamula kuti matenda a mtima dongosolo kwa odwala omwe ali pachiwopsezo cha matenda a mtima - - zaka 55, chikumbumtima, magazi, kuthamanga, matenda amitsempha, mbiri ya sitiroko, matenda amitsempha yamagazi, mapuloteni mu mkodzo, matenda amtima achibale, kuphatikizapo chifukwa cha dyslipidemia. Odwala awa, kumwa mankhwalawa kumachepetsa chiyembekezo chofuna kufa, matenda amisempha, matenda opha ziwalo, kugonekanso kuchipatala chifukwa cha angina pectoris ndi kufunika kosinthanso.

Torvacard sayenera kutumizidwa kwa ana.

Kwa pakati ndi kuyamwitsa

Torvacard imaphatikizidwa kwa odwala omwe ali ndi udindo ndi kuyamwitsa. Mankhwalawa sayenera kugwiritsidwa ntchito kwa akazi azaka zakubala ngati sagwiritsa ntchito njira zodalirika zolerera. Pali milandu yodziwika ya kubadwa kwa ana omwe ali ndi vuto lobadwa nawo mu nthawi yomwe nkhani zawo zinatengedwa panthawi ya mimba ya Torvacard.

Zotsatira zoyipa

Zotsatira zotsatirazi zimatha kuchitika ndi chithandizo cha Torvacard:

mutu, kusabala, chizungulire, kusokonezeka kwa tulo, komwe kumatha kuwonetsedwa ndi zovuta, kugona, kugona, kugona kapena kukumbukira, kufooka, zotumphukira za polyneuropathy, hypesthesia, paresthesia, ataxia,
kupweteka kwam'mimba ndi m'mimba, mseru, kusanza, kutsegula m'mimba, kudzimbidwa, chiwopsezo cha hepatitis, kutupa kwa kapamba, jaundice wa cholestatic, kudya kwambiri, kusowa kudya kwathunthu,
kupweteka kwa minofu ndi kuphatikizika, kupweteka kwa msana, myopathy, kutupa kwa mafupa, mafupa, miyendo,
thupi lawo siligwirizana, lomwe limawonetsedwa ndi zotupa, kuyabwa pakhungu, uritisaria, edema ya Quincke, anaphylaxis, zotupa zakuluzikulu, zotupa za erythema multiforme.
kuchuluka kapena kuchepa kwa shuga wamagazi,
kuchuluka kwa glycosylated hemoglobin, ntchito ya michere ya chiwindi,
kupweteka pachifuwa
kutupa kwa malekezero
kukanika kwa erectile
kuchepa kwa tsitsi
kulira m'makutu
kutsika kwa magazi m'magazi,
kulephera kwachiwiri kwaimpso
kunenepa
kufooka ndi malaise.

Kuchita ndi mankhwala ena

Ndi makonzedwe apakati pa atorvastatin ndi cyclosporine, ma fibrate, erythromycin, clarithromycin, immunosuppressants ndi antimycotic a gulu la azole, nicotinic acid ndi nicotinamide, mankhwala omwe amalepheretsa kagayidwe kachakudya, ndikugwira nawo 3A4 CYP450 isoenzymes, ndi / kapena kutumizira, kugwiritsa ntchito kuchuluka, ndi chiopsezo cha myopathy. Chifukwa chake, kuphatikiza kotereku ndikosapeweka, muyenera kuganizira zoopsa zake ndi mapindu ake. Odwala omwe amalandira chithandizo chophatikizira choterechi amayenera kuyang'aniridwa ndi achipatala pafupipafupi, ndipo ngati ntchito yapamwamba ya creatine kinase kapena zizindikiro za myopathy zapezeka, ziyenera kusiyidwa.

Colestipol amachepetsa kuchuluka kwa atorvastatin, koma kutsitsa kwa lipid kumapangitsa kuti kuphatikiza uku kukhale kwakukulu kuposa komweko kwa mtundu uliwonse wa mankhwalawo mosiyana.

Atorvastatin imawonjezera mphamvu ya mankhwala omwe amachepetsa mphamvu ya mahomoni amkati amkati.

Popanga atorvastatin muyezo wa tsiku ndi tsiku wa 80 mg munthawi yomweyo ndi njira zakulera za pakamwa zochokera ku norethindrone ndi ethinidestraliol, kuwonjezereka kwa kuchuluka kwa njira zakulera m'magazi kunawonedwa.

Mukamamwa atorvastatin muyezo wa tsiku ndi tsiku wa 80 mg ndi digoxin, kuwonjezereka kwa kuchuluka kwa mtima glycoside kumawonedwa.

