AUGMENTIN 625 - malangizo ogwiritsira ntchito, mtengo, ndemanga ndi analogi

Chonde, musanagule Augmentin, mapiritsi 625 mg, 14 ma PC., Onani zambiri za nkhaniyi ndi zomwe zili patsamba lawebusayiti la wopangiralo kapena tchulani mtundu wa mtundu winawake ndi woyang'anira kampani yathu!

Zomwe zikuwonetsedwa patsamba lino sizoperekedwa pagulu. Wopanga amakhala ndi ufulu wosintha kapangidwe kake, kapangidwe kake ndi katayidwe kake ka zinthu. Zithunzi zamalonda pazithunzi zomwe zaperekedwa pamndandanda wazomwe zili patsamba lino zimasiyana ndi zomwe zidachokera.

Zambiri pamutengo wa zinthu zomwe zawonetsedwa pamndandanda wazomwe zili patsamba lino zitha kusiyana ndi zomwe zimachitika panthawi yokhazikitsa dongosolo la zomwe zikugwirizana.

Wopanga

Zosakaniza zomwe zimagwira ntchito: amoxicillin (mu mawonekedwe a trihydrate) - 875 mg, clavulanic acid (monga mchere wa potaziyamu) - 125 mg.

Omwe amathandizira: magnesium stearate - 14,5 mg, sodium carboxymethyl - 29 mg, colloidal silicon dioxide - 10 mg, cellcrystalline cellulose - 396,5 mg.

Zomwe zimapangidwa ndi membrane wa filimuyi: titanium dioxide - 13.76 mg, hypromellose (5 cps) - 10.56 mg, hypromellose (15 cps) - 3.52 mg, macrogol 4000 - 2.08 mg, macrogol 6000 - 2.08 mg, dimethicone - 0,013 mg.

Zotsatira za pharmacological

Augmentin ndi antibacterial wodziwika bwino, bactericidal.

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira ku tizilombo tating'onoting'ono tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imagwira mokwanira motsutsana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal beta-lactamases a mtundu woyamba, omwe saletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu Augmentin ® kukonzekera kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Otsatirawa ndi ntchito ya vitro yosakanikirana ya amoxicillin ndi clavulanic acid.

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Ma gror-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus spp., Phatikizani. Streptococcus pyogene 1,2, Streptococcus agalactiae 1,2 (beta hemolytic streptococci) 1,2, Staphylococcus aureus (wogwira methicillin) 1, Staphylococcus saprophytaci (wogwira methicillin), coagulase-negative staphylococci (wogwira kwa).

Ma anaerobes a gram-positive: Clostridium spp., Peptococcus niger, Peptostreptococcus spp. Kuphatikiza Pusostreptococcus magnus, Peptostreptococcus micros.

Ma grram-negative aerobes: Bordetella pertussis, Haemophilus fuluwenza 1, Helicobacter pylori, Moraxella cocarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Ma gram alibe anaerobes: Bacteroides spp., Phatikizani Bacteroides fragilis, Capnocytophaga spp., Eikenella corrodens, Fusobacterium spp. Kuphatikiza Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Enanso: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Ma gror-negative aerobes: Escherichia coli 1, Klebsiella spp., Phatikizani Klebsiella oxetoca, Klebsiella pneumoniae 1, Proteus spp. Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Ma gror-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2, streptococcus group Viridans.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-hasi aerobes: Acinetobacter spp.

Zina: Chlamydia spp., Phatikizani Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Kwa mabakiteriya awa, kufunikira kwakanthawi kothandizirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 Zovuta za mitundu iyi ya mabakiteriya sizitulutsa beta-lactamase. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Zosakaniza zonse ziwiri za kukonzekera kwa Augmentin ® - amoxicillin ndi clavulanic acid - zimatengedwa mwachangu komanso mokwanira kuchokera m'mimba kuchokera pakamwa. Kuyamwa kwa yogwira mankhwala a Augmentin ® ndi mulingo woyenera kumwa mankhwala kumayambiriro kwa chakudya.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga 40 mg + 10 mg / kg / tsiku la mankhwalawa Augmentin ® pamiyeso itatu, ufa woyimitsidwa pakamwa. 125 mg + 31.25 mg mu 5 ml (156.25 mg).

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

• matenda apamwamba am'mapapo thirakiti (kuphatikiza matenda a ENT), monga kupezekanso kwa mamililitis, sinusitis, otitis media, omwe nthawi zambiri amayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae 1, Moraxella catarrhalis 1 ndi mapiritsi a Streptococcus, (kupatula mapiritsi a Augmentin 250 mg / 125 mg),
• kuchepa kwam'mimba thirakiti, monga kufalikira kwa chifuwa cham'mimba, chibayo ndi bronchopneumonia, yomwe nthawi zambiri imayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae 1 ndi Moraxella catarrhalis 1,
• matenda a kwamkodzo thirakiti, mwachitsanzo, cystitis, urethritis, pyelonephritis, matenda amchimayi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae 1 (makamaka Escherichia coli 1), Staphylococcus saprophyticus ndi Enterococcus, komanso gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae 1,
• matenda a pakhungu ndi zimakhala zofewa, zomwe nthawi zambiri zimayamba chifukwa cha Staphylococcus aureus 1, Streptococcus pyogene ndi mitundu ya mabakiteriya a genus 1,
• matenda a mafupa ndi mafupa, mwachitsanzo, osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus 1, ngati ndi kotheka, chithandizo cha nthawi yayitali ndizotheka.
• matenda a odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, mano owoneka kwambiri ndi kufalikira kwa cellulitis (piritsi la Augmentin piritsi, mlingo wa 500 mg / 125 mg, 875 mg / 125 mg),
• matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (piritsi la Augmentin piritsi limodzi ndi 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

Mimba komanso kuyamwa

Mu maphunziro a kubereka mu nyama, pakamwa komanso mwa uchembere wa Augmentin ® sizinayambitse zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matuza kusanachitike, anapezeka kuti mankhwala a prophylactic amatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis akhanda. Monga mankhwala onse, Augmentin® siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati, pokhapokha ngati phindu lomwe mayi akuyembekezera limaposa chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin® angagwiritsidwe ntchito poyamwitsa. Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amaphatikizidwa ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimachitika mu mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Zotsatira zoyipa

Matenda opatsirana komanso parasitic: Nthawi zambiri - candidiasis a pakhungu ndi mucous nembanemba.

Mbali ya magazi ndi zamitsempha yamagazi: kawirikawiri, kusintha kwa leukopenia (kuphatikizapo neutropenia) komanso kusintha kosinthika kwa magazi, osowa kwambiri, kusintha kwa agranulocytosis ndi kusintha kwa magazi kwa hemolytic, kuchuluka kwa nthawi ya prothrombin ndi nthawi ya magazi, kuchepa magazi, eosinophilia, thrombocytosis.

Kuchokera ku chitetezo chamthupi: kawirikawiri - angioedema, anaphylactic zimachitika, ndi matenda ofanana ndi seramu matenda, matupi a vasculitis.

Kuchokera ku dongosolo lamanjenje: pafupipafupi - chizungulire, kupweteka mutu, kawirikawiri - kusinthanso mphamvu, kupweteka (kupweteka kumachitika mwa odwala omwe ali ndi vuto laimpso, komanso kwa iwo omwe amalandira kuchuluka kwa mankhwala), kusowa tulo, kukhumudwa, nkhawa, kusintha kwa machitidwe.

Kuchokera pamimba yogaya: akulu: Nthawi zambiri - kutsegula m'mimba, kusanza, kusanza, ana - pafupipafupi - kutsegula m'mimba, kusanza, kusanza, anthu onse: nseru zimakonda kuchitika pakumwa mankhwala ambiri. Ngati mutayamba kumwa mankhwalawa pakakhala zovuta zina pamimba, amatha kutha ngati mumwa mankhwalawa koyambirira kwa chakudya. Nthawi zambiri - zovuta zakudya zam'mimba, kawirikawiri - ma colitis omwe amagwiritsidwa ntchito ndi ma antibayotiki omwe amayambitsidwa ndi kumwa ma antibayotiki (kuphatikizapo pseudomembranous colitis ndi hemorrhagic colitis), "lilime" lakuda, gastritis, stomatitis. Ana, mukamagwiritsa ntchito kuyimitsidwa, kusinthasintha kwa mawonekedwe a mano a enamel kumachitika kawirikawiri. Kusamalira pakamwa kumathandiza kuti musawononge mano a mano, chifukwa ndikokwanira kutsuka mano.

Pa mbali ya chiwindi ndi biliary thirakiti: pafupipafupi - kuwonjezeka kwapakati pa ntchito ya ACT ndi / kapena ALT (yowonetsedwa mwa odwala omwe amalandila beta-lactam antiotic mankhwala, koma tanthauzo lake lamatenda silikudziwika), kawirikawiri hepatitis ndi cholestatic jaundice (zochitika izi zimadziwika panthawi ya mankhwala a penicillin ndi cephalosporins), kuwonjezeka kwa kuchuluka kwa bilirubin ndi zamchere phosphatase. Zochitika zoyipa kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo amatha kuyanjana ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.

Zizindikiro zomwe zalembedwazo zimakonda kuchitika pakumala kapena atangomaliza kumene chithandizo, komabe nthawi zina mwina sangawonekere kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa. Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali anthu omwe anali ndi vuto lalitali kapena omwe amamwa nthawi yomweyo mankhwala a hepatotoxic.

Pa khungu ndi subcutaneous minofu: pafupipafupi - zidzolo, pruritus, urticaria, kawirikawiri erythema multiforme, kawirikawiri Stevens-Johnson syndrome, poyizoni epermatitis, poipa exfoliative dermatitis, pachimake kwambiri pantulosis.

Ngati khungu lanu siligwirizana, chithandizo ndi Augmentin® ziyenera kusiyidwa.

Kuchokera ku impso ndi kwamkodzo thirakiti: kawirikawiri - interstitial nephritis, crystalluria, hematuria.

Kuchita

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin® ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake, munthawi yomweyo kugwiritsa ntchito mankhwalawa Augmentin ® ndi phenenecide kungayambitse kuchuluka komanso kulimbikira kwamphamvu ya magazi a amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol. Penicillins amatha kuchepetsa mayankho a methotrexate kuchokera m'thupi popewa kubisalira kwake, chifukwa chake, kugwiritsa ntchito nthawi imodzi kwa Augmentin ® ndi methotrexate kungakulitse kuchuluka kwa methotrexate.

Monga mankhwala ena a antibacterial, Augmentin® ikhoza kukhudza microflora yamatumbo, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Mabukuwa amafotokoza zochitika zapafupipafupi za kuchuluka kwa anthu wamba mothandizirana ndi acenocoumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, makonzedwe omwewo a Augmentin ® pokonzekera ndi anticoagulants, nthawi ya prothrombin kapena MHO iyenera kuyang'aniridwa mosamala mukamayambitsa kapena kuletsa kukonzekera kwa Augmentin®; kusintha kwa antactagulants pakamwa kungafunike.

Momwe mungatenge, njira ya makonzedwe ndi kumwa

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin® imalimbikitsidwa kuti iziyamwa kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Akuluakulu ndi ana opitirira zaka 12 kapena masekeli 40 kapena kupitilira

Piritsi limodzi la 250 mg / 125 mg katatu / tsiku (la matenda ofatsa pang'ono kapena pang'ono), kapena piritsi limodzi la 500 mg / 125 mg katatu kapena tsiku, kapena piritsi limodzi la 875 mg / 125 mg katatu / tsiku, kapena 11 ml ya kuyimitsidwa kwa 400 mg / 57 mg / 5 ml 2 nthawi / tsiku (lofanana ndi piritsi limodzi la 875 mg / 125 mg).

Mapiritsi awiri a 250 mg / 125 mg siofanana ndi piritsi limodzi la 500 mg / 125 mg.

Ana kuyambira miyezi itatu mpaka 12 wazakudya zolemera thupi zosakwana 40 kg

Mankhwalawa adapangidwira mu mawonekedwe a kuyimitsidwa pakamwa.

Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mu mg / kg thupi / tsiku (kuwerengera malinga ndi amoxicillin) kapena ml ya kuyimitsidwa.

Kuchulukitsa kwa kuyimitsidwa kwa 125 mg / 31.25 mg mu 5 ml - katatu kapena tsiku lililonse maola 8 aliwonse

Kuchulukitsa kwa kuyimitsidwa 200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml - 2 kawiri / tsiku lililonse maola 12.

Mlingo woyeserera komanso kuchuluka kwa makonzedwe amaperekedwa pansipa:

Kuchulukitsa kuvomerezeka - katatu kapena tsiku, kuyimitsidwa 4: 1 (125 mg / 31.25 mg mu 5 ml):

• Mlingo wotsika - 20 mg / kg / tsiku.
• Mlingo waukulu - 40 mg / kg / tsiku.

Kuchulukana kwa makonzedwe - 2 nthawi / tsiku, kuyimitsidwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml):

• Mlingo wotsika - 25 mg / kg / tsiku.
• Mlingo waukulu - 45 mg / kg / tsiku.

Mlingo wocheperako wa Augmentin ® umagwiritsidwa ntchito pochiza matenda amkhungu ndi minyewa yofewa, komanso matendawa.

Mlingo waukulu wa Augmentin ® umagwiritsidwa ntchito pochiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma ndimatumbo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsa ntchito mankhwalawa Augmentin® muyezo wa 40 mg / kg / tsiku m'miyeso itatu yogawanika (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu

Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Kugwiritsa ntchito kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) sikulimbikitsidwa pagulu lino.

Ana asanakwane

Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Odwala okalamba

Palibe kusintha kwa mlingo komwe kumafunikira. Okalamba odwala mkhutu aimpso ntchito, mlingo uyenera kusinthidwa motere kwa akuluakulu omwe ali ndi vuto laimpso.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umachitika poganizira mfundo za QC.

Mapiritsi 250 mg + 125 mg kapena 500 mg + 125 mg:

• KK> 30 ml / min - kukonza kwa regimen sikofunikira.
• KK 10-30 ml / mphindi - 1 tabu. 250 mg + 125 mg 2 nthawi / tsiku kapena 1 tabu. 500 mg + 125 mg (kwa matenda ofatsa pang'ono) kawiri / tsiku.
• QC

Kuyimitsidwa 4: 1 (125 mg / 31.25 mg mu 5 ml):

• KK> 30 ml / min - kukonza kwa regimen sikofunikira.
• KK 10-30 ml / mphindi - 15 mg / 3.75 mg / kg 2 kawiri / tsiku, mlingo waukulu ndi 500 mg / 125 mg 2 nthawi / tsiku.
• QC

Mapiritsi a 875 mg + 125 mg ndi kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) akuyenera kugwiritsidwa ntchito mwa odwala CC> 30 ml / min, osasintha mlingo zofunika.

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa.

Odwala a hememalysis

Kusintha kwa mankhwalawa kutengera mlingo woyenera wa amoxicillin: 2 t. 250 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena 1 tabo. 500 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena kuyimitsidwa pa mlingo wa 15 mg / 3.75 mg / kg 1 nthawi / tsiku.

Mapale: panthawi ya hemodialysis gawo, muyeso 1 wa piritsi (piritsi limodzi) ndi 1 piritsi (piritsi limodzi) kumapeto kwa gawo la dialysis (kulipiritsa kuchepa kwa seramu yozungulira amo amoillin ndi clavulanic acid).

Kuyimitsidwa: isanachitike gawo la hemodialysis, mlingo umodzi wowonjezera wa 15 mg / 3.75 mg / kg uyenera kuperekedwa. Kubwezeretsa ndende ya magawo a mankhwala a Augmentin® m'magazi, muyeso wachiwiri wa 15 mg / 3.75 mg / kg uyenera kuyambitsidwa pambuyo pa gawo la hemodialysis.

Odwala omwe ali ndi vuto la chiwindi

Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti ikonzere kuchuluka kwa odwala mu gulu ili.

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Kuyimitsidwa (125 mg / 31.25 mg mu 5 ml): pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afunditse kutentha kwa chipinda akuyenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivundikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti onetsetsani kuswana kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa kukonzekera kwa Augmentin® ukhoza kuchepetsedwa pakati ndi madzi.

Kuyimitsidwa (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml): onjezani pafupifupi 40 ml ya madzi owiritsa ozizira kuti asungunuke m'chipinda cha botolo la ufa, ndiye kutseka kapu ya botolo ndikugwedezeka mpaka ufa utatha Lolani vial kuyimirira kwa mphindi 5 kuti muwonetsetsetsetsetse kuti mwatsuka. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 64 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwalawa, gwiritsani ntchito kapu kapena syringe yoyenera, yomwe imayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana ochepera zaka ziwiri, muyezo umodzi wokha wa kuyimitsidwa kwa kukonzekera kwa Augmentin® akhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Bongo

Zizindikiro: Zizindikiro zam'mimba komanso kusowa kwa madzi m'magetsi kumatha kuchitika. Amoxicillin crystalluria akufotokozedwa, nthawi zina kumabweretsa kukula kwa aimpso.

Convulsions amatha kuchitika kwa odwala mkhutu aimpso ntchito, komanso kwa iwo omwe amalandira kuchuluka kwa mankhwalawa.

Chithandizo: Zizindikiro zam'mimba - chidziwitso cha mankhwala, kulabadira makamaka kutulutsa bwino zamagetsi am'madzi. Ngati bongo, amoxicillin ndi clavulanic acid amatha kuchotsedwa m'magazi ndi hemodialysis.

Zotsatira za kafukufuku woyembekezeredwa yemwe adachitika ndi ana 51 kumalo operekera poizoni adawonetsa kuti kuyang'anira amoxicillin pamlingo wochepera 250 mg / kg sizinachititse kuti pakhale ndi zidziwitso zazikulu zakuchipatala ndipo sizinafune kuti pakhale chiphuphu.

Malangizo apadera

Musanayambe chithandizo ndi Augmentin ®, ndikofunikira kusaka mbiri yakale yokhudzana ndi zam'mbuyomu zomwe zimapangitsa kuti penicillins, cephalosporins kapena allergen ena azigwira.

Zowopsa, ndipo nthawi zina zakupha, hypersensitivity reaction (anaphylactic reaction) ku penicillins amafotokozedwa. Chiwopsezo chotere chimakhala chokwanira kwambiri kwa odwala omwe ali ndi mbiri ya hypersensitivity reaction ku penicillins. Ngati thupi siligwirizana, ndikofunikira kusiya mankhwala ndi Augmentin ® ndikuyamba njira zina zoyenera. Pankhani ya vuto lalikulu la hypersensitivity, epinephrine iyenera kutumikiridwa nthawi yomweyo. Thandizo la okosijeni, iv makonzedwe a GCS ndi kuperekedwa kwa airway patency, kuphatikizapo intubation, ingafunikenso.

Kukhazikitsidwa kwa mankhwalawa Augmentin® sikulimbikitsidwa pa milandu ya mononukpeosis yemwe akuwoneka kuti ali ndi vuto, chifukwa odwala omwe ali ndi matendawa amoxillin amatha kuyambitsa matenda opatsirana ngati chikuku, omwe amachititsa kuti azindikire matendawa.

Kuchiza kwa nthawi yayitali ndi Augmentin® nthawi zina kumabweretsa kubalanso kwakukulu kwa tizilombo tating'onoting'ono.

Mwambiri, Augmentin® imalekeredwa bwino ndipo ili ndi poizoni wambiri wa ma penicillin onse.

Pa chithandizo cha nthawi yayitali ndi Augmentin®, tikulimbikitsidwa kuti nthawi ndi nthawi tiziona ntchito ya impso, chiwindi ndi magazi.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya.

Odwala omwe amalandila amoxicillin ndi clavulanic acid limodzi ndi ma anticoagulants osalunjika, nthawi zina, kuchuluka kwa prothrombin nthawi (kuwonjezeka kwa MHO) kunanenedwa. Ndi kuphatikiza molunjika kwa anticoagulants osalunjika (pakamwa) osakanikirana a amoxicillin ndi clavulanic acid, kuyang'anira zisonyezo ndikofunikira. Kusungitsa kufunika kwa anticoagulants pakamwa, kusintha kwa mlingo kungafunike.

Odwala omwe ali ndi vuto la impso, mlingo wa Augmentin® uyenera kuchepetsedwa molingana ndi kufooka.

Odwala ndi kuchepetsedwa diuresis, nthawi zina, chitukuko cha crystalluria chimanenedwa, makamaka ndi kugwiritsidwa ntchito kwa mankhwala ndi ababa. Munthawi ya makonzedwe apamwamba a amoxicillin, tikulimbikitsidwa kuti timwe madzi okwanira ndikukhala ndi diursis yokwanira kuti muchepetse mapangidwe a makhwala a amoxicillin.

Kumwa mankhwalawa Augmentin ® mkati kumabweretsa zambiri mu amoxicillin mu mkodzo, zomwe zingayambitse zotsatira zabodza pakutsimikiza kwa shuga mumkodzo (mwachitsanzo, mayeso a Benedict, mayeso a Fel). Poterepa, tikulimbikitsidwa kugwiritsa ntchito njira ya glucose oxidant pofufuza kuchuluka kwa shuga mumkodzo.

Kusamalira pakamwa kumathandiza kuti mano asatulutsidwe, popeza kutsuka mano ndikokwanira.

Mapiritsi ayenera kugwiritsidwa ntchito mkati mwa masiku 30 kuyambira pomwe mutsegule phukusi la lameled aluminium.

Kuzunza ndi kudalira mankhwala osokoneza bongo

Palibe kudalira mankhwala, mankhwala osokoneza bongo komanso kusinthasintha kwakukhudzana ndi kugwiritsa ntchito mankhwalawa Augmentin®.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Popeza mankhwalawa angayambitse chizungulire, ndikofunikira kuchenjeza odwala za kusamala poyendetsa kapena kugwiritsa ntchito makina osunthira.

Momwe mungagwiritsire ntchito mankhwala a Augmentin 625?

Semi-kupanga mankhwala a penicillin gulu lochitapo kanthu Augmentin 625 amagwiritsidwa ntchito pofuna kuchiza zotupa mu thupi.Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amayankha chithandizo. Mankhwalawa amagwiritsidwa ntchito kuti awononge mawonekedwe osakanikirana omwe amayimiriridwa ndi mabakiteriya ndi ma virus. Zamoyo zina zimaberekanso lactamases, zimayamba kukana maantibayotiki. Amoxicillin osakanikirana ndi clavulanic acid amachepetsa kukana kwawo.

Beta-lactams ndi mankhwala antibacterial pakugwiritsa ntchito mwadongosolo ndipo ndi ophatikiza a owononga a beta-lactamase ndi penicillin. Code J01C R02.

Semi-kupanga mankhwala a penicillin gulu lochitapo kanthu Augmentin 625 amagwiritsidwa ntchito pofuna kuchiza zotupa mu thupi.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala osokoneza bongo a 650 (500 mg + 125 mg) amapezeka mwa zoyera kapena pang'ono ndi mapiritsi amitundu. Pa chipolopolo pali mawu olembedwa AC, mbali imodzi ndi notch. Zidutswa 7 zimayikidwa m'mbale zojambulazo, zomwe 2 zimadzaza pabokosi. Poda yomwe ili mgululi siyikupezeka ngati kuyimitsidwa.

• amoxicillin imaperekedwa ngati madzi am'madzi, ili ndi 500 mg,
• clavulanate imaphatikizidwa mu kuchuluka kwa 125 mg.

Pharmacokinetics

Zinthu zonsezi zimatsitsidwa pakamwa pakamwa, phindu lawo la bioavailability lili pa 70%. Nthawi yowonetsera pazambiri zomwe zili m'madzi a m'magazi ndi ola limodzi. Masautso a plasma mukamagwiritsa ntchito kuphatikiza kwa Augmentin ndi ofanana, ngati kuti amamwa amoxicillin ndi clavulanate payokha.

Kotala yonse ya clavulanate imalumikizana ndi mapuloteni, amoxicillin imamanga 18%. Mu thupi, zinthu zimagawidwa potengera:

• agntibiotic - 0,31 - 0,41 L pa kilogalamu ya thupi,
• asidi - 0,21 l pa kilogalamu ya misa.

Pambuyo pa makonzedwe, zonse ziwiri zimapezeka mu peritoneum, mafuta wosanjikiza, chikhodzodzo cha ndulu, bile, minofu, ascites ndi fluid fluid. Amoxicillin sapezeka mu madzi am'madzi, koma amalowa mkaka wa mzimayi kudzera mu placenta. M'matipi amthupi, zinthu ndi zomwe zimachokera sizimadziunjikira.

Amoxicillin amachoka mu mawonekedwe a ricinoleic acid mu gawo la kotala la gawo loyambirira kudzera mu kwamikodzo. Clavulanate ndi 75-85% imapangidwa m'thupi ndipo imachoka m'thupi ndi ndowe, mkodzo, wothothidwa m'mapapu ndi mpweya mu mawonekedwe a mpweya woipa.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amagwiritsidwa ntchito pochizira zotsatira za othandizira Augmentin. Mankhwalawa amagwiritsidwa ntchito pochiza:

• zotupa za mucous wosanjikiza wa sinus, zosokonezeka pambuyo chimfine, mphuno zamkati, kuvulala kumaso,
• kutupa mkati mwa khutu,
• pachimake mawonekedwe a bronchitis
• chibayo chomwe chikukula kunja kwa chipatala,
• kutupa kwa makoma a chikhodzodzo,
• kuwonongeka kwa dongosolo la impso,
• matenda a minofu, minofu ndi khungu pakhungu pambuyo kulumidwa kwa nyama zosiyanasiyana,
• kuwonongeka kwa minofu ndi zida zozungulira mano,
• mafupa ndi matenda olowa.

