AMIX vet HTTs (AMIX vet STS)

Zizindikiro zogwiritsidwa ntchito:

Type II shuga mellitus, momwe shuga yamagazi sangathe kuthandizidwa mokwanira ndi kuwonda, kudya, komanso kuchita masewera olimbitsa thupi.

Mlingo wa mankhwalawa umatsimikiziridwa molingana ndi zotsatira za kuyesa kwa magazi ndi mkodzo kwa shuga. Mlingo woyambirira wa mankhwalawa ndi 1 mg ya glimepiride 1 nthawi patsiku. Mukawunika momwe wodwalayo aliri, mankhwalawa amagwiritsidwa ntchito ngati chithandizo chothandizira. Ngati kuwongolera kwakuthupi kwa wodwalayo sikungatheke, muyeso uyenera kuchulukitsidwa mosamala (potengera zotsatira za kuwongolera glycemic) mpaka 2 mg, 3 mg kapena 4 mg ya glimepiride tsiku lililonse masabata 1 mpaka 2.

Kumwa mlingo wa glimepiride wopitilira 4 mg patsiku umawongolera pokhapokha, ndipo umayikidwa palokha. Mulingo woyenera kwambiri ndi 6 mg wa glimepiride patsiku.

Odwala omwe kugwiritsa ntchito Mlingo wa metformin wokwanira tsiku lililonse sanapeze chindapusa chokwanira cha kupatsa mphamvu kwa metabolism, njira yokhazikika yokhala ndi glimepiride ingayambike. Mlingo wa metformin uyenera kusiyidwa chimodzimodzi, ndipo chithandizo chokhala ndi glimepiride chiyenera kuyambitsidwa ndi milingo yotsika, yomwe iyenera kuwonjezeka pang'onopang'ono mpaka mlingo wambiri watsiku ndi tsiku, kutengera mulingo woyenera wa metabolic. Chithandizo chophatikiza chotere chiyenera kuyambitsidwa moyang'aniridwa ndi dokotala.

Odwala omwe chakudya cha metabolism cha carbohydrate sichinalipiridwe ngakhale mutamwa mlingo waukulu wa tsiku ndi tsiku, ngati mwadzidzidzi, mutha kuyamba chithandizo chokwanira ndi insulin. Odwala otere ayenera kupitiliza kutenga mlingo wapitawu wa glimepiride ndipo nthawi yomweyo ayambe kugwiritsa ntchito Mlingo wa insulin, womwe pang'onopang'ono umawonjezeka, motero, digiri ya metabolism. Chithandizo chophatikiza chotere chiyenera kuyambitsidwa moyang'aniridwa ndi dokotala.

Bongo

• Kukula pakati pa zolimbitsa thupi ndi chakudya chamafuta,
• Kusintha kwachiwiri kapena (makamaka ukalamba) kusakwanira kwa wodwalayo kukaonana ndi dokotala,
• Kuchepa kwa impso
• Kumwa mowa, makamaka kuphatikiza ndi kudya zakudya.
• Kukanika kwa chiwindi,
• Kusintha kwazomwe zimachitika mu endocrine system yomwe imakhudza kagayidwe kazakudya (mwachitsanzo, adenohypophysial kapena adrenocortical insuffence, chithokomiro cha chithokomiro),
• Kugwiritsa ntchito munthawi yomweyo mankhwala ena (onani gawo "Kuyanjana ndi mankhwala ena ndi mitundu ina yoyanjana").

Ngati zinthu zomwe zili pamwambapa ndi zochitika za hypoglycemia zilipo, muyenera kudziwitsa dokotala wanu, chifukwa panthawiyi kuyenera kuyang'anira odwala kumafunika. Zinthu zomwe zimawonjezera chiopsezo cha hypoglycemia zimafunikira kusintha kwa Amiksu kapena njira yonse ya mankhwala. Mlingo uyenera kusinthidwa ngati moyo wa wodwalayo wasintha kapena nthenda yomwe imayenderana. Zizindikiro za hypoglycemia, zomwe zikuwonetsa kuwukira kwa adrenergic, zitha kusungunuka kapena kusowa kwathunthu muzochitika pamene hypoglycemia imayamba pang'onopang'ono mwa odwala omwe ali ndi vuto la neuronomic, odwala okalamba. Zizindikiro zimathanso kutsitsidwa mwa odwala omwe amathandizidwa nthawi yomweyo ndi b-adrenergic blockers omwe ali ndi reserpine, clonidine, guanethidine, kapena njira zina. Hypoglycemia, pafupifupi pazochitika zonse, imatha kuimitsidwa msanga chifukwa cha kudya kwakanthawi zamagulu, monga shuga kapena glucose (mwachitsanzo, mu mawonekedwe a chidutswa cha shuga chotsekemera ndi msuzi wa zipatso kapena tiyi). Chifukwa chake, wodwalayo nthawi zonse azikhala ndi glucose osachepera 20. Zokomera zotsekemera sizothandiza pochiritsa hypoglycemia. Kuchokera pazomwe mukugwiritsa ntchito mankhwala ena a sulfanylurea, zimadziwika kuti, ngakhale atapambana poyambirira njira zomwe amachitazo, zotheka kuchepa kwa hypoglycemia ndizotheka. Kusamala mosamala ndi mosalekeza kwa mkhalidwe wa wodwalayo ndikofunikira. Hypoglycemia yayikulu imafunikira chithandizo choyang'aniridwa ndi adokotala, ndipo nthawi zambiri, kugonekedwa kwa odwala kuchipatala.

