Thiogamma analogues

Thiogamma ndi mankhwala a antioxidant komanso metabolic omwe amawongolera chakudya cham'mimba komanso lipid metabolism.

Zomwe zimagwiritsa ntchito mankhwalawa ndi thioctic (alpha-lipoic) acid. Ndi ma antioxidant amkati omwe amamangirira zopitilira muyeso. Thioctic acid imapangidwa m'thupi nthawi ya oxidative decarboxylation ya alpha-keto acid.

Thioctic acid amawongolera chakudya komanso lipid metabolism, imakhudza ntchito ya chiwindi komanso imathandizira kagayidwe ka cholesterol. Ili ndi hypolipidemic, hypoglycemic, hepatoprotective ndi hypocholesterolemic kwenikweni. Chimalimbikitsa thanzi la neurons.

Alpha-lipoic acid imathandizira kuchepetsa shuga m'magazi, kuonjezera kuchuluka kwa glycogen m'chiwindi ndikugonjetsa insulin kukana. Mwa makina ochitira, ili pafupi ndi mavitamini a gulu B.

Kafukufuku wokhudza makoswe omwe ali ndi matenda a shuga a streptozotocin adawonetsa kuti asidi wa thioctic amachepetsa mapangidwe a glycation omaliza, amasintha magazi am'magazi, ndikuwonjezera kuchuluka kwa antioxidants achilengedwe monga glutathione. Umboni waukadaulo umati thioctic acid imathandizira kuti zotumphukira za neuron zizigwira ntchito.

Izi zimagwira ntchito pazovuta zamatenda a matenda ashuga polyneuropathy, monga dysesthesia, paresthesia (kuwotcha, kupweteka, kukwawa, kuchepa mphamvu). Zotsatira zake zimatsimikiziridwa ndi mayesero azachipatala a multicenter omwe adachitika mu 1995.

Mitundu yotulutsidwa kwa mankhwalawa:

• Mapiritsi - 600 mg yogwira ntchito iliyonse,
• Njira yothetsera makulidwe a makolo 3%, ampoules a 20 ml (mu 1 ampoule 600 mg yogwira ntchito),
• Thiogamm-turbo - njira yothetsera kulowetsedwa kwa kholo 1.2%, 50 ml Mbale (mu 1 botolo 600 mg yogwira ntchito).

Zizindikiro zogwiritsidwa ntchito

Kodi chimathandizira chiyani Tiogamm? Lembani mankhwalawa mu milandu iyi:

• Matenda a chiwindi chamafuta (mafuta a chiwindi),
• Hyperlipidemia yachidziwitso chosadziwika (mafuta okwera)
• Poyizoni wazipale (kuwonongeka kwa chiwindi),
• Kulephera kwa chiwindi
• Matenda a chiwindi cha chidakwa komanso zotsatira zake,
• Hepatitis kuchokera kulikonse,
• Hepatic encephalopathy,
• Matenda a chiwindi.

Malangizo ogwiritsira ntchito Thiogamm, mlingo

Mapiritsi amatengedwa pakamwa, pamimba yopanda kanthu, kutsukidwa ndi madzi pang'ono.

Mlingo woyenera ndi piritsi limodzi la Tiogamma 600 mg 1 nthawi patsiku. Kutalika kwa matendawa kumatengera kutha kwa matendawa ndipo kuyambira 30 mpaka 60 masiku.

M'chaka, njira ya mankhwalawa imatha kubwerezedwa katatu.

Zingwe

Mankhwala chikuyendetsedwera iv muyezo wa 600 mg / tsiku (1 amp. Gwiritsirani ntchito pokonzekera yankho la kulowetsedwa kwa 30 mg / ml kapena 1 botolo la yankho la kulowetsedwa kwa 12 mg / ml).

Kumayambiriro kwa maphunzirowa, ndikulimbikitsidwa kuti liperekedwe kwa milungu iwiri kapena itatu. Kenako mutha kupitiliza kumwa mankhwala mkati mwa 300-600 mg / tsiku.

Mukamayambitsa kulowetsedwa kwa mtsempha, mankhwalawa amayenera kuperekedwa pang'onopang'ono, osaposa 50 mg / min (omwe ali ofanana ndi 1.7 ml ya kuganizira kwambiri pokonzekera yankho la kulowetsedwa kwa 30 mg / ml).

