Orlistat - mankhwala ochepetsa thupi: malangizo, mtengo, ndemanga

Orlistat (Orlistat, Orlistatum) - mankhwala a gulu lochepetsa lipid, okhala ndi zinthu zomwezi. Patsamba lamasitolo aku Russia, mutha kupeza mankhwala kuchokera kwa opanga awiri - Akrikhin (Poland) ndi Canon (Russia). Ndende ya yogwira thunthu muzochitika zonse ziwiri ndi 120 mg. Mankhwalawa amapezeka mu mawonekedwe a makapisozi okhala ndi ufa wowuma wa kristalo mkati. Zothandiza pazinthuzi ndi microcrystalline cellulose, talc, sodium starch glycolate, etc. Komanso m'mafakitore mungapeze njira yopanga ku UK, USA, Germany, China ndi India.

Mankhwala okhala ndi orlistat ngati chinthu chogwira amaperekedwanso pansi pa mayina ena ogulitsa: Orsoten ndi Orsoten Slim, Xenical, Alli, Orlimaks. Zinthu zamankhwala zoterezi zimatha kuonedwa kuti ndi ma syonyms kapena analogues.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chachikulu chogwiritsa ntchito mankhwalawa ndikufunika kuti muchepetse thupi, koma ayi. Madokotala amakonda kulimbikitsa mankhwalawa kwa odwala omwe ali ndi kunenepa kwambiri kwamitundu yosiyanasiyana. Zisonyezero zapadera za mankhwala ndi mphindi zotere:

• kulemera kwamphamvu kuposa 30 kg / m2,
• kunenepa kwambiri komwe kumawonetsedwa ndi makilogalamu oposa 27 kg / m2 ndi kupezeka kwa zinthu zoopsa: dyslipidemia, matenda a shuga, matenda oopsa,
• Kuchepetsa kuchepa kwa thupi pambuyo pa kunenepa kwambiri.

Njira ya kuchitapo kanthu ndi kuchita bwino

Orlistat idapangidwa koyamba mkati mwa 80s ndi a Swiss biochemists. Chuma chake chachikulu ndi kulepheretsa kwa m'mimba lipase (enzyme yomwe imaphwanya mafuta). Zotsatira zake, kugawanika kwamafuta kukhala mafuta acids ndi monoglycerides kumakhala kosatheka.

Mosiyana ndi zakudya zotsatsa zomwe zimafalitsidwa, mankhwalawa amagwira ntchito ndi lipid metabolism.

Popeza pakugwiritsa ntchito Orlistat, mafuta amasiya kulowa m'magazi, ndikupanga zoperewera, thupi limayamba kugwiritsa ntchito mafuta ake ngati magetsi. Malinga ndi kafukufuku wazachipatala zambiri, mankhwala achire amatha kupatsa 30% mafuta kuchokera ku chakudya.

Zofunika! Orlistat ndiye chinthu chokhacho chovomerezeka chovomerezeka ndi mankhwalawa kwa kunenepa kwambiri. Kamodzi m'maiko onse, amapezeka kokha mwakulembetsa. Lamulo lotero lidakalipobe ku Canada lero. Ku Russia, odwala nawonso sangagule zotsalazo. Mankhwala ena ali okonzeka kugulitsa mankhwala OTC, koma pokhapokha mulingo wa chinthu chomwe sichigwira 60 mg.

Monga bonasi, mankhwalawa amachepetsa cholesterol "yoyipa", imawongolera kuthamanga kwa magazi komanso kupewa matenda a shuga a mtundu wachiwiri. Madokotala amati chithandizo chokhazikika cha kuchuluka kwa thupi kudzera m'mankhwala omwe ali ndi orlistat chimakhala cholocha mwa munthu: akangotaya mafuta ambiri, kutsegula m'mimba kumawonedwa. Komabe, mphindi iyi siyikhudzana ndi thanzi lonse. Popeza chinthucho sichilowa m'magazi, zomwe zimapangitsa thupi kupewetsa thupi zimatha kupewedwa. Kagayidwe ka mankhwala amawona m'matumbo a matumbo. Imachoka kwathunthu patatha masiku angapo.

Chithandizo cha nthawi yayitali ndi Orlistat chimakuthandizani kuti muchepetse kulemera popanda kupitirira pazakudya - mpaka pafupifupi makilogalamu 8 m'miyezi itatu.

The World Organisation of Gastroenterologists amakhulupirira kuti mankhwala a orlistat ndi othandizira pochiza kunenepa kwambiri. Izi zikutsimikiziridwa ndi zotsatira za mayeso:

• Kwa miyezi itatu, odzipereka adatha kutaya mpaka 5% ya kulemera koyamba.
• Kuchepetsa kwakukulu kunawonedwa mwaoposa 70% ya odwala.

Komabe, pamaneti mungapeze malingaliro okwanira okhudza mankhwalawo ndi orlistat, ndikutsutsa kuyenera kwake. Ena amati mu theka la chaka ndizotheka kuchotsera kulemera kwa 10%, ndipo ngakhale pamenepa ngati zakudya zolimbitsa thupi zimawonedwa nthawi yomweyo ndikuchita zolimbitsa thupi kwambiri. Pali lingaliro lina - kumapeto kwa maphunzirowo, ma kilogalamu otayika amabwezeretsedwa. Madokotala amatsimikizira kutsimikizika kwa mawu awa, akuvomereza kuti asakane kudya kwamtundu womaliza kumapeto kwa kuwonda.