Zotsatira zoyipa:

Zizindikiro za hypoglycemia: nseru, chizungulire, kupweteka mutu, kusanza, kusokonezeka kwa kugona, "mimbulu", kudya, kusowa tulo, kusokonezeka kwa chidwi, masomphenya, kukomoka kwapakati, kuchepa tulo, nkhawa, chisokonezo, kuyankhula, kukwiya komanso kukhumudwa. Kuphatikiza apo, kusintha kwa adrenergic kumatha kuchitika: tachycardia, ochepa matenda oopsa, palpitations, thukuta, nkhawa, mtima arrhythmias ndi angina kuukira. Aphasia, kunjenjemera, paresis, kusokonezeka kwa chidwi, kusowa pogwira, kulephera kudziletsa, kugona, kugona komanso kukhumudwa mpaka kugona, kupuma kosafunikira komanso bradycardia kumatha kuchitika.

Chithunzi cha chipatala cha matenda a hypoglycemia chitha kufanana ndi sitiroko. Pambuyo pogwirizanitsa mkhalidwe wa glycemic, zizindikiro zonsezi nthawi zambiri zimatha.

• Zokhudza zomverera: munthawi ya chithandizo (makamaka magawo oyamba), kuwonongeka kwakanthawi kochepa kumatha kuchitika, chifukwa cha kusintha kwa shuga m'magazi.
• Matumbo am'mimba: kutulutsa kwam'mimba, monga kupweteka kwam'mimba komanso kutsegula m'mimba, kusanza, nseru, kumva kukakamiza kapena kusefukira kwa epigastrium, nthawi zina pamakhala kuchuluka kwa ntchito ya enzyme ya chiwindi komanso kukanika kwa chiwindi (jaundice ndi cholestasis), hepatitis, yomwe ingayambitse kulephera kwa chiwindi.
• Njira yozungulira: Kusokonezeka kwakukulu kumatha kuchitika. Nthawi zina, thrombocytopenia ndipo, mwapadera, granulocytopenia, hemolytic anemia, leukopenia, erythrocytopenia, agranulocytosis ndi pancytopenia (chifukwa cha myelosuppression).
• Zotsatira zina zoyipa Thupi lawo siligwirizana kapena pseudo-matupi awo sagwirizana ndi uritisaria, kukhuthala kapena kuyabwa nthawi zina kumachitika. Ngati ming'oma itachitika, pitani kuchipatala mwachangu.

Izi, monga lamulo, ndizabwino, koma zimatha kupita patsogolo, limodzi ndi dyspnea ndi kuchepa kwa magazi mpaka kugwedezeka. Nthawi zina, pamatha kudziwa khungu pakapangidwe ka kuwala, matupi awo a vasculitis ndi kutsika kwa mulingo wa sodium mu seramu yamagazi.

Mogwirizana ndi mankhwala ena ndi mowa:

Kugwiritsa ntchito mankhwala Amix ndi mankhwala ena kukonzekera kungayambitse kuwonjezeka kosafunikira kapena kufooketsa mphamvu ya hypoglycemic ya yogwira ntchito. Mankhwala ena amayenera kumwedwa pokhapokha ngati mwakumana ndi dokotala (kapena monga mwawongolera) dokotala.

Izi ziyenera kuganiziridwa mukamatenga glimepiride ndi CYP2C9 inhibitors (mwachitsanzo fluconazole) kapena CYP2C9 inducers (mwachitsanzo rifampicin).

