Zaka zaposachedwa, asayansi afika pakukhulupirira kuti ukalamba ndi matenda chabe omwe amatha kuchiritsidwa. Mankhwala aliwonse a pharmacological amapita kafukufuku osati pazomwe amafuna, komanso pa anti-kukalamba. Pali mankhwala ambiri padziko lapansi omwe amatha kutalikitsa moyo wa munthu, ndipo imodzi mwa izo ndi Metformin, yopangidwa ndi asayansi aku Russia zaka zoposa 60 zapitazo. Ndiye kodi imatenga nthawi yayitali bwanji?

Kukonzanso mphamvu kwa metformin

Chithandizo chogwira mankhwalawa ndi metformin hydrochloride, yomwe imapangitsa kuchepetsa kukalamba kwa munthu.

Metformin poyambilira anafuna kuchiritsa matenda ashuga amtundu wa 2. Zinapezeka ndi asayansi aku Russia zaka 60 zapitazo. Kuyambira pamenepo, zambiri zalandiridwa pokhudzana ndi njira zake zothandizira pochiritsa. Anthu omwe ali ndi matenda ashuga omwe amamwa mankhwala a metformin adakhala nthawi yayitali 25% kuposa omwe alibe matendawa. Izi zimapangitsa asayansi kuphunzira mankhwalawa ngati njira yotalikitsira moyo.

Masiku ano, maphunziro angapo a metformin monga mankhwala ochiritsira okalamba akuchitika padziko lonse lapansi. Makamaka, mu 2005 ku Oncology Research Institute yotchedwa N.N. Petrova, kafukufuku adachitika mu labotale kuti aphunzire za ukalamba ndi carcinogenesis, zomwe zimawonetsa kuti metformin imatalikitsa moyo. Zowona, kuyesaku kunachitika kokha pa nyama. Kuphatikizanso kwina, chifukwa cha kafukufukuyu, kudapeza kuti chinthucho chimatetezanso nyama ku khansa.

Pambuyo pa kafukufukuyu, gulu lonse la asayansi padziko lonse lapansi lidachita chidwi ndi zochita za metformin. Kuchokera nthawi imeneyo, kafukufuku wambiri wachitika omwe amatsimikizira zotsatira za kuyesa kwa 2005.

Zofunika! Mothandizidwa ndi anthu omwe amamwa mankhwalawo Zinapezeka kuti mutatenga chinthu, chiopsezo chokhala ndi oncology chimachepetsedwa ndi 25-40%.

Mu malangizo ogwiritsira ntchito, simukuwona mawu omwe akuwonetsa mphamvu ya mankhwalawa pakukulitsa moyo. Koma, izi zimachitika kokha chifukwa chakuti ukalamba mwalamulo sunazindikiridwe ngati matenda.

Kodi metformin imakhudza bwanji thupi?

Kutulutsidwa kwamitsempha yamagazi kuchokera ku cholesterol plaques. Izi zimabweretsa kuti ntchito yofananira ya kuzungulira kwa dongosolo, imalepheretsa thrombosis ndi vasoconstriction. Mphamvu iyi ya mankhwalawa imathandizira kukulitsa unyamata wamtima mu mtima. Amadziwika kuti kuchuluka kwakukulu kwaimfa kumachitika chifukwa cha matenda amdongosolo lino.

Zimatsimikiziridwa kuti metformin imaletsa kukula kwa matenda a senile.

Kuwongolera kagayidwe kake ndikuwonjezera kuchuluka kwa cholesterol yopindulitsa ndikuchepetsa kuvulaza. Momwemo, pali kagayidwe koyenera m'thupi. Mafuta amamwetsedwa molondola, pamakhala pang'onopang'ono, osautsa, wotaya mafuta owonjezera ndi kulemera. Zotsatira zake, katundu pamakina onse ofunikira amachepetsedwa. Ngati, nthawi yomweyo akamamwa mankhwalawo, munthu amayamba kusintha moyo wake, zotsatira za mankhwalawo zimawonjezeka.

Anachepetsa chilako. Chinsinsi cha moyo wautali ndi kuwonda. Izi ndiye zowona. Metformin imathandizira kukwaniritsa ntchito iyi mwa kupondereza chilakolako chofuna kudya.

Kuchotsa shuga m'magazi am'mimba. Kutha kwa shuga kuthamangitsa njira zogwirizanirana zama mamolekyulu a protein kumathandizira kukalamba msanga komanso kumatenda ambiri.

Kuwongolera magazi. Kuchita izi kumachepetsa chiwopsezo cha kuundana kwa magazi, sitiroko komanso mtima. Matendawa akutsogolera mndandanda wazomwe zimayambitsa kufa msanga.

The zikuchokera mankhwala

• lilac
• muzu wa mbuzi
• talcum ufa
• magnesium wakuba,
• kukhuthala
• titanium dioxide
• crospovidone
• povidone K90,
• macrogol 6000.

Chofunikira chachikulu pakuphatikizidwa kwa mankhwalawo ndi metformin hydrochloride, yopangidwa kuchokera ku zinthu zachilengedwe zofunikira: lilac ndi muzu wa mbuzi. Komanso, mankhwalawa ali ndi zovuta zina zowonjezera, makamaka talc, magnesium stearate, titanium dioxide ndi omwe adalembedwa pamwambapa.

Malangizo a kumwa mankhwala

Kuti mugwiritse ntchito metformin kuti muchepetse kukalamba, muyenera kumwa mankhwalawa pa theka la mankhwalawo omwe akuwonetsa mu malangizo omwe angagwiritsidwe ntchito. Mankhwala othandizira amapatsidwa mankhwalawa. Koma, munthu wathanzi akamagwiritsa ntchito mankhwala amenewa, amatha kuvulaza kuposa zabwino.

Zofunika! Musanaganize zogwiritsira ntchito metformin, kuunika kwathunthu ndikofunikira. Izi ndizofunikira kuti muchepetse chiopsezo cha zotsatira zoyipa ndikuwona mulingo wa prophylactic.

Kugwiritsa ntchito mankhwalawa ngati anti-okalamba, ziwonetsero izi ziyenera kukumbukiridwa:

1. zaka siziyenera kupitirira zaka 30, koma osapitirira 60,
2. kunenepa kwambiri komanso kunenepa kwambiri,
3. mafuta a cholesterol ndi / kapena shuga ndi apamwamba kuposa abwinobwino.

Mlingo woyenera uyenera kuthandizidwa ndi dokotala ndikufotokozera momwe mungagwiritsire metformin. Kuti mumve, tikulimbikitsidwa kuti musatenge oposa 250 mg a metformin patsiku.

Ndi metformin iti yomwe ndiyabwino kupangidwanso?

Metformin imapangidwa pansi pa malonda osiyanasiyana ndipo amapangidwa ndi makampani ambiri:

• Metformin
• Glycon
• Metospanin
• Siofor
• Glucophagus,
• Glformin ndi ena.

Malo otetezeka komanso ovomerezeka kwambiri ku America, Russia ndi mayiko ena 17 aku Europe ndi Glucofage. Amaloledwa kutenga ngakhale ana azaka 10. Zimatsimikiziridwa kuti ndi Glucophage yomwe imayambitsa zotsatira zoyipa zochepa, ndipo poletsa kukalamba amakhala otetezeka pafupifupi 100%.

Komabe, ndikofunikira kufunsa dokotala za mankhwala omwe mungamwe metformin.

Zotsatira zoyipa

Ngati mukumwa mankhwala ochepetsedwa, ndiye kuti palibe mavuto omwe amayenera kuchitika. Komabe, ndichabwino kuwatchula:

1. chitsulo
2. kukomoka
3. matumbo (matumbo),
4. kudzimbidwa (kusanza, nseru),
5. kuchepa magazi (ngati simumalandira vitamini B12 ndi folic acid),
6. lactic acidosis.

Yang'anani! Ngati munthu adalemedwa kwambiri kapena sanadye asanagwiritse ntchito metformin, shuga ya magazi imatha kutsika. Zizindikiro: kugwedeza dzanja, kufooka, chizungulire. Pankhaniyi, muyenera kudya kena kokoma.

Kodi Malysheva akuti chiyani za mankhwalawa?

Malysheva amalankhula za metformin mwatsatanetsatane mu pulogalamu yake ya "Health", pomwe amakafotokozera nkhaniyi pogwiritsa ntchito mankhwalawa pobwezeretsa. Gulu la akatswiri limatenganso mbali mu pulogalamuyi, yomwe imapereka mayankho ku mafunso ambiri okhudzana ndi machitidwe ndi mawonekedwe a mankhwalawo.

Metformin ndi mankhwala omwe amadziwika ndi matenda a shuga a 2.

Metformin ndi m'gulu la mankhwala omwe amatchedwa biguanides.

Metformin imathandiza odwala omwe ali ndi matenda a shuga a 2 kuwongolera kuchuluka kwa glucose, amachepetsa mayamwidwe azakudya ndi kaphatikizidwe m'chiwindi. Mankhwalawa amathandizanso chidwi chachilengedwe cha maselo kuti apange insulin.

Kafukufuku wambiri akuwonetsa kuti mapindu a metformin sakhala ndi izi. Mu 2010, Medical News Today idafotokoza kafukufuku awiri yemwe adawonetsa kuthekera kwa Metformin kuteteza omwe amasuta ku khansa ya m'mapapo. Ndipo mu 2012, zidapezeka kuti metformin ikhoza kukhala yothandiza pochiza khansa ya kapamba.

Tsopano gulu lofufuzira la University of Katolika ya Leuven (Katholieke Universiteit Leuven) ku Belgium lawonetsa kuti metformin ikhoza kuletsa ukalamba ndikupatsa moyo wautali.

Kuyesera kwa Roundworm

"Akamakula, nyongolotsi zazing'ono zimayamba kuchepa, ndikuyamba kuyenda pang'ono. Koma nyongolotsi zomwe tidapereka metformin zikuwonetsa kuchepa kochepa kwambiri ndipo sikununkha. Sikuti amakula pang'onopang'ono, amakhalanso athanzi kwa nthawi yayitali, "akutero a Haes, wolemba kafukufukuyu.

Koma kodi metformin imagwira ntchito bwanji? Gululi likufotokozera kuti maselo m'thupi lathu amalandila mphamvu kuchokera ku mitochondria - "michere yamphamvu kwambiri" yomwe imapanga magetsi ofooka kwambiri mkati mwa selo lililonse. Njirayi imayendera limodzi ndi kupanga mitundu yambiri ya okosijeni (ma radicals).

Ma mamolekyulu oterewa amatha kukhala owopsa kwa thupi. Amatha kuwononga mapuloteni ndi ma DNA, kusokoneza magwiridwe antchito a maselo. Koma asayansi amati mutayang'ana pang'ono, mamolekyuwo amatha kukhala othandiza.

"Malingana ngati kuchuluka kwa molekyu yoopsa yomwe ilimo mu maselo ikhale yocheperako, izi zimathandizira pakukula kwa maselo. Maselo amagwiritsa ntchito ma molekyulu othandizira kuti asapweteke ena. Metformin imayambitsa kuwonjezeka pang'ono kwa chiwerengero cha mamolekyulu amenewo. Tikhulupirira kuti izi zimapangitsa kuti maselowo akhale olimba komanso kuti azikhala ndi nthawi yambiri yochezera, ”akufotokoza a Haes.

Ma Antioxidants Angayanjane ndi Metformin

Komabe, ofufuzawo anachenjeza kuti ma antioxidants amatha kusintha momwe anti-kukalamba amakhudzidwira, chifukwa, m'malingaliro awo, mamolekyulu "oyipirawo" pamlingo wina wake ayenera kupezeka m'maselo athu.