Konzani njira yothetsera kulowetsedwa - zomwe zili mumulu umodzi wa zomwe mukumangirira ziyenera kusakanikirana ndi 50-250 ml ya 0,9% ya sodium kolorayidi. Botolo lomwe lili ndi njira yokonzekereratu limakutidwa ndi vuto lotetezera, lomwe limakhala lathunthu ndi mankhwalawo. Njira yotsirizidwa imatha kusungidwa kwa maola osaposa 6.

Ngati njira yothetsera kulowetsedwa okonzeka itagwiritsidwa ntchito, botolo la mankhwalalo limachotsedwa m'bokosilo ndipo nthawi yomweyo limakutidwa ndi kesi yoteteza. Kuyambitsa kumapangidwa mwachindunji kuchokera m'botolo, pang'onopang'ono - kuthamanga kwa 1.7 ml / miniti.

Zotsatira zoyipa

Thiogamma ikhoza kukhala yokhudzana ndi zotsatirazi:

Kuchokera pamimba: mukamwa mankhwalawa mkati - dyspepsia (kuphatikiza mseru, kusanza, kutentha kwa mtima).

• Kuchokera kumbali ya dongosolo lamkati lamanjenje: kawirikawiri (pambuyo pa kayendetsedwe ka iv) - kupweteka, diplopia, ndikuwongolera mwachangu - kukhudzidwa kwachulukidwe (kuwoneka ngati kolemetsa pamutu).
• Kuchokera pamagazi ophatikizika am'magazi: kawirikawiri (pambuyo pa utsogoleri wa iv) - amaloze zotupa mu mucous nembanemba, khungu, thrombocytopenia, hemorrhagic zidzolo (purpura), thrombophlebitis.
• Kuchokera pamachitidwe opumira: poyambira / poyambitsa, zovuta kupuma ndizotheka.
• Thupi lawo siligwirizana: urticaria, zokhudza zonse zimachitika (mpaka chitukuko cha anaphylactic mantha).
• Ena: hypoglycemia imatha kupezeka (chifukwa cha kutulutsa shuga).

Contraindication

Thiogamma amatsutsana pazochitika zotsatirazi:

• ana ndi achinyamata osakwana zaka 18,
• nthawi yapakati
• Nthawi yonyamula mkaka
• glucose-galactose malabsorption, kuchepa kwa lactase, chibadwa cha galactose tsankho (mapiritsi),
• Hypersensitivity kwa zida zazikulu kapena zothandiza za mankhwalawa.

Poyerekeza ndi momwe mankhwalawo amagwiritsidwira ntchito, mankhwalawa sangatengedwe, popeza mothandizidwa ndi ethanol, mwayi wokhala ndi zovuta kwambiri kuchokera kumitsempha yam'mimba komanso kugaya kwam'mimba kumawonjezereka.

Ma analogi a Thiogma, mtengo pamafakitale

Ngati ndi kotheka, mutha kusintha Thiogamma ndi analogue yogwira ntchito - awa ndi mankhwala:

Posankha analogi, ndikofunikira kumvetsetsa kuti malangizo ogwiritsira ntchito Tiogamma, mtengo ndi kuwunika kwa mankhwala omwe ali ndi zotsatira zofananira sizikugwira ntchito. Ndikofunikira kupeza upangiri wa dokotala komanso kuti usasinthe popanda mankhwala.

Mitengo ku pharmacies aku Moscow: Njira ya Thiogamma 12 mg / ml 50 ml - kuyambira 197 mpaka 209 rubles. Mapiritsi a 600 mg 30 ma PC. - kuchokera ku 793 mpaka 863 ma ruble.

Pewani patali ndi ana, mutetezedwe ndi kuwala, kutentha mpaka 25 ° C. Moyo wa alumali ndi zaka 5. Mankhwala, mankhwala amapezeka.

Ndemanga zitatu za "Tiogamma"

Zimathandiza kwambiri. Amayi amaponyera mankhwalawa kawiri pachaka. Pambuyo pakugwiritsa ntchito, akumva bwino kwambiri!

