Lozap 50 mg - malangizo ogwiritsira ntchito

50 mg mapiritsi okhala ndi mafilimu

Piritsi limodzi lili

yogwira mankhwala - losartan potaziyamu 50 mg,
maipiipi: mannitol - 50,00 mg, cellcrystalline cellulose - 80.00 mg, crospovidone - 10,00 mg, anhydrous colloidal silicon dioxide - 2.00 mg, talc - 4.00 mg, magnesium stearate - 4,00 mg,
Sepifilm 752 yoyera yoyera ndi chipolopolo: hydroxypropyl methylcellulose, cellcrystalline cellulose, macrogol stearate 2000, titanium dioxide (E171), macrogol 6000

Mapiritsi okhala ndi mawonekedwe ozungulira, biconvex, halved, atakulungidwa ndi utoto wamtundu wa zoyera kapena pafupifupi zoyera, pafupifupi 11.0 x 5.5 mm kukula

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, losartan imatengedwa bwino kuchokera m'matumbo am'mimba (GIT) ndikukumana ndi metabolism yokhala ndi carboxyl metabolite ndi ma metabolites ena osagwira. The dongosolo bioavailability wa losartan piritsi mawonekedwe pafupifupi 33%. Kuyerekeza kwakukulu kwa losartan ndi metabolite yake yogwira kumachitika pambuyo pa ola limodzi ndi maola atatu mpaka anayi, motsatana.

Biotransformation

Pafupifupi 14% ya losartan, akaperekedwa pakamwa, amasinthidwa kukhala metabolite yogwira. Kuphatikiza pa metabolite yogwira, metabolites yolimba imapangidwanso.

Chilolezo cha plasma cha losartan ndi metabolite yake yogwira ndi 600 ml / miniti ndi 50 ml / miniti, motsatana. Kuwonekera kwa impso kwa losartan ndi metabolite yake yogwira pafupifupi pafupifupi 73 ml / mphindi ndi 26 ml / miniti, motsatana. Ndi pakamwa makonzedwe a losartan, pafupifupi 4% ya mankhwalawa amachotsedwa mu mkodzo, ndipo pafupifupi 6% ya mlingoyo amamuthira mkodzo ngati metabolite yogwira. The pharmacokinetics of losartan ndi yogwira metabolite ikugwirizana ndi mkamwa makonzedwe a losartan potaziyamu mu Mlingo mpaka 200 mg.

Pambuyo pakamwa, kutsekemera kwa losartan ndi metabolite yake yogwira kumatsika kwambiri ndi theka lomaliza la pafupifupi maola 2 ndi maola 6 mpaka 9, motero. Mukamagwiritsidwa ntchito kamodzi patsiku la 100 mg, palibe kutchulidwa kwa losartan ndi metabolite yake yogwira m'madzi a m'magazi.

Losartan ndi metabolite yake yogwira imapukusidwa mu ndulu ndi mkodzo. Pambuyo pakukonzekera pakamwa, pafupifupi 35% ndi 43% amuchotsa mkodzo, ndipo 58% ndi 50% ndi ndowe, motero.

Njira yamachitidwe

Losartan ndi mankhwala opangira angiotensin II receptor antagonist (mtundu wa AT1) wogwiritsa ntchito pakamwa. Angiotensin II - wamphamvu vasoconstrictor - ndi mphamvu yogwira ya renin-angiotensin dongosolo ndipo imodzi mwazinthu zofunika kwambiri mu pathophysiology ya arterial hypertension. Angiotensin II imamangirira ma receptors a AT1, omwe amakhala m'mitsempha yosalala yamitsempha yamagazi, m'mitsempha ya adrenal, impso ndi mtima), kudziwa zotsatira zingapo zofunika zachilengedwe, kuphatikizapo vasoconstriction komanso kumasulidwa kwa aldosterone. Angiotensin II imapangitsanso kuchuluka kwa minofu yosalala.

Losartan amasankha mosamala AT1 receptors. Losartan ndi metabolacologic yogwira metabolite - carboxylic acid (E-3174) chipika mu vitro ndi mu vivo zonse zofunika kwambiri mwakuthupi za angiotensin II, posatengera komwe adachokera komanso njira ya kaphatikizidwe.