Malangizo ogwiritsira ntchito

Chosindikiza chimaphatikizidwa ndi phukusi lililonse la Orlistat. Kuyang'aniridwa ndendende kwamalingaliro omwe akuperekedwa ndi wopanga amachepetsa chiopsezo chokhala ndi vuto lodana ndi thupi ndikupeza zotsatira zabwino mokhudzana ndi kuchepa thupi. Ndikofunikanso kutsatira upangiri wa madokotala pakuthandizira kukonza bwino kwa chithandizo chambiri mopepuka kudzera mu mankhwalawa.

Ndondomeko yolandirira

Mankhwala adapangira pakamwa. Malamulo ogwiritsira ntchito ndi awa:

• Mlingo umodzi wa munthu wamkulu ndi 120 mg.
• Ndikulimbikitsidwa kutenga makapisozi atatu a 120 mg patsiku.
• Makapisozi amatengedwa ndi chakudya kapena ola limodzi mutamwa madzi ambiri.
• Kutafuna kapena kutsegula makapisozi ndizoletsedwa.

Zofunika! Mutha kudumpha kumwa ngati mankhwalawa ali ndi mafuta ochepa kwambiri, popeza chinthu chomwe chimayamba kugwira ntchito chimangoyambira pamaso pa ma enzyme m'mimba.

Ngati, pazifukwa zilizonse, chakudya chidatulutsidwa, simuyenera kumwa kapu ya mankhwala. Sikoyenera kuwonjezera kuchuluka kwa mlingo wotsatira, chifukwa izi sizingapangitse kuchuluka, koma zimapangitsa thanzi lanu kukhala labwino.

Kutalika kwabwino kwa maphunziro ochepetsa thupi ndi pafupifupi miyezi itatu (nthawi yifupi ndiyotheka kukhala kuwononga nthawi). Komabe, madokotala amalipira omwe akuchepetsa thupi kuti zotsatira zabwino zitheka ngati mankhwalawo atengedwa kwa miyezi 6 mpaka 12. Kutalika kwambiri kwa maphunzirowa ndi zaka 2.

Ngati kwa miyezi ingapo mankhwalawa sanaone kuti ndi othandiza, kuchepa thupi ndi mankhwalawo kumawoneka ngati kopanda tanthauzo.

Zotsatira zabwino zimatha kuphatikizidwa ndi kuphatikiza Orlistat ndi zakudya zama calorie ochepa. Kwa akazi, kudya kalori tsiku lililonse sikuyenera kupitirira 1300 kcal, kwa amuna - 1500 kcal. Ndi kuwonjezeka panthawi imodzimodzi zolimbitsa thupi, zizindikiro zingathe kukwezedwa ku 1,500 ndi 1,700, motsatana.

Zakudya zotsatirazi zizipezeka muzakudya:

• nsomba zamafuta ochepa ndi nyama (mpaka magalamu 150 tsiku lililonse),
• masamba omwe ali ndi index yotsika ya glycemic (udzu winawake, nkhaka, kabichi, tsabola wa belu, beets),
• chimanga (makamaka barele ndi burwheat),
• mafuta mkaka wowawasa wopanda mafuta ndi mkaka (ungagwiritsidwe ntchito mwangwiro kapena wogwiritsidwa ntchito pokonza zakudya),
• zipatso ndi zipatso zabwino,
• mkate wa chinangwa kapena ufa wosawola,
• zakumwa monga mawonekedwe a tiyi wosaphatikizika, compote (kuchokera ku zipatso zakomweko, shuga wopanda), madzi (osachepera malita awiri patsiku).

Mchere kwa nthawi yonse yochepetsa thupi uyenera kukhala wochepa. Kupewa chifukwa chofuna kuwonjezera luso, palinso mowa.

Zofunika! Orlistat imakhudza mayamwidwe a mavitamini osungunuka mafuta, chifukwa chake, pakakhala makonzedwe ake, ndikofunikira kugwiritsa ntchito maultivitamin ma vitamini A, D, E, etc. Mavitamini ayenera kumwedwa asanadye makapisozi, makamaka maola angapo.

Zotsatira zoyipa ndi zovuta

Makapisozi amathandizira kugwira ntchito kwa m'mimba. Popeza chithandizo chimachitika nthawi yayitali, kukhala bwino kumavutikanso. Zotsatira zoyipa kwambiri mukamamwa Orlistat ndi:

• kuchuluka kwa mpweya,
• chopondapo mafuta:
• kulephera kuwongolera chidwi chofuna kunyoza.

Ndiosavuta kufotokozera chitukuko chawo - vutoli limayamwa mafuta ambiri. Nthawi zambiri, mavuto ngati amenewa amadzidzidzikira okha thupi litayamba kuzolowera mankhwalawo. Komabe, pali milandu yovuta kwambiri. Chifukwa chake, kuyendera dokotala mwachangu kumafunikira zizindikiro zotsatirazi:

• mutu ndi kutentha thupi
• zilonda zapakhosi, chifuwa,
• kuzizira
• mphuno zakumwa ndi mphuno yakukola
• kuvunda kwa dzino, kutulutsa magaziamu,
• matenda a kwamkodzo thirakiti
• Zizindikiro za kuwonongeka kwa chiwindi: kusowa chilala, mkodzo wakuda, chikaso cha khungu ndi maso, nseru, kufooka, chopondera, kutopa kwambiri popanda chifukwa.

