Ndemanga za insulin glulisin, kuwunika kwa mankhwala, malangizo

Glulin insulin ndi mankhwala osokoneza bongo a hypoglycemic omwe amagwiritsidwa ntchito pochita zachipatala pochiza matenda osapatsa insulin omwe amadalira odwala komanso omwe samadalira insulin. M'nkhaniyi, tiona insulin glulisin - dzina la malonda.

Yang'anani! Mu gulu la anatomical-achire-kemikali (ATX), mankhwala akuwonetsedwa ndi code A10AB06. Dongosolo losavomerezeka padziko lonse (dzina lachi Latin): Insulin glulisine.

Kapangidwe kake ka insulin glulisin (C 258H384N64O78S6, M r = 5823 g / mol) pafupifupi kali kofanana ndi kaumunthu kupatulapo katsitsumzukwa kwa katsitsumzukwa. Kusintha kwa katsitsumzukwa pamalo a B3, omwe amapezeka mu insulin ya anthu, komanso lysine pamalo a B29 omwe ali ndi glutamic acid, kumabweretsa kuyamwa kwa magazi mwachangu m'magazi.

Kutulutsa Fomu

Wodziwika bwino dzina la mankhwala ndi Apidra. Sanofi-Aventis Kuchita zinthu mwachangu kudavomerezedwa mu Seputembara 2004 ndi European Commission.

Apidra ndiye insulin yoyamba kukhala ndi zinc monga chosakhazikika (mlatho wamchere pakati pa glutamate B29 ndi glycine A1). Mankhwalawa amapezeka ndi ukadaulo wa maumboni a DNA kuchokera ku Escherichia coli.

Pharmacodynamics ndi pharmacokinetics

Apidra ali ndi matenda a hypoglycemic komanso antidiabetes. Mankhwala amayamba msanga komanso amafupikitsa nthawi yokhala ndi kayendedwe ka subcutaneous poyerekeza ndi mahomoni wamba. Hypoglycemic zotsatira za insulin glulisin amayamba 10-20 mphindi pambuyo makonzedwe ndipo kumatenga pafupifupi 4 maola.

Insulin imapangidwa mu kapamba - maselo a beta a islets a Langerhans. Pakupanga kwa mahomoni, proinsulin imagawidwa kukhala molekyulu ya insulin ndi zomwe zimatchedwa C-peptide. Zotsatira zake, C peptide ikhoza kugwiritsidwa ntchito kuti idziwe ngati thupi likupitilizabe kupanga insulin yake.

M'maselo a alpha a kapamba, thupi limapanganso shuga wa m'magulu. Imagwira pafupifupi chosiyana ndi insulin: pomwe insulin imachepetsa glycemia, glucagon imalimbikitsa kupanga ndikupereka shuga m'magazi ndikuwonjezera.

Matumbo ang'onoang'ono amaswa chakudya cham'madzi mu monosaccharides. Ma mamolekyulu a shugawa amadutsa khoma lamatumbo kulowa m'magazi, kenako amawagawa kuchokera m'magawo osiyanasiyana m'thupi momwe amagwiritsidwira ntchito kupanga mphamvu.

Insulin ndi mahomoni omwe amasintha kuyamwa kwa glucose ndi maselo. Maselo amakhala ndi ma insulin ambiri. Chifukwa chake, glucose amatha kulowa kuchokera m'mitsempha yamagazi ndikulowa mu intracellular space. Ngati mankhwalawa amalephera, monga momwe zimakhalira ndi matenda a shuga a 2, shuga amadziunjikira m'magazi.

Hemayo amasamutsa shuga makamaka m'maselo a minofu, chiwindi, impso ndi adipose minofu, koma osati ku ubongo. Maselo aubongo amatha kutenga glucose popanda insulin. Thupi limakhalanso ndi glucose, lomwe limasungidwa ngati glycogen m'chiwindi makamaka m'misempha.

Kuphatikiza pa ntchito yofunikira iyi, timadzi timagwira ntchito zina mthupi. Hormayo imathandizira kwambiri kulakalaka kudya ndipo imalepheretsa kuwonongeka kwa minofu ya adipose (lipolysis). Ndikusowa kwathunthu kwa insulini, shuga akamalowa m'maselo, thupi limagwiritsa ntchito minofu ya adipose kuti ipange mphamvu.

Zizindikiro ndi contraindication

• Matenda a shuga a insulin komanso osadalira insulini.

Mankhwala amatsatiridwa chifukwa cha hypersensitivity komanso hypoglycemia. Chidziwitso chokwanira pakuchenjeza komanso kuchitirana nawo zitha kupezeka m'malangizo kapena kwa dokotala.

Mlingo ndi bongo

Malinga ndi malangizo ogwiritsira ntchito mankhwalawa, mankhwalawa amayenera kumwedwa mkati mwa mphindi 0-15 musanadye kapena atangodya. Mankhwalawa amapaka jekeseni wokhazikika m'mimba khoma, ntchafu kapena mkono wam'mwamba. Tsamba la jakisoni liyenera kusinthidwa pafupipafupi kuteteza zotsatira zoyipa za mdera lanu. Hormoni imathanso kutumikiridwa kudzera m'mitsempha pogwiritsa ntchito insulin pump komanso njira zina zapadera.

Mukapatsidwa mankhwala mosasamala, chisamaliro chikuyenera kuthandizidwa kuti zitsimikizidwe kuti zikuyenderana. Mwakutero, ingathenso kuthandizidwa mu intramuscularly, koma njira yoyendetsera iyi siyikulimbikitsidwa, chifukwa imatha kuwononga minofu. Mitundu itatu yoyendetsa imakhala ndi zosiyana. Zambiri zokhudzana ndi zovuta za insulin nthawi zonse zimakhazikitsidwa ndi kayendetsedwe ka subcutaneous. Mgwirizano makonzedwe nthawi zambiri kumabweretsa mathamangitsidwe amtundu wa 30-50%. Tikagulitsidwa m'malo owonongeka a minofu, mphamvuyo imatha kukhalapo.

Mitsempha, insulini iyenera kuperekedwa kokha mosamala kwambiri, kuyambira pomwe kuchitapo kanthu kumachitika. Shuga wamagazi amayamba kutsika mofulumira. Kutsika msanga, komanso kuchuluka kwambiri kwa shuga m'magazi, kumabweretsa kuwonongeka kwa maselo. Chifukwa chake, insulin imayendetsedwa kokha mwadzidzidzi komanso mwaling'ono.

Pofuna kupewa calcium-cholesterol yomwe imayikidwa m'mitsempha (pambuyo pake zovuta) pambuyo pa vuto lalikulu la hyperglycemia, sikulimbikitsidwa kuperekera mankhwala kudzera m'mitsempha. Ubwino wopanga insulin ndikuti mphamvu zake zimatha pafupifupi mphindi 50.

Kuopsa kwa hypoglycemia chifukwa cha kuchitapo kanthu kwa mankhwalawa kuyenera kupewedwa ndikupereka shuga.

Intravenous insulin mankhwala angathe kuchitidwa ndi muyezo insulin syringes. Nthawi zina odwala amamva kukoma kwazitsulo atapereka mankhwala.

Kuchita

Mukamamwa zotsatirazi zogwira ntchito, zotsatira za mankhwala zimwonjezeka kwambiri:

• Monoamine oxidase zoletsa
• Beta blockers,
• Angiotensin otembenuza enzyme zoletsa,
• Mankhwala osokoneza bongo
• Hypocholesterol mankhwala
• Psychotropic mankhwala - fluoxetine, tetrahydrocannabinol, ethanol,
• Ma Opioid Analgesics - Morphine,
• Penoxifylline
• Mankhwala othandizira a Sulfonamide
• Acetylsalicylic acid.

Ndikulimbikitsidwa kuti mukafunse ndi dokotala wanu za zochitika zina. Hypothetically, mankhwalawa amatha kuyanjana ndi chinthu chilichonse chomwe chimakhudza glycemia wodwala. Chifukwa chake, tifunika kufunsa dokotala musanagwiritse ntchito mankhwala aliwonse kuti mupewe mavuto.

Analogs ndi choloweza mmalo mwa mankhwalawa:

Maganizo a adotolo komanso odwala.

Mankhwala ndi a ultrashort oyenera kwa odwala matenda ashuga omwe ali ndi vuto lalikulu la postprandial hyperglycemia. Musanagwiritse ntchito, muyenera kusintha mlingo ndi dokotala kuti mupewe hypoglycemia.

Mikhail Alexandrovich, katswiri wa matenda ashuga

Ndimalowetsa chakudya cham'mawa nthawi zonse. Samva zoyipa zilizonse, kupatula kugwedeza pang'ono. Monga glucometer amawonetsera, glycemia imakhalabe yokhazikika pambuyo pa chakudya cham'mawa chopatsa thanzi. Ndipitiliza kuyambitsa.

Ultrashort insulin Glulizin - mawonekedwe ndi mawonekedwe a ntchito

Mtundu wa matenda ashupi amtundu woyamba, wodwala amatha kugwiritsa ntchito insulin yofulumira (yofulumira), yochepa, yapakati, yayitali komanso yosakaniza.

Yemwe angafotokozere za mtundu wokwanira wa mankhwala zimadalira munthu payekha. Pakakhala insulin yayifupi kwambiri, Glulisin amagwiritsidwa ntchito.

Insulin Glulisine ndi analogue ya insulin ya anthu, yomwe imafanana ndi mahomoni awa. Koma mwachilengedwe, imagwira ntchito mwachangu komanso imakhala yochepa.

Glulisin imaperekedwa ngati yankho la subcutaneous makonzedwe. Chimawoneka ngati madzi owonekera popanda zosayera.

Mayina amalonda a mankhwala okhala ndi iye: Apidra, Epidera, Apidra Solostar. Cholinga chachikulu cha mankhwalawa ndikukhazikitsa kagayidwe ka glucose.

Malinga ndi zomwe zikuchitika, zabwino ndi zovuta izi:

• Amachita mofulumira kuposa mahomoni amunthu (+),
• imakwaniritsa kufunika kwa chakudya mu insulin (+),
• kuthekera kosagwirizana ndi mphamvu ya mankhwalawa m'magazi a shuga (-),
• mphamvu yayikulu - gawo limachepetsa shuga kuposa ma insulin ena (+).

Pambuyo pa subcutaneous makonzedwe, pali kuchepa kwa glucose chifukwa cha kukoka kwake kwa kugwiritsidwa ntchito kwake mu minofu komanso kupsinjika kwa njirazi mu chiwindi. Kuchitikaku kumayambira mphindi 10 jekeseni.