Ngakhale zotsatira zoyesedwa ngati zowoneka mozungulira zikuwoneka bwino, Haes amalimbikitsa kufufuza kwina kuti: "Tiyenera kusamala ndi momwe zotsatirazi zimasinthidwira kwa anthu. Koma kafukufuku wathu ayenera kukhala maziko abwino pantchito ina mtsogolo. "

Mwa njira, sizokhazo zowerengeka zomwe zawonetsa kuthekera kwamphamvu kwa metformin. Chaka chatha, ogwira ntchito ku National Institute of Aging (NIA) adapeza kuti metformin imawonjezera moyo wa labotale ndi mbewa pafupifupi 5.83% poyerekeza ndi gulu loyang'anira.

Mwamtheradi aliyense amalota kukhala ndi moyo komanso kukhala wachichepere kwa nthawi yayitali. M'mbuyomu, machiritso okalamba amatha kupezeka m'mabuku. Masiku ano, mankhwala ngati amenewo ndi enieni. Kodi zimathandizanso kutalikitsa moyo? Mutha kupeza yankho la funsoli m'nkhani yathu.

Kapangidwe ka mankhwala. Zambiri zamankhwala

Ndi anthu ochepa omwe amadziwa, koma chaka chino zidadziwika kuti asayansi adapanga njira yothandizira kukalamba. Kukula kwa mankhwalawa ndi kwa akatswiri a Yunivesite ya Altai. Asayansi akuti mankhwalawa amathandizira kubwezeretsa maselo omwe ali ndi vuto lothandizira thupi lonse. Mukamagwiritsa ntchito mankhwala atsopano, kukalamba kumachepa kwambiri.

Asayansi a Altai adapanga mankhwala ochiritsira okalamba sizabwino. Masiku ano, munthu aliyense wachiwiri padzikoli akuyesetsa kukhalabe ndi thanzi ndi unyamata m'njira iliyonse. Atolankhani a Russian Federation adawona kuti mu February chaka chino, mankhwala omwe amachepetsa kukalamba adadutsa kale gawo lachiwiri loyesa. Mwinanso posachedwa titha kuwona machiritso okalamba pamashelefu amitundu yonse. Ndikofunika kudziwa kuti mankhwalawa ali ndi kuphatikiza kwakukulu. Malinga ndi asayansi a Altai, mankhwalawa samakhudzanso mphamvu ya munthu komanso chitetezo cha m'thupi. Pazifukwa izi, mankhwalawa alibe vuto lililonse. Ndizofunikanso kudziwa kuti kuchiritsa kwa ukalamba kumapangitsa kuti maselo atsopano akhale m'thupi la munthu.

Elena Malysheva ndi mankhwala ochepetsa ukalamba

Kanema wawayilesi "Live wathanzi!", Wopangidwa ndi a Elena Malysheva, ndiotchuka kwambiri pakati pa omwe amayang'anira thanzi lawo mosamala. Chaka chino, pulogalamu yapa kanema wawayilesiyi idaphunzira mankhwala kuyambira ukalamba. Mutha kudziwa zambiri za iwo m'nkhaniyi.

Mankhwala okalamba kuchokera ku Malysheva amakulolani kubwezeretsa maselo amthupi. Mankhwala oyamba ndi zoletsa. Mankhwala oterowo sangathandize kuti mukhale achichepere kutalika, komanso kukonza mtima wamitsempha yamagazi. Mankhwalawa ndi monga Captopril, Ramipril ndi ena. Ndizofunikanso kudziwa kuti amachepetsa chiopsezo cholephera mtima.

Mankhwala atakalamba kuchokera ku Malysheva, malinga ndi wowonera TV, amatha kuthana ndi matenda ambiri. Mankhwala oterowo ndi Aspirin. Chifukwa cha mankhwalawa, chiopsezo cha kuwonongeka magazi, mikwingwirima ndi matenda a mtima amachepa. Monga lamulo, aspirin amaperekedwa kwa anthu azaka zopitilira 40.

Mankhwala omwe Elena Malysheva adalimbikitsa mu pulogalamu yake yapa kanema amathandizanso kukhala ndi thupi labwino komanso amachepetsa chiopsezo cha matenda oopsa. Musanagwiritse ntchito mankhwala aliwonse, timalimbikitsa kufunsa dokotala.

Kodi zotsatira za mankhwala a Altai zidayesedwa bwanji?

Monga tanena kale, asayansi a Altai apanga njira ina yothana ndi ukalamba. Pakadali pano, wadutsa magawo awiri oyesedwa. Mu Novembala chaka chino, akatswiri akukonzekera kuyamba kuyesa odzipereka.

Pachiyeso choyambirira, machiritso okalamba adayesedwa pazinyama, zomwe ndi mbewa. Adagawika m'magulu awiri. Woyamba adapatsidwa mankhwalawo, ndipo wachiwiri amakhala ndi moyo wabwinobwino. Patatha chaka ndi theka, zidapezeka kuti gululi, mogwirizana ndi momwe mankhwalawo sanagwiritsidwire ntchito, adayamba kuwonetsa zizindikiro za kukalamba, ndiko kuti, khalani, khungu, ndikuchepa thupi. Gulu lachiwiri la mbewa zomwe zimagwiritsa ntchito mankhwala othandizira Altai okalamba linali lambiri komanso lathanzi. Ndizofunikanso kudziwa kuti pambuyo pakupanga bwino, opanga mankhwalawa adayamba kudzipeza okha.

Limagwirira ntchito a Metformin

Mphamvu zakuchiritsa za Metformin zimawonetsedwa pakuchepetsa kwa matenda ndi kuwonda. Chotsatira chofunikira ndikuchepetsa kwa mayamwidwe a glucose m'matumbo pomwe akuwonjezera kutulutsa kwake. Mphamvu ya Metformin pa kapamba ndikuti imayambitsa kutulutsa insulin.

Ubwino ndi mawonekedwe a Metformin

Ubwino wa Metformin watsimikiziridwa pofotokoza kusintha kwa matenda a shuga a 2. Zizindikiro zogwiritsidwa ntchito ndizokhazikitsidwa ndi matendawa.

1. Kwa odwala akuluakulu mawonekedwe awo oyera kapena limodzi ndi njira zina.
2. Kwa ana a zaka 10 kapena insulin.

Metformin yokhudza matenda ashuga

The antiglycemic katundu wa mankhwala bwino. Imayitanitsa:

1. Kuchepetsa chakudya.
2. Kupititsa patsogolo kwa kusintha kwa monosaccharides kuti akonze.
3. Kusuntha kwamphamvu kwa glucose kudzera minofu.
4. Mitengo yotsika kwambiri ya triglyceride.

Kuunika kwa chithandizo ndi Metformin kunachitika ndi asayansi ambiri ndipo kuwululira mphamvu yayitali.

Awa ndi mankhwala amkamwa a hypoglycemic ochokera ku banja la Biguanide. Amadziwika kuti woyamba kukhala woyamba antidiabetesic monotherapy pochizira odwala omwe adapezeka ndi matenda a 2. Katundu wa mankhwala amalola kuti ligwiritsidwe ntchito poyimitsa zizindikiro mwa odwala omwe ali ndi zaka zambiri. Odwala ena, kulephera kugwiritsa ntchito kuti akwaniritse kuyendetsa glycemic kosatha kumapangitsa kulumikizidwa kwa othandizira ena odwala.

Cholinga chachikulu chovomerezeka ndi kukhazikika kwa glucose wamagazi ndikuchepetsa kwa kuchuluka kwa zovuta. Ubwino ndi kuvulaza kwa Metformin mu prediabetes ndi madokotala akhala akuphunzira kwambiri kwazaka zambiri. Zomwe zimatha kupanga zimatha kupewa matenda.

Kutenthetsa kwa Metformin

Ntchito yofunikira ndikuthandizira njira yochepetsera kunenepa. Malinga ndi kafukufuku wina, chinthu chogwira ntchito chimachepetsa njala, chomwe chimathandiza kwambiri pochepetsa mawonedwe.Mankhwalawa sangolembedwera kuchepa thupi kokha, koma katundu wake amalola kukhudzidwa kwathunthu ndi matendawo. Phindu lalikulu lidzakhala kuphatikiza kwa Metformin ndi zakudya zama carb ochepa komanso kuchita masewera olimbitsa thupi mwamphamvu.

Metformin imalembedwa kwa anthu athanzi omwe ali ndi mapaundi owonjezera. Pankhaniyi, muyenera kupimidwa pafupipafupi, kuunika kuchuluka kwa magazi, makamaka kuchuluka kwa shuga, cholesterol ndi michere ya chiwindi.

Zambiri polandila ndi Mlingo wa Metformin

Mankhwalawa amalembedwa ndi adokotala mosamalitsa kuti apewe kuvulala. Malangizo apadera akukhudzana ndi kuchuluka kwa kuchuluka kwa mlingo. Izi zimachepetsa chiopsezo ndikuwonjezera phindu.

• piritsi limodzi la 500 mg pakudya kadzutsa kamodzi kapena sabata limodzi,
• mlingo womwewo 2 pa tsiku 1 sabata,
• sabata yakuvomerezedwa katatu patsiku.

Ngati kulephera kwakanthawi kwa muyezo wapezeka ndi dokotala, dokotalayo angaganize kuti musinthe ndikusintha katundu pang'onopang'ono.

Anthu okalamba sayenera kumwa zoposa 1 g patsiku, kuti apewe kuvulaza.

Ndi bwino kumwa mankhwalawo ndi chakudya, chifukwa zimawonjezera kuyamwa kwake m'mimba ndikuchepetsa mavuto - m'mimba kukokana, nseru. Mukamamwa Metformin kumayambiriro kwa chithandizo chamankhwala komanso musanadye, matenda am'mimba amatha.

Kugwiritsa ntchito Metformin pamimba yopanda kanthu sikofunikira chifukwa chakuchepa kwa ntchito ndi vuto chifukwa chakukwiya kwambiri kwa m'mimba. Usiku, Metformin sidzapindulanso ngati dokotalayo sanapange mwayi wa chiwembu chotere. Pofuna kuti musayiwale kumwa mankhwalawa, muyenera kuyeserera kumwa monga momwe munapangidwira - nthawi yomweyo. Mfundo yofunikira ndikukhazikitsa alarm kuti azikumbutsa.

Metformin Yovuta ndi zoyipa

Mankhwala amatha kubweretsanso mavuto ena. Vuto limakhalapo munthu akangoyamba kumwa mankhwalawa, koma nthawi zambiri pakatha milungu ingapo kusamvana kumatha. Zovuta zilizonse ziyenera kudziwitsidwa kwa asing'anga kuti atsimikizire phindu lokha kutsatira.

Zotsatira zoyipa kwambiri:

• kutentha kwa mtima
• kupweteka m'mimba
• kusanza kapena kusanza
• kapangidwe ka mpweya
• kutsegula m'mimba
• kudzimbidwa
• chifuwa
• migraine
• kulawa kwazitsulo mkamwa.

Katundu woyipa akhoza kukhala woopsa kwambiri. Amatha kuvulaza kwambiri anthu omwe ali ndi matenda a impso komanso chiwindi. Chimodzi mwazinthu izi ndi lactic acidosis - kudzikundikira kwa lactic acid mu minofu. Kuvulaza kumawoneka pachiwopsezo cha atrophy ya minofu.

Mwa odwala ena, kuperewera kwa vitamini B12 kumachitika, zomwe zimapangitsa kuvulaza kwamanjenje. Izi zimatha kudzetsa matenda a stroke, kuchepa magazi, komanso kukhumudwa.

Nthawi zina, kuvulaza mwa mtundu wa hypoglycemia kumachitika ngati mankhwala aphatikizidwa:

• ndi zakudya zopanda thanzi,
• zolimbitsa thupi,
• kuvutitsidwa kwa ethanol,
• mankhwala ena am'magazi omwe ali ndi matenda osakhazikika.