Kuyimbira mwachangu ma ambulansi kumafuna zizindikiro zomwe zingachitike chifukwa chakuchepa kwa mankhwala:

• zotupa zamkati, urticaria,
• kupuma movutikira
• kutupa kwa nkhope, mmero, milomo, kapena lilime.

M'malo mwake, zovuta zamagulu panthawi ya mankhwala ndi mankhwalawa ndizosowa kwambiri, chifukwa chake tinganene kuti mapindu ake amagwiritsidwa ntchito mopitilira chiwopsezo. Komabe, ngati zotsatira zoyipa zimawonedwa kwanthawi yayitali ndipo zimapangitsa kusasangalala kwakukulu, muyenera kufunsa dokotala. Mwina mankhwalawa amwa mankhwala olakwika kapena ndibwino kugwiritsa ntchito mankhwalawa.

Contraindication

Kuchepetsa thupi ndi mankhwala osavomerezeka sikuti:

• kuchuluka kwa zigawo zikuluzikulu,
• zaka mpaka 16,
• aakulu malabsorption syndrome (kulowetsedwa kwa chakudya m'mimba),
• nephrolithiasis,
• hyperoxaluria
• cholestasis (kusayenda kwa bile).

Amayi oyembekezera komanso oyamwitsa ayeneranso kupewa kumwa mankhwalawo, makamaka popanda mankhwala a dokotala. Izi zitha kukhala zowopsa kwa mwana!

Zochita Zamankhwala

Orlistat samangoyendetsa mayamwidwe a mavitamini - mkhalidwewo ndi wofanana ndi beta-carotene kuchokera kuzakudya zowonjezera. Kugwiritsa ntchito munthawi yomweyo kugwiritsa ntchito mankhwala a cyclosporine, sodium levothyroxine (hypothyroidism ingayambike), warfarin ndi acarbose osavomerezeka. Nthawi yomwe pakati pa kugwiritsa ntchito ndalamazi ndi Orlistat iyenera kukhala kuchokera 2 mpaka 4 maola.

Amayi omwe nthawi yomweyo amachepetsa thupi pakumwa kunenepa kwambiri ndikumwa mapiritsi oletsa kubereka ayenera kusamalira njira zina zakulera. Popeza mankhwalawa amayambitsa kutsekula m'mimba, kuchepa kwa kuchuluka kwa njira yakulera yamagazi m'magazi kungatheke.

Zofunika! Orlistat sichimachitika ndi mowa, zomwe zimapangitsa kuti asakakamize oletsedwa kugwiritsa ntchito omalizirawa (izi ndizofunikira kokha kuti munthu achepetse thupi kwambiri), ndipo sizikhudza chidwi cha anthu, chifukwa chomwe chimatha kugwiritsidwa ntchito poyendetsa galimoto.

Malo osungira

Malangizo ogwiritsira ntchito Orlistat akuti tikulimbikitsidwa kusunga makapisozi pamalo ozizira, owuma, ndipo, osafunikira, malo osafikirika ndi ana. Tsiku lotha ntchito litakhazikitsidwa phukusi, makapisozi sioyenera.

Mtengo wa mankhwalawa umatengera wopanga, kuchuluka kwa makapisozi mumapaketi ndi kuchuluka kwa zomwe zimagwira:

1. Orlistat-Akrikhin makapisozi 84 (120 mg) - kuchokera ku 1800 rubles.
2. Makapisozi a Orlistat-Canon 42 (120 mg) - kuchokera ku ma ruble 440.

Kugula ndalama muchipatala cha pa intaneti, monga momwe zimakhalira nthawi zonse, ndizotheka ndi mankhwala okha.

Mtengo wazinthu zomwe zimagwirizana (nthawi yomweyo zimatha kuonedwa ngati analogies ya Orlistat) zimatengera mlingo wa chinthucho ndi wopanga:

1. Xenical (Hoffman La Roche, Switzerland) ndi Mlingo wa 120 mg: makapisozi 21 - kuchokera ku ruble 800, 42 K. - kuchokera 2000 p., 84 K. - kuchokera 3300 p.
2. Orsoten (Krka, Slovenia) ndi Mlingo wa 120 mg: makapisozi 21 - kuchokera ku ma ruble 700, 42 K. - kuchokera ku 1400 rubles, 84 K. - kuchokera ku 2200 rubles.
3. Orsoten Slim (Krka-Rus, Russia) ndi mulingo wa 60 mg: makapisozi a 42 - kuchokera ma ruble 580.
4. Xenalten (Obolenskoye FP, Russia) ndi mlingo wa 120 mg: makapisozi 21 - ma ruble 715, 42 K. - 1160 rubles, 84 K. - 2100 rubles.
5. "Listata" (Izvarino Pharma, Russia) ndi Mlingo wa 120 mg: mapiritsi 30 - ma ruble 980, mapiritsi 60 - 1800 p., Mapiritsi 90 - 2400 p.
6. "Alli" (GlaxoSmithKline Consumer Healthcare L.P., USA) ndi mulingo wa 60 mg: makapisozi a 120 - kuchokera ma ruble 90.