Ndi kukhazikitsidwa kwa Glulisin ndi insulini yokhazikika mphindi zochepa asanadye, wakale amakhala ndi mphamvu yolamulira pakatha kudya. The bioavailability wa chinthu pafupifupi 70%.

Kulumikizana ndi mapuloteni a plasma ndikosatheka. Amachotseredwa mwachangu kuposa momwe amachitira majekiseni amtundu wa anthu. Hafu ya moyo wa mphindi 13.5.

Mankhwalawa amaperekedwa nthawi yomweyo musanadye (kwa mphindi 10-15) kapena mukangomaliza kudya, poganizira mankhwala omwe mumalandira ndi ma insulin ena (munthawi ya chochita kapena kuyambira). Njira zoyendetsera: mwapang'onopang'ono ntchafu, phewa. Popewa kuvulala, tsamba la jakisoni limatsitsidwa. Mankhwalawa amaperekedwa m'malo osiyanasiyana, koma m'malo omwewo.

Glulisin amaphatikizidwa ndi ma insulin ndi othandizira otsatirawa:

• ndi analog ya basal hormone,
• ndi pafupifupi
• ndi lalitali
• Mankhwala okhala ndi hypoglycemic.

Mphamvu ya glycemia ndi kuwonjezera kwa insulin Glulizin kuchiritsa ndi basal insulin

Ngati njira yothetsera vutoli ikuyenera kuperekedwa pogwiritsa ntchito zolembera, ma jakisoni amachitidwa mogwirizana ndi malangizo a limangiroli. Mlingo wa mankhwalawa umasankhidwa payekha, poganizira momwe wodwalayo alili komanso kuchuluka kwa chiphuphu.

Musanagwiritse ntchito Glulizin, yodzazidwa mu cartridge, kuyendera kumachitika - njira yamatope yokhala ndi inclusions sioyenera kugwiritsidwa ntchito.

Malangizo a kanema ogwiritsa ntchito cholembera:

Mankhwala amalembedwa motere:

Contraindging poika mankhwala ali motere:

• achina,
• Hypersensitivity to glulisin,
• Hypersensitivity pamavuto othandizira a mankhwalawo.

Munthawi ya mankhwala ndi mankhwala, zimachitika zovuta.

Pafupipafupi zochitika zolakwika pamanambala, pomwe 4 ndizofala kwambiri, 3 nthawi zambiri, 2 ndizosowa, 1 ndiyosowa kwambiri:

Pa bongo wambiri, hypoglycemia ya zovuta zosiyanasiyana imawonedwa. Itha kuchitika nthawi yomweyo kapena kukula pang'onopang'ono.

Kutengera mphamvu ya insulin mankhwala, nthawi yayitali komanso kuuma kwa matendawa, zizindikiro za hypoglycemia zitha kusokonekera kwambiri. Wodwala ayenera kulingalira izi kuti ateteze vutolo munthawi yake. Kuti muchite izi, muyenera kukhala ndi shuga (maswiti, chokoleti, ma cubes opanda shuga) nanu.

Ndi hypoglycemia yolimbitsa komanso yolimbitsa, zinthu zomwe zimakhala ndi shuga zimatengedwa. Woopsa, komanso limodzi ndi kuwonongeka kwa chikumbumtima, jakisoni adzafunika.

Mpumulo wa hypoglycemia umachitika mothandizidwa ndi glucagon (s / c kapena i / m), yankho la glucose (i / v). Pakupita masiku atatu, mkhalidwe wa wodwalayo umayang'aniridwa. Popewa kukula kwa hypoglycemia wobwerezabwereza, ndikofunikira kumwa chakudya pakapita kanthawi.

Kumayambiriro kwa mankhwala omwe ali ndi insulin ya ultrashort, kuyanjana kwake ndi mankhwala ena kumazingidwa.

Mankhwala ambiri amatha kuthana ndi kagayidwe ka glucose, kukulitsa kapena kuchepetsa zotsatira za insulin. Asanalandire chithandizo, wodwala ayenera kudziwitsidwa kuti apewe mavuto.

Mankhwala otsatirawa amalimbikitsa zotsatira za Glulisin: Fluoxetine, othandizira a hypoglycemic mapiritsi, makamaka, sulfonylureas, sulfonamides, salicylates, fibrate, ACE inhibitors, Disopyramide, MAO inhibitors, Pentoxifylline, Propoxifen.

Mankhwala otsatirawa amachepetsa mphamvu ya mankhwala a insulin: atypical antipsychotic, sympathomimetics, kulera kwapakamwa, mahomoni a chithokomiro, glucagon, mahomoni achigololo achikazi, thiodiphenylamine, somatropin, diuretics, glucocorticosteroid mankhwala (GCS), proteinase inhibitors,

Pentamidine, beta-blockers, ndi clonidine amatumizidwa ku mankhwala omwe mosasamala angakhudze mphamvu ya chiwonetsero cha Glulisin ndi mulingo wa shuga (kuchepa ndi kuwonjezeka). Mowa ulinso ndi zomwezo.

Kusamala kwakukulu kumawonedwa popereka pioglitazone kwa odwala omwe ali ndi mtima matenda a mtima. Akaphatikizidwa, milandu ya kukhazikika kwa mtima idanenedwa mwa odwala omwe ali ndi chiyembekezo cha matendawa.

Ngati chithandizo cha pioglitazone sichitha kutha, ndikofunikira kuyang'anira momwe zinthu ziliri. Ngati zizindikiro zilizonse zamtima (kuwonda, kutupa) ziwoneka, kugwiritsa ntchito mankhwalawa kumachotsedwa.

Wodwalayo ayenera kuganizira izi:

1. Ndi vuto la impso kapena kuphwanya ntchito yawo, kufunika kwa insulini kungachepe.
2. Ndi kukanika kwa chiwindi, kufunikira kumacheperanso.
3. Chifukwa cha kusowa kwa chidziwitso, mankhwalawa saikidwa kwa ana osakwana zaka 6.
4. Gwiritsani ntchito mosamala amayi apakati omwe ali ndi kuyang'anira pafupipafupi pazisonyezo.
5. Pa mkaka wa m`mawere, kusintha kwa mlingo ndi zakudya zimafunika.
6. Mukasintha kupita ku Glulisin kuchokera ku mahomoni ena chifukwa cha hypersensitivity, kuyesedwa kwa ziwengo kuyenera kuchitidwa kupatula kusagwirizana.

Kusintha kwa Mlingo kumachitika pa kusintha kwa mtundu wina wa mahomoni obayira. Mukasamutsa kuchokera ku insulin ya nyama kupita ku Glulisin, mlingo umakonda kusintha m'njira yochepetsera chomaliza. Kufunika kwa mankhwalawa kumasintha ndikusokonezeka kwam'maganizo / m'maganizo, munthawi ya matenda opatsirana.

Chiwembucho chimayendetsedwa mothandizidwa ndi mankhwala a mapiritsi a hypoglycemic. Ngati mutasintha gawo lililonse la pulogalamuyi, mungafunike kusintha mlingo wa Glulisin.

Nthawi zambiri za hyperglycemia / hypoglycemia, zotsatirazi zomwe zimadalira mlingo zimafotokozedwa kaye musanayambe kuchuluka kwa mankhwalawa:

• njira ndi malo operekera mankhwala,
• Kutsatira njira zamankhwala,
• kumwa mankhwala ena limodzi
• psycho-state state.

Alumali moyo mutatsegula - mwezi

Kusungirako - kuyambira pa +2 mpaka + 8ºC. Osati kuzizira!

Kupumula ndikumvera mankhwala.

Glulisin ndiwofanana ndi insulin ya anthu:

Glulisin ndi mahashoni a ultrashort wokhazikitsa kagayidwe ka glucose. Amayikidwa limodzi ndi ma insulin ena, poganizira masankho omwe adasankhidwa. Musanagwiritse ntchito, ndikofunikira kuphunzira malangizo ndi kulumikizana ndi mankhwala ena.

Mankhwala insulin glulisin: malangizo ntchito

Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin. Zimayambitsidwa m'thupi kokha mothandizidwa ndi jakisoni. Imayendetsa moyenera Zizindikiro za glycemic.

Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin.

Kusunga kwa ATX - A10AV06.

Ipezeka pansi pa mayina amalonda Apidra ndi Apidra SoloStar.

Mankhwalawa ndi njira yofananiranso yamankhwala a insulin.Mphamvu yakuchitapo kanthu ndi yofanana ndi imelo yomwe imapangidwa ndi kapamba wabwino. Glulisin amachita zinthu mwachangu komanso amakhala ndi mphamvu yayitali.

Pambuyo makonzedwe kwa thupi (subcutaneously), timadzi timayamba kukhazikitsa kagayidwe kazachilengedwe.

Thupi limachepetsa kuchuluka kwa shuga m'magazi, limalimbikitsa mayamwidwe ake ndi minyewa, makamaka minofu yamatumbo ndi minofu ya adipose. Amalepheretsa mapangidwe a glucose mu zimakhala za chiwindi. Kuchulukitsa mapuloteni.

Kafukufuku wachipatala akuwonetsa kuti glulisin, womwe umaperekedwa kwa mphindi ziwiri asanadye, umaperekanso kuchuluka kwa shuga m'magazi momwe munthu amasungunulira insulin, yoyendetsedwa ndi theka la ola asanadye.

Zochita za insulin sizisintha mwa anthu amitundu yosiyanasiyana.

Pambuyo subcutaneous makonzedwe a mankhwala, pazenera ambiri mu magazi amafika pambuyo mphindi 55. Nthawi yayitali yakukhala mankhwala omwe ali m'magazi ndi mphindi 161. Ndi subcutaneous makonzedwe a mankhwalawa m'dera lakhomopo khoma kapena phewa, mayamwidwe mwachangu kuposa kukhazikitsa kwa mankhwala mu ntchafu. Bioavailability pafupifupi 70%. Kuchotsa theka-moyo pafupifupi mphindi 18.

Pambuyo pakuyendetsa pang'onopang'ono, glulisin imachotsedwako mwachangu kuposa insulin yamunthu yomweyo. Ndi kuwonongeka kwa impso, kuthamanga kwa kuyambira kwa zomwe zimafunikira kumakhazikika. Zambiri pazakusintha kwamatenda a insulin mwa okalamba sizinaphunzitsidwe mokwanira.

Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.

Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.

Mankhwala ndi contraindicated vuto la hypoglycemia ndi hypersensitivity kwa Apidra.