Mapale, okhala ndi utoto wambiri kuyambira oyera mpaka oyera, amakhala owunda, pomwe mawu akuti "AUGMENTIN" adakanikizidwa mbali imodzi, pakhungu, kuyambira yoyera mpaka yoyera.

Ma PC 10 - matuza (1) ndi thumba la silika gel osakaniza - ma CD opangidwa ndi lamoni aluminiyamu zojambulazo (2) - mapaketi a makatoni.

Mapiritsi, omwe amaphatikizidwa ndi filimu kuyambira oyera mpaka pafupi oyera, amakhala ozungulira, ali ndi mawu oti "AC" komanso omwe ali pachiwopsezo mbali imodzi.

Omwe amathandizira: magnesium stearate - 7.27 mg, sodium carboxymethyl - 21 mg, colloidal silicon dioxide - 10,5 mg, microcrystalline cellulose - mpaka 1050 mg.

7 ma PC - matuza (1) ndi thumba la silika gel osakaniza - ma CD opangidwa ndi lamoni aluminiyamu zojambulazo (2) - mapaketi a makatoni.
Ma PC 10 - matuza (1) ndi thumba la silika gel osakaniza - ma CD opangidwa ndi lamoni aluminiyamu zojambulazo (2) - mapaketi a makatoni.

Mapiritsi, okhala ndi utoto wambiri kuyambira oyera mpaka oyera, ali ndi zotupa, ndipo zilembo "A" ndi "C" mbali zonse ziwiri za phale ndi mzere wolakwika mbali imodzi, pamphaka - kuyambira kuyera mpaka kutuwa.

Omwe amathandizira: magnesium stearate - 14,5 mg, sodium carboxymethyl - 29 mg, colloidal silicon dioxide - 10 mg, cellcrystalline cellulose - 396,5 mg.

7 ma PC - matuza (1) ndi thumba la silika gel osakaniza - ma CD opangidwa ndi lamoni aluminiyamu zojambulazo (2) - mapaketi a makatoni.

Ufa pakukonzekera kuyimitsidwa kwa pakamwa yoyera kapena yoyera, yokhala ndi fungo labwino, ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi kuyera kumapangidwa, kuyimirira, kuyimira koyera kapena pafupifupi koyera kumapangidwa pang'onopang'ono.

11.5 g - mabotolo agalasi (1) okwanira ndi kapu yoyezera - mapaketi a makatoni.

Ufa pakukonzekera kuyimitsidwa kwa pakamwa yoyera kapena yoyera, yokhala ndi fungo labwino, ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi kuyera kumapangidwa, kuyimirira, kuyimira koyera kapena pafupifupi koyera kumapangidwa pang'onopang'ono.

7.7 g - mabotolo agalasi (1) okwanira ndi kapu yoyezera - mapaketi a makatoni.

Ufa pakukonzekera kuyimitsidwa kwa pakamwa yoyera kapena yoyera, yokhala ndi fungo labwino, ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi kuyera kumapangidwa, kuyimirira, kuyimira koyera kapena pafupifupi koyera kumapangidwa pang'onopang'ono.

12,6 g - mabotolo agalasi (1) okwanira ndi kapu yoyezera - mapaketi a makatoni.

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi β-lactamases, chifukwa chake zochitika za amoxicillin sizingofikira ku tizilombo tating'onoting'ono timene timatulutsa enzymeyi.

Clavulanic acid, β-lactamase inhibitor yokhudzana ndi penicillin, amatha kupanga ma act lactamase osiyanasiyana opezeka mu penicillin ndi cephalosporin zosagwira tizilombo.

Clavulanic acid imagwira mokwanira motsutsana ndi plasmid β-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal β-lactamases ya mtundu 1 yomwe sikuletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu kukonzekera kwa Augmentin kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - β-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Otsatirawa ndi ntchito ya vitro yosakanikirana ya amoxicillin ndi clavulanic acid.

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Ma gror-positive aerobes: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus pyogene 1,2, Streptococcus agalactiae 1,2, Streptococcus spp. (beta hemolytic streptococci) 1,2, Staphylococcus aureus (wokhudzidwa ndi methicillin) 1, Staphylococcus saprophyticus (wogwira methicillin), Staphylococcus spp. (coagulase-hasi, amakhudzidwa ndi methicillin).

Ma grram-negative aerobes: Bordetella pertussis, Haemophilus fuluwenza 1, Helicobacter pylori, Moraxella catarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Enanso: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Ma anaerobes a gram-positive: Clostridium spp., Peptococcus niger, Peptostreptococcus magnus, Peptostreptococcus micros, Peptostreptococcus spp.

Gram-negative anaerobes: Bacteroides fragilis, Bacteroides spp., Capnocytophaga spp., Eikenella corrodens, Fusobacterium nucleatum, Fusobacterium spp., Porphyromonas spp., Prevotella spp.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Gram-negative aerobes: Escherichia coli 1, Klebsiella oxytoca, Klebsiella pneumoniae 1, Klebsiella spp., Proteus mirabilis, Proteus vulgaris, Proteus spp., Salmonella spp., Shigella spp.

Ma gror-positive aerobes: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2, Streptococcus group Viridans 2.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-hasi aerobes: Acinetobacter spp.

Ena: Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia spp., Coxiella burnetti, Mycoplasma spp.

1 - mwa mitundu iyi ya tizilombo tating'onoting'ono, kufunikira kwa zamankhwala kosakanikirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 - mitundu ya mabakiteriya amtunduwu samatulutsa β-lactamases. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Zonsezi zigawo zogwiritsidwa ntchito ndi mankhwalawa Augmentin, amoxicillin ndi clavulanic acid, zimatulutsa mwachangu komanso kwathunthu kuchokera m'mimba thirakiti pambuyo pakamwa. Kuyamwa kwa yogwira zinthu ndi mulingo woyenera kumwa mankhwala kumayambiriro kwa chakudya.

Mapiritsi Augmentin 250 mg / 125 mg (375 mg), Augmentin 250 mg / 125 mg (375 mg), Augmentin 500 mg / 125 mg (625 mg), Augmentin 875 mg / 125 mg (1000 mg)

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid, omwe amapezeka mu maphunziro osiyanasiyana, pomwe odzipereka athanzi adatenga mimba yopanda kanthu, akuwonetsedwa pansipa:

- piritsi limodzi la mankhwala Augmentin 250 mg / 125 mg (375 mg),

- mapiritsi 2 a mankhwala a Augmentin 250 mg / 125 mg (375 mg),

- piritsi limodzi la mankhwala Augmentin 500 mg / 125 mg (625 mg),

- 500 mg wa amoxicillin,

- 125 mg ya clavulanic acid,

- mapiritsi 2 a mankhwala a Augmentin 875 mg / 125 mg (1000 mg)

Magawo akuluakulu a pharmacokinetic amaperekedwa pagome.

Mukamagwiritsa ntchito Augmentin, kuchuluka kwa plasma kwa amoxicillin ndi ofanana ndi kamvekedwe kamilingo ya amoxicillin chimodzimodzi.

Augmentin 125 mg / 31.25 mg pa 5 ml ya kuyimitsidwa kwamlomo

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga 40 mg / 10 mg / kg thupi / tsiku la mankhwala a Augmentin, ufa kuti ayimitsidwe pakamwa mu 3 Mlingo. 125 mg / 31.25 mg mu 5 ml (156.25 mg).

Magawo akuluakulu a pharmacokinetic.

Ufa woyimitsidwa pakamwa makonzedwe a Augmentin 200 mg / 28,5 mg mu 5 ml

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga mankhwala a Augmentin, ufa woyimitsidwa pakamwa, 200 mg / 28,5 mg mu 5 ml (228,5 mg) mu. Mlingo wa 45 mg / 6,4 mg / kg / tsiku, logawidwa pawiri.

Magawo a pharmacokinetic oyambira

Ufa woyimitsidwa pakamwa makonzedwe a Augmentin 400 mg / 57 mg mu 5 ml

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi atatenga mlingo umodzi wa Augmentin, ufa kuti ayimitse pakamwa, 400 mg / 57 mg mu 5 ml (457 mg).

Magawo a pharmacokinetic oyambira

Zochizira zozungulira amo amoillillin ndi clavulanic acid zimapangidwa mu ziwalo zosiyanasiyana ndi minyewa, mkati mwa madzi (ziwalo zam'mimba, adipose, mafupa ndi minofu minofu, zotumphukira ndi zotumphukira zamkati, khungu, bile, kutulutsa kwatsopano).

Amoxicillin ndi clavulanic acid ali ndi malire ofooka a mapuloteni a plasma. Kafukufuku wasonyeza kuti 25% ya kuchuluka kwathunthu kwa clavulanic acid ndi 18% ya amoxicillin imamangiriza mapuloteni am'madzi.

Mu maphunziro a zinyama, kuwerengetsa kwa zosakaniza za Augmentin ya mankhwala sikunapezeke.

Amoxicillin, monga ma penicillin ambiri, amadutsa mkaka wa m'mawere. Zotsatira za clavulanic acid zapezekanso mkaka wa m'mawere. Kafukufuku wokhudzana ndi kubereka mu zinyama adawonetsa kuti amoxicillin ndi clavulanic acid amawoloka chotchinga, popanda zizindikilo za zovuta pa mwana wosabadwayo.

10-25% ya mlingo woyambirira wa amoxicillin amuchotseredwa ndi impso ngati yogwira metabolite (penicilloic acid). Clavulanic acid imapangidwa modabwitsa kwambiri mpaka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-1H-pyrrole-3-carboxylic acid ndi 1-amino-4-hydroxy-butan-2-imodzi ndipo imayesedwa ndi impso. kudzera m'mimba, komanso ndi mpweya wotha ntchito mu mpweya wa kaboni.

Monga ma penicillin ena, amoxicillin amathandizidwa ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso komanso owonjezera.Kafukufuku akuwonetsa kuti, pafupifupi, pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amawachotsa impso osasinthika maola 6 atangotenga piritsi limodzi la 250 mg / 125 mg kapena piritsi limodzi la 500 mg / 125 mg.

Bacteria matenda oyambitsidwa ndi tizilombo tating'ono ta mankhwala:

Zofooka zam'mimba zopumira komanso ziwalo za ENT (mwachitsanzo, tenillitisitis, sinusitis, atitis media), zomwe nthawi zambiri zimayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogene,

- kupweteka kwam'mimba thirakiti: kukokoloka kwa chifuwa cham'mimba, chibayo ndi bronchopneumonia, yomwe nthawi zambiri imayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae * ndi Moraxella catarrhalis * (kupatula mapiritsi 250 mg / 125 mg),

Matenda a urogenital thirakiti: cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli *), Staphylococcus saprophyticus ndi mitundu ya genoc Enterococcus,

- gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae * (kupatula mapiritsi 250 mg / 125 mg),

- Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, Streptococcus pyogene ndi mitundu ya mtundu wa Bacteroides *,

- matenda am'mafupa ndi mafupa: osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, ngati kuli kotheka, chithandizo cha nthawi yayitali,

- matenda a odontogenic, mwachitsanzo, periodontitis, maxillary sinusitis, zotupa zamano kwambiri ndi kufalitsa cellulite (mapiritsi 500 mg / 125 mg kapena 875 mg / 125 mg),

- matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg).

- - Oimira pawokha a mtundu wina wa tizilombo tating'onoting'ono timatulutsa β-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin.

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Augmentin amasonyezedwanso ntchito yochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa β-lactamase, omvera kuphatikizidwa kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

- Hypersensitivity to amoxicillin, clavulanic acid, magawo ena a mankhwala, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,

- magawo am'mbuyomu a jaundice kapena chiwindi chovutikira mukamagwiritsa ntchito mankhwala osakanikirana a amoxicillin ndi clavulanic acid mu anamnesis,

- ana a zaka mpaka 12 ndi kulemera kwa thupi kosakwana 40 kg (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg),

- ana a zaka mpaka miyezi itatu (ufa wopangira kuyimitsidwa kwa makonzedwe amkamwa a 200 mg / 28,5 mg ndi 400 mg / 57 mg),

- kuwonongeka kwaimpso (CC ≤ 30 ml / mphindi) - (mapiritsi 875 mg / 125 mg, pa ufa w kuyimitsidwa pakumwa kwamlomo 200 mg / 28,5 mg ndi 400 mg / 57 mg),

- phenylketonuria (ufa wowimitsa pakumwa pakamwa).

Chenjezo: Kuwonongeka kwa chiwindi.

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin akulimbikitsidwa kuti idzatenge kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Akuluakulu ndi ana opitirira zaka 12 kapena masekeli 40 kapena kupitilira

Piritsi limodzi la 250 mg / 125 mg katatu / tsiku (la matenda ofatsa pang'ono kapena pang'ono), kapena piritsi limodzi la 500 mg / 125 mg katatu kapena tsiku, kapena piritsi limodzi la 875 mg / 125 mg katatu / tsiku, kapena 11 ml ya kuyimitsidwa kwa 400 mg / 57 mg / 5 ml 2 nthawi / tsiku (lofanana ndi piritsi limodzi la 875 mg / 125 mg).

Mapiritsi awiri a 250 mg / 125 mg siofanana ndi piritsi limodzi la 500 mg / 125 mg.

Ana kuyambira miyezi itatu mpaka 12 wazakudya zolemera thupi zosakwana 40 kg

Mankhwalawa adapangidwira mu mawonekedwe a kuyimitsidwa pakamwa.

Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mu mg / kg thupi / tsiku (kuwerengera malinga ndi amoxicillin) kapena ml ya kuyimitsidwa.

Kuchulukitsa kwa kuyimitsidwa kwa 125 mg / 31.25 mg mu 5 ml ndi katatu kapena tsiku lililonse maola 8 aliwonse.

Kuchulukitsa kwa kuyimitsidwa 200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml - 2 kawiri / tsiku lililonse maola 12.

Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Mlingo wa Augmentin patebulo la mankhwalawa

Mlingo wocheperako wa Augmentin amagwiritsidwa ntchito pochiza matenda amkhungu komanso minyewa yofewa, komanso matendawa.

Mlingo waukulu wa Augmentin amagwiritsidwa ntchito pochiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma ndimatumbo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsidwa ntchito kwa mankhwalawa Augmentin muyezo woposa 40 mg / kg / tsiku mu 3-mgawo wogawanika (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu

Chifukwa cha kusakhazikika kwa mawonekedwe a impso, njira yolimbikitsidwa ya Augmentin (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2-mgulu wogawika mu mawonekedwe a kuyimitsidwa kwa 4: 1.

Kugwiritsa ntchito kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) sikulimbikitsidwa pagulu lino.

Ana asanakwane

Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Odwala okalamba

Palibe kusintha kwa mlingo komwe kumafunikira. Okalamba odwala mkhutu aimpso ntchito, mlingo uyenera kusinthidwa motere kwa akuluakulu omwe ali ndi vuto laimpso.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umachitika poganizira mfundo za QC.

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa.

Odwala a hememalysis

Kusintha kwa mankhwalawa kutengera mlingo woyenera wa amoxicillin: 2 t. 250 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena 1 tabo. 500 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena kuyimitsidwa pa mlingo wa 15 mg / 3.75 mg / kg 1 nthawi / tsiku.

Mapale: panthawi ya hemodialysis gawo, muyeso 1 wa piritsi (piritsi limodzi) ndi 1 piritsi (piritsi limodzi) kumapeto kwa gawo la dialysis (kulipiritsa kuchepa kwa seramu yozungulira amo amoillin ndi clavulanic acid).

Kuyimitsidwa: isanachitike gawo la hemodialysis, mlingo umodzi wowonjezera wa 15 mg / 3.75 mg / kg uyenera kuperekedwa. Kubwezeretsa ndende ya yogwira mankhwala a Augmentin m'magazi, yachiwiri mlingo wa 15 mg / 3.75 mg / kg uyenera kuperekedwa pambuyo pa gawo la hemodialysis.

Odwala omwe ali ndi vuto la chiwindi

Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti ikonzere kuchuluka kwa odwala mu gulu ili.

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Kuyimitsidwa (125 mg / 31.25 mg mu 5 ml): pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afunditse kutentha kwa chipinda akuyenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utatha, lolani botolo kuti liyime kwa mphindi 5 kuti zitsimikizire kuti zonse kuswana. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin akhoza kuchepetsedwa pakati ndi madzi.

Kuyimitsidwa (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml): onjezani pafupifupi 40 ml ya madzi owiritsa ozizira kuti asungunuke m'chipinda cha botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utatha. imirirani kwamphindi kwa mphindi 5 kuti muwonetsetsetsetsetsetsetsetsetsetse kuti mwakonzeka. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 64 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwalawa, gwiritsani ntchito kapu kapena syringe yoyenera, yomwe imayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin akhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Zochitika zoyipa zomwe zaperekedwa pansipa zalembedwa malinga ndi kuwonongeka kwa ziwalo ndi ziwalo zamagulu ndi pafupipafupi zomwe zimachitika. Pafupipafupi zomwe zimachitika zimatsimikiziridwa motere: Nthawi zambiri (≥1 / 10), nthawi zambiri (≥1 / 100, 30 ml / min

Augmentin 625 - njira yothandiza ya matenda a prostatitis

Pochiritsira matenda ambiri opatsirana omwe amakhudza akulu ndi ana, mankhwalawa Augmentin (dzina lina lamalonda ndi Amoxiclav) amagwiritsidwa ntchito. Chifukwa chogwira ntchito kwambiri, mankhwalawa nthawi zambiri amaperekedwa ndi madokotala osiyanasiyana. Zinthu zomwe zimaphatikizidwa ndi maantibayotiki ophatikizana zimawononga mabakiteriya amtundu wa pathogenic, kuletsa kapangidwe ka makoma a maselo awo.

Mawonekedwe a anatomical ndi achire gulu mankhwala: J01CR02.

Zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala ophatikizira a Augmentin zimawononga mabakiteriya okhala ndi tizilomboti, kuteteza kaphatikizidwe kazenera ka maselo awo.

2 Mawonekedwe ake ndi mitundu

Augmentin amaphatikiza zinthu ziwiri zogwira ntchito: amoxicillin (Amoxicillin) ndi clavulanic acid (clavulanic acid). Amoxicillin ali pamndandanda wa mankhwala ofunikira omwe amapangidwa ndi WHO.

Mitundu ya yotulutsa maantiotic:

• Mapiritsi a Augmentin 375 mg, 625 mg ndi 1000 mg,
• ufa wothira mafuta, pomwe kuyimitsidwa pakamwa kapena njira yothetsera jakisoni (kokha mtsempha).

Piritsi limodzi la Augmentin 625 lili ndi 500 mg ya amoxicillin trihydrate ndi 125 mg ya potaziyamu clavulanate.

• pawiri wowuma ndi sodium,
• silicon dioxide
• magnesium wakuba,
• microcrystalline mapadi.

Augmentin imapezeka mu ufa wophatikizira, kuchokera komwe kuyimitsidwa kumakonzekera kukonzekera pakamwa.

Mapiritsiwo ali ndi chipolopolo, chomwe chimaphatikizapo:

• hypromellose (polima),
• dimethicone (silicone),
• titanium dioxide (utoto woyera),
• macrogol (mankhwala ofewetsa thukuta).

Kuyika Augmentin 625: 7 kapena 10 zidutswa mu aluminiyumu zojambulazo, matuza 1 kapena 2 mu bokosi la makatoni okhala ndi mawonekedwe a silika gel osakaniza.

6 Momwe mungatenge Augmentin 625

Pofuna kuti mankhwalawo amwe kwambiri komanso kuti azitha kuchepetsedwa, wopanga amalimbikitsa kugwiritsa ntchito mapiritsi kumayambiriro kwa chakudya. Mlingo amasankhidwa poganizira mtundu, kuuma kwa matenda, zaka, kulemera ndi momwe impso za wodwalayo zilili. Mlingo wocheperako wa Augmentin amapatsidwa mankhwala opatsirana mwa mabakiteriya ofewa, khungu, tonsillitis komanso pafupipafupi. Mlingo woyenera ayenera kuchitira sinusitis, otitis media, matenda am'mapapu, pleura, mafupa, ndi kwamikodzo dongosolo.

Ndi matenda olimbitsa thupi, achikulire ndi achinyamata opitirira zaka 12 nthawi zambiri amapatsidwa kumwa piritsi limodzi la 375 mg katatu pa tsiku, ndipo pamavuto akulu, 1 piritsi 625 mg. Tiyenera kukumbukira kuti piritsi limodzi la Augmentin 625 mg silofanana ndi mapiritsi 2 a 375 mg. Kusintha kuchokera ku njira ya jakisoni popereka mankhwalawa kumapiritsi kumachitika.

Kwa ana ochepera zaka 12, mankhwalawa ali ngati mawonekedwe a madzi (amakonzedwa kuchokera ku ufa). Mlingo umodzi wa maantibayotiki omwe amaperekedwa kwa mwana katatu patsiku amawerengedwa potengera zaka zake:

• Miyezi 9 - zaka 2: 62.5 mg,
• Zaka 2-7: 125 mg,
• Zaka 7-12: 250 mg.

Mlingo wovomerezeka wa 4: 1 kuyimitsidwa kwa ana kuyambira miyezi 1 mpaka 3 ndi 30 mg (kwa amoxicillin) pa kilogalamu imodzi ya kulemera, yomwe imaperekedwa Mlingo 2 wogawanika. Zoyesa zamankhwala ndizosakwanira kudziwa kuchuluka kwa 40 mg + 10 mg / kg pazigawo zitatu za ana osaposa zaka ziwiri.

Kutalika kwa chithandizo ndi Augmentin kuyambira masiku 5 mpaka 14.

Posankha mankhwala, ndikofunikira kuganizira ngati wodwalayo ali pachiwopsezo. Izi ndi:

1. Odwala ndi mkhutu aimpso ntchito. Mlingo waukulu wa antibayotiki tikulimbikitsidwa kupatsidwa chilolezo cha creatinine. Mankhwalawa amaperekedwa bwino kwambiri.
2. Odwala omwe ali ndi matenda a chiwindi. Kuwunikira kwakanthawi mkhalidwe wa chiwalo ndikofunikira.
3. Anthu okalamba. Kusintha kwa Mlingo sikofunikira ngati palibe matenda a impso ndi chiwindi.
4. Odwala omwe amafunikira hemodialysis. Mlingo woyenera: piritsi limodzi la Augmentin 625 mg tsiku lililonse. Kuphatikiza apo: isanachitike ndi itatha - piritsi 1.

Okalamba safuna kusintha kwa mankhwalawa ngati palibe matenda a impso ndi chiwindi.

Malangizo apadera

Musanayambe mankhwala opha maantibayotiki, ndikofunikira kudziwa ngati wodwalayo adakumana ndi zovuta za penicillin kapena cephalosporins. Zolemba za anaphylactic mantha ndizosowa kwambiri. Ngati zizindikiro za hypersensitivity to penicillin zikuwoneka, maantibayotiki ayenera kuyimitsidwa yomweyo. Epinephrine ndi jakisoni wa corticosteroids, kuchepa kwa okosijeni (masisitimu okumba a thupi ndi mpweya), intubation (kukulitsa kwa trachea kuti abwezeretse kupuma) amathandizira kuchotsa wodwalayo pamavuto akulu.

Ndi makonzedwe omwewo a Augmentin omwe ali ndi mankhwala opha antagagant mapiritsi, nthawi zina zimakhala zofunikira kuti awonjezere kuchuluka kwake kuti akwaniritse zomwe akuyembekeza.

Kugwiritsa ntchito mankhwala kwa nthawi yayitali, makamaka pamlingo waukulu, nthawi zambiri kumayambitsa kukula kwa dysbiosis, kuphwanya kwa kayendedwe ka hematopoietic system ndi impso. Ngati creatinine chilolezo chimakhala chochepera 30 ml / mphindi, mapiritsi a Augmentin okha 625 mg ndi 375 mg, kuyimitsidwa kwa 125 + 31.25 mg, mayankho a jakisoni 500 + 100 mg ndi 1000 + 200 mg amaloledwa.

Ngati mukukayikira mononucleosis wa bakiteriya, simuyenera kupereka mankhwala, chifukwa amoxicillin nthawi zambiri amayambitsa zotupa pakhungu. Chizindikiro choterechi chimatha kupangitsa kuti muzindikire zabodza.

Pochita ndi Mlingo waukulu wa antibayotiki, munthu amamwa kwambiri kuti mupewe kukokoloka kwa chikhodzodzo. Kugwiritsa ntchito kwambiri kwamkodzo mumkodzo kungayambitse kuyesedwa kwa shuga kwamkodzo. Ndikulimbikitsidwa kuti kuyeserera kwa labotale kuchitike pogwiritsa ntchito njira ya glucose oxidant.

