Liptonorm: malangizo, ntchito, analogi, mtengo, ndemanga

Nambala yolembetsa: P No. 016155/01

Zina zamalonda zamankhwala: Liptonorm®

Dzinalo Lopanda Padziko Lonse: Atorvastatin

Mlingo: mapiritsi okutira

Kupanga

Piritsi lililonse lophimba limakhala ndi:
Zogwira ntchito - calcium wa Atorvastatin, wofanana ndi 10 mg ndi 20 mg ya atorvastatin
Othandizira: calcium carbonate, microcrystalline cellulose, lactose, pakati 80, hydroxypropyl cellulose, crossscarmellose, magnesium stearate, hydroxypropyl methyl cellulose, titanium dioxide, polyethylene glycol.

Kufotokozera

Mapiritsi oyera, ozungulira, a biconvex. Pa nthawi yopuma, miyala ndi yoyera kapena pafupifupi yoyera.

Gulu la Pharmacotherapeutic: lipid-kutsitsa wothandizila - choletsa wa HMG CoA reductase.

ATX CODE S10AA05

Mankhwala

Mankhwala
Hypolipidemic wothandizila kuchokera pagulu la statins. Njira yayikulu yogwirira ntchito ya atorvastatin ndikulepheretsa zochitika za 3-hydroxy-3-methylglutaryl coenzyme A - (HMG-CoA) reductase, enzyme yomwe imathandizira kusintha kwa HMG-CoA kukhala mevalonic acid. Kusintha uku ndi limodzi mwamagawo oyambira mu cholesterol synthesis mu thupi. Kupsinjika kwa atorvastatin cholesterol synthesis kumabweretsa kuwonjezereka kwa LDL receptors (otsika kachulukidwe lipoproteins) mu chiwindi, komanso mu minyewa yowonjezera. Ma receptor amenewa amamanga tinthu tating'onoting'ono ta LDL ndikuwachotsa m'madzi a m'magazi, zomwe zimapangitsa kuti magazi a LDL atsike.
Mphamvu ya antisulinotic ya atorvastatin ndi chifukwa cha zotsatira za mankhwala pazitseko zamitsempha yamagazi ndi zigawo zamagazi. Mankhwala tikulephera kaphatikizidwe isoprenoids, omwe ali zinthu kukula kwa mkati mwa mtsempha wamagazi. Mothandizidwa ndi atorvastatin, kukula kwa kudalira kwa endothelium kumayenda bwino. Atorvastatin amatsitsa cholesterol, otsika kachulukidwe lipoprotein, apolipoprotein B, triglycerides. Zimayambitsa kuwonjezeka kwa cholesterol ya HDL (ma dipoproteins apamwamba) ndi apolipoprotein A.
Kuchita kwa mankhwalawa, monga lamulo, kumachitika pakatha milungu iwiri ya makonzedwe, ndipo mphamvu yakeyo imatheka patadutsa milungu inayi.

Pharmacokinetics
Mafuta ndi okwera. Nthawi yofika kwambiri ndende ndi maola 1-2, kuchuluka kwambiri kwa azimayi ndi 20% kuposa, AUC (dera lomwe ili pansi pajika) ndi 10%, kutsika kwambiri kwa odwala omwe ali ndi vuto la zakumwa zoledzeretsa ndi nthawi 16, Auc ndi 11 kuposa momwe amagwirira. Kudya pang'ono kumachepetsa kuthamanga ndi kutalika kwa mankhwalawa (mwa 25% ndi 9%, motsatana), koma kuchepa kwa cholesterol ya LDL kuli chimodzimodzi ndi kugwiritsidwa ntchito kwa atorvastatin popanda chakudya. Kuchulukitsidwa kwa atorvastatin pamene ntchito madzulo kumatsika kuposa m'mawa (pafupifupi 30%). Ubale wapakati pakati pa kuchuluka kwa mayamwidwe ndi mlingo wa mankhwalawo unawululidwa.
Bioavailability - 14%, zokhudza bioavailability wa zoletsa ntchito motsutsana HMG-CoA reductase - 30%. Kutsika kwachilengedwe kwa bioavailability kumachitika chifukwa cha kagayidwe kachakudya ka mucous membrane wa m'mimba ndipo mkati mwa "gawo loyamba" kudzera pachiwindi.
Kuchulukitsa kwapakati kumagawa ndi 381 l, kulumikizana ndi mapuloteni amadzi a m'magazi ndi 98%.
Amapangidwa makamaka mu chiwindi mothandizidwa ndi cytochrome P450 CYP3A4, CYP3A5 ndi CYP3A7 ndikupanga ma metabolac yogwira metabolites (ortho- ndi para-hydroxylated, mankhwala a beta-oxidation).
Mphamvu yoletsa kukonzekera kwa mankhwala oletsa HMG-CoA reductase ndi pafupifupi 70% yotsimikizika ndi ntchito yozungulira metabolites.
Imafukusidwa mu ndulu pambuyo pakuchepa kwa hepatic ndi / kapena metabolism yowonjezera (sikuti imayambiranso kwambiri).
Hafu ya moyo ndi maola 14. Ntchito ya inhibitory motsutsana ndi HMG-CoA reductase imangokhalira pafupifupi maola 20-30, chifukwa cha kukhalapo kwa metabolites yogwira. Osakwana 2% ya mlingo wa pakamwa amadziwika mu mkodzo.
Sichotsetsedweratu pa hemodialysis.

Zizindikiro zogwiritsidwa ntchito

Hypercholesterolemia yoyamba, zosakanizira zophatikizika, heterozygous ndi homozygous banja hypercholesterolemia (monga chowonjezera pachakudya).

Hypersensitivity aliyense mwa zigawo zina za mankhwala, matenda a chiwindi mu gawo yogwira (kuphatikizapo yogwira hepatitis, matenda oopsa a hepatitis), kuchuluka kwa hepatic transaminases (nthawi zopitilira katatu poyerekeza ndi malire apamwamba) achikhalidwe osadziwika, kulephera kwa chiwindi (kuopsa kwa A ndi B malinga ndi dongosolo la Mwana-Pyug), matenda ena amisempha, mimba, mkaka wa zaka, mpaka zaka 18 (kuchita bwino ndi chitetezo sizinakhazikitsidwe).

Ndi chisamaliro: mbiri ya matenda a chiwindi, kusokonekera kwambiri kwa electrolyte, endocrine ndi matenda a metabolic, uchidakwa, matenda oopsa, matenda oopsa (sepsis), kugwirira kosalamulirika, opaleshoni yayikulu, kuvulala.

