Hainemox (Hinemox) > Chithandizo ndi kupewa

Mapiritsi, okhala ndi utoto wofiirira wofiirira, amakhala otayirira, biconvex, ndi notch, pa nthawi yopuma - misa kuyambira yoyera mpaka kuwala wachikasu yofiyira mitundu.

1 tabu
moxifloxacin hydrochloride	436.3 mg
zomwe zimagwirizana ndi zomwe zili moxifloxacin	400 mg

Othandizira: chimanga wowuma - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, talc - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl - 20 mg, anrogenrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg ma cellcose a microcrystalline - 130.7 mg.

Mapangidwe a Shell: Opadry yoyera 85G58997 Makc-Colorcon (polyvinyl mowa, titanium dioxide, talc, macrogol 3000, lecithin (soy) - 17.32 mg, okusayidi wachitsulo - 0,68 mg.

Ma PC 5. - matuza (1) - mapaketi a makatoni.
7 ma PC - matuza (1) - mapaketi a makatoni.
Ma PC 10 - matuza (1) - mapaketi a makatoni.
Ma PC 5. - matuza (2) - mapaketi a makatoni.
7 ma PC - matuza (2) - mapaketi a makatoni.
Ma PC 10 - matuza (2) - mapaketi a makatoni.
Ma PC 5. - matuza (10) - mapaketi a makatoni.
7 ma PC - matuza (10) - mapaketi a makatoni.
Ma PC 10 - matuza (10) - mapaketi a makatoni.
Ma PC 100 - matumba (1) (a zipatala) - zitini za pulasitiki.
Ma 500 ma PC - matumba (1) (a zipatala) - zitini za pulasitiki.
Ma PC 1000 - matumba (1) (a zipatala) - zitini za pulasitiki.

Zotsatira za pharmacological

Wothandizira antimicrobial kuchokera pagulu la fluoroquinolones, amachita bactericidal. Imagwira pakulimbana ndi tizilombo tating'onoting'ono tambiri ta gramu-gramu komanso gram-negative, anaerobic, acid osagwira komanso mabacteria atypical: Mycoplasma spp., Chlamydia spp., Legionella spp. Kugwiritsa ntchito polimbana ndi mabakiteriya okhala ndi beta-lactams ndi macrolides. Imagwira pakulimbana ndi tizilombo tosiyanasiyana tambiri tating'onoting'ono: gram-positive - Staphylococcus aureus (kuphatikiza zingwe zomwe sizimvera mwachangu methicillin), Streptococcus pneumoniae (kuphatikiza tizilombo ta penicillin ndi macrolides), Streptococcus pyogene (gulu A), gram-negative - kuphatikizapo hememilus ndi mitundu yopanda-beta-lactamase yopangira), Haemophilus parainfluenzae, Klebsiella pneumoniae, Moraxella catarrhalis (kuphatikiza mitundu yopanda-beta komanso ya beta-lactamase yopanga), Escherichia coli, Enterobacter cloacae, atypical Chlamydia pneumonia. Malinga ndi kafukufuku wa in vitro, ngakhale tizilombo tating'onoting'ono taikidwa pansipa timazindikira moxifloxacin, komabe, chitetezo chake komanso magwiridwe ake othandizira matenda sizinakhazikitsidwe. zamoyo galamu HIV: Streptococcus milleri, Streptococcus mitior, Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus cohnii, Staphylococcus epidermidis (kuphatikizapo tizilombo ta, methicillin tcheru), Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, Staphylococcus simulans, Corynebacterium diphtheriae. Zamoyo zopanda gramu: Bordetella pertussis, Klebsiella oxytoca, Enterobacter aerogene, Enterobacter agglomerans, Enterobacter Intermedius, Enterobacter sakazaki, Proteus mirabilis, Proteus vulgaris, Morganella morganii, Providencia rettgeri, Providencia stuartii. Anaerobic tizilombo: Bacteroides distasonis, Bacteroides eggerthii, Bacteroides fragilis, Bacteroides ovatus, Bacteroides thetaiotaornicron, Bacteroides uniformis, Fusobacterium spp, Porphyromonas spp, Porphyromonas anaerobius, Porphyromonas asaccharolyticus, Porphyromonas Magnus, Prevotella spp, Propionibacterium spp, Clostridium perfringens, Clostridium .... ramosum. Tizilombo tating'onoting'ono: Legionella pneumophila, Caxiella burnettii.

