Gensulin P (Gensulin R)

yogwira pophika: 1 ml ya yankho ili ndi zomwe zimapangidwanso ndi insulin 100 PESCES

excipients: m cresol, phenol, glycerin protamine zinc sulfate oxide, sodium dihydrogen phosphate dihydrate, hydrochloric acid (kuchepetsedwa) madzi a jekeseni.

Kuyimitsidwa kwa jakisoni.

Zofunikira zathupi:

Kuyimitsidwa koyera, komwe kuyimitsidwa kumasiyanitsidwa ndi koyera koyera ndi madzi opanda mtundu kapena pafupifupi. Vial kapena cartridge silingagwiritsidwe ntchito ngati, mutatha kusuntha, kuyimitsidwa kumakhala kumveka bwino kapena ngati kuyera koyera kumangidwa pansi. Simungagwiritse ntchito mankhwalawa ngati mutasakaniza mu botolo kapena makatoni oyandama kapena tinthu tating'onoting'ono timakhalabe pamakoma achombo, chifukwa chomwe mankhwalawo amawoneka ngati achisanu.

Mankhwala.

Gensulin H ndi makonzedwe obwerezabwereza a isofan-insulin opangidwa ndi majini pogwiritsa ntchito majini osinthika, koma osati tizilombo toyambitsa matenda a E. coli. Insulin ndi mahomoni opangidwa ndi maselo a pancreatic. Insulin imakhudzidwa ndi kagayidwe kazachilengedwe, mapuloteni ndi mafuta, zomwe zimapangitsa, makamaka kuchepa kwa kuchuluka kwa shuga m'magazi. Kuperewera kwa insulin m'thupi kumayambitsa matenda ashuga. Insulin, yoyendetsedwa ndi jakisoni, imachitanso chimodzimodzi ndi mahomoni opangidwa ndi thupi.

Gensulin N amayamba kugwira ntchito pasanathe mphindi 30 kuchokera pakukhazikitsidwa, kuchuluka kwakukulu kumawonedwa kuyambira 2 mpaka 8:00, ndipo nthawi yochitapo imafika mpaka maola 24 ndipo zimatengera mlingo. Mwa anthu athanzi, mpaka 5% a insulini imagwirizanitsidwa ndi mapuloteni amwazi. Kupezeka kwa insulin m'madzi am'magazi mu kutsekeka kwa pafupifupi 25% yazinthu zomwe zimapezeka mu seramu yamagazi kunadziwika.

Insulin imapukusidwa mu chiwindi ndi impso. Zochepa zimapangidwa mu minofu ndi minofu ya adipose. Odwala omwe ali ndi matenda ashuga, kagayidwe kamadutsa monga mwa athanzi. Insulin imachotsedwa impso. Mafuta amatsitsidwa mu ndulu. Hafu ya moyo wa insulin ya anthu pafupifupi mphindi 4. Matenda a impso ndi chiwindi zimachedwetsa kutulutsidwa kwa insulin. Mu okalamba, kutulutsidwa kwa insulin kumayamba pang'onopang'ono ndipo nthawi ya Hypoglycemic imayamba.

Makhalidwe azachipatala

Chithandizo cha odwala matenda a shuga mellitus, omwe amafunikira kugwiritsa ntchito insulin.

Hypoglycemia. Hypersensitivity kwa mankhwala Gensulin N ndi chilichonse cha zigawo zake, kupatula milandu ya desensitizing mankhwala. Osamayendetsa mitsempha.

Njira zapadera zotetezera

Osagwiritsa ntchito Gensulin H:

• ngati cartridge kapena syringe cholembera yagwera kapena wakumana ndi mavuto akunja, popeza pali chiopsezo chowonongeka kwa iwo ndi kutayikira kwa insulin,
• ngati idasungidwa molakwika kapena yowuma,
• ngati madzi ali m'matumbo si ofanana.

Kumwa mowa kungayambitse kuchepa koopsa kwa shuga m'magazi.

Kuyanjana ndi mankhwala ena ndi mitundu ina yoyanjana.

Dokotalayo ayenera kudziwitsidwa za chithandizo chilichonse chothandizidwa molumikizana ndi kugwiritsa ntchito insulin ya anthu.

Gensulin N sayenera kusakanikirana ndi insulin ya nyama, komanso ma biosynthet insulin a opanga ena. Mankhwala ambiri (makamaka, ma antihypertensives ndi mankhwala a mtima, mankhwala omwe amachepetsa ma seramu lipids, mankhwala ogwiritsidwa ntchito pancreatic matenda, antidepressants, antiepileptic mankhwala, salicylates, antibacterial mankhwala, pakamwa kulera) angakhudze zotsatira za insulin ndi Mphamvu ya insulin mankhwala.