Ndinapatsidwa dontho lokhala ndi thiagia nthawi ya 14.00 masana, ndipo nthawi ya 24.00 usiku kupsinjika kunakwera kufika 177 pofika 120. Mutu wanga udawawa kwambiri, ndimaganiza kuti udzaphulika. Mwanjira inayake adadzetsa kupsinjika kwa aKorff ndi Kapoten. Ndidazindikira kuti kutereku kumachitika pa tiagammu 🙁

Katswiri wamtima adapereka mankhwala a lipoic acid kwa mwana wake, koma osati mankhwalawa.

Analogs popanga ndi chisonyezo chogwiritsidwa ntchito

Mndandanda womwe uli pamwambapa wa analogies ya mankhwala, omwe akuwonetsa Thiogammala, ndizabwino kwambiri chifukwa zimakhala ndi zinthu zomwe zimagwirizana ndipo zimagwirana molingana ndi chisonyezo chogwiritsidwa ntchito

Analogs mwa chisonyezo ndi njira yogwiritsira ntchito

Kuphatikizika kosiyanasiyana, kungagwirizane mukuwonetsa ndikugwiritsa ntchito njira

Kodi mungapeze bwanji analogue yotsika mtengo ya mankhwala okwera mtengo?

Kuti mupeze analogue yotsika mtengo kwa mankhwala, a generic kapena ofanana, choyambirira timalimbikitsa kulabadira kapangidwe kake, zomwe ndi zinthu zomwezi zomwe zikugwiritsidwa ntchito ndikuwonetsa. Zomwe zimagwiritsidwanso mosiyanasiyana ndi mankhwalawa zimawonetsa kuti mankhwalawo ndi ofanana ndi mankhwalawo, monga mankhwala ena kapena mitundu ina ya mankhwala. Komabe, musaiwale za zovuta zomwe zimagwiritsidwa ntchito ndi mankhwala ofanana, omwe angakhudze chitetezo ndi kugwiranso ntchito. Musaiwale za upangiri wa madotolo, kudzipereka nokha kungawononge thanzi lanu, chifukwa chake onani dokotala wanu musanagwiritse ntchito mankhwala.

Malangizo a Tiogamm

MALANGIZO
pa kugwiritsa ntchito mankhwalawa
Tiogamma

Zotsatira za pharmacological
Pulogalamu yogwira Thiogamm (Thiogamma-Turbo) ndi asidi wa thioctic (alpha-lipoic). Thioctic acid imapangidwa m'thupi ndipo imagwira ntchito ngati coenzyme yopanga mphamvu ya alpha-keto acid ndi oxidative decarboxylation. Thioctic acid imayambitsa kutsika kwa glucose mu seramu yamagazi, imathandizira kuti glycogen ichulukane mu hepatocytes. Mavuto a metabolism kapena kusowa kwa thioctic acid amawonedwa ndikuchulukitsidwa kwambiri kwa metabolites ena mthupi (mwachitsanzo, matupi a ketone), komanso ngati atamwa. Izi zimabweretsa zosokoneza mu unyolo wa aerobic glycolysis. Thioctic acid ilipo mthupi mu mawonekedwe a mitundu iwiri: yochepetsedwa ndikuwonjezeredwa. Mitundu yonseyi ndi yogwira ntchito mwakuthupi, imapereka antioxidant komanso anti-sumu.
Thioctic acid amawongolera kagayidwe kazakudya ndi mafuta, zimakhudza kagayidwe ka cholesterol, imakhala ndi hepatoprotective, ikukhudza ntchito ya chiwindi. Zothandiza pa obwezeretsanso njira mu minofu ndi ziwalo. Mankhwala okhala ndi thioctic acid ndi ofanana ndi mavitamini a B. Pamugawo woyamba wa chiwindi, thioctic acid amasintha kwambiri. Mwa kupezeka kwa mankhwalawa, kusinthasintha kwakukulu kumawonedwa.
Ikagwiritsidwa ntchito mkati, imathamanga ndipo imatsala pang'ono kulowa m'mimba. Metabolism imapitilira ndi kukhathamiritsa kwa mbali ya thioctic acid ndi kuphatikizika kwake. Kutha kwa theka-moyo wa Tiogamm (Tiogamm-Turbo) kuyambira 10 mpaka 20 mphindi. Amachotsedwa mu mkodzo, ndi metabolites of thioctic acid predominating.