Losartan alibe agonistic effect ndipo satseka ma cell receptors ena kapena ma ion omwe akukhudzidwa ndi kayendetsedwe ka mtima. Komanso, losartan sikuletsa ACE (kininase II), puloteni yomwe imalimbikitsa kuwonongeka kwa bradykinin. Zotsatira zake, potentiation samayang'aniridwa kuti mwachitika zotsatira zoyipa zolumikizidwa ndi bradykinin.

Pogwiritsa ntchito losartan, kuchotsedwa kwa zoyipa zomwe zingasinthe ngati angiotensin II kukonzanso katulutsidwe kumabweretsa kuchuluka kwa ntchito ya plasma renin (ARP). Kuwonjezeka koteroko kumapangitsa kuti chiwopsezo cha angiotensin II chiwonjezeke. Ngakhale izi zikuwonjezeka, ntchito ya antihypertgency ndi kuchepa kwa kuchuluka kwa aldosterone m'magazi am'magazi kulimbikira, zomwe zikuwonetsa kutsekeka kwa mapangidwe a angiotensin II. Pambuyo pakutha kwa losartan, ntchito ya plasma renin ndi angiotensin II magawo atatu mkati mwa masiku atatu abwerere kuzomweku.

Onse losartan ndi metabolite yake yayikulu ali ndi mgwirizano wapamwamba kwambiri wa AT1 receptors kuposa AT2. Metabolite yogwira imakhala yogwira 10 mpaka 40 nthawi zambiri kuposa losartan (ikasinthidwa kukhala misa).

Lozap imachepetsa kwathunthu zotumphukira mtima (OPSS), kuchuluka kwa adrenaline ndi aldosterone m'magazi, kuthamanga kwa magazi, kuthamanga mu kufalikira kwa magazi m'magazi, kumachepetsa pambuyo pake, kumakhudzanso diuretic. Lozap imalepheretsa kukula kwa myocardial hypertrophy, kumawonjezera kulolerana kwa odwala omwe ali ndi vuto la mtima. Pambuyo pa limodzi la Lozap, mphamvu ya antihypertensive (kuchepa kwa magazi a systolic ndi diastolic) imakhala ikufika patatha maola 6, kenako imayamba kuchepa mkati mwa maola 24. Mphamvu yayitali kwambiri ya antihypertensive imakwaniritsidwa masabata 3-6 pambuyo poyambira kutenga Lozap.

Zotsatira za pharmacological zimawonetsa kuti kuchuluka kwa losartan mu plasma yamagazi mwa odwala omwe ali ndi vuto lodana ndi cirrhosis kumawonjezeka.

Zizindikiro zogwiritsidwa ntchito

Zisonyezo zogwiritsa ntchito mankhwalawa ndi:

Chithandizo cha matenda oopsa mu akulu
Chithandizo cha matenda a impso mu akulu odwala ochepa matenda oopsa ndi mtundu II matenda a shuga ndi proteinuria ≥0,5 g / tsiku monga gawo la antihypertensive mankhwala
kupewa kupewa matenda a mtima, kuphatikizapo kukomoka kwa odwala ochepa matenda oopsa ndi lamanzere lamitsempha yamagazi, kutsimikiziridwa ndi kafukufuku wa ECG
aakulu mtima kulephera (monga gawo la mankhwala,
tsankho kapena kusalephera kwa mankhwala ndi ACE zoletsa)

Mlingo ndi makonzedwe

Lozap amatengedwa pakamwa, ngakhale chakudya, kuchuluka kwa makonzedwe - 1 nthawi patsiku.

Ndi ochepa matenda oopsa, pafupifupi tsiku lililonse mlingo ndi 50 mg kamodzi patsiku. Mulingo wapamwamba wa antihypertensive umatheka pakadutsa masabata 3-6 chiyambireni chithandizo. Mwa odwala ena, kuwonjezera mlingo mpaka 100 mg patsiku (m'mawa) kungakhale kothandiza kwambiri.

Lozap ikhoza kutumikiridwa ndi mankhwala ena a antihypertensive, makamaka ndi okodzetsa (mwachitsanzo, hydrochlorothiazide).

Odwala omwe ali ndi matenda oopsa ndipo amalemba mtundu II shuga mellitus (proteinuria ≥0.5 g / tsiku)

Mulingo woyambira woyamba ndi 50 mg kamodzi tsiku lililonse. Mlingowo ungathe kuwonjezeka mpaka 100 mg kamodzi patsiku, kutengera ndi zomwe zimayambitsa kuthamanga kwa magazi mwezi umodzi atayamba chithandizo. Lozap ikhoza kugwiritsidwa ntchito ndi mankhwala ena a antihypertensive (mwachitsanzo, diuretics, calcium blockers blockers, alpha kapena beta receptor blockers, apakati akuchita mankhwala), komanso ndi insulin ndi mankhwala ena omwe amagwiritsidwa ntchito kwambiri a hypoglycemic (mwachitsanzo sulfonylurea, glitazone ndi glucosidase inhibitors).