Imaperekedwa pang'onopang'ono 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni. Simungathe kusakaniza mitundu ingapo ya insulini mu syringe yomweyo, ngakhale kuti wodwalayo akhoza kupatsidwa ma insulin osiyanasiyana. Kubwezeretsanso yankho lisanayambike makonzedwe ake.

Musanagwiritse ntchito, muyenera kuyang'ana botolo. Ndikothekanso kusungitsa yankho mu syringe pokhapokha ngati yankho likuwonekera komanso lilibe tinthu tambiri.

Khola lomweli liyenera kugwiritsidwa ntchito ndi wodwala m'modzi. Ngati yawonongeka, saloledwa kuigwiritsa ntchito. Musanagwiritse ntchito cholembera, fufuzani mosamala cartridge. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka komanso lopanda zosayera. Cholembera chopanda kanthu ziyenera kutayidwa ngati zinyalala za m'nyumba.

Mankhwalawa kutumikiridwa subcutaneously 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni.

Pambuyo pochotsa kapu, tikulimbikitsidwa kuti mulembe mayendedwe ndi yankho. Kenako ikani singano mosamala ndi cholembera. Mu chipangizo chatsopano, chizindikiro cha mankhwalawa chimawonetsa "8". Ntchito zina, ziyenera kuyikidwa pambali pa chizindikiro "2". Kanikizani batani la dispenser njira yonse.

Kugwira chiwongoladzanja, chotsani thovu lamkati podina. Ngati zonse zachitika molondola, dontho laling'ono la insulini limawonekera pamphumi ya singano. Chipangizocho chimakuthandizani kuti muyike mlingo kuchokera pa 2 mpaka 40 mayunitsi. Izi zitha kuchitika ndikutembenuza chotumiza. Kulipiritsa, batani la dispenser likulimbikitsidwa kuti lizikokedwa njira yonse.

Ikani singano m'matumba a subcutaneous. Kenako dinani batani njira yonse. Asanachotsere singano, iyenera kuchitidwa kwa masekondi 10. Pambuyo pa jakisoni, chotsani ndikuchotsa singano. Mulingo wake ukuonetsa kuchuluka kwa insulini yomwe imatsala mu syringe.

Ngati cholembera sichingagwire ntchito molondola, ndiye kuti yankho limatha kutengedwa kuchokera ku cartridge kupita ku syringe.

Zotsatira zoyipa kwambiri za insulin ndi hypoglycemia. Itha kuchitika chifukwa chogwiritsa ntchito mlingo waukulu wa mankhwalawa. Zizindikiro zakuchepa kwa shuga m'magazi zimayamba pang'onopang'ono:

• thukuta lozizira
• khungu komanso kuzirala kwa khungu,
• kutopa kwambiri
• chisangalalo
• zosokoneza zowoneka
• kunjenjemera
• nkhawa zazikulu
• chisokonezo, zovuta kuyang'ana,
• kumva kupweteka m'mutu,
• palpitations.

Hypoglycemia ikhoza kuchuluka. Uku ndikuwopseza moyo, chifukwa kumayambitsa kusokonezeka kwa ubongo, ndipo m'malo ovuta kwambiri - imfa.

Pa malo a jakisoni, kuyabwa ndi kutupa kumachitika. Kuchita koteroko kwa thupi kumakhala kwakanthawi, ndipo simuyenera kumwa mankhwala kuti muchotse. Mwina chitukuko cha lipodystrophy mwa akazi pamalo opangira jakisoni. Izi zimachitika ngati zalembedwa pamalo amodzi. Kuti izi zisachitike, tsamba la jakisalo liyenera kusinthidwa.

Ndizachilendo kwambiri kuti mankhwala amatha kuyambitsa ziwopsezo.

Ndi hypoglycemia, ndizoletsedwa kuyendetsa galimoto kapena kugwiritsa ntchito njira zovuta.

Kusamutsa wodwala ku mtundu watsopano wa insulin kumachitika kokha moyang'aniridwa ndi achipatala. Nthawi zina, chithandizo cha hypoglycemic chingafunikire. Mukamasintha zolimbitsa thupi, muyenera kusintha mlingo wake.

Mankhwalawa amatha kugwiritsidwa ntchito mukalamba. Mankhwala osokoneza bongo safunikira.

Insulin yamtunduwu imatha kuperekedwa kwa ana azaka zopitilira zisanu ndi chimodzi.

Pali umboni wochepa wokhudza kugwiritsa ntchito mankhwalawa panthawi ya bere komanso poyamwitsa. Kafukufuku wazinyama wa mankhwalawa sanawonetse zotsatira zam'mimba.

Popereka mankhwala awa kwa amayi apakati, muyenera kusamala kwambiri. Ndikofunikira kuyeza shuga m'magazi.

Odwala omwe ali ndi matenda osokoneza bongo amafunika kuwunika kuchuluka kwa shuga m'magazi. Pa trimester yoyamba, zofunika za insulin zimatha kuchepera pang'ono. Kaya insulin idutsa mkaka wa m'mawere sichikudziwika.

Osasintha kuchuluka kwa mankhwalawa omwe amaperekedwa ndi mankhwalawo othandizira kuwonongeka kwa impso.

Maphunziro azachipatala kwa odwala omwe ali ndi vuto la chiwindi ntchito sanachitepo.

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo digiri yake imatha kukhala yosiyana - kuyambira yofatsa mpaka yamphamvu.

Magawo a hypoglycemia ofatsa amaletsedwa kugwiritsa ntchito shuga kapena shuga. Ndikulimbikitsidwa kuti odwala nthawi zonse azikhala ndi maswiti, makeke, msuzi wokoma, kapena zidutswa za shuga woyengedwa nawo limodzi.

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo digiri yake imatha kukhala yosiyana - kuyambira yofatsa mpaka yamphamvu.

Ndi kuchuluka kwambiri kwa hypoglycemia, munthu amasiya kuzindikira. Glucagon kapena dextrose amaperekedwa ngati thandizo loyamba. Ngati palibe chochitika pakayendetsedwe ka glucagon, ndiye kuti jakisoni yemweyo imabwerezedwa. Pambuyo podzikanso, muyenera kupatsa wodwalayo tiyi wokoma.

Mankhwala ena amatha kuthana ndi shuga kagayidwe. Izi zimafunikira kusintha kwa insulin. Mankhwala otsatirawa amalimbikitsa hypoglycemic zotsatira za Apidra:

• othandizira otsegula pakamwa,
• ACE zoletsa
• Ma Disopyramides,
• mafupa
• Fluoxetine,
• monoamine oxidase zoletsa zinthu
• Pentoxifylline
• Propoxyphene,
• salicylic acid ndi zotumphukira zake,
• sulfonamides.

Mankhwala oterewa amachepetsa ntchito ya insulin:

• GKS,
• Danazole
• Diazoxide
• okodzetsa
• Isoniazid,
• Phenothiazine zotumphukira
• Kukula kwamafuta,
• chithokomiro cha chithokomiro,
• mahomoni ogonana achikazi omwe amapezeka mu mankhwala oletsa kubereka,
• zinthu zomwe zimalepheretsa mapuloteni.

Beta-blockers, clonidine hydrochloride, kukonzekera kwa lifiyamu kungakulitse, kapena,, kufooketsa ntchito ya insulin. Kugwiritsidwa ntchito kwa pentamidine kumayambitsa hypoglycemia, kenako kuwonjezeka kwakuchuluka kwa glucose wamagazi.

Insulin sikuyenera kusakanikirana ndi mitundu ina ya mahomoni awa mu syringe yomweyo. Zomwezo zimagwiranso ntchito ndi mapampu a kulowetsedwa.

Kumwa mowa kumatha kuyambitsa hypoglycemia.

Ma fanizo a Glulisin ndi awa:

• Apidra
• Novorapid Flekspen,
• Epidera
• insulin isophane.

Apidra amapezeka pamankhwala. Anthu odwala matenda ashuga amapeza mankhwalawo kwaulere.

Mtengo wa cholembera sichikhala pafupifupi ma ruble 2,000.

Makatoni ndi mbale osatsegulidwa ziyenera kusungidwa mufiriji yokha. Kuzizira kwa insulin sikuloledwa. Mbale ndi ma cartridge otseguka amasungidwa pa kutentha osaposa + 25ºC.

Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu inayi, pambuyo pake uyenera kutayidwa.

Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu inayi, pambuyo pake uyenera kutayidwa.

Amapangidwa ku bizinesi Sanofi-Aventis Deutschland GmbH, Germany.

Ivan, wazaka 50, wodwala matenda a kubadwa kwa matenda, ku Moscow: “Mothandizidwa ndi Apidra, ndizotheka kuyendetsa zizindikiro za glycemia mwa odwala matenda ashuga a mtundu woyamba. Ndikupangira kuperekera insulin musanadye. Imathimitsa mayendedwe abwino a zizindikilo za shuga. ”

Svetlana, wazaka 49, wasayansi ya matenda ashuga, Izhevsk: "Glulisin ndi imodzi mwazinthu zabwino kwambiri. Odwala amalekerera bwino, koma malinga ndi kuchuluka ndi ma regimens. Hypoglycemia ndiosowa kwambiri. "

Andrei, wazaka 45, ku St. Petersburg: "Glulizin siyambitsa shuga kwambiri, zomwe ndi zofunika kwa ine monga wodwala matenda ashuga" wodziwa zambiri ". Malo pambuyo pobayidwa sikupweteka kapena kutupa. Mukatha kudya, kuwerenga kwa glucose ndikwabwinobwino. ”

Olga, wazaka 50, Tula: "Ma insulini akale ankandipangitsa kuti ndizizindikira, ndipo malowo anali opweteka. Glulisin samayambitsa zizindikiro zotere. Ndikosavuta kugwiritsa ntchito cholembera ndipo, koposa zonse, ndizothandiza. ”

Lidiya, wazaka 58, Rostov-on-Don: “Chifukwa cha Glulizin, ndimatha kudya shuga wambiri ndikatha kudya. Ndimatsata zakudya mosamala ndikuwerengera mlingo wa mankhwalawo. Palibe zochitika za hypoglycemia. ”

Insulin Glulisine: malangizo, ndemanga, analogi

Matenda a shuga ndi matenda oopsa omwe amatha kudalira insulini (mtundu 1) kapena osadalira insulini (mtundu 2). Potsirizira pake, matendawa amathandizidwa bwino mothandizidwa ndi othandizira a hypoglycemic komanso zakudya zapadera. Koma ndi mtundu woyamba wa matenda komanso matenda amtundu 2 atayamba, chithandizo cha insulin sichingagawidwe nawo.