Zochitika zamankhwala zokhala ndi glimepiride kapena zotumphukira zina za sulfonylurea zimawonetsa kuthekera kwa mitundu iyi: Kuthana ndi zomwe zimapangitsa kuchepetsa magazi. Nthawi zina, izi zimabweretsa ku hypoglycemia ndikumwa imodzi ya mankhwalawa: phenylbutazone, azapropazone ndi oxyphenbutazone, insulin ndi mankhwala opatsirana pakamwa, metformin, salicylates a tara-amino salicylic acid, anabolic steroids ndi mahomoni achimuna a amuna, chloramphenicolinum, antifumorofeninololinin fibrate, ACE zoletsa, fluoxetine, allopurinol, sympatholytics, cyclo-, tri-taifosfamidiv, sulfinpyrazone.

Kuchepetsa mphamvu ya mankhwalawa (kuchepa kwa mphamvu yochepetsera kuchuluka kwa shuga wamagazi) kapena kuwonjezeka kwa glucose amachititsa chifukwa cha munthawi yomweyo makonzedwe a Amix ndi mankhwala otsatirawa: estrogen ndi progestogen, mankhwala a saluretics ndi thiazide diuretics, mankhwala opatsa mphamvu a glucocorticoids, phenothiazine, chlorpromazine. , nicotinic acid (mu milingo yayikulu) ndi zotumphukira za asidi a nicotinic, mankhwala ofewetsa thukuta (ntchito yayitali), phenytoin, diazoxide, glucagon, barbiturates, rifampicin, aceto amide.

Kugwiritsa ntchito munthawi yomweyo motsutsana ndi H2-receptors, b-blockers, clonidine ndi reserpine kumatha kuyambitsa mphamvu kapena kufooketsa kuchepa kwa shuga wamagazi omwe amayamba chifukwa cha kutenga Amiksu. Ma Sympatolytics monga b-blockers, clonidine, gaunetidine ndi reserpine amatha kuphimba kapena kuthetsa zizindikiro za vuto la adrenergic, zomwe zimatsogolera ku hypoglycemia. Mowa wogwiritsidwa ntchito mosiyanasiyana ungakulitse kapena kufooketsa mphamvu ya gloglycemic ya glimepiride m'njira yosadalirika. Glimepiride ikhoza kukulitsa kapena kufooketsa mphamvu yokhudzana ndi zotsatira za coumarin.

Zopangidwa ndi katundu:

Zopangidwa: Piritsi 1 ili ndi glimepiride 1.2, 3 kapena 4 mg.

Kutulutsa Fomu: Mapiritsi 1 mg No. 10x3, No. 10x9, No. 10x12.

Glimepiride ndi mankhwala omwe amagwiritsidwa ntchito potsatira mankhwala, sulfonylurea. Amagwiritsidwa ntchito pakamwa, ali ndi vuto la hypoglycemic. Imalimbikitsa kupanga insulin ndi ma cell a beta a kapamba, imawonjezera chidwi cha zotumphukira kuti insulini, ichulukitse insulini. Pambuyo pakulamula pakamwa, mayamwidwe a glimepiride ndi 100%. Kudya sikumakhudza bioavailability, koma kumangochepetsa pang'ono mayamwidwe. Cmax (kuchuluka kwa ndende ya magazi mu seramu) imafikiridwa patatha maola 2,5 pambuyo pakukonzekera kwamlomo (avareji mu seramu yamagazi ndi 0.3 μg / ml pamene mukumwa Mlingo wambiri wa 4 mg tsiku). Pali ubale womwe ulipo pakati pa mlingo ndi Cmax, komanso pakati pa mlingo ndi AUC (dera lomwe lili pansi pa nthawi yopondera).

Kugawidwa kwa glimepiride kumadziwika ndi gawo lotsika kwambiri (pafupifupi malita 8.8), omwe ali ofanana ndi kuchuluka kwa magawidwe a albumin, chilolezo chotsika (pafupifupi 48 ml / min.), Mapulogalamu ambiri omanga mapuloteni a plasma (> 99%). Biotransfform ndi kuchotsedwa: pafupifupi plasma theka moyo wa glimepiride ndi maola 5 mpaka 8. Ubwinowu ndi wofunikira kuti uzindikire serum glimepiride moyikirapo pambuyo pamiyeso yambiri. Pambuyo pa kumwa Mlingo waukulu, kuwonjezeka pang'ono kwa theka la plasma kwa glimepiride kunadziwika.

Malo osungira: Sungani ku kutentha mpaka 30 ° C. Sungani kutali ndi ana.

Kutulutsa Fomu

• Konzani 1: mapiritsi a oval pinki okhala ndi mzere wogawa mbali zonse ziwiri.
• Amix 2: mapiritsi obiriwira obiriwira okhala ndi mzere wogawika mbali zonse ziwiri.
• Amix 3: mapiritsi achikasu achikasu ndi mzere wogawika mbali zonse ziwiri.
• Amix 4: mapiritsi amtambo obiriwira okhala ndi mzere wogawika mbali zonse ziwiri.