Ndemanga ndi zotsatira za kuchepa thupi

Orlistat imathandizadi kuti muchepetse kunenepa, ndinganene kuchokera pazomwe ndakumana nazo. Koma osati zophweka. Choyamba, ndizovuta kugula mankhwala muchipatala cha pa intaneti chifukwa m'malo ochepa amapezeka ndikuwapereka popanda mankhwala. Kachiwiri, mphindi zomwe mankhwalawo amagulira zimakhala zodabwitsa. Kuchepetsa kulemera kwa mapulani oterowo sikotsika mtengo. Koma kuchitapo kanthu kumakhala kowopsa. M'masiku ochepa ovomerezeka, ndinali ku gehena! Ndinafunika kuyika gasket ku zovala zanga zamkati, chifukwa matumbo samayendetsedwa 100%. Mwa njira, sungani izi m'malingaliro ndikukonzekera kuyambitsa phwando la sabata. Vuto linanso ndi kuwira kosalekeza m'mimba. Inemwini anali wamanyazi ngakhale kupita kusitolo. Mwinanso, ena adaganiza kuti sindinadye sabata limodzi ... Komanso, sabata loyamba limalumikizidwa ndi ludzu komanso chizungulire. Kenako zonse zinayamba kukhala zabwinobwino. Ndamwa mankhwalawa kwa miyezi itatu. Adataya makilogalamu 6 kumapeto. Sindinadye kwambiri - ndimangokhalira makeke ndi sopo wokoma.

Monga momwe ndikudziwira, kukonzekera ndi orlistat ndi kocheperako kuposa ndi sibutramine yemweyo. Mukatha kugwiritsa ntchito, palibe kudalira, koma ndizotsimikizika. Izi zimatsimikiziridwa ndi zithunzi pa intaneti. Ine ndekha posachedwapa ndidayesa kuyesa kugwiritsa ntchito mankhwala ochepetsa mphamvu ya mankhwala, kenako ndidawerenga ndemanga pamabungwe ndikusintha malingaliro. Zachidziwikire kuti atsikanayo adatha kuchepetsa thupi, koma zidawonongeka bwanji! Kodi mungayitane bwanji malo abwino oti simungathe kutuluka mnyumbamo, chifukwa chimbudzi chiyenera kukhala chayandikira? Inemwini ndimakonda njira zosachepera - zakudya zopatsa thanzi, masewera, zopatsa thanzi.

Anastasia, wazaka 30

Pali mphekesera zosiyanasiyana zamapiritsi azakudya za Orlistat. Ine, monga munthu wosakwiya, ndidasankha kuyesa chilichonse m'thupi langa. Ndinafunika kuchepa thupi ndi 8-10 kilogalamu. Zakudya, zachidziwikire, zidagwa nthawi yomweyo, chifukwa kwa plumb yotere ndimangoyenera kudya. Chifukwa chake, komwe sindinaganizire za komwe ndingagule mankhwalawo, ndidayilamula kudzera pa intaneti. Mtengo inde, sizinasangalatse. Mukamvetsetsa kuti phukusi limodzi silikwanira maphunziro a miyezi itatu, mwanjira ina imakhala yomvera chisoni ndalama. Koma ine, mtengo wake udalipira.

Choyamba, mankhwalawa adandithandizira kuwongolera kudya zakudya zamafuta. Kukhala mchimbudzi tsiku lonse sakusaka, chifukwa chake ndimayenera kukana masangweji ndi batala ndi makeke amafuta nthawi yomweyo. Zotsatira zake zimadziwika - minus 11 kg mu 3 months. Izi ndizotsatira zabwino kwambiri zomwe ndakwanitsa mothandizidwa ndi mapiritsi. Ndikulimbikitsa.

Ndemanga za madotolo ndi akatswiri

Maria Gennadievna, katswiri-endocrinologist

Orlistat ndi imodzi mwamankhwala otetezeka kwambiri omwe angatengedwe kuchepetsa thupi. Komabe, ndikulondola kwambiri kuyamba kuzitenga mukakambirana ndi katswiri. Kukhala wathanzi ndikofunikira, popeza mankhwalawa angayambitse mavuto osaneneka. Ndikupangira makamaka kukhala osamala kwa anthu omwe akufuna kumwa mankhwala kuti athetse 1-5 kg. Ino si kuchuluka kwake kolemera komwe kumatha kudziwika kuti kotsutsa, chifukwa chake kugwiritsa ntchito Orlistat ndi ma fanifes ake amawonedwa kuti ndi osayenera. Ngati muwerenga mosamala malangizo, mutha kuwona zomwe zingagwiritse ntchito - kunenepa kwambiri komanso kukonza thupi pambuyo pakuchepa kwa mankhwala. Mwa njira, ngati kunenepa kwambiri kumayambitsidwa ndi chakudya chamagulu ambiri m'zakudya, mankhwalawa satha ntchito.

Ndipo mfundo ina yofunika: kuwonda msanga mukamamwa mankhwalawa sikuyembekezeredwa. Amachita zinthu mosamala, motero, amafunika ndalama zambiri.