Mlingo wa kulephera kwa mtima

Mlingo woyambirira wa losartan ndi 12,5 mg kamodzi patsiku. Nthawi zambiri, mankhwalawa amakhala osakanikirana pakatikati pa sabata (mwachitsanzo 12,5 mg kamodzi patsiku. 25 mg kamodzi patsiku. 50 mg kamodzi patsiku, 100 mg kamodzi patsiku) pa gawo lokhazikika la 50 mg imodzi kamodzi pa tsiku kutengera kulolera kwa odwala.

Kuchepetsa chiopsezo cha matenda opha ziwonetsero kwa odwala omwe ali ndi matenda oopsa komanso osagwirizana ndi mpweya wamanzere, wotsimikiziridwa ndi ECG

Mulingo woyambira woyamba ndi 50 mg wosachepera kamodzi patsiku. Kutengera kuchepa kwa kuthamanga kwa magazi, hydrochlorothiazide mu mlingo wotsika uyenera kuwonjezeredwa ku chithandizo ndipo / kapena mlingo wa Lozap uyenera kuchuluka mpaka 100 mg kamodzi patsiku.

Zotsatira zoyipa

Pa chithandizo ndi Lozap, odwala adakumana ndi zovuta zina chifukwa cha kulolera piritsi limodzi:

Kutupa kwa chiwindi, kuchuluka kwa hepatic transaminases,
Kuchulukitsa kwa magazi
Kukula kwa magazi m'thupi kuchepa magazi,
Kusowa kwa chakudya, nseru, pakamwa kowuma, nthawi zina kusanza komanso kusanza kwa tulo,
Kuchokera kwamanjenje - kusowa tulo, kusakwiya, kupweteka mutu, kuwonjezeka kwamanjenje, odwala omwe ali ndi vuto la kuchepa kwa mitsempha, pamakhala kuchuluka kwa mantha, kukhumudwa, kunjenjemera kwa malekezero.
Zotsatira zamatsenga - mawonekedwe a chotupa pakhungu, kukula kwa edema ya Quincke kapena anaphylaxis,
Kuwona m'maso, kusamva,
Kuchokera kumbali ya mtima ndi mitsempha yamagazi - kuchepa kwambiri kwa kuthamanga kwa magazi, kugwa, kupuma movutikira, tachycardia, kudetsa khungu m'maso, kukomoka, chizungulire,
Pa mbali ya kupuma dongosolo - kukula kwa yotupa njira ya chapamwamba kupuma thirakiti, chifuwa, bronchospasm, kuchuluka kwa mphumu bronchial, kuchuluka asthmatic,
Photosensitivity pakhungu.

Nthawi zambiri, Lozap imalekereredwa bwino, mavuto ake akudutsa ndipo safuna kuti mankhwalawo athe.

Contraindication

Mankhwala amatha kumwedwa pokhapokha mukaonana ndi katswiri. Musanayambe chithandizo, muyenera kuphunzira malangizo a mapiritsiwo, popeza Lozap ali ndi zotsutsana zotsatirazi:

Hypersensitivity kwa yogwira thunthu kapena kuyamwa mankhwala
kulephera kwambiri kwa chiwindi
mimba ndi mkaka wa m`mawere
ana ndi achinyamata ochepera zaka 18
mogwirizana ndi aliskiren odwala matenda a shuga

Zochita zamankhwala osokoneza bongo

Mankhwala ena a antihypertensive amatha kupititsa patsogolo zotsatira za Lozap. Kugwiritsa ntchito munthawi yomweyo ndi mankhwala ena omwe angapangitse kukhalapo kwa ochepa hypotension monga zovuta zomwe zimachitika (tricyclic antidepressants, antipsychotic, baclofen ndi amifostine) zingakulitse chiopsezo cha hypotension.