Ma blocks topoisomerases II ndi IV, ma enzymes omwe amawongolera zinthu zapamwamba za DNA, ndipo amathandizira kubwereza, kukonza, ndikulemba kwa DNA. Mphamvu ya moxifloxacin zimatengera kukhazikika kwake m'magazi ndi zimakhala. Zozungulira zochepa za bactericidal pafupifupi sizimasiyana ndi zochepa zoletsa.

Kukana njira zopangira, kupangira penicillin, cephalosporins, aminoglycosides, macrolides ndi tetracyclines, sizimakhudzana ndi antibacterial zochita za moxifloxacin. Palibe kukana pakati pa moxifloxacin ndi mankhwalawa. Njira yolimbirana yolimbana ndi plasmid -edi yolankhulirana siinawonedwe. Zowonjezera zonse zakusagwirizana ndizochepa. Kafukufuku wa in vitro awonetsa kuti kukana kwa moxifloxacin kumakula pang'onopang'ono chifukwa cha kusinthana kotsatizana. Kudziwitsidwa pafupipafupi kwa tizilombo tosiyanasiyana tokhala ndi moxifloxacin mozama mozama, zolembera za BMD zimangokulira pang'ono. Kutsutsa kwamtanda kumawonedwa pakati pa mankhwala ochokera ku gulu la fluoroquinolone. Komabe, tizilombo tating'onoting'ono ta gramu-ana ndi anaerobic omwe amalimbana ndi fluoroquinolones ena amamvera moxifloxacin.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, moxifloxacin imagwira mwachangu komanso pafupifupi kwathunthu. Pambuyo pa limodzi mlingo wa moxifloxacin pa mlingo wa 400 mg C max m'mwazi zimatheka mkati mwa maola 0.5-4 ndipo ndi 3.1 mg / L.

Pambuyo pa kulowetsedwa kamodzi pa mlingo wa 400 mg wa 1 h, C max imafika kumapeto kwa kulowetsedwa ndipo ndi 4.1 mg / l, yomwe ikufanana ndi kuwonjezeka kwa pafupifupi 26% poyerekeza ndi mtengo wa chizindikirocho mukamamwa. Ndi ma infusions angapo a IV pamiyeso ya 400 mg kwa 1 ora, C max imasiyanasiyana pamakina kuyambira 4.1 mg / l mpaka 5.9 mg / l. Avereji ya C ss ya 4.4 mg / L imafika kumapeto kwa kulowetsedwa.

Mtheradi bioavailability pafupifupi 91%.

Pharmacokinetics ya moxifloxacin atamwa limodzi mu 50 mg mpaka 1200 mg, komanso mlingo wa 600 mg / tsiku kwa masiku 10, ndi liniya.

Dera lolingana limafikiridwa pakatha masiku atatu.

Kumangiriza kumapuloteni amwazi (makamaka albin) pafupifupi 45%.

Moxifloxacin imagawiridwa mwachangu mu ziwalo ndi minofu. V d ndi pafupifupi 2 l / kg.

Kuzungulira kwa moxifloxacin, ochulukirapo kwa omwe amapezeka m'madzi a m'magazi, kumapangidwa minofu ya m'mapapo (kuphatikizapo alveolar macrophages), mucous membrane wa bronchi, mu sinuses, mu minofu yofewa, khungu ndi subcutaneous zida, maziko a kutupa. Mu madzi akumwa ndi malovu, mankhwalawa amatsimikiza mawonekedwe omasuka, osakhala ndi mapuloteni, pamsika wambiri kuposa plasma. Kuphatikiza apo, kuchuluka kwazomwe zimagwira ntchito zimatsimikizika mu ziwalo zam'mimba komanso zotumphukira zamkati, komanso mu ziwalo za akazi.

Biotransformed kuti yogwira sodium mankhwala ndi glucuronides. Moxifloxacin saumbidwa ndi microsomal chiwindi michere ya cytochrome P450 system.

Pambuyo popyola gawo lachiwiri la biotransfform, moxifloxacin imachotsedwa m'thupi ndi impso komanso matumbo, osasinthika komanso mawonekedwe osakanikirana a sulfo mankhwala ndi glucuronides.

