Rosuvastatin: malangizo ogwiritsa ntchito, kuchenjeza ndi kuwunika

Kufotokozera kogwirizana ndi 18.07.2014

• Dzina lachi Latin: Rosuvastatin
• Code ya ATX: C10AA07
• Chithandizo: Rosuvastatin (Rosuvastatin)
• Wopanga: CANONPHARMA, Russia

Piritsi lililonse ndi filimu. Katundu wamkulu ndi rosuvastatin.

• wowuma chimanga
• magnesium wakuba,
• cellcrystalline mapadi,
• povidone
• calcium hydrogen phosphate dihydrate.

Zomwe zimapangidwa ndi chipolopolo:

• selecate AQ-01032 ofiira,
• titanium dioxide
• hypopellose,
• macrogol-400,
• macrogol-6000.

Kutengera mlingo (10 mg, 20 mg, 40 mg), kapangidwe ka mapiritsi amasintha.

Zizindikiro zogwiritsidwa ntchito

Mankhwala Rosuvastatin ayenera kumwedwa:

• at hypercholesterolemia (kuwonjezera pa kadyedwe kuti njira zina zochiritsira zikhale zopanda phindu),
• at hypertriglyceridemia (monga chakudya).

Contraindication

Mankhwalawa amadziwikiridwa kwa anthu omwe ali ndi hypersensitivity ku zigawo za mankhwala.

Komanso, matenda otsatirawa ndi contraindication kumwa mankhwala oyamba:

At wa mimba ndi yoyamwitsa mankhwalawa akuphatikizidwanso.

Chenjezo limalangizidwa kumwa mankhwalawa kwa anthu omwe ali ndi:

• sepsis,
• nthawi ya opaleshoni,
• at kusokonezeka kwa endocrine,
• ndi kuvulala.

Muyeneranso kusamala pakugwiritsa ntchito Rosuvastatin kwa oimira mpikisano waku Asia.

Kwa anthu ochepera zaka 18 komanso atatha zaka 65, mankhwalawa ndi osavomerezeka.

Zotsatira zoyipa

Mankhwalawa ali ndi zovuta zingapo zoyipa zomwe zimayambitsidwa:

Makina a minofu ndi mafupa:

Machitidwe amanjenje:

Machitidwe opatsirana:

Njira zamankhwala:

• matenda
• kupweteka m'mimba.

Matumbo:

Mulingo wamtima:

Kuchita

Maantacid imatha kuthandizidwa pokhapokha ngati patapita nthawi (pafupifupi maola awiri) mutamwa mankhwalawa, chifukwa kugwiritsa ntchito kwawo kumayambitsa kutsika kwa Rosuvastatin.

Erythromycin komanso sayenera kumwa ndi rosuvastatin, popeza mphamvu ya kumwa mankhwalawo limodzi imachepa.

Pani Pharmacy

Maphunziro: Anamaliza maphunziro awo ku Rivne State Basic Medical College ndi digiri ku Pharmacy. Anamaliza maphunziro ake ku Vinnitsa State Medical University. M.I. Pirogov ndi gulu lozindikira kutengera izi.

Zokumana nazo: Kuyambira 2003 mpaka 2013, amagwira ntchito monga mfesi ya zamankhwala komanso manijala wa khemisi. Anapatsidwa makalata komanso kusiyanasiyana kwa zaka zambiri akugwira ntchito molimbika. Zolemba pamitu yachipatala zidasindikizidwa m'mabuku azofalitsa (manyuzipepala) komanso pazamasamba osiyanasiyana pa intaneti.

Kwa iwo omwe triglycerides sanakwezedwe mpaka pamlingo wovuta, sindikukulangizani rosuvastine, pali zovuta zambiri, masewerawa sayenera kandulo, ndimaweruza ndekha. Tsopano ndimavomereza dibikor, nthawi zambiri LDL ndi HDL, ndiyofatsa, komanso yothandiza. Ngati simungathe kuchita popanda statin, ndibwino kulumikiza dibicor kuti muchepetse mavuto, dotolo wandiuza choncho.