Mlingo ndi makonzedwe

Asanayambe chithandizo ndi Liptonorm, wodwalayo ayenera kusinthidwa ku chakudya chomwe chimatsimikizira kuchepa kwa magazi lipids, omwe amayenera kuonedwa pakumwa mankhwala.
Mkati, tengani nthawi iliyonse masana (koma nthawi yomweyo), osasamala za chakudya.
Mlingo woyambira wabwino ndi 10 mg kamodzi patsiku. Kenako, mlingo umasankhidwa payekha kutengera zomwe zili mu cholesterol - LDL. Mlingo uyenera kusinthidwa pakapita milungu inayi. Pazipita tsiku lililonse 80 mg mu 1 mlingo.

Hypercholegous cholowa ndi polygenic) hypercholesterolemia (mtundu IIa) ndi hyperlipidemia wosakanikirana (mtundu IIb)
Chithandizo chimayamba ndi koyamba mlingo woyenera, womwe umachulukitsidwa pambuyo pa milungu 4 ya chithandizo, kutengera momwe wodwalayo amayankhira. Mlingo wapamwamba tsiku lililonse ndi 80 mg.

Homozygous cholowa hypercholesterolemia
Mulingo wofanana ndi mitundu ina ya hyperlipidemia. Mlingo woyambirira amasankhidwa payekha kutengera kuopsa kwa matendawa. Odwala ambiri omwe ali ndi homozygous cholowa hypercholesterolemia, zotsatira zoyenera zimawonedwa pogwiritsa ntchito mankhwala tsiku lililonse 80 mg (kamodzi).

Odwala omwe ali ndi vuto la impso komanso okalamba, kusintha kwa Liptonorm sikofunikira.
Odwala omwe ali ndi vuto la chiwindi, ayenera kusamala pokhudzana ndi kuchepa kwa mankhwalawa. Magawo a chipatala ndi a labotale ayenera kuyang'aniridwa mosamala, ndipo ngati kusintha kwakukulu kwa matenda kwakapezeka, mulingo uyenera kuchepetsedwa kapena chithandizo chitha.

Kuchokera ku dongosolo lamanjenje lalikulu: zopitilira 2% milandu - kusowa tulo, chizungulire, osakwana 2% ya milandu - mutu, asthenic syndrome, malaise, kugona, maliseche, amisia, kupsinjika kwamitsempha, kupweteka kwamitsempha yam'maso, matenda amisala, kukhumudwa kupsinjika.
Kuchokera pamalingaliro: amblyopia, ikulira m'makutu, kuwuma kwa conjunctiva, kusokonezeka kwa malo okhala, kutuluka kwa magazi m'maso, kugontha, glaucoma, parosmia, kuchepera kwa kukoma, kupotoza kwa kukoma.
Kuchokera pamtima: m'malo opitilira 2% - kupweteka pachifuwa, osakwana 2% - palpitations, vasodilation, migraines, hypotension postural, kuthamanga kwa magazi, phlebitis, arrhythmia, angina pectoris.
Kuchokera ku hemopoietic system: anemia, lymphadenopathy, thrombocytopenia.
Kuchokera pakapumidwe: zopitilira 2% milandu - bronchitis, rhinitis, osakwana 2% milandu - chibayo, dyspnea, mphumu ya bronchial, nosebleeds.
Kuchokera m'mimba: zopitilira 2% milandu - nseru, kutentha mtima, kudzimbidwa, matenda am'mimba, kupweteka kwam'mimba, kupweteka kwam'mimba, kugona kapena pakamwa, kupweteka pakamwa, kupindika, kukomoka, kusanza, kuchepa kwamatumbo, esophagitis, glossitis, zotupa ndi zilonda zam'mimba za mucous. pakamwa, gastroenteritis, hepatitis, hepatic colic, cheilitis, duodenal chilonda, kapamba, cholestatic jaundice, kuphwanya chiwindi ntchito, magazi amitsempha, melena, magazi m`kamwa, tenesmus.
Kuchokera ku minculoskeletal system: zopitilira 2% milandu - nyamakazi, osakwana 2% milandu - mwendo kukokana, bursitis, tendosynovitis, myositis, myopathy, arthralgia, myalgia, rhabdomyolysis, torticollis, minofu hypertonicity, kuphatikizira kwapakati.
Kuchokera ku genitourinary system: kuposerapo 2% ya milandu - matenda a urogenital, edema yocheperako, 2% ya milandu - dysuria (kuphatikizapo polakiuria, nocturia, kuchepa kwamkodzo kapena kusungika kwamkodzo, kuvomerezera kukodza), nephritis, hematuria, kutuluka kwa maliseche, nephrourolithiasis, metrorrhagia, epididymitis, kuchepa kwa libido, kusabala, kusokonezeka kwamphamvu.
Pa khungu: osakwana 2% ya milandu - alopecia, xeroderma, kuchuluka thukuta, chikanga, seborrhea, ecchymosis, petechiae.
Zotsatira zoyipa: osachepera 2% ya milandu - kuyabwa, zotupa pakhungu, kukhudzana ndi khungu, kawirikawiri - urticaria, angioedema, nkhope edema, photosensitivity, anaphylaxis, erythema multiforme, Stevens-Johnson syndrome, poyizoni epermermal necrolysis (matenda a Lyell).
Zizindikiro zasayansi: osakwana 2% a milandu ndi hyperglycemia, hypoglycemia, kuchuluka kwa serum creatine phosphokinase, alkaline phosphatase, albuminuria, kuchuluka kwa alanine aminotransferase (ALT) kapena aspartic aminotransferase.
Zina: osakwana 2% ya milandu - kulemera, gynecomastia, mastodynia, kuchuluka kwa gout.

Bongo

Chithandizo: palibe mankhwala enieni. Chithandizo cha Syndrome chimachitika. Amachitapo kanthu kuti azigwira ntchito zofunikira za thupi ndikuwathandiza kupewa kuthana ndi mankhwalawa: kupweteka kwam'mimba, kudya makala ogwidwa. Hemodialysis siyothandiza.
Ngati pali zizindikiro ndi kukhalapo kwa zinthu zoyambitsa chitukuko chaimpso chifukwa cha rhabdomyolysis (njira yocheperako koma yoopsa), mankhwalawo ayenera kusiyidwa.
Popeza atorvastatin imagwirizanitsidwa kwambiri ndi mapuloteni a plasma, hemodialysis ndi njira yosagwira ntchito yochotsa chinthuchi m'thupi.