Matvey Sergeevich, gastroenterologist

Orlistat ndi mankhwala apadera kuti muchepetse kunenepa kwambiri. Choyamba, izi zimachitika chifukwa cha makina ochitira.Mosiyana ndi zakudya zamagulu owonjezera, zomwe zadzaza masamba ogulitsa pa intaneti ndipo makamaka zimagwira ntchito pochotsa madzi m'thupi, mankhwalawa amagwira ntchito ndi lipid metabolism. Mwachilengedwe, munthawi imeneyi, kusintha kwa magwiridwe am'mimba ndikosapeweka, zomwe zimatsimikiziridwa ndikuwunika kambiri kwa Orlistat pa intaneti. Anthu amadandaula kuti kwa masiku angapo sasiya chimbudzi, chifukwa kuthekera kwa matumbo osakhudzika ndikokwanira. Monga dokotala, ndazindikira kuti mutha kuchepetsa chiopsezo cha "chodetsa" - ingosiya kudya zakudya zamafuta ambiri.

Mbali yachiwiri yosiyanayo ndi zotsalazo ndiye zotsimikizika zake. Ngakhale mutakhala kuti simutsatira zakudya ndipo osachulukitsa zolimbitsa thupi, maphunziro a miyezi itatu pamankhwala amathandizira kuti muchepetse thupi ndi ma kilogalamu ochepa.

Ndipo, pamapeto pake, chinthu chachikulu - mankhwala omwe amagwira ntchito amvomerezedwa, zomwe sizinganenedwe za sibutramine yomweyo. Kafukufuku wambiri watsimikizira kuti mapindu a orlistat amaposa zoopsa. Ngati mutsatira malangizowo ndipo osadzimvera chisoni, zotsatira zoyipa zitha kupewedwa kwathunthu.

Mankhwala

Mu gulu lake la mankhwala, orlistat imalepheretsa zam'mimba lipase, zomwe zikutanthauza kuti imalepheretsa kwakanthawi ntchito ya enzyme yapadera yomwe imapangidwa kuti igwetse mafuta kuchokera ku chakudya. Imagwira mu lumen m'mimba ndi m'mimba yaying'ono.

Zotsatira zake ndikuti mafuta osakwanira sangatengeke m'makoma a mucous, ndipo zopatsa mphamvu zochepa zimalowa m'thupi, zomwe zimabweretsa kuwonda. Orlistat kwenikweni simalowa m'magazi apakati, amapezeka m'magazi nthawi zambiri komanso pamiyeso yotsika kwambiri, yomwe singayambitse zotsatira zoyipa.

Zambiri zakuchipatala zimawonetsa kuti anthu omwe ali ndi kunenepa kwambiri komanso amtundu wa 2 shuga athandiza kwambiri pakulimbana ndi glycemic. Kuphatikiza apo, ndi makina a orlistat, zotsatirazi zidawonedwa:

• kuchepetsa kuchuluka kwa othandizira a hypoglycemic,
• kuchepa kwa ndende kukonzekera insulin,
• kuchepa kwa insulin kukana.

Kafukufuku wazaka 4 adawonetsa kuti mwa anthu onenepa omwe amakonda kukhala ndi matenda ashuga amtundu wa 2, chiopsezo cha kuyambitsidwa kwake chidachepa ndi 37%.

Kuchita kwa orlistat kumayamba patatha masiku 1-2 patatha mlingo woyamba, zomveka zomveka chifukwa cha mafuta omwe amapezeka mumalondowo. Kuchepetsa thupi kumayambira pakatha milungu iwiri ya kudya pafupipafupi komanso kupitilira miyezi 6 mpaka 12, ngakhale kwa anthu omwe sikuti amachepetsa thupi pazakudya zapadera.

Mankhwala sayambitsa kubwezeretsa kawirikawiri kulemera kwa mankhwala atasiya. Imasiya kutulutsa mphamvu pambuyo patha masiku 4-5 mutatenga kapisozi komaliza.

Zizindikiro ndi contraindication

1. Njira yayitali yothandizira anthu onenepa kwambiri omwe BMI yawo imaposa 30.
2. Chithandizo cha odwala omwe ali ndi BMI yoposa 28 komanso zinthu zoopsa zomwe zimayambitsa kunenepa kwambiri.
3. Chithandizo cha anthu omwe ali ndi matenda a shuga a 2 komanso kunenepa kwambiri omwe amamwa mankhwala a hypoglycemic komanso / kapena insulin.

Malo omwe orlistat yaletsedwa kapena kuletsedwa:

• Hypersensitivity pazinthu zilizonse zomwe zimapanga.
• Zaka mpaka zaka 12.
• Nthawi ya pakati ndi kuyamwa.
• Kuyamwa kwa michere yaying'ono yamatumbo.
• Mavuto ndi mapangidwe ndi ndulu ya bile, chifukwa imalowa mu duodenum yaying'ono.
• Ntchito munthawi yomweyo cyclosporine, warfarin ndi mankhwala ena.

Ngakhale zotsatira za kafukufuku wazinyama sizinawululire vuto loyenera la orlistat pa mwana wosabadwayo, amayi oyembekezera amaletsedwa kugwiritsa ntchito mankhwalawa. Kutheka kwa chinthu chomwe chikulowa mkaka wa m'mawere sichinakhazikitsidwe, chifukwa chake, panthawi ya chithandizo, mkaka wa m'mawere uyenera kumalizidwa.