Mapiritsi 10 mu chithuza - matuza atatu, asanu ndi anayi kapena khumi ndi awiri m'bokosi la katoni.

Pharmacodynamics ndi pharmacokinetics

Mankhwala

Glimepiride Ndiye hypoglycemic wothandizira pakamwa pakamwa (zochokera sulfonylureas) Imayendetsa kusankha insulin maselo a pancreatic B, amathandizira kumasulidwa insulinzimawonjezera kukhudzika kwa minofu ku mamolekyulu insulin.

Pharmacokinetics

Pambuyo kutenga bioavailability glimepiridekuyandikira 100%. Chakudya sichimakhudza kuchuluka kwa mayamwa, koma chimalepheretsa pang'ono. Kuzindikira kwakukulu magazi (khazikitsani maola 2-3 mutayamba kumeza.)

Mlingo womangiriza mapuloteni a plasma woposa 99%. Hafu ya moyo ndi maola 6-8. Kupanga kotheratu. Amayikamo mkodzo komanso m'matumbo.

Contraindication

Matenda a shugachoyambirira matenda ashuga, matenda ashuga ketoacidosis, mimba kapena nyere. Komanso, mankhwalawa sangathenso kuvomerezeka kwa odwala omwe ali ndi chidwi ku zigawo za mankhwala, zotumphukira sulfonylureas kapena kwa ena mankhwala a sulfa.

Zotsatira zoyipa

Kukula kwa zizindikiro zotsatirazi hypoglycemia: "Wolf" kulakalakanseru mphwayikusanza kugona, mutu, nkhawa, kukwiya,chisokonezo cha kugona, kusokonezeka kwa nkhawa, kuchepa kwa machitidwe, chisokonezo, kukhumudwakusokonekera kwa mawu, kuwonongeka kwa mawonekedwe, aphasia, kugwedezakuphwanya zamanyazi, paresischizungulire delirium, kukokana kwapakatikulephera kudziwa bradycardia. Zothekanso adrenergiczimachitika: nkhawa thukuta, ochepa matenda oopsakulanda angina pectoris, tachycardia, arrhythmia.

Mwa cha mawonedwe: kuwonongeka kwakanthawi.

Mwa chimbudzi: kupweteka kwam'mimba, mseru, kusanza, kumva kukhathamira kwa epigastrium, kutsegula m'mimbakusintha kwamankhwala a chiwindi michere, chiwindi.

Mwa hematopoiesis: leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, granulocytopenia, erythrocytopenia, pancytopenia.

Zotsatira zina zoyipa: kuyabwa, urticaria, dyspneakuchepetsedwa kwa mavuto.

Nthawi zina, zotsatirazi zingathenso kuonedwa: photosensitization, Matupi a vasculitiskuchepetsa magazi sodium m'magazi.

Malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Zomwe zimayambira bwino pakudya: kudya, kuchita zolimbitsa thupi pafupipafupi komanso kuyang'anira magazi ndi mkodzo nthawi zonse. Mlingo wa mankhwalawa umatsimikiziridwa ndi zotsatira za kusanthula.

Mlingo woyambirira ndi 1 mg glimepiride tsiku ndi tsiku. Mlingo womwewo umagwiritsidwa ntchito ngati chithandizo chothandizira mukakwaniritsa kuyang'anira mkhalidwe wa wodwalayo.

Ngati kulakalaka kofunikira pa vuto la wodwala sikungatheke, mlingo umachulukitsidwa ndi 1, 3 kapena 2 mg glimepiridepatsiku lililonse mpaka milungu iwiri.

Phwandoglimepiride zopitilira 4 mg patsiku zimachitika pokhapokha pokhapokha. Mulingo waukulu mpaka 6 mg ya mankhwalawa patsiku.

Odwala popanda chindapusa cha kuphatikiza kagayidwe kazakudya, ngakhale mutadya kwambiri Mlingo, chithandizo chitha kuyamba insulin pokhapokha pakufunika. Odwala otere ayenera kupitiliza kugwiritsa ntchito mlingo wapitawu wa mankhwalawo ndipo nthawi yomweyo amayamba kugwiritsa ntchito Mlingo wa insulin yaying'ono, mtsogolomo amaloledwa kuwonjezeka pang'onopang'ono molingana ndi kuchuluka kwa kubwezeretsa kwa metabolic.

Kugawa kwa tsiku ndi tsiku

Nthawi zambiri zimakhala zokwanira kuti thupi limwe kumwa kamodzi tsiku lililonse musanadye kapena chakudya cham'mawa. Wodwalayo akaiwala kumwa mlingo wotsatira, ndiye kuti mlingo wotsatira sufunikira kuchuluka.