Nthawi zambiri, odwala omwe ali ndi kuchuluka kwa shuga m'magazi amapatsidwa insulin Glulizin. Ili ndi yankho loyera la jakisoni, chinthu chachikulu chomwe ndi analogue ya sungunuka wa insulin yaumunthu, chopangidwa pogwiritsa ntchito genetic engineering.

Mankhwala ali ndi kufupikitsa komwe kumapangitsa kutsika kwa shuga m'magazi. Apidra SoloStar ndi Apidra ndi omwe ali ndi njira, zomwe zimaphatikizira insulini Glulisin.

Njira yothetsera vutoli imakhala ndi kufupikitsa kwakanthawi. Kuphatikiza apo, imayendetsa njira ya kuyamwa kwa glucose ndi zotumphukira zamafuta (mafuta, minofu yamafupa), ndikuletsa ntchito yopanga shuga m'magazi.

Mankhwala amathandizanso kuphatikiza mapuloteni, amalepheretsa mapuloteni ndi lipolysis mu adipocytes. Pambuyo pothandizidwa ndi subcutaneous, kutsika kwa shuga kumachitika pambuyo pa mphindi 10-20.

Pankhani ya kayendetsedwe ka iv, mphamvu ya hypoglycemic ikufanana ndi zochita za insulin ya anthu. Chifukwa chake, pogwira ntchito, 1 IU ya insulini Glulisin ndi 1 IU ya insulle ya anthu sungunuka.

Poyerekeza ndi insulin yaumunthu, Glulisin amalowetsedwa mwachangu kwambiri. Izi zimachitika chifukwa cholowa m'malo mwa asparagine amino acid (3B) ndi lysine, komanso lysine (malo 29B) ndi glutamic acid.

Mafuta pambuyo pa sc makonzedwe:

1. pa ntchafu - sing'anga
2. khoma pamimba - mwachangu,
3. mapewa - apakatikati.

Mtheradi bioavailability ndi 70%. Mukamayambitsidwa m'malo osiyanasiyana, ndizofanana ndipo zimakhala ndi kusiyana kochepa pakati pa odwala (kusiyanasiyana kwa 11%).

Mukapatsidwa mankhwala osokoneza bongo ndi mtundu woyamba wa shuga, 0,15 U / kg TCmax ndi mphindi 55, ndipo kg Cmax ndi 80.7-83.3 μU / ml. Mu mtundu wachiwiri wa matenda, pambuyo poti mankhwalawa amapezeka pa 0,2 PESCES / kg, Cmax ndi 91 mcU / ml.

Pakufalikira kwazinthu, nthawi yokwanira yowonekera ndi 98 min. Ndi on / kumayambiriro, voliyumu yogawa ndi 13 malita, T1 / 2 - 13 Mphindi. AUC - 641 mg xh / dl.

Ma pharmacokinetics mu odwala matenda ashuga osakwana zaka 16 okhala ndi mtundu woyamba wa matenda ali ofanana ndi akulu. Ndi sc management T1 / 2 ndi kuyambira 37 mpaka 75 mphindi.

Insulin Glulizin imayang'aniridwa pang'onopang'ono, mlingo umasankhidwa payekha kwa wodwala aliyense. Kuvulala kumachitika mu mphindi 0 mpaka 15. musanadye kapena mutamaliza kudya.

Glulisin amagwiritsidwa ntchito pochiritsa regimens, kuphatikizapo kugwiritsa ntchito insulin yapakatikati kapena yayitali, kapena mawonekedwe awo. Komanso, mankhwalawa amatha kugwiritsidwa ntchito limodzi ndi mankhwala omwe ali ndi vuto la hypoglycemic, omwe amagwiritsidwa ntchito pakamwa.

Njira yothetsera vutoli imayendetsedwa ngati jakisoni wofinya kapena kulowetsedwa pogwiritsa ntchito pampu ya insulin. Jakisoni amachitika m'mbali mwa phewa, ntchafu, khomo lam'mimba lakunja. Ndipo kuyambitsa ndalama kudzera kulowetsedwa kosalekeza kumachitika mu peritoneum.

Ma zone a jakisoni ndi ma infusions ayenera kusinthidwa nthawi iliyonse. Kuthamanga kwa mayamwidwe, kuyamba ndi kutalika kwa zotsatirazi kumatsimikiziridwa ndi zinthu zingapo (zolimbitsa thupi, malo opangira jekeseni). Ponyowa mwachangu, mankhwalawa amayenera kuponyedwa m'malo oyambira kukhoma pamimba.

Ndikofunika kusamala kuti insulin Glulisin isalowe m'mitsempha yamagazi. Chifukwa chake, aliyense wodwala matenda ashuga ayenera kukhala wodalirika popereka insulin. Pambuyo pa jekeseni, tsamba la jekeseni limaletsedwa kutikita minofu.

Glulisin amaloledwa kuphatikizidwa ndi Isofan (insulin yaumunthu), koma Glulisin ayenera kukokedwa mu syringe yoyamba. Kuwongolera kwa SC kuyenera kuchitika pokhapokha posakaniza ndalama. Pankhaniyi, osakaniza a Isofan ndi Glulisin amaletsedwa kutumizidwa kudzera m'mitsempha.

Ngati insulin Glulisin imayendetsedwa pogwiritsa ntchito pampu, ndiye kuti kitacho chimayenera kusinthidwa maola 4 aliwonse, kutsatira malamulo a antiseptic. Ndi kulowetsedwa kwa kayendetsedwe ka mankhwala, mankhwalawa sayenera kukhala osakanikirana ndi njira zina kapena ma insulin.

Pankhani yogwiritsa ntchito pampu mosayenera kapena kuphwanya ntchito yake, matenda ashuga a ketoacidosis, hyperglycemia kapena ketosis angayambike. Popewa kupezeka kwa zinthu ngati izi, musanachite njirayi, muyenera kuphunzira malamulo mosamala ndi kuwerengera mosamala.

Musanagwiritse ntchito yankho, muyenera kuyang'ana kusinthasintha kwake, utoto wake ndikuwonetsetsa kuti mulibe tinthu tachilendo. Ngati mankhwalawo ndi amtambo, achikuda kapena osayera, ndiye kuti nzoletsedwa kugwiritsa ntchito.

Insulin Glulizin sagwiritsidwa ntchito pochiza ana osaposa zaka 6, ndi hypoglycemia ndi hypersensitivity ku zigawo zake. Zotsatira zoyipa kwambiri ndizo hypoglycemia. Mawonekedwe amtundu wakhungu ndi kusokonezeka kwa metabolic ndizothekanso.

Nthawi zina zimakhala ndi vuto la neuropsychiatric monga kugona, kutopa, kufooka, kuluma, ndi mseru. Mutu, kusowa kwa chidwi, kusokonezeka kwa malingaliro ndi kusokonezeka kowonekera kumawonekeranso.

Nthawi zambiri, musanafike vuto la neuropsychiatric, zizindikiro za adrenergic anti-regulation zimachitika. Uku ndi njala, kusakwiya, tachycardia, chisangalalo chamanjenje, thukuta lozizira, nkhawa, kufinya khungu ndi kunjenjemera.

Ndizofunikira kudziwa kuti kuukira kwamphamvu kwa hypoglycemia, komwe kumachitika mobwerezabwereza, kumabweretsa kuwonongeka kwa NS. Komanso, nthawi zina, izi zitha kubweretsa imfa.

Kuphatikiza pa kutsika kwakuthwa kwa shuga, zovuta zakomweko zingachitike m'malo omwe jekeseni adapangidwira. Izi zimaphatikizapo hyperemia, kutupa ndi kuyabwa, nthawi zambiri mawonetseredwe awa amazimiririka pawokha pakulandila chithandizo. Nthawi zina, chifukwa chosagwirizana ndi kusintha kwa malo a insulin, wodwala matenda ashuga amatha kukhala ndi lipodystrophy.

Zizindikiro zokhudzana ndi hypersensitivity ndizothekanso:

• kuyabwa
• urticaria
• matumbo a ziwongo,
• chifuwa cholimba
• kutsutsika.

Matendawa:

Ngati mankhwala osokoneza bongo, hypoglycemia yamphamvu zosiyanasiyana ikhoza kuchitika. Ndi kuchepa pang'ono kwa shuga m'magazi, wodwalayo ayenera kumwa zakumwa kapena zinthu zokhala ndi shuga.

Ndi vuto lalikulu kwambiri komanso kusazindikira, s / c kapena v / m amathandizidwa ndi Dextrose kapena Glucagon. Wodwala akayambanso kuzindikira, ayenera kudya zakudya zopatsa mphamvu, zomwe zingapewe kuyambiranso.

Kufotokozera za ntchito yogwira Insulin glulisin / Insulinum glulisinum.

Fomula C258H384N64O78S6, dzina lamakemikolo: palibe deta.
Gulu lamagulu: mahomoni ndi okana / ma insulin.
Machitidwe hypoglycemic.

Matenda a shuga, omwe amafunikira kugwiritsa ntchito insulin, mwa akulu ndi ana opitilira zaka zisanu ndi chimodzi.

Hypersensitivity insulin glulisin (kuphatikizapo hypersensitivity kwa zilizonse zothandiza za mankhwala), hypoglycemia, zaka mpaka 6.

Mimba, yoyamwitsa.

Mayina amalonda a mankhwala omwe ali ndi yogwira insulin glulisin

Apidra®
Apidra® SoloStar ®
Insulin glulisin

1. 
   Moroz B. T., Khromova E. A., Shustov S. B., et al. Tekinoloji yatsopano mu opaleshoni yopanga ma periodontics pamankhwala ovuta a odwala omwe ali ndi mtundu wa 2 matenda a shuga, Nauka Printer House - M., 2012. - 160 p.
2. 
   Bogdanova, O. Bukhu Lalikulu la odwala matenda ashuga. Chilichonse chomwe muyenera kudziwa chokhudza matenda ashuga / O. Bogdanova, N. Bashkirova. - M: AST, AST Moscow, Prime-Evroznak, 2008. - 352 p.
3. 
   Buku lophikira la Dietetic, Nyumba Yofalitsa Mabuku ya Sayansi Yonse pa UNIZDAT - M., 2015. - 366 c.

Ndiloleni ndidziwitse. Dzina langa ndi Elena. Ndakhala ndikugwira ntchito ya endocrinologist kwa zaka zoposa 10. Ndikukhulupirira kuti pakadali pano ndili katswiri pantchito yanga ndipo ndikufuna kuthandiza alendo onse omwe amapezeka pamalowo kuti athetse zovuta osati ntchito. Zinthu zonse za tsambalo amazisonkhanitsa ndikuzikonza mosamala kuti athe kufotokoza zambiri zofunikira. Musanagwiritse ntchito zomwe zikufotokozedwa pa webusaitiyi, kufunsana ndi akatswiri ndizofunikira nthawi zonse.