Chizindikiro chogwiritsidwa ntchito

Bacteria matenda oyambitsidwa ndi tizilombo tating'ono ta mankhwala:

• matenda a kumtunda kwa kupuma thirakiti ndi ziwalo za ENT (mwachitsanzo, tenillitisitis, sinusitis, atitis media), zomwe nthawi zambiri zimayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogene,
• matenda apumidwe am'mimba thirakiti: kukokoloka kwa chifuwa cham'mimba, chibayo ndi bronchopneumonia, yomwe nthawi zambiri imayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae ndi Moraxella catarrhalis (kupatula mapiritsi 250 mg / 125 mg),
• matenda a kwamkodzo thirakiti: cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli *), Staphylococcus saprophyticus ndi mitundu ya mtundu wa Enterococcus,
• chinzonono chifukwa cha Neisseria gonorrhoeae (kupatula mapiritsi a 250 mg / 125 mg),
• matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, Streptococcus pyogene ndi mitundu ya mtundu wa Bactero> Mlingo ndi makonzedwe

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin akulimbikitsidwa kuti idzatenge kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Contraindication

• hypersensitivity to amoxicillin, clavulanic acid, zinthu zina za mankhwalawa, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,
• magawo am'mbuyomu a jaundice kapena chiwindi chovuta kugwiritsa ntchito pophatikiza amoxicillin wokhala ndi clavulanic acid m'mbiri
• ana ochepera zaka 12 ndi kulemera kwa thupi zosakwana 40 kg

Malo osungira

Mankhwalawa amayenera kusungidwa kuti ana asawatenthe pa kutentha osaposa 25 ° C.

M'modzi piritsi yamlomo ili ndi 0,25, 0,5 kapena 0,875 g amoxicillin trihydrate ndi 0,125 g clavulanic acid (popanga mankhwalawa, sodium clavulanate imayikidwa ndi 5% yowonjezera).

Kuphatikizidwa ndi piritsi zothandizira: Silicii dioxydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Botolo limodzi ufa wokonzekera njira jakisoni ali ndi 0,5 kapena 1 g amoxicillin trihydrate ndipo, motero, 0,1 kapena 0,2 g clavulanic acid.

The zikuchokera Augmentin ufa woyimitsidwa Pakamwa pakamwa palinso 0,125 / 0,2 / 0,4 g (5 ml) amoxicillin trihydrate ndipo, motero, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Zothandiza: Xanthan chingamu, Hydroxypropyl methylcellulose, Silicii dioxydum colloidale, Acidum presinicum, Silicii dioxydum, Aspartamum (E951), youma - malalanje a lalanje (610271E ndi 9/27108), rasipiberi ndi "Bright molasses".

Mu ufa Augmentin EU idakonzekera Kukonzekera kwa 100 ml kuyimitsidwaili ndi 0,6 g (5 ml) amoxicillin trihydrate ndi 0.0429 g (5 ml) clavulanic acid.

Zothandiza: Silicii dioxydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan chingamu, Silicii dioxydum, kukoma kwa sitiroberi 544428.

Mu kapangidwe kake Mapiritsi a Augmentin CP ndi nthawi yayitali gwiritsani ntchito 1 g amoxicillin trihydrate ndi 0.0625 g clavulanic acid.

Zothandiza: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxydum colloidale, Magnesium stearate, Xanthan gum, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogum 3350, Macrogolum 3350.

Mankhwalawa ali ndi mitundu yotulutsira iyi:

• Mapiritsi a Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg ndi Augmentin 875 + 125 mg.
• Powder 500/100 mg ndi 1000/200 mg, omwe cholinga chake ndi kukonza njira yothetsera jakisoni.
• Ufa wa kuyimitsidwa kwa Augmentin 400 mg / 57 mg, 200 mg / 28,5 mg, 125 mg / 31.25 mg.
• Powder Augmentin EU 600 mg / 42.9 mg (5 ml) kuyimitsidwa.
• Augmentin CP 1000 mg / 62,5 mg mapiritsi olimbitsa otulutsidwa

Augmentin ali m'gulu la pharmacotherapeutic gulu la mankhwala oletsa kugwiritsa ntchito mankhwalawa. Ma β lactams. Penicillin. ”

Mphamvu ya mankhwalawa antibacterial ndi bactericidal.

Pharmacodynamics ndi pharmacokinetics

Malinga ndi Wikipedia, Amoxicillin ndiye bactericidal wothandizirayogwira polimbana ndi tizilombo tating'onoting'ono tambiri komanso tating'onoting'ono tating'onoting'ono tizilombo ndikuyimira semisynthetic penicillin gulu la mankhwala.

Kupondereza transpeptidase ndikusokoneza njira zopangira mureina (gawo lofunikira kwambiri la makoma a cell ya bakiteriya) panthawi yamagawidwe ndi kukula, zimapangitsa kuti ziwonongeke (chiwonongeko) mabakiteriya.

Amoxicillin wawonongedwa β-lactamaseschifukwa chake ntchito ya antibacterial sikufikira tizilombokupanga β-lactamases.

Kuchita ngati mpikisano ndipo nthawi zambiri ndi cholepheretsa chosasintha, clavulanic acid yodziwika ndi kuthekera kolowera mkati mwa makoma am'nyumba mabakiteriya ndikupangitsa inactivation michereZomwe zili mkati mwa khungu ndi m'malire ake.

Clavulanate mitundu yosakhazikika inasinthidwa ndi β-lactamasesndipo izi zimalepheretsa chiwonongeko amoxicillin.

Mankhwala a Augmentin amagwira ntchito motsutsana:

• Gram (+) aerobes: pyogenic streptococcus magulu A ndi B, pneumococci, Staphylococcus aureus ndi epidermal, (kupatulapo michere yolimbana ndi methicillin), saprophytic staphylococcus ndi ena
• Gram (-) aerobes: Ndodo za Pfeiffer, wambiri chifuwa, gardnerella vaginalis , cholera vibrio etc.
• Gram (+) ndi Gram (-) ya anaerobes: ma bacteria, fusobacteria, preotellas etc.
• Tizilombo tina: chlamydia, spirochete, wotumbululuka treponema etc.

Pambuyo pomeza Augmentin, mbali zake zonse ziwiri zimagwira ntchito mwachangu komanso mwachangu. Mafuta akumwa bwino ngati mapiritsi kapena manyumwa aledzera pakudya (kumayambiriro kwa chakudya).

Onse akumwa pakamwa, komanso poyambitsa yankho la Augmentin IV, njira zochizira zomwe amagwiritsa ntchito zimapezeka mu minyewa yonse komanso madzi amkati.

Magawo onse awiriwa amagwira plasma magazi mapuloteni (mpaka 25% imamangiriza mapuloteni a plasma amoxicillin trihydrate ndipo osaposa 18% clavulanic acid) Palibe kukondoweza kwa Augmentin komwe kwapezeka m'ziwalo zilizonse zamkati.

Amoxicillin kuvumbulutsidwa kwa kagayidwe mthupi ndipo wachotsedwa impsokudzera m'mimba yogaya komanso momwe mpweya umatulutsira mpweya limodzi ndi mpweya. 10 mpaka 25% ya mlingo womwe walandiridwa amoxicillin kuchotseredwa impso mu mawonekedwe penicilloic acidzomwe sizigwira ntchito metabolite.

Clavulanate chafufutsidwa ndi impso komanso njira zina zowonjezera.

Zizindikiro zogwiritsidwa ntchito

Zizindikiro pakugwiritsa ntchito kuphatikiza amoxicillin trihydrate ndi clavulanic acid ndi matendawokwiyitsidwa ndi chidwi ndi zomwe zinthu izi zimapanga tizilombo.

Chithandizo cha Augmentin chololedwa. matendachifukwa cha ntchito tizilombowoganizira zochita amoxicillinkomanso kusakanikirana matendakupsa mtima ndi mabakiteriya amoxicillin ndi mabakiteriya omwe amatulutsa β-lactamase ndipo amadziwika ndi kuphatikizika kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Pa intaneti, mafunso amafunsidwa kuti: "Kodi mapiritsi a Augmentin ndi ati? "Kapena" Kodi Kugulitsa kwa Augmentin Syrup? ".

Kukula kwa mankhwalawa ndikwakukulu. Amalemba zotsatirazi matenda opatsirana komanso otupa:

• at matendakukhudza chapamwamba ndi chapansi chopumira (kuphatikiza kuphatikizapo Matenda a ENT),
• at matendakukhudza genitourinary thirakiti,
• at matenda a odontogenic (mkamwa),
• at matenda azamatenda,
• at chinzonono,
• at matendakukhudza khungu ndi minofu yofewa,
• at matendakukhudza minofu yamafupa (kuphatikiza ngati kuli kofunikira, kuikidwa kwa chithandizo chanthawi yayitali kwa wodwala),
• zinthu zina matenda mtundu wosakanikirana (i.e. pambuyo kuchotsa mimba kwa septicat sepsis nthawi yobereka, septicemia (sepsis yopanda metastases), peritonitisat sepsischifukwa intraabdominal matendaat matendakupanga pambuyo opaleshoni kuchitapo kanthu).

Augmentin nthawi zambiri amagwiritsidwa ntchito ngati njira yodzitetezera asanapangire opareshoni yayikulu mutu, khosi, matenda am'mimba, impso, mafupa am'mimba, ziwalo zomwe zili m'chiunokomanso munthawi ya njirayi kukhazikika kwa ziwalo zamkati.

Augmentin mu mitundu yonse ya mulingo wolembedwa:

• odwala hypersensitivity amodzi kapena onse yogwira mankhwala, kwa aliyense wa iwo β-lactam (i.e. to maantibayotiki ochokera m'magulu penicillin ndi cephalosporin),
• odwala omwe akumana ndi machitidwe a Augmentin chithandizo jaundice kapena mbiri yachitetezo cha ntchito chiwindi chifukwa chogwiritsa ntchito kuphatikiza pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Kutsutsana kwapadera pakukhazikitsidwa kwa ufa pokonzekera kuyimitsidwa pakamwa ndi Mlingo wa zinthu zofunikira za 125 + 31.25 mg ndi PKU (phenylketonuria).

Ufa womwe umagwiritsidwa ntchito pokonzekera kuyimitsidwa kwa pakamwa ndi Mlingo wa zinthu zofunikira (200 + 28,5) ndi (400 + 57) mg ndi zotsutsana:

• at PKU,
• odwala osokonezeka impsokomwe zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi
• ana osakwana miyezi itatu.

Zowonjezera zina zotsutsana ndikugwiritsa ntchito mapiritsi okhala ndi Mlingo wa zinthu zomwe zimagwira (250 + 125) ndi (500 + 125) mg ali ndi zaka 12 kapena / kapena zolemera zosakwana 40 kilogalamu.

Mapiritsi okhala ndi Mlingo wa yogwira zinthu 875 + 125 mg ndiwotsutsana:

• kuphwanya ntchito yogwira ntchito impso (Zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi)
• ana ochepera zaka 12
• odwala omwe kulemera kwawo kwa thupi sikupitirira 40 kg.

Zotsatira zoyipa za Augmentin zimatha kuchokera ku kachitidwe kosiyanasiyana ndi ziwalo zina. Nthawi zambiri, motsutsana ndi momwe mankhwalawo amathandizira pakumwa mankhwala osokoneza bongo, zotsatirazi zimadziwika:

• candidiasis (thrush) khungu ndi mucous nembanemba,
• kutsegula m'mimba (Nthawi zambiri - pomwa mapiritsi a Augmentin m'mapiritsi, nthawi zambiri mukamayimitsa kapena jekeseni),
• kusanza ndi kusanza (nseru) nthawi zambiri umapezeka pakumwa mankhwala okwanira.

Zotsatira zoyipa zomwe zimapezeka nthawi zambiri zimaphatikizapo:

• chizungulire,
• mutu,
• zopsinjika chimbudzi,
• kuchuluka zolimbitsa chiwindi ntchito enzyme alanine transaminases (ALT) ndi aspartate transaminases (AST),
• zotupa pakhungu, Khungumawonetseredwe urticaria.

Nthawi zina, thupi limatha kuyankha kuti Augmentin alandire:

• chosintha leukopenia (kuphatikiza kuphatikizapo agranulocytosis),
  thrombocytopenia,
• chitukuko thrombophlebitis pamalo opangira jekeseni
• polymorphic erythema.

Sipangakhale izi:

• hemolytic anemia,
• mikhalidwe yodziwika ndi kuwonjezereka kwa nthawi yayitali magazi ndi kuchuluka prothrombin index,
• zimachitika kuchokera chitetezo cha mthupizomwe zikufotokozedwa ngati angioedema, matenda ofanana ndi amene awonetsedwa matenda a seramu, anaphylaxis, Matupi a vasculitis,
• Hyperacaction mtundu wosinthika
• kuchuluka ntchito zopweteka,
• mitengochifukwa cholandila maantibayotikikuphatikiza kuphatikizapo pseudomembranous (PMK) ndi hemorrhagic (mwayi wokhala ndi vuto lomaliza umachepa ngati Augmentin amaperekedwa ndi makolo),
• keratinization ndi kukula kwa papillae wooneka ngati malilime wokhala lilime (matenda otchedwa “lilime lakuda”),
• chiwindi ndi intrahepatic cholestasis,
• Matenda a Lyell,
• chachikulu pustulosis mu mawonekedwe
• interstitial nephritis,
• kuwoneka mkodzo wamakristali amchere (khalid).

M'malo mwa chilichonse dermatitis Thupi lawo siligwirizana Augmentin ziyenera kusiyidwa.

Ntchito malangizo Augmentin: njira ntchito, Mlingo wa odwala ndi ana akuluakulu

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo mwachindunji. asanadye.

Choyamba, zimapereka kuyamwa bwino kwa zinthu zomwe zimagwira Matumbo, ndipo, chachiwiri, zimachepetsa kwambiri kuvuta dyspeptic matenda am'mimba thirakitingati izi zili choncho.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso muyezo wochizira, kutengera zomwe tizilombo Ndi tizilombo toyambitsa matenda, timakhudzidwa motani ndi kukhudzana mankhwala, zovuta ndi machitidwe a matendawa, kudziwa kwawonekera kwa matenda opatsirana, zaka komanso kulemera kwa wodwala, komanso momwe alili wathanzi impso wodwala.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg + 125 mg) - kamodzi katatu patsiku. Mlingo wotere, mankhwalawa akuwonetsedwa matendaomwe amayenda zosavuta kapena mawonekedwe owopsa. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi a 625 mg (500 mg + 125 mg) - kamodzi katatu patsiku.
• Mapiritsi a 1000 mg (875 mg + 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto la ntchito. impso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Odwala odwala impso The mankhwala zotchulidwa pokhapokha ngati chizindikiro Mayeso a Reberg amapitilira 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo safunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa iwo omwe ali ndi zovuta matenda - aliyense maola asanu ndi limodzi kapena anayi (malingana ndi mawonekedwe).

Antibiotic mwanjira yothetsera yankho, 500 mg / 100 mg kapena 1000 mg / 200 mg ndi mankhwala wotseka chitukuko matenda pambuyo opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kulowa wodwala kamodzi opaleshoni Mlingo wa Augmentin 1000 mg / 200 mg.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Masiku ano, mankhwalawa amapezeka mu mitundu yambiri ya mankhwala. zilonda zapakhosi.

Ana Augmentin ndi zilonda zapakhosi zotchulidwa muyezo kuti amadzipereka zochokera thupi ndi zaka za mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin pa 875 + 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsuko yamkati yamtunduwo Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku. Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Kuchulukitsa mlingo wa Augmentin limodzi ndi:

• chitukuko cha kuphwanya kugaya chakudya,
• kuphwanya mulingo wamchere wamadzi,
• khalid,
• kulephera kwa aimpso,
• mpweya (mpweya) wa amoxicillin mu catheter wa kwamikodzo.

Zizindikiro zotere zikawoneka, wodwalayo amawonetsedwa monga chithandizo cha mankhwala, kuphatikiza pazinthu zina, kukonza kwa mchere wamchere wamchere.Kuchotsedwa kwa Augmentin ku kutidongosolo lofanana imathandizanso njirayi hemodialysis.

Yofanana makonzedwe a mankhwala phenenecid:

• amathandizira kuchepetsa katulutsidwe katulutsidwe amo amoillillin,
• kumapangitsa kuchuluka kwa ndende amoxicillin mu magazi a m'magazi (zotsatira zake zikupitilira kwanthawi yayitali),
• sizikhudza malo ndi kuchuluka kwa zomwe zili plasma wa clavulanic acid.

Kuphatikiza amoxicillin ndi allopurinol kumawonjezera mwayi kukulitsa mawonekedwe chifuwa. Chiyanjano Pakati allopurinol nthawi yomweyo ndi magawo awiri azigawo a Augmentan palibe.

Augmentin ali ndi tanthauzo pa zomwe zili matumbo thirakiti microflorazomwe zimadzetsa kuchepa kwa kubwezeretsanso (kupatutsa kuyamwa) estrogen, komanso kuchepa kwa magwiridwe antchito ophatikizika njira zakulera pakamwa.

Mankhwalawa sagwirizana ndi zinthu zamagazi ndi zinthu zama protein, kuphatikizapo kuphatikiza Whey protein hydrolysates ndi emulsions yamafuta omwe cholinga chake ndi kulowetsedwa mu mtsempha.

Ngati Augmentin adayikidwa pamodzi maantibayotiki kalasi aminoglycosides, mankhwalawa sanaphatikizidwe mu syringe imodzi kapena chidebe chilichonse musanayende, chifukwa izi zimapangitsa kuti inactivation aminoglycosides.

Kukonzekera koyambirira komwe kumasungidwa kumatenthedwe osapitirira 25 ° C. Kuyimitsidwa kuyenera kusungidwa pa kutentha kwa 2-8 ° C (kwakukulu mufiriji) osaposa masiku 7.

Ndizoyenera kugwiritsidwa ntchito mkati mwa zaka 2 kuyambira tsiku lopangira.

Ma Analogs a AugmentinKufanana kwa code ya ATX Level 4:

Ma analog a Augmentin ndi mankhwala osokoneza bongo A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Samalirani, Teraclav.

Iliyonse mwamankhwala omwe ali pamwambapa ndi omwe Augmentin amatha kusinthidwa posakhalapo.

Mtengo wa analogues umasiyana kuchokera pa 63.65 mpaka 333.97 UAH.

Augmentin wa ana

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana mankhwala nthawi zambiri zotchulidwa zilonda zapakhosi. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg + 125 mg katatu patsiku,
• piritsi limodzi 500 + 125 mg kawiri patsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg + 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo. Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Ma analogu a Augmentin, omwe ali m'malo ake a pharmacological, ndi mankhwala osokoneza bongo Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Mochulukitsa.

Kuyenderana ndi mowa

Augmentin ndi mowa ndiye kuti sikuti amatsutsana ndi mowa wa ethyl mankhwala sasintha momwe amagulitsira mankhwala.

Ngati motsutsana ndi maziko a mankhwala osokoneza bongo mukufunika kumwa mowa, ndikofunikira kutsatira ziwiri izi: kusanja komanso kuthamanga.

Kwa anthu omwe akudwala mowa, kugwiritsa ntchito mankhwalawa pamodzi ndi mowa kumatha kukhala ndi zotsatirapo zowopsa.

Kuledzeretsa mwadongosolo kumadzetsa zisokonezo zosiyanasiyana pantchito chiwindi. Odwala odwala chiwindi Malangizowo akuwonetsa kuti Augmentin akhazikitsidwe mosamala kwambiri, chifukwa zimanenedweratu momwe chiwalo chodwala chizitha kuyeserera xenobioticzovuta kwambiri.

Chifukwa chake, popewa chiopsezo chosavomerezeka, tikulimbikitsidwa kuti musamwe mowa nthawi yonse ya mankhwalawa.

Augmentin pa nthawi yoyembekezera

Monga maantibayotiki ambiri gulu la penicillin, amoxicillin, yogawidwa m'thupi lathu, imalowanso mkaka wa m'mawere. Kuphatikiza apo, zofufuza zimatha kupezeka mkaka. clavulanic acid.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza clavulanic acid ndi amoxicillin zimatha kuyambitsa khanda kutsegula m'mimba ndi / kapena candidiasis (thrush) wa mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zothandiza za Augmentin zimatha kulowa hematoplacental (GPB) chotchinga. Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kungayambitse khanda lobadwa kumene necrotizing enterocolitis (NEC).

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Ndemanga za Augmentin

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin gawo lalikulu zabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin osiyidwa ndi amayi a ana aang'ono zikuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana monga bronchitis kapena zilonda zapakhosi. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake. Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo wa kuyimitsidwa kwa Augmentin kwa ana:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28,5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

• Mankhwala ogulitsa pa intaneti ku Russia
• Mankhwala ogulitsa pa intaneti ku UkraineUkraine
• Mankhwala ogulitsa pa intaneti ku Kazakhstan

Augmentin Powder 228.5 mg / 5 ml 7.7 g 70 ml GlaxoSmithKline

Augmentin mapiritsi 250 mg + 125 mg 20 ma PC. GlaxoSmithKline

Augmentin Powder 642.9 mg / 5 ml 100 ml

Augmentin Powder 457 mg / 5 ml 12,6 g 70 ml

Augmentin Powder 100 ml GlaxoSmithKline

Augmentin 250mg / 125mg No. 20 mapiritsi a SmithKline Beech PiElSi

Augmentin 125mg / 31.25mg / 5ml 100ml ufa kuyimitsidwa SmithKline Beech PiElSi

Augmentin EU ufa kuyimitsidwa 600mg + 42.9mg No. 1 botolo GlaxoSmithKline

Augmentin 1000mg No. 14 mapiritsi a SmithKline Beech PiElSi

Augmentin 200mg / 28.5mg / 5ml 70ml ufa kuyimitsidwa SmithKline Beech PiElSi

Mankhwala IFK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

Augmentin SB Pharmaceuticals (UK)

Tabu la Augmentin. 500mg / 125mg No. 14 Velcom Foundation GW (UK)

Mapiritsi a Augmentin BD 625mg No. 14 Velcom Foundation GW (UK)

Augmentin SRGlaxo Wellcome Production (France)

Augmentin ufa wokonzekera jakisoni wa 600mg No. 10Glaxso Velcom GW (Great Britain)

Pani Pharmacy

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin 500 mg / 125 mg No. 14 mapiritsi a SmithKline Beecham Pharmaceuticals (UK)

Augmentin 156 mg / 5 ml 100 ml por.d / many SmithKline Beecham Pharmaceuticals (UK)

Augmentin 400mg / 57mg / 5ml 35 ml por.d / susp. SmithKline Beecham Pharmaceuticals (UK)

Augmentin 875 mg / 125 mg No. 14 tabl.smithKline Beecham Pharmaceuticals (Great Britain)

Augmentin 200mg / 28.5mg / 5ml 70 ml por.d / kuyimitsidwa. SmithKline Beecham Pharmaceuticals (UK)

LAPANI ZOTSATIRA! Zambiri pamankhwala omwe ali pamalowo ndizokhudza zonse, zomwe zimatengedwa kuchokera kwa anthu ndipo sizingagwiritsidwe ntchito ngati lingaliro la kugwiritsa ntchito mankhwala munthawi ya chithandizo. Musanagwiritse ntchito mankhwala a Augmentin, onetsetsani kuti mwawonana ndi dokotala.

Kufotokozera kogwirizana ndi 26.09.2014

• Dzina lachi Latin: Augmentin
• Code ya ATX: J01CR02
• Chithandizo: Amoxicillin (Amoxicillin) + Clavulanic acid (Clavulanic acid)
• Wopanga: GlaxoSmithKline plc, UK

M'modzi piritsi yamlomo ili ndi 0,25, 0,5 kapena 0,875 g amoxicillin trihydrate ndi 0,125 g clavulanic acid(popanga mankhwalawa, sodium clavulanate imayikidwa ndi 5% yowonjezera).

Kuphatikizidwa ndi piritsi zothandizira: Silicii dioxydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Botolo limodzi ufa wokonzekera njira jakisoni ali ndi 0,5 kapena 1 g amoxicillin trihydrate ndipo, motero, 0,1 kapena 0,2 g clavulanic acid.

The zikuchokera Augmentin ufa woyimitsidwa Pakamwa pakamwa palinso 0,125 / 0,2 / 0,4 g (5 ml) amoxicillin trihydrate ndipo, motero, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Zothandiza: Xanthan chingamu, Hydroxypropyl methylcellulose, Silicii dioxydum colloidale, Acidum presinicum, Silicii dioxydum, Aspartamum (E951), youma - malalanje a lalanje (610271E ndi 9/27108), rasipiberi ndi "Bright molasses".

Mu ufa Augmentin EU idakonzekera Kukonzekera kwa 100 ml kuyimitsidwaili ndi 0,6 g (5 ml) amoxicillin trihydrate ndi 0.0429 g (5 ml) clavulanic acid.

Zothandiza: Silicii dioxydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan chingamu, Silicii dioxydum, kukoma kwa sitiroberi 544428.