Kuchita ndi mankhwala ena

Ndi munthawi yomweyo makonzedwe a cyclosporine, fibrate, erythromycin, clarithromycin, immunosuppressive, antifungal mankhwala (okhudzana ndi azoles) ndi nicotinamide, kuchuluka kwa atorvastatin m'madzi a m'magazi (komanso chiopsezo cha myopathy) chikuwonjezeka. Maantacidids amachepetsa ndende ndi 35% (zotsatira za LDL cholesterol sizisintha).
Kugwiritsa ntchito pamodzi kwa atorvastatin ndi ma proteinase inhibitors omwe amadziwika kuti cytochrome P450 CYP3A4 inhibitors akuphatikizidwa ndi kuwonjezeka kwa plasma mozungulira kwa atorvastatin.
Mukamagwiritsa ntchito digoxin osakanikirana ndi atorvastatin pa mlingo wa 80 mg / tsiku, kuchuluka kwa digoxin kumawonjezera pafupifupi 20%.
Kuchulukitsa ndende ndi 20% (akapatsidwa mankhwala a atorvastatin pa 80 mg / tsiku) la mankhwala amkamwa okhala ndi norethindrone ndi ethinyl estradiol.
Mphamvu yokhala ndi lipid yotsitsa kuphatikiza ndi colestipol imaposa izi kwa aliyense pamankhwala.
Ndi makonzedwe munthawi yomweyo ndi warfarin, nthawi ya prothrombin imachepa m'masiku oyamba, komabe, patatha masiku 15, chizindikiro ichi chimasintha. Pankhaniyi, odwala omwe atorvastatin omwe ali ndi warfarin ayenera kukhala ochulukirapo kuposa masiku onse pakuwongolera nthawi ya prothrombin.
Kugwiritsa ntchito madzi a mphesa nthawi ya mankhwala ndi atorvastatin kungayambitse kuchuluka kwa mankhwalawa m'madzi a m'magazi. Mwakutero, odwala omwe amamwa mankhwalawa ayenera kupewa kumwa izi.

Malangizo apadera

Kuwonongeka kwa chiwindi
Kugwiritsa ntchito ma HMG-CoA reductase inhibitors kuti muchepetse lipids zamagazi kungapangitse kusintha kwa magawo amomwe amomwe amachititsa ntchito ya chiwindi.
Kuchita kwa chiwindi kuyenera kuyang'aniridwa musanalandire chithandizo, masabata 6, masabata 12 mutangoyamba Liptonorm komanso pambuyo poti kuchuluka kulikonse kwa mankhwalawa, mwachitsanzo, miyezi isanu ndi umodzi iliyonse. Kusintha kwa zochitika za ma enzymes a chiwindi nthawi zambiri kumawonedwa miyezi itatu yoyambirira atatha kumwa Liptonorm. Odwala omwe ali ndi kuchuluka kwa transaminase ayenera kuwunikidwa mpaka milingo ya enzyme ibwerere ku yachilendo. Ngati mfundo za alanine aminotransferase (ALT) kapena aspartic aminotransferase (AST) ndizochulukirapo koposa katatu kuposa momwe mulili wovomerezeka, tikulimbikitsidwa kuti muchepetse muyeso wa Liptonorm kapena muimire chithandizo.

Chifupa
Odwala omwe ali ndi myalgia, kufooka kapena kufooka kwa minofu ndi / kapena kuwonjezeka kwakukulu kwa KFK kumaimira gulu lowopsa chifukwa chotupa cha myopathy (chofotokozedwa ngati kupweteka kwa minofu ndi kuwonjezeka kofananira kwa KFK nthawi zopitilira 10 poyerekeza ndi malire apamwamba).
Mukamapereka mankhwala othandizira a Liptonorm ndi cyclosporine, zotumphukira za fibric acid, erythromycin, clarithromycin, immunosuppressants, ndi mankhwala antifungal a kapangidwe ka azole, komanso mulingo wa niacin womwe umayambitsa kuchepa kwa milingo ya lipid, ndikofunikira kufananizira zabwino zomwe zingachitike komanso kuchuluka kwa chiwopsezo ndi mankhwalawa. Zizindikiro kapena kupweteka kwa minofu, kufoka kapena kufooka kumawonekera, makamaka m'miyezi yoyambirira ya chithandizo komanso kuwonjezeka kwa mankhwala aliwonse Reparata.

Kuchiza ndi Liptonorm kuyenera kuyimitsidwa kwakanthawi kapena kusiya ngati vuto lalikulu layamba chifukwa cha myopathy, komanso ngati pali zovuta zomwe zingayambike chifukwa cha kulephera kwa impso chifukwa cha rhabdomyolysis (mwachitsanzo, matenda oopsa, kuvulala kwamizere, kuchitidwa opaleshoni yayikulu, kuvulala kwambiri, zovuta za metabolic ndi endocrine, komanso kusalinganika kwa electrolyte).
Mwa azimayi amsinkhu wobereka omwe sagwiritsa ntchito njira zodalirika zakulera, kugwiritsa ntchito Liptonorm sikulimbikitsidwa. Ngati wodwala akukonzekera kutenga pakati, ayenera kusiya kumwa Liptonorm osachepera mwezi umodzi asanakonzekere kutenga pakati.
Wodwalayo ayenera kufunsa dokotala nthawi yomweyo ngati ululu wosaneneka kapena kufooka kwa minofu kumachitika, makamaka ngati akuphatikizidwa ndi malaise ndi malungo.

Kukopa pa kuyendetsa galimoto ndikugwira ntchito ndi zinthu

Zotsatira zoyipa za Liptonorm pakutha kuyendetsa galimoto ndikugwira ntchito ndi zida zomwe zimafunikira chidwi chochulukirapo sizinalembedwe.

Kutulutsa Fomu

Mapiritsi okhala ndi 10 mg ndi 20 mg.
Pa mapiritsi 7, 10 kapena 14 mu matuza a Al / PVC.
1, 2, 3, 4 matuza mu kakhadikhadi komatoni pamodzi ndi malangizo ogwiritsa ntchito.

Malo osungira

Lembani B. M'dera louma, lamdima lotentha kwambiri mpaka 25 ° C.
Pewani kufikira ana.

Tsiku lotha ntchito

Zaka 2 Osagwiritsa ntchito tsiku lotha ntchito likusonyezedwa pa phukusi.