Malangizo apadera

Musanatenge Torvacard, kuchepetsa cholesterol ndikofunikira kuyesa ndi chakudya, kuchuluka kwa masewera olimbitsa thupi, kuchepa thupi kwa odwala omwe ali ndi kunenepa kwambiri komanso kuthandizira ma pathologies ena.

Potengera momwe mankhwalawo amathandizira, chiwindi chimagwira ntchito ngati sichili bwino, kotero mawonekedwe ake amayenera kuwunika asanayambe Torvacard, masabata 6 ndi 12 pambuyo poyambira chithandizo, pambuyo pakuwonjezereka kwa mankhwala, komanso nthawi ndi nthawi, mwachitsanzo, kamodzi pa miyezi isanu ndi umodzi. Pa mankhwala, kuwonjezeka kwa ntchito ya michere ya chiwindi kungawonedwe, makamaka m'miyezi 3 yoyambirira yamankhwala, koma ngati izi zikuwonjezeredwa ndi nthawi yopitilira 3, muyenera kuchepetsa kuchuluka kwa atorvastatin kapena kusiya kumwa.

Komanso, mankhwalawa amayenera kusiyidwa ngati pali zizindikiro za myopathy, kukhalapo kwa zinthu zomwe zingayambitse matenda a impso chifukwa cha kuchepa kwa magazi, kuchepa kwa magazi, kuthana kwambiri, opaleshoni yayikulu, kuvulala, kusokonekera kosaletseka, kusokonezeka kwa metabolic, mavuto a endocrine.

Potengera momwe mankhwalawo amathandizira, kuchuluka kwa shuga m'thupi kumatha kuchuluka, mwa odwala ena, chiwonetsero cha matenda a shuga ndizotheka, zomwe zimafuna kuikidwa kwa othandizira a hypoglycemic.

Mankhwala samakhudza kuyendetsa galimoto.

Malo osungira

Torvacard iyenera kusungidwa kuti isachitike kwa ana kwa zaka 4 kuyambira tsiku lopangira mankhwalawo. Mankhwala amaperekedwa kuchokera ku mankhwala monga mankhwala a dokotala, kotero saloledwa kudzipenda.

Anvistat. Ichi ndi mankhwala aku India omwe amapezeka pamapiritsi oblong. Iwo, mosiyana ndi mapiritsi a Torvacard, ali pachiwopsezo, chofunikira kwa odwala omwe sangathe kumeza mankhwalawo kwathunthu.
Atomax Mankhwalawa amapangidwa ndi kampani yaku India HETERO DRUGS Limited. Imapezeka mozungulira, mapiritsi a biconvex okhala ndi chiopsezo. Alumali moyo wa mankhwala 2 zaka.
Atorvastatin. Mankhwalawa amapangidwa ndi makampani angapo aku Russia. Mtengo wake ndi wotsika kuposa wa Torvacard, koma monga wotsiriza, mutha kukhala otsimikiza za kusiyana kwa mankhwala apakhomo. Moyo wa alumali wa Atorvastatin ukhoza kukhala wamfupi kuposa wa Torvacard, mwachitsanzo, ndi zaka 3 kwa mankhwala omwe amapangidwa ndi Biocom CJSC.

Mutha kutenga analogue m'malo mwa Torvacard pokhapokha mutakumana ndi dokotala.

Mtengo wa Torvacard ndi avareji ya ma ruble 680. Mitengo imachokera ku 235 mpaka 1670 rubles.

Gwiritsani ntchito pa nthawi yoyembekezera

Kukhala ndi pakati ndikugwiritsira ntchito statin iyi ndikunyoza. Malinga ndi malangizo, mankhwalawa samatchulidwanso panthawi yoyamwitsa, chifukwa chakuti sichiwululidwa mosamala ngati chinthucho chikugwira, atorvastatin, chimadutsa mkaka wa m'mawere.

Malinga ndi malangizowo, silinafotokozeredwe machitidwe azachipatala a ana chifukwa chosowa umboni wazogwiritsira ntchito pamalonda awa.

Kuchita ndi mankhwala ena

Chiwopsezo chowonekera ndi kupitilira kwa myopathy popereka mankhwala ochepetsa lipid omwe amachepetsa mapangidwe a cholesterol amawonjezereka pogwiritsa ntchito mitundu ingapo ya mankhwala. Makamaka, michere, ma antimicrobials (azole derivatives), cyclosporine, ndi mankhwala ena angapo. Malangizowa ali ndi mndandanda wazida, mgwirizano womwe umakhala ndi zinthu zingapo:

Ndi kufanana kwa torvacard ndi phenazone kapena warfarin - Palibe zofunikira pakuchitikirana zomwe zapezeka.
Ndi kuphatikiza kwa mankhwala, monga cyclosporine fibrate (gemfibrozil ndi mankhwala ena a gululi), immunosuppressants, antimycotic agents of azole derivatives, mankhwala omwe amalepheretsa kagayidwe ka CYP450 isoenzyme 3A4, plasma ndende ya Torvacard imachulukirachulukira. Kuyang'anira odwala ngati oterowo, ndipo ngati ndi kotheka, kuperekedwa kwa mankhwala pakungoyamba Mlingo kumalimbikitsa.
Ndi munthawi yomweyo kugwiritsa ntchito Torvacard mu 10 mg patsiku ndi azithromycin kuchuluka kwa 500 mg patsiku, AUC yoyamba mwa plasma sanasinthe.
Momwe amagwiritsidwira ntchito mankhwalawa ndi othandizira, omwe amakhala ndi ma hydroxyxides a magnesium ndi aluminium, ma statin AUC m'magazi anachepa pafupifupi 30-35%, koma zotsatira zamankhwala sizinasinthe komanso kuchuluka kwa kuchepa kwa LDL m'magazi a m'magazi sikunasinthe, komabe, adokotala kuwongolera ndikofunikira.
Colestipol. Mofananamo ndi ma statins omwe akuphunziridwa masiku ano, ndimagwiritsanso ntchito ma lipid ochepetsa omwe ali m'gulu la ma resion anion. Ndi ntchito yochezeka, kuchuluka kwa plasma ya Torvacard kunachepa pafupifupi kotala, koma kuchuluka kwa zamankhwala kuyambira pachiyambi chogwiritsa ntchito mankhwala mosiyanasiyana kunali kwapamwamba kuposa aliyense wa iwo mosiyana.
Kulera kwamlomo. Kufanana kwa kayendetsedwe ka mankhwala omwe amapezeka pamankhwala akuluakulu (80 mamiligalamu) omwe ali ndi mankhwalawa kumabweretsa kuwonjezeka kowoneka bwino kwamagulu a mahomoni a mankhwala. Malinga ndi malangizo, AUC ya ethinyl estradiol imakula ndi 20%, ndipo norethisterone ndi 30%.
Digoxin. Kuphatikizidwa ndi digoxin kumabweretsa chakuti kuchuluka kwa plasma torvacard kumawonjezeka ndi 20%. Odwala omwe amalandira digoxin kuphatikiza ndi statin pa mlingo waukulu kwambiri (ma milligram 80 - pazitali, zowongoleredwa ndi malangizo) amayenera kuyang'aniridwa kwathunthu.

Mtengo wa mankhwala

Mtengo wapakati wa mankhwala pamashelefu apadokotala umatengera mlingo wake ndi kuchuluka kwa mapiritsi okhala paketi. Ku Russia mtengo wamba wa Torvakard mdziko muno ndi:

Torvacard 10 mg - ma ruble pafupifupi 240-280 mapiritsi 30, chifukwa mapiritsi 90 mudzayenera kupereka kuchuluka kwa ma 700 rub7 700.
Torvacard 20 mg - pafupifupi ma ruble a 360-430 a mapiritsi 30 ndi 1050 - 1070 ma ruble mapiritsi 90, motsatana.
Torvacard 40 mg - pafupifupi 540 - 590 ma ruble a mapiritsi 30 ndi 1350 - 1450 ma ruble 90 zidutswa.

Mu Chiyukireniya Msika wogulitsa mankhwala ku Torvacard muma pharmacies ndi awa:

Torvacard 10 mg - pafupifupi 110-150 UAH mapiritsi 30, chifukwa mapiritsi 90 mudzafunika kupereka kuchuluka kwa mitundu 310 - 370 UAH.
Torvacard 20 mg - pafupifupi 90 - 110 UAH mapiritsi 30 ndi 320 - 370 UAH mapiritsi 90, motero.
Torvacard 40 mg - mtengo umasiyana kuchokera ku 220 mpaka 250 UAH pa mapiritsi 30.

Ndondomeko yamitengo imadalira dzikolo ndi wopanga, pa mawonekedwe amsika wamankhwala, pamtengo wam'deralo.

Analogs Torvakard

Torvacard - mankhwala omwe adziwonetsa okha bwino, amawonetsa zotsatira zabwino zamankhwala ndipo ndiwotsika mtengo - wotsika mtengo. Komabe, nthawi zina (kusalolera payekhapayekha, kusintha kwa mankhwala omwe mumalandira, kusintha kwa wodwala), zingakhale zofunikira kusankha analogue m'malo mwa torvacard.

Pali zolowa m'malo ndi ntchito yomweyo Malangizo, monga Torvakard - Atorvastatin. Izi zikuphatikizapo Atokor, Atoris, Liprimar, Torvazin, Tulip, Livostor.