Ndimatenga analogue a mankhwalawa, amatchedwa Rosuvastatin-SZ. Katswiri wamtima adamulembera kwa nthawi yayitali, kuti aletse vuto la mtima, adalimbana ndi ntchito yotsitsa cholesterol bwino, ndikuchepetsa kuchoka pa 7.9 mpaka 5.5 kupitilira theka laka. Nthawi zambiri amalemba za zoyipa, koma panalibe zomwezi, ndimamva bwino.

Mawonekedwe ndi kipimo

Rosuvastatin ndi wa mankhwala ochepetsa lipid otsika a gulu la statin. Subclass - HMG-CoA reductase inhibitors. Chifukwa cha kuphatikizika kwa mankhwalawa, kuchuluka kwa lipids kumachepa, zochitika za ma cell a LDL zimachulukitsa, ndipo chifukwa chake, zimagwira mwachangu ndipo zimachotsedwa m'magazi. Kuphatikiza apo, monga ma statins ena, rosuvastatin imathandizanso endothelium, ikulepheretsa kukanika kwake (imalepheretsa kukula kwa atherosclerosis koyambirira), pakhoma lamankhwala (limateteza ku cholesterol kachigawo). Kwakukulu isoenzymenawo kagayidwe rosuvastatin - CYP2C9

Njira yotulutsira ya rosuvastatin ndi magome. Amakhala ndi ma pinki okongola, onyansa mbali zonse, yokutidwa ndi filimu. Pa cholakwika, zinthu zamkati zimakhala pafupi ndi zoyera. Chofunikira chachikulu pa piritsi - calcium rosuvastatin - chimapezeka mu 5 mg, 10 mg ndi 20 mg. Kutengera mlingo, mapiritsi ndi osiyana. Njira zozungulira zomwe mungagwiritsire ntchito ndi 5 mg ndi 20 mg, mawonekedwe ake ndi 10 mg ndi 40 mg.

Muzipatala, mutha kugula mapaketi okhala ndi makatoni okhala ndi matuza a 6, 10, 14, 15 kapena 30 pachilichonse, kutengera mlingo, kapena 30 ndi 60 zidutswa mumitsuko. Kuphatikiza pa chinthu chachikulu (kunena, rosuvastatin - dzina ladziko lonse), kapangidwe kake ka mankhwalawa kamaphatikizanso zinthu zina zowonjezera: povidone, starch ya chimanga, magnesium stearate, microcrystalline cellulose. Kuphatikizika kwa chipolalachi kumaphatikizapo kusakaniza kowuma: talc, macrogol, titanium dioxide, iron oxide (ofiira). Kutengera ndi wopanga, izi zimatha kusiyanasiyana.

Pamwambapa, tidasanthula kapangidwe kazomwe amapanga rosuvastatin Canonpharma (dziko - Russia). Komanso masiku ano tilingalira za fanizo la mankhwalawa malinga ndi radar ya mankhwala (rejista yamankhwala), ndikuwona kuti ndi ndani wopanga mashelufu azamankhwala omwe ali bwino pamtengo komanso bwino.

Zotsatira zoyipa

Mothandizidwa ndi malangizo a kuchipatala omwe amaperekedwa tsiku lililonse, mankhwala a rosuvastatin amayambitsa mavuto ambiri nthawi zambiri. Kupanda kutero, ngati mulandila mosayenera, mankhwalawa amatha kubweretsa zabwino komanso zovulaza. Zomwe zimayambitsa zovuta zimayikidwa malinga ndi gulu la WHO (WHO): nthawi zambiri, nthawi zambiri, milandu yokhayokha, yodziwika bwino, kuyeretsa sikudziwika. Tsopano tiwunikira mavuto omwe ali ndi vuto lililonse ndipo akuyenera kuganiziridwira mankhwalawa.