Mankhwala Okhala Pamalo a Pharmacy

Wopanga:
"M.J. Biopharm", India
113 Jolly Maker Chambers-II, Nariman Point, Mumbai 400021, India
Tele: 91-22-202-0644 Fakisi: 91-22-204-8030 / 31

Zoyimira ku Russian Federation
119334 Russia, Moscow, ul. Kosygina, 15 (GC Orlyonok), ofesi 830-832

Atanyamula:
Pharmstandard - Leksredstva OJSC
305022, Russia, Kursk, ul. 2 Aggregate, 1a / 18.
Tele / Fakisi: (07122) 6-14-65

Kuphatikizika, mawonekedwe omasulidwa

Katundu wogwira wa Liptonorm ndi atorvastatin. Zimaphatikizidwa ndi zinthu zothandizira: calcium carbonate, cellulose, mkaka, hydroxypropyl cellulose, croscarmellose, magnesium stearate, titanium dioxide, polyethylene glycol.

Liptonorm ndi piritsi loyera, lozungulira, loyera. Pali mitundu iwiri ya mankhwala omwe ali ndi yogwira pazinthu 10 kapena 20 mg.

Zotsatira za pharmacological

Atorvastatin ndi HMG-CoA reductase inhibitor. Enzyme iyi ndiyofunikira kuti thupi lipange cholesterol. Molekyulu ya Liptonorm ndi yofanana mu mawonekedwe ake. Maselo a chiwindi amatenga enzyme, kuphatikiza pakupanga kwa cholesterol - imayima. Kupatula apo, zinthu za atorvastatin sizofanana ndi HMG-CoA reductase.

Miyezo ya cholesterol ikugwa. Kuti athe kulipira kuchepa kwake, thupi limayamba kuthyola mamolekyulu omwe ali ndi LDL, zomwe zimapangitsa kutsika kwawo. Chinanso chowonjezera cha cholesterol ndi zotumphukira minofu. Ponyamula sterol, lipoprotein "zabwino" zapamwamba zimafunikira. Chifukwa chake, chiwerengero chawo chikukula.

Kuchepetsa kwathunthu cholesterol, LDL, triglycerides amachepetsa kupitilira kwa atherosulinosis. Popeza owonjezera mankhwala a metabolism wamafuta amatha kudziunjikira pamitsempha yamagazi. Pamene chiwonetserochi chikufunikira, chimakhala chokwanira kapena chokwanira chovalacho. Atherosulinosis yamitsempha yama mtima imayambitsa matenda a mtima, kugunda kwa ubongo, miyendo - mapangidwe a zilonda zam'mimba, phazi la necrosis.

Kuchita bwino kwa atorvastatin kumachepetsedwa kukhala zero ngati munthu satsata chakudya chotsitsa cholesterol. Thupi siligwiritsa ntchito zofunikira zake kubisa kuchepera kwa sterol, chifukwa limachokera ku chakudya.

Mankhwala a cholesterol amayamba kusintha pakapita masabata awiri kuchokera pomwe amayamba kumwa mapiritsi. Kuchuluka kwake kumatheka pambuyo pa masabata anayi.

Atorvastatin metabolites amathandizidwa mu bile, yomwe imapangidwa ndi chiwindi. Ndi kulephera kwa ziwalo, njirayi imakhala yovuta. Chifukwa chake, ndi matenda a chiwindi, mankhwalawa amayikidwa mosamala.

Liptonorm: Zizindikiro zogwiritsidwa ntchito

Malinga ndi malangizo ogwiritsira ntchito Liptonorm, mankhwalawa amalembedwa monga wowonjezera pakudya zamankhwala:

• hypercholesterolemia yoyamba,
• Hyperlipidemia
• heterozygous ndi homozygous banja hypercholesterolemia monga kuwonjezera pa mankhwala,

Kugwiritsa ntchito atorvastatin kumathandiza kuchepetsa chiopsezo cha matenda a mtima, matenda a mtima kwa odwala omwe ali ndi matenda a mtima. Kuphatikiza apo, odwala omwe amatenga Liptonorm nthawi zambiri samafuna kuti azingokhala, kukomoka, kugonekedwa kuchipatala ndi mavuto amtima.

Njira ya ntchito, Mlingo

Asanayambe chithandizo ndi Liptonorm, komanso nthawi yonseyi, wodwalayo ayenera kutsatira zakudya.

Mapiritsi amatengedwa kamodzi / tsiku, osatchula chakudya, koma nthawi zonse. Mlingo woyambira wabwino ndi 10 mg. Kuphatikiza apo, mulingo wake umasankhidwa payekha, poganizira momwe kusintha kwa cholesterol, LDL kumathandizira. Kusintha kwa Mlingo kumachitika osaposa nthawi 1 / masabata anayi. Mlingo woyenera wovomerezeka ndi 80 mg. Ndi mawonekedwe ofooka a thupi kumwa atorvastatin, wodwalayo amapatsidwa mankhwala amphamvu kwambiri kapena othandizira ndi mankhwala ena omwe amachepetsa cholesterol (othandizira a bile acids, cholesterol mayamwidwe).

Ndi kulephera kwa chiwindi, kuikidwa kwa Liptonorm kuyenera kutsagana ndi kuwunika momwe thupi limagwirira ntchito. Ngati achulukitsa monga momwe amagwiritsidwira ntchito, mankhwalawo amachotsedwa kapena mlingo wochepetsedwa ndi mankhwala.

Contraindication, mavuto

Liptonorm imaphatikizidwa mwa anthu omwe amamvera atorvastatin, lactose, gawo lililonse la mankhwala kapena analogue. Mapiritsi ali otsutsana mu:

• matenda a chiwindi
• kuchuluka kwa ALT, GGT, AST nthawi zopitilira 3,
• matenda oopsa
• matenda amatsenga
• ana ochepera zaka 18.

Liptonorm sinafotokozeredwe amayi oyembekezera, amayi oyamwitsa. Ngati kutenga pakati kukonzekera, mankhwalawo amayimitsidwa osachepera mwezi umodzi tsiku lino lisanachitike. Ngati muli ndi pakati mosakonzekera, muyenera kusiya kumwa mankhwalawo, kenako mukafunsani kwa dokotala. Adzifotokozeranso zoopsa zomwe zingachitike kwa mwana wosabadwayo, ndikuwuzani zomwe angachite.