Pambuyo kusintha kusintha

Pa chithandizo, kuchuluka kwa chidwi cha insulin ndi kuchepetsedwa kufunika kwa glimepiride. Chifukwa chake, kupewa hypoglycemia Mlingo uyenera kuchepetsedwa mokwanira kapena kusiya mankhwala. Ndi kuwonjezeka kapena kuchepa kwa thupi, masinthidwe a moyo kapena mawonekedwe a zinthu zina zomwe zimawonjezera chiopsezo cha hypoglycemia kapena hyperglycemia, ndikofunikira kuunikanso kuchuluka kwa mankhwalawa.

Kusintha kuchokera kwa othandizira ena am'magazi a hypoglycemic kupita ku Amix

Mu zoterezi, kuchuluka kwa mphamvu ya mankhwala osokoneza bongo ndi theka la moyo ayenera kukumbukiridwa. M'mbuyomu kugwiritsidwa ntchito kwa nthawi yayitali othandizira odwala matenda ashuga wokhala ndi moyo wautali, tikulimbikitsidwa kuti tiyambe mankhwala a Amix atatha nthawi yotsirizira, popeza zowonjezera ndizotheka.

Kusintha kuchokera ku kutenga insulin kupita ku Amix

Mwapadera, pamene mkhalidwe wa odwala omwe ali ndi matenda a shuga a 2 awongoleredwa insulin, Zizindikiro zitha kuwoneka ngati zisinthira ku glimepiride. Kusintha kwa Amix mwa odwalawa kuyenera kuchitika moyang'aniridwa ndi dokotala.

Bongo

Pambuyo mankhwala osokoneza bongo, maonekedwe a hypoglycemia, yomwe imatha kukhala maola 12 mpaka masiku atatu. Kuchipatala kuchipinda chonse kumalimbikitsidwa.Zizindikiro zakuchulukirapo zingaphatikizepo kusanza kapena nseru, kupweteka kwam'mimba, kukalamba, kuwona kwamaso, kugwedezeka kusokonezeka kwa mgwirizano, kugona, kusowa tulo, chikomokerendi kukokana.

Njira zochizira bongo zimagwiritsa ntchito matumbo, kumwa madzi, kaboni yodziyambitsa ndi sodium sulfate. Komanso, mapema momwe muyenera, muyenera kuyamba kugwiritsa ntchito shuga. Mankhwala ena ayenera kukhala oonetsa.

Kuchita

Akaphatikizidwa ndi Phenylbutazone, Azapropazone, Metformin, Oxyphenbutazone, insulin, pakamwa antidiabetic othandizira, salicylates, anabolic steroid, androgens, coumarin-mtundu anticoagulants, chloramphenicol, Fenfluramine, fibratins, Acidumoliponofilinininininininininininhypoglycemia ndizotheka.

Ndikugwiritsa ntchito estrogens, saluretics, progestogens, thiazide diuretics, glucocorticoids, mankhwala othandizira ku chithokomiro, zotumphukira za phenothiazine (Adrenaline, Chlorpromazine), sympathomimetics, nicotinic acid Ndi zotuluka zake, zodyeka, Phenytoin, Glucagon, Diazoxide, Rifampicin, Barbiturates, Acetosolamidezotheka kufooketsa mphamvu ya mankhwala ndi kuwonjezeka kwa kuchuluka kwa shuga m'magazi.

Glimepiridezosintha monga mankhwala osokoneza bongo a coumarin.

Malangizo apadera

Kumayambiriro kwenikweni kwa chithandizo, wodwalayo angakulitse chiopsezo cha hypoglycemia- izi zimafuna kuwunikira mosamala mkhalidwe wake. Zomwe zimapangitsa kuti shuga ya m'magazi azikhala ndi kuchuluka kwa shuga m'magazi ndi monga: kusakhazikika kwa zakudya, zolakwika za kadyedwe, kuperewera kwa zakudya m'thupi, kudya kwambiri, komanso kudumpha zakudya.

Amipyrid, Amaril, Glayri, Glemaz, Glianov, Glimaks, Glinova, Glyrid, Dimaril, Diapirid, Altar, Perinel, Elgim.

Palibe zokuchitikirani ndi kugwiritsa ntchito mankhwalawa kwa ana.

Pa mimba ndi mkaka wa m`mawere

Amayi oyembekezera omwe amamwa mankhwalawa amasamutsidwa kumankhwala insulin

Ngati wodwala akufunika kutenga insulin, akulangizidwa kukana mkaka wa m'mawere.