Zizindikiro zogwiritsidwa ntchito
Ndi diabetesic neuropathy kusintha minofu kumva.

Njira yogwiritsira ntchito
Thiogamm-Turbo, Thiogamm wa kasamalidwe ka makolo
Thiogamm-Turbo (Thiogamma) cholinga chake ndi kuwongolera makolo mwa kulowetserera mtsempha wamagetsi. Kwa akuluakulu, mlingo wa 600 mg (zomwe zili mu 1 vial kapena 1 ampoule) zimagwiritsidwa ntchito kamodzi patsiku. The kulowetsedwa ikuchitika pang'onopang'ono, kwa mphindi 20-30. Njira yochizira matendawa ndi pafupifupi milungu iwiri kapena inayi. M'tsogolomu, kugwiritsa ntchito kwa Tiogamma m'mapiritsi kumalimbikitsidwa. Makulidwe a Pareogeral a Thiogamma-Turbo kapena Thiogamm kulowetsedwa amalembera matenda osokoneza bongo omwe amayamba chifukwa cha matenda ashuga a polyneuropathy.

Malamulo okhudzana ndi makolo pa Thiogamm-Turbo (Thiogamm)
Zomwe zili m'botolo 1 la Thiogamma-Turbo kapena 1 ampoule wa Thiogamma (600 mg wa mankhwalawa) zimasungunuka mu 50-250 ml ya yankho la 0.9% sodium chloride. Mlingo wa kulowetsedwa kwa mtsempha - osapitirira 50 mg ya thioctic acid mu miniti imodzi - izi zikufanana ndi 1.7 ml ya yankho la Tiogamma-Turbo (Tiogamm). Kukonzekera kuchepetsedwa kuyenera kugwiritsidwa ntchito mukangosakaniza ndi zosungunulira. Pa kulowetsedwa, njira yothetsera vutoli iyenera kutetezedwa ndikuwala ndi chinthu chapadera choteteza kuwala.

Tiogamma
Mapiritsiwo adapangira kuti azigwiritsa ntchito mkati. Ndi bwino kupereka mankhwala a 600 mg kamodzi pa tsiku. Piritsi liyenera kumezedwa lonse, litenge popanda chakudya, kutsukidwa ndi madzi okwanira. Kutalika kwa mankhwalawa kwa mapiritsi kuyambira 1 mpaka miyezi 4.

Zotsatira zoyipa
Central mantha system: nthawi zina, mutagwiritsa ntchito mankhwalawa kulowetsedwa, kupindika kwamisempha kumatheka.
Zokhudza ziwalo: kuphwanya tanthauzo la kukoma, diplopia.
Hematopoietic dongosolo: purpura (hemorrhagic zidzolo), thrombophlebitis.
Hypersensitivity reaction: systemic zochita zimatha kuyambitsa anaphylactic, eczema kapena urticaria pamalo a jekeseni.
Dongosolo logaya (la mapiritsi a Tiogamm): mawonetseredwe a dyspeptic.
Zina: ngati Thiogamm-Turbo (kapena Thiogamm wa makolo achitetezo) akaperekedwako mwachangu, kupuma kwamphamvu ndi kumverera kovutikira m'mutu ndikotheka - izi zimayima pambuyo pakuchepa kwa kulowetsedwa. Zothekanso: hypoglycemia, kutentha kwa moto, chizungulire, thukuta, kupweteka mumtima, kutsika magazi, kutsukidwa, kuwona kwamaso, mutu, kusanza, tachycardia.

Contraindication
• Zinthu zodwala zomwe zimayambitsa kukhazikika kwa lactic acidosis (kwa Thiogamma-Turbo kapena Thiogamm wa makasitomala),
• Ana
• nthawi ya mimba ndi mkaka wa m`mawere,
• thupi lawo siligwirizana ndi thioctic acid kapena zinthu zina za Thiogamm (Thiogamm-Turbo),
• kwambiri kwa chiwindi kapena kuwonongeka kwa impso,
• siteji yovuta kwambiri yamatenda amchere,
• kuwonongeka kwa kupuma kapena mtima kulephera,
• kusowa kwamadzi,
• uchidakwa wopitilira,
• pachimake cerebrovascular ngozi.