Odwala ambiri amavomereza mosavuta mankhwalawa. Zotsatira zoyipa, ngati zilipo, zofatsa, zimazimiririka pakapita nthawi yochepa. Koma mwina kupitilira pang'ono kwa zochitika.

Malangizo a Liptonorm amachenjeza za zotsatirazi zoyipa:

• Thupi lamitsempha: nthawi zambiri kusowa tulo, chizungulire, kawirikawiri kupweteka mutu, kugona, kugona, kugona, kuchepa, kuwonjezeka, kupindika kwa mitsempha, kukwiya kwam'mutu, kulumikizana mwamphamvu, ziwalo zam'maso, kugona.
• Ziwalo zam'maso: Kuwona kawiri, kulira kwa khutu, maso owuma, ugonthi, glaucoma, kukoma kosokoneza.
• Matenda a mtima: kawirikawiri - kupweteka pachifuwa, kawirikawiri migraine, palpitations, hypotension kapena matenda oopsa, arrhythmia, angina pectoris, phlebitis.
• Machitidwe opatsirana: nthawi zambiri - bronchitis, rhinitis, kawirikawiri - chibayo, mphumu ya bronchial, nosebleeds.
• Matumbo a pakhungu: nseru, kutentha kwa mtima, kudzimbidwa kapena kutsekula m'mimba, kupweteka m'mimba, mpweya, kudya kapena kudya kwambiri, pakamwa pouma, kuyamwa, kumeza mavuto, kusanza, stomatitis, kutupa kwammimba, lilime, gastroenteritis, hepatitis, hepatic colic, zilonda zam'mimba. , kapamba, jaundice, chiwindi ntchito, magazi amitsempha, magazi m'kamwa.
• Musculoskeletal system: Nthawi zambiri - nyamakazi, kawirikawiri - minyewa yam'mimba, bursitis, kupweteka kwapakati, myositis, myopathy, myalgia, rhabdomyolysis, kuchuluka kwa minofu.
• Dongosolo la genitourinary: Nthawi zambiri - matenda amtundu, edema yodutsa, kawirikawiri - dysuria, kutupa kwa impso, ukazi, kutupa kwa ziwonetsero za mayeso, kutsika kwa libido, kusabala, kusokonezeka kwa msambo.
• Khungu: alopecia, thukuta lakuchuluka, chikanga, dandruff, kutuluka kwa malo.
• Thupi lawo siligwirizana: kuyabwa, zidzolo, kulumikizana ndi khungu, uritisaria, hypersensitivity reaction, photosensitivity, anaphylaxis.
• Zizindikiro zasayansi: shuga / otsika kwambiri, CPK yowonjezereka, phosphatase ya alkal, ALT, AST, GGT, kuchepa magazi, thrombocytopenia.
• Zina: kunenepa kwambiri, gynecomastia, kuchulukitsa kwa gout.

Nthawi zambiri, osuta, zidakwa, odwala matenda ashuga, chithokomiro, chiwindi matenda, hypotension amavutika ndi mavuto.

Kuyimitsidwa Liptonorm, komanso kulumikizana ndi dokotala ngati:

• kupweteka kapena kufooka kwakanthawi kwa minofu.
• kutentha kuwonjezeka
• kukokana.

Kuchita

Mankhwala atha kutsatira mankhwala otsatirawa:

• Maantacid (omeprazole, almagel),
• digoxin
• erythromycin, clarithromycin,
• proteinase zoletsa
• njira zakulera za pakamwa
• mafupa
• warfarin
• itraconazole, ketoconazole.

Mankhwalawa sagulitsidwa ndi mankhwala ku Russia. Wapitilira satifiketi yolembetsa. Mtengo wa Liptonorm panthawi yakusowa kwa kugulitsa anali ma ruble 284 pa phukusi la 10 mg, ma ruble 459 pa 20 mg.

Kuperewera kwa malo ogulitsa mankhwala a Liptonorm si vuto. Pali mitundu yambiri ya mankhwala omwe ali ndi zomwezi. Mutha kufunsa m'mafakisi:

• Atoris
• Anvistat
• Atomax
• Ator
• Tulip
• Atorvastitin-OBL,
• Atorvastatin-Teva,
• Atorvastatin MS,
• Atorvastatin Avexima,
• Atorvox
• Vazator
• Lipoford
• Liprimar
• Novostat,
• Torvas
• Torvalip
• Thorvacard
• Torvazin.

Kuphatikiza pamankhwala omwe ali pamwambapa, mutha kusankha omwe ali ndi liptonorm ndi kachitidwe kake:

• simvastatin - ma ruble a 144-346.,
• lovastatin - ma ruble 233-475.,
• rosuvastatin - 324-913 rub.,
• fluvastatin - 2100-3221 rub.

Ma statin onse ali ndi machitidwe ofanana, koma aliwonse ali ndi malingaliro ogwiritsira ntchito. Chifukwa chake, nthawi zonse muzifunsana ndi dokotala musanasinthe mankhwalawa.

Zinthu zomwe zidakonzedwa ndi olemba polojekitiyi
malingana ndi ndondomeko yakusinthaku.

Kutulutsa mawonekedwe ndi kapangidwe kake

Liptonorm likupezeka mu mawonekedwe a mapiritsi: atakulungidwa ndi chipolopolo choyera, chozungulira, biconvex, kumapeto - koyera kapena pafupifupi (ma PC 14. M'matumba, matuza awiri mu mtolo wa makatoni).

Mphamvu yogwira ya mankhwala ndi atorvastatin (mu mawonekedwe a calcium calcium). Piritsi limodzi lili 10 kapena 20 mg.

Omwe amathandizira: crosscarmelose, hydroxypropyl cellulose, magnesium stearate, pakati pa 80, lactose, hydroxypropyl methyl cellulose, microcrystalline cellulose, titanium dioxide, calcium carbonate, polyethylene glycol.

Mawonekedwe ndi kipimo

Chofunikira chachikulu cha Liptonorm ndi calcium ya calcium ya Atorvastatin. Mwa zina zake zothandiza ndi monga:

• calcium carbonate
• Zaka 80,
• MCC
• zakudya zowonjezera E463 ndi E572,
• sodium croscarmellose,
• lactose
• madzi oyeretsedwa.