Losartan imapangidwa makamaka pogwiritsa ntchito pulogalamu ya cytochrome P450 (CYP) 2C9 kupita ku carboxylic acid metabolite yogwira. Pakafukufuku wazachipatala, zidapezeka kuti fluconazole (choletsa CYP2C9) amachepetsa kuwonetsa kwa metabolite yogwira pafupifupi 50%. Zinapezeka kuti munthawi yomweyo kugwiritsa ntchito mankhwala osokoneza bongo a losartan ndi rifampicin (olimbitsa ma enzymes a metabolic) kumapangitsa kutsika kwa 40% kutsitsa kwa metabolite yogwira m'madzi a m'magazi. Kukula kwa zamankhwala pazotsatira izi sikudziwika. Palibe kusiyana pakukhudzana ndi kugwiritsa ntchito nthawi imodzi kwa Lozap ndi fluvastatin (cholepheretsa CYP2C99 inhibitor).

Monga mankhwala ena omwe amatchinga angiotensin II kapena zotulukapo zake, kugwiritsa ntchito mankhwala komwe kumakhalabe ndi potaziyamu m'thupi (mwachitsanzo potaziyamu woteteza potaziyamu: spironolactone, triamteren, amiloride), kapena kuonjezera kuchuluka kwa potaziyamu (mwachitsanzo heparin) komanso zakudya zowonjezera potaziyamu kapena mchere wotsekemera, zimatha kuyambitsa kuchuluka kwa seramu potaziyamu. Kugwiritsa ntchito ndalama ngati imeneyi sikulimbikitsidwa.

Kuwonjezereka kosintha kwa seramu lifiyamu, komanso kawopsedwe, zanenedwa ndikugwiritsa ntchito munthawi yomweyo lifiyamu ndi ACE inhibitors. Komanso milandu yokhudzana ndi kugwiritsidwa ntchito kwa angiotensin II receptor antagonists sinanenedwe kwambiri kawirikawiri. Chithandizo chogwirizana ndi lithiamu ndi losartan ziyenera kuchitika mosamala. Ngati kugwiritsa ntchito kuphatikiza koteroko kumaganiziridwa kuti ndikofunikira, ndikulimbikitsidwa kuti mupeze kuchuluka kwa ma seramu pa nthawi yomweyo.

Pogwiritsa ntchito munthawi yomweyo ma angiotensin II okana mankhwala osagwiritsa ntchito mankhwala osokoneza bongo (mwachitsanzo, kusankha ma cycloo oxygenase-2 inhibitors (COX-2), acetylsalicylic acid mu Mlingo womwe umakhala ndi zotsutsana ndi zotupa, ma NSAIDs osasankha), mphamvu ya antihypertgent imatha kufooka. Kugwiritsa ntchito nthawi yomweyo kwa angiotensin II okondwerera kapena okodzetsa omwe ali ndi NSAIDs kungakulitse chiwopsezo cha ntchito yaimpso, kuphatikizapo kukula kwa kulephera kwaimpso, komanso kuwonjezeka kwa kuchuluka kwa serum potaziyamu, makamaka kwa odwala omwe ali ndi vuto laimpso. Kuphatikiza uku kuyenera kuyikidwa mosamala, makamaka kwa okalamba. Odwala akuyenera kudutsa hydrate yoyenera, komanso akuyenera kuwunikira ntchito ya impso pambuyo poyambira kulumikizana, ndipo nthawi ndi nthawi.

Hypersensitivity

Angioneurotic edema. Odwala omwe ali ndi mbiri ya edema ya angioneurotic (edema ya nkhope, milomo, pakhosi, ndi / kapena lilime) ayenera kuwunikidwa nthawi zambiri.

Arterial hypotension ndi kusowa kwa madzi mu electrolyte

Zizindikiro zamitsempha yama hypotension, makamaka pambuyo pa kumwa koyamba kwa mankhwalawo kapena atatha kuchuluka kwa mankhwalawa, zimatha kupezeka mwa odwala omwe ali ndi kuchepa kwa magazi mkati komanso / kapena kuchepa kwa sodium, komwe kumachitika chifukwa chogwiritsa ntchito diuretics yamphamvu, kuletsa zakudya zamafuta amchere, kutsekemera kapena kusanza. Musanayambe chithandizo ndi Lozap, kuwongolera koteroko kuyenera kuchitika kapena mankhwalawa agwiritsidwe ntchito kochepa.