Zomwe mungagwiritse ntchito mankhwalawa sizokwanira kupanga chithunzi chogwira ntchito. Pakadali pano, ma fanizo am'kamwa a mankhwalawa amagwiritsidwa ntchito nthawi zambiri. Zotengera ndalama glimepiride ndi mankhwala osankha a matenda ashuga mtundu wachiwiri ndikuthandizira kupatula ntchito jakisoni wa insulin. Mukamagwiritsidwa ntchito pazovomerezeka, zotsatira zoyipa ndizochepa.

AMIX vet HTTs (AMIX vet STS)

Dzina lamalonda la mankhwala: AMIX ™ Vet CTZ 150 mg / g (AMIX ™ Vet STS 150 mg / g).

Mayina osayenerera apadziko lonse: chlortetracycline.
Fomu ya Mlingo: ufa wowonjezera pakamwa.
AMIX ™ Vet XTC 150 mg / g ili mu 1 g monga mankhwala othandizira: chlortetracycline - 150 mg (monga chlortetracycline hydrochloride), monga zinthu zothandiza: zopatsa mphamvu za Streptomyces aureofaciens ndi ufa wa tirigu mpaka 1 g.
Mukuwoneka, AMIX ™ Vet XTC 150 mg / g ndi ufa kuchokera ku bulauni wowala mpaka woderapo.
AMIX ™ Vet XTC 150 mg / g imapezeka m'matumba ojambulira atatu osanjikiza atatu okhala ndi polyethylene kapena matumba osanjikiza angapo.
AMIX ™ Vet XTC 150 mg / g imasungidwa mmatumba osindikiza opanga, mosiyana ndi chakudya ndi chakudya, pamalo owuma, amdima pa 2 2 C mpaka 25 ° C.
AMIX ™ Vet XTC 150 mg / g iyenera kusungidwa kuchokera kwa ana.
Mankhwala osagwiritsidwa ntchito amatayidwa malinga ndi zofunikira mwalamulo.

Katundu

AMIX ™ Vet CTZ 150 mg / g ndi mankhwala ochepetsa mphamvu ya gulu la tetracycline.
Chlortertracycline, yomwe ndi gawo la mankhwalawa imakhala ndi chitetezo chambiri cha antibacterial, amagwira ntchito motsutsana ndi gram-virus komanso gram-negative tizilombo, kuphatikizapo Escherichia coli, Klebsiella pneumoniae, Proteus spp., Salmonella spp., Staphylococcus spp. Pasteurella multocida, Streptococci pambali, Rickettsia spp., Chlamydia, Protozoa ndi Mycoplasma spp.
Kupanga kwa bacteriostatic mphamvu ya antibayotiki ndiko kupondereza kapangidwe ka mapuloteni mabakiteriya omwe ali mu khungu laling'ono pamlingo wa ribosomal, womwe umalepheretsa kugawanika ndi kukhazikika kwa khoma la maselo.
Chlortetracycline sichingatengeke konse m'mimba. Mlingo wa mayamwidwe umachepa pamaso pa ma mchere osungunuka amitundu iwiri komanso yaying'ono yama ayoni omwe tetracyclines amapanga khola malo. Chlortetracycline imamangilira bwino mapuloteni a plasma ndipo imagawidwa mthupi lonse, mpaka imafikira kwambiri, m'chiwindi, m'mapapo, m'mapapo komanso malo omwe mafupa amapangika. Kuchuluka kwa tetracycline m'magazi kumafikira maola 4 pambuyo pa kuperekedwa. Zochitika zochizira zimatha maola 12-18. Tetracycline kwenikweni simalowa mumadzi am'mimba, koma mseru wake umatha kuwonjezeka ndikutupa kwa mimbayo. Hafu ya moyo wa chlortetracycline ndi maola 8.8. Amapakidwa makamaka ndi mkodzo ndi ndowe. Ndi ndowe, mpaka 10% ya kuchuluka kwa tetracycline yomwe imalowetsedwa ikhoza kuchotsedwa.

Njira Yogwiritsira Ntchito:

AMIX ™ Vet XTC 150 mg / g imayikidwa ngati nkhumba, anaankhosa, ana amphongo pochiritsa, nkhuku zothandizira kuchipatala ndi matenda ochizira komanso matenda opatsirana a kupuma, dongosolo la genitourinary, matenda am'mimba komanso matenda ena oyamba ndi owonjezera a bakiteriya maukadaulo omwe causative othandizira ake amakhala ndi chidwi ndi chlortetracycline.
AMIX ™ Vet XTC 150 mg / g ndi yoletsedwa kwa achikulire achikulire ndi chimbudzi cham'mimbamo cham'mimba, kuyala nkhuku, komanso nyama zomwe zimakhala ndi aimpso komanso a hepatic.
Lemberani ndi chakudya chamagulu kapena kamodzi patsiku kwa masiku 5 mpaka 10.