Liptonorm amapangidwa piritsi. Mapiritsi ophatikizidwa a 10 mg kapena 20 mg amapezeka mu kuchuluka kwa 7, 10, 14, 20, 28 kapena 30 ma PC.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amalembera kuwonjezera cholesterol. Mchitidwe wake umalimbana ndikulepheretsa zomwe zili zam'magazi m'magazi. Liptonorm iyenera kugwiritsidwa ntchito muyezo womwe dokotala watchulidwa.

Mankhwala a Liptonorm ali ndi zochitika zosiyanasiyana. Mankhwala ali ndi lipid-kutsitsa ndi anti-atherosulinotic kwenikweni. Mphamvu ya lipid yotsitsa lipidorm ndikuti mphamvu yake yogwira imathandizira cholesterol ndikuchotsa tinthu ta LDL m'madzi a m'magazi.

Mphamvu yotsutsa-atherosulinotic imakhazikika chifukwa chakuti mankhwalawa amatha kupondereza kukula kwa maselo m'mitsempha yamagazi ndikuchepetsa zomwe zili ndi zigawo zamagazi lipid. Chifukwa cha zochita zambiri, mankhwalawa ayenera kuyikidwa pa matenda otsatirawa:

• kutengera kwa chibadwa cha zomwe zili ndi lipid mopambanitsa,
• dyslipidemia,
• hetero - kapena homozygous mawonekedwe am'banja mtundu hypercholesterolemia.

Liptonorm sayenera kusokonezedwa ndi mankhwala ochepetsa Liponorm. Kuphatikiza apo chomaliza ndichakudya chowonjezera, chimangogulitsidwa m'mapiritsi.

Zotsatira zoyipa

Ngati wodwalayo anyalanyaza mwadala kapena akuchulukitsa kuchuluka kwa mapiritsi, akhoza kukhudzidwa ndi chiopsezo cha mavuto. Kusagwirizana ndi malamulo a zamankhwala zingayambitse kugonja kutsatira machitidwe ndi ziwalo:

1. CNS Zowonetsera zazikulu za kusayenda bwino kwamanjenje ndi chizungulire komanso kusokonezeka kwa tulo. Nthawi zina, odwala amakumana ndi zovuta monga maliseche, asthenia, ataxia, paresis ndi hyperesthesia, zomwe zimayambitsa kukhumudwa kwa nthawi yayitali.
2. Zosangalatsa. Zizindikiro zakuphwanya magwiridwe antchito awo amawonedwa kuti ndi kutupa m'maso, kuchepa kwa chinyezi, kusowa kwazinthu zilizonse mukamadya, kutaya mphamvu yodziwira fungo.
3. Dongosolo la genitourinary. Matenda a urological ndi ukazi, vuto la kukodza, kukula kwa impso kulephera pa mankhwala, kuchepa kwa potency ndizovuta zina zomwe zimachitika panthawi ya mankhwala a Liptonorm.
4. Dongosolo la Lymphatic. Njira yachipatala yochiritsira imatha kupangitsa kukhazikika kwa matenda a magazi - lymphadenopathy, kuchepa magazi kapena thrombocytopenia.
5. Tizilombo timimba. Kusagwirizana ndi malamulo a mapiritsi malinga ndi malangizo kumayambitsa kukula kwa matenda am'mimba ndi chiwindi, zomwe zimawonetsedwa ndi kutulutsa, ndikung'ung'uza, kusanza Reflex, hepatic colic, komanso hepatitis.
6. Mtima wamtima. Odwala amatha kudwala matenda oopsa, angina pectoris, chifuwa.
7. Dongosolo lenileni. Kuchita kwa zotupa kapena zovuta zamkati zimaphatikizapo zotupa, kuyabwa, seborrhea, chikanga, kawirikawiri urticaria kapena anaphylactic.

Malangizo ogwiritsira ntchito

Liptonorm ndi woimira gulu la mankhwala omwe amagwiritsidwa ntchito pochiza milingo yambiri ya lipid. Atorvastatin - gawo logwira ntchito, lili ndi mphamvu ya kutsitsa kwa lipid, ndiye kuti, amathandiza kuchepetsa zam'mapapo zam'magazi. Zomwe zili m'magazi zimakwera pambuyo pa ola limodzi pambuyo pochita. M'mawa, chiwerengerochi chili pafupifupi 30% kuposa madzulo.

Zotsatira zakugwiritsa ntchito ma statins zimawonedwa patatha masiku 14. Kuchuluka kwakukulu kumatheka pokhapokha mwezi umodzi wogwiritsidwa ntchito.

Kumwa mankhwalawa sikudalira kudya chakudya mthupi. Mkhalidwe wokhawo womwe umathandizira kuti mankhwalawa agwiritsidwe ntchito ndi kuchuluka kwa mapiritsi tsiku lililonse. Wodwala sayenera kupitilira muyeso - 10 mg patsiku. Kuchulukitsa mlingo wa tsiku ndi tsiku kumatha kubweretsa vuto lalikulu kwa thanzi komanso kumayambitsa zovuta zina.

Asanayambe chithandizo, madokotala amayenera kuwunika ntchito ya chiwindi. Akatswiri amalimbikitsa kusamala ndikuyendera dokotala pafupipafupi kuti ayang'anire ntchito ya chiwindi kwa miyezi itatu yoyambirira mukangoyamba chithandizo. Kusintha kwa Mlingo wambiri kumatha kuchitika milungu ingapo mutayamba chithandizo, koma osati kangapo nthawi imodzi pamwezi. Pakulandila kwake, madokotala ayenera miyezi isanu ndi umodzi iliyonse. kusintha kusintha kwa enzyme bwino.

Malinga ndi momwe agwiritsidwire ntchito, mapiritsi amayenera kusungidwa pamalo abwino. Zizindikiro zovomerezeka m'chipinda chino +25 madigiri.

Gwiritsani ntchito pa nthawi yoyembekezera

Zomwe zimagwiritsidwa ntchito ndi mankhwalawa ndizoletsedwa kwa odwala panthawi yoyembekezera komanso nthawi yoyamwitsa (yoyamwitsa) chifukwa cha zotsatira zoyipa za thupi la mwana wakhanda. Ngati wodwala akukonzekera kutenga pakati, ndibwino kumusiya kwa miyezi ingapo. Amayi pa nthawi ya mankhwalawa ndi Liptonorm sayenera kunyalanyaza kulera.

Zovuta zina zimaphatikizapo ubwana ndi unyamata. Zambiri pokhudzana ndi chithandizo cha ana ndi mankhwala mpaka pano sizikupezeka.