Mu kapangidwe kake Mapiritsi a Augmentin CP ndi nthawi yayitali gwiritsani ntchito 1 g amoxicillin trihydrate ndi 0.0625 g clavulanic acid.

Zothandiza: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxydum colloidale, Magnesium stearate, Xanthan gum, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogum 3350, Macrogolum 3350.

Pharmacodynamics ndi pharmacokinetics

Malinga ndi Wikipedia, Amoxicillin ndiye bactericidal wothandizirayogwira polimbana ndi tizilombo tating'onoting'ono tambiri komanso tating'onoting'ono tating'onoting'ono tizilombo ndikuyimira semisynthetic penicillin gulu la mankhwala.

Kupondereza transpeptidase ndikusokoneza njira zopangira mureina (gawo lofunikira kwambiri la makoma a cell ya bakiteriya) panthawi yamagawidwe ndi kukula, zimapangitsa kuti ziwonongeke (chiwonongeko) mabakiteriya.

Amoxicillin wawonongedwa β-lactamaseschifukwa chake ntchito ya antibacterial sikufikira tizilombokupanga β-lactamases.

Kuchita ngati mpikisano ndipo nthawi zambiri ndi cholepheretsa chosasintha, clavulanic acid yodziwika ndi kuthekera kolowera mkati mwa makoma am'nyumba mabakiteriya ndikupangitsa inactivation michereZomwe zili mkati mwa khungu ndi m'malire ake.

Clavulanate mitundu yosakhazikika inasinthidwa ndi β-lactamasesndipo izi zimalepheretsa chiwonongeko amoxicillin.

Mankhwala a Augmentin amagwira ntchito motsutsana:

• Gram (+) aerobes: pyogenic streptococcus magulu A ndi B, pneumococci, Staphylococcus aureus ndi epidermal, (kupatulapo michere yolimbana ndi methicillin), saprophytic staphylococcus ndi ena
• Gram (-) aerobes: Ndodo za Pfeiffer, wambiri chifuwa, gardnerella vaginalis , cholera vibrio etc.
• Gram (+) ndi Gram (-) ya anaerobes: ma bacteria, fusobacteria, preotellasetc.
• Tizilombo tina: chlamydia, spirochete, wotumbululuka treponema etc.

Pambuyo pomeza Augmentin, mbali zake zonse ziwiri zimagwira ntchito mwachangu komanso mwachangu. Mafuta akumwa bwino ngati mapiritsi kapena manyumwa aledzera pakudya (kumayambiriro kwa chakudya).

Onse akumwa pakamwa, komanso poyambitsa yankho la Augmentin IV, njira zochizira zomwe amagwiritsa ntchito zimapezeka mu minyewa yonse komanso madzi amkati.

Magawo onse awiriwa amagwira plasma magazi mapuloteni (mpaka 25% imamangiriza mapuloteni a plasma amoxicillin trihydratendipo osaposa 18% clavulanic acid) Palibe kukondoweza kwa Augmentin komwe kwapezeka m'ziwalo zilizonse zamkati.

Amoxicillin kuvumbulutsidwa kwa kagayidwe mthupi ndipo wachotsedwa impsokudzera m'mimba yogaya komanso momwe mpweya umatulutsira mpweya limodzi ndi mpweya. 10 mpaka 25% ya mlingo womwe walandiridwa amoxicillin kuchotseredwa impso mu mawonekedwe penicilloic acidzomwe sizigwira ntchito metabolite.

Clavulanate chafufutsidwa ndi impso komanso njira zina zowonjezera.

Ntchito malangizo Augmentin: njira ntchito, Mlingo wa odwala ndi ana akuluakulu

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo mwachindunji. asanadye.

Choyamba, zimapereka kuyamwa bwino kwa zinthu zomwe zimagwira Matumbo, ndipo, chachiwiri, zimachepetsa kwambiri kuvuta dyspeptic matenda am'mimba thirakitingati izi zili choncho.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso muyezo wochizira, kutengera zomwe tizilombo Ndi tizilombo toyambitsa matenda, timakhudzidwa motani ndi kukhudzana mankhwala, zovuta ndi machitidwe a matendawa, kudziwa kwawonekera kwa matenda opatsirana, zaka komanso kulemera kwa wodwala, komanso momwe alili wathanzi impso wodwala.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg + 125 mg) - kamodzi katatu patsiku. Mlingo wotere, mankhwalawa akuwonetsedwa matendaomwe amayenda zosavuta kapena mawonekedwe owopsa. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi a 625 mg (500 mg + 125 mg) - kamodzi katatu patsiku.
• Mapiritsi a 1000 mg (875 mg + 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto la ntchito. impso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Odwala odwala impso The mankhwala zotchulidwa pokhapokha ngati chizindikiro Mayeso a Reberg amapitilira 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo safunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa iwo omwe ali ndi zovuta matenda - aliyense maola asanu ndi limodzi kapena anayi (malingana ndi mawonekedwe).

Antibiotic mwanjira yothetsera yankho, 500 mg / 100 mg kapena 1000 mg / 200 mg ndi mankhwala wotseka chitukuko matenda pambuyo opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kulowa wodwala kamodzi opaleshoni Mlingo wa Augmentin 1000 mg / 200 mg.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Masiku ano, mankhwalawa amapezeka mu mitundu yambiri ya mankhwala. zilonda zapakhosi.

Ana Augmentin ndi zilonda zapakhosi zotchulidwa muyezo kuti amadzipereka zochokera thupi ndi zaka za mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin pa 875 + 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsuko yamkati yamtunduwo Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku. Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Ma Analogs a Augmentin

Ma analog a Augmentin ndi mankhwala osokoneza bongo A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Samalirani, Teraclav.

Iliyonse mwamankhwala omwe ali pamwambapa ndi omwe Augmentin amatha kusinthidwa posakhalapo.

Mtengo wa analogues umasiyana kuchokera pa 63.65 mpaka 333.97 UAH.

Augmentin wa ana

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana mankhwalanthawi zambiri zotchulidwa zilonda zapakhosi. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg + 125 mg katatu patsiku,
• piritsi limodzi 500 + 125 mg kawiri patsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg + 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo. Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Ma analogu a Augmentin, omwe ali m'malo ake a pharmacological, ndi mankhwala osokoneza bongo Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Mochulukitsa.

Kuyenderana ndi mowa

Augmentin ndi mowa ndiye kuti sikuti amatsutsana ndi mowa wa ethyl mankhwalasasintha momwe amagulitsira mankhwala.

Ngati motsutsana ndi maziko a mankhwala osokoneza bongo mukufunika kumwa mowa, ndikofunikira kutsatira ziwiri izi: kusanja komanso kuthamanga.

Kwa anthu omwe akudwala mowa, kugwiritsa ntchito mankhwalawa pamodzi ndi mowa kumatha kukhala ndi zotsatirapo zowopsa.

Kuledzeretsa mwadongosolo kumadzetsa zisokonezo zosiyanasiyana pantchito chiwindi. Odwala odwala chiwindi Malangizowo akuwonetsa kuti Augmentin akhazikitsidwe mosamala kwambiri, chifukwa zimanenedweratu momwe chiwalo chodwala chizitha kuyeserera xenobioticzovuta kwambiri.

Chifukwa chake, popewa chiopsezo chosavomerezeka, tikulimbikitsidwa kuti musamwe mowa nthawi yonse ya mankhwalawa.

Augmentin pa nthawi yoyembekezera

Monga maantibayotiki ambiri gulu la penicillin, amoxicillin, yogawidwa m'thupi lathu, imalowanso mkaka wa m'mawere. Kuphatikiza apo, zofufuza zimatha kupezeka mkaka. clavulanic acid.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza clavulanic acid ndi amoxicillin zimatha kuyambitsa khanda kutsegula m'mimba ndi / kapena candidiasis (thrush) wa mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zothandiza za Augmentin zimatha kulowa hematoplacental (GPB) chotchinga. Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kungayambitse khanda lobadwa kumene necrotizing enterocolitis (NEC).

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Ndemanga za Augmentin

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin gawo lalikulu zabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin osiyidwa ndi amayi a ana aang'ono zikuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana monga bronchitis kapena zilonda zapakhosi. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Mtengo wa Augmentin

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake. Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo wa kuyimitsidwa kwa Augmentin kwa ana:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28,5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Kufotokozera za mtundu wa kipimo

Mphamvu: yoyera kapena pafupifupi yoyera, yokhala ndi fungo labwino. Ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi koyera kumapangidwa. Poimirira, yoyera kapena yoyera imayamba pang'onopang'ono.

Mapiritsi, 250 mg + 125 mg: yokutidwa ndi nembanemba wa filimu kuyambira yoyera mpaka pafupi yoyera, yopanda mawonekedwe, yolembedwa "AUGMENTIN" mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mapiritsi, 500 mg + 125 mg: yokutidwa ndi chithunzi cha filimu kuyambira yoyera mpaka pafupifupi yoyera, chowongolera, cholembedwa "AC" ndikuyika pachiwopsezo mbali imodzi.

Mapiritsi, 875 mg + 125 mg: wokutidwa ndi filimu yolimba kuyambira yoyera mpaka yoyera, yoloweka mawonekedwe, yokhala ndi zilembo "A" ndi "C" mbali zonse ndi mzere wolakwika mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Zowonetsa Augmentin ®

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

matenda apamwamba a kupuma thirakiti (kuphatikizapo matenda a ENT), mwachitsanzo. Streptococcus pneumoniae, Haemophilus fuluwenza 1, Moraxella catarrhalis 1 ndi Streptococcus pyogene, (kupatula mapiritsi a Augmentin 250 mg / 125 mg),

matenda am'munsi kupuma, monga kufalikira kwa chifuwa, chibayo, ndi bronchopneumonia, yomwe imayamba chifukwa Streptococcus pneumoniae, Haemophilus fuluwenza 1 ndi Moraxella catarrhalis 1,

matenda amkodzo thirakiti, monga cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, nthawi zambiri amayamba chifukwa cha mitundu ya banja Enterobacteriaceae 1 (makamaka Escherichia coli 1 ), Staphylococcus saprophyticus ndi mitundu Enterococcuskomanso chinzonono choyambitsidwa ndi Nisseria gonorrhoeae 1,

khungu ndi minofu yofewa matenda omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, Streptococcus pyogene ndi mitundu Mabakiteriya 1,

matenda a mafupa ndi mafupa, monga osteomyelitis, omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, ngati ndi kotheka, chithandizo cha nthawi yayitali ndicotheka.

matenda a odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, mano owoneka kwambiri ndi kufalikira kwa cellulitis (piritsi la Augmentin piritsi, mlingo wa 500 mg / 125 mg, 875 mg / 125 mg),

matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (piritsi la Augmentin piritsi limodzi ndi 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Oimira pawokha amtundu wa tizilombo tating'onoting'ono timatulutsa beta-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin (onani. Pharmacodynamics).

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin ®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Augmentin ® amasonyezedwanso zochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa beta-lactamase, tcheru limodzi ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muchepetse kusokonezeka kwa m'mimba ndikuwonjezera kuyamwa, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya. Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita stepwise mankhwala (woyamba kholo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Tiyenera kukumbukira kuti 2 tabu. Augmentin ®, 250 mg + 125 mg siofanana ndi piritsi limodzi. Augmentin ®, 500 mg + 125 mg.

Akuluakulu ndi ana azaka 12 kapena kupitirira kapena masekeli 40 kapena kupitilira. Ndikulimbikitsidwa kugwiritsa ntchito 11 ml ya kuyimitsidwa pamlingo wa 400 mg + 57 mg mu 5 ml, wofanana ndi tebulo limodzi. Augmentin ®, 875 mg + 125 mg.

1 tabu. 250 mg + 125 mg katatu patsiku matenda opatsirana modekha. Mu matenda opweteka kwambiri (kuphatikiza matenda amkati ndi obwereza kwamkodzo, matenda oyamba ndi kupuma kwaposachedwa), mankhwala ena a Augmentin ® amalimbikitsidwa.

1 tabu. 500 mg + 125 mg katatu patsiku.

1 tabu. 875 mg + 125 mg kawiri pa tsiku.

Ana a zaka zitatu mpaka zaka 12 okhala ndi thupi lochepera 40 makilogalamu. Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mg / kg / tsiku kapena ml ya kuyimitsidwa. Mlingo wa tsiku ndi tsiku umagawidwa pakudya 3 tsiku lililonse kwa maola 8 aliwonse (125 mg + 31.25 mg) kapena 2 pa maola 12 aliwonse (200 mg + 28,5 mg, 400 mg + 57 mg). Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Mlingo wa Augmentin ® mlingo wa mankhwalawa kutengera amoxicillin

Mlingo wocheperako wa Augmentin ® amalimbikitsidwa zochizira matenda amkhungu ndi minyewa yofewa, komanso matendawo.

Mlingo wambiri wa Augmentin ® amalimbikitsidwa kuti azichiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma komanso kwamkodzo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsidwa ntchito kwa mankhwalawa Augmentin ® muyezo wa 40 mg + 10 mg / kg mu 3% yogawika (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu. Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin ® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Makanda obadwa asanakwane. Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Magulu apadera a odwala

Odwala okalamba. Malangizo a mtundu wa mankhwalawa safunikira; Okalamba odwala mkhutu aimpso ntchito, Mlingo woyenera amamulembera odwala omwe ali ndi vuto laimpso.

Odwala omwe ali ndi vuto la chiwindi. Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti musinthe malangizowo mwa odwala.

Odwala ndi mkhutu aimpso ntchito. Kuwongolera kwa dongosolo la mankhwalawa kumadalira kuchuluka kwa mlingo wovomerezeka wa amoxicillin ndi kufunika kwa chiwonetsero cha ntchito.

Malangizo a Augmentin ®

Mapiritsi okhala ndi mafilimu, 250 mg + 125 mg: Mlingo kusintha malinga ndi pazipita mlingo wa amoxicillin.

2 tabu. 250 mg + 125 mg mu gawo limodzi maola 24 aliwonse

Pa nthawi ya dialysis, piritsi limodzi (1 piritsi) ndi piritsi limodzi. kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Mapiritsi okhala ndi mafilimu, 500 mg + 125 mg: Mlingo kusintha malinga ndi pazipita mlingo wa amoxicillin.

1 tabu. 500 mg + 125 mg mu gawo limodzi maola 24 aliwonse

Pa nthawi ya dialysis, piritsi limodzi (1 piritsi) ndi piritsi limodzi. kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Njira yokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba. Pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti mutsimikizire kuchepetsedwa kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pafupifupi, pafupifupi 92 ml ya madzi amafunika kukonzekera kuyimitsidwa kwa Mlingo wa 125 mg + 31.25 mg ndi 64 ml ya madzi pa mlingo wa 200 mg + 28,5 mg ndi 400 mg + 57 mg.

Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin ® akhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Kutulutsa Fomu

Mapiritsi amlomo - zidutswa 14 papaketi iliyonse

Zotsatira za pharmacological

Mankhwala ophatikizidwa ndi yotakata yosakanikirana ndi β-lactamase yokhala ndi amoxicillin ndi clavulanic acid.

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi β-lactamases, chifukwa chake zochitika za amoxicillin sizingofikira ku tizilombo tating'onoting'ono timene timatulutsa enzymeyi.

Clavulanic acid, β-lactamase inhibitor yokhudzana ndi penicillin, amatha kupanga ma act lactamase osiyanasiyana opezeka mu penicillin ndi cephalosporin zosagwira tizilombo.

Clavulanic acid imagwira mokwanira motsutsana ndi plasmid β-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal β-lactamases ya mtundu 1 yomwe sikuletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu Augmentin CP kukonzekera kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - β-lactamases, omwe amalola kukulitsa kuchuluka kwa antibacterial a amoxicillin.

Chizindikiro chogwiritsidwa ntchito

Bacteria matenda oyambitsidwa ndi tizilombo tating'ono ta mankhwala:

• matenda a kumtunda kwa kupuma thirakiti ndi ziwalo za ENT (mwachitsanzo, tenillitisitis, sinusitis, atitis media), zomwe nthawi zambiri zimayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, Streptococcus pyogene,
• matenda apumidwe am'mimba thirakiti: kukokoloka kwa chifuwa cham'mimba, chibayo ndi bronchopneumonia, yomwe nthawi zambiri imayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae ndi Moraxella catarrhalis (kupatula mapiritsi 250 mg / 125 mg),
• matenda a kwamkodzo thirakiti: cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli *), Staphylococcus saprophyticus ndi mitundu ya mtundu wa Enterococcus,
• chinzonono chifukwa cha Neisseria gonorrhoeae (kupatula mapiritsi a 250 mg / 125 mg),
• matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus, Streptococcus pyogene ndi mitundu ya mtundu wa Bactero> Mlingo ndi makonzedwe

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin akulimbikitsidwa kuti idzatenge kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Contraindication

• hypersensitivity to amoxicillin, clavulanic acid, zinthu zina za mankhwalawa, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,
• magawo am'mbuyomu a jaundice kapena chiwindi chovuta kugwiritsa ntchito pophatikiza amoxicillin wokhala ndi clavulanic acid m'mbiri
• ana ochepera zaka 12 ndi kulemera kwa thupi zosakwana 40 kg

Malo osungira

Mankhwalawa amayenera kusungidwa kuti ana asawatenthe pa kutentha osaposa 25 ° C.

M'modzi piritsi yamlomo ili ndi 0,25, 0,5 kapena 0,875 g amoxicillin trihydrate ndi 0,125 g clavulanic acid (popanga mankhwalawa, sodium clavulanate imayikidwa ndi 5% yowonjezera).

Kuphatikizidwa ndi piritsi zothandizira: Silicii dioxydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Botolo limodzi ufa wokonzekera njira jakisoni ali ndi 0,5 kapena 1 g amoxicillin trihydrate ndipo, motero, 0,1 kapena 0,2 g clavulanic acid.

The zikuchokera Augmentin ufa woyimitsidwa Pakamwa pakamwa palinso 0,125 / 0,2 / 0,4 g (5 ml) amoxicillin trihydrate ndipo, motero, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Zothandiza: Xanthan chingamu, Hydroxypropyl methylcellulose, Silicii dioxydum colloidale, Acidum presinicum, Silicii dioxydum, Aspartamum (E951), youma - malalanje a lalanje (610271E ndi 9/27108), rasipiberi ndi "Bright molasses".

Mu ufa Augmentin EU idakonzekera Kukonzekera kwa 100 ml kuyimitsidwaili ndi 0,6 g (5 ml) amoxicillin trihydrate ndi 0.0429 g (5 ml) clavulanic acid.

Zothandiza: Silicii dioxydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan chingamu, Silicii dioxydum, kukoma kwa sitiroberi 544428.

Mu kapangidwe kake Mapiritsi a Augmentin CP ndi nthawi yayitali gwiritsani ntchito 1 g amoxicillin trihydrate ndi 0.0625 g clavulanic acid.

Zothandiza: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxydum colloidale, Magnesium stearate, Xanthan gum, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogum 3350, Macrogolum 3350.

Mankhwalawa ali ndi mitundu yotulutsira iyi:

• Mapiritsi a Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg ndi Augmentin 875 + 125 mg.
• Powder 500/100 mg ndi 1000/200 mg, omwe cholinga chake ndi kukonza njira yothetsera jakisoni.
• Ufa wa kuyimitsidwa kwa Augmentin 400 mg / 57 mg, 200 mg / 28,5 mg, 125 mg / 31.25 mg.
• Powder Augmentin EU 600 mg / 42.9 mg (5 ml) kuyimitsidwa.
• Augmentin CP 1000 mg / 62,5 mg mapiritsi olimbitsa otulutsidwa

Augmentin ali m'gulu la pharmacotherapeutic gulu la mankhwala oletsa kugwiritsa ntchito mankhwalawa. Ma β lactams. Penicillin. ”

Mphamvu ya mankhwalawa antibacterial ndi bactericidal.

Pharmacodynamics ndi pharmacokinetics

Malinga ndi Wikipedia, Amoxicillin ndiye bactericidal wothandizirayogwira polimbana ndi tizilombo tating'onoting'ono tambiri komanso tating'onoting'ono tating'onoting'ono tizilombo ndikuyimira semisynthetic penicillin gulu la mankhwala.

Kupondereza transpeptidase ndikusokoneza njira zopangira mureina (gawo lofunikira kwambiri la makoma a cell ya bakiteriya) panthawi yamagawidwe ndi kukula, zimapangitsa kuti ziwonongeke (chiwonongeko) mabakiteriya.

Amoxicillin wawonongedwa β-lactamaseschifukwa chake ntchito ya antibacterial sikufikira tizilombokupanga β-lactamases.

Kuchita ngati mpikisano ndipo nthawi zambiri ndi cholepheretsa chosasintha, clavulanic acid yodziwika ndi kuthekera kolowera mkati mwa makoma am'nyumba mabakiteriya ndikupangitsa inactivation michereZomwe zili mkati mwa khungu ndi m'malire ake.

Clavulanate mitundu yosakhazikika inasinthidwa ndi β-lactamasesndipo izi zimalepheretsa chiwonongeko amoxicillin.

Mankhwala a Augmentin amagwira ntchito motsutsana:

• Gram (+) aerobes: pyogenic streptococcus magulu A ndi B, pneumococci, Staphylococcus aureus ndi epidermal, (kupatulapo michere yolimbana ndi methicillin), saprophytic staphylococcus ndi ena
• Gram (-) aerobes: Ndodo za Pfeiffer, wambiri chifuwa, gardnerella vaginalis , cholera vibrio etc.
• Gram (+) ndi Gram (-) ya anaerobes: ma bacteria, fusobacteria, preotellas etc.
• Tizilombo tina: chlamydia, spirochete, wotumbululuka treponema etc.

Pambuyo pomeza Augmentin, mbali zake zonse ziwiri zimagwira ntchito mwachangu komanso mwachangu. Mafuta akumwa bwino ngati mapiritsi kapena manyumwa aledzera pakudya (kumayambiriro kwa chakudya).

Onse akumwa pakamwa, komanso poyambitsa yankho la Augmentin IV, njira zochizira zomwe amagwiritsa ntchito zimapezeka mu minyewa yonse komanso madzi amkati.

Magawo onse awiriwa amagwira plasma magazi mapuloteni (mpaka 25% imamangiriza mapuloteni a plasma amoxicillin trihydrate ndipo osaposa 18% clavulanic acid) Palibe kukondoweza kwa Augmentin komwe kwapezeka m'ziwalo zilizonse zamkati.

Amoxicillin kuvumbulutsidwa kwa kagayidwe mthupi ndipo wachotsedwa impsokudzera m'mimba yogaya komanso momwe mpweya umatulutsira mpweya limodzi ndi mpweya. 10 mpaka 25% ya mlingo womwe walandiridwa amoxicillin kuchotseredwa impso mu mawonekedwe penicilloic acidzomwe sizigwira ntchito metabolite.

Clavulanate chafufutsidwa ndi impso komanso njira zina zowonjezera.

Zizindikiro zogwiritsidwa ntchito

Zizindikiro pakugwiritsa ntchito kuphatikiza amoxicillin trihydrate ndi clavulanic acid ndi matendawokwiyitsidwa ndi chidwi ndi zomwe zinthu izi zimapanga tizilombo.

Chithandizo cha Augmentin chololedwa. matendachifukwa cha ntchito tizilombowoganizira zochita amoxicillinkomanso kusakanikirana matendakupsa mtima ndi mabakiteriya amoxicillin ndi mabakiteriya omwe amatulutsa β-lactamase ndipo amadziwika ndi kuphatikizika kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Pa intaneti, mafunso amafunsidwa kuti: "Kodi mapiritsi a Augmentin ndi ati? "Kapena" Kodi Kugulitsa kwa Augmentin Syrup? ".

Kukula kwa mankhwalawa ndikwakukulu. Amalemba zotsatirazi matenda opatsirana komanso otupa:

• at matendakukhudza chapamwamba ndi chapansi chopumira (kuphatikiza kuphatikizapo Matenda a ENT),
• at matendakukhudza genitourinary thirakiti,
• at matenda a odontogenic (mkamwa),
• at matenda azamatenda,
• at chinzonono,
• at matendakukhudza khungu ndi minofu yofewa,
• at matendakukhudza minofu yamafupa (kuphatikiza ngati kuli kofunikira, kuikidwa kwa chithandizo chanthawi yayitali kwa wodwala),
• zinthu zina matenda mtundu wosakanikirana (i.e. pambuyo kuchotsa mimba kwa septicat sepsis nthawi yobereka, septicemia (sepsis yopanda metastases), peritonitisat sepsischifukwa intraabdominal matendaat matendakupanga pambuyo opaleshoni kuchitapo kanthu).

Augmentin nthawi zambiri amagwiritsidwa ntchito ngati njira yodzitetezera asanapangire opareshoni yayikulu mutu, khosi, matenda am'mimba, impso, mafupa am'mimba, ziwalo zomwe zili m'chiunokomanso munthawi ya njirayi kukhazikika kwa ziwalo zamkati.