Mankhwala osokoneza bongo ambiri komanso zoyipa

Kuyesa kunachitika ndikugwiritsa ntchito milingo yayikulu ya Orlistat kwa nthawi yayitali, zotsatira zoyipa sizinapezeke. Ngakhale bongo wambiri ukangodziwonekera, zizindikiro zake zimakhala zofanana ndi zovuta zomwe zimachitika, zomwe zimachedwa.

Nthawi zina mavuto amakuluka omwe amasinthika:

1. Kuchokera m'mimba thirakiti. Kupweteka kwam'mimba, kuphwasuka, kutsegula m'mimba, kupita pafupipafupi kupita kuchimbudzi. Zosasangalatsa kwambiri ndizakuti: kutulutsidwa kwamafuta osaphatikizika kuchokera ku rectum nthawi iliyonse, kutulutsa kwa mpweya ndi mpweya wochepa, fecal incontinence. Kuwonongeka kwa chingamu ndi mano nthawi zina kumadziwika.
2. Matenda opatsirana. Zowonekera: fuluwenza, matenda am'munsi komanso apamwamba am'mapapo, matenda amkodzo.
3. Kupenda. Kutsitsa kuchuluka kwa shuga m'magazi m'munsimu 3.5 mmol / L.
4. Kuchokera ku psyche ndi dongosolo lamanjenje. Mutu ndi nkhawa.
5. Kuchokera ku kubereka. Kuzungulira kosazungulira.

Kusokonezeka kochokera m'mimba ndi matumbo kumawonjezeka molingana ndi kuchuluka kwa mafuta m'zakudya. Amatha kuwongoleredwa ndi zakudya zamafuta ochepa.

Orlistat yoyambirira itatulutsidwa m'misika yamankhwala, zodandaula zotsatirazi zamavuto zinayamba kufika:

• magazi otupa
• kuyabwa ndi zotupa
• kuyika kwa oxalic acid amchere mu impso, komwe kunapangitsa kuti kulephera kwa impso,
• kapamba.

Kukula kwa zotsatirazi sizikudziwika, atha kukhala mu dongosolo limodzi kapena osakhudzana mwachindunji ndi mankhwalawo, koma wopanga amayenera kuwalembetsa iwo motsatira malangizo.

Malangizo apadera

Musanayambe chithandizo ndi Orlistat, ndikofunikira kuuza dokotala za mankhwala onse omwe amamwa mosalekeza. Zina mwa izo sizingafanane. Izi zikuphatikiza:

• Cyclosporin. Orlistat imachepetsa kukhazikika kwake m'magazi, zomwe zimayambitsa kuchepa kwa mphamvu ya immunosuppressive, yomwe ingasokoneze kwambiri thanzi. Ngati mukufunika kumwa mankhwalawa nthawi yomweyo, onetsetsani zomwe zili mu cyclosporine pogwiritsa ntchito mayeso a labotale.
• Mankhwala othandizira antiepileptic. Ndi makonzedwe awo omwewo, kukhumudwitsidwa nthawi zina kumawonedwa, ngakhale ubale wamphamvu pakati pawo sunawululidwe.
• Warfarin ndi zina zotero. Zomwe zili ndi mapuloteni amwazi, zomwe zimakhudzidwa ndi kuphatikizika kwake, nthawi zina zimatha kuchepa, zomwe nthawi zina zimasintha magawo a labotale.
• Mafuta mavitamini sungunuka (E, D ndi β-carotene). Kuyamwa kwawo kumachepa, komwe kumakhudzana mwachindunji ndi machitidwe a mankhwalawa. Ndikulimbikitsidwa kumwa mankhwalawa usiku kapena maola awiri mutatha kumwa kwa Orlistat yomaliza.

Njira ya mankhwalawa ndi mankhwalawa iyenera kuyimitsidwa ngati, pambuyo pa milungu 12 yogwiritsidwa ntchito, kulemera kwachepa ndi zosakwana 5% zoyamba. Mwa anthu omwe ali ndi matenda a shuga a 2, kuchepa thupi kumatha kuchepa.

Amayi omwe amamwa mapiritsi olembera piritsi amayenera kuchenjezedwa kuti panthawi ya chithandizo ndi Orlistat pakakhala pafupipafupi zimbudzi, chitetezo chowonjezera chimafunikira, popeza mphamvu ya othandizira mahomoni pazomwezi zimachepa.

Mtengo mumafakisi

Mtengo wa orlistat umatengera mlingo (60 ndi 120 mg) ndi kuyika kwa makapisozi (21, 42 ndi 84).

Mankhwalawa amayenera kutumizidwa ndi adokotala pokhapokha ngati mankhwalawa atatha kudya komanso kuchita masewera olimbitsa thupi sanapereke zotsatira zomwe akufuna. Anthu wamba opanda mavuto azaumoyo, salimbikitsidwa.

Momwe mungatengere Orlistat pakuchepetsa thupi: malangizo

Malinga ndi malangizo ogwiritsira ntchito, mapiritsi a Orlistat samagwira ntchito zomwe zatsala kale m'thupi la munthu. Mafuta omwe amabwera ndi chakudya panthawi yogwiritsira ntchito piritsi amatulutsidwa mosasinthika pakuyenda matumbo. Amayi ambiri amatenga Orlistat kuti achepetse thupi kuti mafuta asalowe m'mimba. Mankhwala amathandizanso kuchepetsa zakudya zopatsa mphamvu.