Contraindication potenga Metformin

Mankhwalawa amatha kuvulaza thupi. Zoyipa zotsutsana ndi izi:

• pali matenda a chiwindi ndi impso,
• wapezeka ndi vuto la mtima komanso matenda oopsa,
• kumwa mowa pafupipafupi.
• kusowa kwamadzi
• ntchito pamaso maphunziro a x-ray, tomography, ntchito,
• mavuto pambuyo sitiroko,
• mimba ndi mkaka wa m`mawere
• zaka mpaka 10 ndi zaka zoposa 70.

Kugwirizana kwa Metformin ndi mankhwala ena

Mankhwala ena amasokoneza ntchito yogwira ntchito ya Metformin ndipo imatha kuvulaza wodwalayo limodzi ndi iye.

Ngati mukugwiritsa ntchito zilizonse zotsatirazi, mungafunike kuwunika kuchuluka kwa shuga komanso kusintha momwe mulili:

• mapiritsi a steroid, mwachitsanzo, prednisone,
• okodzetsa monga furosemide,
• mankhwala ochizira matenda amtima komanso kuthamanga kwa magazi,
• maimuna achimuna ndi achikazi monga testosterone, estrogen ndi progesterone,
• anticoagulants
• mankhwala ena a shuga.

Amayi ena adzafunikira kusintha pang'ono kwa Metformin atangoyamba mapiritsi oletsa kubereka. Mankhwala a Hormonal ali ndi mphamvu yowonjezera shuga.

Ma Analogs a Metformin

Ma Analogs a mankhwalawa ndi omwe ali ndi chinthu chofanana - ichi ndi Siofor, Bagomet, Glucophage, Formmetin, Glformin. Zawo ndi zofanana kwambiri. Osasankha mapiritsi pamalangizo a dokotala, ndi adokotala okha omwe angapereke malingaliro. Phindu lomwe mungayembekezere lodzilowetsa ndekha silingakhale.

Metformin imayambitsa kuchepa thupi

Metformin imabweretsa kuwonda, koma osati nthawi yomweyo komanso kuphatikiza zakudya. Kuchita zolimbitsa thupi moyenera kwa anthu kumafunikiranso. Njira yothetsera vutoli siyofunika kumwa kokha chifukwa cha kunenepa. Pali chiwopsezo cha zotsatira zoyipa, ndipo kuphatikiza ndi mankhwala ena sikuthandiza nthawi zonse. Kuphatikiza apo, mankhwalawa samapereka chokhazikika, chifukwa anthu nthawi zambiri amapeza ma kilogalamu otayika. Zomwe zimagwiritsidwa ntchito pazinthuzi zilibe mawonekedwe osatsutsika poligwiritsa ntchito pakuchepetsa thupi. Monga lamulo, phindu lopindulitsa limakhalapo kwakanthawi.

Ndani angatenge metformin

Mankhwala akuwonetsedwa kwa akulu. Itha kugwiritsidwa ntchito kufulumizitsa njira yochepetsera kunenepa. Kwa anthu otere, njira yofunikira kwambiri ndikuphatikiza ndi zakudya zoganiza bwino.

Ana ochokera zaka 10 amamwa pokhapokha ngati dokotala akuwalangizani. Metformin sinafotokozedwenso kwa ana aang'ono kuti asawononge thupi.

Kodi ndingatenge pathupi ndikunyambita

Gwiritsani ntchito panthawi yovomerezeka. Kafukufuku sawonetsa zoopsa.

Osavomerezeka pa mkaka wa m'mawere chifukwa chakutha kulowa mkaka wa m'mawere. Zitha kuvulaza mwana, popeza amaloledwa kugwiritsa ntchito kuyambira wazaka 10 zokha.

Kumwa Metformin pa nthawi ya pakati ndikofunikira pokhapokha kuyang'aniridwa ndi dokotala, pomwe kudyetsa kumabweretsa mavuto.

Kodi Metformin Imakulitsa Moyo

Ofufuza aku Belgian ochokera ku Yunivesite ya Leuven adapereka umboni woyesa kuti Metformin imalepheretsa kukalamba ndipo imakhudza kukula kwa nthawi yomwe munthu amakhala ndi moyo. Pogwira ntchito ndi ma laboratori a labot, adawonetsa kuti katundu wake amawonjezera kuchuluka kwa mitundu ya mpweya yomwe imagwira m'maselo. Izi zimakhudza kugwira ntchito kwa tizilombo.

Kafukufuku wina wapeza kuti kukula kwa chotupa ndi kuchepa kwa mitsempha kumachepetsa. Koma lero ndikungoyesa kwa sayansi, kugwiritsa ntchito pa anthu kudzafunika mayeso owonjezera. Pakadali pano, zotsatira zofunikira zowonjezera nthawi ya moyo sizinatsimikizidwe.

Zomwe zili bwino: Metformin, Glucofage kapena Siofor

Mankhwala oyamba ndi Metformin. Kusiyana pakati pa zopangidwazo kumafotokozedwa ndi zomwe zimapezeka pazinthu zoyambira ndi zowonjezera mu mawonekedwe a wowuma kapena macrogol. Kuphatikiza apo, Siofor yopanga insulin yokwanira sagwiritsidwa ntchito, ndipo glucophage imaloledwa. Pali zovuta pamachitidwe olandirira. Ndizosatheka kunena mosakayikira kuti ndiyani wodwala - izi ziyenera kukhazikitsidwa atayesedwa. Kusankha pawokha sikubweretsa zotsatira zofunikira.

Kodi Metformin Imateteza Ku Khansa

Amayi omwe amagwiritsa ntchito Metformin pa matenda ashuga kwa zaka zopitilira zisanu anali ndi chiopsezo chocheperako cha kupitilira kwa khansa ya m'mawere. Kupindulitsa kwabwino kwa mankhwalawo, komabe, kunali kochokera pamitu yochepa. Odwala 17 okha ndi omwe adagwiritsa ntchito Metformin kwa nthawi yayitali ndipo adapezeka kuti ali ndi khansa ya m'mawere. Kuphatikiza apo, mapangidwe a kafukufukuyu samaphatikizira lingaliro lililonse pankhani ya kupuma, atero asayansi otsogozedwa ndi Dr. Christoph R. Meyer kuchokera ku University Hospital Basel ku Switzerland. Adafalitsa zotsatira za mayeso pa Marichi 18, 2010.

Kafukufuku wambiri akuwonetsa chiopsezo chochepetsetsa cha khansa komanso kuchepa kwaimfa pakati pa anthu omwe ali ndi matenda a shuga 2 a Metformin. Poyesedwa pa makoswe, zinatsimikiziridwa kuti zimasokoneza kukula kwa maselo a khansa.

Zotsatira za kafukufuku wazomwe zimachitika chifukwa cha mankhwalawa ku khansa zikuwonetsa kuti pali phindu chifukwa chogwiritsa ntchito.

Pomaliza

Phindu ndi zovuta za Metformin zimatha kungoyesedwa payekhapayekha, kutengera njira ya matendawa komanso kuyang'aniridwa ndi dokotala. Metformin amachepetsa shuga m'magazi ndikumachepetsa matenda ashuga a 2. Ndi mtundu 1, khansa komanso kuchepa thupi, pamakhala zotsatira zabwino kuchokera ku mayeso azachipatala. Palinso chidziwitso chazinthu zabwino za Metformin za ovary ya polycystic, koma pokhapokha ngati kuphwanya glucose kumachitika. Mapiritsi omwe amadzipaka okha sakanenedwa kuti apewe kuvulazidwa.

Pharmacological zimatha mankhwala

Metformin ndi mankhwala ochokera ku kalasi ya biguanides, yomwe imagwiritsidwa ntchito mwachangu pochiza matenda amtundu wa 2 shuga.

Chofunikira chachikulu cha mankhwalawo ndi Metroformin hydrochloride, silicon dioxide, povidone, magnesium stearate, macrogol amagwiritsidwa ntchito ngati zida zothandiza.

• kulowerera kwa hyperinsulinomia,
• zimapangitsa kuchepetsa thupi,
• amachepetsa chiopsezo cha matenda opatsirana ndi mtima,
• zimakhudza kagayidwe kazida ka lipid m'thupi,
• amachepetsa makutidwe ndi mafutawa,
• Amachepetsa kuchuluka kwa cholesterol yoyipa,
• amachepetsa chiopsezo cha matenda a shuga,
• amachepetsa triglycerides.

Mukamalandira mankhwalawa pakapita masiku angapo, mutha kuwona kupezeka kwake kosalekeza m'magazi ochepa.

Malangizo ogwiritsira ntchito mankhwalawa

Mankhwala Metformin amapezeka mu mawonekedwe apiritsi osiyanasiyana. Mankhwalawa atha kugulidwa ku malo azamankhwala azigawo mwanjira zotsatirazi:

• 500 mg yogwiritsa ntchito piritsi limodzi,
• 850 mg yogwira pophika
• 1000 mg ya metformin.

Mlingo wocheperapo womwe mankhwalawa amayamba ndi 500 mg ya mankhwalawa ndikuwonjezereka kwina. Komanso, muyezo umodzi womwewo sungathe kupitirira chiwerengero chomwe chatchulidwa pamwambapa. Kuti mulekerererane bwino mankhwalawo, komanso ngati pali Mlingo wokhazikika, kuchuluka kwake kungagawike pawiri kapena katatu masana. Chifukwa chake, zitha kuteteza kukula kwa zoyipa. Mulingo woyenera wa mankhwalawa sayenera kupitirira 3000 mg yogwira ntchito.

Nthawi zina, mwachitsanzo, kumwa mankhwalawa chifukwa cha prophylactic, mlingo umayenera kuchepetsedwa kawiri kapena katatu.

Kuchuluka kwa kumwa mankhwalawa kumatheka patatha milungu iwiri ya chithandizo.

Ngati, pazochitika zina, mankhwala adasowa, palibe chifukwa chowalipirira pochulukitsa mlingo wotsatira.

Mukamamwa mankhwalawa, ndikofunikira kuganizira njira yachilengedwe ya kagayidwe kachakudya ndi thanzi labwino.

Tiyenera kudziwa kuti pali chiopsezo chachikulu cha lactic acidosis.

Zotsatira zoyipa za kumwa mankhwalawa

Chithandizo ndi chithandizo ndi Metformin ziyenera kuchitika moyang'aniridwa ndi achipatala. Ndizosavomerezeka kumwa mankhwalawa mu Mlingo wopitilira malangizo a dokotala, kapena molumikizana ndi mankhwala ena osankhidwa ndi wodwalayo.

Kugwiritsa ntchito molakwika kwa Metformin kumatha kuyambitsa zovuta zambiri, zovuta zamavuto a thupi la munthu atseguka.

Zowonetsa zazikulu za mankhwalawa zimaphatikizapo izi:

Ndipo ngakhale Metformin ikuphatikizidwa ndi gulu la mankhwala otetezeka, muyenera kuwerenga mosamala mawunikidwe onse oyipa. Mankhwala oterowo amatha kukhala owopsa ngati simutsatira malamulo oyenera kutsata.

Lactic acidosis ndi imodzi mwazotsatira zoyipa zomwe zimachitika chifukwa cha mankhwala osokoneza bongo ambiri.

Kodi mankhwalawo amaletsedwa nthawi ziti?

Mankhwala Metformin ali ndi mndandanda wofunikira wa zotsutsana ndikugwiritsa ntchito kwake.

Chifukwa chake, musanayambe maphunziro, muyenera kuwerenga malangizo mosamala. Zotsatira zoyipa zilizonse zikachitika, muyenera kufunsa dokotala ndi kukambirana zina za mankhwalawa.