Njira yogwiritsira ntchito ndi contraindication

Glulisin ndi insulin yowonjezereka ya anthu, komabe, mphamvu yake ndiyofanana ndi ya insulin wamba ya anthu. Mankhwala amayamba kugwira ntchito mwachangu, koma ndi nthawi yochepa. Pakadutsa mphindi 10 mpaka 20 atabaya jekeseni, wodwalayo amva kupumula.

Kuphatikiza pa jekeseni wa subcutaneous, glulisin ya mankhwala imatha kuperekedwa ndi kulowetsedwa kosalekeza mu mafuta obisika ogwiritsira ntchito pampu ya insulin. Kubaya jekeseni kumachitika pang'onopang'ono kapena mukatha kudya.

Jakisoni wotsekemera amayenera kuchitidwa paphewa, m'chiuno kapena pamimba. Ngati tikulankhula za infusions mosalekeza, ndiye kuti amangochitika m'mimba.

Kugwiritsa ntchito mankhwalawa osavomerezeka pamilandu yotere:

• zaka za ana
• achina,
• kumva kwambiri.

Insulin Glulizin imagwira ntchito mu regimen ya mankhwala, yomwe imapereka insulin ya nthawi yayitali kapena yayitali. Mankhwalawa amagwiritsidwa ntchito limodzi ndi othandizira ena a hypoglycemic mu mawonekedwe a piritsi, ndikuwathandizidwanso pogwiritsa ntchito syringe ya insulin.

Kuwonetsedwa kwa zoyipa

Zotsatira zoyipa pambuyo pogwiritsira ntchito mankhwalawa zimatha kuchitika:

1. kumva kwambiri, mwachitsanzo, kutupa, kuyabwa ndi kufupika pamawebusayiti. Kusintha koteroko, monga lamulo, kumatha kwathunthu ndi chithandizo cha nthawi yayitali. Nthawi zina, chiwonetsero cha lipodystrophy (zovuta zamkhungu zomwe zimayambitsidwa ndi kuphwanya kosinthana kwa malo oyang'anira mankhwalawa) ndizotheka,
2. Thupi lawo siligwirizana (kufupika kwa mpweya, chifuwa, urticaria, kuyabwa, kuphipha kwa bronchi),
3. kutulutsa kofananira (mpaka kufikira anaphylactic).

Milandu yambiri

Pakadali pano, mankhwalawa alibe deta pazovuta za mankhwala osokoneza bongo, komabe, hypoglycemia yamphamvu zosiyanasiyana ndizoganiza.

Magawo a bongo wofatsa amatha kuyimitsidwa pogwiritsa ntchito shuga kapena zakudya zomwe zili ndi shuga. Pazifukwa izi, aliyense wodwala matenda ashuga ayenera kukhala ndi lokoma pang'ono naye.

Ndi kutayika kwambiri komanso komwe kumayenderana ndi chikumbumtima cha hypoglycemia, n`zotheka kuyimitsa njirayi kapena kulowererapo kwa glucagon ndi intravenous dextrose.

Pambuyo pozindikira, wodwalayo ayenera kudya zakudya zopatsa mphamvu. Izi zipangitsa kuti kukhale kotheka kukonzanso kwa hypoglycemia.

Zokhudza kugwiritsa ntchito mankhwalawa

Ngati Glulisin amagwiritsidwa ntchito limodzi ndi othandizira otsatirawa, ndiye kuti insulini ingalimbikitse zotsatira za hypoglycemic ndikuwonjezera mwayi wokhala ndi hypoglycemia:

• mankhwala akumwa a hypoglycemic,
• disopyramids
• ACE zoletsa
• mafupa
• Mao zoletsa
• salicylates,
• sulfonamides,
• propoxyphene.

Mukaphatikiza insulin ndi danazol, salbutamol, isoniazides, diazoxide, phenothiazine zotumphukira, somatropin, diuretics, epinephrine, terbutaline, proteinase inhibitors, antipsychotic mankhwala, Glulizin amachepetsa mphamvu ya hypoglycemic.

Kugwiritsa ntchito beta-blockers, mchere wa lithiamu, ethanol ndi clonidine kungafooketse mphamvu ya mankhwala a insulin Glulizin. Pentamidine imakwiyitsanso onse hypoglycemia ndi hyperglycemia chifukwa cha izo.

Kugwiritsa ntchito kwachifundo kwachifundo kumatha kumasuka kuwonetsa kwa adrenergic Reflex activation. Izi zimaphatikizapo guanethidine, clonidine.

Pokhapokha wodwala akapatsidwa mtundu wina wa insulin (kapena mankhwala kuchokera kwa wopanga watsopano), ayenera kuyang'aniridwa mosamalitsa. Izi ndizofunikira chifukwa chakufunika kusintha kwa mankhwalawa.

Mlingo wolakwika wa insulini Glulisin kapena kusiya kulandira chithandizo kumayambitsa kukula kwa hypoglycemia ndi matenda ashuga a ketoacidosis (mikhalidwe yomwe ingawononge moyo).

Nthawi ya chitukuko cha boma la hypoglycemic zimatengera kuthamanga kwa mankhwala omwe amagwiritsidwa ntchito ndipo angasinthe ndi kusintha kwa mankhwalawa.

Pali zochitika zina zomwe zimasintha kapena zimapangitsa ma harbinger a hypoglycemia omwe akuwoneka bwino, mwachitsanzo:

1. matenda a shuga
2. kulimbitsa chithandizo ndi insulin,
3. kutalika kwa matenda ashuga
4. kugwiritsa ntchito mankhwala ena
5. kusintha kwa wodwala kuchokera ku nyama kupita ku insulin yaumunthu.

Kusintha kwa muyezo wa insulin Glulisin ndikofunikira posintha njira yazakudya kapena kusintha zochita za wodwala. Kuchita masewera olimbitsa thupi mukangotha ​​kudya kumakhala chiopsezo cha hypoglycemia.

Ngati insulin yochita pang'ono ndiyenera kubayidwa, kuchepa kwakukulu kwa kuchuluka kwa shuga m'magazi kumawonedwa posachedwa kuposa kugwiritsa ntchito insulin yaumunthu.

Hypoglycemia yosakhudzidwa ndi zochitika za hyperglycemic zimatha kukhala zofunika kuti musataye chikumbumtima, kukula kwa chikomokere, komanso kufa!

Gwiritsani ntchito pa nthawi yoyembekezera

Amayi oyembekezera ayenera kugwiritsira ntchito insulin Glulisin moyang'aniridwa ndi dokotala ndikuwunika kuchuluka kwa shuga m'magazi.

Mukamayamwa, mankhwalawa samatha kulowa mkaka, motero amavomerezedwa kuti agwiritsidwe ntchito. Ngati mkaka wa m`mawere, ndikofunikira kusintha Mlingo wa kutumikiridwa. Kuphatikiza apo, kusintha kwa mlingo kungakhale koyenera pamaso pa zovuta zodwala komanso zovuta zokhudzana.

Pharmacological zotsatira ndi pharmacokinetics

Njira yothetsera vutoli imakhala ndi kufupikitsa kwakanthawi. Kuphatikiza apo, imayendetsa njira ya kuyamwa kwa glucose ndi zotumphukira zamafuta (mafuta, minofu yamafupa), ndikuletsa ntchito yopanga shuga m'magazi.

Mankhwala amathandizanso kuphatikiza mapuloteni, amalepheretsa mapuloteni ndi lipolysis mu adipocytes. Pambuyo pothandizidwa ndi subcutaneous, kutsika kwa shuga kumachitika pambuyo pa mphindi 10-20.

Pankhani ya kayendetsedwe ka iv, mphamvu ya hypoglycemic ikufanana ndi zochita za insulin ya anthu. Chifukwa chake, pogwira ntchito, 1 IU ya insulini Glulisin ndi 1 IU ya insulle ya anthu sungunuka.

Poyerekeza ndi insulin yaumunthu, Glulisin amalowetsedwa mwachangu kwambiri. Izi zimachitika chifukwa cholowa m'malo mwa asparagine amino acid (3B) ndi lysine, komanso lysine (malo 29B) ndi glutamic acid.

Mafuta pambuyo pa sc makonzedwe:

1. pa ntchafu - sing'anga
2. khoma pamimba - mwachangu,
3. mapewa - apakatikati.

Mtheradi bioavailability ndi 70%. Mukamayambitsidwa m'malo osiyanasiyana, ndizofanana ndipo zimakhala ndi kusiyana kochepa pakati pa odwala (kusiyanasiyana kwa 11%).

Mukapatsidwa mankhwala osokoneza bongo ndi mtundu woyamba wa shuga, 0,15 U / kg TCmax ndi mphindi 55, ndipo kg Cmax ndi 80.7-83.3 μU / ml. Mu mtundu wachiwiri wa matenda, pambuyo poti mankhwalawa amapezeka pa 0,2 PESCES / kg, Cmax ndi 91 mcU / ml.

Pakufalikira kwazinthu, nthawi yokwanira yowonekera ndi 98 min. Ndi on / kumayambiriro, voliyumu yogawa ndi 13 malita, T1 / 2 - 13 Mphindi. AUC - 641 mg xh / dl.

Ma pharmacokinetics mu odwala matenda ashuga osakwana zaka 16 okhala ndi mtundu woyamba wa matenda ali ofanana ndi akulu. Ndi sc management T1 / 2 ndi kuyambira 37 mpaka 75 mphindi.

Malangizo ogwiritsira ntchito mankhwalawa

Insulin Glulizin imayang'aniridwa pang'onopang'ono, mlingo umasankhidwa payekha kwa wodwala aliyense. Kuvulala kumachitika mu mphindi 0 mpaka 15. musanadye kapena mutamaliza kudya.

Glulisin amagwiritsidwa ntchito pochiritsa regimens, kuphatikizapo kugwiritsa ntchito insulin yapakatikati kapena yayitali, kapena mawonekedwe awo. Komanso, mankhwalawa amatha kugwiritsidwa ntchito limodzi ndi mankhwala omwe ali ndi vuto la hypoglycemic, omwe amagwiritsidwa ntchito pakamwa.

Njira yothetsera vutoli imayendetsedwa ngati jakisoni wofinya kapena kulowetsedwa pogwiritsa ntchito pampu ya insulin. Jakisoni amachitika m'mbali mwa phewa, ntchafu, khomo lam'mimba lakunja. Ndipo kuyambitsa ndalama kudzera kulowetsedwa kosalekeza kumachitika mu peritoneum.