Mankhwala ndi zinthu zomwe zimachulukitsa zochita za insulin b-adrenolytics, chloroquine, angiotensin converase inhibitors, mao inhibitors (antidepressants), methyldopa, clonidine, pentamidine, salicylates, anabolic steroids, cyclophosphamide, sulfanilamides, tetracycline.

Mankhwala osokoneza bongo omwe amachepetsa zotsatira za insulin, diltiazem, dobutamine, estrogens (komanso mankhwala oletsa kubereka pakamwa), phenothiazines, phenytoin, mahomoni a pancreatic, heparin, calcitonin, corticosteroids, mankhwala oletsa kugwiritsidwa ntchito pothana ndi matenda a HIV, niacin, thiazide diuretics.

Kufunika kwa insulin kumatha kuwonjezeka ndi kugwiritsa ntchito mankhwala omwe ali ndi vuto la hyperglycemic, mwachitsanzo, glucocorticoids, mahomoni a chithokomiro komanso mahomoni okula, danazol, b ₂ sympathomimetics (mwachitsanzo, ritodrin, salbutamol, terbutaline), thiazides.

Kufunika kwa insulini kumatha kuchepa komanso kugwiritsa ntchito mankhwala omwe ali ndi vuto la hypoglycemic, monga mankhwala amkamwa a hypoglycemic, salicylates (mwachitsanzo acetylsalicylic acid), ma antidepressants (MAO inhibitors), ma Aitor inhibitors ena (Captopril, enalapril), osasankha beta-blockers kapena mowa.

Pankhani yogwiritsidwa ntchito pamodzi kwa Gensulin MZ0 ndi pioglitazone, kuwonetsa kulephera kwa mtima ndikotheka, makamaka kwa odwala omwe ali ndi chiopsezo cha mtima kulephera. Ngati kuphatikiza uku kumagwiritsidwa ntchito, wodwala amayenera kuwonedwa ngati zizindikiro ndi zizindikiro zakulephera kwa mtima, kunenepa kwambiri, komanso edema. Kuchiza ndi pioglitazone kuyenera kusiyidwa ngati chizindikiro cha mtima chikukulirakulira.

Zomwe zimagwiritsidwa ntchito.

Ndi madokotala okha omwe angapange chisankho pakusintha kwa dosing regimen, kusakaniza kukonzekera kwa insulin, ndikusinthanso kuchokera kukonzekera kwa insulin ina. Lingaliro lotere limapangidwa moyang'aniridwa ndi achipatala mwachindunji ndipo lingakhudze kusintha kwa mlingo wogwiritsidwa ntchito. Ngati pakufunika kusintha kwa kumwa kwa mankhwalawa, kusintha koteroko kutha kuchitika kuchokera pa mlingo woyamba kapena pambuyo pake kwa milungu ingapo kapena miyezi. Odwala amayesedwa pakhungu asanayambe mankhwala ndi mankhwala atsopano, kuphatikizira omwe adakhudzanso insulin. Mukamagwiritsa ntchito insulin, yang'anani kuchuluka kwa shuga mu seramu ndi mkodzo, kuchuluka kwa glycosylated hemoglobin (HLA1c) ndi fructosamine. Odwala ayenera kuphunzitsidwa kudziyimira pawokha kuchuluka kwa shuga m'magazi ndi mkodzo pogwiritsa ntchito mayeso osavuta (mwachitsanzo, zingwe zoyeserera). Mwa anthu osiyanasiyana, Zizindikiro zakuchepa kwa shuga m'magazi (hypoglycemia) zimatha kuwoneka nthawi zosiyanasiyana ndipo zimakhala zosiyanasiyana. Chifukwa chake, odwala ayenera kuphunzitsidwa kuti azindikire mawonekedwe awo a hypoglycemia. Odwala omwe amasintha mtundu wa insulin yomwe imagwiritsidwa ntchito, ndiye kuti, amawasamutsa kuchokera ku insulin yomwe adachokera ku nyama kupita ku insulin yaumunthu, zingakhale zofunikira kuti muchepetse insulin (chifukwa cha hypoglycemia). Mwa odwala ena, zizindikiro zoyambirira za hypoglycemia pambuyo poti zimasinthananso ndi insulin yaumunthu zimatha kuchepa pang'ono kuposa momwe zimagwiritsira ntchito insulin yochokera ku nyama.

Kufunika kwa insulin kungasinthe chifukwa cha kutentha kwambiri, matenda akulu (kufunika kwa insulini kumatha kuwonjezeka), zokumana nazo, matenda ndi zovuta zam'mimba, limodzi ndi mseru komanso kusanza, kutsegula m'mimba, kudzimbidwa, komanso kuperewera kwa masabsorption. Kukhalapo kwa zinthu zotere nthawi zonse kumafuna kuti dokotala alowerere. Zikatero, kuchuluka kwa shuga m'magazi ndi mkodzo kuyenera kuyang'aniridwa nthawi zambiri. Pakulephera kwa impso, insulin katulutsidwe amachepetsa, ndipo nthawi yake imakula.