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pamaso pa zinthu ndi matenda:

Atsikana ndi amayi oyembekezera panthawi yoyembekezera amaletsedwa kutenga Metformin, chifukwa mavuto osiyanasiyana ndi kukhazikika kwa mwana wosabadwayo angachitike. Ndi chifuno chofunikira chamankhwala, mayi ayenera kusiya kuyamwitsa.

Kuphatikiza apo, ana osakwana zaka khumi ndi zisanu ali pachiwopsezo.

Mndandanda wa mankhwala Metformin

Ndemanga za odwala zimawonetsa zabwino zomwe chithandizo cha Metformin chimabweretsa. Mtengo wake wapakati m'gawo la Russian Federation ukhoza kuchoka pa ma 170 mpaka 260 rubles.

1. Glucophage - mapiritsi ochepetsera shuga omwe amapezeka mosiyanasiyana. Chofunikira chachikulu ndi metformin hydrochloride. Zimathandizira kukula kwamwazi wamagazi popanda kuchititsa hypoglycemia. Gawo lamitengo yamapiritsi oterowo, monga lamulo, sapitilira ma ruble 200.
2. Bagomet - mankhwala, momwe muli zinthu ziwiri zogwira ntchito nthawi imodzi - metformin ndi glibenclamide. Ichi ndi mankhwala osakanikirana omwe amaphatikiza mphamvu za Biguanides ndi sulfonylureas. Nthawi zambiri amagwiritsidwa ntchito pochiza matenda amisala a shuga a 2 omwe sanali insulin. Mtengo wapakati wa mankhwalawo ndi ma ruble 210-240.
3. Siofor ndi mankhwala ochokera pagulu la Biguanide, womwe ndi chithunzi chonse cha mapiritsi a Metformin. Mtengo wake wapakati pamasitolo azitawuni amatha kukhala 250 mpaka 350 rubles.
4. Sofamet - mapiritsi ochokera ku gulu la dimethylbiguanides, omwe amapezeka osiyanasiyana. Kutengera kuchuluka kwa zinthu zomwe zimagwira, mtengo wa mankhwalawo umakhazikitsidwa. Monga lamulo, mtengo wa Sofamed m'magawo osiyanasiyana amzindawu sapitilira ma ruble 130,
5. Nova Met.

Zambiri pa Metformin zimaperekedwa mu kanema munkhaniyi.

Kodi mankhwalawa adzagulitsidwa liti?

Nkhani yolenga njira yothetsera kukalamba yafalikira padziko lonse lapansi. Ambiri amavomereza kudzipereka ndikuyesera chaka chino. Mwina aliyense amene wamva nkhani yokhudza kupanga mankhwala ochepetsa ukalamba amakhala ndi chidwi ndi nthawi yomwe adzagulitsidwe pagulu.

Monga tanena kale, mu Novembala chaka chino gawo lachitatu loyesera mankhwala liyamba, lomwe limachepetsa ukalamba. Pakhala maphunziro pa anthu omwe asankha kudzipereka. Asayansi a Altai samapereka tsiku lenileni la kulandira mankhwalawo pagulu la anthu. Komabe, akutsimikizira kuti izi zidzachitika zaka ziwiri.

"Metformin" - machiritso okalamba

Masiku ano, aliyense amafuna kukhala ndi moyo wautali komanso kuti azioneka aang'ono nthawi yomweyo. Asayansi ochokera padziko lonse lapansi akuyesera kupanga njira yochizira matenda okalamba. Metformin, yomwe amadziwika kuti ndi mankhwala a shuga, amawathandiza kuchita izi. Asayansi ochokera ku United States of America aganiza kuti ukalamba ndi matenda omwe ayenera kuthandizidwa. Chaka chatha, adapeza kuti Metformin imachepetsa kuwonongeka kwa thupi. Pamaziko ake, asayansi akukonzekera kupanga njira yothandizira kukalamba.

Metformin inayesedwa pa nyongolotsi. Ngakhale anali ndi zaka zambiri, khungu lawo silinkakhala losalala ndipo moyo wawo umakula kwambiri.

Mankhwala a altai cirrhosis

Mankhwala olimbana ndi ukalamba, omwe adapangidwa ndi asayansi a Altai, ali ndi mikhalidwe ina yabwino. Monga tanena kale, pa gawo loyamba loyesedwa adayesedwa pa makoswe. Asayansi a Altai atsimikizira kuti mankhwalawa amathandizira kuti asachedwetse kukalamba, komanso amachiritsa matenda a chiwindi. M'makola omwe adapatsidwa mankhwalawo, maselo a chinthu chofunikira kwambiri adabwezeretseka. Kutha kuchiritsa chiwindi ndikofunikira kwambiri pakapezeke chiphaso ku Unduna wa Zaumoyo.

Kuchepetsa Ntchito

Kodi ndizotheka kumwa Metformin kuti muchepetse thupi, ngati shuga ndichabwinobwino? Kuwongolera uku kwa mankhwalawo kumachitika chifukwa chakutha kwawo kukamenya nkhondo osati ndimipangiri yamitsempha yamagazi, komanso ma deposits amafuta.

Kuchepetsa thupi mukamamwa mankhwala kumachitika chifukwa chotsatira:

• kuthamanga kwamafuta oxidation,
• kutsika kwa kuchuluka kwake,
• kuchuluka kwa glucose chifukwa cha minofu.

Izi zimachotsanso kumverera kwanjala yosalekeza, zimathandizira kuti thupi lizikula msanga. Koma muyenera kutentha mafuta mukudya.

Kuti muchepetse kunenepa, muyenera kusiya:

Masewera olimbitsa thupi, monga masewera olimbitsa thupi olimbitsa thupi tsiku lililonse, amafunikanso. Ma regimen akumwa ayenera kuyang'aniridwa mosamala. Koma kumwa mowa ndikoletsedwa.

Tiyenera kukumbukira kuti kuchepa thupi kumangowonjezera mphamvu ya mankhwalawo. Ndipo adokotala okha ndi omwe angadziwe kufunika kwa Metformin kuti athane ndi kunenepa kwambiri.

Ntchito yoletsa kukalamba (anti-okalamba)

Metformin imagwiritsidwanso ntchito polepheretsa kusintha kokhudzana ndi zaka m'thupi.

Ngakhale mankhwalawa siwopanda chiyembekezo chaubwana wamuyaya, amakulolani:

• bwezeretsani kuchuluka kwa bongo ku mawu ofunikira,
• kuchepetsa chiopsezo cha neoplasms yoyipa,
• limbitsani mtima minofu.

Vuto lalikulu la chiwalo cholimba cha kukalamba ndi atherosulinosis, yomwe imasokoneza kugwira ntchito kwa mtima ndi mitsempha yamagazi. Ndiye amene amayambitsa imfa zambiri zomwe zimachitika asanakwane.

Zotsatira za cholesterol yomwe imatsogolera ku atherosulinosis imachitika chifukwa:

• kuphwanya kachitidwe koyenera ka kapamba,
• kulakwitsa kwa chitetezo chamthupi,
• mavuto a metabolic.

Cholinga chake ndikukhalanso ndi moyo womwe anthu okalamba amatsogolera, pomwe amakhala ndi chakudya chambiri komanso zopatsa mphamvu, ndipo nthawi zina zimawonjezera.

Izi zimabweretsa kukokomeza magazi m'mitsempha ndikupanga ma cholesterol amana. Mankhwalawa amathandizira kuchepetsa mafuta m'thupi, kusintha kayendedwe ka magazi ndi kusintha ntchito ya ziwalo zonse ndi machitidwe. Ndiye kodi Metformin ingatengedwe ngati palibe shuga? Ndizotheka, koma pokhapokha ngati pali contraindication.

Zoyipa pa Metformin ndi:

• acidosis (pachimake kapena chovuta),
• nthawi ya pakati, kudyetsa,
• Matendawa ndimankhwala
• chiwindi kapena vuto la mtima,
• myocardial infaration
• Zizindikiro za hypoxia mukamwa mankhwalawa.
• kuchepa kwa thupi ndi matenda opatsirana,
• matenda am'mimba thirakiti (zilonda),
• kuchita zolimbitsa thupi kwambiri.

Lemberani Metformin kuti muchepetse thupi komanso kuti musinthe thupi ndikufunika kukumbukira zotsatirapo zoyipa:

• chiopsezo chowonjezereka cha anorexia
• mseru, kusanza, kutsegula m'mimba kumachitika,
• nthawi zina kukoma kwazitsulo kumawonekera
• kuchepa magazi kumatha kuchitika
• pali kuchepa kwa mavitamini a B, komanso kukonzekera kowonjezera komwe kuli
• kugwiritsa ntchito kwambiri, hypoglycemia ingachitike,
• Kuchita zosagwirizana kumabweretsa mavuto amtundu wakhungu.

Makanema okhudzana nawo

Makhalidwe a pharmacological ndi malangizo ogwiritsira ntchito mankhwala Metformin:

Njira yogwiritsira ntchito Metformin osati pochiza matenda ashuga siyachilendo. Yambani kudzisankhira nokha ndikusankha mlingo woyenera nokha osakakumana ndi opereka chithandizo chamankhwala kuti akhale ndi zotsatila zoopsa zomwe sizingachitike. Ndipo ngakhale atayang'anitsitsa wodwala akamva, kutenga nawo gawo kwa dokotala pakuchepetsa / kuyambiranso ndi Metformin ndikofunikira.

Fomu ya Mlingo: & nbsp mapiritsi okhala ndi mafilimu

Piritsi limodzi lophimbidwa ndi 1, 500 mg ili ndi:

Kamangidwe ka piritsi yofunika:

Chithandizo: metformin hydrochloride - 500.0 mg.

Othandizira : povidone (kolidone 90 F) - 18,0 mg, hypertose yotsika-30.0 mg, glyceryl dibehenate - 49.0 mg, magnesium stearate - 3.0 mg.

Mapangidwe a chipolopolo cha piritsi: hypromellose - 7.41 mg, titanium dioxide - 5.70 mg, polydextrose - 2.85 mg, talc - 1.90 mg, macrogol 3350 - 1.14 mg.

Piritsi limodzi lophimbidwa 1, 850 mg ili ndi:

Kamangidwe ka piritsi yofunika:

Chithandizo: metformin hydrochloride - 850.0 mg.

Othandizira : povidone (kolidone 90 F) - 30,6 mg, hypertose yotsika-m'mapapo - 51.0 mg, glyceryl dibehenate - 83.3 mg, magnesium stearate - 5.1 mg.

Kuphatikizidwa kwa chipolopolo cha piritsi: hypromellose - 12.48 mg, titanium dioxide - 9.60 mg, polydextrose - 4.80 mg, talc - 3.20 mg, macrogol 3350 - 1.92 mg.

Piritsi limodzi lophimbidwa 1, 1000 mg ili ndi:

Kamangidwe ka piritsi yofunika:

Chithandizo: metformin hydrochloride - 1000.0 mg.

Othandizira : povidone (kolidone 90 F) - 36.0 mg, Hypertose wotsika - 60.0 mg, glyceryl dibehenate - 98.0 mg, magnesium stearate - 6.0 mg.

Kuphatikizidwa kwa chipolopolo cha piritsi: hypromellose - 14.82 mg, titanium dioxide 11.40 mg, polydextrose - 5.70 mg, talc - 3.80 mg, macrogol 3350 - 2.28 mg.