• Mavuto am'magulu amachitidwe a anthu: kukhazikitsidwa kwa mtundu wa 2 wa insulin osadalira insulin.
• Matenda osavomerezeka ndi reactivity: hypersensitivity zimachitika, urticaria, edema.
• CNS - kupweteka m'mutu, chizungulire.
• Zipangizo zam'mafupa ndi minofu - kupweteka kwa minofu (myalgia), myopathy, rhabdomyolysis chifukwa cha kulephera kwa impso, nthawi zina osowa (1 mwa 10,000) - chitetezo chosagwirizana ndi myopathy. Pafupipafupi - arthralgia, myositis. Ndikofunika kuyang'anira kuchuluka kwa ntchito ya creatine phosphokinase enzyme komanso kuwonjezereka kwa ndende (kasanu kapena kupitirira mtengo uwu), chithandizo cha rosuvastatin chathetsedwa.
• Matumbo am'mimba - kupweteka kwam'mimba, kudzimbidwa, mseru.
• Urinary system - mapuloteni mu mkodzo (proteinuria), nthawi zambiri amakomoka nthawi ya chithandizo ndipo sikuti ndi chizindikiro cha matenda aimpso.
• Khungu ndi PUFA - kuyabwa, urticaria, zotupa za erythematous.
• Chiwindi - kusintha kochokera pamankhwala mu michere ya chiwindi - transaminases ndi kuwonjezeka kulikonse kwa iwo.
• Ma labotale - bilirubin, alkaline phosphatase, ntchito ya gamma-glutamintranspeptidase imatha kuchuluka, kawirikawiri, madandaulo ogwira ntchito ochokera ku chithokomiro cha chithokomiro angadziwike.
• Zizindikiro zina ndi asthenia.

Nthawi zambiri odwala amafunsa funso - kodi kutentha kumawonjezeka mukamatenga rosuvastatin? Ayi, sichoncho. Ndikufuna kudziwa kuti palibe kuyanjana ndi ma statins omwe amamwa mowa, kotero kuti nthawi yamankhwala, odwala ayenera kusiya kumwa mowa, mwinanso kuopsa kwa zotsatirapo kumawonjezeka nthawi zina, ndipo phindu lomwe lingachitike - ayi, ayi.

Malangizo ogwiritsira ntchito

Nthawi zambiri, mulingo woyambirira wa rosuvastatin ndi 5-10 mg patsiku, malingana ndi zolinga zamankhwala komanso chikhalidwe cha wodwalayo ndi thupi lake. Asanalandire chithandizo, chithandizo chamankhwala chofuna kuchepetsa magazi a cholesterol ziyenera kuonedwa. Zingatheke bwanji tengani bwino rosuvastatin?

Mankhwala amatha kuledzera mosasamala chakudya, nthawi yomweyo mankhwala onse a tsiku lililonse 1 nthawi. Osagawa piritsi, osamatafuna kapena kuwaza, imwani pakamwa pathunthu, ndi kapu yamadzi. Mlingo umasankhidwa payekha komanso mosamala kwambiri. Ngati ndi kotheka, pakatha milungu inayi, dokotala yemwe akupezekapo amatha kuwonjezera mlingo kuti akwaniritse zomwe mukufuna.

Posankha kukonzekera mlingo wa 40 mg wa tsiku lililonse, chiopsezo chodwala chimawonjezeka, kotero kuchuluka kwa mankhwalawa kumayikidwa pazigawo zazikulu za hypercholesterolemia ndi chiopsezo chachikulu cha zovuta kuchokera ku mtima ndi mtima, ngati kuchuluka kwa 20 mg sikunapereke zotsatira zomwe zimafunidwa kale. Ndikofunikira kuchita kuyang'anira kuyamwa kwa zamadzimadzi patatha masabata 2-4 kuyambira pakuyamba chithandizo kapena kuwonjezeka kwa mlingo.

Ngati wodwala ali ndi nthenda yachilendo ya impso, chiwindi, minyewa ya mafupa, minyewa yotupa, ndiye kuti mlingo woyenera kwa iye ndi 5 mg patsiku. Tsopano tiwuzeni kuti zitenge nthawi yayitali bwanji kutenga rosuvastatin. Njira ya mankhwalawa imayikidwa payekhapayekha, koma nthawi yake imakhala mwezi umodzi.