Odwala omwe ali ndi matenda osokoneza bongo omwe amaphatikizidwa ndi matenda a kapamba kapena kuphatikizana ndi matenda a Addison kapena kuperewera kwa pituitary amatenga insulin kwambiri, ndipo, monga lamulo, ayenera kupatsidwa mankhwala ochepa kwambiri a mankhwalawa.

Pogwiritsa ntchito chovala chamchiberekero cha ziwalo, kapamba, adrenal gland, chithokomiro cha chithokomiro, kapena chiwindi kapena matenda a impso, kufunika kwa insulin kungasinthe.

Ma antibodies amatha kupangidwa mu mankhwalawa a insulin ya anthu, makamaka pazotsika kuposa poyerekeza ndi insulin yanyama.

Pa chithandizo cha insulin yayitali, insulin imayamba. Pankhani ya kukana insulini, mulingo waukulu wa insulin uyenera kugwiritsidwa ntchito.

Kuchepetsa dosing kapena kuyimitsidwa kwa chithandizo (makamaka kwa odwala omwe ali ndi matenda osokoneza bongo omwe amadalira insulin) kungayambitse matenda a hyperglycemia komanso matenda oopsa a matenda ashuga a ketoacetosis. Kufunika kwa kusintha kwa mlingo kumatha kuchitika ngati pakuchitika masinthidwe azolimbitsa thupi kapena zakudya wamba.

Anthu omwe akukonzekera kupanga maulendo ataliitali posintha magawo angapo akuyenera kufunsa adokotala kuti asinthe dongosolo la kumwa insulini.

Gwiritsani ntchito pa nthawi yoyembekezera kapena mkaka wa m'mawere.

Insulin sichidutsa chotchinga.

Kwa odwala omwe matenda ashuga anakula asanabadwe kapena panthawi yomwe ali ndi pakati (gestationalabetes), ndikofunikira kuti azisamalira kagayidwe kake ka zakudya mthupi nthawi yonse yomwe ali ndi pakati.

Palibe choletsa kugwiritsa ntchito mankhwala Gensulin N panthawi yoyamwitsa. Komabe, amayi pa nthawi yoyamwitsa angafunikire kusintha kwa kadyedwe komanso kadyedwe.

Kutha kukopa momwe zinthu zikuyendera mukamayendetsa magalimoto kapena njila zina

Kutha kuyendetsa magalimoto kumatha kuwonongeka kudzera mu hypoglycemia, komwe kumayambitsa kusokonezeka kwa zotumphukira zamagetsi ndipo kumayendetsedwa ndi mutu, nkhawa, diplopia, kusokonezeka kwa mayanjano ndi kuyerekeza mtunda. Munthawi yoyambirira ya mankhwala a insulin, posintha mankhwalawa (ngati mukupanikizika kapena mukuchita zolimbitsa thupi kwambiri, pakakhala kusinthasintha kwakukulu pakuphatikizidwa kwa shuga m'magazi), kufooka kwa kuthekera koyendetsa magalimoto ndikusunga zida poyenda zitha kuwoneka. Ndikulimbikitsidwa kuwongolera kuchuluka kwa shuga m'magazi paulendo wautali.

Mlingo ndi makonzedwe.

Muzochita zamankhwala, machitidwe ambiri othandizira odwala insulin aumunthu amadziwika. Kusankha pakati pawo, njira yomwe munthu aliyense angagwirire nayo wodwala wina, iyenera kupangidwa ndi adokotala potengera kufunika kwa insulin. Kutengera kukhazikika kwa shuga wamagazi, adokotala amawona mlingo woyenera ndi mtundu wa kukonzekera kwa insulin kwa wodwala wina.

Gensulin N ndi ya jakisoni wotsekemera. Mwapadera, ikhoza kutumikiridwa intramuscularly. Gensulin N imayendetsedwa mphindi 15-30 asanadye. Mphindi 10-20 dongosolo lisanakonzedwe, insulini iyenera kupezeka mufiriji kuti izitha kutentha kutentha kwa chipinda.

Asanayambe makonzedwe, muyenera kuyang'anitsitsa vial kapena cartridge ndi insulin. Kuyimitsidwa kwa Gensulin H kuyenera kukhala opaque yofanana (mwamphamvu mitambo kapena yamaonekedwe owala). Vial kapena cartridge silingagwiritsidwe ntchito ngati, mutatha kusuntha, kuyimitsidwa kumakhala koyera kapena mawonekedwe oyera oyera pansi. Simungagwiritsenso ntchito mankhwalawa ngati, mutasakaniza mu botolo kapena makatoni, ma ntchentche oyera amayandama kapena tinthu tating'onoting'ono timatsalira pamakoma achombo, chifukwa chomwe mankhwalawo akuwoneka kuti achisanu. Makamaka chidwi chake chikuyenera kulipidwa kuti zitsimikizidwe kuti panthawi ya jakisoni wa insulin, singano yake siliikidwa mu lumen ya mtsempha wamagazi.