: Kufotokozera: Mapiritsi okhala ndi mawonekedwe ozungulira, biconvex, wokutidwa ndi utoto wazithunzi za zoyera kapena pafupifupi zoyera, wokhala pachiwopsezo mbali imodzi ndi chizindikiro chosemedwa " f "kwa wina. Gulu la Pharmacotherapeutic: Hypoglycemic wothandizira wa gulu lalikuluuanide pakukonzekera kwa pakamwa kwa ATX: & nbsp

Metformin imachepetsa hyperglycemia popanda kutsogola kukula kwa hypoglycemia. Mosiyana ndi zotumphukira za sulfonylurea, sizimalimbikitsa kutulutsa insulin ndipo sizikhala ndi vuto loti munthu azikhala wathanzi. Zimawonjezera chidwi cha zotumphukira zolandilira ku insulin ndikugwiritsa ntchito shuga ndi maselo. Imachepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis.

Kuchepetsa mayamwidwe m'matumbo.

Metformin imathandizira kapangidwe ka glycogen pochita glycogen synthase. Kuchulukitsa kuthekera kwamitundu yonse yamtundu wama glucose oyenda.

Kuphatikiza apo, imakhala ndi phindu pa metabolidi ya lipid: imachepetsa zomwe zimakhala ndi cholesterol yonse, lipoproteins yotsika komanso triglycerides.

Ngakhale mutatenga Metformin, thupi la wodwalayo limakhalabe lolimba kapena limatsika pang'ono.

Kafukufuku wachipatala adawonekeranso kugwira ntchito kwa metformin popewa matenda ashuga odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezereka pakukula kwa mtundu wachiwiri wa matenda ashuga, momwe kusintha kwasinthidwe kwa moyo sikunalole chiwonetsero chokwanira cha glycemic.

Madzi ndi kugawa

Pambuyo pakukonzekera pakamwa, imayamwa kwathunthu kuchokera m'mimba. Mtheradi bioavailability ndi 50-60%. Kuchuluka kwa ndende (Cmax) (pafupifupi 2 μg / ml kapena 15 μmol) m'madzi a plasma kumachitika pambuyo pa maola 2.5. Ndi kukakamiza komweko pakudya, kuyamwa kwa metformin kumachepetsedwa ndikuchedwa. yogawidwa mwachangu mu minofu, sikuti imagwirizana ndi mapuloteni a plasma.

Kutetemera ndi chimbudzi

Amapangidwira pamlingo wofooka kwambiri ndikuwonetsa impso. Kuwonekera kwa metformin m'maphunziro abwino ndi 400 ml / mphindi (kuchulukitsa kanayi kuposa momwe chivomerezo cha creatinine chimakhalira), chomwe chimawonetsa kukhalapo kwa katulutsidwe ka tubular. Hafu ya moyo ndi pafupifupi maola 6.5. Ndi kulephera kwa aimpso, zimachulukana, pamakhala chiopsezo cha kukopeka kwa mankhwalawa.

Type 2 shuga mellitus, makamaka kwa odwala omwe ali ndi kunenepa kwambiri, komanso kulephera kwamankhwala othandizira kudya komanso zochitika zolimbitsa thupi:

- akuluakulu, monga monotherapy kapena kuphatikiza ena othandizira pakamwa kapena ena ndi insulin,

- mwa ana kuyambira zaka 10 monga monotherapy kapena osakanikirana ndi insulin.

Kupewera kwa matenda ashuga amtundu 2 kwa odwala omwe ali ndi prediabetes omwe ali ndi chiopsezo chowonjezera cha matenda amtundu wa 2, momwe kusintha kwasinthidwe sikunalole kuti chiwonetsero chokwanira cha glycemic chikwaniritsidwe.

- Hypersensitivity to metformin kapena kwa aliyense wakonda,

- matenda ashuga ketoacidosis, matenda a shuga, chikomokere,

- kulephera kwa aimpso kapena kuwonongeka kwaimpso (kulengedwa kwa creatinine kupitirira 45 ml / min),

- zovuta pachimake ndi chiwopsezo cha matenda aimpso: kuchepa kwa magazi (ndi kutsegula m'mimba, kusanza), matenda opatsirana opatsirana, kugwedezeka,

- mawonetseredwe azachipatala owonetsa matenda opweteka kwambiri kapena osachiritsika omwe angayambitse kukula kwa minofu hypoxia (kuphatikiza kulephera kwa mtima, kuperewera kwa mtima ndi hemodynamics yosakhazikika, kulephera kupuma, kulowetsedwa kwapachimake),

- opaleshoni yayikulu ndikuvulaza pamene chithandizo cha insulin chikusonyezedwa (onani gawo "Malangizo apadera"),

- Kufooka kwa chiwindi, matenda a chiwindi,

- uchidakwa wambiri, chakumwa choledzeretsa chachikulu,

- lactic acidosis (kuphatikiza ndi ma anamnesis),

- gwiritsani ntchito maola osakwana 48 isanachitike komanso mkati mwa maola 48 mutapanga maphunziro a radioisotope kapena X-ray ndikukhazikitsa ma iodine okhala ndi zosiyana pakati (onani gawo "Kuyanjana ndi mankhwala ena"),

- kutsatira chakudya cha hypocaloric (zosakwana 1000 kcal / tsiku).

- mwa anthu opitilira zaka 60 omwe amagwira ntchito zolimbitsa thupi, zomwe zimakhudzana ndi chiwopsezo chotenga lactic acidosis,

- odwala aimpso kulephera (kulengedwa kwa creatinine 45-59 ml / min),

- nthawi yoyamwitsa.

Mimba ndi kuyamwa:

Matenda a shuga omwe sanakulipiridwe panthawi ya kubereka amalumikizidwa ndi chiwopsezo chowonjezeka cha zilema zakubadwa ndi kufa kwa perinatal. Zambiri zomwe zikusonyeza kuti kutenga metformin mwa amayi apakati sikuti kumawonjezera mwayi wokhala ndi vuto la kubala mwa ana.

Pokonzekera kutenga pakati, komanso pathupi pathupi lomwe limayamwa kutenga metformin ndi prediabetes ndi mtundu wa 2 shuga, mankhwalawo ayenera kusiyidwa, ndipo ngati matenda amtundu wa 2 asadwala, mankhwala a insulin ndi omwe adapangidwa. Ndikofunika kusungabe kuchuluka kwa shuga m'magazi am'magazi pamlingo woyandikira kwambiri kuti achepetse vuto la fetus.

Metformin imadutsa mkaka wa m'mawere. Zotsatira zoyipa za akhanda pa nthawi yoyamwitsa pamene mukumwa metformin sizinawoneke. Komabe, chifukwa cha kuchuluka kwa deta, kugwiritsa ntchito mankhwalawa panthawi yoyamwitsa sikulimbikitsidwa. Lingaliro loletsa kuyamwitsa liyenera kuganiziridwanso zabwino za kuyamwitsa ndi chiopsezo cha zotsatira zoyipa mwa khanda.

Mlingo ndi makonzedwe:

Monotherapy ndi kuphatikiza mankhwala osakanikirana ndi othandizira ena am'mlomo a hypoglycemic othandizira a mtundu 2 matenda a shuga:

- Mankhwala oyamba mwachangu ndi 500 mg kapena 850 mg katatu patsiku mutatha kudya kapena pakudya.

- Pakadutsa masiku 10-15, tikulimbikitsidwa kuti musinthe mankhwalawa potengera zotsatira za kuyamwa kwa shuga m'magazi a m'magazi. Kuwonjezeka pang'onopang'ono kwa mankhwalawa kumathandiza kuchepetsa zovuta kuchokera m'matumbo am'mimba.

- Mankhwala okonza mankhwalawa nthawi zambiri amakhala 1500-2000 mg / tsiku. Kuti muchepetse mavuto kuchokera m'matumbo am'mimba, mlingo wa tsiku ndi tsiku uyenera kugawidwa mu Mlingo wa 2-3. Mlingo wapamwamba ndi 3000 mg / tsiku, logawidwa pazidutswa zitatu.

- Odwala omwe atenga Mlingo wa 2000-3000 mg amatha kusamutsidwa kupita ku 1000 mg. Mlingo woyenera kwambiri ndi 3000 mg / tsiku, womwe umagawidwa pazigawo zitatu.

Ngati mukufuna kusintha kuchokera ku kutenga wina wothandizidwa ndi hypoglycemic, muyenera kusiya kumwa mankhwalawa ndikuyamba kumwa mankhwalawo pamwambapa.

Kuphatikiza ndi insulin: kuti mupeze kuwongolera bwino kwa shuga wamagazi ndi insulin mwa odwala omwe ali ndi matenda a shuga 2 amatha kugwiritsidwa ntchito ngati mankhwala osakanikirana. Mlingo woyamba wa mankhwalawa ndi 500 mg kapena 850 mg kawiri pa tsiku, pomwe mlingo wa insulin umasankhidwa potengera kuchuluka kwa shuga m'magazi.

Ana ndi achinyamata: mwa ana a zaka 10, mankhwalawa angagwiritsidwe ntchito onse mu monotherapy komanso kuphatikizidwa ndi insulin. Mulingo woyambira woyamba ndi 500 mg kapena 850 mg 1 nthawi patsiku mutatha kudya kapena. Pambuyo masiku 10-15, mlingo uyenera kusinthidwa potengera kuchuluka kwa shuga m'magazi. Mulingo wambiri watsiku ndi tsiku ndi 2000 mg, wogawidwa pamitundu iwiri.

Monotherapy kwa prediabetes: Mulingo woyenera kumwa ndi 1000-1700 mg tsiku lililonse mukatha kudya kapena mgonero, womwe umagawidwa pakawiri.

Odwala aimpso kulephera: Itha kugwiritsidwa ntchito mwa odwala omwe amalephera kupweteka aimpso (creatinine chilolezo cha 45-59 ml / min) pokhapokha ngati pali zovuta zomwe zingakulitse chiopsezo cha lactic acidosis.

Odwala ndi creatinine chilolezo cha 45-59 ml / mphindi, mlingo woyambirira ndi 500 mg kapena 850 mg kamodzi patsiku. Mlingo wapamwamba ndi 1000 mg patsiku, womwe umagawidwa pawiri.

Ntchito ya impso iyenera kuyang'aniridwa bwino (miyezi 3-6 iliyonse).

Ngati chilengedwe cha creatinine chili pansi pa 45 ml / min, mankhwalawa amayenera kuyimitsidwa nthawi yomweyo.

Odwala okalamba: chifukwa kuchepa kwa aimpso ntchito, mlingo wa metformin uyenera kusankhidwa poyang'anitsitsa mawonetseredwe aimpso (kudziwa kuchuluka kwa creatinine m'magazi a seramu osachepera 2-4 pachaka).

Kutalika kwa chithandizo: mankhwalawa ayenera kumwedwa tsiku lililonse, osasokoneza. Ngati chithandizo chalekeka, wodwalayo ayenera kudziwitsa dokotala.

Pafupipafupi mavuto a mankhwala amawerengeredwa motere:

nthawi zambiri: ≥ 1/10, nthawi zambiri: ≥ 1/100, kufunikira.

Matenda a Metabolic ndi zakudya: kawirikawiri - lactic acidosis (onani gawo "Malangizo apadera").

Pogwiritsa ntchito metformin kwanthawi yayitali, kuchepa kwa mayamwidwe a vitamini B12 kungawonedwe. Ngati matenda am'madzi a megaloblastic apezeka, mwayi wa etiology wotere uyenera kuganiziridwa.

Kuphwanya kwamanjenje: nthawi zambiri vuto la kukoma.

Matenda am'mimba: Nthawi zambiri - nseru, kusanza, kutsegula m'mimba, kupweteka kwam'mimba komanso kusowa kudya.

Nthawi zambiri zimachitika nthawi yoyamba ya chithandizo ndipo nthawi zambiri zimadutsa zokha. Popewa Zizindikiro, tikulimbikitsidwa kumwa kawiri kapena katatu patsiku panthawi yachakudya kapena mukatha kudya. Kuchepetsa pang'ono kwa mankhwalawa kumathandizira kulolerana kwamatumbo.