Augmentin mu mitundu yonse ya mulingo wolembedwa:

• odwala hypersensitivity amodzi kapena onse yogwira mankhwala, kwa aliyense wa iwo β-lactam (i.e. to maantibayotiki ochokera m'magulu penicillin ndi cephalosporin),
• odwala omwe akumana ndi machitidwe a Augmentin chithandizo jaundice kapena mbiri yachitetezo cha ntchito chiwindi chifukwa chogwiritsa ntchito kuphatikiza pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Kutsutsana kwapadera pakukhazikitsidwa kwa ufa pokonzekera kuyimitsidwa pakamwa ndi Mlingo wa zinthu zofunikira za 125 + 31.25 mg ndi PKU (phenylketonuria).

Ufa womwe umagwiritsidwa ntchito pokonzekera kuyimitsidwa kwa pakamwa ndi Mlingo wa zinthu zofunikira (200 + 28,5) ndi (400 + 57) mg ndi zotsutsana:

• at PKU,
• odwala osokonezeka impsokomwe zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi
• ana osakwana miyezi itatu.

Zowonjezera zina zotsutsana ndikugwiritsa ntchito mapiritsi okhala ndi Mlingo wa zinthu zomwe zimagwira (250 + 125) ndi (500 + 125) mg ali ndi zaka 12 kapena / kapena zolemera zosakwana 40 kilogalamu.

Mapiritsi okhala ndi Mlingo wa yogwira zinthu 875 + 125 mg ndiwotsutsana:

• kuphwanya ntchito yogwira ntchito impso (Zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi)
• ana ochepera zaka 12
• odwala omwe kulemera kwawo kwa thupi sikupitirira 40 kg.

Zotsatira zoyipa za Augmentin zimatha kuchokera ku kachitidwe kosiyanasiyana ndi ziwalo zina.Nthawi zambiri, motsutsana ndi momwe mankhwalawo amathandizira pakumwa mankhwala osokoneza bongo, zotsatirazi zimadziwika:

• candidiasis (thrush) khungu ndi mucous nembanemba,
• kutsegula m'mimba (Nthawi zambiri - pomwa mapiritsi a Augmentin m'mapiritsi, nthawi zambiri mukamayimitsa kapena jekeseni),
• kusanza ndi kusanza (nseru) nthawi zambiri umapezeka pakumwa mankhwala okwanira.

Zotsatira zoyipa zomwe zimapezeka nthawi zambiri zimaphatikizapo:

• chizungulire,
• mutu,
• zopsinjika chimbudzi,
• kuchuluka zolimbitsa chiwindi ntchito enzyme alanine transaminases (ALT) ndi aspartate transaminases (AST),
• zotupa pakhungu, Khungumawonetseredwe urticaria.

Nthawi zina, thupi limatha kuyankha kuti Augmentin alandire:

• chosintha leukopenia (kuphatikiza kuphatikizapo agranulocytosis),
  thrombocytopenia,
• chitukuko thrombophlebitis pamalo opangira jekeseni
• polymorphic erythema.

Sipangakhale izi:

• hemolytic anemia,
• mikhalidwe yodziwika ndi kuwonjezereka kwa nthawi yayitali magazi ndi kuchuluka prothrombin index,
• zimachitika kuchokera chitetezo cha mthupizomwe zikufotokozedwa ngati angioedema, matenda ofanana ndi amene awonetsedwa matenda a seramu, anaphylaxis, Matupi a vasculitis,
• Hyperacaction mtundu wosinthika
• kuchuluka ntchito zopweteka,
• mitengochifukwa cholandila maantibayotikikuphatikiza kuphatikizapo pseudomembranous (PMK) ndi hemorrhagic (mwayi wokhala ndi vuto lomaliza umachepa ngati Augmentin amaperekedwa ndi makolo),
• keratinization ndi kukula kwa papillae wooneka ngati malilime wokhala lilime (matenda otchedwa “lilime lakuda”),
• chiwindi ndi intrahepatic cholestasis,
• Matenda a Lyell,
• chachikulu pustulosis mu mawonekedwe
• interstitial nephritis,
• kuwoneka mkodzo wamakristali amchere (khalid).

M'malo mwa chilichonse dermatitis Thupi lawo siligwirizana Augmentin ziyenera kusiyidwa.

Ntchito malangizo Augmentin: njira ntchito, Mlingo wa odwala ndi ana akuluakulu

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo mwachindunji. asanadye.

Choyamba, zimapereka kuyamwa bwino kwa zinthu zomwe zimagwira Matumbo, ndipo, chachiwiri, zimachepetsa kwambiri kuvuta dyspeptic matenda am'mimba thirakitingati izi zili choncho.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso muyezo wochizira, kutengera zomwe tizilombo Ndi tizilombo toyambitsa matenda, timakhudzidwa motani ndi kukhudzana mankhwala, zovuta ndi machitidwe a matendawa, kudziwa kwawonekera kwa matenda opatsirana, zaka komanso kulemera kwa wodwala, komanso momwe alili wathanzi impso wodwala.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg + 125 mg) - kamodzi katatu patsiku. Mlingo wotere, mankhwalawa akuwonetsedwa matendaomwe amayenda zosavuta kapena mawonekedwe owopsa. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi a 625 mg (500 mg + 125 mg) - kamodzi katatu patsiku.
• Mapiritsi a 1000 mg (875 mg + 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto la ntchito. impso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Odwala odwala impso The mankhwala zotchulidwa pokhapokha ngati chizindikiro Mayeso a Reberg amapitilira 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo safunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa iwo omwe ali ndi zovuta matenda - aliyense maola asanu ndi limodzi kapena anayi (malingana ndi mawonekedwe).

Antibiotic mwanjira yothetsera yankho, 500 mg / 100 mg kapena 1000 mg / 200 mg ndi mankhwala wotseka chitukuko matenda pambuyo opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kulowa wodwala kamodzi opaleshoni Mlingo wa Augmentin 1000 mg / 200 mg.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Masiku ano, mankhwalawa amapezeka mu mitundu yambiri ya mankhwala. zilonda zapakhosi.

Ana Augmentin ndi zilonda zapakhosi zotchulidwa muyezo kuti amadzipereka zochokera thupi ndi zaka za mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin pa 875 + 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsuko yamkati yamtunduwo Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku. Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Kuchulukitsa mlingo wa Augmentin limodzi ndi:

• chitukuko cha kuphwanya kugaya chakudya,
• kuphwanya mulingo wamchere wamadzi,
• khalid,
• kulephera kwa aimpso,
• mpweya (mpweya) wa amoxicillin mu catheter wa kwamikodzo.

Zizindikiro zotere zikawoneka, wodwalayo amawonetsedwa monga chithandizo cha mankhwala, kuphatikiza pazinthu zina, kukonza kwa mchere wamchere wamchere. Kuchotsedwa kwa Augmentin ku kutidongosolo lofanana imathandizanso njirayi hemodialysis.

Yofanana makonzedwe a mankhwala phenenecid:

• amathandizira kuchepetsa katulutsidwe katulutsidwe amo amoillillin,
• kumapangitsa kuchuluka kwa ndende amoxicillin mu magazi a m'magazi (zotsatira zake zikupitilira kwanthawi yayitali),
• sizikhudza malo ndi kuchuluka kwa zomwe zili plasma wa clavulanic acid.

Kuphatikiza amoxicillin ndi allopurinol kumawonjezera mwayi kukulitsa mawonekedwe chifuwa. Chiyanjano Pakati allopurinol nthawi yomweyo ndi magawo awiri azigawo a Augmentan palibe.

Augmentin ali ndi tanthauzo pa zomwe zili matumbo thirakiti microflorazomwe zimadzetsa kuchepa kwa kubwezeretsanso (kupatutsa kuyamwa) estrogen, komanso kuchepa kwa magwiridwe antchito ophatikizika njira zakulera pakamwa.

Mankhwalawa sagwirizana ndi zinthu zamagazi ndi zinthu zama protein, kuphatikizapo kuphatikiza Whey protein hydrolysates ndi emulsions yamafuta omwe cholinga chake ndi kulowetsedwa mu mtsempha.

Ngati Augmentin adayikidwa pamodzi maantibayotiki kalasi aminoglycosides, mankhwalawa sanaphatikizidwe mu syringe imodzi kapena chidebe chilichonse musanayende, chifukwa izi zimapangitsa kuti inactivation aminoglycosides.

Kukonzekera koyambirira komwe kumasungidwa kumatenthedwe osapitirira 25 ° C. Kuyimitsidwa kuyenera kusungidwa pa kutentha kwa 2-8 ° C (kwakukulu mufiriji) osaposa masiku 7.

Ndizoyenera kugwiritsidwa ntchito mkati mwa zaka 2 kuyambira tsiku lopangira.

Ma Analogs a AugmentinKufanana kwa code ya ATX Level 4:

Ma analog a Augmentin ndi mankhwala osokoneza bongo A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Samalirani, Teraclav.

Iliyonse mwamankhwala omwe ali pamwambapa ndi omwe Augmentin amatha kusinthidwa posakhalapo.

Mtengo wa analogues umasiyana kuchokera pa 63.65 mpaka 333.97 UAH.

Augmentin wa ana

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana mankhwala nthawi zambiri zotchulidwa zilonda zapakhosi. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg + 125 mg katatu patsiku,
• piritsi limodzi 500 + 125 mg kawiri patsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg + 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo. Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Ma analogu a Augmentin, omwe ali m'malo ake a pharmacological, ndi mankhwala osokoneza bongo Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Mochulukitsa.

Kuyenderana ndi mowa

Augmentin ndi mowa ndiye kuti sikuti amatsutsana ndi mowa wa ethyl mankhwala sasintha momwe amagulitsira mankhwala.

Ngati motsutsana ndi maziko a mankhwala osokoneza bongo mukufunika kumwa mowa, ndikofunikira kutsatira ziwiri izi: kusanja komanso kuthamanga.

Kwa anthu omwe akudwala mowa, kugwiritsa ntchito mankhwalawa pamodzi ndi mowa kumatha kukhala ndi zotsatirapo zowopsa.

Kuledzeretsa mwadongosolo kumadzetsa zisokonezo zosiyanasiyana pantchito chiwindi. Odwala odwala chiwindi Malangizowo akuwonetsa kuti Augmentin akhazikitsidwe mosamala kwambiri, chifukwa zimanenedweratu momwe chiwalo chodwala chizitha kuyeserera xenobioticzovuta kwambiri.

Chifukwa chake, popewa chiopsezo chosavomerezeka, tikulimbikitsidwa kuti musamwe mowa nthawi yonse ya mankhwalawa.

Augmentin pa nthawi yoyembekezera

Monga maantibayotiki ambiri gulu la penicillin, amoxicillin, yogawidwa m'thupi lathu, imalowanso mkaka wa m'mawere.Kuphatikiza apo, zofufuza zimatha kupezeka mkaka. clavulanic acid.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza clavulanic acid ndi amoxicillin zimatha kuyambitsa khanda kutsegula m'mimba ndi / kapena candidiasis (thrush) wa mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zothandiza za Augmentin zimatha kulowa hematoplacental (GPB) chotchinga. Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kungayambitse khanda lobadwa kumene necrotizing enterocolitis (NEC).

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Ndemanga za Augmentin

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin gawo lalikulu zabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin osiyidwa ndi amayi a ana aang'ono zikuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana monga bronchitis kapena zilonda zapakhosi. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake. Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo wa kuyimitsidwa kwa Augmentin kwa ana:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28,5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

• Mankhwala ogulitsa pa intaneti ku Russia
• Mankhwala ogulitsa pa intaneti ku UkraineUkraine
• Mankhwala ogulitsa pa intaneti ku Kazakhstan

Augmentin Powder 228.5 mg / 5 ml 7.7 g 70 ml GlaxoSmithKline

Augmentin mapiritsi 250 mg + 125 mg 20 ma PC. GlaxoSmithKline

Augmentin Powder 642.9 mg / 5 ml 100 ml

Augmentin Powder 457 mg / 5 ml 12,6 g 70 ml

Augmentin Powder 100 ml GlaxoSmithKline

Augmentin 250mg / 125mg No. 20 mapiritsi a SmithKline Beech PiElSi

Augmentin 125mg / 31.25mg / 5ml 100ml ufa kuyimitsidwa SmithKline Beech PiElSi

Augmentin EU ufa kuyimitsidwa 600mg + 42.9mg No. 1 botolo GlaxoSmithKline

Augmentin 1000mg No. 14 mapiritsi a SmithKline Beech PiElSi

Augmentin 200mg / 28.5mg / 5ml 70ml ufa kuyimitsidwa SmithKline Beech PiElSi

Mankhwala IFK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

AugmentinSmithKline Beecham, UK

Augmentin SB Pharmaceuticals (UK)

Tabu la Augmentin. 500mg / 125mg No. 14 Velcom Foundation GW (UK)

Mapiritsi a Augmentin BD 625mg No. 14 Velcom Foundation GW (UK)

Augmentin SRGlaxo Wellcome Production (France)

Augmentin ufa wokonzekera jakisoni wa 600mg No. 10Glaxso Velcom GW (Great Britain)

Pani Pharmacy

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin pamenepo. d / p madzi 228.5mg / 5ml 70ml Glaxo Chabwino

Augmentin 500 mg / 125 mg No. 14 mapiritsi a SmithKline Beecham Pharmaceuticals (UK)

Augmentin 156 mg / 5 ml 100 ml por.d / many SmithKline Beecham Pharmaceuticals (UK)

Augmentin 400mg / 57mg / 5ml 35 ml por.d / susp. SmithKline Beecham Pharmaceuticals (UK)

Augmentin 875 mg / 125 mg No. 14 tabl.smithKline Beecham Pharmaceuticals (Great Britain)

Augmentin 200mg / 28.5mg / 5ml 70 ml por.d / kuyimitsidwa. SmithKline Beecham Pharmaceuticals (UK)

LAPANI ZOTSATIRA! Zambiri pamankhwala omwe ali pamalowo ndizokhudza zonse, zomwe zimatengedwa kuchokera kwa anthu ndipo sizingagwiritsidwe ntchito ngati lingaliro la kugwiritsa ntchito mankhwala munthawi ya chithandizo. Musanagwiritse ntchito mankhwala a Augmentin, onetsetsani kuti mwawonana ndi dokotala.

Kufotokozera kogwirizana ndi 26.09.2014

• Dzina lachi Latin: Augmentin
• Code ya ATX: J01CR02
• Chithandizo: Amoxicillin (Amoxicillin) + Clavulanic acid (Clavulanic acid)
• Wopanga: GlaxoSmithKline plc, UK

M'modzi piritsi yamlomo ili ndi 0,25, 0,5 kapena 0,875 g amoxicillin trihydrate ndi 0,125 g clavulanic acid(popanga mankhwalawa, sodium clavulanate imayikidwa ndi 5% yowonjezera).

Kuphatikizidwa ndi piritsi zothandizira: Silicii dioxydum colloidale, Magnesium stearate, Carboxymethylamylum natricum, Cellulosum microcrystallicum.

Botolo limodzi ufa wokonzekera njira jakisoni ali ndi 0,5 kapena 1 g amoxicillin trihydrate ndipo, motero, 0,1 kapena 0,2 g clavulanic acid.

The zikuchokera Augmentin ufa woyimitsidwa Pakamwa pakamwa palinso 0,125 / 0,2 / 0,4 g (5 ml) amoxicillin trihydrate ndipo, motero, 0.03125 / 0.0285 / 0.057 g (5 ml) clavulanic acid.

Zothandiza: Xanthan chingamu, Hydroxypropyl methylcellulose, Silicii dioxydum colloidale, Acidum presinicum, Silicii dioxydum, Aspartamum (E951), youma - malalanje a lalanje (610271E ndi 9/27108), rasipiberi ndi "Bright molasses".

Mu ufa Augmentin EU idakonzekera Kukonzekera kwa 100 ml kuyimitsidwaili ndi 0,6 g (5 ml) amoxicillin trihydrate ndi 0.0429 g (5 ml) clavulanic acid.

Zothandiza: Silicii dioxydum colloidale, Carboxymethylamylum natricum), Aspartamum (E951), Xanthan chingamu, Silicii dioxydum, kukoma kwa sitiroberi 544428.

Mu kapangidwe kake Mapiritsi a Augmentin CP ndi nthawi yayitali gwiritsani ntchito 1 g amoxicillin trihydrate ndi 0.0625 g clavulanic acid.

Zothandiza: Cellulosum microcrystallicum, Carboxymethylamylum natricum, Silicii dioxydum colloidale, Magnesium stearate, Xanthan gum, Acidum citrinosum, Hypromellosum 6cps, Hypromellosum 15cps, Titanium dioxide (E171), Macrogolum 3350, Macrogolum 3350, Macrogum 3350, Macrogolum 3350.

Kutulutsa Fomu

Mankhwalawa ali ndi mitundu yotulutsira iyi:

• Mapiritsi a Augmentin 250 mg + 125 mg, Augmentin 500 mg + 125 mg ndi Augmentin 875 + 125 mg.
• Powder 500/100 mg ndi 1000/200 mg, omwe cholinga chake ndi kukonza njira yothetsera jakisoni.
• Ufa wa kuyimitsidwa kwa Augmentin 400 mg / 57 mg, 200 mg / 28,5 mg, 125 mg / 31.25 mg.
• Powder Augmentin EU 600 mg / 42.9 mg (5 ml) kuyimitsidwa.
• Augmentin CP 1000 mg / 62,5 mg mapiritsi olimbitsa otulutsidwa

Zotsatira za pharmacological

Augmentin ali m'gulu la pharmacotherapeutic gulu la mankhwala oletsa kugwiritsa ntchito mankhwalawa. Ma β lactams. Penicillin. ”

Mphamvu ya mankhwalawa antibacterial ndi bactericidal.

Pharmacodynamics ndi pharmacokinetics

Malinga ndi Wikipedia, Amoxicillin ndiye bactericidal wothandizirayogwira polimbana ndi tizilombo tating'onoting'ono tambiri komanso tating'onoting'ono tating'onoting'ono tizilombo ndikuyimira semisynthetic penicillin gulu la mankhwala.

Kupondereza transpeptidase ndikusokoneza njira zopangira mureina (gawo lofunikira kwambiri la makoma a cell ya bakiteriya) panthawi yamagawidwe ndi kukula, zimapangitsa kuti ziwonongeke (chiwonongeko) mabakiteriya.

Amoxicillin wawonongedwa β-lactamaseschifukwa chake ntchito ya antibacterial sikufikira tizilombokupanga β-lactamases.

Kuchita ngati mpikisano ndipo nthawi zambiri ndi cholepheretsa chosasintha, clavulanic acid yodziwika ndi kuthekera kolowera mkati mwa makoma am'nyumba mabakiteriya ndikupangitsa inactivation michereZomwe zili mkati mwa khungu ndi m'malire ake.

Clavulanate mitundu yosakhazikika inasinthidwa ndi β-lactamasesndipo izi zimalepheretsa chiwonongeko amoxicillin.

Mankhwala a Augmentin amagwira ntchito motsutsana:

• Gram (+) aerobes: pyogenic streptococcus magulu A ndi B, pneumococci, Staphylococcus aureus ndi epidermal, (kupatulapo michere yolimbana ndi methicillin), saprophytic staphylococcus ndi ena
• Gram (-) aerobes: Ndodo za Pfeiffer, wambiri chifuwa, gardnerella vaginalis , cholera vibrio etc.
• Gram (+) ndi Gram (-) ya anaerobes: ma bacteria, fusobacteria, preotellasetc.
• Tizilombo tina: chlamydia, spirochete, wotumbululuka treponema etc.

Pambuyo pomeza Augmentin, mbali zake zonse ziwiri zimagwira ntchito mwachangu komanso mwachangu. Mafuta akumwa bwino ngati mapiritsi kapena manyumwa aledzera pakudya (kumayambiriro kwa chakudya).

Onse akumwa pakamwa, komanso poyambitsa yankho la Augmentin IV, njira zochizira zomwe amagwiritsa ntchito zimapezeka mu minyewa yonse komanso madzi amkati.

Magawo onse awiriwa amagwira plasma magazi mapuloteni (mpaka 25% imamangiriza mapuloteni a plasma amoxicillin trihydratendipo osaposa 18% clavulanic acid) Palibe kukondoweza kwa Augmentin komwe kwapezeka m'ziwalo zilizonse zamkati.

Amoxicillin kuvumbulutsidwa kwa kagayidwe mthupi ndipo wachotsedwa impsokudzera m'mimba yogaya komanso momwe mpweya umatulutsira mpweya limodzi ndi mpweya. 10 mpaka 25% ya mlingo womwe walandiridwa amoxicillin kuchotseredwa impso mu mawonekedwe penicilloic acidzomwe sizigwira ntchito metabolite.

Clavulanate chafufutsidwa ndi impso komanso njira zina zowonjezera.

Zizindikiro zogwiritsidwa ntchito

Zizindikiro pakugwiritsa ntchito kuphatikiza amoxicillin trihydrate ndi clavulanic acid ndi matendawokwiyitsidwa ndi chidwi ndi zomwe zinthu izi zimapanga tizilombo.

Chithandizo cha Augmentin chololedwa. matendachifukwa cha ntchito tizilombowoganizira zochita amoxicillinkomanso kusakanikirana matendakupsa mtima ndi mabakiteriya amoxicillin ndi mabakiteriya omwe amatulutsa β-lactamasendipo amadziwika ndi kuphatikizika kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Pa intaneti, mafunso amafunsidwa kuti: "Kodi mapiritsi a Augmentin ndi ati? "Kapena" Kodi Kugulitsa kwa Augmentin Syrup? ".

Kukula kwa mankhwalawa ndikwakukulu. Amalemba zotsatirazi matenda opatsirana komanso otupa:

• at matendakukhudza chapamwamba ndi chapansi chopumira (kuphatikiza kuphatikizapo Matenda a ENT),
• at matendakukhudza genitourinary thirakiti,
• at matenda a odontogenic (mkamwa),
• at matenda azamatenda,
• at chinzonono,
• at matendakukhudza khungu ndi minofu yofewa,
• at matendakukhudza minofu yamafupa(kuphatikiza ngati kuli kofunikira, kuikidwa kwa chithandizo chanthawi yayitali kwa wodwala),
• zinthu zina matenda mtundu wosakanikirana (i.e. pambuyo kuchotsa mimba kwa septicat sepsis nthawi yobereka, septicemia (sepsis yopanda metastases), peritonitisat sepsischifukwa intraabdominal matendaat matendakupanga pambuyo opaleshoni kuchitapo kanthu).

Augmentin nthawi zambiri amagwiritsidwa ntchito ngati njira yodzitetezera asanapangire opareshoni yayikulu mutu, khosi, matenda am'mimba, impso, mafupa am'mimba, ziwalo zomwe zili m'chiunokomanso munthawi ya njirayi kukhazikika kwa ziwalo zamkati.

Contraindication

Augmentin mu mitundu yonse ya mulingo wolembedwa:

• odwala hypersensitivity amodzi kapena onse yogwira mankhwala, kwa aliyense wa iwo β-lactam (i.e. to maantibayotiki ochokera m'magulu penicillin ndi cephalosporin),
• odwala omwe akumana ndi machitidwe a Augmentin chithandizo jaundice kapena mbiri yachitetezo cha ntchito chiwindi chifukwa chogwiritsa ntchito kuphatikiza pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwala.

Kutsutsana kwapadera pakukhazikitsidwa kwa ufa pokonzekera kuyimitsidwa pakamwa ndi Mlingo wa zinthu zofunikira za 125 + 31.25 mg ndi PKU (phenylketonuria).

Ufa womwe umagwiritsidwa ntchito pokonzekera kuyimitsidwa kwa pakamwa ndi Mlingo wa zinthu zofunikira (200 + 28,5) ndi (400 + 57) mg ndi zotsutsana:

• at PKU,
• odwala osokonezeka impsokomwe zizindikiroMayeso a Reberg pansipa 30 ml pa mphindi
• ana osakwana miyezi itatu.

Zowonjezera zina zotsutsana ndikugwiritsa ntchito mapiritsi okhala ndi Mlingo wa zinthu zomwe zimagwira (250 + 125) ndi (500 + 125) mg ali ndi zaka 12 kapena / kapena zolemera zosakwana 40 kilogalamu.

Mapiritsi okhala ndi Mlingo wa yogwira zinthu 875 + 125 mg ndiwotsutsana:

• kuphwanya ntchito yogwira ntchito impso (Zizindikiro Mayeso a Reberg pansipa 30 ml pa mphindi)
• ana ochepera zaka 12
• odwala omwe kulemera kwawo kwa thupi sikupitirira 40 kg.

Zotsatira zoyipa

Zotsatira zoyipa za Augmentin zimatha kuchokera ku kachitidwe kosiyanasiyana ndi ziwalo zina. Nthawi zambiri, motsutsana ndi momwe mankhwalawo amathandizira pakumwa mankhwala osokoneza bongo, zotsatirazi zimadziwika:

• candidiasis (thrush)khungu ndi mucous nembanemba,
• kutsegula m'mimba(Nthawi zambiri - pomwa mapiritsi a Augmentin m'mapiritsi, nthawi zambiri mukamayimitsa kapena jekeseni),
• kusanza ndi kusanza (nseru) nthawi zambiri umapezeka pakumwa mankhwala okwanira.