Amayikamo mkodzo, komanso ndowe, zonse zosasinthika komanso ma metabolites osagwira. Ndi gawo limodzi la 400 mg, pafupifupi 19% imachotsedwa mu mkodzo, pafupifupi 25% yokhala ndi ndowe. T 1/2 ndi pafupifupi maola 12. Nthawi zonse chilolezo chomaliza pambuyo pa chithandizo cha 400 mg chimachokera 179 ml / mphindi mpaka 246 ml / min.

Zowonetsa ndi Mlingo:

chibayo chopezeka pagulu, kuphatikizapo chibayo chomwe chimapezeka m'deralo, zomwe zimapangitsa kuti tizilombo tosiyanasiyana tambiri tomwe timayambitsa tizilombo tating'onoting'ono tomwe timagwirizana ndi antibacterial mankhwala *,

pachimake bakiteriya sinusitis,

matenda osavuta komanso ovuta a pakhungu ndi minofu yofewa (kuphatikizapo phazi la matenda ashuga),

zovuta zamkati zam'mimba, kuphatikizapo matenda a polymicrobial, kuphatikizapo makasitomala amkati,

zovuta zotupa matenda a m'chiuno ziwalo (kuphatikizapo salpingitis ndi endometritis).

Tengani hinemok mkati, kumeza lonse, osafuna kutafuna, kumwa madzi ambiri, makamaka mukatha kudya. Musapitirire mlingo woyenera.

Mlingo wa kulowetsedwa maola 24 aliwonse (1 nthawi patsiku), mg Kutalika kwa mankhwalawa, masiku omwe anthu amapeza chibayo 4007-14 Kuchulukitsa kwa matenda a bronchitis 4005-10 pachimake bakiteriya osokoneza bongo 4007 Matenda osapweteka a pakhungu ndi zida zopanga 4007 - 219

Musapitirire nthawi yolimbikitsidwa.

Kusintha kwa muyezo wachiperekedwe kumafunikira: odwala okalamba, odwala omwe ali ndi vuto la chiwindi (kalasi A, B pa kuchuluka kwa Mwana-Pugh), odwala omwe ali ndi vuto laimpso (kuphatikizapo kuperewera kwambiri kwa aimpso ndi creatinine Cl ≤30 ml / min / 1.73 m2, komanso omwe ali ndi hemodialysis wopitiliza nthawi yayitali komanso amakhala kunja, odwala amitundu yosiyanasiyana.

Zotsatira zoyipa

Thupi lawo siligwirizana ndi zigawo za Heinemox: zotupa, kuyabwa, urticaria.

Kuchokera pamtima dongosolo: tachycardia, zotumphukira edema, magazi ochulukirapo, palpitations, kupweteka pachifuwa.

Kuchokera pamimba: kupweteka kwam'mimba, nseru, kutsegula m'mimba, kusanza, kugona, kutsekemera, kudzimbidwa, kuwonjezeka kwa hepatic transaminases, kulawa kupindika.

Pa gawo la magawo a labotale: kuchepa kwa prothrombin, kuchuluka kwa ntchito za amylase.

Kuchokera ku hemopoietic dongosolo: leukopenia, eosinophilia, thrombocytosis, thrombocytopenia, kuchepa magazi.

Kuchokera kumbali ya chapakati mantha dongosolo ndi zotumphukira mantha dongosolo: chizungulire, kusowa tulo, mantha, nkhawa, asthenia, mutu, kugwedezeka, paresthesia, kupweteka kwa mwendo, kukokana, chisokonezo, kukhumudwa.

Kuchokera ku minculoskeletal system: kupweteka kumbuyo, arthralgia, myalgia.

Kuchokera pakubala: vagidi candidiasis, vaginitis.

Mafunso, mayankho, ndemanga zamankhwala Heinemoks

Zomwe zimaperekedwa zimakonzekera akatswiri azamankhwala komanso zamankhwala. Chidziwitso chokwanira chokhudza mankhwalawa chili m'malangizo omwe amaphatikizidwa ndi zomwe amapanga ndi wopanga. Palibe chidziwitso chomwe chatumizidwa patsamba lino kapena tsamba lililonse la tsamba lathu chomwe chingagwire ntchito ngati cholowa m'malo mwapadera kwa katswiri.