Mimba
Pa nthawi yoyembekezera kapena yoyamwitsa, kugwiritsa ntchito kwa Thiogamma ndi Thiogamm-Turbo sikulimbikitsidwa, popeza palibe chidziwitso chokwanira chachipatala chodziwitsa mankhwala.

Kuyanjana kwa mankhwala osokoneza bongo
Kuchita bwino kwa mankhwala a hypoglycemic ndi insulin kumakulitsidwa limodzi ndi Thiogamma (Thiogamma-Turbo). Njira ya Thiogamm-Turbo kapena Thiogamm sigwirizana ndi zosungunulira zomwe zimakhala ndi mamolekyu a glucose, chifukwa thioctic acid imapangika m'magulu a shuga. Pakuyesera kwa vitro, thioctic acid imachitika ndi zitsulo zazitsulo. Mwachitsanzo, pawiri wokhala ndi chisplantine, magnesium, ndi chitsulo amatha kuchepetsa zomwe zimachitika pakuphatikizidwa ndi thioctic acid. Ma sol sol omwe ali ndi zinthu zomwe zimalumikizana ndi disulfide mankhwala kapena magulu a SH sagwiritsidwa ntchito kuti athetse njira ya Thiogamma-Turbo (Thiogamma) (mwachitsanzo, yankho la Ringer).

Bongo
Ndi mankhwala osokoneza bongo a Tiogamm (Tiogamm-Turbo), kupweteka mutu, kusanza, ndi mseru ndizotheka. Mankhwalawa ndi chizindikiro.

Kutulutsa Fomu
Tiogamm Turbo
Yankho la kulowetsedwa kwa maberekedwe mu mamililita 50 (1.2% thioctic acid). Mu phukusi - 1, mabotolo 10. Milandu yapadera yopanda magetsi.

Mapiritsi a Tiogamm
Mapiritsi a 600 mg omwe ali ndi ntchito mkati. Mu phukusi la 30, mapiritsi 60.

Thiogamma yankho la kulowetsedwa
Njira yothetsera makulidwe a makolo m'magawo 20 ml (3% thioctic acid). Mu phukusi - 5 ampoules.

Malo osungira
Pamalo omwe amatetezedwa ku kuwala, kutentha kwa 15 mpaka 30 digiri Celsius. Njira yothetsera kulowetsedwa mwaubongo siyikusungidwa. Ampoules ndi Mbale ziyenera kungokhala pazoyikapo zoyambirira.

Kupanga
Tiogamm Turbo
Zogwira ntchito (50 ml): thioctic acid 600 mg.
Zowonjezera: madzi a jakisoni, macrogol 300.
50 ml ya njira ya kulowetsa kwa Tiogamma-Turbo ili ndi mchere wa meglumine wa alpha-lipoic acid wambiri 1167.7 mg, womwe umafanana ndi 600 mg wa thioctic acid.
Tiogamma
Zothandiza (piritsi limodzi): thioctic acid 600 mg.
Zowonjezera: colloidal silicon dioxide, cellcrystalline cellulose, talc, lactose, methylhydroxypropyl cellulose.
Tiogamma
Zogwira ntchito (20 ml): thioctic acid 600 mg.
Zowonjezera: madzi a jakisoni, macrogol 300.
20 ml ya njira ya kulowetsa kwa Tiogamma imakhala ndi mchere wa meglumine wa alpha-lipoic acid wambiri 1167.7 mg, womwe umafanana ndi 600 mg wa thioctic acid.

Gulu la mankhwala
Mahormone, analogues awo ndi antihormonal mankhwala
Mankhwala okhala ndi pancreatic mahomoni ndi mankhwala opangira hypoglycemic
Synthetic hypoglycemic wothandizira

Zogwira ntchito: Thioctic acid

Zosankha
Pamabotolo okhala ndi a Thiogamm-Turbo osungunuka, milandu yapadera yoteteza kuunika imayikidwa, yomwe imaphatikizidwa ndi mankhwalawa. Njira ya Thiogamm imatetezedwa ndi zida zoteteza. Mankhwalawa odwala, kuchuluka kwa shuga wa seramu kuyenera kuyesedwa pafupipafupi, malinga ndi momwe mlingo wa insulin ndi mankhwala a hypoglycemic ayenera kusinthidwira kuti mupewe hypoglycemia. Ntchito zochizira thioctic acid zimachepetsedwa kwambiri ndi mowa (ethanol). Palibe chenjezo lina lofunikira.