Kuti muchepetse kunenepa kwambiri, mawuwo akuwonetsa momwe mungagwiritsire ntchito bwino mankhwalawa kuti muchepetse kunenepa. Mlingo woyenera wa mankhwalawa ndi kapisozi imodzi mkati katatu / tsiku. Zakudya zowonjezera zimatengedwa mkati mwa ola limodzi mutatha kudya kapena nthawi yakudya. Kuti mukwaniritse bwino, kugwiritsa ntchito mankhwalawa kumalimbikitsidwa kwa miyezi itatu. Musanagule Orlistat, muyenera kufunsa dokotala kuti mupewe zomwe zingachitike.

Zotsatira zoyipa za mankhwalawa

Malinga ndikuwunika kochepa, kugwiritsa ntchito Orlistat mu kipimo komwe kumayambitsa sikubweretsa mavuto. Komabe, kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kapena kupitirira muyeso kumatha kuyambitsa zotsatirazi zathupi:

1. Mafuta amuchotsa kwa anus. Kuchitika pamene matumbo ambiri amasiya kuyamwa chakudya.
2. Tulutsani chopondapo. Pali kuphwanya kwamatumbo peristalsis.
3. Fecal kulephera. Kamvekedwe kakang'ono ka rectal kumachitika chifukwa cha kutayika kwa elasticity chifukwa chosagwirizana ndi mankhwalawa.
4. Zachisangalalo. Imachitika ndi chakudya chopatsa thanzi, kusowa kwamafuta osungunuka wamafuta, komanso kuchuluka kwa chakudya chosalowetsedwa cholowa m'matumbo am'munsi.

Kodi chimathandiza Orlistat ndi chiyani?

Malinga ndi a Doctor Desk Reference (2009), orlistat akuwonetsedwa pochiza kunenepa kwambiri, kuphatikiza Kuchepetsa ndi kusamalira thupi, kuphatikiza ndi zakudya zochepa zopatsa mphamvu. Orlistat imawonetsedwanso kuti muchepetse chiwopsezo chopezanso kulemera kwa thupi pambuyo kuchepa kwake koyamba. Orlistat imawonetsedwa kwa odwala onenepa kwambiri omwe amakhala ndi index ya ≥30 kg / m2 kapena ≥27 kg / m2 pamaso pazinthu zina zowopsa (matenda osokoneza bongo, matenda oopsa, matenda oopsa (dyslipidemia).

Imwani 120 mg pakumwa pa chakudya chachikulu chilichonse kapena pakatha ola limodzi mutatha kudya, nthawi zambiri osapitirira katatu / tsiku. Ngati chakudya chanu ndichoperewera, mutha kudumpha orlistat.

Zotsatira za pharmacological

Chithandizo chogwira mankhwalawa chimalepheretsa michere m'matumbo ndi m'mimba yomwe imaphwanya mafuta (lipases). Pankhaniyi, zimatha kukhala zosavuta kuti mafotokozedwe osavuta amafuta akhale amafuta acids ndi monoglycerides, ndipo samamwa, koma amuchotsa pamimba osasinthika. Zomwe zimapanga kugaya mafuta sizimayikidwa m'magazi mukamamwa Orlistat, ndiye kuti, thupi limapanga chosowa cha calorie, chifukwa chomwe chimayamba kutaya chake, chomwe chimayikidwa mu mawonekedwe a minofu yambiri ya adipose.

Mlingo wovomerezeka wa mankhwalawa umawonetsa ntchito yake, osapereka mphamvu yonse yamoyo. Mankhwala othandizira a Orlistat amalepheretsa chimbudzi cha mafuta pafupifupi 30%. Malinga ndi kafukufuku, mankhwalawa samakhudza mawonekedwe a bile, kuthamanga kwa chakudya cha m'mimba kapena kuchuluka kwa madzi a m'mimba. Zokhudza kuchuluka kwa mankhwalawa pamwamba pa achire sizinachitike. Kuyang'anira kwa Orlistat kwa nthawi yayitali (masabata atatu kapena kupitilira apo) kunakhudza pang'ono pazinthu zina za mthupi (magnesium, calcium, zinki, mkuwa, chitsulo, phosphorous).

Malinga ndi zomwe wapezeka, patatha maola 24-48 atatha kulandira chithandizo ndi mankhwala omwe amapondera, mafuta omwe amapezeka amawonjezeka. Pambuyo pa kufooka kwa Orlistat, mafutowo mu chopondapo amachepetsa kukhala wamba pakatha masiku awiri ndi atatu.

Ndemanga za kuchepetsa kunenepa

Tizindikire kuti ndemanga zakuchepera azimayi pamankhwala Orlistat, ndizabwino. Iwo ati atamwa mankhwalawa, adatha kutaya pafupifupi 10 kg m'miyezi isanu ndi umodzi. Pambuyo pake, kulemera kumayamba kuchoka osati mwachangu kwambiri, komabe kumatsika.