Mtengo wa mankhwala

Mtengo wa mankhwala Liptonorm umatsimikiziridwa ndi njira zingapo - kuchuluka kwa matuza mu phukusi, mlingo, ndi zina. Pafupifupi, mapiritsi 10 mg angagulidwe ku mankhwala a 200-250 rubles. Mtengo wa paketi 28 ma PC. 20 mg iliyonse ndi ma ruble 400-500.

Ku Ukraine, mtengo wamankhwala pamtengo wa 20 mg ndi 250-400 UAH.

Analogs Liptonorm

Ngakhale kuti Liptonorm ndi mankhwala othandiza kwambiri, siabwino kwa odwala onse. Hypersensitivity kwa gawo lina la mankhwalawa ndikupangidwadi ndi zifukwa ziwiri zazikulu zosinthira ndi analogue yotsika mtengo.

Mankhwala otsatirawa ndi amodzi mwa fanizo la Liptonorm:

Kugwiritsa Ntchito

Ndemanga ya momwe amagwiritsidwira ntchito akuwonetsa kuti madokotala nthawi zambiri amamulembera wodwalayo popanda kuwafotokozera mwatsatanetsatane za mawonekedwe ake ndi njira zake zoyipa.

Tamara, Moscow: "M'masiku oyamba kumwa mapiritsi, ndinayamba kumva kupweteka m'mimba mwanga, ndikung'ung'udza m'mimba mwanga, ndipo masiku angapo pambuyo pake - nseru ndi kusanza. Sindinaphatikizepo mwanjira iliyonse mawonetsedwe awa ndi kutenga Liptonorm. Popeza ndakhala ndikuvutika ndi matenda am'mimba kuyambira ndili mwana ndikusintha pang'ono pazakudya zanga, nthawi yomweyo ndidatembenukira kwa dokotala wa gastroenterologist. Chifukwa cha adotolo, ndazindikira zomwe zidayambitsa kusokonezeka m'mimba, komabe ndimasamala za funsoli. Chifukwa chiyani wondyang'anira zakudya samandiwchenjeza za zotsatira zake? "

Katherine, Novosibirsk: “Kulemera kwambiri kwandipitilira kuyambira ndili mwana, koma nditakwanitsa zaka 30 ndinasankha kudzisamalira ndikudziwa chomwe chayambitsa vuto langali. Kafukufuku wa Laborator awonetsa kuti choyambitsa ndi cholesterol yayikulu ndipo wondyambitsa zakudya adandipatsa Liptonorm kwa ine.Patsiku loyamba, kuthamanga kwa magazi kwanga kudakwera kufika pa 150. Tsiku lotsatira m'mawa kupanikizika kunali kwachilendo, koma pambuyo pa nkhomaliro adalumphanso mpaka 160. Pambuyo pake ndidaganiza zowerenga malangizowo ndipo pomaliza ndidamvetsetsa zomwe zimachitika. Kuthamanga kwa magazi ndi zotsatira zamankhwala. Kupanikizika kunasiya masiku 5 atangoyamba kumene chithandizo chamankhwala. ”

Kuwunikira ndemanga zonse pamwambapa pa kugwiritsa ntchito mapiritsi a Liptonorm, akuyenera kudziwa kuti ndikofunikira kukaonana ndi dokotala musanagwiritse ntchito. Choyamba, zimachitika chifukwa chakuti mankhwalawo ndi a gulu la ma statins omwe angalimbane ndi kuchuluka kwa mafuta m'thupi. Monga mukudziwira, kuikidwa kapena kuthetsedwa kwa wothandizira aliyense wa mahomoni kumatha kuchitika ndi katswiri.

Kachiwiri, mankhwalawa ali ndi zotsutsana zosiyanasiyana komanso zoyipa kuchokera m'matumbo am'mimba, chapakati chamanjenje, mtima ndi zina zofunika. Katswiriyu akuyenera kupereka mankhwala, afotokozere zomwe zikuchitika, ndikuwuzanso wodwalayo za zovuta zomwe zingachitike.

Mlingo ndi makonzedwe

Asanayambe kulemba Liptonorm komanso nthawi yonse yogwiritsira ntchito, wodwala ayenera kutsatira zakudya zomwe zimapatsa kuchepa kwa magazi.

Mankhwalawa amatengedwa pakamwa kamodzi pa tsiku, mosasamala zakudya, nthawi yomweyo.

Mlingo woyamba wa tsiku ndi tsiku umakhala 10 mg. Kenako, mlingo umasinthidwa payekhapayekha, kutengera cholesterol yokhala ndi lipoproteins yotsika. Zotheka pakati pa kusintha kwa kumwa sikuyenera kupitirira masabata anayi. Mulingo wovomerezeka tsiku lililonse ndi 80 mg.

Zotsatira zoyipa

Zotsatira zoyipa za mankhwalawa (nthawi zambiri - zopitilira 2%, kawirikawiri - zosakwana 2%):

• Pakati mantha dongosolo: Nthawi zambiri - chizungulire, kusowa tulo, kawirikawiri - malaise, asthenic syndrome, kugona, mutu, zovuta, zotupa, zotupa zam'mitsempha, ataxia, paresthesia, kupuwala nkhope, kupsyinjika, kugona
• Mtima dongosolo: Nthawi zambiri kupweteka pachifuwa, kawirikawiri postural hypotension, arrhythmia, vasodilation, kuchuluka kwa mtima, angina pectoris, kuchuluka kwa magazi, phlebitis,
• Zida zam'maso: conjunctiva, glaucoma, kutuluka kwa m'maso, amblyopia, chisokonezo chogona, parosmia, kulira m'makutu, ugonthi, kupotoza kwa kukoma, kuwonongeka.
• Njira yothandizira kupumira: kawirikawiri - matenda a brinchitis, bronchitis, osowa - mphuno, chibayo, mphumu, bryschi,
• Matumbo: Nthawi zambiri - cheilitis, magazi m`kamwa, zotupa ndi zotupa zakumwa zam'mimba, phokoso, matenda owuma, mkamwa, kudzimbidwa, kupweteka m'mimba, kusefukira, mseru, matumbo, kupweteka m'mimba, kupweteka kwam'mimba, kusanza, dysphagia , esophagitis, anorexia kapena kuchuluka kwa chilonda, duodenal zilonda, chiwindi, gastroenteritis, chiwindi, mkhutu chiwindi ntchito, cholestatic jaizi, kapamba, melena, magazi amitsempha,
• Genitourinary dongosolo: Nthawi zambiri - zotumphukira edema, matenda a urogenital, kawirikawiri - hematuria, nephritis, nephrourolithiasis, dysuria (kuphatikiza kwamkodzo kapena kusungika kwamkodzo, nocturia, pollakiuria, kuvomerezera kwamikodzo), metrorrhagia, kutaya magazi mu maliseche, epididymitis, umuna, kuchepa kwa libido, kusabala,
• Matenda a minofu ndi mafupa: Nthawi zambiri - nyamakazi, kawirikawiri - tendosynovitis, bursitis, myositis, myalgia, arthralgia, torticollis, kukokana kwa miyendo, mgwirizano wapakati, minofu hypertonicity, myopathy, rhabdomyolysis,
• Hematopoietic dongosolo: lymphadenopathy, anemia, thrombocytopenia,
• Dermatological ndi thupi lawo siligwirizana: kawirikawiri - kuchuluka thukuta, seborrhea, xeroderma, eczema, petechiae, ecchymosis, alopecia, kuyabwa, zotupa khungu, kukhudzana ndi dermatitis, kawirikawiri - nkhope edema, angioedema, urticaria, photosensitivity, multiforme osachita poyipa wa mafupa. Matenda a Stevens-Johnson, anaphylaxis,
• Zowonetsa zasayansi: kawirikawiri - albinuria, hypoglycemia, hyperglycemia, kuchuluka kwa zamchere phosphatase, serum creatinine phosphokinase ndi hepatic transaminases,
• Zina: kawirikawiri - mastodynia, gynecomastia, kulemera kwakukulu, kuchuluka kwa gout.