Electrolyte kusalinganika

Electrolyte kusalinganika nthawi zambiri kumawonedwa kwa odwala omwe ali ndi vuto la Impso (omwe ali ndi vuto losakanizira la shuga), lomwe liyenera kukumbukiridwa. Odwala omwe ali ndi mtundu wachiwiri wa matenda a shuga komanso nephropathy, matenda a hyperkalemia anali apamwamba pagulu la Lozap kuposa gulu la placebo. Chifukwa chake, nthawi zambiri muyenera kuwunika kuchuluka kwa potaziyamu m'magazi a plasma ndi chilolezo cha creatinine, makamaka odwala omwe ali ndi vuto la mtima ndi chilolezo chaininine 30 - 50 ml / miniti.

Kugwiritsa ntchito munthawi yomweyo mankhwala a Lozap ndi potaziyamu - osungira okodzetsa, zowonjezera za potaziyamu komanso zina zokhala ndi mchere zomwe zili ndi potaziyamu sizikulimbikitsidwa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Kupangidwa mu mawonekedwe a mapiritsi, omwe amaphatikizidwa ndi filimu yoyera ya 12,5 mg, 50 mg ndi 100 mg. Oblong, mapiritsi a biconvex. Matumba okhala ndi mapiritsi 10 a ma PC. wogulitsidwa makatoni okhala ndi 30, 60, 90 ma PC.

Kapangidwe ka mankhwala Lozap kumaphatikizapo losartan potaziyamu (yogwira pophika), povidone, microcrystalline cellulose, croscarmellose sodium, mannitol, magnesium stearate, hypromellose, talc, macrogol, utoto wachikasu, dimethicone (excipients).

Mapiritsi a Lozap kuphatikiza (pamodzi ndi hydrochlorothiazide diuretic kuti apititse patsogolo), yogwira zinthu, losartan ndi hydrochlorothiazide.

Makhalidwe

Mankhwala a antihypertensive - osagwiritsa ntchito peptide blocker of receptors AT2, amatchinga mpikisano wa subtype AT1. Mwaletsa ma receptors, Lozap amalepheretsa kumangiriza kwa angiotensin 2 mpaka AT1 receptors, zomwe zimapangitsa zotsatirazi za AT2 zomwe zimayendetsedwa: matenda oopsa, kutulutsa kwa renin ndi aldosterone, catecholamines, vasopressin, ndi kukula kwa LVH. Mankhwalawa satchinjiriza eniotensin-yotembenuza enzyme, zomwe zikutanthauza kuti sizikhudza dongosolo la kinin ndipo sizitsogolera pakuphatikizika kwa bradykinin

Lozap amatanthauza mankhwala opatsirana, chifukwa metabolite yake yogwira (metabolite ya carboxylic acid), yopangidwa nthawi ya biotransfform, imakhala ndi antihypertensive.

Pambuyo pa limodzi mlingo, antihypertensive zotsatira (kuchepa kwa magazi a systolic ndi diastolic) zimafika pazitali pambuyo pa maola 6, kenako zimayamba kuchepa mkati mwa maola 24. Mulingo wambiri wa antihypertensive umatheka pakatha masabata 3-6 mankhwala atayamba.

Malangizo ogwiritsira ntchito

Lozap amatengedwa pakamwa, palibe kudalira chakudya. Mapiritsi ayenera kumwedwa kamodzi patsiku. Odwala ochepa matenda oopsa amatenga mankhwala a 50 mg patsiku. Kuti mukwaniritse zowoneka bwino, nthawi zina mlingo umakulitsidwa mpaka 100 mg. Momwe mungatengere Lozap pankhaniyi, adokotala amapereka malingaliro payekha.

Malangizo a Lozap N amapereka kuti odwala omwe ali ndi vuto la mtima amwe mankhwala a 12,5 mg kamodzi patsiku. Pang'onopang'ono, mlingo wa mankhwalawa umachulukitsidwa pakapita sabata imodzi mpaka pamenepo, mpaka ifike 50 mg kamodzi patsiku.

Malangizo ogwiritsira ntchito Lozap Plus amaphatikizapo kumwa piritsi limodzi kamodzi patsiku. Mlingo waukulu kwambiri wa mankhwalawa ndi mapiritsi 2 patsiku.

Ngati munthu atenga mlingo waukulu wa mankhwala a diuretic nthawi yomweyo, mlingo wa Lozap wa tsiku ndi tsiku umachepetsedwa mpaka 25 mg.

Okalamba ndi odwala omwe ali ndi vuto la impso (kuphatikiza omwe ali ndi hemodialysis) safunika kusintha mlingo.