Zovuta za pakhungu ndi minofu yolowera: kawirikawiri - zimachitika pakhungu monga erythema, pruritus, zidzolo.

Kuphwanya chiwindi ndi chindapusa: kawirikawiri - kuphwanya chiwonetsero cha chiwindi ndi hepatitis, atatha kufooka kwa metformin, izi zosafunikira zimatha.

Zambiri zosindikizidwa, zotsatsa zam'mbuyo, komanso mayeso owongolera azachipatala mwa ana ochepera zaka 10-16 akuwonetsa kuti zotsatila za ana zimafanana mwachilengedwe komanso zovuta kwa omwe ali ndi odwala akuluakulu.

Mukamagwiritsa ntchito metformin pa mlingo wa 85 ga (nthawi ya 42,5 nthawi yayikulu tsiku lililonse), kukula kwa hypoglycemia sikunachitike. Komabe, pankhaniyi, kukula kwa lactic acidosis kunawonedwa. Zina zofunikira kwambiri za bongo kapena zovuta zomwe zingagwirizane nazo zimatha kubweretsa kukula kwa lactic acidosis (onani gawo "Malangizo apadera").

Chithandizo: ngati zizindikiro za lactic acidosis, chithandizo ndi mankhwala ziyenera kuyimitsidwa nthawi yomweyo, wodwalayo amayenera kugonekedwa kuchipatala mwachangu ndipo atatsimikiza kuchuluka kwa lactate, kufotokozera kuyenera kumveka bwino. Njira yothandiza kwambiri yochotsa lactate ndi metformin kuchokera mthupi ndi hemodialysis. Mankhwala othandizira amachitidwanso.

Iodini wokhala ndi radiopaque wothandizira: motsutsana ndi kaimidwe ka ntchito yaimpso kwa odwala omwe ali ndi matenda ashuga, kafukufuku wama radiology ogwiritsa ntchito ayodini yemwe amakhala ndi radiopaque angayambitse kukula kwa lactic acidosis. Kuchiza ndi mankhwalawa kuyenera kutha kutengera ntchito ya impso maola 48 asanafike kapena panthawi yomwe mayeso a X-ray amagwiritsa ntchito ayodini omwe amakhala ndi ayodini ndipo osayambiranso kumayambiranso maola 48, pokhapokha ngati ntchito ya impso idadziwika ngati yovomerezeka pakuwunika.

Mowa: ndi kuledzera kwa pachimake, chiopsezo chokhala ndi lactic acidosis imawonjezeka, makamaka:

- kuperewera kwa zakudya m'thupi, zakudya zopatsa mphamvu zochepa,

Ngakhale kumwa mankhwala ayenera kupewa kumwa mowa ndi mankhwala okhala.

Kuphatikiza , kufunikira chisamaliro

Danazole: munthawi yomweyo makonzedwe a danazol ali osavomerezeka kuti apewe hyperglycemic zotsatira zomaliza. Ngati mankhwala a danazol akufunika ndipo atasiya kuyimitsa, kusintha kwa metformin kumafunikira motsogozedwa ndimagazi a shuga.

Chlorpromazine: Pamene kumwedwa mu waukulu Mlingo (100 mg patsiku) kumawonjezera kuchuluka kwa shuga m'magazi, kuchepetsa kutulutsidwa kwa insulin. Mankhwalawa antipsychotic ndipo atayimitsa chomaliza, kusintha kwa metformin kumafunika mothandizidwa ndi glucose.

Glucocorticosteroids (GCS) zokhudza zonse ndi kwanuko zimachepetsa kulolera kwa glucose, kuonjezera kuchuluka kwa shuga m'magazi, nthawi zina zimapangitsa ketosis. Mankhwalawa corticosteroids ndipo atayimitsa kudya kwa chakumapeto, kusintha kwa metformin kumafunika motsogozedwa ndi shuga.

Zotsatira: kugwiritsa ntchito munthawi yomweyo "kudzikongoletsa" okodzetsa kungayambitse kukulitsa kwa lactic acidosis chifukwa chakugwira ntchito kwaimpso. Mankhwala sayenera kutumizidwa ngati creatinine chilolezo chotsika kuposa 60 ml / min.

Katemera wa beta2-adrenergic agonists: onjezani kuchuluka kwa shuga m'magazi chifukwa cholimbikitsidwa ndi beta2-adfuloreceptors. Poterepa, ndikofunikira kuwongolera kuchuluka kwa shuga m'magazi. Ngati ndi kotheka, insulin ikulimbikitsidwa.

Ndi kugwiritsa ntchito pamodzi mankhwala apamwambapa, kuwunikira pafupipafupi kuchuluka kwa shuga wamagazi kungafunike, makamaka kumayambiriro kwa chithandizo. Ngati ndi kotheka, mlingo wa metformin ungasinthidwe munthawi yamankhwala ndikatha.

Mankhwala a antihypertensive , kupatula angiotensin otembenuza enzyme zoletsa amachepetsa magazi. Ngati ndi kotheka, mlingo wa metformin uyenera kusinthidwa.

Ndi munthawi yomweyo kugwiritsa ntchito metformin ndi zotumphukira za sulfonylurea, insulin, acarbose, salicylates hypoglycemia ndizotheka.

Nifedipine kumawonjezera mayamwidwe ndi C m ah wa metformin.

Mankhwala a Cationic (amiloride, quinine, triamteren, trimethoprim ndi) obisidwa mu aimpso tubules kupikisana ndi metformin kwa machitidwe oyendetsa ma tubular ndipo atha kubweretsa kuwonjezeka kwa C max yake.

Lactic acidosis ndichosowa koma chachikulu (kufa kwakukulu pakalibe chithandizo chamankhwala mwadzidzidzi) chomwe chitha kuchitika chifukwa cha kuchuluka kwa metformin. Milandu ya lactic acidosis mutatenga metformin imapezeka makamaka mwa odwala omwe ali ndi matenda osokoneza bongo omwe amalephera kwambiri aimpso.

Zina zokhudzana ndi chiwopsezo ziyenera kuganiziridwanso, monga matenda osaphatikizidwa a shuga mellitus, ketosis, kusala kudya kwa nthawi yayitali, uchidakwa, kulephera kwa chiwindi, komanso vuto lililonse lomwe lingakhale ndi hypoxia yayikulu. Izi zitha kuthandiza kuchepetsa zochitika za lactic acidosis.

Muyenera kuganizira za chiopsezo cha lactic acidosis ndi mawonekedwe a zosakhazikika, monga kukokana kwa minofu, limodzi ndi vuto la dyspeptic, kupweteka kwam'mimba komanso asthenia yayikulu. Lactic acidosis imadziwika ndi kufupika kwa acidotic, kupweteka kwam'mimba komanso hypothermia yotsatiridwa ndi chikomokere. Diagnostic labotale magawo ndi kuchepa kwa magazi pH (osakwana 7.25), kuchuluka kwa lactate m'madzi am'madzi opitilira 5 mmol / l, kuchuluka kwa anion ndi chiŵerengero cha lactate / pyruvate. Ngati metabolic acidosis ikukayikira, ndikofunikira kusiya kumwa mankhwalawo ndikuwonana ndi dokotala nthawi yomweyo.

Kugwiritsa ntchito metformin kuyenera kusiyidwa kwa maola 48 kusanachitike opaleshoni yomwe ikukonzedwa ndipo kutha kupitiliridwanso osapitilira maola 48 zitatha, pokhapokha pakuwunikira ntchito ya impso idadziwika kuti ndiyabwino.

Popeza impso imayesedwa, isanayambe chithandizo ndipo nthawi zambiri pambuyo pake, kuvomerezedwa kwa creatinine kuyenera kutsimikiziridwa:

- kamodzi pachaka kwa odwala omwe ali ndi vuto laimpso,

- osachepera 2-4 pachaka odwala okalamba, komanso odwala omwe ali ndi creatinine chilolezo chotsika.

Ngati creatinine chilolezo zosakwana 45 ml / min, kugwiritsa ntchito mankhwala kumapangidwa. Kusamalidwa makamaka kuyenera kuchitika ngati vuto laimpso lingachitike mwa odwala okalamba, pomwe kugwiritsa ntchito mankhwala a antihypertensive, okodzetsa kapena mankhwala osapweteka a antiidal.

Odwala omwe ali ndi vuto la mtima ali ndi chiopsezo chachikulu chokhala ndi hypoxia komanso kulephera kwa impso. Odwala omwe ali ndi vuto la mtima akudwala ayenera kuyang'anira ntchito ya mtima ndi impso akamamwa metformin.

Metformin yolephera pamtima ndi hemodynamics yosakhazikika imatsutsana.

Ana ndi achinyamata

Kuzindikiritsidwa kwa matenda a shuga a 2 kuyenera kutsimikiziridwa musanayambe chithandizo ndi metformin.

M'maphunziro azachipatala omwe amakhala chaka chimodzi, adawonetsedwa kuti samakhudza kukula komanso kutha. Komabe, chifukwa cha kuchepa kwa nthawi yayitali, kuwunikira mosamala za zotsatira za metformin pama paramu amenewa mwa ana, makamaka pa nthawi yakutha, ndikulimbikitsidwa.

Kuwunikira kosamala kwambiri ndikofunikira kwa ana azaka za 10-12.

Njira zina zopewera

- Odwala amalangizidwa kuti azitsatira zakudya zomwe azidya thupi tsiku lonse. Odwala onenepa kwambiri amalangizidwa kuti azitsatira zakudya zama calorie otsika (koma osachepera 1000 kcal / tsiku).

- Odwala ayenera kudziwitsa dokotala za chithandizo chilichonse choperekedwa ndi matenda ena opatsirana.

- Metformin siyimayambitsa hypoglycemia pa nthawi ya monotherapy, koma kusamala kumalangizidwa mukamagwiritsidwa ntchito limodzi ndi insulin kapena othandizira ena a hypoglycemic (mwachitsanzo, sulfonylureas, repaglinide, etc.).

- zaka zosakwana 60,

- index of body (BMI) ≥35 kg / m 2,

- mbiri ya matenda ashuga,

- mbiri ya banja la anthu odwala matenda ashuga oyambira kale,

- kuchuluka ndende ya triglycerides,

- kuchepa kwa ndende ya HDL cholesterol,

Zizindikiro za hypoglycemia ndi kufooka, kupweteka mutu, chizungulire, kutuluka thukuta, malo amaso, kusawona bwino, kapena chidwi.

Kukopa pa kuthekera kuyendetsa ma transp. Wed Ndi ubweya:

Metformin monotherapy siyimayambitsa hypoglycemia, chifukwa chake, sizikhudza kuthekera koyendetsa magalimoto ndi machitidwe.

Komabe, odwala ayenera kuchenjezedwa za chiopsezo cha hypoglycemia mukamagwiritsa ntchito metformin limodzi ndi mankhwala ena a hypoglycemic (zotumphukira za sulfonylurea, insulin, ndi zina).

Mapiritsi okhala ndi mafilimu, 500 mg, 850 mg, 1000 mg.

Mapiritsi 10 kapena 15 pachimake pomwe panali Plywood film ndikutsindikiza aluminiyumu zojambulazo, kapena mapiritsi 30 kapena 60 pa botolo kapena mtsuko, wokhathamira ndi chivindikiro chokhala ndi kapena osatsegula oyamba, opangidwa ndi polyethylene.

Botolo 1 kapena akhoza, kapena 3, 6, 9 kapena 12 matuza a mapiritsi 10, kapena 2, 4, 6 kapena 8 matuza a mapiritsi 15 aliwonse, limodzi ndi malangizo ogwiritsira ntchito kuchipatala, amaikidwa pakatoni kamatoni.