Kukhazikitsa kwa mankhwala pogwiritsa ntchito ma syringes.

Pakukhazikitsa insulin, pali ma syringe ena apadera omwe ali ndi cholembera. Pakapanda kugwiritsa ntchito ma syringe ndi singano, kugwiritsa ntchito ma syringe angapo ndi singano, zomwe zingagwiritsidwe ntchito chosawilitsidwa musanabaye chilichonse. Ndikulimbikitsidwa kugwiritsa ntchito ma syringes amtundu womwewo ndikupanga. Ndikofunikira nthawi zonse kuyesa syringe yomwe yamaliza kugwiritsa ntchito, malinga ndi kuchuluka kwa mankhwala omwe amapanga insulin.

Ndikofunikira kujambula botolo la Gensulin N m'manja mwa manja mpaka kuyimitsidwa kumakhala kofanana, kwamtambo kapena kwamawonekedwe.

Dongosolo la jakisoni:

• chotsani mphete yodzitchinjiriza yomwe ili pakatikati pa kapu,
• ikani mu syringe ya mpweya yokhala ndi voliyumu yofanana ndi mlingo wa insulin,
• kuboola poyimitsa mphira ndikulowetsa mpweya
• sinthanitsani botolo ndi syringe pansi,
• onetsetsani kuti kutha kwa singano kuli mu insulin,
• jambulani kuchuluka kwa insulin yothetsera syringe,
• Chotsani zotumphukira zam'mlengalenga mu vial ndi jakisoni wa insulin,
• onaninso kulondola kwa mlingo ndikuchotsa singano mu vial,
• yochotsa khungu pamalo pomwe jekeseni wakonzekera,
• khazikitsani khungu ndi dzanja limodzi, ndiye kuti pindani,
• tengani syringe mbali inayo ndikuigwira ngati pensulo. Ikani singano pakhungu pakona kumanja (90 °).

Kuphatikiza kuyimitsidwa kwa Gensulin N ndi yankho la Gensulin R.

Lingaliro la kusakaniza Gensulin H ndi yankho la pamwambapa ndi kuyimitsidwa kwake kungachitike kokha ndi dokotala.

Kugwiritsidwa ntchito kwa Gensulin N mu katiriji wama syringe pens.

Makatiriji a Gensulin H angagwiritsidwe ntchito ndi ma syringes osinthika. Mukadzaza cholembera, kupangira singano ndi njira yothandizira jakisoni, malangizo a wopanga cholembera uyenera kuyang'aniridwa. Ngati ndi kotheka, mutha kukoka insulini kuchokera ku cartridge kupita ku syringe yokhazikika ndikuchita monga tafotokozera pamwambapa (kutengera kuchuluka kwa insulin ndi mtundu wa mankhwala).

Gensulin N inayimitsidwa iyenera kusakanizika musanalowetse jekeseni iliyonse pakugwedeza mpaka nthawi 10 kapena kusunthira m'manja mpaka manja atayimitsidwa.

Palibe chokwanira chokwanira ndi mankhwalawa kwa ana.

Bongo.

Pankhani ya insulin yochulukirapo, zizindikiro za hypoglycemia zimawonekera, makamaka kumverera kwa njala, kusowa chidwi, chizungulire, kunjenjemera kwa minofu, kusokonezeka, kuda nkhawa, kulumala, kuchuluka thukuta, kusanza, kupweteka mutu, ndi chisokonezo.

Mitundu ikuluikulu ya hypoglycemia imatha kuyambitsa kukopeka ndi kusazindikira, ngakhale kufa. Wodwala akakhala kuti akula, ndikofunikira kupaka shuga m'mitsempha. Pambuyo pa insulin yochuluka ya hypoglycemia, zizindikiro za hypokalemia (kuchepa kwa kuchuluka kwa potaziyamu m'magazi) zitha kujowina, kenako myopathy. Ndi hypokalemia yayikulu, pomwe wodwalayo sangathenso kudya mkamwa, 1 mg ya glucagon iyenera kutumikiridwa ndi intramuscularly ndi / kapena njira ya glucose yolumikizira. Akadzazindikira, wina ayenera kudya. Zingafunikenso kupitiliza kupatsa chakudya odwala ndi kuwunikira kuwunika kwamisempha yamagazi, chifukwa hypoglycemia imatha kuonekera atachira.