Ma zone a jakisoni ndi ma infusions ayenera kusinthidwa nthawi iliyonse. Kuthamanga kwa mayamwidwe, kuyamba ndi kutalika kwa zotsatirazi kumatsimikiziridwa ndi zinthu zingapo (zolimbitsa thupi, malo opangira jekeseni). Ponyowa mwachangu, mankhwalawa amayenera kuponyedwa m'malo oyambira kukhoma pamimba.

Ndikofunika kusamala kuti insulin Glulisin isalowe m'mitsempha yamagazi. Chifukwa chake, aliyense wodwala matenda ashuga ayenera kukhala wodalirika popereka insulin. Pambuyo pa jekeseni, tsamba la jekeseni limaletsedwa kutikita minofu.

Glulisin amaloledwa kuphatikizidwa ndi Isofan (insulin yaumunthu), koma Glulisin ayenera kukokedwa mu syringe yoyamba. Kuwongolera kwa SC kuyenera kuchitika pokhapokha posakaniza ndalama. Pankhaniyi, osakaniza a Isofan ndi Glulisin amaletsedwa kutumizidwa kudzera m'mitsempha.

Ngati insulin Glulisin imayendetsedwa pogwiritsa ntchito pampu, ndiye kuti kitacho chimayenera kusinthidwa maola 4 aliwonse, kutsatira malamulo a antiseptic. Ndi kulowetsedwa kwa kayendetsedwe ka mankhwala, mankhwalawa sayenera kukhala osakanikirana ndi njira zina kapena ma insulin.

Pankhani yogwiritsa ntchito pampu mosayenera kapena kuphwanya ntchito yake, matenda ashuga a ketoacidosis, hyperglycemia kapena ketosis angayambike. Popewa kupezeka kwa zinthu ngati izi, musanachite njirayi, muyenera kuphunzira malamulo mosamala ndi kuwerengera mosamala.

Musanagwiritse ntchito yankho, muyenera kuyang'ana kusinthasintha kwake, utoto wake ndikuwonetsetsa kuti mulibe tinthu tachilendo. Ngati mankhwalawo ndi amtambo, achikuda kapena osayera, ndiye kuti nzoletsedwa kugwiritsa ntchito.

Contraindication, mavuto, bongo

Insulin Glulizin sagwiritsidwa ntchito pochiza ana osaposa zaka 6, ndi hypoglycemia ndi hypersensitivity ku zigawo zake. Zotsatira zoyipa kwambiri ndizo hypoglycemia. Mawonekedwe amtundu wakhungu ndi kusokonezeka kwa metabolic ndizothekanso.

Nthawi zina zimakhala ndi vuto la neuropsychiatric monga kugona, kutopa, kufooka, kuluma, ndi mseru. Mutu, kusowa kwa chidwi, kusokonezeka kwa malingaliro ndi kusokonezeka kowonekera kumawonekeranso.

Nthawi zambiri, musanafike vuto la neuropsychiatric, zizindikiro za adrenergic anti-regulation zimachitika. Uku ndi njala, kusakwiya, tachycardia, chisangalalo chamanjenje, thukuta lozizira, nkhawa, kufinya khungu ndi kunjenjemera.

Ndizofunikira kudziwa kuti kuukira kwamphamvu kwa hypoglycemia, komwe kumachitika mobwerezabwereza, kumabweretsa kuwonongeka kwa NS. Komanso, nthawi zina, izi zitha kubweretsa imfa.

Kuphatikiza pa kutsika kwakuthwa kwa shuga, zovuta zakomweko zingachitike m'malo omwe jekeseni adapangidwira. Izi zimaphatikizapo hyperemia, kutupa ndi kuyabwa, nthawi zambiri mawonetseredwe awa amazimiririka pawokha pakulandila chithandizo. Nthawi zina, chifukwa chosagwirizana ndi kusintha kwa malo a insulin, wodwala matenda ashuga amatha kukhala ndi lipodystrophy.

Zizindikiro zokhudzana ndi hypersensitivity ndizothekanso:

• kuyabwa
• urticaria
• matumbo a ziwongo,
• chifuwa cholimba
• kutsutsika.

Matendawa:

Ngati mankhwala osokoneza bongo, hypoglycemia yamphamvu zosiyanasiyana ikhoza kuchitika. Ndi kuchepa pang'ono kwa shuga m'magazi, wodwalayo ayenera kumwa zakumwa kapena zinthu zokhala ndi shuga.

Ndi vuto lalikulu kwambiri komanso kusazindikira, s / c kapena v / m amathandizidwa ndi Dextrose kapena Glucagon. Wodwala akayambanso kuzindikira, ayenera kudya zakudya zopatsa mphamvu, zomwe zingapewe kuyambiranso.

Mwachidule za insulin Glulizin

Insulin Glulisine ndi analogue ya insulin ya anthu, yomwe imafanana ndi mahomoni awa. Koma mwachilengedwe, imagwira ntchito mwachangu komanso imakhala yochepa.

Glulisin imaperekedwa ngati yankho la subcutaneous makonzedwe. Chimawoneka ngati madzi owonekera popanda zosayera.

Mayina amalonda a mankhwala okhala ndi iye: Apidra, Epidera, Apidra Solostar. Cholinga chachikulu cha mankhwalawa ndikukhazikitsa kagayidwe ka glucose.

Malinga ndi zomwe zikuchitika, zabwino ndi zovuta izi:

• Amachita mofulumira kuposa mahomoni amunthu (+),
• imakwaniritsa kufunika kwa chakudya mu insulin (+),
• kuthekera kosagwirizana ndi mphamvu ya mankhwalawa m'magazi a shuga (-),
• mphamvu yayikulu - gawo limachepetsa shuga kuposa ma insulin ena (+).

Pharmacology ndi pharmacokinetics

Pambuyo pa subcutaneous makonzedwe, pali kuchepa kwa glucose chifukwa cha kukoka kwake kwa kugwiritsidwa ntchito kwake mu minofu komanso kupsinjika kwa njirazi mu chiwindi. Kuchitikaku kumayambira mphindi 10 jekeseni.

Ndi kukhazikitsidwa kwa Glulisin ndi insulini yokhazikika mphindi zochepa asanadye, wakale amakhala ndi mphamvu yolamulira pakatha kudya. The bioavailability wa chinthu pafupifupi 70%.

Kulumikizana ndi mapuloteni a plasma ndikosatheka. Amachotseredwa mwachangu kuposa momwe amachitira majekiseni amtundu wa anthu. Hafu ya moyo wa mphindi 13.5.

Zizindikiro, mavuto, bongo

Mankhwala amalembedwa motere:

• Mtundu woyamba wa shuga
• Type 2 shuga,
• Matenda a shuga kwa ana kuyambira zaka 6.

Contraindging poika mankhwala ali motere:

• achina,
• Hypersensitivity to glulisin,
• Hypersensitivity pamavuto othandizira a mankhwalawo.

Munthawi ya mankhwala ndi mankhwala, zimachitika zovuta.

Pafupipafupi zochitika zolakwika pamanambala, pomwe 4 ndizofala kwambiri, 3 nthawi zambiri, 2 ndizosowa, 1 ndiyosowa kwambiri:

Pa bongo wambiri, hypoglycemia ya zovuta zosiyanasiyana imawonedwa. Itha kuchitika nthawi yomweyo kapena kukula pang'onopang'ono.

Kutengera mphamvu ya insulin mankhwala, nthawi yayitali komanso kuuma kwa matendawa, zizindikiro za hypoglycemia zitha kusokonekera kwambiri. Wodwala ayenera kulingalira izi kuti ateteze vutolo munthawi yake. Kuti muchite izi, muyenera kukhala ndi shuga (maswiti, chokoleti, ma cubes opanda shuga) nanu.

Ndi hypoglycemia yolimbitsa komanso yolimbitsa, zinthu zomwe zimakhala ndi shuga zimatengedwa. Woopsa, komanso limodzi ndi kuwonongeka kwa chikumbumtima, jakisoni adzafunika.

Mpumulo wa hypoglycemia umachitika mothandizidwa ndi glucagon (s / c kapena i / m), yankho la glucose (i / v). Pakupita masiku atatu, mkhalidwe wa wodwalayo umayang'aniridwa. Popewa kukula kwa hypoglycemia wobwerezabwereza, ndikofunikira kumwa chakudya pakapita kanthawi.

Kuyanjana kwa mankhwala osokoneza bongo

Kumayambiriro kwa mankhwala omwe ali ndi insulin ya ultrashort, kuyanjana kwake ndi mankhwala ena kumazingidwa.

Mankhwala ambiri amatha kuthana ndi kagayidwe ka glucose, kukulitsa kapena kuchepetsa zotsatira za insulin. Asanalandire chithandizo, wodwala ayenera kudziwitsidwa kuti apewe mavuto.

Mankhwala otsatirawa amalimbikitsa zotsatira za Glulisin: Fluoxetine, othandizira a hypoglycemic mapiritsi, makamaka, sulfonylureas, sulfonamides, salicylates, fibrate, ACE inhibitors, Disopyramide, MAO inhibitors, Pentoxifylline, Propoxifen.

Mankhwala otsatirawa amachepetsa mphamvu ya mankhwala a insulin: atypical antipsychotic, sympathomimetics, kulera kwapakamwa, mahomoni a chithokomiro, glucagon, mahomoni achigololo achikazi, thiodiphenylamine, somatropin, diuretics, glucocorticosteroid mankhwala (GCS), proteinase inhibitors,

Pentamidine, beta-blockers, ndi clonidine amatumizidwa ku mankhwala omwe mosasamala angakhudze mphamvu ya chiwonetsero cha Glulisin ndi mulingo wa shuga (kuchepa ndi kuwonjezeka). Mowa ulinso ndi zomwezo.

Kusamala kwakukulu kumawonedwa popereka pioglitazone kwa odwala omwe ali ndi mtima matenda a mtima. Akaphatikizidwa, milandu ya kukhazikika kwa mtima idanenedwa mwa odwala omwe ali ndi chiyembekezo cha matendawa.

Ngati chithandizo cha pioglitazone sichitha kutha, ndikofunikira kuyang'anira momwe zinthu ziliri. Ngati zizindikiro zilizonse zamtima (kuwonda, kutupa) ziwoneka, kugwiritsa ntchito mankhwalawa kumachotsedwa.