Komabe, sikuti aliyense amakhutira ndi zomwe Orlistat akuchita. Amayi ena akuti kumwa mankhwalawa sikunawabweretsere vuto lililonse, kunayambitsanso kukulira kwa mavuto oyambitsidwa ndi m'mimba. Monga lamulo, azimayi olemera makilogalamu oposa 100 amasiya mauthenga otere. Nthawi yomweyo, amalemba kuti samapatula zakudya zotsekemera komanso zosakhudzana ndi zakudya, ndipo samalongosola zina za thanzi ndi moyo.

Monga mukudziwa, mapaundi owonjezera amadziunjikira pazaka zambiri ndipo kuwachotsa mwachangu sikophweka. Njira yochepetsera thupi imafunikira njira yophatikizira kwa nthawi yayitali. Ndikofunika kulimbana kwambiri ndi kunenepa moyang'aniridwa ndi katswiri, chifukwa izi zimakupatsani mwayi woti musankhe pulogalamu yoyenera ndikupeza zotsatira zotsimikizika.

Zofanana muzochitika zamagulu:

• Allie
• Xenalten
• Kuwala kwa Xenalten,
• Xenalten Slim,
• Xenical
• Mndandanda
• Mndandanda wa Miniata,
• Orlimax
• Kuwala kwa Orlimax,
• Orlistat Canon
• Orsoten
• Orsotin Slim.

Chidwi: kugwiritsa ntchito ma fanizo kuyenera kuvomerezana ndi adokotala.

Mtengo wamba wa Orlistat m'mafakisi (Moscow) ndi ma ruble 1,500.

Kugula?

Mutha kugula Orlistat ku Moscow ku pharmacy kapena kupanga oda ndi makalata. Ndi wotsika mtengo kugula mankhwalawo nthawi yonseyi. Mankhwalawa ndi otsika mtengo okhala ndi makapisozi ambiri pabokosi lamakhadi. Mutha kugula mankhwala kuti muchepetse kulemera kwamankhwala muma intaneti:

• Liquoria (Moscow, Saltykovskaya st., 7, nyumba 1).
• Dokotala wanga (Novosibirsk, 1 Demakova St.).
• Glazkovskaya (Irkutsk, Tereshkova St., 15a).
• Kiy Avia No. 1 (Kiev, 56 Mezhigorskaya St.).
• Aksimed (Odessa, 28 Rishelievskaya St.).
• Falbi-Kharkov Pharmacy No 15 (Kharkiv, Valentinovskaya St., 29b).

Kodi Orlistat imawononga ndalama zingati? Mtengo muma Russian pharmacies umatengera kuchuluka kwa makapisozi mu phukusi ndi kwa wopanga. Mtengo wapakati wa mankhwala ku Russia ndi ma ruble 1300 a ma PC 21. 120 mg Mankhwala ofanana ndi a ku Switzerland ofanana amatenga ma ruble 2300 a phukusi lofanana. Ku Ukraine, mankhwalawa amagulitsidwa pamtengo wa 500 hryvnia kwa 21 ma PC. Ku Belarus - kuchokera 40 bel. opaka kwa ma CD omwewo.

Ma Analogs a Orlistat

Chingalowe m'malo ndi Orlistat ndi chiyani? Mitu yodziwika ya mankhwalawa imakhala ndi zinthu zomwezo, koma ndizosiyana pazinthu zothandizira. Msika wamakono wamankhwala umapereka mankhwala osiyanasiyana ofanana ndi Orlistat:

1. Xenical. Mankhwala a ku Switzerland omwe ali ndi yogwira mankhwala orlistat. amathandizanso pakhale nthawi yayitali odwala omwe ali ndi kunenepa kwambiri. Amagwiritsidwa ntchito ndi zakudya zamagulu a hypocaloric. Sitikulimbikitsidwa kuti mutenge pakati pa nthawi yomwe muli ndi pakati, chifukwa palibe chidziwitso chachipatala pa chitetezo chake.
2. Orsoten. Mankhwala ochepetsa thupi amatanthauza mankhwalawa ochepetsa lipid. Orsoten amalumikizana ndi pancreatic ndi gastric lipases mu lumen ya chimbudzi, motero ma enzymes satenga nawo gawo pakuwonongeka kwamafuta.
3. Mndandanda. Amagwiritsidwa ntchito kunenepa. Chisamaliro chapadera chiyenera kutengedwa panthawi yomwe ali ndi pakati komanso mkaka wa m'mawere. Ngati bongo, mafuta okumbika, peremptory chilimbikitso chofuna kunyoza, komanso kupweteka kwam'mimba kumachitika. Njira yofunsira ikufanana ndi kutenga Orlistat.
4. Allie. Lipase inhibitor. Ndi kugwiritsa ntchito mwadongosolo, amachepetsa thupi, makamaka osagwidwa m'mimba. Ilibe mphamvu yothandizanso. Osavomerezeka pa mimba. Ngati bongo, nkhawa kuchepa kwa chidwi, kusakhazikika kwa thupi, komanso kukula kwa matumbo pafupipafupi nthawi zina kumawonedwa.
5. Xenalten. Makapisozi ndi yogwira mankhwala orlistat. Xenalten amagwiritsidwa ntchito pochiza kunenepa kwambiri. Amasonyezedwa matenda a shuga, dyslipidemia, ochepa matenda oopsa. Pogwiritsa ntchito nthawi yomweyo ndi cyclosporine, kuchuluka kwa otsirizira mu plasma kumachepa.