Zotsatira zoyipa zomwe zimapezeka nthawi zambiri zimaphatikizapo:

• chizungulire,
• mutu,
• zopsinjika chimbudzi,
• kuchuluka zolimbitsa chiwindi ntchito enzyme alanine transaminases (ALT)ndi aspartate transaminases (AST),
• zotupa pakhungu, Khungumawonetseredwe urticaria.

Nthawi zina, thupi limatha kuyankha kuti Augmentin alandire:

• chosintha leukopenia (kuphatikiza kuphatikizapo agranulocytosis),
  thrombocytopenia,
• chitukuko thrombophlebitis pamalo opangira jekeseni
• polymorphic erythema.

Sipangakhale izi:

• hemolytic anemia,
• mikhalidwe yodziwika ndi kuwonjezereka kwa nthawi yayitali magazi ndi kuchuluka prothrombin index,
• zimachitika kuchokera chitetezo cha mthupizomwe zikufotokozedwa ngati angioedema, matenda ofanana ndi amene awonetsedwa matenda a seramu, anaphylaxis, Matupi a vasculitis,
• Hyperacaction mtundu wosinthika
• kuchuluka ntchito zopweteka,
• mitengochifukwa cholandila maantibayotikikuphatikiza kuphatikizapo pseudomembranous (PMK) ndi hemorrhagic (mwayi wokhala ndi vuto lomaliza umachepa ngati Augmentin amaperekedwa ndi makolo),
• keratinization ndi kukula kwa papillae wooneka ngati malilime wokhala lilime (matenda otchedwa “lilime lakuda”),
• chiwindi ndi intrahepatic cholestasis,
• Matenda a Lyell,
• chachikulu pustulosismu mawonekedwe
• interstitial nephritis,
• kuwoneka mkodzo wamakristali amchere (khalid).

M'malo mwa chilichonse dermatitis Thupi lawo siligwirizana Augmentin ziyenera kusiyidwa.

Ntchito malangizo Augmentin: njira ntchito, Mlingo wa odwala ndi ana akuluakulu

Chimodzi mwazomwe zimafunsidwa kwambiri ndi wodwala ndikufunsa momwe mungamwe mankhwalawa musanadye kapena mutatha kudya. Pankhani ya Augmentin, kumwa mankhwalawa kumagwirizana kwambiri ndi kudya. Amamuwona ngati woyenera kumwa mankhwalawo mwachindunji. asanadye.

Choyamba, zimapereka kuyamwa bwino kwa zinthu zomwe zimagwira Matumbo, ndipo, chachiwiri, zimachepetsa kwambiri kuvuta dyspeptic matenda am'mimba thirakitingati izi zili choncho.

Momwe mungawerengere mlingo wa Augmentin

Momwe mungamwe mankhwalawa Augmentin kwa akulu ndi ana, komanso muyezo wochizira, kutengera zomwe tizilombo Ndi tizilombo toyambitsa matenda, timakhudzidwa motani ndi kukhudzana mankhwala, zovuta ndi machitidwe a matendawa, kudziwa kwawonekera kwa matenda opatsirana, zaka komanso kulemera kwa wodwala, komanso momwe alili wathanzi impso wodwala.

Kutalika kwa maphunzirowa kumatengera momwe thupi la wodwalayo limayankhira chithandizo.

Mapiritsi a Augmentin: malangizo ogwiritsira ntchito

Kutengera ndi zomwe zili ndi zomwe zili mmenemo, mapiritsi a Augmentin akulimbikitsidwa kuti odwala akuluakulu atenge malinga ndi dongosolo lotsatira:

• Augmentin 375 mg (250 mg + 125 mg) - kamodzi katatu patsiku. Mlingo wotere, mankhwalawa akuwonetsedwa matendaomwe amayenda zosavuta kapena mawonekedwe owopsa. Muzochitika za matenda akulu, kuphatikiza masiku ndi apo, Mlingo wapamwamba ndi mankhwala.
• Mapiritsi a 625 mg (500 mg + 125 mg) - kamodzi katatu patsiku.
• Mapiritsi a 1000 mg (875 mg + 125 mg) - kamodzi kawiri pa tsiku.

Mlingo umayenera kuwongoleredwa kwa odwala omwe ali ndi vuto la ntchito. impso.

Augmentin SR 1000 mg / 62,5 mg mapiritsi otulutsidwa otulutsidwa amangololeza kwa odwala azaka zopitilira 16. Mulingo woyenera ndi mapiritsi awiri kawiri patsiku.

Ngati wodwala sangameze piritsi lonse, lagawika pawiri molakwika. Ma halves onse awiri amatengedwa nthawi yomweyo.

Odwala odwala impso The mankhwala zotchulidwa pokhapokha ngati chizindikiro Mayeso a Reberg amapitilira 30 ml pa mphindi (ndiye kuti, ngati zosintha muyezo safunika).

Ufa wa yankho la jakisoni: malangizo ogwiritsira ntchito

Malinga ndi malangizo, yankho la jekeseni limalowa m'mitsempha: ndi jet (mlingo wonse uyenera kuperekedwa pakadutsa mphindi 3-4) kapena ndi njira ya kukapanda kuleka (kuchokera pakadutsa ola limodzi mpaka mphindi 40). Njira yothetsera vutoli sikuti idalowetsedwa m'matumbo.

Mlingo wokhazikika kwa wodwala wamkulu ndi 1000 mg / 200 mg. Ndikulimbikitsidwa kuti muzilowa maola asanu ndi atatu aliwonse, komanso kwa iwo omwe ali ndi zovuta matenda - aliyense maola asanu ndi limodzi kapena anayi (malingana ndi mawonekedwe).

Antibiotic mwanjira yothetsera yankho, 500 mg / 100 mg kapena 1000 mg / 200 mg ndi mankhwala wotseka chitukuko matenda pambuyo opaleshoni. Nthawi yomwe opaleshoniyo imakhala yochepera ola limodzi, ndikokwanira kulowa wodwala kamodzi opaleshoni Mlingo wa Augmentin 1000 mg / 200 mg.

Ngati mukuganiza kuti opaleshoniyo imatha kupitirira ola limodzi, mpaka madontho anayi a 1000 mg / 200 mg amaperekedwa kwa wodwala tsiku latha la maola 24.

Kuyimitsidwa kwa Augmentin: malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito Augmentin kwa ana amalimbikitsa kuperekedwa kwa kuyimitsidwa kwa 125 mg / 31.25 mg muyezo wa 2,5 mpaka 20 ml. Kuchulukana kwa phwando - 3 masana. Kuchuluka kwa mlingo umodzi kumatengera zaka ndi kulemera kwa mwana.

Ngati mwana ndi wamkulu kuposa miyezi iwiri, kuyimitsidwa kwa 200 mg / 28,5 mg amamulembera muyezo wofanana ndi 25 / 3,6 mg mpaka 45 / 6.4 mg pa 1 kg ya thupi. Mlingo womwe wafotokozedwayo uyenera kugawidwa pawiri.

Kuyimitsidwa ndi Mlingo wa yogwira zinthu 400 mg / 57 mg (Augmentin 2) akuwonetsedwa kuti azigwiritsidwa ntchito kuyambira chaka. Kutengera zaka komanso kulemera kwa mwana, mlingo umodzi umasiyana kuchokera pa 5 mpaka 10 ml. Kuchulukana kwa phwando - 2 masana.

Augmentin EU amalembedwa kuyambira miyezi itatu. Mulingo woyenera ndi 90 / 6.4 mg pa 1 kg ya kulemera kwa thupi patsiku (mlingo uyenera kugawidwa mu 2 Mlingo, kusunga maola 12 pakati pawo).

Masiku ano, mankhwalawa amapezeka mu mitundu yambiri ya mankhwala. zilonda zapakhosi.

Ana Augmentin ndi zilonda zapakhosi zotchulidwa muyezo kuti amadzipereka zochokera thupi ndi zaka za mwana. Ndi angina akuluakulu, tikulimbikitsidwa kugwiritsa ntchito Augmentin pa 875 + 125 mg katatu patsiku.

Komanso, nthawi zambiri amatengera kuikidwa kwa Augmentin sinusitis. Mankhwalawa amathandizidwa ndikutsuka mphuno ndi mchere wamchere ndikugwiritsira ntchito mitsuko yamkati yamtunduwo Rinofluimucil. Mlingo woyenera wa sinusitis: 875/125 mg 2 kawiri pa tsiku.Kutalika kwa maphunzirowa nthawi zambiri kumakhala masiku 7.

Bongo

Kuchulukitsa mlingo wa Augmentin limodzi ndi:

• chitukuko cha kuphwanya kugaya chakudya,
• kuphwanya mulingo wamchere wamadzi,
• khalid,
• kulephera kwa aimpso,
• mpweya (mpweya) wa amoxicillin mu catheter wa kwamikodzo.

Zizindikiro zotere zikawoneka, wodwalayo amawonetsedwa monga chithandizo cha mankhwala, kuphatikiza pazinthu zina, kukonza kwa mchere wamchere wamchere. Kuchotsedwa kwa Augmentin ku kutidongosolo lofanana imathandizanso njirayi hemodialysis.

Kuchita

• amathandizira kuchepetsa katulutsidwe katulutsidwe amo amoillillin,
• kumapangitsa kuchuluka kwa ndende amoxicillin mu magazi a m'magazi (zotsatira zake zikupitilira kwanthawi yayitali),
• sizikhudza malo ndi kuchuluka kwa zomwe zili plasma wa clavulanic acid.

Kuphatikiza amoxicillin ndi allopurinol kumawonjezera mwayi kukulitsa mawonekedwe chifuwa. Chiyanjano Pakati allopurinol nthawi yomweyo ndi magawo awiri azigawo a Augmentan palibe.

Augmentin ali ndi tanthauzo pa zomwe zili matumbo thirakiti microflorazomwe zimadzetsa kuchepa kwa kubwezeretsanso (kupatutsa kuyamwa) estrogen, komanso kuchepa kwa magwiridwe antchito ophatikizika njira zakulera pakamwa.

Mankhwalawa sagwirizana ndi zinthu zamagazi ndi zinthu zama protein, kuphatikizapo kuphatikiza Whey protein hydrolysates ndi emulsions yamafuta omwe cholinga chake ndi kulowetsedwa mu mtsempha.

Ngati Augmentin adayikidwa pamodzi maantibayotiki kalasi aminoglycosides, mankhwalawa sanaphatikizidwe mu syringe imodzi kapena chidebe chilichonse musanayende, chifukwa izi zimapangitsa kuti inactivation aminoglycosides.

Malonda ogulitsa

Malo osungira

Kukonzekera koyambirira komwe kumasungidwa kumatenthedwe osapitirira 25 ° C. Kuyimitsidwa kuyenera kusungidwa pa kutentha kwa 2-8 ° C (kwakukulu mufiriji) osaposa masiku 7.

Tsiku lotha ntchito

Ndizoyenera kugwiritsidwa ntchito mkati mwa zaka 2 kuyambira tsiku lopangira.

Ma Analogs a Augmentin

Ma analog a Augmentin ndi mankhwala osokoneza bongo A-Klav-Farmeks, Amoxiclav, Amoxil-KBetaclava Clavamitin, Samalirani, Teraclav.

Iliyonse mwamankhwala omwe ali pamwambapa ndi omwe Augmentin amatha kusinthidwa posakhalapo.

Mtengo wa analogues umasiyana kuchokera pa 63.65 mpaka 333.97 UAH.

Augmentin wa ana

Augmentin amagwiritsidwa ntchito kwambiri machitidwe a ana. Chifukwa chakuti ili ndi mawonekedwe a ana omasulidwa - madzi, amatha kugwiritsidwa ntchito pochiritsa ana mpaka chaka. Momwe amathandizira kulandira komanso momwe mankhwalawo amakomekera.

Kwa ana mankhwalanthawi zambiri zotchulidwa zilonda zapakhosi. Mlingo wa kuyimitsidwa kwa ana umatsimikiziridwa ndi msinkhu komanso kulemera. Mulingo woyenera kwambiri umagawidwa Mlingo wachiwiri, wofanana ndi 45 mg / kg patsiku, kapena wogawika patatu, waukulu 40 mg / kg patsiku.

Momwe mungamwe mankhwalawa kwa ana ndi kuchuluka kwa Mlingo zimatengera mtundu wa mankhwala.

Kwa ana omwe thupi lawo limaposa 40 makilogalamu, Augmentin amatchulidwa muyezo womwewo ndi odwala akulu.

Mankhwala a Augmentin a ana mpaka chaka amagwiritsidwa ntchito Mlingo wa 125 mg / 31.25 mg ndi 200 mg / 28,5 mg. Mlingo wa 400 mg / 57 mg amawonetsedwa kwa ana osaposa chaka chimodzi.

Ana omwe ali ndi zaka 6-12 (zolemera kuposa makilogalamu 19) amaloledwa kupereka kuyimitsidwa komanso Augmentin pamapiritsi. Mlingo wa mankhwala a piritsi ndi motere:

• piritsi limodzi 250 mg + 125 mg katatu patsiku,
• piritsi limodzi 500 + 125 mg kawiri patsiku (fomu iyi ya mulingo woyenera).

Ana osaposa zaka 12 amafunsidwa kumwa piritsi limodzi la 875 mg + 125 mg kawiri pa tsiku.

Kuti muyezo moyenera muyezo wa kuyimitsidwa kwa Augmentin kwa ana osaposa miyezi 3, tikulimbikitsidwa kuti mulembe madzi ndi syringe yokhala ndi chisonyezo. Kuthandizira kugwiritsidwa ntchito kwa kuyimitsidwa kwa ana osaposa zaka ziwiri, amaloledwa kuthira madzi ndi madzi muyezo wa 50/50

Ma analogu a Augmentin, omwe ali m'malo ake a pharmacological, ndi mankhwala osokoneza bongo Amoxiclav, Flemoklav Solutab, Arlet, Rapiclav, Mochulukitsa.

Kuyenderana ndi mowa

Augmentin ndi mowa ndiye kuti sikuti amatsutsana ndi mowa wa ethyl mankhwalasasintha momwe amagulitsira mankhwala.

Ngati motsutsana ndi maziko a mankhwala osokoneza bongo mukufunika kumwa mowa, ndikofunikira kutsatira ziwiri izi: kusanja komanso kuthamanga.

Kwa anthu omwe akudwala mowa, kugwiritsa ntchito mankhwalawa pamodzi ndi mowa kumatha kukhala ndi zotsatirapo zowopsa.

Kuledzeretsa mwadongosolo kumadzetsa zisokonezo zosiyanasiyana pantchito chiwindi. Odwala odwala chiwindi Malangizowo akuwonetsa kuti Augmentin akhazikitsidwe mosamala kwambiri, chifukwa zimanenedweratu momwe chiwalo chodwala chizitha kuyeserera xenobioticzovuta kwambiri.

Chifukwa chake, popewa chiopsezo chosavomerezeka, tikulimbikitsidwa kuti musamwe mowa nthawi yonse ya mankhwalawa.

Augmentin pa nthawi yoyembekezera

Monga maantibayotiki ambiri gulu la penicillin, amoxicillin, yogawidwa m'thupi lathu, imalowanso mkaka wa m'mawere. Kuphatikiza apo, zofufuza zimatha kupezeka mkaka. clavulanic acid.

Komabe, palibe vuto lililonse pakubadwa kwa mwana lomwe limadziwika. Nthawi zina, kuphatikiza clavulanic acid ndi amoxicillin zimatha kuyambitsa khanda kutsegula m'mimba ndi / kapena candidiasis (thrush) wa mucous nembanemba mkamwa.

Augmentin ali m'gulu la mankhwala omwe amaloledwa kuyamwitsa. Komabe, poyerekeza ndi momwe mayiyo amathandizira ndi Augmentin, mwana amakhala ndi zovuta zina, kuyamwitsa kuyimitsidwa.

Kafukufuku wazinyama awonetsa kuti zinthu zothandiza za Augmentin zimatha kulowa hematoplacental (GPB) chotchinga. Komabe, palibe zoyipa pakukula kwa fetal zomwe zapezeka.

Komanso, mphamvu za teratogenic sizinapezeke pakukonzekera mankhwala ndi pakamwa komanso pakamwa.

Kugwiritsa ntchito Augmentin mwa amayi apakati kungayambitse khanda lobadwa kumene necrotizing enterocolitis (NEC).

Monga mankhwala ena onse, Augmentin sakuvomerezeka kwa amayi apakati. Panthawi yoyembekezera, kugwiritsa ntchito kovomerezeka kumakhala kovomerezeka pokhapokha ngati malinga ndi mayeso a dokotala, phindu la mkazi limaposa ngozi zomwe zingakhalepo kwa mwana wake.

Ndemanga za Augmentin

Ndemanga ya mapiritsi ndi kuyimitsidwa kwa ana Augmentin gawo lalikulu zabwino. Ambiri amaganiza kuti mankhwalawa ndi mankhwala othandiza komanso odalirika.

Pamabwalo omwe anthu amagawana zomwe akumwa mankhwala ena, mankhwala ochepetsa mphamvu ya kachilombo ka HIV ndi 4,3,5,5 mwa mfundo zisanu.

Ndemanga za Augmentin osiyidwa ndi amayi a ana aang'ono zikuwonetsa kuti chida chimathandizira kuthana ndimatenda a ana monga bronchitis kapena zilonda zapakhosi. Kuphatikiza pa kugwiritsa ntchito mankhwalawa, amayi amawonanso kukoma kwake kosangalatsa, komwe ana amakonda.

Chidachi chimagwiranso ntchito pa nthawi ya pakati. Ngakhale kuti malangizowo samalimbikitsa kupereka chithandizo kwa amayi apakati (makamaka mu trimester ya 1), Augmentin nthawi zambiri amatchulidwa mu 2nd ndi 3 trimesters.

Malinga ndi madotolo, chinthu chachikulu mukamachiritsa ndi chida ichi ndikuwona kuchuluka kwa mankhwalawo ndikutsatira malingaliro onse a dokotala.

Mtengo wa Augmentin

Mtengo wa Augmentin ku Ukraine umasiyana malinga ndi mankhwala enaake.Nthawi yomweyo, mtengo wa mankhwalawo ndiwokwera pang'ono m'mafakitala ku Kiev, mapiritsi ndi manyumwa m'misika ku Donetsk, Odessa kapena Kharkov amagulitsidwa pamtengo wotsika pang'ono.

Mapiritsi a 625 mg (500 mg / 125 mg) amagulitsidwa ku malo ogulitsa mankhwala, pafupifupi, pa 83-85 UAH. Mtengo wapakati wa mapiritsi a Augmentin 875 mg / 125 mg - 125-135 UAH.

Mutha kugula maantibayotiki mu ufa wa ufa pokonzekera njira yothetsera jakisoni ndi mulingo wa 500 mg / 100 mg wa zinthu zogwiritsidwa ntchito, pafupifupi, chifukwa cha 218-225 UAH, mtengo wamba wa Augmentin 1000 mg / 200 mg - 330-354 UAH.

Mtengo wa kuyimitsidwa kwa Augmentin kwa ana:
400 mg / 57 mg (Augmentin 2) - 65 UAH,
200 mg / 28,5 mg - 59 UAH,
600 mg / 42.9 mg - 86 UAH.

Chithandizo:

Gulu la mankhwala

Gulu la Nosological (ICD-10)

Zithunzi za 3D

1 Popanga mankhwalawa, potaziyamu clavulanate amagona ndi 5% yowonjezera.

1 Madzi oyeretsedwa amachotsedwa nthawi yovala filimu.

Kufotokozera za mtundu wa kipimo

Mphamvu: yoyera kapena pafupifupi yoyera, yokhala ndi fungo labwino. Ikaphatikizidwa, kuyimitsidwa koyera kapena pafupifupi koyera kumapangidwa. Poimirira, yoyera kapena yoyera imayamba pang'onopang'ono.

Mapiritsi, 250 mg + 125 mg: yokutidwa ndi nembanemba wa filimu kuyambira yoyera mpaka pafupi yoyera, yopanda mawonekedwe, yolembedwa "AUGMENTIN" mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Mapiritsi, 500 mg + 125 mg: yokutidwa ndi chithunzi cha filimu kuyambira yoyera mpaka pafupifupi yoyera, chowongolera, cholembedwa "AC" ndikuyika pachiwopsezo mbali imodzi.

Mapiritsi, 875 mg + 125 mg: wokutidwa ndi filimu yolimba kuyambira yoyera mpaka yoyera, yoloweka mawonekedwe, yokhala ndi zilembo "A" ndi "C" mbali zonse ndi mzere wolakwika mbali imodzi. Pa kink: kuchokera pamaso achikasu mpaka oyera.

Zotsatira za pharmacological

Mankhwala

Amoxicillin ndi mankhwala osokoneza bongo owoneka bwino omwe ali ndi ntchito yolimbana ndi ma gram ambiri komanso gram alibe tizilombo. Nthawi yomweyo, amoxicillin imayamba kuwonongeka ndi beta-lactamases, chifukwa chake ntchito yokhala ndi amoxicillin sinafikira ku tizilombo tating'onoting'ono tomwe timatulutsa timadzi tambiri.

Clavulanic acid, beta-lactamase inhibitor yokhudzana ndi penicillin, amatha kuyambitsa mitundu yambiri ya beta-lactamases yomwe imapezeka mu penicillin ndi cephalosporin zosagwira tizilombo. Clavulanic acid imagwira mokwanira motsutsana ndi plasmid beta-lactamases, yomwe nthawi zambiri imayambitsa kukana kwa bakiteriya, ndipo imagwira ntchito kwambiri motsutsana ndi chromosomal beta-lactamases a mtundu woyamba, omwe saletsedwa ndi clavulanic acid.

Kupezeka kwa clavulanic acid mu Augmentin ® kukonzekera kumateteza amoxicillin kuti asawonongedwe ndi ma enzyme - beta-lactamases, omwe amalola kukulitsa mawonekedwe a antibacterial a amoxicillin.

Otsatirawa ndi ntchito yophatikiza ya amoxicillin ndi clavulanic acid mu vitro .

Bacteria imakonda kuphatikizidwa ndi amoxicillin ndi clavulanic acid

Zoyipa zamagemu: Bacillus anthracis, Enterococcus faecalis, Listeria monocytogene, Nocardia asteroides, Streptococcus spp., kuphatikiza Streptococcus pyogenes 1.2, Streptococcus agalactiae 1.2 (beta hemolytic streptococci) 1,2, Staphylococcus aureus (yokhudza methicillin) 1, Staphylococcus saprophyticus (tcheru ndi methicillin), coagulase-negative staphylococci (woganizira methicillin).

Zoyipa zaramram: Clostridium spp., Peptococcus niger, Peptostreptococcus spp., kuphatikiza Peptostreptococcus magnus, Peptostreptococcus micros.

Ma grram-negative: Bordetella pertussis, Haemophilus fuluwenza 1, Helicobacter pylori, Moraxella cafarrhalis 1, Neisseria gonorrhoeae, Pasteurella multocida, Vibrio cholerae.

Ma gram alibe ana Bacteroides spp., kuphatikiza Bacteroides fragilis, Capnocytophaga spp., Eikenella corrodens, Fusobacterium spp., kuphatikiza Fusobacterium nucleatum, Porphyromonas spp., Prevotella spp.

Zina: Borrelia burgdorferi, Leptospira icterohaemorrhagiae, Treponema pallidum.

Bacteria yomwe idayamba kukana kuphatikiza amoxicillin ndi clavulanic acid ndiyotheka

Ma grram-negative: Escherichia coli 1, Klebsiella spp., kuphatikiza Klebsiella oxetoca, Klebsiella pneumoniae 1, Proteus spp., kuphatikiza Proteus mirabilis, Proteus vulgaris, Salmonella spp., Shigella spp.

Zoyipa zamagemu: Corynebacterium spp., Enterococcus faecium, Streptococcus pneumoniae 1,2 gulu la streptococcus Viridans.

Bacteria yomwe imagwirizana mwachilengedwe pakuphatikizidwa kwa amoxicillin ndi clavulanic acid

Ma grram-negative: Acinetobacter spp., Citrobacter freundii, Enterobacter spp., Hafnia alvei, Legionella pneumophila, Morganella morganii, Providencia spp., Pseudomonas spp., Serratia spp., Stenotrophomonas maltophilia, Yersinia enterocolitica.

Zina: Chlamydia spp., kuphatikizapo Chlamydia pneumoniae, Chlamydia psittaci, Coxiella burnetii, Mycoplasma spp.

1 Kwa mabakiteriya awa, kufunikira kwakanthawi kothandizirana kwa amoxicillin ndi clavulanic acid kwawonetsedwa mu maphunziro azachipatala.

2 Zovuta za mitundu iyi ya mabakiteriya sizitulutsa beta-lactamase. Kuzindikira ndi amoxicillin monotherapy kumasonyezanso chidwi chofanana ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Pharmacokinetics

Zosakaniza zonse ziwiri za kukonzekera kwa Augmentin ® - amoxicillin ndi clavulanic acid - zimatengedwa mwachangu komanso mokwanira kuchokera m'mimba kuchokera pakamwa. Kuyamwa kwa yogwira mankhwala a Augmentin ® ndi mulingo woyenera kumwa mankhwala kumayambiriro kwa chakudya.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pamene odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga 40 mg + 10 mg / kg / tsiku la mankhwalawa Augmentin ® pamiyeso itatu, ufa woyimitsidwa pakamwa. 125 mg + 31.25 mg mu 5 ml (156.25 mg).