Malangizo apadera

Wodwalayo ayenera kuganizira izi:

1. Ndi vuto la impso kapena kuphwanya ntchito yawo, kufunika kwa insulini kungachepe.
2. Ndi kukanika kwa chiwindi, kufunikira kumacheperanso.
3. Chifukwa cha kusowa kwa chidziwitso, mankhwalawa saikidwa kwa ana osakwana zaka 6.
4. Gwiritsani ntchito mosamala amayi apakati omwe ali ndi kuyang'anira pafupipafupi pazisonyezo.
5. Pa mkaka wa m`mawere, kusintha kwa mlingo ndi zakudya zimafunika.
6. Mukasintha kupita ku Glulisin kuchokera ku mahomoni ena chifukwa cha hypersensitivity, kuyesedwa kwa ziwengo kuyenera kuchitidwa kupatula kusagwirizana.

Kusintha kwa Mlingo

Kusintha kwa Mlingo kumachitika pa kusintha kwa mtundu wina wa mahomoni obayira. Mukasamutsa kuchokera ku insulin ya nyama kupita ku Glulisin, mlingo umakonda kusintha m'njira yochepetsera chomaliza. Kufunika kwa mankhwalawa kumasintha ndikusokonezeka kwam'maganizo / m'maganizo, munthawi ya matenda opatsirana.

Chiwembucho chimayendetsedwa mothandizidwa ndi mankhwala a mapiritsi a hypoglycemic. Ngati mutasintha gawo lililonse la pulogalamuyi, mungafunike kusintha mlingo wa Glulisin.

Nthawi zambiri za hyperglycemia / hypoglycemia, zotsatirazi zomwe zimadalira mlingo zimafotokozedwa kaye musanayambe kuchuluka kwa mankhwalawa:

• njira ndi malo operekera mankhwala,
• Kutsatira njira zamankhwala,
• kumwa mankhwala ena limodzi
• psycho-state state.

Zowonjezera

Alumali moyo mutatsegula - mwezi

Kusungirako - kuyambira pa +2 mpaka + 8ºC. Osati kuzizira!

Kupumula ndikumvera mankhwala.

Glulisin ndiwofanana ndi insulin ya anthu:

• Insuman Rapid,
• Humulin
• Humodar
• Gensulin P,
• Vosulin P,
• Khalid.

Glulisin ndi mahashoni a ultrashort wokhazikitsa kagayidwe ka glucose. Amayikidwa limodzi ndi ma insulin ena, poganizira masankho omwe adasankhidwa. Musanagwiritse ntchito, ndikofunikira kuphunzira malangizo ndi kulumikizana ndi mankhwala ena.

Adalimbikitsa Nkhani Zina Zogwirizana

Zotsatira za pharmacological

Mankhwalawa ndi njira yofananiranso yamankhwala a insulin. Mphamvu yakuchitapo kanthu ndi yofanana ndi imelo yomwe imapangidwa ndi kapamba wabwino. Glulisin amachita zinthu mwachangu komanso amakhala ndi mphamvu yayitali.

Pambuyo makonzedwe kwa thupi (subcutaneously), timadzi timayamba kukhazikitsa kagayidwe kazachilengedwe.

Thupi limachepetsa kuchuluka kwa shuga m'magazi, limalimbikitsa mayamwidwe ake ndi minyewa, makamaka minofu yamatumbo ndi minofu ya adipose. Amalepheretsa mapangidwe a glucose mu zimakhala za chiwindi. Kuchulukitsa mapuloteni.

Kafukufuku wachipatala akuwonetsa kuti glulisin, womwe umaperekedwa kwa mphindi ziwiri asanadye, umaperekanso kuchuluka kwa shuga m'magazi momwe munthu amasungunulira insulin, yoyendetsedwa ndi theka la ola asanadye.

Zochita za insulin sizisintha mwa anthu amitundu yosiyanasiyana.

Pharmacokinetics

Pambuyo subcutaneous makonzedwe a mankhwala, pazenera ambiri mu magazi amafika pambuyo mphindi 55. Nthawi yayitali yakukhala mankhwala omwe ali m'magazi ndi mphindi 161. Ndi subcutaneous makonzedwe a mankhwalawa m'dera lakhomopo khoma kapena phewa, mayamwidwe mwachangu kuposa kukhazikitsa kwa mankhwala mu ntchafu. Bioavailability pafupifupi 70%. Kuchotsa theka-moyo pafupifupi mphindi 18.

Pambuyo pakuyendetsa pang'onopang'ono, glulisin imachotsedwako mwachangu kuposa insulin yamunthu yomweyo. Ndi kuwonongeka kwa impso, kuthamanga kwa kuyambira kwa zomwe zimafunikira kumakhazikika. Zambiri pazakusintha kwamatenda a insulin mwa okalamba sizinaphunzitsidwe mokwanira.

Kodi kumwa insulini glulisin?

Imaperekedwa pang'onopang'ono 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni. Simungathe kusakaniza mitundu ingapo ya insulini mu syringe yomweyo, ngakhale kuti wodwalayo akhoza kupatsidwa ma insulin osiyanasiyana. Kubwezeretsanso yankho lisanayambike makonzedwe ake.

Musanagwiritse ntchito, muyenera kuyang'ana botolo. Ndikothekanso kusungitsa yankho mu syringe pokhapokha ngati yankho likuwonekera komanso lilibe tinthu tambiri.

Malangizo ogwiritsa ntchito cholembera

Khola lomweli liyenera kugwiritsidwa ntchito ndi wodwala m'modzi. Ngati yawonongeka, saloledwa kuigwiritsa ntchito. Musanagwiritse ntchito cholembera, fufuzani mosamala cartridge. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka komanso lopanda zosayera. Cholembera chopanda kanthu ziyenera kutayidwa ngati zinyalala za m'nyumba.

Mankhwalawa kutumikiridwa subcutaneously 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo pa jekeseni, simungathe kufinya jakisoni.

Pambuyo pochotsa kapu, tikulimbikitsidwa kuti mulembe mayendedwe ndi yankho. Kenako ikani singano mosamala ndi cholembera. Mu chipangizo chatsopano, chizindikiro cha mankhwalawa chimawonetsa "8". Ntchito zina, ziyenera kuyikidwa pambali pa chizindikiro "2". Kanikizani batani la dispenser njira yonse.

Kugwira chiwongoladzanja, chotsani thovu lamkati podina. Ngati zonse zachitika molondola, dontho laling'ono la insulini limawonekera pamphumi ya singano. Chipangizocho chimakuthandizani kuti muyike mlingo kuchokera pa 2 mpaka 40 mayunitsi. Izi zitha kuchitika ndikutembenuza chotumiza. Kulipiritsa, batani la dispenser likulimbikitsidwa kuti lizikokedwa njira yonse.

Ikani singano m'matumba a subcutaneous. Kenako dinani batani njira yonse. Asanachotsere singano, iyenera kuchitidwa kwa masekondi 10. Pambuyo pa jakisoni, chotsani ndikuchotsa singano. Mulingo wake ukuonetsa kuchuluka kwa insulini yomwe imatsala mu syringe.

Ngati cholembera sichingagwire ntchito molondola, ndiye kuti yankho limatha kutengedwa kuchokera ku cartridge kupita ku syringe.

Zotsatira zoyipa za insulin glulisin

Zotsatira zoyipa kwambiri za insulin ndi hypoglycemia. Itha kuchitika chifukwa chogwiritsa ntchito mlingo waukulu wa mankhwalawa. Zizindikiro zakuchepa kwa shuga m'magazi zimayamba pang'onopang'ono:

• thukuta lozizira
• khungu komanso kuzirala kwa khungu,
• kutopa kwambiri
• chisangalalo
• zosokoneza zowoneka
• kunjenjemera
• nkhawa zazikulu
• chisokonezo, zovuta kuyang'ana,
• kumva kupweteka m'mutu,
• palpitations.

Hypoglycemia ikhoza kuchuluka. Uku ndikuwopseza moyo, chifukwa kumayambitsa kusokonezeka kwa ubongo, ndipo m'malo ovuta kwambiri - imfa.

Pa khungu

Pa malo a jakisoni, kuyabwa ndi kutupa kumachitika. Kuchita koteroko kwa thupi kumakhala kwakanthawi, ndipo simuyenera kumwa mankhwala kuti muchotse. Mwina chitukuko cha lipodystrophy mwa akazi pamalo opangira jakisoni. Izi zimachitika ngati zalembedwa pamalo amodzi. Kuti izi zisachitike, tsamba la jakisalo liyenera kusinthidwa.

Ndizachilendo kwambiri kuti mankhwala amatha kuyambitsa ziwopsezo.

Gwiritsani ntchito pa nthawi yoyembekezera

Pali umboni wochepa wokhudza kugwiritsa ntchito mankhwalawa panthawi ya bere komanso poyamwitsa. Kafukufuku wazinyama wa mankhwalawa sanawonetse zotsatira zam'mimba.

Popereka mankhwala awa kwa amayi apakati, muyenera kusamala kwambiri. Ndikofunikira kuyeza shuga m'magazi.

Odwala omwe ali ndi matenda osokoneza bongo amafunika kuwunika kuchuluka kwa shuga m'magazi. Pa trimester yoyamba, zofunika za insulin zimatha kuchepera pang'ono. Kaya insulin idutsa mkaka wa m'mawere sichikudziwika.

Glulisin insulin kwambiri

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo mlingo wake umatha kukhala wosiyana - kuchokera wofatsa mpaka wovuta.

Magawo a hypoglycemia ofatsa amaletsedwa kugwiritsa ntchito shuga kapena shuga. Ndikulimbikitsidwa kuti odwala nthawi zonse azikhala ndi maswiti, makeke, msuzi wokoma, kapena zidutswa za shuga woyengedwa nawo limodzi.

Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo mlingo wake umatha kukhala wosiyana - kuchokera wofatsa mpaka wovuta.

Ndi kuchuluka kwambiri kwa hypoglycemia, munthu amasiya kuzindikira. Glucagon kapena dextrose amaperekedwa ngati thandizo loyamba. Ngati palibe chochitika pakayendetsedwe ka glucagon, ndiye kuti jakisoni yemweyo imabwerezedwa. Pambuyo podzikanso, muyenera kupatsa wodwalayo tiyi wokoma.

Kuyenderana ndi mowa

Kumwa mowa kumatha kuyambitsa hypoglycemia.

Ma fanizo a Glulisin ndi awa:

• Apidra
• Novorapid Flekspen,
• Epidera
• insulin isophane.

Novorapid (NovoRapid) - analogue ya insulin ya anthu

Kukonzekera kwa Isofan insulin (Isofan insulin)

Momwe muyenera kuperekera insulin? Njira yolowa ndi insulin

Wopanga

Amapangidwa ku bizinesi Sanofi-Aventis Deutschland GmbH, Germany.