Gulu la Nosological (ICD-10)

Mapiritsi okhala ndi mafilimu	1 tabu.
ntchito:
moxifloxacin hydrochloride	436.3 mg
(Imafanana ndi moxifloxacin - 400 mg)
zokopa: wowuma chimanga - 52 mg, sodium lauryl sulfate - 7.5 mg, kuyeretsa talc - 15 mg, magnesium stearate - 6.5 mg, carboxymethyl wowuma sodium - 20 mg, anhydrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg, MCC - 130.7 mg
filimu sheath: Opadry zoyera (85G58977) Pangani makongoletsedwe (mowa wa polyvinyl, titanium dioxide, talc, macrogol 3000, lecithin (soya) - 17.32 mg, okusayidi wachitsulo - 0,68 mg

Kupanga ndi mawonekedwe a kumasulidwa

Mapiritsi - 1 piritsi:

Mphamvu yogwira: moxifloxacin hydrochloride 436.3 mg, womwe umagwirizana ndi zomwe moxifloxacin 400 mg.
Omwe akalandira: wowuma wa chimanga - 52 mg, lactose monohydrate - 68 mg, sodium lauryl sulfate - 7.5 mg, woyeretsedwa wa talc - 15 mg, magnesium stearate - 6.5 mg, sodium carboxymethyl wowuma - 20 mg, anrogenrous colloidal silicon dioxide - 3.5 mg, croscarmellose sodium - 6.5 mg, ma cellcose a microcrystalline - 130.7 mg.
Mapangidwe a Shell: Opadry yoyera 85G58997 Makc-Colorcon (polyvinyl mowa, titanium dioxide, talc, macrogol 3000, lecithin (soy) - 17.32 mg, okusayidi wachitsulo - 0,68 mg.

Ma PC 5. - matuza (1) - mapaketi a makatoni.

Mapiritsi, okhala ndi utoto wofiirira wofiirira, amakhala otayirira, biconvex, ndi notch, pa nthawi yopuma - misa kuyambira yoyera mpaka kuwala wachikasu yofiyira mitundu.

Pambuyo pakukonzekera pakamwa, moxifloxacin imagwira mwachangu komanso pafupifupi kwathunthu. Pambuyo pa limodzi mlingo wa moxifloxacin pa 400 mg C _max m'magazi amafikiridwa mkati mwa maola 0.5-4 ndipo ndi 3.1 mg / l.

Pambuyo kulowetsedwa kamodzi pa mlingo wa 400 mg wa 1 h C _max akwaniritsidwa kumapeto kwa kulowetsedwa ndipo ndi 4.1 mg / l, omwe amafanana ndi kuwonjezeka kwa pafupifupi 26% poyerekeza ndi mtengo wa chizindikirocho mukamamwa. Ndi ma infusions angapo a IV pa mlingo wa 400 mg wamuyaya 1 h C _max zimasiyana pamitundu yosiyanasiyana kuchoka pa 4.1 mg / l mpaka 5.9 mg / l. Css wamba ya 4.4 mg / L imafika kumapeto kwa kulowetsedwa.

Mtheradi bioavailability pafupifupi 91%.

Pharmacokinetics ya moxifloxacin atamwa limodzi mu 50 mg mpaka 1200 mg, komanso mlingo wa 600 mg / tsiku kwa masiku 10, ndi liniya.

Dera lolingana limafikiridwa pakatha masiku atatu.

Kumangiriza kumapuloteni amwazi (makamaka albin) pafupifupi 45%.

Moxifloxacin imagawiridwa mwachangu mu ziwalo ndi minofu. Vd pafupifupi 2 L / kg.

Biotransformed kuti yogwira sodium mankhwala ndi glucuronides. Moxifloxacin saumbidwa ndi microsomal chiwindi michere ya cytochrome P450 system.

Pambuyo popyola gawo lachiwiri la biotransfform, moxifloxacin imachotsedwa m'thupi ndi impso komanso matumbo, osasinthika komanso mawonekedwe osakanikirana a sulfo mankhwala ndi glucuronides.

Amayikamo mkodzo, komanso ndowe, zonse zosasinthika komanso ma metabolites osagwira. Ndi gawo limodzi la 400 mg, pafupifupi 19% imachotsedwa mu mkodzo, pafupifupi 25% yokhala ndi ndowe. T1 / 2 ndi pafupifupi maola 12. Nthawi zonse chilolezo chitakhala kuti chinaperekedwa pa 400 mg kuchokera pa 179 ml / mphindi mpaka 246 ml / mphindi.