Chithandizo cha gulu:
Kuphatikiza 3.0 - 4.0 makilogalamu a mankhwala pa toni imodzi ya zakudya (zomwe zimafanana ndi 450-600 g ya chlortetracycline pa toni ya chakudya kapena 20-30 mg / kg).
Mlingo wa tsiku ndi tsiku wa mankhwala awonetsedwa patebulo:

Kupewa:
Onjezani 1.5-2.0 kg wa mankhwala pa toni imodzi ya zosakaniza (zomwe zimafanana ndi 225-300 g wa chlortetracycline / toni ya chakudya kapena 10-15 mg / kg).

Bongo

Zizindikiro za mankhwala osokoneza bongo sizinadziwikebe.

Zinthu:

Zowoneka machitidwe a mankhwalawa panthawi yomwe amagwiritsidwa ntchito koyamba ndi kusiya sizinakhazikitsidwe.
Kudumpha mlingo wotsatira wa mankhwalawa kuyenera kupewedwa, chifukwa izi zingayambitse kuchepa kwa othandizira. Ngati nthawi yomwe mankhwalawo amagwiritsidwa ntchito mobwerezabwereza siinawonedwe, iyenera kugwiritsidwa ntchito mwachangu, momwemonso mlingo womwewo.
Zotsatira zoyipa, kupatula milandu ya munthu yemwe ali ndi ziwonetsero zina za mankhwala, sizinadziwikebe. Ndi kuchuluka kwa chidwi cha chinyama chlortetracycline ndi mawonekedwe a
Zotsatira za thupi lawo siligwirizana, kugwiritsa ntchito AMIKSTM ve XTC 150 mg / g kuyimitsidwa ndikuchiritsidwa kwa desensitizing.
Musagwiritse ntchito AMIX ™ Vet XTC 150 mg / g molumikizana ndi ma bacteria a bactericidal (penicillin, cephalosporins, etc.), calcium chloride, calcium gluconate, ammonium chloride, antacids, kaolin, zokonzekera zomwe zimakhala ndi chitsulo, magnesium, calcium ndi aluminium. kutsika kotheka kwa ntchito ya antibacterial.
Kupha ana a ng'ombe ndi anaankhosa a nyama saloledwa pasanathe masiku 12, nkhumba ndi nkhuku - patatha masiku 10 atatha kugwiritsa ntchito mankhwalawa. Nyama ya nyama yokakamizidwa kuti iphedwe isanathe nthawi yomwe akuwonetsa ingagwiritsidwe ntchito kudyetsa nyama za ubweya.

Kupewa Kwathu

Mukamapereka mankhwala othandizira komanso kupewa pogwiritsa ntchito mankhwalawa AMIX ™ Vet XTC 150 mg / g, malamulo apadera aukhondo komanso chitetezo choyenera chogwiritsidwa ntchito mukamagwiritsidwa ntchito ndi mankhwala ziyenera kuonedwa.
Mukamaliza ntchito, sambani m'manja ndi madzi ofunda ndi sopo.
Ntchito zonse ndi AMIX ™ Vet XTC 150 mg / g ndikulimbikitsidwa kugwiritsa ntchito zida zodzitetezera (bath bath, headgear, gloves gloves, magalasi otetezeka, kupuma kapena chigoba cha nkhope). Mukugwira ntchito ndi mankhwalawa, ndizoletsedwa kumwa, kusuta ndi kudya chakudya. Mukamaliza ntchito, muyenera kusamba nkhope yanu ndi manja ndi sopo ndi madzi, kutsuka pakamwa panu.
Mukakumana mwangozi ndi pakhungu kapena pakhungu la mucous, muzimutsuka ndi madzi ambiri; ngati mungayang'ane m'maso anu, muzimutsuka mwachangu ndi madzi ndikufunsani dokotala ngati kuli kofunikira.

Moyo wa alumali ndi chosungira:

Alumali moyo wa mankhwalawa mikhalidwe yosungirako mu phukusi losindikizidwa ndi zaka 2 kuyambira tsiku lopangidwa, mutatsegula phukusi - osaposa masiku 28, mu chakudya - osapitilira masiku atatu.

Osagwiritsa ntchito mankhwalawa tsiku likatha.
AMIX ™ Vet XTC 150 mg / g imasungidwa mmatumba osindikiza opanga, mosiyana ndi chakudya ndi chakudya, pamalo owuma, amdima pa 2 2 C mpaka 25 ° C.
AMIX ™ Vet XTC 150 mg / g iyenera kusungidwa kuchokera kwa ana.
Mankhwala osagwiritsidwa ntchito amatayidwa malinga ndi zofunikira mwalamulo.