Pamalo amdima pakutentha kosaposa 25 ° C. Pewani kufikira ana.

Kudzipatsa nokha mankhwala kungavulaze thanzi lanu.
Ndikofunikira kufunsa dokotala, komanso kuwerenga malangizo musanayambe kugwiritsa ntchito.

Zizindikiro zogwiritsidwa ntchito

Type II shuga mellitus (osadalira insulini) wopanda mankhwala othandizira, makamaka odwala onenepa kwambiri:

Monga monotherapy kapena kuphatikiza mankhwalawa molumikizana ndi ena othandizira pakamwa a hypoglycemic kapena molumikizana ndi insulin pochizira akuluakulu.

Monga monotherapy kapena kuphatikiza mankhwala omwe ali ndi insulin pochiza ana opitirira zaka 10.

Mlingo ndi makonzedwe

Monotherapy kapena kuphatikiza mankhwalawa molumikizana ndi ena othandizira pakamwa.

Akuluakulu Nthawi zambiri, muyeso woyamba wa 500 mg kapena 850 mg wa metformin katatu patsiku panthawi ya chakudya kapena pambuyo pake. Pambuyo masiku 10-15 chithandizo, mlingo uyenera kusinthidwa malinga ndi zotsatira za miyeso ya seramu glucose. Kuwonjezeka kwapang'onopang'ono kwa mankhwalawa kumathandizira kuchepetsa zoyipa kuchokera kumimba.

Pochiza Mlingo wambiri, Metformin amagwiritsidwa ntchito muyezo wa 1000 mg.

Pankhani ya kusintha kwa mankhwalawa ndi Metformin, ndikofunikira kusiya kumwa mankhwala othandizira ena.

Kuphatikiza mankhwala osakanikirana ndi insulin.

Kuti akwaniritse bwino kuchuluka kwa shuga m'magazi, metformin ndi insulin zitha kugwiritsidwa ntchito ngati mankhwala osakanikirana. Mwachizolowezi, mlingo woyambira ndi 500 mg kapena 850 mg wa metformin katatu patsiku, pamene mlingo wa insulin umasankhidwa malinga ndi zotsatira za kuyeza shuga.

Monotherapy kapena mankhwala ophatikizira limodzi ndi insulin.

Ana. Metformin imalembedwa kwa ana opitirira zaka 10. Nthawi zambiri, muyeso woyambirira ndi 500 mg kapena 850 mg wa metformin 1 nthawi patsiku panthawi kapena mukatha kudya. Pambuyo masiku 10-15 chithandizo, mlingo uyenera kusinthidwa malinga ndi zotsatira za miyeso ya seramu glucose.

Kuwonjezeka kwapang'onopang'ono kwa mankhwalawa kumathandizira kuchepetsa zoyipa kuchokera kumimba.

Odwala okalamba Matenda aimpso osokoneza, motero, mlingo wa metformin uyenera kusankhidwa malinga ndi kuwunika kwa impso, komwe kuyenera kuchitidwa pafupipafupi.

Mankhwala omwe amachepetsa ukalamba ali kale mu mankhwala: nthano kapena zenizeni?

Ndi anthu ochepa omwe amadziwa, koma mankhwalawa okalamba ali kale m'mafakisi. Asayansi atsimikizira kuti mankhwalawa omwe amapangidwa kuti athandizire mafupa amachepetsa kwambiri njira zowonongeka. M'milandu yowonetsera mankhwala, mutha kuipeza mosavuta pansi pa dzina la Zoledronate. Akatswiri amakhulupirira kuti zimawonjezera nthawi yozungulira ya maselo a tebulo. Chifukwa cha izi, ntchito yogwira ntchito imakulanso, yomwe, monga mukudziwa, imachepetsa kwambiri ndi zaka. Masiku ano, asayansi akukonzekera maphunziro angapo ndikuwonetsa kuti mankhwala a mafupa amathandizira kuti munthu akhale ndi moyo wautali.

Ngakhale kuti mankhwalawa amakalamba kale m'mafakitale, tikulimbikitsa kuti tisagwiritse ntchito zina. Itha kuvulaza thupi lanu.

Folk yothetsera kukalamba

Monga tanena kale, mankhwala a Altai okalamba atha kugulitsidwa osachepera zaka ziwiri. Ngati mukufuna kukhalabe ndi unyamata wanu lero, mutha kugwiritsa ntchito mankhwala achikhalidwe, zomwe mungapeze mu nkhani yathu.

Kuti mupange, muyenera kusakaniza uchi 300 uchi, 200 magalamu a mandimu omwe mwangoyamba kumene ndi magalamu 100 amafuta. Timalimbikitsa kugwiritsa ntchito osakaniza tsiku lililonse, supuni imodzi mkati. Sungani elixir chotere mufiriji. Chifukwa cha wowerengeka, mawonekedwe anu adzasintha, makwinya ambiri adzatha ndipo chitetezo chokwanira chidzauka. Izi zimathandizira aliyense. Ngati mukusokonezeka ndi chimodzi mwa zosakaniza zamankhwala, tikukulimbikitsani kuti musakane kugwiritsa ntchito mankhwalawa.

Diso lodana ndi ukalamba

Zaka ziwiri zapitazo, asayansi aku America adayesa madontho amaso aku Russia. Adapeza kuti Visomitin ndimachiritso okalamba. Ndiwo madonthawa omwe samangowonjezera minyewa yamaso, komanso kubwezeretsa maselo ake. Pachifukwachi, asayansi aku America akufuna kupanga chida chomwe chitha kupangitsanso thupi lonse.

Pakadali pano, akatswiri adachita kuyesa pa makoswe. Mtsogolomu, asayansi akukonzekera kulemba anthu odzipereka zana limodzi kuti akayeze kwambiri mankhwala osokoneza bongo. Akutsimikiza kuti posachedwa aliyense adzakhala ndi moyo wabwino kwambiri.

Ukalamba wotsika mtengo

Tsoka ilo, chithandizo cha ukalamba chikupangika. Komabe, asayansi apeza chida chotsika mtengo chomwe chingapangire anthu okalamba kusintha thanzi lawo ndi kutalikitsa moyo. Ndi anthu ochepa omwe amadziwa, koma mafuta a nsomba, omwe amadziwika kwa aliyense kuyambira ali mwana, ndi chinthu chabwino kwambiri chomwe chimachedwetsa kuwonongeka mthupi. Chodabwitsa ndichakuti, m'maiko momwe nyanja kapena nyanja iliko, magwero ndi mavitamini ndi mchere wotere amatengedwa moyo wonse.

Asayansi atsimikizira kuti mwa anthu otere, poyerekeza ndi Russian Federation, chiopsezo cha matenda amtima chambiri chimachepa. Kuphatikiza apo, samakhala ndi mwayi wokhudzana ndi sclerosis komanso vuto lama neva. Ndi anthu ochepa omwe amadziwa, koma ku United States, mafuta a nsomba amalembetsedwa ngati mankhwala. Izi sizinachitike mwangozi, chifukwa anthu kumeneko amagwiritsa ntchito tsiku lililonse la mibadwo iliyonse. Mafuta a nsomba ali ndi phindu lalikulu m'thupi lathu. Zimakuthandizani kuti muchepetse kutupa komwe kumalumikizana, komanso ndilothandiza kwambiri painkiller. Ndi mafuta am'madzi omwe ali ndi kuchuluka kwakukulu kwa ma asidi omwe ali ofunikira m'thupi - Omega-3.

Chodabwitsa, chida, chodziwika bwino kwa aliyense kuyambira ali mwana, chitha kuthandizanso kuthana ndi vuto loyipa. Izi sizomwe zimachitika mwangozi, chifukwa mafuta a nsomba ali ndi zomwe zimapangidwa "mahomoni achisangalalo" - serotonin. Madokotala amalimbikitsa mwamphamvu kuti anthu achikulire aziphatikiza mafuta a nsomba muzakudya zawo. Zingathandize osati kuthana ndi mavuto ambiri, komanso kupewa matenda ambiri oyamba.

Ndikofunika kudziwa kuti palibe chizolowezi chakhazikitsidwa tsiku lililonse chakumwa mankhwalawa. Amasankhidwa payekha. Mutha kudziwa mosavuta izi kuchokera kwa dokotala. Mafuta a nsomba ndimachiritso okalamba, omwe samangokhala pagulu la anthu, komanso otchipa. Timalimbikitsa kwambiri kuphatikiza muzakudya zanu.

Mankhwala olimbana ndi ukalamba wa Altai kuti muthane ndi vuto la kubereka

Asayansi a Altai adayesa mayeso ambiri. Adapeza kuti njira yothandizira kukalamba imathandiza kuthana ndi chiwonongeko chokha, komanso matenda a chiwindi. Kodi mankhwalawa ali ndi zowonjezera zina?

Chodabwitsa, asayansi a Altai adazindikira kuti mankhwala awo amtsogolo azithandizira pobala anthu osabereka. Monga tidanenera kale, ntchito yayikulu ya mankhwalawa ndikukonza maselo. Pochita zoyesa pa makoswe, akatswiri adadzala mazira aanthuza. Modabwitsa, 99% ya maselo omwe adayambitsawo sanangokhala ndi moyo, komanso adakula kukhala makoswe akuluakulu. Mtsogolomo, omwe amapanga mankhwalawa amakonzekereranso ngati njira yothandizira kubereka.

Chozizwitsa chodabwitsa cha mankhwala a Altai. Mtengo wamankhwala

Monga tanena kale, asayansi a Altai adayesa mankhwalawo osati pa mbewa zokha, komanso pa iwo eni. Mmodzi mwa akatswiri anali ndi matenda osachiritsika omwe amayambitsidwa ndi adhesions. Pambuyo kanthawi, atagwiritsa ntchito mankhwalawa pafupipafupi, adazichotsa. Pachifukwa ichi, omwe amapanga mankhwalawa amati ali ndi mikhalidwe yabwino kuposa momwe amaganizira. Mtsogolomo, asayansi akukonzekera kuyesera zingapo zomwe zingathandize kudziwa zomwe zimapangitsa, kuwonjezera pa kukonzanso, kumanyamula mankhwala awo.

Mtengo wa mankhwala amtsogolo osadziwika. Opanga amalonjeza kuti azichita zonse zomwe zingatheke kuti ikhale yotsika momwe angathere. Komabe, akugogomezera kuti mtengo wake udzakhudzana mwachindunji ndi kuchuluka kwa ma batchi omwe atulutsidwa.

Mwachidule

Lero, mankhwala ochiritsira okalamba asayansi a Altai akupangika. Mwinanso, patatha zaka zingapo, titha kugula mankhwala osavuta ngati awa ku pharmacy. Monga tanena kale, ndizotheka kuti zithandiza kuthana ndi chiwonongeko, komanso matenda ena akuluakulu. Ndipo pamene mankhwalawa akukula, tikukulimbikitsani kuti mukhalebe ngati thupi lanu pogwiritsa ntchito njira zina. Musanagwiritse ntchito mankhwala aliwonse, onetsetsani kuonana ndi dokotala. Khalani athanzi!

Metformin ndi mankhwala omwe amatalikitsira moyo.

Zatsimikiziridwa mwasayansi kuti mankhwalawa Metformin, omwe amawerengedwa kwa anthu omwe ali ndi matenda osokoneza bongo a insulin, amatha kuchepetsa kukalamba ndikupatsa moyo.

Metformin (mayina amalonda - Glucofage, Glucomin, Siofor, Metformin) amakupatsani mwayi wowonjezera moyo wanu chifukwa cha zinthu zotsatirazi zomwe mankhwalawa amapangira:

Kodi mankhwalawa amalembedwera chiyani?