Mankhwala antibacterial a gulu la fluoroquinolone.

Mlingo wa Heinemox

Mkati, 400 mg 1 nthawi / tsiku. Njira ya mankhwala kukokomeza matenda osakhazikika - masiku 5, chibayo - anthu masiku 10, pachimake sinusitis, matenda a pakhungu ndi zimakhala zofewa - masiku 7.

Moxifloxacin ndi mankhwala mosamala vuto la khunyu (kuphatikizapo mbiri), khunyu, chiwindi, kulephera kwa nthawi ya QT.

Mankhwalawa ndi fluoroquinolones, kutupa ndi kupindika kwa tendon kumatha kukula, makamaka kwa odwala okalamba komanso odwala omwe akulandira nthawi yomweyo corticosteroids. Pazizindikiro zoyambirira za kupweteka kapena kutupa kwa tendon, odwala ayenera kusiya kulandira chithandizo ndikuwamasula miyendo yomwe yakhudzidwa ndi katunduyo.

Mankhwala

Moxifloxacin ndi mankhwala osiyanasiyana a bactericidal antibacterial of the fluoroquinolone mndandanda, 8-methoxy fluoroquinolone. Imalepheretsa topoisomerase II ndi topoisomerase IV, imasokoneza kuphatikiza kwakukulu ndi kuphatikiza kwa kupuma kwa DNA, imalepheretsa kaphatikizidwe ka DNA, imayambitsa kusintha kwakukuru kwa ma cytoplasm, khoma la maselo ndi ma membrane amomwe amathandizira tinthu tosiyanasiyana.Ma bactericidal ocheperako okhala moxifloxacin nthawi zambiri amatha kuyerekeza ndi ma inhibitory concentrations (MICs).

Njira zomwe zimatsogolera pakupanga kukana kwa penicillin, cephalosporins, aminoglycosides, macrolides ndi ma tetracyclines saphwanya antibacterial zochita za moxifloxacin. Palibe kutsutsana kwapakati pa magulu awa a antibacterial mankhwala ndi moxifloxacin. Pakadali pano, sipanakhalepo zochitika za kukana kwa plasmid. Pafupipafupi kukula kwa kukana ndikochepa kwambiri (10 -7-10 -10). Kukana moxifloxacin kumayamba pang'onopang'ono kudutsa masinthidwe angapo. Kuchulukanso kwa moxifloxacin pama cellorganic oyenda pansipa MIC amaphatikizidwa ndi kuwonjezeka pang'ono chabe kwa MIC. Milandu yotsutsana ndi quinolones imadziwika. Komabe, tizilombo tating'onoting'ono tokhala ndi gramu komanso anaerobic osagwirizana ndi ma quinolones ena amakhala tcheru ndi moxifloxacin.

Moxifloxacin mu vitro yogwira polimbana ndi tizilombo tating'onoting'ono ta gramu-gramu komanso gramu-zabwino, anaerobes, mabakiteriya osagwira asidi komanso mabakiteriya atypical monga Mycoplasma spp., Chlamydia spp., Legionella spp.komanso mabakiteriya osagonjetsedwa ndi mankhwala a beta-lactam ndi macrolide.

Kuwonekera kwa antibacterial zochita za moxifloxacin kumaphatikizanso tizilombo totsatirazi.

Zabwino zokha: Gardnerella vaginalis, Streptococcus pneumoniae * (kuphatikiza tizilombo ta penicillin ndi mabakiteriya okhala ndi mitundu yambiri yoletsa antibayotiki), Streptococcus pyogene (gulu A) *, gulu Streptococcus milleri (S. anginosus *, S. constellatus *, S. intermedius *), gulu Streptococcus viridans (S. viridans, S. mutans, S. mitis, S. sanguinis, S. salivarius, S. thermophilus, S. constellatus), Streptococcus agalactiae, Streptococcus dysgalactiae, Staphylococcus aureus (kuphatikiza miticillin yovuta kumva) *, coagulase-negative staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans), kuphatikiza mitsempha yokhala ndi methicillin.