Gwiritsani ntchito pa nthawi yoyembekezera

Zofanana ndi ma statins ena, rosuvastatin pa nthawi yoyembekezera komanso mkaka wa m`mawere sichilandiridwa.

Zaka za ana ndi imodzi mwazosokoneza za rosuvastatin. Palibe kafukufuku wokhudzidwa kwathunthu wazokhudzana ndi momwe thupi la ana lakhalira likuchitika, chifukwa chake statin imeneyi sigwiritsidwa ntchito pochita ana.

Mtengo wa mankhwala

Kwa odwala ambiri, kuwonjezera pa mtundu ndi zotsatira za mankhwalawo, mtengo wake uli m'malo ofunikira. Kwa rosuvastatin, mtengo wake ndiwofanana kwambiri poyerekeza ndi mitengo ya ma lipid ena otsitsa lipid. Kodi rosuvastatin amatenga ndalama zingati? Kutengera dera, mtengo wake ndi wosiyana. Ku Russia ku pharmacies aku Moscow, mankhwala amagulitsidwa pamtengo wotsatirawu:

• mapiritsi 30 a 5 mg - mtengo kuchokera ku 510 rubles
• mapiritsi 30 a 10 mg - mtengo kuchokera ku ma ruble 540
• mapiritsi 30 a 20 mg aliyense - mtengo kuchokera ma ruble 850

Ku Ukraine mitengo ya rosuvastatin ndi yotsika kwambiri. Mtengo wapakati muma pharmacies aku Kiev ali munjira izi:

• kwa 28 ma PC. 5 mg iliyonse - mtengo kuchokera ku 130 UAH
• kwa 28 ma PC. 10 mg iliyonse - mtengo kuchokera ku 150 UAH
• kwa 28 ma PC. 20 mg iliyonse - mtengo kuchokera ku 230 UAH.

Inde, mitengo imadalira kampani yopanga, mawonekedwe a maunyolo am'mapiritsi ndi malingaliro enieni amitengo yamadera amodzi mdziko muno.

Kugwiritsa Ntchito

Mwa akatswiri azachipatala, ndemanga za rosuvastatin ndizabwino kwambiri. Amawerengedwa ngati mankhwala amakono osankha hypercholesterolemia omwe ali ndi mtengo wabwino / mtengo wabwino. Nthawi zambiri amalembedwa kuti azilamulira atherosulinosis. Mwa kukhazikika pamlingo wa lipid, chiwopsezo cha matenda a mtima ndi mikwingwirizo chimachepetsedwa.

Petrenkovich V.O. Dokotala wothandizira mabanja kwambiri, Vinnitsa: “Pochita izi, ndakhala ndikugwiritsa ntchito rosuvastatin kwakanthawi komanso nthawi zambiri. Kwa odwala, ndimakonda kuwalemba ngati Roxer. Nthawi zonse, ndimakhala ndi chipatala. Odwala kwenikweni samadandaula kuti zimachitika, chithandizo chokwanira chimalekeredwa. Mankhwala ndi ochepa pamtengo "

Ngakhale kuti nthawi zambiri anthu amachita mantha ndi mndandanda wazotsatira zomwe zingachitike atatenga rosuvastatin, mwa omwe sanatchulepo amanenapo chilichonse. Mtengo ndi zomwe zikuyembekezeka kutenga rosuvastatin zimatsimikizira cholinga chake.

Gorelkin Pavel, Novorossiysk: “Kwa zaka zingapo tsopano, madokotala amati ndili ndi cholesterol yambiri. Zaka zanga 42, ndimachita mantha kwambiri kufa ndi vuto la mtima. Ku chipatala chachigawo, ndidalangizidwa kuti ndiyambe kumwa Suvardio. Patatha pafupifupi mwezi ndi theka, mayeso anga anakula bwino, zinakhala zosavuta pa moyo wanga. Nanga bwanji mtengo wake? Mtengo sukuluma kwambiri, kotero ndimatha kulipira. Ndipitiliza chithandizo "