Omwe Amapezeka Mapulogalamu a Thiogamm

Lipoic acid (mapiritsi) Kutalika: 42

Analogue ndiotsika mtengo kuchokera ku ma ruble 872.

Lipoic acid ndiye wogula wotsika mtengo kwambiri wa Tiogamm mu gulu lawo lazachipatala. Amapezeka mu mawonekedwe a mapiritsi okhala ndi mitundu yambiri ya DV. Mapiritsi okhala ndi mulingo wofika 25 mg amadziwika kuti mafuta a chiwindi, chiwindi matenda enaake, matenda a chiwindi ndi kuledzera.

Analogue ndiotsika mtengo kuchokera ku ma ruble 586.

Oktolipen - mankhwala ena achi Russia, omwe amapindulitsa kwambiri kuposa "choyambirira". Apa DV yemweyo (thioctic acid) imagwiritsidwa ntchito mu Mlingo wa 300 mg pa kapisozi iliyonse. Zizindikiro ntchito: matenda ashuga ndi mowa.

Tialepta (mapiritsi) Kukala: 29 Pamwamba

Analogue ndiotsika mtengo kuchokera ku ma ruble 548.

Tiolepta ndi mankhwala ochizira matenda am'mimba, kutengera zochita za thioctic acid omwe ali mgulu lofanana ndi mankhwala ena omwe aperekedwa patsamba lino. Ili ndi mndandanda womwewo wazisonyezo zakusankhidwa kwake. Zotsatira zoyipa ndizotheka.

Pharmacokinetics

Mukamamwa pakamwa, imayamba msanga komanso kukhathamiritsa kwathunthu, ndipo kudya nthawi yomweyo ndi chakudya kumachepetsa kuyamwa. Bioavailability ndi 30-60% chifukwa cha gawo loyambira kudzera pachiwindi. Tmax pafupifupi 30 min, Cmax - 4 μg / ml.

Ndi pa / pakukhazikitsa Tmax - 10-11 mphindi, Cmax ili pafupifupi 20 μg / ml.

Imakhala ndi mphamvu yoyambira kudutsa m'chiwindi. Iwo zimapukusidwa mu chiwindi ndi mbali unyolo wa oxidation ndi conjugation. Chilolezo chonse cha plasma ndi 10-15 ml / min. Thioctic acid ndi metabolites ake amuchotseredwa ndi impso (80-90%), pang'ono - osasinthika. T1 / 2 - 25 min.

Njira yogwiritsira ntchito

Tsatirani njira yothetsera kulowetsedwa ndi njira yothetsera kulowetsedwa kwa Thiogamm

Mu / mu, mawonekedwe a infusions, kutumikiridwa pang'onopang'ono (kupitirira mphindi 30) pa mlingo wa 600 mg / tsiku. Njira yovomerezedwera yogwiritsira ntchito ndi masabata 2-2. Kenako, mutha kupitiliza kumwa mankhwalawa a mankhwalawa a mankhwala a Tiogamm pa mlingo wa 600 mg / tsiku.

Mbale yokhala ndi yankho la kulowetsedwa imachotsedwa m'bokosilo ndipo nthawi yomweyo imakutidwa ndi kesi yoteteza kuwala thioctic acid amamva kuwala. Kulowetsako kumapangidwa kuchokera mwachindunji. Mulingo wa oyang'anira ndi pafupifupi 1.7 ml / min.

Njira yothetsera kulowetsedwa imakonzedwa kuchokera kuzowonjezera: zomwe zili 1 ampoule (zomwe zimakhala ndi 600 mg ya thioctic acid) zimasakanizidwa ndi 50-250 ml ya yankho la 0.9% sodium chloride. Mukatha kukonzekera, botolo lomwe limayambitsa kulowetsedwa limakutidwa ndi vuto loteteza. Njira yothetsera kulowetsedwa iyenera kuperekedwa mofulumira mukakonzekera. Nthawi yayikulu yosungirako yothetsera kulowetsedwa si zoposa maola 6

Mapeto a Thiogamma