Zoyipa: Haemophilus influenzae (kuphatikiza zingwe zopangidwa ndi beta-lactamases) *, Haemophilus parainfluenzae *, Moraxella catarrhalis (kuphatikiza zingwe zopangidwa ndi beta-lactamases) *, Bordetella pertussis, Legionella pneumophila, Acinetobacter baumannii, Proteus vulgaris.

Anaerobes: Fusobacterium spp., Porphyromonas spp., Prevotella spp., Propionibacterium spp.

Zosatheka: Chlamydia pneumoniae *, Chlamydia trachomatis *, Mycoplasma pneumoniae *, Mycoplasma hominis, Mycoplasma genitalium, Legionella pneumophila *, Coxiella burnetii.

Zabwino zokha: Enterococcus faecalis * (imangoyang'ana za vancomycin ndi glamicin) Enterococcus avium *, Enterococcus faecium *.

Zoyipa: Escherichia coli *, Klebsiella pneumoniae *, Klebsiella oxytoca, Citrobacter freundii *, Enterobacter spp. (E. aerogenes, E. intermedius, E. sakazakii), Enterobacter cloacae *, Pantoea agglomerans, Pseudomonas fluorescens, Burkholderia cepacia, Stenotrophomonas maltophilia, Proteus mirabilis *, Morganella morganii, Neisseria gonorrhoeae * Prov. (P. rettgeri, P. stuartii).

Anaerobes: Bacteroides spp. (B. fragilis *, B. distasonis *, B. thetaiotaomicron *, B. ovatus *, B. yunifolomu *, B. vulgaris *), Peptostreptococcus spp., Clostridium spp.

Zabwino zokha: Staphylococcus aureus (methicillin / ofloxacin zosagwira zovuta) **, coagulase-negative staphylococci (S. cohnii, S. epidermidis, S. haemolyticus, S. hominis, S. saprophyticus, S. simulans)methicillin kugonjetsedwa tizilombo ta.

Zoyipa: Pseudomonas aeruginosa.

* Kuzindikira kwa moxifloxacin kumatsimikiziridwa ndi zidziwitso zamankhwala.

** Kugwiritsa ntchito Heinemox sikulimbikitsidwa pochiza matenda oyambitsidwa ndi zironda. S. aureuskugonjetsedwa ndi methicillin (MRSA). Pankhani ya matenda okayikiridwa kapena otsimikiziridwa omwe amayambitsidwa ndi MRSA, Chithandizo cha mankhwala oyenera antibacterial ayenera kuikidwa.

Zizindikiro Heinemox

Matenda opatsirana komanso otupa omwe amayambitsidwa ndi tizilombo tating'onoting'ono ta moxifloxacin:

kuchuluka kwa matenda opatsirana,

pachimake bakiteriya sinusitis,

matenda osavuta komanso ovuta a pakhungu ndi minofu yofewa (kuphatikizapo phazi la matenda ashuga),

zovuta zamkati zam'mimba, kuphatikizapo matenda a polymicrobial, kuphatikizapo makasitomala amkati,

zovuta zotupa matenda a m'chiuno ziwalo (kuphatikizapo salpingitis ndi endometritis).

* Streptococcus pneumoniae Ndi mitundu yambiri yoletsa kukonzekera imaphatikizira penicillin zotupa ndi zovuta zomwe zimagonjetsedwa ndi ma cell awiri kapena angapo kuchokera ku magulu monga penicillin (omwe ali ndi MICs ≥ 2 μg / ml), cephalosporins wotsatira (cefuroxime), macrolides, tetracyclines ndi trimethoprim / sulfamethoxazole.

Contraindication

Hypersensitivity kuti moxifloxacin, ma quinolones kapena zigawo zina za mankhwala,

thupi siligwirizana ndi mtedza kapena soya,

kuwonongeka kwa tendon ndi chithandizo cham'mbuyomu ndi quinolones,

kugwiritsa ntchito munthawi yomweyo mankhwala omwe amakulitsa nthawi ya QT (kuphatikizapo mankhwala osokoneza bongo a kalasi IA, III) - onani "Kuchita",

odwala omwe ali ndi nthawi yayitali kapena otenga nthawi yokhala ndi nthawi yayitali ya QT, ma elekitirodi a electrolyte (makamaka osakonzekera hypokalemia), bradycardia yofunika kwambiri, kukomoka kwakukulu mtima ndi gawo lochepetsedwa lamanzere am'mimbamo, mbiri yakusokonekera kwa miyambo yotsatiridwa ndi zizindikiro zamankhwala (kugwiritsa ntchito moxifloxacin Q kumabweretsa ),

odwala omwe ali ndi vuto la chiwindi (gulu la ana-Pugh gulu C) komanso kuwonjezeka kwa zochita za transaminase koposa nthawi 5 kuposa VGN,

ana ochepera zaka 18.