Zochita Zosiyana

Hypoglycemia. Hypoglycemia nthawi zambiri zimakhala zotsatira zoyipa zomwe zimachitika ndi insulin.Zimachitika pamene mlingo wa insulini wothandizidwa mopitirira kuposa momwe umafunikira. Kuukira kwambiri kwa hypoglycemia, makamaka ngati kumachitika kangapo konse, kumatha kuwononga dongosolo lamanjenje. Hypoglycemia yomwe imakhalapo kwa nthawi yayitali kapena yoopsa imatha kusokoneza moyo wa wodwalayo.

Zizindikiro za hypoglycemia wolimbitsa thupi: thukuta kwambiri, chizungulire, kuthamanga, kugona, kusamva, kugontha, kugona, kusokonezeka, kusokonezeka, malingaliro, kusokonezeka pakulankhula, kukhumudwa, kusakhazikika. Zizindikiro za hypoglycemia: kusokonezeka, kukhumudwa, kupweteka.

Odwala ambiri, kuyambika kwa chizindikiritso cha kusakwanira kwa glucose ku minofu yaubongo (neuroglycopenia) kumayambitsidwa ndi zizindikiro za kutsutsana ndi adrenergic.

Kuchokera kumbali ya ziwalo zamasomphenya. Kusintha kwakukulu kwa shuga m'magazi kumatha kubweretsa kuwonongeka kwakanthawi chifukwa cha kusintha kwakanthawi kwa turgor ndi kupindika kwa mandala.

Chiwopsezo cha kupita patsogolo kwa matenda ashuga retinopathy amachepetsa pomwe kuyamwa kwakanthawi glycemic kumatheka. Komabe, kuchuluka kwa insulin mankhwala ndi kuchepa msanga m'magazi kungayambitse kufooka kwa maphunziro a matenda ashuga retinopathy. Odwala omwe ali ndi retinopathy yowonjezereka, makamaka omwe sanatengepo laser Photocoagulation, zovuta za hypoglycemic zimatha kuyambitsa khungu.

Lipodystrophy. Monga insulin ina iliyonse, lipodystrophy imatha kupezeka pamalo a jakisoni, chifukwa cha momwe kuchuluka kwa mayamwidwe a insulin kumalo opangira jakisoni kumachepera. Kusintha kwa jekeseni pafupipafupi mu tsamba limodzi la jakisoni kumatha kuchepetsa izi kapena kulepheretsa kuchitika kwawo.

Zokhudza malo jakisoni ndi thupi lawo siligwirizana. Zotsatira zoyipa za jakisoni ndi zimachitika zonse, kuphatikiza khungu, kutupa, kutupa, kupweteka, kuyabwa, urticaria, kutupa, kapena kutupa, Zochita zambiri zofewa za insulin zomwe zimapezeka jakisoni jekeseni zimatha nthawi yayitali kuchokera masiku angapo mpaka milungu ingapo.

Mitundu yosiyanasiyana ya ziwengo insulin, kuphatikiza milandu yayikulu, kuphatikiza mafinya padziko lonse lapansi, kufupika, kupindika, kutsika magazi, kuchuluka kwa mtima, kuchuluka kwa thukuta.

Maganizo a Hypersensitivity nthawi yomweyo amakhala osowa kwambiri. Kuwonetsedwa kotereku kwa insulin kapena ma excipients, mwachitsanzo, kusintha pakhungu, angioedema, bronchospasm, ochepa hypotension ndi mantha, zomwe zitha kuwopsa pamoyo wa wodwalayo.

Zina. Kukhazikitsidwa kwa kukonzekera kwa insulin kungayambitse kupanga kwa antibodies kwa iwo. Nthawi zina, chifukwa cha kupezeka kwa ma antibodies ku insulin, pangafunike kusintha kwa mankhwalawa kuti mupewe hypo- kapena hyperglycemia.

Insulin imatha kuyambitsa kuchepa kwa sodium ya thupi ndi mawonekedwe a edema, makamaka ngati, chifukwa cha kuchuluka kwa insulini chithandizo, ndizotheka kusintha kayendedwe ka glycemic, komwe mpaka pamenepo sikunakhale kokwanira.

Malo osungira

Mutatsegula, sungani ma CD kwa masiku 42 pa kutentha osaposa 25 ° C. Sungani kutentha kwa 2-8 ° C pamalo amdima. Osamawuma. Pewani kufikira ana.

Monga lamulo, insulini imatha kuwonjezeredwa ku zinthu zomwe zimachitika pakadali pano. Mankhwala omwe amawonjezeredwa ndi insulin angayambitse chiwonongeko chake, mwachitsanzo, kukonzekera komwe kumakhala ndi thiols kapena sulfites.

10 ml mumabotolo amgalasi okhala ndi cholembera ndi chopondera cha aluminium No. 1, 3 ml m'mathumba No. 5.

Malo

Adilesi yazamalamulo: Bioton S.A., Poland, 02-516, Warsaw, ul. Starochinska, 5 (VIOTON SA, Poland, 02-516, Warsaw, 5 Staroscinska str.).