Zotsatira zoyipa

Zosiyanasiyana zoyipa zimachitika: zotupa pakhungu, angioedema, anaphylactic. Ndikothekanso kuchepetsa kuthamanga kwa magazi, kufooka, chizungulire. Osowa kwambiri, chiwindi, migraine, myalgia, zizindikiro za kupuma, kukanika, chiwindi.

Zizindikiro za bongo ndi hypotension, tachycardia, koma bradycardia ndiyothekanso. Chithandizo cha mankhwalawa ndikuchotsa mankhwalawa mthupi ndikuchotsa zofunikira za bongo.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Osamamuchitira Lozap panthawi yoyembekezera. Pa mankhwala lachiwiri ndi lachitatu trimesters ndi mankhwala omwe amakhudzanso renin-angiotensin, zolakwika mu chitukuko cha mwana wosabadwayo ndipo ngakhale imfa ingachitike. Mimba ikangochitika, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.

Ngati lozap iyenera kutengedwa panthawi yoyamwa, kuyamwitsa kuyenera kuyimitsidwa nthawi yomweyo.

Kutenga ana?

Mphamvu yakuwonetsedwa komanso chitetezo cha ana sichinakhazikitsidwe, chifukwa chake, mankhwalawa sagwiritsidwa ntchito pochiza ana.

Zofananira zonse pazogwira ntchito:

Blocktran
Brozaar
Vasotens,
Vero-Losartan,
Zisakar
Cardomin Sanovel,
Karzartan
Cozaar
Nyanja
Lozarel
Losartan
Losartan potaziyamu,
Lorista
Losacor
Presartan
Renicard.

Posankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Lozap, mtengo ndi kuwunika kwa mankhwala omwe ali ndi zotsatira zofananira sizikugwira ntchito. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Lozap kapena Lorista - ndibwino?

Zomwe zimagwiritsidwa ntchito mu mankhwala a Lorista ndizofanana ndi ku Lozap. Lorista amaperekedwa kwa odwala omwe ali ndi matenda oopsa komanso osakhazikika mtima. Nthawi yomweyo, mtengo wa mankhwala a Lorista ndi wotsika. Ngati mtengo wa Lozap (30 ma PC.) Uli ngati ma ruble 290, ndiye kuti mtengo wamapiritsi 30 a mankhwala a Lorista ndi ma ruble 140. Komabe, mutha kugwiritsa ntchito analogue pokhapokha mukaonana ndi dokotala komanso ngati mawu ake awerengedwa.

Kodi pali kusiyana kotani pakati pa Lozap ndi Lozap Plus?

Ngati mukufunika kuthandizidwa ndi mankhwalawa, funso nthawi zambiri limakhala, lomwe ndi labwino - Lozap kapena Lozap Plus?

Mukamasankha mankhwala, ziyenera kudziwika kuti pakupanga kwa Lozap Plus, losartan ndi hydrochlorothiazide amaphatikizidwa, omwe ndi okodzetsa ndipo ali ndi mphamvu yoletsa thupi. Chifukwa chake, mapiritsi awa akuwonetsedwa kwa odwala omwe amafunikira chithandizo chamankhwala.

Malangizo apadera

Odwala omwe amachepetsa magazi mozungulira (pafupipafupi chifukwa chogwiritsa ntchito kwambiri mankhwala okodzetsa), Lozap ® amatha kupangitsa kuti matenda azikhala ndi matenda oopsa kwambiri. Chifukwa chake, musanayambe chithandizo ndi mankhwalawa, ndikofunikira kuti muchepetse kuphwanya komwe, kapena kumwa mankhwalawa.

Odwala omwe ali ndi vuto lachiwindi cha chiwindi (mawonekedwe ofatsa kapena olimbitsa) atatha kugwiritsa ntchito othandizira ena, kuchuluka kwa gawo lomwe limagwira ndipo metabolite yake yogwira ndi yayitali kuposa mwa anthu athanzi. Pankhaniyi, munthawi iyi, komanso pakachitika mankhwala, Mlingo wotsika umafunika.

Mu vuto la impso, kukanika kwa hyperkalemia (kuchuluka kwa ndende ya potaziyamu m'magazi) ndikotheka. Chifukwa chake, munthawi ya chithandizo, mukuyenera kuwunika pafupipafupi kuchuluka kwa mphamvu iyi.