Belchenko Z.I., wazaka 63, tawuni. Akhtyrsky: “Kwa zaka zambiri ndakhala ndikugwiritsa ntchito cholesterol yanga yayikulu ndi mankhwala wowerengeka. Zomwe sindinayesere, palibe chomwe chinandithandiza. Chaka chatha, mnansi wina adandiwuza kuti ndikaonane ndi dokotala watsopano kuchipatala. Kumeneku ndidayikidwa rosuvastatin. Ndidauzidwa izi zatsopano komanso zabwino kwambiri mankhwala. Ngakhale mtengo ndi wokwera kwambiri kwa ine, mitengo yake ndi mitengo, koma ndamwa kwa chaka chimodzi tsopano ndipo ndili ndi cholesterol yabwino. ”

Makashvili O.B., Zaka zoposa 50, Kerch: "Pothandizidwa ndi mchimwene wake, Tevastor adayamba kutsatira. Matenda anga a shuga adakula. Ndinapita ku chipatalako, komwe adasinthira mankhwalawo ndi mankhwala ena, koma pamtengo wofanana. Ndipo ndinazindikira kuti Tevastor sayenera kumwedwa ndi matenda ashuga. ”

Monga mukuwonera, malinga ndi kuwunika kwa madotolo ndi odwala onse, rosuvastatin ali ndi mtengo wabwino / chiyezo chabwino. Rosuvastatin ndi mankhwala amakono komanso othandiza. Kutsatira mosamalitsa malangizo azachipatala, ali ndi mbiri yayikulu yachitetezo ndipo amatha kuyesedwa ngati njira yayitali.

Kupanga ndi mawonekedwe a kumasulidwa

Mankhwala Rosuvastatin amapangidwa mwanjira ya mapiritsi, mapiritsi okhala ndi mafilimu opanga pakamwa (pakamwa). Ali ndi mtundu wa pinki kapena wapinki, wozungulira bwino komanso wamtundu wa biconvex.

Piritsi lililonse ndi filimu. Katundu wamkulu ndi rosuvastatin.

• wowuma chimanga
• magnesium wakuba,
• cellcrystalline mapadi,
• povidone
• calcium hydrogen phosphate dihydrate.

Zomwe zimapangidwa ndi chipolopolo:

• selecate AQ-01032 ofiira,
• titanium dioxide
• hypopellose,
• macrogol-400,
• macrogol-6000.

Kutengera mlingo (10 mg, 20 mg, 40 mg), kapangidwe ka mapiritsi amasintha.

Zotsatira za pharmacological

Rosuvastatin ndi lipid-kutsitsa wothandizila, wosankha mpikisano wa hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase, yomwe ndi enzyme yomwe imatembenuza 3-hydroxy-3-methylglutaryl CoA kukhala patsogolo pa cholesterol - mevalonate. Mankhwalawa amachulukitsa kuchuluka kwa ma LDL receptors (otsika kachulukidwe lipoproteins) pamaselo a chiwindi, chifukwa, kutsutsana ndi kukoka kwa LDL kumachulukitsidwa ndipo kaphatikizidwe ka VLDL (lipotroteins otsika kwambiri) kumalepheretseka. Mapeto ake, chiwerengero chonse cha VLDL ndi LDL chachepetsedwa.

Mothandizidwa ndi Rosuvastatin, kuchuluka kwa OXC (cholesterol yathunthu), cholesterol-LDL (cholesterol low density lipoproteins), TG (triglycerides), ApoB (apolipoprotein B), TG-VLDL ndi VL-VLDL yafupika. Mankhwalawa amalimbikitsa kuchuluka kwa HDL-C (cholesterol ya HDL) ndi ApoA-I (apolipoprotein A-I). Rosuvastatin amachepetsa index ya atherogenicity, kukonza lipid mbiri mwa odwala omwe ali ndi hypercholesterolemia.

Achire zotsatira za mankhwalawa amakula sabata yoyamba itatha kuyambika, kufikira pazofika sabata lachinayi la maphunzirowo.

Pharmacokinetics

Kuchuluka kwa plasma ndende yogwira ntchito kumafikira maola 5 mutatha Rosuvastatin. Mtheradi bioavailability pafupifupi 20%.