Kuphatikiza pa iwo, akatswiri azachipatala amatha kusankha mnzake wogulitsa. gululi lilinso ndi ma statins. Izi zikuphatikiza mankhwala monga Acorta, Rosuvastatin, Krestor, Rosucard, Rosart, Lipostat, Roxer, Simgal ndi ena.

Kugwiritsa Ntchito

Pakati pa madokotala, za ndemanga za torvakard ndizosangalatsa kwambiri. Nthawi zambiri limawonekera poika hypercholesterolemia yamitundu yosiyanasiyana. Kwa zaka zambiri, mankhwalawa adatsimikizika mogwira ntchito.

Zhilinov S.A. Endocrinologist, Ufa: “Kwa nthawi yayitali ndakhala ndikuwathandizira. Nthawi zonse ndimawona zotsatira zabwino zokhala ndi zovuta zochepa kapena zovuta zina. Imachita bwino kwambiri pochiza mikhalidwe yokhala ndi cholesterol yambiri. Kuphatikiza apo, poletsa mtima ischemia, imakhalanso ndi gawo lofunikira. Ndipo pamtengo amapezeka ndi pafupifupi wodwala aliyense. ”

Monga madotolo, odwala nawonso amasangalatsidwa ndi mankhwalawa. Poyerekeza ndi ma statins ena otchuka, mtengo ndi kupezeka kwa mankhwalawa ndizowoneka bwino.

Vasilenko S.K., woyendetsa taxi, wazaka 50, Kerch: “Kwa zaka 6 zapitazi ndakhala ndi cholesterol. Ndinapita kuchipatala, dotolo wa komweko adandiuza kuti ndiwapatse Torvakard. Poyamba ndinkaganiza kuti ndawononga ndalama pachabe, koma kenako ndinawerenga malangizo a mankhwalawo, ndimamvera malangizo a dotolo ndipo ndinazindikira kuti zotsatira zake sizinali zadzidzidzi, koma pang'onopang'ono. Ndipo patatha milungu iwiri, inenso ndidamva kusintha kwamtundu wabwino. Tsopano ndilibe madandaulo odziwika, ndimadziona kuti ndine wachinyamata zaka khumi. "

Chegoday E.A. Zaka 66, Voronezh: Kuyambira ndili mwana ndimakhala ndi vuto lolesteroli yambiri. Ndisanatenge torvacard, ndimamwa lypimar - ndikuweruza ndi malangizo, ali ndi mawonekedwe ofanana. Koma mitengo ya lypimar tsopano yatsika, motero dotolo adanenanso kuti ndithane ndi mankhwala otsika mtengo. Ineyo pandekha sindikuwona kusiyana kulikonse, palibe zotsatira zoyipa kuchokera pamndandanda wawukuluwo mu malangizo, sindinapeze pa mankhwalawo kapena izi. Ndizomvetsa chisoni kuti mapiritsiwa ayenera kumwa tsopano moyo wanga wonse. "

Panchenko Vera, wazaka 39, p. Antonovka: "Abambo anga akhala akudwala matenda ashuga amitundu iwiri, asanafike chithandizo, kuchuluka kwa shuga m'magazi opanda kanthu mpaka 8-9. Ali ndi kulemera kowonjezera thupi, ndipo monga adokotala ananena, ndichifukwa chake cholesterol imapita pang'ono pakuwunika. Ku chipatala chachigawo, tidalangizidwa mwamphamvu, kuwonjezera pa chithandizo chathu chonse, kumwa mamiligirama 20 a torvacard usiku uliwonse, malinga ndi malangizo. Zidakhala zabwino kwambiri - muyenera kumwa kamodzi kokha patsiku. Zomwe mukufuna, chifukwa bambo ali ndi zaka pafupifupi 70 ndipo zaka zawo zimamuvuta kukumbukira mapiritsi onse. Komanso, malangizowo akuti kumwa mapiritsi sikudalira chakudya - ichi ndi matenda a shuga a abambo ambiri. M'mwezi woyamba, m'mene tinayamba kumwa mankhwalawa, panali kuchepa kwakukulu kwa cholesterol, ndipo tsopano zonse zikuyenda naye, ali bwino».

Monga mukuwonera, kuwunikira powunikira madotolo onse ndi odwala awo, mankhwala osankhidwa a lipid-otsitsa - Torvakard - ali ndi mphamvu yokwanira ndipo ali ponseponse muzochita zamankhwala. Nthawi zambiri pamakhala ndemanga za mtengo wosangalatsa wa statin iyi. Iyenera kukumbukiridwa ndikukumbukira kuti ndizotheka kupereka torvacard pokhapokha pakufufuza kwathunthu ndikulankhulana ndi akatswiri olondola, kutsatira malangizo ake okhwima.