Ndi munthawi yomweyo makonzedwe a mankhwala omwe amakhudzanso renin-angiotensin dongosolo la odwala aimpso stenosis (osakwatiwa kapena awiri mbali), serum creatinine ndi urea achuluke. Mukamaliza kumwa mankhwalawo, matendawo nthawi zambiri amakhazikika. Pankhaniyi, ndikofunikira kuyang'anitsa pafupipafupi labotale kuchuluka kwa mapangidwe amomwe am'magawo a impso.

Zambiri zokhudzana ndi Lozap pa kuyendetsa galimoto kapena kugwira ntchito zomwe zimafunikira chidwi chachikulu ndi kuthamanga kwa zochitika zama psychomotor sizinadziwikebe.

Kuyanjana kwa mankhwala osokoneza bongo

Mankhwala amatha kutumikiridwa ndi ena othandizira. Kulimbikitsana komwe kumachitika chifukwa cha ma beta-blockers ndi sympatholytics kumawonedwa. Ndi kuphatikiza kwa losartan ndi okodzetsa, zowonjezera zimawonedwa.

Palibe kuyanjana kwa pharmacokinetic wa losartan ndi hydrochlorothiazide, digoxin, warfarin, cimetidine, phenobarbital, ketoconazole ndi erythromycin adadziwika.

Rifampicin ndi fluconazole akuti amachepetsa kuchuluka kwa yogwira metabolites wa losartan m'madzi am'magazi. Kukula kwakukhalirana kwa kudalirana kumeneku sikumadziwikabe.

Monga othandizira ena omwe amalepheretsa angiotensin 2 kapena magwiridwe ake, kuphatikiza kwa losartan ndi potaziyamu wotsekemera okodzetsa (mwachitsanzo, spironolactone, triamteren, amiloride), kukonzekera kwa potaziyamu ndi mchere wokhala ndi potaziyamu kumawonjezera chiopsezo cha hyperkalemia.

NSAIDs, kuphatikizapo kusankha ma inhibitors a COX-2, amachepetsa mphamvu ya okodzetsa ndi mankhwala ena a antihypertensive.

Pogwiritsa ntchito angiotensin 2 ndi ma lithium receptor antagonists, kuwonjezeka kwa plasma lithiamu ndende ndikotheka. Popeza izi, ndikofunikira kuyesa maubwino ndi zoopsa za mgwirizano wa lospan ndi kukonzekera kwa mchere wa lithiamu. Ngati kugwiritsidwa ntchito kophatikizana ndikofunikira, kuchuluka kwa lifiyamu m'madzi a m'magazi kuyenera kuyang'aniridwa pafupipafupi.

Kodi ndemanga zikuyankhula chiyani?

Ndemanga pa Lozap Plus ndi Lozap zikuwonetsa kuti nthawi zambiri, mankhwalawa amachepetsa kuthamanga kwa magazi ndipo amathandizira anthu omwe ali ndi matenda a mtima.

Odwala omwe amapita pagawo lodziwika kuti asiye ndemanga pa Lozap 50 mg amazindikira kuti kutsokomola, pakamwa pouma, komanso kuwonongeka kwa khutu nthawi zina kumadziwika ngati mavuto. Koma pazonse, ndemanga za odwala pamankhwala abwino.

Nthawi yomweyo, kuwunika kwa madotolo kukuwonetsa kuti mankhwalawa sangakhale oyenera kwa anthu onse omwe ali ndi vuto loipa lamankhwala. Chifukwa chake, poyamba ziyenera kutengedwa moyang'aniridwa ndi katswiri.

Kuwonongeka kwa chiwindi

Poganizira za pharmacokinetic data yomwe ikuwonetsa kuwonjezeka kwakukulu kwa kuchuluka kwa lozap mu plasma yamagazi mwa odwala omwe ali ndi chiwindi, mbiri yotsika ya kuchuluka kwa mankhwalawa kwa odwala omwe ali ndi vuto la chiwindi liyenera kuganiziridwa. Mankhwala a Lozap sayenera kugwiritsidwa ntchito mwa odwala omwe ali ndi vuto la chiwindi kwambiri chifukwa chosadziwa zambiri.