Zizindikiro zomwe zimagwiritsidwa ntchito ndi mtundu wa shuga wachiwiri, komanso mtundu wa 1 shuga, wovuta kwambiri chifukwa cha kunenepa kwambiri komanso kukana insulin. Komabe, anthu ambiri amatenga metformin kuti achepetse thupi kuposa kuchiritsa matenda ashuga. Komanso, mankhwalawa amathandizira ndi polycystic ovary syndrome (PCOS) mwa amayi, amawonjezera mwayi wokhala ndi pakati. Kugwiritsa ntchito metformin pakuchepetsa thupi komanso kuwongolera shuga kumafotokozedwa mwatsatanetsatane pansipa.

Mutu wamankhwala a PCOS ndi woposa tsambali. Amayi omwe akumana ndi vutoli, muyenera kupita, kukachita maphunziro akuthupi, kumwa mankhwala ndikutsatira malangizowo. Kupanda kutero, adzakhala ndi mwayi wochepa wokhala ndi pakati komanso chiwopsezo chachikulu chokhala ndi matenda osokoneza bongo a 2 zaka zopitilira 35-40.

Kodi Metformin Ikulitsa Moyo?

Metformin imachulukitsa moyo wa odwala omwe ali ndi matenda a shuga a 2, amachedwa kukulitsa zovuta zawo. Sizinatsimikiziridwebe kale kuti mankhwalawa amathandiza anthu athanzi ndi shuga wabwinobwino wamagazi kuyambira kukalamba. Kafukufuku wovuta pankhaniyi wayamba kale, koma zotsatira zake sizipezeka posachedwa. Komabe, anthu ambiri odziwika ku West adavomereza kuti amavomereza, kuyesera kuti achepetse ukalamba wawo. Adasankha kuti asadikire chitsimikiziro chovomerezeka.

Dokotala wodziwika komanso wowonetsa TV pa TV Elena Malysheva amalimbikitsanso kuti mankhwalawa ndi mankhwala ngati ukalamba.

Oyang'anira tsambali amaganizira za chiphunzitso cholimbikitsa chakuti metformin imachepetsa ukalamba, makamaka kwa anthu onenepa kwambiri. Elena Malysheva nthawi zambiri amafalitsa zinthu zolakwika kapena zachikale. Mankhwala omwe amawauza omwe samalankhula sawathandiza konse. Koma pankhani ya metformin, munthu angavomereze naye. Ichi ndi mankhwala othandiza kwambiri, ndipo popanda zovuta zoyipa, ngati mulibe zotsutsana nawo.

Kodi metformin ingatengedwe kuti ipewe? Ngati ndi choncho, mu milingo iti?

Ngati muli ndi kulemera pang'ono pang'ono, ndizomveka kutenga metformin kuti mupewe, kuyambira zaka zapakati. Mankhwalawa athandizira kuchepa makilogalamu ochepa, kusintha mafuta m'thupi, komanso kuchepetsa ngozi ya matenda ashuga a 2.

Musanayambe kumwa mapiritsi awa, phunzirani mosamala, makamaka magawo pazinthu zotsutsana ndi zoyipa.

Palibe deta yeniyeni pazaka zomwe mungayambe kutenga metformin. Mwachitsanzo, zaka 35 mpaka 40. Kumbukirani kuti chithandizo chachikulu ndi ichi. Mapiritsi aliwonse, ngakhale okwera mtengo kwambiri, amatha kungoonjezera zomwe chakudya chimakhala nacho mthupi lanu. Zakudya zoziziritsa kukhosi ndizowopsa. Palibe mankhwala oyipa omwe angabwezeretse zotsatira zawo zoyipa.

Anthu onenepa amalangizidwa kuti pang'onopang'ono abweretse kuchuluka kwa mankhwalawa tsiku lililonse - 2550 mg patsiku kwa mankhwala omwe amapezeka nthawi zonse ndi 2000 mg kwa mapiritsi otulutsidwa (ndi ma analogues). Yambani kumwa 500-850 mg patsiku ndipo musathamangire kuti muwonjezere mlingo kuti thupi likhale ndi nthawi yosinthira.

Tiyerekeze kuti mulibe kulemera kwambiri konse, koma mukufuna kutenga metformin kuti mupewe kusintha komwe kumayenderana ndi zaka. Pankhaniyi, sibwino kugwiritsa ntchito muyeso wokwanira. Yesani 500-1700 mg patsiku. Tsoka ilo, palibe chidziwitso chokwanira pamiyeso yolimbana ndi kukalamba ya anthu ochepa thupi.

Kodi ndimwe mankhwalawa kuti ndikhale ndi prediabetes?

Inde, metformin imakuthandizani ngati mukunenepa kwambiri, makamaka mafuta osunga pamimba komanso m'chiuno. Kuchiza ndi mankhwalawa kumachepetsa mwayi woti prediabetes isanduke mtundu 2 shuga.

Muyenera kutenga metformin kuti muchepetse thupi malinga ndi malingaliro omwe afotokozedwa patsamba lino, ndikuwonjezereka pang'onopang'ono kwa mlingo watsiku ndi tsiku. Werengani mosamala ndikuonetsetsa kuti mulibe zotsutsana ndi kugwiritsa ntchito chida ichi. Ndikofunika kubwerezanso kuti mafuta a hepatosis sikuti akuphwanya.

Kodi mungatani kuti muchepetse makilogalamu angati kuchokera ku metformin?

Mutha kuyembekezera kutaya makilogalamu 2-4 ngati simusintha kadyedwe kanu komanso kuchuluka kwa zolimbitsa thupi. Zitha kukhala mwayi kuti muchepetse kulemera kochulukirapo, koma palibe malonjezo.

Tikubwerezanso kuti metformin ndi mankhwala okhawo omwe amathandizira kuchepetsa thupi popanda kuvulaza thanzi. Ngati pakadatha masabata asanu ndi limodzi atatha kumwa, sizotheka kuthana ndi mapaundi owonjezera owerengeka - ambiri, munthu amakhala ndi kuchepa kwa mahomoni a chithokomiro. Yesani kuyezetsa magazi kwa mahomoni onsewa, osaperekedwa ndi TSH. Chofunikira kwambiri ndi T3 yaulere. Kenako funsani ndi endocrinologist.

Mwa anthu omwe amasinthira, zotsatira za kuchepa thupi zimakhala bwino. Ambiri mwa malingaliro awo amalemba kuti adatha kutaya 15 kg kapena kupitirira. Muyenera kumwa metformin mosalekeza kuti muzisunga zotsatira zomwe mwakwaniritsa. Mukasiya kumwa mapiritsi awa, ndiye kuti gawo lina la mapaundi owonjezera ayenera kubwerera.

Elena Malysheva adapangitsa kuti metformin ikhale yotchuka ngati machiritso a ukalamba, koma samalimbikitsa monga njira yothandizira kunenepa kwambiri. Amalimbikitsa makamaka kudya kwake kuti achepetse thupi, osati mapiritsi ena ake. Komabe, chakudyachi chili ndi zakudya zambiri zomwe zimadzaza ndi chakudya chamafuta. Amachulukitsa kuchuluka kwa insulin m'magazi motero amalepheretsa kuchepa kwamafuta mthupi.

Zambiri pazamankhwala a shuga ndi kuwonda, zomwe zimagawidwa ndi Elena Malysheva, ndizambiri zomwe sizolondola.

Momwe mungasinthire metformin ngati sichithandiza matenda ashuga kapena amayambitsa kutsegula m'mimba?

Metformin siivuta kusinthana ndi china chake, ndimankhwala ambiri mwanjira zosiyanasiyana. Popewa kutsekula m'mimba, muyenera kumwa mapiritsi ndi chakudya, kuyamba ndi mlingo wotsika tsiku ndi tsiku ndikuwonjezera pang'onopang'ono. Mutha kuyesanso kwakanthawi kusintha kuchokera pamapiritsi a nthawi zonse kupita ku mankhwala omwe akhala akuchita kwa nthawi yayitali. Ngati metformin sichepetsa shuga m'magazi konse - ndikotheka kuti wodwalayo ali ndi matenda a shuga a 2 apamwamba kwambiri, omwe adasanduka mtundu 1 wa shuga. Pankhaniyi, muyenera kuyambitsa jakisoni mwachangu, palibe mapiritsi omwe angakuthandizeni.

Mu odwala matenda ashuga, metformin amachepetsa shuga, koma sikokwanira. Pankhaniyi, iyenera kuphatikizidwa ndi jakisoni wa insulin.

Kumbukirani kuti anthu owonda nthawi zambiri samatha kumwa mapiritsi a shuga. Afunika kusinthira ku insulin nthawi yomweyo. Kukhazikitsidwa kwa mankhwala a insulin ndi vuto lalikulu, muyenera kumvetsetsa. Nkhani zophunzira za insulin patsamba lino, funsani ndi dokotala. Choyamba, pitani. Popanda icho, kudziletsa pazabwino ndikosatheka.

Njira zochokera ku gulu la Biguanide zakhala zikugwiritsidwa ntchito kuyambira kalekale pochiza matenda amtundu wa 2 shuga. Komabe, mankhwalawa ali ndi mavuto ambiri. Kodi izi zikutanthauza kuti metformin ndi yopanda thanzi, chifukwa ndi iye amene amapanga mankhwala mwanjira iyi?

Masiku ano, zinthu zatsopano za chinthuchi zikupezeka ndipo kugwiritsa ntchito kwake kukukulira mokwanira, pogwiritsa ntchito mankhwalawa osati mu zovuta kuchipatala.

Mankhwala Metformin akhala akugwiritsidwa ntchito ngati kale pofuna kuchiza matenda am'mimba a shuga 2 molumikizana ndi zakudya zomwe dokotala wakupatsani. Zimangolimbikitsa kusintha shuga m'magazi, komanso zimathandizira kuchepetsa kunenepa kwambiri, zomwe ndizofunikira kwambiri kwa anthu omwe ali ndi vutoli.

Mpaka pano, mawonekedwe ena a mankhwalawo adadziwika. Zakhazikitsidwa zasayansi kuti munthu atha kutenga Metformin kuti akwaniritse zolinga izi:

1. Imathandizira kuteteza ubongo ku ukalamba, womwe umalola kuti uzigwiritsira ntchito prophylactic zolinga motsutsana ndi matenda a Alzheimer's.
2. Mosangalatsa zimakhudza mitsempha yamagazi ndi mitsempha. Chifukwa chake, mothandizidwa ndi Metformin, kukula kwa mitsempha ya mitsempha, kulephera kwa mtima, matenda oopsa, kuletsa mtima kwamankhwala kumatha kupewedwa.
3. Amachepetsa mwayi wokhala ndi khansa.
4. Amathandizira kusintha kwa potency mwa abambo, omwe anali ndi vuto chifukwa cha matenda osiyanasiyana a senile.
5. Zimalepheretsa kukula kwa mafupa a anthu odwala matenda ashuga. Makamaka, nthawi zambiri, azimayi amakhala ndi vuto la mafupa osaneneka atasiya kusamba, popeza pali kuchepa kwakukulu kwamahomoni - estrogen.
6. Zokhudza bwino chithokomiro cha chithokomiro.
7. Ili ndi ntchito yoteteza mokhudzana ndi dongosolo la kupuma.

Ngakhale kuti mankhwalawa ali ndi zabwino zambiri, sizingatheke kunena kuti ndi athanzi ndipo amatha kuchiritsa matenda ambiri. Monga zida zina zamankhwala, Metformin ikhoza kugwiritsidwa ntchito molingana ndi madokotala omwe amapita, poganizira kuti chiwonetsero cha zovuta zake zonse ndi zotsutsana.