Malangizo apadera

Munthawi yonse ya chithandizo, kuyang'anira mosamala ma chidziwitso chazachipatala ndi ma labotale ndizofunikira. Ngati masinthidwe ofunika a pathological apezeka, mlingo wa Liptonorm uyenera kuchepetsedwa kapena kudya kwake kuthe.

Musanapereke mankhwala, pakadutsa milungu 6 ndi 12 atangoyamba kumene chithandizo, mutatha kuchuluka kwa mankhwalawa, komanso nthawi zonse munthawi ya chithandizo (mwachitsanzo, miyezi isanu ndi umodzi iliyonse), ntchito ya chiwindi iyenera kuyang'aniridwa. Kusintha kwa ntchito ya enzyme nthawi zambiri kumawonedwa m'miyezi itatu yoyamba kumwa Liptonorm. Pankhani ya kuchuluka kwa ntchito ya hepatic transaminases, odwala ayenera kuyang'aniridwa ndi achipatala mpaka zizindikiro zibwezeretsedwe. Ngati phindu la alanine aminotransferase (ALT) kapena aspartate aminotransferase (AST) limaposa katatu kuposa mtengo womwewo wa congenital adrenal hyperplasia, tikulimbikitsidwa kuti muchepetse mlingo kapena muimeni mankhwalawo.

Ndikofunikira kuyerekeza phindu lomwe likuyembekezeka komanso kuchuluka kwa chiwopsezo ngati kuli kofunikira kuperekera Liptonorm kwa wodwala yemwe amalandila cyclosporine, erythromycin, clarithromycin, immunosuppressants, fibroic acid exivatives, nicotinic acid (mu Mlingo wokhala ndi lipid-kuchepetsa zotsatira), ma antifungal agents omwe ndi azole derivatives. Ngati pali zizindikiro za kupweteka kwa minofu, kufooka, kapena ulesi, makamaka miyezi ingapo yoyambirira yamankhwala kapena kuwonjezeka kwa mlingo uliwonse wa mankhwalawa, mkhalidwe wa wodwalayo uyenera kuyang'aniridwa mosamala.

Ngati pali zovuta zomwe zingachitike chifukwa cha kukanika kwa impso chifukwa cha matenda a rhabdomyolysis (mwachitsanzo, kuchepa kwa ziwopsezo, kuchepa kwamphamvu kwa metabolic ndi endocrine, matenda opweteka kwambiri, kuvulala kwambiri, opaleshoni yayikulu, kusalinganika kwa electrolyte), komanso ngati pali vuto lalikulu lomwe lingasonyeze kukula kwa myopathy, Liptonorm iyenera kuthetsedwa kwakanthawi kapena kuthetseratu.

Wodwalayo ayenera kuchenjezedwa za kufunika kofunsa dokotala ngati mukumva kupweteka kapena kufooka kwa minofu yosadziwika, makamaka ngati akuphatikizidwa ndi malaise ndi / kapena malungo.

Panalibe malipoti oyipa a Liptonorm pa kuyendetsa magalimoto ndi kugwira ntchito yofunika chidwi.

Kuyanjana kwa mankhwala osokoneza bongo

Immunosuppressants, antifungal agents omwe amachokera ku azole, fibrate, cyclosporine, erythromycin, clarithromycin, nicotinamide amawonjezera kuchuluka kwa atorvastatin m'madzi a m'magazi komanso chiopsezo chokhala ndi myopathy.

Mlingo wazomwe zimagwira ntchito za Liptonorm umakulitsidwa ndi CYP3A4 inhibitors.

Maantacidanti amachepetsa kuchuluka kwa atorvastatin ndi 35%, koma osakhudza cholesterol yomwe ili ndi otsika osalimba lipoproteins.

Mukamamwa liptonorm tsiku lililonse 80 mg munthawi yomweyo ndi digoxin, kuchuluka kwa otsiriza m'magazi kumawonjezeka ndi 20%.

Liptonorm, imatengedwa tsiku lililonse 80 mg, imachulukitsa kuchuluka kwa njira zakulera zam'mlomo zomwe zimakhala ndi ethinyl estradiol kapena norethidrone ndi 20%.

Mphamvu ya kuphatikizika kwa atorvastatin ndi colestipol imaposa zovuta zomwe zimachitika mu mankhwala aliwonse payekhapayekha.

Panthawi yomweyo kugwiritsa ntchito warfarin m'masiku oyamba ochizira, nthawi ya prothrombin imayamba kuchepa, koma patatha masiku 15 chizindikiro, monga lamulo, chimakhazikika. Pazifukwa izi, odwala omwe amalandila zofanana ayenera kuwongolera nthawi ya prothrombin nthawi zambiri kuposa masiku onse.

Pa chithandizo, sikulimbikitsidwa kudya madzi a mphesa, chifukwa amatha kuthandizira kuchuluka kwa atorvastatin m'madzi a m'magazi.