Adilesi Yopanga: Bioton S.A., Machezhish, ul. Poznan, 12 05-850, Ozarow Mazowiecki, Poland (BIOTON SA, Macierzysz, 12 Poznanska Street, 05-850 Ozarow Mazowiecki).

Gulu la Nosological (ICD-10)

Mankhwala

Gensulin P - insulin yaumunthu yomwe idagwiritsidwa ntchito pogwiritsa ntchito ukadaulo wa DNA. Ndikukonzekera mwachidule insulin. Imalumikizana ndi cholandirira chapadera pa cell ya cytoplasmic ya maselo ndikupanga insulin receptor zovuta zomwe zimapangitsanso zochitika zina, kuphatikizapo kaphatikizidwe angapo ofunikira a michere (kuphatikizapo hexokinase, pyruvate kinase, glycogen synthetase). Kutsika kwa shuga m'magazi kumachitika chifukwa chophatikizira kuchulukitsa kayendedwe kake ka chidwi, kupititsa patsogolo minofu ndi kugwirira ntchito, kulimbikitsa lipogenesis, glycogenogeneis, ndikuchepetsa kuchuluka kwa shuga m'magazi.

Kutalika kwa nthawi ya kukonzekera kwa insulin kumachitika makamaka chifukwa cha kuchuluka kwa mayamwidwe, zomwe zimatengera zinthu zingapo (mwachitsanzo, mlingo, njira ndi malo oyang'anira), chifukwa chake zochitika za insulin zimasinthasintha kwambiri, mwa anthu osiyanasiyana komanso kwa munthu yemweyo .

Mbiri yamachitidwe ndi subcutaneous jakisoni (pafupifupi chiwerengero): kuyambika kwa mphindi 30, mphamvu yayitali imakhala pakatikati pa maola 1 ndi 3, nthawi yayitali mpaka maola 8.

Pharmacokinetics

Kutsiriza kwa mayamwa ndi kuyambika kwa mphamvu ya insulin kumadalira kuchokera pamalowo jakisoni (m'mimba, ntchafu, matako), mlingo (kuchuluka kwa insulin), kuchuluka kwa insulin. Imagawidwa mosiyanasiyana munsiyo: simalowerera chotchinga ndi mkaka wa m'mawere. Imawonongeka ndi insulinase, makamaka m'chiwindi ndi impso. Imafufutidwa ndi impso (30-80%).

Zisonyezero za mankhwala Gensulin P

mtundu 1 shuga

lembani matenda ashuga a 2 matenda a shuga: gawo lolimbana ndi mankhwalawa a pakamwa.

mwadzidzidzi zinthu odwala matenda a shuga, limodzi ndi kuwonongeka kwa chakudya.

Zotsatira zoyipa

Chifukwa cha kuchuluka kwa kagayidwe kazakudya: hypoglycemic zinthu (pallor of the khungu, thukuta kwambiri, palpitations, kugwedeza, njala, kukwiya, paresthesia mkamwa, mutu). Matenda oopsa a hypoglycemia angayambitse kukula kwa chikomokere kwa hypoglycemic.

Zotsatira zoyipa: kawirikawiri - zotupa pakhungu, edema ya Quincke, yosowa kwambiri - kuwopsa kwa anaphylactic.

Zomwe zimachitika: Hyperemia, kutupa ndi kuyabwa pamalowo jekeseni, ndikugwiritsa ntchito nthawi yayitali - lipodystrophy pamalo opangira jekeseni.

Zina: kutupa, zolakwika zosakhalitsa (nthawi zambiri kumayambiriro kwa mankhwala).

Kuchita

Hypoglycemic zotsatira za insulin patsogolo mankhwala m'kamwa hypoglycemic, Mao zoletsa, zoletsa Ace, carbonic zoletsa anhydrase, si kusankha β-blockers, bromocriptine, octreotide, sulfonamides, anabolic mankhwala, tetracyclines, clofibrate, ketoconazole, mebendazole, pyridoxine, theophylline, cyclophosphamide, fenfluramine, kukonzekera lifiyamu kukonzekera kokhala ndi Mowa.

Kulera kwapakamwa, corticosteroids, mahomoni a chithokomiro, thiazide diuretics, heparin, tridclic antidepressants, sympathomimetics, danazole, clonidine, BKK, diazoxide, morphine, phenytoin, nikotini kufooketsa mphamvu ya hypoglycemic.

Mothandizidwa ndi reserpine ndi salicylates, kufooka komanso kuwonjezeka kwa machitidwe a mankhwalawa ndizotheka.

Mlingo ndi makonzedwe

P / K / mu / m ndi / mu. Nthawi zambiri s / c khoma lamkati lakumbuyo. Jekeseni amathanso kuchitidwa m'tchafu, matako, kapena dera lamapeto. Ndikofunikira kusintha malo a jekeseni mkati mwa anatomical dera kuti muchepetse kukula kwa lipodystrophy.