Ndi chisamaliro: Matenda a CNS (kuphatikiza omwe akukayikira kuphatikizidwa kwa CNS) akuwopseza kugwirira ntchito ndikuchepetsa gawo la zochitika zogwira mtima, odwala omwe ali ndi mbiri ya psychosis ndi matenda amisala, odwala omwe ali ndi vuto la proarrhythmic, makamaka ngati azimayi ndi odwala okalamba, myasthenia gravis gravis, cirrhosis ya chiwindi, kugwiritsa ntchito limodzi ndi mankhwala omwe amachepetsa potaziyamu.

Kuchita

Palibenso zovuta zamankhwala zokhudzana ndi moxifloxacin ndi atenolol, ranitidine, calcium zowonjezera, theophylline, kulera kwapakamwa, glibenclamide, itraconazole, digoxin, morphine, probenecid. Kuwongolera kwa mlingo wa mankhwala pophatikizidwa ndi mankhwalawa sikufunika.

Maantacidiyamu, mchere ndi ma multivitamini. Kugwiritsa ntchito pamodzi kwa moxifloxacin ndi kukonzekera kwa antacid, mchere ndi ma multivitamini amatha kusokoneza mayamwidwe a moxifloxacin chifukwa cha mapangidwe a chelate complexes okhala ndi polyvalent cations omwe amapezeka mu mankhwalawa, motero kuchepetsa kuchuluka kwa moxifloxacin m'madzi a m'magazi. Pankhani imeneyi, mankhwala a antacid, antiretroviral (mwachitsanzo didanosine) ndi mankhwala ena omwe ali ndi magnesium, aluminium, sucralfate, chitsulo, nthaka iyenera kutengedwa osachepera maola 4 isanachitike kapena maola 4 atayamwa pakamwa pa moxifloxacin.

Mankhwala omwe amakulitsa nthawi ya QT. Popeza moxifloxacin amakhudza kutalika kwa gawo la QT, kugwiritsa ntchito moxifloxacin palimodzi ndi mankhwala otsatirawa ndi otsutsana: antiarrhythmic IA (quinidine, hydroquinidine, disopyramide, etc.) ndi III (amiodarone, sotalol, dofetilide, ibutilide, etc.) makalasi, maulalo. phenothiazines, pimozide, sertindole, haloperidol, sultopride, etc.), antimicrobial (sparfloxacin, erythromycin, pentamidine, antimalarial mankhwala, makamaka halofantrine), antihistamines (astemizole, terfenadine, misolastine) ndi ena ( kunyada, vincamine, bepridil, difemanil) ndalama.

Warfarin. Akaphatikizidwa ndi warfarin, PV ndi magawo ena a magazi osintha samasintha. Komabe, mwa odwala omwe amalandila ma anticoagulants osakaniza maantibayotiki, kuphatikiza ndi moxifloxacin, pakhala pali milandu yowonjezera ya anticoagulant mankhwala a anticoagulant. Zoyipa ndi kukhalapo kwa matenda opatsirana (ndi kupatsirana kwakanthawi), m'badwo komanso chikhalidwe cha wodwalayo. Ngakhale kuti kulumikizana pakati pa moxifloxacin ndi warfarin sikunapezeke, mwa odwala omwe amalandila chithandizo pamodzi ndi mankhwalawa, ndikofunikira kuwunika mtengo wa INR ndipo, ngati kuli kotheka, sinthani mlingo wa anticoagulants osadziwika.

Digoxin. Moxifloxacin ndi digoxin sizikhudza kwambiri magawo a pharmacokinetic wina ndi mnzake. Ndi Mlingo wa moxifloxacin wobwerezabwereza_max digoxin inachulukira pafupifupi 30%, pomwe mfundo za AUC ndi C_mphindi digoxin sanasinthe.