Kupanga kwakukulu kumachitika ndi chiwindi. Kuchuluka kwa magawidwe ndi malita 134. Pafupifupi 90% ya zinthu zomwe zimamangidwa ndimapuloteni a plasma (makamaka ndi albumin). Ma metabolites apamwamba ndi lactone metabolites (alibe ntchito ya pharmacological) ndi N-desmethylrosuvastatin (50% ochepera kuposa rosuvastatin).

Pafupifupi 90% ya mankhwalawa amatengedwa kudzera m'matumbo osasinthika, zotsalira ndi impso. Theka la moyo wa plasma ndi maola 19.

The pharmacokinetics wa rosuvastatin sayima pawokha jenda komanso msinkhu wodwala.

Mwa anthu a mpikisano wa a Mongoloid, pali kuchuluka kuwirikiza kawiri pazoyimira plasma yayikulu ya rosuvastatin ndi Median AUC (dera lomwe lili pansi pa nthawi yokhomerera) poyerekeza ndi odwala a Caucasoid, mwa amwenye kuchuluka kwambiri ndende ya plasma ndi a Median AUC akuwonjezeka nthawi 1.3, mwa oimira mpikisano wa Negroid magawo a pharmacokinetic ali ofanana ndi a ku Caucasians.

Kulephera kwaimpso pang'ono kapena pang'ono sikukhudza kwambiri kuchuluka kwa rosuvastatin komanso metabolite N-desmethylrosuvastatin. Kulephera kwambiri kwa impso, plasma ndende ya rosuvastatin imakwera pafupifupi katatu, ndipo N-desmethylrosuvastatin nthawi zisanu ndi zinayi. Odwala hemodialysis, ndende ya yogwira mankhwala pafupifupi 50% apamwamba.

Odwala omwe ali ndi vuto lalikulu la chiwindi, theka la moyo wa rosuvastatin akhoza kuchulukitsidwa kawiri.

Mankhwala pa mimba ndi mkaka wa m`mawere

Rosuvastatin ndi ma statin ena amapangika pakubala. Pali umboni kuti mankhwalawa amakhudza kwambiri chitukuko cha mwana wosabadwayo, zimawonjezera chiopsezo chofuna kupatuka khanda. Amayi amisinkhu yobala omwe amatenga ma statins ayenera kugwiritsa ntchito mosamala njira zabwino zakulera.

Ngati mimba yosakonzekera yachitika, ndiye kuti kumwa mapiritsi a cholesterol yomweyo kusiya. Sizikulimbikitsidwa kuyamwitsa pakapita nthawi ya mankhwala ndi mankhwalawa.

Mlingo ndi njira yoyendetsera

Monga momwe malangizo agwiritsidwira ntchito, rosuvastatin amatengedwa pakamwa, osatafuna kapena kupera piritsi, kumeza lonse, kutsukidwa ndi madzi. Mankhwala amatha kutumikiridwa nthawi iliyonse ya tsiku, mosasamala nthawi yakudya.

Asanayambe mankhwala ndi Rosuvastatin, wodwalayo ayenera kuyamba kutsatira zakudya zapamwamba za hypocholesterolemic ndikupitilizabe kutsatira panthawi ya chithandizo. Mlingo wa mankhwalawa amayenera kusankhidwa payekha kutengera zolinga zamankhwala komanso chithandizo chamankhwala, pozindikira momwe zilili masiku ano.