Gensulin Phata ya intramuscular and intravenous imatha kuperekedwa kokha moyang'aniridwa ndi achipatala.

Mlingo ndi njira ya kaperekedwe ka mankhwala imatsimikiziridwa ndi dokotala aliyense payekha, malinga ndi kuchuluka kwa shuga m'magazi. Pafupifupi, tsiku lililonse mlingo wa mankhwalawo umachokera ku 0,5 mpaka 1 IU / kg (kutengera umunthu wa wodwalayo komanso kuchuluka kwa shuga m'magazi).

Mankhwalawa umaperekedwa kwa mphindi 30 asanadye kapena chakudya.

Kutentha kwa insulin yoyenera kuyenera kukhala kutentha kwambiri.

Ndi monotherapy ndi mankhwala, pafupipafupi makonzedwe ndi 3 pa tsiku (ngati ndi kotheka, 5-6 pa tsiku). Pa mlingo wa tsiku ndi tsiku wopitilira 0.6 IU / kg, ndikofunikira kulowa mu mawonekedwe a jekeseni a 2 kapena kuposa m'malo osiyanasiyana a thupi.

Gensulin P imagwira insulini mwachidule ndipo nthawi zambiri imagwiritsidwa ntchito limodzi ndi insulin (Gensulin H).

Malangizo apadera

Simungagwiritse ntchito Gensulin N, ngati mutagwedeza kuyimitsidwa sikuyera koyera komanso kwamitambo.

Poyerekeza ndi maziko a mankhwala a insulin, kuyang'anira kuchuluka kwa shuga m'magazi ndikofunikira.

Zomwe zimayambitsa hypoglycemia kuwonjezera pa insulin yochulukirapo imatha kukhala: kuthana ndi mankhwala, kudumpha chakudya, kusanza, kutsegula m'mimba, kuchuluka kwa zochitika zolimbitsa thupi, matenda omwe amachepetsa kufunikira kwa insulin (chiwindi ndi matenda a impso, hypofunction ya adrenal cortex, pituitary kapena chithokomiro cha chithokomiro), kusintha kwa jekeseni wa jekeseni, komanso kuyanjana ndi mankhwala ena.

Kulephera kapena kusokoneza kwa insulin makonzedwe, makamaka kwa odwala omwe ali ndi matenda amtundu wa 1, angayambitse matenda a hyperglycemia. Nthawi zambiri, zizindikiro zoyambirira za hyperglycemia zimayamba pang'onopang'ono kwa maola angapo kapena masiku. Izi zikuphatikiza ludzu, kukodza kwambiri, nseru, kusanza, chizungulire, khungu ndi kuwuma pakhungu, pakamwa pouma, kusowa chilimbikitso, kununkhira kwa acetone mu mpweya wotuluka. Ngati sanalandire, hyperglycemia mu mtundu 1 wa shuga angayambitse kukula kwa matenda ashuga a ketoacidosis.

Mlingo wa insulin uyenera kukonzedwa kuti matenda a chithokomiro asokonekera, matenda a Addison, hypopituitarism, chiwindi ndi impso ntchito ndi anthu odwala azaka zopitilira 65.

Kuwongolera mlingo wa insulin kungafunikenso ngati wodwala akuwonjezera kuchuluka kwa zolimbitsa thupi kapena asintha zakudya zomwe amakonda.

Matenda onga, makamaka matenda ndi machitidwe omwe amatsatana ndi malungo, amalimbikitsa kufunika kwa insulini.

Kusintha kuchokera ku mtundu wina wa insulin kupita ku wina kuyenera kuchitika mothandizidwa ndi misempha yamagazi.

Mankhwala amachepetsa kulolera kwa mowa.

Chifukwa cha kuthekera kwanyengo m'macepota ena, osavomerezeka kugwiritsa ntchito mankhwalawa kumapampu a insulin.

Kukopa pa kuyendetsa magalimoto ndi kugwira ntchito ndi njira. Pokhudzana ndi cholinga choyambirira cha insulini, kusintha kwa mtundu wake, kapena kupanikizika kwakukulu kwamthupi kapena m'maganizo, ndizotheka kuchepetsa kuyendetsa galimoto kapena kuwongolera njira zosiyanasiyana, komanso kuchita zochitika zina zowopsa zomwe zimafuna chidwi chochulukirapo komanso kuthamanga kwa malingaliro ndi magalimoto.

Kutulutsa Fomu

Kubaya, 100 IU / ml. Mu botolo la galasi lopanda utoto (mtundu 1), wokhathamira ndi cholembera, chopindika, cholumikizidwa ndi chipewa cha aluminium kapena chosavomerezeka, 10 ml. 1 fl. pa kakhadi kadi.