Mndandanda wonse komanso malangizo azomwe mungagwiritse ntchito popanga Chowona Zanyama zitha kupezeka patsamba lolemba patsamba lanu. Ponena za mtengo, komanso mwayi wakugula mungasangalale kudziwitsa oyang'anira athu.

Sinthani kapangidwe kake

• Piritsi limodzi lamankhwala Konzani 1 ili ndi 1 mg glimepiride.
• Piritsi limodzi lamankhwala Amix 2 ili ndi 2 mg glimepiride.
• Piritsi limodzi lamankhwala Amix 3 ili ndi 3 mg glimepiride.
• Piritsi limodzi lamankhwala Amix 4 ili ndi 4 mgglimepiride.

Zowonjezera zina: povidone 25, lactose, polysorbate 80, microcrystalline cellulose, crospovidone, silicon dioxide, magnesium stearate, iron oxide, utoto.

Amix - Malangizo ogwiritsira ntchito

Zomwe zimayambira bwino pakudya: kudya, kuchita zolimbitsa thupi pafupipafupi komanso kuyang'anira magazi ndi mkodzo nthawi zonse. Mlingo wa mankhwalawa umatsimikiziridwa ndi zotsatira za kusanthula.

Mlingo woyambirira wa mankhwalawa ndi 1 mg ya glimepiride tsiku lililonse. Mlingo womwewo umagwiritsidwa ntchito ngati chithandizo chothandizira mukakwaniritsa kuyang'anira mkhalidwe wa wodwalayo.

Ngati mphamvu yakuyang'anira wodwala siyingatheke, mlingo umawonjezeka ndi 1, 3 kapena 2 mg ya glimepiride tsiku lililonse lililonse mpaka milungu iwiri.

Kutenga glimepiride zoposa 4 mg pa tsiku kumapereka kusintha pokhapokha pokhapokha. Mulingo waukulu mpaka 6 mg ya mankhwalawa patsiku.

Odwala popanda chindapusa chododometsa cha metabolism, ngakhale mutadya kwambiri Mlingo, mankhwala a insulin angayambike pokhapokha ngati pakufunikira. Odwala otere ayenera kupitiliza kugwiritsa ntchito mlingo wapitawu wa mankhwalawo ndipo nthawi yomweyo amayamba kugwiritsa ntchito Mlingo wa insulin yaying'ono, mtsogolomo amaloledwa kuwonjezeka pang'onopang'ono molingana ndi kuchuluka kwa kubwezeretsa kwa metabolic.

Kugawa kwa tsiku ndi tsiku

Nthawi zambiri zimakhala zokwanira kuti thupi limwe kumwa kamodzi tsiku lililonse musanadye kapena chakudya cham'mawa. Wodwalayo akaiwala kumwa mlingo wotsatira, ndiye kuti mlingo wotsatira sufunikira kuchuluka.

Pambuyo kusintha kusintha

Pa chithandizo, kuwonjezeka kwa insulin sensitivity ndi kuchepa kwa kufunika kwa glimepiride ndikotheka. Chifukwa chake, pofuna kupewa hypoglycemia, mlingo uyenera kuchepetsedwa mokwanira kapena mankhwalawo ayenera kusiyidwa. Ndi kuwonjezeka kapena kuchepa kwa thupi, kusintha kwa moyo, kapena zinthu zina zomwe zimawonjezera chiopsezo cha hypoglycemia kapena hyperglycemia, ndikofunikira kuunikanso kuchuluka kwa mankhwalawa.

Kusintha kuchokera kwa othandizira ena am'magazi a hypoglycemic kupita ku Amix

Mu zoterezi, kuchuluka kwa mphamvu ya mankhwala osokoneza bongo ndi theka la moyo ayenera kukumbukiridwa. Pogwiritsa ntchito zakale antidiabetesic othandizira omwe ali ndi moyo wautali, tikulimbikitsidwa kuti tiyambitse mankhwala a Amix atatha nthawi yotsiliza, popeza zowonjezera ndizotheka.

Kusintha kuchokera ku kutenga insulin kupita ku Amix

Mwapadera, pamene mkhalidwe wa odwala omwe ali ndi matenda amtundu wa 2 wakhazikitsidwa ndi insulin, zikuwonetsa kuti kusinthana ndi glimepiride kumachitika. Kusintha kwa Amix mwa odwalawa kuyenera kuchitika moyang'aniridwa ndi dokotala.