Magawo a pharmacokinetic oyambira

Augmentin ®, 125 mg + 31.25 mg mu 5 ml

Augmentin ®, 125 mg + 31.25 mg mu 5 ml

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa, pomwe odzipereka athanzi omwe ali ndi zaka 2 mpaka 12 pamimba yopanda kanthu amatenga Augmentin ®, ufa kuti ayimitsidwe pakamwa, 200 mg + 28,5 mg mu 5 ml (228 , 5 mg) pa mlingo wa 45 mg + 6,4 mg / kg / tsiku, logawidwa pawiri.

Magawo a pharmacokinetic oyambira

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid omwe amapezeka mu maphunziro osiyanasiyana akuwonetsedwa pansipa pamene odzipereka athanzi atatenga mlingo umodzi wa Augmentin ®, ufa kuti ayimitse pakamwa, 400 mg + 57 mg mu 5 ml (457 mg).

Magawo a pharmacokinetic oyambira

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid, omwe amapezeka m'maphunziro osiyanasiyana, pomwe odzipereka othamanga athanzi adatenga:

- 1 tabu. Augmentin ®, 250 mg + 125 mg (375 mg),

- Mapiritsi 2 Augmentin ®, 250 mg + 125 mg (375 mg),

- 1 tabu. Augmentin ®, 500 mg + 125 mg (625 mg),

- 500 mg wa amoxicillin,

- 125 mg ya clavulanic acid.

Magawo a pharmacokinetic oyambira

Amoxicillin mu kapangidwe ka mankhwala Augmentin ®

Clavulanic acid mu kapangidwe ka mankhwala Augmentin ®

Mukamagwiritsa ntchito mankhwala a Augmentin ®, kuchuluka kwa plasma kwa amoxicillin ndi ofanana ndi omwe ali ndi kamwa yokhala ndi milingo yofanana ya amoxicillin.

Ma paracokinetic magawo a amoxicillin ndi clavulanic acid, omwe amapezeka mu maphunziro osiyana, pomwe odzipereka othamanga athanzi adatenga:

- Mapiritsi 2 Augmentin ®, 875 mg + 125 mg (1000 mg).

Magawo a pharmacokinetic oyambira

Amoxicillin mu kapangidwe ka mankhwala Augmentin ®

Augmentin ®, 875 mg + 125 mg

Clavulanic acid mu kapangidwe ka mankhwala Augmentin ®

Augmentin ®, 875 mg + 125 mg

Monga iv makuphatikiza a kuphatikiza amoxicillin ndi clavulanic acid, achire poyerekeza amoxicillin ndi clavulanic acid amapezeka osiyanasiyana matupi ndi interstitial fluid (ndulu )

Amoxicillin ndi clavulanic acid ali ndi malire ofooka a mapuloteni a plasma. Kafukufuku wasonyeza kuti pafupifupi 25% ya kuchuluka kwa clavulanic acid ndi 18% ya amoxicillin m'magazi am'magazi amaphatikizika ndi mapuloteni a plasma.

Mu maphunziro a nyama, palibe chowerengera cha zigawo za kukonzekera kwa Augmentin ® mu chiwalo chilichonse chomwe chinapezeka.

Amoxicillin, monga ma penicillin ambiri, amadutsa mkaka wa m'mawere. Zotsatira za clavulanic acid zimapezekanso mkaka wa m'mawere.Kupatula kuthekera kokhala ndi matenda otsegula m'mimba ndi candidiasis pamatumbo amkamwa, palibe zovuta zina za amoxicillin ndi clavulanic acid pa thanzi la makanda oyamwitsa.

Kafukufuku wothandizira kubereka kwanyama akuwonetsa kuti amoxicillin ndi clavulanic acid amawoloka chotchinga. Komabe, palibe zoyipa zilizonse pa mwana wakhanda zomwe zapezeka.

10-25% ya koyamba mlingo wa amoxicillin amamuchotsa impso ngati anafooka metabolite (penicilloic acid). Clavulanic acid imapangidwa modabwitsa kwambiri mpaka 2,5-dihydro-4- (2-hydroxyethyl) -5-oxo-3H-pyrrole-3-carboxylic acid ndi amino-4-hydroxy-butan-2-amodzi ndipo amachotsa kudzera mu impso. Matumbo am'mimba, komanso ndi mpweya wotha ntchito mu mpweya wa kaboni.

Monga ma penicillin ena, amoxicillin amathandizidwa ndi impso, pomwe clavulanic acid imachotsedwanso ndi machitidwe a impso komanso owonjezera.

Pafupifupi 60-70% ya amoxicillin ndi 40-65% ya clavulanic acid amuchotseredwa ndi impso osasintha pakapita maola 6 mutatenga tebulo limodzi. 250 mg + 125 mg kapena piritsi limodzi 500 mg + 125 mg.

Makonzedwe omwewo a probenecid amachedwetsa kuchoka kwa amoxicillin, koma osati clavulanic acid (onani "Kuchita").

Zowonetsa Augmentin ®

Kuphatikiza kwa amoxicillin ndi clavulanic acid akuwonetsedwa kuti azichiza matenda a bakiteriya a malo otsatirawa omwe amayamba chifukwa cha tizilombo tomwe timayang'ana pakuphatikizidwa kwa amoxicillin ndi clavulanic acid:

matenda apamwamba a kupuma thirakiti (kuphatikizapo matenda a ENT), mwachitsanzo. Streptococcus pneumoniae, Haemophilus fuluwenza 1, Moraxella catarrhalis 1 ndi Streptococcus pyogene, (kupatula mapiritsi a Augmentin 250 mg / 125 mg),

matenda am'munsi kupuma, monga kufalikira kwa chifuwa, chibayo, ndi bronchopneumonia, yomwe imayamba chifukwa Streptococcus pneumoniae, Haemophilus fuluwenza 1 ndi Moraxella catarrhalis 1,

matenda amkodzo thirakiti, monga cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, nthawi zambiri amayamba chifukwa cha mitundu ya banja Enterobacteriaceae 1 (makamaka Escherichia coli 1 ), Staphylococcus saprophyticus ndi mitundu Enterococcuskomanso chinzonono choyambitsidwa ndi Nisseria gonorrhoeae 1,

khungu ndi minofu yofewa matenda omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, Streptococcus pyogene ndi mitundu Mabakiteriya 1,

matenda a mafupa ndi mafupa, monga osteomyelitis, omwe amayambitsidwa nthawi zambiri Staphylococcus aureus 1, ngati ndi kotheka, chithandizo cha nthawi yayitali ndicotheka.

matenda a odontogenic, mwachitsanzo, periodontitis, odontogenic maxillary sinusitis, mano owoneka kwambiri ndi kufalikira kwa cellulitis (piritsi la Augmentin piritsi, mlingo wa 500 mg / 125 mg, 875 mg / 125 mg),

matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (piritsi la Augmentin piritsi limodzi ndi 250 mg / 125 mg, 500 mg / 125 mg, 875 mg / 125 mg),

1 Oimira pawokha amtundu wa tizilombo tating'onoting'ono timatulutsa beta-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin (onani. Pharmacodynamics).

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin ®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira. Augmentin ® amasonyezedwanso zochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhala ndi amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa beta-lactamase, tcheru limodzi ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Contraindication

Mitundu yonse yamiyeso

Hypersensitivity kwa amoxicillin, clavulanic acid, zinthu zina za mankhwala, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,

magawo am'mbuyomu a jaundice kapena chiwindi chovuta ntchito mukamagwiritsa ntchito amoxicillin wokhala ndi clavulanic acid m'mbiri.

Kuphatikiza apo, wa ufa pakuyimitsidwa pakamwa, 125 mg + 31.25 mg

Kuphatikiza apo, ufa wotseka pakamwa, 200 mg + 28,5 mg, 400 mg + 57 mg

Matenda aimpso owonongeka (Cl creatinine osakwana 30 ml / min),

zaka za ana mpaka miyezi itatu.

Kuphatikiza pa mapiritsi okhala ndi filimu, 250 mg + 125 mg, 500 mg + 125 mg

ana ochepera zaka 12 kapena kulemera kwa thupi zosakwana 40 kg.

Kuphatikiza apo, mapiritsi okhala ndi mafilimu, 875 mg + 125 mg

Matenda aimpso owonongeka (Cl creatinine osakwana 30 ml / min),

ana ochepera zaka 12 kapena kulemera kwa thupi zosakwana 40 kg.

Ndi chisamaliro: chiwindi ntchito.

Mimba komanso kuyamwa

Mu maphunziro a ntchito za kubereka mu nyama, makamwa ndi utsogoleri wa Augmentin ® sizinayambitse zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matendawa zisanachitike, anapezeka kuti mankhwala a prophylactic ndi Augmentin ® akhoza kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis mwa akhanda. Monga mankhwala onse, Augmentin ® sayenera kuvomerezeka kuti agwiritse ntchito panthawi yomwe ali ndi pakati, pokhapokha ngati phindu lomwe mayi akuyembekezera limaposa chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin ® angagwiritsidwe ntchito poyamwa. Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amaphatikizidwa ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimachitika mu mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Zotsatira zoyipa

Zochitika zoyipa zomwe zaperekedwa pansipa zalembedwa malinga ndi kuwonongeka kwa ziwalo ndi ziwalo zamagulu ndi pafupipafupi zomwe zimachitika. Pafupipafupi pamachitika zotsatirazi: Nthawi zambiri - ≥1 / 10, nthawi zambiri ≥1 / 100 ndi ® kumayambiriro kwa chakudya, pafupipafupi - matenda am'mimba, osowa kwambiri - anti-anti-colitis (kuphatikizapo pseudomembranous colitis ndi hemorrhagic colitis, wakuda " waulesi "lilime, gastritis, stomatitis, kusintha kwa mawonekedwe a mano. Kusamalira pakamwa kumathandiza kuti mano asatulutsidwe, popeza kutsuka mano ndikokwanira.

Pa mbali ya chiwindi ndi biliary thirakiti: pafupipafupi - kuwonjezeka kwapakati pa ntchito ya AST ndi / kapena ALT. Vutoli limawonedwa mwa odwala omwe amalandira beta-lactam antiotic therapy, koma kufunikira kwake kuchipatala sikudziwika. Osowa kwambiri - hepatitis ndi cholestatic jaundice. Izi zimawonedwa mwa odwala omwe amalandira chithandizo chamankhwala a penicillin ndi cephalosporins. Kuchuluka kwa bilirubin ndi alkaline phosphatase.

Zotsatira zoyipa kuchokera ku chiwindi zimawonedwa makamaka mwa abambo ndi odwala okalamba ndipo amatha kuyanjana ndi chithandizo cha nthawi yayitali. Zochitika zoyipa izi sizimawonedwa kawirikawiri mwa ana.

Zizindikiro zolembedwa ndi zizindikiro zambiri zimachitika nthawi yotsiriza kapena itangotha, koma nthawi zina amatha kuonekera kwa milungu ingapo atamaliza kulandira chithandizo. Zochitika zoyipa nthawi zambiri zimasinthidwa. Zochitika zoyipa za chiwindi zimatha kukhala zowopsa, nthawi zina pamakhala nkhani zakufa. Pafupifupi nthawi zonse, awa anali odwala omwe ali ndi vuto lalikulu la matenda kapena odwala omwe amalandila mankhwala oopsa a hepatotoxic.

Pa khungu ndi subcutaneous minofu: pafupipafupi - zidzolo, kuyabwa, urticaria, kawirikawiri erythema multiforme, kawirikawiri Stevens-Johnson syndrome, poyizoni epermosis, oxous exfoliative dermatitis, pachimake kwambiri pantulosis.

Ngati khungu lanu siligwirizana, mankhwala a Augmentin ® ayenera kusiyidwa.

Kuchokera ku impso ndi kwamkodzo thirakiti: kawirikawiri - interstitial nephritis, crystalluria (onani "Overdose"), hematuria.

Kuchita

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin ® ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake, munthawi yomweyo kugwiritsa ntchito mankhwala a Augmentin ® ndi probenecide kungayambitse kuchuluka ndi kulimbikira kwa ndende ya magazi ya amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol.

Ma penicillin amatha kuchepetsa mayankho a methotrexate m'thupi mwa kuletsa kubisalira kwake, kotero kugwiritsa ntchito nthawi imodzi ndi gawo la Augmentin ndi methotrexate kungakulitse kuchuluka kwa methotrexate.

Monga mankhwala ena a antibacterial, kukonzekera kwa Augmentin ® kungakhudze microflora yamatumbo, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'matumbo am'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Mabukuwa amafotokoza zochitika zapafupipafupi za kuwonjezeka kwa MHO mwa odwala omwe amaphatikizana ndi acenocumarol kapena warfarin ndi amoxicillin. Ngati ndi kotheka, makonzedwe omwewo a Augmentin ® kukonzekera ndi ma PV anticoagulants kapena MHO iyenera kuyang'aniridwa mosamala popereka kapena kufalitsa kukonzekera kwa Augmentin ®; kusintha kwa mankhwalawa kwa anticoagulants pakamwa kungafunike.

Mlingo ndi makonzedwe

Mlingo wa mankhwalawa umayikidwa payekhapayekha, kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muchepetse kusokonezeka kwa m'mimba ndikuwonjezera kuyamwa, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya. Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita stepwise mankhwala (woyamba kholo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Tiyenera kukumbukira kuti 2 tabu. Augmentin ®, 250 mg + 125 mg siofanana ndi piritsi limodzi. Augmentin ®, 500 mg + 125 mg.

Akuluakulu ndi ana azaka 12 kapena kupitirira kapena masekeli 40 kapena kupitilira. Ndikulimbikitsidwa kugwiritsa ntchito 11 ml ya kuyimitsidwa pamlingo wa 400 mg + 57 mg mu 5 ml, wofanana ndi tebulo limodzi. Augmentin ®, 875 mg + 125 mg.

1 tabu. 250 mg + 125 mg katatu patsiku matenda opatsirana modekha. Mu matenda opweteka kwambiri (kuphatikiza matenda amkati ndi obwereza kwamkodzo, matenda oyamba ndi kupuma kwaposachedwa), mankhwala ena a Augmentin ® amalimbikitsidwa.

1 tabu. 500 mg + 125 mg katatu patsiku.

1 tabu. 875 mg + 125 mg kawiri pa tsiku.

Ana a zaka zitatu mpaka zaka 12 okhala ndi thupi lochepera 40 makilogalamu. Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mg / kg / tsiku kapena ml ya kuyimitsidwa. Mlingo wa tsiku ndi tsiku umagawidwa pakudya 3 tsiku lililonse kwa maola 8 aliwonse (125 mg + 31.25 mg) kapena 2 pa maola 12 aliwonse (200 mg + 28,5 mg, 400 mg + 57 mg). Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Mlingo wa Augmentin ® mlingo wa mankhwalawa kutengera amoxicillin

Mlingo wocheperako wa Augmentin ® amalimbikitsidwa zochizira matenda amkhungu ndi minyewa yofewa, komanso matendawo.

Mlingo wambiri wa Augmentin ® amalimbikitsidwa kuti azichiza matenda monga otitis media, sinusitis, matenda am'munsi kupuma komanso kwamkodzo, matenda a mafupa ndi mafupa.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsidwa ntchito kwa mankhwalawa Augmentin ® muyezo wa 40 mg + 10 mg / kg mu 3% yogawika (4: 1 kuyimitsidwa) mwa ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu. Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin ® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Makanda obadwa asanakwane. Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Magulu apadera a odwala

Odwala okalamba. Malangizo a mtundu wa mankhwalawa safunikira; Okalamba odwala mkhutu aimpso ntchito, Mlingo woyenera amamulembera odwala omwe ali ndi vuto laimpso.

Odwala omwe ali ndi vuto la chiwindi. Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti musinthe malangizowo mwa odwala.

Odwala ndi mkhutu aimpso ntchito. Kuwongolera kwa dongosolo la mankhwalawa kumadalira kuchuluka kwa mlingo wovomerezeka wa amoxicillin ndi kufunika kwa chiwonetsero cha ntchito.

Malangizo a Augmentin ®

Mapiritsi okhala ndi mafilimu, 250 mg + 125 mg: Mlingo kusintha malinga ndi pazipita mlingo wa amoxicillin.

2 tabu. 250 mg + 125 mg mu gawo limodzi maola 24 aliwonse

Pa nthawi ya dialysis, piritsi limodzi (1 piritsi) ndi piritsi limodzi. kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Mapiritsi okhala ndi mafilimu, 500 mg + 125 mg: Mlingo kusintha malinga ndi pazipita mlingo wa amoxicillin.

1 tabu. 500 mg + 125 mg mu gawo limodzi maola 24 aliwonse

Pa nthawi ya dialysis, piritsi limodzi (1 piritsi) ndi piritsi limodzi. kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Njira yokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba. Pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti mutsimikizire kuchepetsedwa kwathunthu. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pafupifupi, pafupifupi 92 ml ya madzi amafunika kukonzekera kuyimitsidwa kwa Mlingo wa 125 mg + 31.25 mg ndi 64 ml ya madzi pa mlingo wa 200 mg + 28,5 mg ndi 400 mg + 57 mg.

Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana osakwana zaka 2, muyezo umodzi wokha wa kuyimitsidwa kwa mankhwalawa a Augmentin ® akhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Bongo

Zizindikiro imatha kuwonedwa kuchokera m'matumbo am'mimba komanso kusokonezeka kwa madzi mu-electrolyte.

Amoxicillin crystalluria akufotokozedwa, nthawi zina kumabweretsa kukula kwa aimpso (onani "Maupangiri Apadera").

Kugwedezeka kwa odwala mkhutu aimpso ntchito, komanso kwa iwo amene amalandira mankhwala ambiri.

Chithandizo: Zizindikiro kuchokera m`mimba thirakiti - Symbalatic mankhwala, kulabadira mwapadera ku matenda a madzi-electrolyte bwino. Amoxicillin ndi clavulanic acid amatha kuchotsedwa m'magazi ndi hemodialysis.

Zotsatira za kafukufuku woyembekezeredwa yemwe adachitika ndi ana makumi asanu ndi limodzi m'chipinda cha poyizoni adawonetsa kuti kuyang'anira amoxicillin pamtunda wochepera 250 mg / kg sizinachititse kuti pakhale ndi zidziwitso zazikulu zakuchipatala ndipo sizinafunikire kuti pakhale thovu.

Malangizo apadera

Musanayambe chithandizo ndi Augmentin ®, ndikofunikira kusaka mbiri yakale yokhudzana ndi zam'mbuyomu zomwe zimachitika m'matumbo a penicillin, cephalosporins kapena zinthu zina zomwe zimapangitsa kuti wodwala azigwirizana.

Zoopsa komanso nthawi zina zowopsa za hypersensitivity reaction (anaphylactic reaction) ku penicillins zimafotokozedwa. Chiwopsezo chotere chimakhala chokwanira kwambiri kwa odwala omwe ali ndi mbiri ya hypersensitivity reaction ku penicillins. Ngati thupi siligwirizana, ndikofunikira kusiya mankhwala ndi Augmentin ® ndikuyamba njira zina zoyenera.

Pankhani ya zovuta za anaphylactic, epinephrine iyenera kutumizidwa mwachangu kwa wodwala. Thandizo la okosijeni, iv makonzedwe a GCS ndi kuperekedwa kwa airway patency, kuphatikizapo intubation, ingafunikenso.

Ngati akukayikira matenda opatsirana a mononucleosis, Augmentin ® sayenera kugwiritsidwa ntchito, chifukwa mwa odwala omwe ali ndi matendawa, amoxicillin angayambitse zotupa ngati khungu, zomwe zimapangitsa kuti matendawa azindikire matenda.

Kuchiza kwa nthawi yayitali ndi Augmentin ® kungayambitse kubereka kwambiri kwa tizilombo tating'onoting'ono.

Mwambiri, Augmentin ® imalekeredwa bwino ndipo imakhala ndi poizoni wambiri wa ma penicillin onse. Pa chithandizo cha nthawi yayitali ndi Augmentin ®, tikulimbikitsidwa kupenda ntchito ya impso, chiwindi ndi magazi.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya.

Odwala omwe amalandila amoxicillin ndi clavulanic acid limodzi ndi ma anticoagulants osalunjika, mwanjira zina, kuchuluka kwa PV (kuchuluka kwa MHO) kunanenedwa. Ndi kuphatikiza molunjika kwa anticoagulants osalunjika (pakamwa) osakanikirana a amoxicillin ndi clavulanic acid, kuyang'anira zisonyezo ndikofunikira. Kusungitsa kufunika kwa anticoagulants pakamwa, kusintha kwa mlingo kungafunike.

Odwala omwe ali ndi vuto la impso, mlingo wa Augmentin ® uyenera kufotokozedwa malinga ndi kuchuluka kwa kuphwanya (onani "Mlingo ndi makonzedwe", Odwala ndi mkhutu aimpso ntchito).

Odwala ochepetsedwa diuresis, crystalluria sizichitika kawirikawiri, makamaka ndi chithandizo cha makolo. Munthawi ya makonzedwe apamwamba a amoxicillin, tikulimbikitsidwa kuti timwe madzi okwanira ndikukhala ndi diursis yokwanira kuti muchepetse mapangidwe a makhwala a amoxicillin (onani "Overdose").

Kumwa mankhwalawa Augmentin ® mkati kumabweretsa zambiri mu amoxicillin mu mkodzo, zomwe zimatha kubweretsa zotsatira zabodza pakutsimikiza kwa shuga mumkodzo (mwachitsanzo, mayeso a Benedict, mayeso a Fel). Poterepa, tikulimbikitsidwa kugwiritsa ntchito njira ya glucose oxidant pofufuza kuchuluka kwa shuga mumkodzo.

Kusamalira pakamwa kumathandizira kuti khungu lisasokonekere chifukwa chomwa mankhwalawo, chifukwa ndikokwanira kutsuka mano (chifukwa chovinira).

Ndikofunikira kugwiritsa ntchito mankhwala a Augmentin ® mkati mwa masiku 30 kuyambira pomwe mutsegule phukusi la lamoni aluminiyamu (mapiritsi)

Kuzunza ndi kudalira mankhwala osokoneza bongo. Palibe kudalira mankhwala, mankhwala osokoneza bongo komanso kusinthasintha kwakukhudzana ndi kugwiritsa ntchito mankhwalawa Augmentin ®.

Kukopa pa kuyendetsa magalimoto ndi kugwira ntchito ndi njira. Popeza mankhwalawa angayambitse chizungulire, ndikofunikira kuchenjeza odwala za kusamala poyendetsa kapena kugwiritsa ntchito makina osunthira.

Kutulutsa Fomu

Ufa woyimitsidwa pakamwa, 125 mg + 31.25 mg mu 5 ml. Mu botolo lagalasi lowoneka bwino, lotsekedwa ndi screw-aluminium cap ndikuwongolera koyambira koyamba, 11.5 g 1 fl. pamodzi ndi chipewa choyezera mu chikatoni cha makatoni.

Ufa pakukonzekera kuyimitsidwa pakamwa pakamwa, 200 mg + 28,5 mg mu 5 ml, 400 mg + 57 mg mu 5 ml. Mu botolo lagalasi lowonekera lotsekeka ndi chikwapu cha aluminium choyambirira ndikutsegulira koyamba, 7.7 g (kwa mulingo wa 200 mg + 28,5 mg mu 5 ml) kapena 12,6 g (pa mulingo wa 400 mg + 57 mg mu 5 ml) ) 1 fl. pamodzi ndi chingwe choyezera kapena syringe yosungidwa mu katoni.

Mapiritsi okhala ndi mafilimu, 250 mg + 125 mg. Mu aluminium / PVC blister 10 ma PC. 1 chithuza ndi thumba la silika gel osakaniza mu phukusi la foam ya aluminiyamu. Zithunzi ziwiri zojambulidwa mumakatoni.

Mapiritsi okhala ndi mafilimu, 500 mg + 125 mg. Mu aluminium / PVC / PVDC blister 7 kapena 10 ma PC. 1 chithuza ndi thumba la silika gel osakaniza mu phukusi la foam ya aluminiyamu. 2 mapaketi a laminal zotayidwa zojambulazo mu katoni.

Mapiritsi okhala ndi mafilimu, 850 mg + 125 mg. Mu aluminium / PVC blister 7 ma PC. 1 chithuza ndi thumba la silika gel osakaniza mu phukusi la foam ya aluminiyamu. Zithunzi ziwiri zojambulidwa mumakatoni.

Tsiku lotha ntchito la Augmentin ®

makanema okhala ndi filimu 250 mg + 125 mg - zaka 2.

makanema okhala ndi filimu 500 mg + 125 mg - zaka 3.

makanema okhala ndi mafilimu 875 mg + 125 mg - zaka 3.

ufa w kuyimitsidwa pakakonzedwe kamlomo ka 125mg + 31.25mg / 5ml - zaka 2. Kuyimitsidwa okonzeka ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 200 mg + 28,5 mg / 5 ml 200 mg + 28,5 mg / 5 - 2 zaka. Kuyimitsidwa okonzeka ndi masiku 7.

ufa woyimitsidwa pakumwa kwamlomo 400 mg + 57 mg / 5 ml 400 mg + 57 mg / 5 - zaka 2. Kuyimitsidwa okonzeka ndi masiku 7.

Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Mapiritsi okhala ndi mafilimu kuyambira oyera mpaka oyera, ozungulira, olemba "AUGMENTIN" mbali imodzi, pa kink - kuyambira yoyera mpaka pafupi yoyera.

OthandiziraMagnesium stearate 6.5 mg, sodium carboxymethyl wowonda 13 mg, colloidal silicon dioxide 6,5 mg, microcrystalline cellulose 650 mg.

Zomwe zimapangidwa ndi chipolopolo: titanium dioksidi - 9.63 mg, hypromellose (5cP) - 7.39 mg, hypromellose (15cP) - 2.46 mg, macrogol 4000 - 1.46 mg, macrogol 6000 - 1.46 mg, dimethicone - 0,013 mg, madzi oyeretsedwa (ochotsedwa nthawi yopanga).

Ma PC 10 - matuza (1) ndi thumba la silika gel osakaniza - ma CD opangidwa ndi lamoni aluminiyamu zojambulazo (2) - mapaketi a makatoni.

Bacteria matenda oyambitsidwa ndi tizilombo tating'ono ta mankhwala:

Zofooka zam'mimba zopumira komanso ziwalo za ENT (mwachitsanzo, tenillitisitis, sinusitis, atitis media), zomwe nthawi zambiri zimayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae *, Moraxella catarrhalis *, Streptococcus pyogene,

- kupweteka kwam'mimba thirakiti: kukokoloka kwa chifuwa cham'mimba, chibayo ndi bronchopneumonia, yomwe nthawi zambiri imayamba chifukwa cha Streptococcus pneumoniae, Haemophilus influenzae * ndi Moraxella catarrhalis * (kupatula mapiritsi 250 mg / 125 mg),

Matenda a urogenital thirakiti: cystitis, urethritis, pyelonephritis, matenda amtundu wamkazi, omwe nthawi zambiri amayamba chifukwa cha mitundu ya banja la Enterobacteriaceae (makamaka Escherichia coli *), Staphylococcus saprophyticus ndi mitundu ya genoc Enterococcus,

- gonorrhea yoyambitsidwa ndi Neisseria gonorrhoeae * (kupatula mapiritsi 250 mg / 125 mg),

- Matenda a pakhungu ndi minofu yofewa, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, Streptococcus pyogene ndi mitundu ya mtundu wa Bacteroides *,

- matenda am'mafupa ndi mafupa: osteomyelitis, yomwe nthawi zambiri imayamba chifukwa cha Staphylococcus aureus *, ngati kuli kotheka, chithandizo cha nthawi yayitali,

- matenda a odontogenic, mwachitsanzo, periodontitis, maxillary sinusitis, zotupa zamano kwambiri ndi kufalitsa cellulite (mapiritsi 500 mg / 125 mg kapena 875 mg / 125 mg),

- matenda ena osakanikirana (mwachitsanzo, kuchotsa mimba kwa septic, sepsis ya pambuyo pake) monga gawo lamankhwala othandizira (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg).

- - Oimira pawokha a mtundu wina wa tizilombo tating'onoting'ono timatulutsa β-lactamase, yomwe imawapangitsa kuti asamve chidwi ndi amoxicillin.

Matenda oyambitsidwa ndi tizilombo tomwe timayamwa amoxicillin amatha kuthandizidwa ndi Augmentin ®, chifukwa amoxicillin ndi chimodzi mwazomwe zimagwira.Augmentin ® amasonyezedwanso ntchito yochizira matenda osakanikirana omwe amayambitsidwa ndi ma tizilombo tating'onoting'ono tokhudza amoxicillin, komanso ma tizilombo tating'onoting'ono timene timatulutsa β-lactamase, tcheru ndi kuphatikiza kwa amoxicillin ndi clavulanic acid.

Mphamvu ya mabakiteriya kuphatikiza kwa amoxicillin ndi asidi wa clavulanic amasiyanasiyana malinga ndi dera komanso nthawi. Ngati kuli kotheka, zosowa zamderalo ziyenera kukumbukiridwa. Ngati ndi kotheka, zitsanzo za tizilombo ting'onoting'onoting'ono ziyenera kusungidwa ndikuwunikiridwa kuti mumve ma bacteria.

Mlingo wa mankhwalawa umayikidwa payekha kutengera zaka, kulemera kwa thupi, impso ya wodwalayo, komanso kuopsa kwa matendawa.

Kuti muzitha kuyamwa ndikuchepetsa zotsatira zoyipa zamagetsi, Augmentin ® imalimbikitsidwa kuti idzatenge kumayambiriro kwa chakudya.

Njira yochepetsetsa ya mankhwala opha maantibayotiki ndi masiku 5.

Kuchiza sikuyenera kupitilira masiku opitilira 14 osanenapo za matenda.

Ngati ndi kotheka, n`kotheka kuchita magawo mankhwala (kumayambiriro kwa mankhwala, makolo makonzedwe a mankhwala ndi kusintha kwa m`kamwa makonzedwe).

Akuluakulu ndi ana opitirira zaka 12 kapena masekeli 40 kapena kupitilira

Piritsi limodzi la 250 mg / 125 mg katatu / tsiku (la matenda ofatsa pang'ono kapena pang'ono), kapena piritsi limodzi la 500 mg / 125 mg katatu kapena tsiku, kapena piritsi limodzi la 875 mg / 125 mg katatu / tsiku, kapena 11 ml ya kuyimitsidwa kwa 400 mg / 57 mg / 5 ml 2 nthawi / tsiku (lofanana ndi piritsi limodzi la 875 mg / 125 mg).

Mapiritsi awiri a 250 mg / 125 mg siofanana ndi piritsi limodzi la 500 mg / 125 mg.

Ana kuyambira miyezi itatu mpaka 12 wazakudya zolemera thupi zosakwana 40 kg

Mankhwalawa adapangidwira mu mawonekedwe a kuyimitsidwa pakamwa.

Kuwerengera Mlingo kumachitika malinga ndi zaka komanso kulemera kwa thupi, zomwe zimawonetsedwa mu mg / kg thupi / tsiku (kuwerengera malinga ndi amoxicillin) kapena ml ya kuyimitsidwa.

Kuchulukitsa kwa kuyimitsidwa kwa 125 mg / 31.25 mg mu 5 ml ndi katatu kapena tsiku lililonse maola 8 aliwonse.

Kuchulukitsa kwa kuyimitsidwa 200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml - 2 kawiri / tsiku lililonse maola 12.

Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Mlingo wa manambala a Augmentin ®

Mlingo wotsika wa Augmentin ® umagwiritsidwa ntchito mankhwalawa matenda a pakhungu ndi zimakhala zofewa, komanso pafupipafupi tonillitis.

Mlingo wambiri wa Augmentin ® amagwiritsidwa ntchito pochiza matenda monga atitis media, sinusitis, matendam'munsi kupuma thirakiti ndi kwamikodzo matenda a mafupa ndi mafupa.

Zosakwanira kachipatala kuti muvomereze kugwiritsa ntchito mankhwalawa Augmentin ® muyezo woposa 40 mg / kg / tsiku mu 3 3 mgawidwe wogawanika (4: 1 kuyimitsidwa) ana osakwana zaka 2.

Ana kuyambira pakubadwa mpaka miyezi itatu

Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin ® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Kugwiritsa ntchito kuyimitsidwa kwa 7: 1 (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml) sikulimbikitsidwa pagulu lino.

Ana asanakwane

Palibe malingaliro pa mtundu uliwonse wa mankhwalawo.

Odwala okalamba

Palibe kusintha kwa mlingo komwe kumafunikira. At okalamba odwala mkhutu aimpso ntchito Mlingo uyenera kusinthidwa motere kwa akulu omwe ali ndi vuto laimpso.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umachitika poganizira mfundo za QC.

Akuluakulu

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa.

Odwala a hememalysis

Kusintha kwa mankhwalawa kutengera mlingo woyenera wa amoxicillin: 2 t. 250 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena 1 tabo. 500 mg / 125 mg mu gawo limodzi maola 24 aliwonse, kapena kuyimitsidwa pa mlingo wa 15 mg / 3.75 mg / kg 1 nthawi / tsiku.

Mapiritsi pa gawo la hemodialysis, mlingo umodzi wowonjezera (piritsi limodzi) ndi wina 1 piritsi (piritsi limodzi) kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa seramu wozungulira wa amoxicillin ndi clavulanic acid).

Kuyimitsidwa musanayambe gawo la hemodialysis, muyezo wina wa 15 mg / 3.75 mg / kg uyenera kuperekedwa. Kubwezeretsa kutsata kwa magawo omwe amagwiritsidwa ntchito ndi mankhwala a Augmentin ® m'magazi, muyeso wachiwiri wa 15 mg / 3.75 mg / kg uyenera kuperekedwa pambuyo pa gawo la hemodialysis.

Odwala omwe ali ndi vuto la chiwindi

Kuchiza kumachitika mosamala; ntchito ya chiwindi imayang'aniridwa nthawi zonse. Palibe deta yokwanira kuti ikonzere kuchuluka kwa odwala mu gulu ili.

Malamulo pokonzekera kuyimitsidwa

Kuyimitsidwa kumakonzedwa nthawi yomweyo asanagwiritse ntchito koyamba.

Kuyimitsidwa (125 mg / 31.25 mg mu 5 ml): pafupifupi 60 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti muwonetsetsetsetsetsetse kuti mwatha. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 92 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwala, chipewa choyezera chiyenera kugwiritsidwa ntchito, chomwe chimayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana ochepera zaka ziwiri, muyezo umodzi wa kuyimitsidwa kwa Augmentin ® ukhoza kuchepetsedwa pakati ndi madzi.

Kuyimitsidwa (200 mg / 28,5 mg mu 5 ml kapena 400 mg / 57 mg mu 5 ml): pafupifupi 40 ml ya madzi owiritsa owiritsa kuti afundire kutentha ayenera kuwonjezeredwa ku botolo la ufa, ndiye kutseka botolo ndi chivindikiro ndikugwedeza mpaka ufa utasungunuka kwathunthu, lolani botolo kuti liyime kwa mphindi 5 kuti muwonetsetsetsetsetsetse kuti mwatha. Kenako yikani madzi pachizindikiro pa botolo ndikugwedezaninso botolo. Pazonse, pafupifupi 64 ml ya madzi amafunikira kuti ayimitse kuyimitsidwa. Botolo liyenera kugwedezedwa bwino musanagwiritse ntchito. Kuti mupeze dosing yolondola ya mankhwalawa, gwiritsani ntchito kapu kapena syringe yoyenera, yomwe imayenera kutsukidwa bwino ndi madzi mukatha kugwiritsa ntchito. Pambuyo pa kuchepetsedwa, kuyimitsidwa kuyenera kusungidwa osaposa masiku 7 mufiriji, koma osapanga chisanu.

Kwa ana ochepera zaka ziwiri, muyezo umodzi wa kuyimitsidwa kwa Augmentin ® ukhoza kuchepetsedwa ndi madzi muyezo wa 1: 1.

Zochitika zoyipa zomwe zaperekedwa pansipa zalembedwa malinga ndi kuwonongeka kwa ziwalo ndi ziwalo zamagulu ndi pafupipafupi zomwe zimachitika. Kukula kwa zochitika kumatsimikiziridwa motere: Nthawi zambiri (≥1 / 10), nthawi zambiri (≥1 / 100, ® iyenera kusiyidwa.

Kuchokera ku impso ndi kwamkodzo thirakiti: kawirikawiri - interstitial nephritis, crystalluria, hematuria.

- Hypersensitivity to amoxicillin, clavulanic acid, magawo ena a mankhwala, mankhwala a beta-lactam (mwachitsanzo, penicillins, cephalosporins) mu anamnesis,

- magawo am'mbuyomu a jaundice kapena chiwindi chovutikira mukamagwiritsa ntchito mankhwala osakanikirana a amoxicillin ndi clavulanic acid mu anamnesis,

- ana a zaka mpaka 12 ndi kulemera kwa thupi kosakwana 40 kg (mapiritsi 250 mg / 125 mg kapena 500 mg / 125 mg, kapena 875 mg / 125 mg),

- ana a zaka mpaka miyezi itatu (ufa wopangira kuyimitsidwa kwa makonzedwe amkamwa a 200 mg / 28,5 mg ndi 400 mg / 57 mg),

- kuwonongeka kwaimpso (CC ≤ 30 ml / mphindi) - (mapiritsi 875 mg / 125 mg, pa ufa w kuyimitsidwa pakumwa kwamlomo 200 mg / 28,5 mg ndi 400 mg / 57 mg),

- phenylketonuria (ufa wowimitsa pakumwa pakamwa).

Ndi chenjezo: chiwindi ntchito.

Mu maphunziro a ntchito yolereka mu nyama, makamwa ndi utsogoleri wa Augmentin ® sizinayambitse zotsatira za teratogenic.

Pa kafukufuku m'modzi mwa azimayi omwe ali ndi matuza kusanachitike, anapezeka kuti mankhwala a prophylactic amatha kuphatikizidwa ndi chiopsezo chowonjezeka cha necrotizing enterocolitis akhanda.Monga mankhwala onse, Augmentin ® siyikulimbikitsidwa kuti mugwiritse ntchito panthawi yomwe muli ndi pakati, pokhapokha ngati phindu lomwe likuyembekezeredwa kwa mayi limaposa chiwopsezo cha mwana wosabadwayo.

Mankhwala Augmentin ® angagwiritsidwe ntchito poyamwa. Kupatula kuti mwina mungayambitse matenda otsegula m'mimba kapena maselo a mucous nembanemba amkamwa omwe amaphatikizidwa ndi kulowetsedwa kwa kuchuluka kwa zinthu zomwe zimachitika mu mankhwalawa mkaka wa m'mawere, palibe zovuta zina zomwe zidawonedwa mu makanda oyamwa. Pakakhala zovuta m'makanda oyamwitsa, kuyamwitsa kuyenera kusiyidwa.

Odwala ndi mkhutu aimpso ntchito

Kusintha kwa dose kumakhazikitsidwa ndi mlingo woyenera wambiri wa amoxicillin ndipo umachitika poganizira mfundo za QC.

Akuluakulu

Nthawi zambiri, ngati kuli kotheka, chithandizo cha makolo chiyenera kukondedwa.

Akuluakulu ndi ana opitirira zaka 12 kapena masekeli oposa 40 makilogalamu pa hemodialysis

Kusintha kwa Mlingo wokhazikika pazotsatira zoyenera za amoxicillin: 1 t. 500 mg + 125 mg mu gawo limodzi maola 24 aliwonse kapena mapiritsi awiri. 250 mg / 125 mg mu mlingo umodzi maola 24 aliwonse, kapena 500 mg / 125 mg (20 ml ya kuyimitsidwa pa mlingo wa 125 mg / 31.25 mg mu 5 ml) 1 nthawi / tsiku.

Pa gawo la dialysis, gawo limodzi la piritsi 1 (piritsi limodzi) ndi piritsi lina kumapeto kwa gawo la dialysis (kulipirira kuchepa kwa kuchuluka kwa seramu ya amoxicillin ndi clavulanic acid).

Ana osakwana zaka 12

Mankhwalawa adapangidwira mu mawonekedwe a kuyimitsidwa pakamwa.

Kuwerengera kwa mankhwalawa kumachitika molingana ndi zaka komanso kulemera, zomwe zikuwonetsedwa mu mg / kg ya kulemera kwa thupi patsiku (kuwerengetsa malinga ndi amoxicillin) kapena mamililita a kuyimitsidwa.

Ana olemera 40 kg kapena kupitirira Mlingo womwewo womwe akulu ayenera kutumikiridwa.

Ana kuyambira pakubadwa mpaka miyezi itatu. Chifukwa cha kusakhazikika kwa mawonekedwe a impso, mlingo woyenera wa Augmentin ® (kuwerengera amoxicillin) ndi 30 mg / kg / tsiku mu 2 waukulu magawo a 4: 1.

Kugwiritsa ntchito kuyimitsidwa kwa 7: 1 mwa anthuwa sikulimbikitsidwa.

Ana a zaka 3 mpaka 12 zaka. Mlingo woyeserera komanso kuchuluka kwa makonzedwe akufotokozedwa pansipa.

Mlingo wa manambala a Augmentin ®

Mlingo wotsika wa Augmentin ® umagwiritsidwa ntchito mankhwalawa matenda a pakhungu ndi zimakhala zofewa, komanso pafupipafupi tonillitis.

Mlingo wambiri wa Augmentin ® amagwiritsidwa ntchito pochiza matenda monga atitis media, sinusitis, matendam'munsi kupuma thirakiti ndi kwamikodzo.

Palibe chidziwitso chokwanira cha chipatala cholimbikitsa kugwiritsa ntchito mankhwalawa Augmentin ® muyezo wa 40 mg / kg / tsiku mu 3 Mlingo wogawika (4: 1 kuyimitsidwa) kapena 45 mg / kg / tsiku mu 2-mgawo wogawanika (7: 1 kuyimitsidwa) ana osakwana zaka 2.

Musanayambe chithandizo ndi Augmentin ®, ndikofunikira kusaka mbiri yakale yokhudzana ndi zam'mbuyomu zomwe zimapangitsa kuti penicillins, cephalosporins kapena allergen ena adwala.

Zowopsa, ndipo nthawi zina zakupha, hypersensitivity reaction (anaphylactic reaction) ku penicillins amafotokozedwa. Chiwopsezo chotere chimakhala chokwanira kwambiri kwa odwala omwe ali ndi mbiri ya hypersensitivity reaction ku penicillins. Ngati thupi siligwirizana, ndikofunikira kusiya mankhwala ndi Augmentin ® ndikuyamba njira zina zoyenera. Pankhani ya vuto lalikulu la hypersensitivity, epinephrine iyenera kutumikiridwa nthawi yomweyo. Thandizo la okosijeni, iv makonzedwe a GCS ndi kuperekedwa kwa airway patency, kuphatikizapo intubation, ingafunikenso.

Kukhazikitsidwa kwa mankhwalawa Augmentin ® sikulimbikitsidwa ngati anthu akuganiza kuti ali ndi matenda opatsirana, chifukwa odwala omwe ali ndi matendawa, amoxicillin angayambitse matenda oopsa a matendawa, omwe amachititsa kuti matenda adziwe.

Kuchiza kwa nthawi yayitali ndi Augmentin ® nthawi zina kumabweretsa kubalanso kwakukulu kwa tizilombo tating'onoting'ono.

Mwambiri, Augmentin ® imalekeredwa bwino ndipo imakhala ndi poizoni wambiri wa ma penicillin onse.

Pa chithandizo cha nthawi yayitali ndi Augmentin ®, tikulimbikitsidwa kupenda ntchito ya impso, chiwindi ndi magazi.

Pofuna kuchepetsa chiwopsezo cha mavuto obwera kuchokera m'matumbo am'mimba, mankhwalawa ayenera kumwedwa kumayambiriro kwa chakudya.

Odwala omwe amalandila amoxicillin ndi clavulanic acid limodzi ndi ma anticoagulants osalunjika, nthawi zina, kuchuluka kwa prothrombin nthawi (kuwonjezeka kwa MHO) kunanenedwa. Ndi kuphatikiza molunjika kwa anticoagulants osalunjika (pakamwa) osakanikirana a amoxicillin ndi clavulanic acid, kuyang'anira zisonyezo ndikofunikira. Kusungitsa kufunika kwa anticoagulants pakamwa, kusintha kwa mlingo kungafunike.

Odwala omwe ali ndi vuto laimpso, mlingo wa Augmentin ® uyenera kuchepetsedwa.

Odwala ndi kuchepetsedwa diuresis, nthawi zina, chitukuko cha crystalluria chimanenedwa, makamaka ndi kugwiritsidwa ntchito kwa mankhwala ndi ababa. Munthawi ya makonzedwe apamwamba a amoxicillin, tikulimbikitsidwa kuti timwe madzi okwanira ndikukhala ndi diursis yokwanira kuti muchepetse mapangidwe a makhwala a amoxicillin.

Kumwa mankhwalawa Augmentin ® mkati kumabweretsa zambiri mu amoxicillin mu mkodzo, zomwe zimatha kubweretsa zotsatira zabodza pakukhazikika kwa shuga mumkodzo (mwachitsanzo, mayeso a Benedict, mayeso a Feling). Poterepa, tikulimbikitsidwa kugwiritsa ntchito njira ya glucose oxidant pofufuza kuchuluka kwa shuga mumkodzo.

Kusamalira pakamwa kumathandiza kuti mano asatulutsidwe, popeza kutsuka mano ndikokwanira.

Mapiritsi ayenera kugwiritsidwa ntchito mkati mwa masiku 30 kuyambira pomwe mutsegule phukusi la lameled aluminium.

Kuzunza ndi kudalira mankhwala osokoneza bongo

Palibe kudalira mankhwala, mankhwala osokoneza bongo komanso kusinthasintha kwakukhudzana ndi kugwiritsa ntchito mankhwalawa Augmentin ®.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Popeza mankhwalawa angayambitse chizungulire, ndikofunikira kuchenjeza odwala za kusamala poyendetsa kapena kugwiritsa ntchito makina osunthira.

Zizindikiro Zizindikiro zam'mimba komanso kusowa kwa madzi m'magetsi kumatha kuchitika. Amoxicillin crystalluria akufotokozedwa, nthawi zina kumabweretsa kukula kwa aimpso.

Convulsions amatha kuchitika kwa odwala mkhutu aimpso ntchito, komanso kwa iwo omwe amalandira kuchuluka kwa mankhwalawa.

Chithandizo: Matumbo am'mimba - chidziwitso cha mankhwala, makamaka pokhudzana ndi kusintha kwa mawonekedwe a madzi-electrolyte. Ngati bongo, amoxicillin ndi clavulanic acid amatha kuchotsedwa m'magazi ndi hemodialysis.

Zotsatira za kafukufuku woyembekezeredwa yemwe adachitika ndi ana 51 kumalo operekera poizoni adawonetsa kuti kuyang'anira amoxicillin pamlingo wochepera 250 mg / kg sizinachititse kuti pakhale ndi zidziwitso zazikulu zakuchipatala ndipo sizinafune kuti pakhale chiphuphu.

Kugwiritsa ntchito munthawi yomweyo mankhwala a Augmentin ® ndi phenenecid osavomerezeka. Probenecid imachepetsa katulutsidwe katulutsidwe ka amoxicillin, chifukwa chake, munthawi yomweyo kugwiritsa ntchito mankhwala a Augmentin ® ndi probenecide kungayambitse kuchuluka ndi kulimbikira kwa ndende ya magazi ya amoxicillin, koma osati clavulanic acid.

Kugwiritsa ntchito munthawi yomweyo allopurinol ndi amoxicillin kungakulitse chiopsezo cha khungu losokonezeka. Pakadali pano, palibe zambiri m'mabuku zomwe zimagwiritsidwa ntchito nthawi imodzi yophatikizira amoxicillin ndi clavulanic acid ndi allopurinol.

Ma penicillin amatha kuchepetsa mayankho a methotrexate m'thupi mwa kuletsa kubisalira kwake, chifukwa chake, kugwiritsa ntchito mankhwalawa Augmentin ® ndi methotrexate kungakulitse chiwopsezo cha methotrexate.

Monga mankhwala ena a antibacterial, kukonzekera kwa Augmentin ® kungakhudze microflora yamatumbo, zomwe zimayambitsa kuchepa kwa mayamwidwe a estrogen kuchokera m'matumbo am'mimba komanso kuchepa kwa magwiridwe antchito opatsirana pakamwa.

Mabukuwa amafotokoza zochitika zapafupipafupi za kuwonjezeka kwa MHO mwa odwala omwe amaphatikizana ndi acenocumarol kapena warfarin ndi amoxicillin. Ngati pakufunika kutumiza nthawi yomweyo Augmentin ® ndi anticoagulants, nthawi ya prothrombin kapena MHO iyenera kuyang'aniridwa mosamala popereka kapena kuletsa Augmentin ®, kusintha kwa anticoagulants pakamwa kungafunike.

Mankhwala ndi mankhwala.

Mankhwalawa amayenera kusungidwa m'malo owuma osapezekapo kwa ana pa kutentha osaposa 25 ° C. Alumali moyo wamapiritsi (250 mg + 125 mg) ndi (875 mg + 125 mg) ndi zaka 2, ndipo mapiritsi (500 mg + 125 mg) ndi zaka zitatu. Moyo wa alumali wa ufa pokonzekera kuyimitsidwa mu botolo losatsimikizika ndi zaka ziwiri.

Kuyimitsidwa okonzekeraku kuyenera kusungidwa mufiriji pamtunda wa 2 ° mpaka 8 ° C kwa masiku 7.

Mukalandira mankhwala kuchipatala, mankhwalawo atha kupemphedwa kuti akupatseni mankhwala!