Mu cartridge yamagalasi (mtundu 1), wokhala ndi pistoni ya rabara, chimbale cha mphira, wokulungika mu kapu ya aluminiyamu, 3 ml. Makatoni 5 mumchimake. 1 chithuza chonyamula makatoni.

Kutulutsa mafomu ndi kapangidwe kake

Yankho lomveka bwino, kuyimitsidwa koyera, kuyendetsedwa mosagwirizana. Mtengo ungawonekere kuti umasungunuka mosavuta ukagwedezeka. Mankhwalawa amamuikidwa m'mabotolo 10 ml kapena makilogalamu atatu a 3 ml.

Mu 1 ml ya mankhwalawa, chigawo chogwira ntchito chilipo mu mawonekedwe a recombinant human insulin 100 IU. Zowonjezera zake ndi glycerol, sodium hydroxide kapena hydrochloric acid, metacresol, madzi a jekeseni.

Mu 1 ml ya mankhwalawa, chigawo chogwira ntchito chilipo mu mawonekedwe a recombinant human insulin 100 IU.

Zotsatira za pharmacological

Amatanthauzanso ma insulin osakhalitsa. Pogwira ntchito ndi cholandilira chapadera pa membrane wa cell, imalimbikitsa kupangika kwa insulin-receptor tata, yomwe imayendetsa ntchito mkati mwa cell ndi kapangidwe kazinthu zina za enzyme.

Mlingo wa shuga m'magazi umakhala wolimba pakuwonjezera kuyendetsa kwake m'maselo, kumatheka kwa ziwalo zonse za mthupi, kuchepetsa kupanga shuga ndi chiwindi, komanso kulimbikitsa glycogenogenesis.

Kutalika kwa mankhwalawa zotsatira za mankhwalawa zimatengera:

• mayamwa gawo la yogwira,
• woyendera nthambi ndi njira yoyendetsera thupi,
• Mlingo.

Contraindication

1. Aliyense tsankho kwa zigawo zikuluzikulu za mankhwala.
2. Hypoglycemia.

Momwe mungatenge Gensulin?

Mankhwala chikuyendetsedwera m'njira zingapo - intramuscularly, subcutaneously, kudzera m`mitsempha. Mlingo ndi gawo la jakisoni amasankhidwa ndi dokotala wopezeka kwa wodwala aliyense. Mlingo wokhazikika umasiyanasiyana kuyambira 0,5 mpaka 1 IU / kg ya kulemera kwa munthu, poganizira kuchuluka kwa shuga.

Insulin iyenera kuperekedwa kwa theka la ola musanadye chakudya kapena kuwunikira pang'ono pamatumbo. Njira yothetsera vutoli amakonzedwa kale kutentha kwa chipinda. Monotherapy imakhudzana ndi jakisoni wofikira katatu pa tsiku (mwapadera, kuchulukitsa kumachulukitsa mpaka 6).

Ngati mlingo wa tsiku ndi tsiku umaposa 0,6 IU / kg, umagawidwa pazidutswa zingapo, jakisoni amaikidwa m'malo osiyanasiyana a thupi - minyewa ya brachial yakuda, khomo lakumbuyo lakumaso. Pofuna kuti musakhale ndi lipodystrophy, malo omwe jakisoni amasinthasintha. Singano yatsopano imagwiritsidwa ntchito jekeseni iliyonse. Zokhudza kayendetsedwe ka IM ndi IV, zimachitika kokha kuchipatala komwe ogwira ntchito azaumoyo amachita.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Odwala omwe apezeka ndi matenda a shuga panthawi ya kukonzekera, mimbulu yotsatira iyenera kuwunika kuchuluka kwa shuga m'magazi, chifukwa mungafunike kusintha mankhwalawa.

Kuyamwitsa kumaloledwa kuphatikiza ndi kugwiritsa ntchito insulin, ngati mkhalidwe wa mwana ukhala wokhutiritsa, palibe m'mimba wokhumudwa. Mlingowo umasinthidwanso malinga ndi kuwerenga kwa shuga.

Gensulin Overdose

Kugwiritsa ntchito insulini yambiri kumabweretsa hypoglycemia. Kuchepa pang'ono kwa matenda kumatha mwa kutenga shuga, kudya zakudya zamafuta ambiri. Ndikulimbikitsidwa kuti anthu nthawi zonse amakhala ndi chakudya chokoma ndi zakumwa ndi iwo.

Kuchepetsa kwambiri kungachititse kuti musamaganize bwino. Potere, yankho la iv dextrose limaperekedwa mwachangu kwa munthu. Kuphatikiza apo, glucagon imayendetsedwa iv kapena s / c. Munthu akabwera, ayenera kudya zakudya zokwanira zomanga thupi kuti asayambirenso kutero.

Kuchepetsa kwambiri kungachititse kuti musamaganize bwino.