• Mlingo woyambirira wa odwala omwe ayamba kumwa mankhwalawa, kapena kwa odwala omwe atengedwa kuchokera ku kutenga zina za HMG-CoA reductase, ayenera kukhala 5 kapena 10 mg ya mankhwala a Rosuvastatin 1 nthawi / tsiku. Mukamasankha koyamba mlingo, munthu ayenera kutsogoleredwa ndi cholesterol yokhala ndi vuto lomwe lingakhale ndi zovuta zamtima, komanso ndikofunikira kuwunika kuopsa kwa zotsatira zoyipa. Ngati ndi kotheka, mankhwalawa atha kuwonjezeka pambuyo pa masabata anayi (onani gawo la "Pharmacodynamics").
• Chifukwa chakukula kwa zotsatira zoyipa mukamamwa mlingo wa 40 mg, poyerekeza ndi mapiritsi ochepa a mankhwalawo (onani gawo "Zotsatira zoyipa"), ndikuwonjezera mlingo mpaka 40 mg pambuyo poti mlingo wowonjezereka ukhale wapamwamba kuposa momwe mankhwalawa amayambira milungu 4 Mankhwala amatha kuchitika kokha mwa odwala kwambiri hypercholesterolemia ndi chiwopsezo cha matenda a mtima (makamaka odwala omwe ali ndi achibale a hypercholesterolemia) omwe sanakwaniritse zotsatira zofunika za mankhwala akamamwa 20 mg, ndipo ndi ndani amene T kukhala kuyang'aniridwa ndi katswiri (onani. gawo "malangizo Special"). Makamaka kuwunika mosamala odwala omwe akulandira mankhwalawa 40 mg akulimbikitsidwa.

Mlingo wa 40 mg ndi osavomerezeka kwa odwala omwe sanakumaneko ndi dokotala. Pambuyo pamilungu ya 2-4 yothandizira komanso / kapena kuwonjezeka kwa mlingo wa Rosuvastatin, kuwunika kwa metabolidi ya lipid ndikofunikira (kusintha kwa mlingo ndikofunikira ngati pakufunika). Kugwiritsa ntchito mankhwalawa muyezo wapamwamba kuposa 40 mg sikulungamitsidwa pazokhudza kukwera kwa zotsatira zoyipa ndipo nthawi zambiri sizikulimbikitsidwa.

1. Ndi creatinine chilolezo cha 30-60 ml / min, Rosuvastatin ndi mankhwala koyamba 5 mg. Kugwiritsa ntchito mankhwala tsiku lililonse 40 mg ndi contraindicated. Odwala okhala ndi creatinine chilolezo chochepera 30 ml / min, komanso milandu ya matenda a chiwindi omwe amagwira ntchito, sanakhazikitsidwe.
2. Mlingo woyambira wothandizidwa ndi mtundu wa Mongoloid ndi 5 mg. Pa mlingo wa 40 mg, mankhwalawa saikidwa pagulu la odwala.
3. Kwa odwala omwe ali ndi genotypes c.521SS kapena s.421AA, mlingo woyenera wa tsiku ndi tsiku wa Rosuvastatin ndi 20 mg.
4. Muzochitika zotsogola kuti muthe kukulitsa myopathy, mlingo woyambirira ndi 5 mg, pazomwe 20 mg.
5. Mukamapereka mankhwala othandizira, ndikofunikira kuti muwunike kuyambika kwa myopathy.

Zotsatira zoyipa

Milandu yomwe imawonedwa pamankhwala nthawi zambiri imakhala yodalira mankhwala osatulutsidwa ndipo imangoyenda yokha.

Zotheka kuchita zoyipa (> 10% - nthawi zambiri,> 1% ndi 0,1% ndi 0,01% ndi Sasha. Katswiri wa zamankhwala wandiyambitsa rosuvastatin 1 tabu kamodzi pa usiku. Ndinayamba kumwa ndipo mtima wanga unayamba kugunda modabwitsa. - ndiye ndimatupa olemera, zimakhala ngati galimoto imagwira ntchito molimbika. Ndinaimitsa kumwa ndikumenyedwa kwadzidzidzi kwa mtima kwachilendo. Ndidawerenga maupangiri kuti mwina atha kuthana ndi mtima. Sindimayenera kumwa mpaka pano. Ndingachepetse bwanji cholesterol yanga tsopano?

Pali mankhwala angapo omwe ali ndi chimodzimodzi mankhwala monga rosuvastatin, chifukwa chake amatha kugwiritsidwa ntchito ngati njira zina. Komabe, musanagwiritse ntchito, ndikofunikira kuti mufunsane ndi dokotala.

Njira zina ndi izi:

Musanagule analog, funsani dokotala.