Ivan, wazaka 50, wodwala matenda a kubadwa kwa matenda, ku Moscow: “Mothandizidwa ndi Apidra, ndizotheka kuyendetsa zizindikiro za glycemia mwa odwala matenda ashuga a mtundu woyamba. Ndikupangira kuperekera insulin musanadye. Imathimitsa mayendedwe abwino a zizindikilo za shuga. ”

Svetlana, wazaka 49, wasayansi ya matenda ashuga, Izhevsk: "Glulisin ndi imodzi mwazinthu zabwino kwambiri. Odwala amalekerera bwino, koma malinga ndi kuchuluka ndi ma regimens. Hypoglycemia ndiosowa kwambiri. "

Andrei, wazaka 45, ku St. Petersburg: "Glulizin siyambitsa shuga kwambiri, zomwe ndi zofunika kwa ine monga wodwala matenda ashuga" wodziwa zambiri ". Malo pambuyo pobayidwa sikupweteka kapena kutupa. Mukatha kudya, kuwerenga kwa glucose ndikwabwinobwino. ”

Olga, wazaka 50, Tula: "Ma insulini akale ankandipangitsa kuti ndizizindikira, ndipo malowo anali opweteka. Glulisin samayambitsa zizindikiro zotere. Ndikosavuta kugwiritsa ntchito cholembera ndipo, koposa zonse, ndizothandiza. ”

Lidiya, wazaka 58, Rostov-on-Don: “Chifukwa cha Glulizin, ndimatha kudya shuga wambiri ndikatha kudya. Ndimatsata zakudya mosamala ndikuwerengera mlingo wa mankhwalawo. Palibe zochitika za hypoglycemia. ”

Insulin glulisine (Insulin glulisine): dzina lamalonda, mawonekedwe, malangizo ogwiritsira ntchito

Mtundu wa matenda ashupi amtundu woyamba, wodwala amatha kugwiritsa ntchito insulin yofulumira (yofulumira), yochepa, yapakati, yayitali komanso yosakaniza. Yemwe angafotokozere za mtundu wokwanira wa mankhwala zimadalira munthu payekha. Ngati mukufuna insulin ya ultrashort, Glulisin amagwiritsidwa ntchito.

Njira yothetsera jakisoni yotchedwa "Insulin Glulisin" imagulidwa m'masitolo ndi odwala omwe ali ndi matenda a shuga.

Mankhwalawa amafunikira kuti anthu achepetse shuga, komanso kuwonjezera mankhwalawa. Ichi ndiye, choyambirira, insulin.

Ndi gawo limodzi lama mankhwala ena a odwala matenda ashuga. Katunduyu ali ndi tanthauzo la hypoglycemic.

Ichi ndi analogue a insulin ya anthu, omwe amafanana ndi mahomoni awa. Koma mwachilengedwe chake, chimagwira ntchito mwachangu ndipo chimakhala ndi zotsatira zazifupi.

Mlingo ndi makonzedwe

Njira imeneyi imagwiritsidwa ntchito pang'onopang'ono mphindi 15 musanadye. Mlingo umasankhidwa payekha.

Ndizotheka kugwiritsa ntchito makina ogwiritsa ntchito pampu. Chofunikira cha tsiku ndi tsiku cha insulin nthawi zambiri chimakhala cha 0,5. pa kilogalamu imodzi iliyonse: magawo awiri mwa magawo atatu aliwonse amakhala ndi insulin asanadye chakudya. Ndipo gawo limodzi mwa magawo atatu ali kuseri kwa insulin (basal).

Mankhwala "Apidra" ("Epidera"): malongosoledwe

Tiyeni tiganizire za mankhwalawa mwatsatanetsatane.

Apidra insulin imagwiritsidwa ntchito pochiza matenda a shuga kwa ana kuyambira wazaka zisanu ndi chimodzi, ndipo imagwiritsidwanso ntchito kwa achikulire. Kukonzekera kumakhala ndi ma milligram 3,49 a chinthu chachikulu.

Izi zitha kufananizidwa ndi 100 IU (International Units) ya mahomoni amunthu.

Zothandizira zina zimaphatikizapo jakisoni wamadzi limodzi ndi m-cresol, chloride ndi sodium hydroxide, hydrochloric acid, trometamol ndi polysorbate.

Apidra insulin imagulitsidwa mu botolo la mamililita 10 kapena makilogalamu atatu a millilita. Njira yoyamba imakhala ndi katoni, ndipo yachiwiri imayikidwa mu CD. M'mawu omaliza, pali makatoni asanu omwe amalembetsa cholembera (kutanthauza syringe), yomwe imatchedwa "OptiPen" (iyi ndiye cholembera zotayika).

Wopangayo amapanganso njira yosiyanitsira cartridge ya OptiKlik. Mwamtheradi muzopopera zonse mumakhala madzi amadzimadzi osakhala ndi mtundu.

Apidra SoloStar

Gawo lomwe limagwira ntchito mmenemo limapezekanso ndendende monga momwe munasankhira kale. "Insulin glulisin" wokhala ndi dzina la malonda "Apollo brand SoloStar" ali ndi zotsutsana zotsatirazi:

• Kukhalapo kwa odwala a hypoglycemia ndi hypersensitivity a thupi kumunsi kapena wothandizika pazinthu izi.
• Nthawi yaubwana imafika zaka zisanu ndi chimodzi.

Mankhwala a Apidra ndi Apidra Solostar angagulidwe pa intaneti iliyonse ya pharmacy.

Zobisika za kugwiritsa ntchito mankhwalawa

"Insulin glulisin" imakhala yofanana ndi anthu. Kupatula kokha ndi nthawi yowonekera, yomwe ndiyofupikitsa. Ndikokwanira kupatsa wodwalayo jakisoni imodzi yokha ya mankhwalawa, chifukwa pakatha mphindi 15 amva bwino mu mkhalidwe wake.

Njira zolowetsera zimatha kusiyanasiyana. Mwachitsanzo, wothandizirayu amadzipaka pang'onopang'ono m'malo ena kenako, ndi kugwiritsa ntchito pampu ya insulin, njirayi imatha. Kulowetsedwa kumatha kuchitidwa popanda kusokoneza, komwe kumachitika m'mafuta am'madzi mwachindunji pansi pa khungu.

Ndondomeko iyenera kuchitidwa musanadye kapena pambuyo chakudya, koma osati yomweyo. Jakisoni wotsekemera amachitika bwino m'mimba, komanso amaloledwa paphewa, ndipo ntchafu yake ndiyabwino. Koma kulowetsedwa kutha kuchitidwa kokha m'mimba. Ndi madokotala okha omwe angatchule dongosolo la mankhwala. Mankhwalawa amagwiritsidwa ntchito kupatsa insulin nthawi yayitali kapena yapakatikati.

Amaloledwa kuphatikiza kulowetsa kwa "Insulin glulisin" ndi mapiritsi (kugwiritsa ntchito mankhwala a hypoglycemic).

Mlingo ndi kusankha kwa mankhwalawo kumatsimikiziridwa ndi adotolo, popeza wodwalayo alibe ufulu wosankha yekha. Chowonadi ndi chakuti izi ndizodzaza ndi zotsatira zoyipa kwambiri.

Mwa malangizo ofunikira oti mugwiritse ntchito, mutha kupezanso malangizo oyendetsera madera akukhazikitsa mankhwala. Ndikofunikira kuti muchepetse kuwonongeka kwa mitsempha yamagazi.

Ndi malangizo enanso ati omwe angagwiritsidwe ntchito ndi Insulin Glulizin?

Zotsatira zoyipa za ntchito

Mphamvu yamkati yamanjenje, monga gawo la zotumphukira, imatha kuyankha ku Insulin Glulisine pokhazikitsa mwachangu kuchuluka kwa shuga kumayambiriro kwa zamankhwala. Kuyamba kwa ululu wammbuyo wam'mimba ndikotheka, komwe kumatha kusiyana mosakhalitsa. Pakati pazakhudzana ndi dermatological, ndikofunikira kutchula lipodystrophy pamalo operekera mankhwalawa mankhwalawa.

Ziwalo zam'maganizo zimatha kuyankha molakwika, komanso, kuchepa kwa mawonekedwe owonekera, omwe adzaphatikizidwenso ndi kuthamanga kwa kukhalapo kwa shuga m'magazi kumayambiriro kwa chithandizo. Izi zitha kukhala zosakhalitsa. Monga gawo logwiritsira ntchito chida ichi, zinthu zosiyanasiyana zomwe zimachitika sizimasiyana.

Zochizira

Glulin insulin ndi analogue (recombinant) ya insulin ya anthu. Mphamvu ya chochita chake ndiofanana ndi insulin wamba ya anthu. Glulisin amayamba mwachangu, koma amakhala ndi nthawi yofupikitsa kuposa insulin yaumunthu.

Insulin glulisin jekeseni pansi pakhungu pambuyo mphindi 10-20.

Njira makonzedwe a insulin glulisin ndi subcutaneous jakisoni kapena mosalekeza kulowetsedwa mu subcutaneous mafuta am'mimba kudzera pampu. Insulin imayendetsedwa posachedwa (0-15min.) Isanachitike, kapena mutangodya.

Matenda a shuga odwala matenda a insulin.

Zotsatira zoyipa

Hypersensitivity zimachitika (redness, kutupa kapena kuyabwa pa malo jakisoni). Maganizo ngati amenewa nthawi zambiri amakhala osakhalitsa, amawonongeka pomapitilira chithandizo. Nthawi zina pamakhala zochitika za lipodystrophy (kuphwanya kusinthana kwa malo a jakisoni m'dera lomwelo).

Thupi lawo siligwirizana (urticaria, kupuma movutikira, bronchospasm, kuyabwa, dermatitis), kuphatikizapo milandu ikuluikulu ya chiwonetsero cha thupi lawo (kuphatikizapo anaphylactic), yomwe ingawononge moyo.

CHOKONZEDWA MALO OGULITSA

«Kunenepa"- zovuta za antioxidant zomwe zimapereka moyo watsopano kwa onse metabolic syndrome ndi matenda a shuga. Kuchita bwino ndi chitetezo cha mankhwalawa zimatsimikiziridwa. Mankhwala akulimbikitsidwa kuti agwiritsidwe ntchito ndi Russian Diabetes Association. Dziwani zambiri >>>

Kupatsa ana ntchito

Insulin yamtunduwu imatha kuperekedwa kwa ana azaka zopitilira zisanu ndi chimodzi.