Matenda aimpso

Zosintha mu ntchito ya aimpso, kuphatikiza kulephera kwa aimpso, komwe kumalumikizidwa ndi kulepheretsa kwa dongosolo la renin-angiotensin zalembedwa (makamaka kwa odwala omwe ali ndi vuto la aimpso-angiotensin-aldosterone, i.e. odwala omwe ali ndi vuto la mtima kapena kuwonongeka kwa aimpso). Monga mankhwala ena omwe amakhudza dongosolo la renin-angiotensin-aldosterone, kuchuluka kwa urea ndi misempha ya serum creatinine akuti kwa odwala omwe ali ndi vuto limodzi la impso. Kusintha uku kwa impso kumatha kusinthanso pambuyo pakuchotsa kwamankhwala. Muyenera kusamala mukamagwiritsa ntchito Lozap odwala omwe ali ndi vuto la mtima lamitsempha kapena ngati stenosis yamitsempha yama impso imodzi.

Kugwiritsa ntchito limodzi kwa Lozap ndi ACE zoletsa kumapangitsa kuti impso zikule kwambiri, chifukwa chake kuphatikizidwa sikulimbikitsidwa.

Kulephera kwa mtima

Monga mankhwala ena omwe amakhudzanso dongosolo la renin-angiotensin, odwala omwe ali ndi vuto la mtima komanso / opanda vuto laimpso, pamakhala chiwopsezo cha matenda oopsa komanso (nthawi zambiri amakhala ndi vuto laimpso.

Palibe chithandizo chokwanira pakugwiritsa ntchito Lozap odwala omwe ali ndi vuto la mtima komanso ofanana ndi aimpso, omwe ali ndi vuto la mtima (IV kalasi molingana ndi NYHA), komanso odwala omwe ali ndi vuto la mtima komanso chizindikiro cha mtima. Chifukwa chake, Lozap iyenera kugwiritsidwa ntchito mosamala m'gululi la odwala. Chenjezo limalangizidwa kugwiritsa ntchito Lozap ndi beta-blockers nthawi yomweyo.

Stenosis ya maortic ndi mitral maalves, oletsa hypertrophic cardiomyopathy.

Monga ndi vasodilators ena, mankhwalawa amadziwitsidwa ndi chisamaliro chapadera kwa odwala aortic ndi mitral valve stenosis kapena choletsa hypertrophic cardiomyopathy.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Lozap sayenera kutumikiridwa panthawi yapakati. Ngati chithandizo ndi losartan sichofunikira, ndiye kuti odwala omwe akukonzekera kutenga pakati ayenera kupatsidwa mankhwala ena a antihypertensive omwe ali otetezeka panthawi yapakati. Ngati muli ndi pakati, chithandizo cha Lozap chiyenera kuyimitsidwa pomwepo ndipo njira zina zochiritsira magazi ziyenera kugwiritsidwa ntchito kuwongolera kuthamanga kwa magazi.

Popereka mankhwala pakupatsa mkaka, lingaliro liyenera kuperekedwa kuti muchepetse kuyamwitsa kapena kusiya kulandira chithandizo ndi Lozap.

Zodabwitsa zakuthwa kwa mankhwalawa poyendetsa magalimoto kapena njira zina zowopsa

Palibe kafukufuku yemwe adachitapo pankhani yokhudza kuyendetsa magalimoto ndi kugwira ntchito ndi makina. Komabe, mukamayendetsa magalimoto ndikugwiritsa ntchito njira, munthu ayenera kukumbukira kuti akumwa mankhwala a antihypertensive, chizungulire kapena kugona kugona nthawi zina kumatha kuchitika, makamaka kumayambiriro kwa chithandizo kapena pamene mlingo ukuwonjezeka.

Bongo

Ndi kuwonjezeka kwa mlingo woyenera kapena osagwiritsa ntchito mankhwalawa kwa nthawi yayitali, odwala amakhala ndi vuto la mankhwala osokoneza bongo omwe amafotokozedwa pakuwonjezereka kwa zovuta zomwe tafotokozazi komanso kuchepa kwakukulu kwa magazi. Kuphatikiza apo, chifukwa cha kuchuluka kwa madzi am'madzi ndi michere yaying'ono kuchokera mthupi, kusowa kwa madzi mu electrolyte kumayamba.

Ndi chitukuko cha zizindikiro zamatenda zotere, chithandizo ndi Lozap chimayimitsidwa nthawi yomweyo ndipo wodwala amatumizidwa kwa dokotala. Wodwalayo akuwonetsedwa zam'mimba (zothandiza ngati mankhwalawa adatengedwa posachedwa), kuyang'anira matenda am'mimba mkati ndikuwonetsa chithandizo - kuthetseratu madzi am'mimba, kubwezeretsa kuchuluka kwa mchere mthupi, kusintha kwachulukidwe ka magazi ndi mtima ntchito.