Yoyambitsa kaboni. Ndi munthawi yomweyo kugwiritsa ntchito mphamvu yoyendetsa kaboni ndi moxifloxacin mkati mwa mlingo wa 400 mg, dongosolo la bioavailability la moxifloxacin limatsika ndi oposa 80% chifukwa choletsa kuyamwa kwake.

GCS. Pogwiritsa ntchito munthawi yomweyo moxifloxacin ndi corticosteroids, chiopsezo chotenga tendonitis ndi kupindika kwa tendon chikuwonjezeka.

Mlingo ndi makonzedwe

Mkati kumeza lonse, osafuna kutafuna, kumwa madzi ambiri, makamaka mukatha kudya. Musapitirire mlingo woyenera.

Kuperewera	Mlingo uliwonse maola 24 (nthawi imodzi patsiku), mg	Kutalika kwa chithandizo, masiku
Chibayo chopezeka pagulu	400	7–14
Kuchulukitsa kwa matenda osakhazikika	400	5–10
Pachimake bakiteriya sinusitis	400	7
Matenda osakhudzika a khungu komanso minofu yofewa	400	7
Matenda ovuta a pakhungu ndi kapangidwe kazinthu zina	400	7–21
Matenda Ovuta a Intraabdominal	400	5–14
Zovuta zotupa matenda amchiberekero	400	14

Musapitirire nthawi yolimbikitsidwa.

Kusintha kwa muyezo wachiperekedwe kumafunikira: odwala okalamba, odwala omwe ali ndi vuto la chiwindi (kalasi A, B pa Child-Pugh wadogo), odwala omwe ali ndi vuto laimpso (kuphatikizapo kuperewera kwambiri kwaimpso ndi creatinine Cl ≤30 ml / min / 1.73 m 2, komanso omwe ali ndi hemodialysis wopitilira nthawi yayitali komanso amakhala kunja, odwala amitundu yosiyanasiyana.

Bongo

Chithandizo: vuto la bongo, munthu akuyenera kutsogoleredwa ndi chithunzi cha chipatala ndikuwonetsa pothandizidwa ndi ECG powunikira. Makonzedwe a adamulowetsa kaboni pambuyo pakamwa makonzedwe a mankhwala kungathandize kupewa kwambiri kuwonekera kwa moxifloxacin milandu bongo.

Malangizo apadera

Nthawi zina, mankhwalawa atagwiritsidwa ntchito koyamba, Hypersensitivity ndi mziwopsezo zimachitika, zomwe zimayenera kuuzidwa kwa adotolo. Nthawi zambiri, zotsatira za anaphylactic zimatha kupitilira mpaka pakubwezeretsa pangozi ya anaphylactic, ngakhale atangoyamba kugwiritsa ntchito mankhwalawa. Muzochitika izi, chithandizo ndi Heinemox ziyenera kusiyidwa ndipo njira zoyenera zothandizira zimatengedwa (kuphatikizapo anti-shock).

Mukamagwiritsa ntchito mankhwala a Heinemox mwa odwala ena, kuwonjezereka kwa nthawi ya QT kumatha kudziwika. Kutalika kwa nthawi ya QT kumalumikizidwa ndi chiwopsezo chowonjezeka cha regricular arrhythmias, kuphatikizapo polymorphic ventricular tachycardia. Pali kulumikizana mwachindunji pakati pa kuwonjezeka kwa kuchuluka kwa moxifloxacin ndi kuwonjezeka kwa nthawi ya QT. Zotsatira zake, mlingo woyenera (400 mg / tsiku) sayenera kupitirira.

Odwala okalamba ndi amayi amakonda kwambiri mankhwala omwe amawonjezera nthawi ya QT. Mukamagwiritsa ntchito Heinemox mankhwala, chiopsezo chotukukira chamitsempha cha m'magazi odwala omwe ali ndi vuto lomwe lingakonzekere kupanga arrhythmias angachuluke. Pankhani imeneyi, mankhwala a Heinemox sangathe kugwiritsidwa ntchito motere: kubadwa kwa nthawi yayitali kapena kupezeka kwa nthawi yayitali ya QT, hypokalemia yopanda tanthauzo, bradycardia yofunikira kwambiri Mankhwala omwe amawonjezera nthawi ya QT (kuphatikiza mankhwala osokoneza bongo a kalasi IA, III) ndi ena (onani "Kuyanjana").

Mukamagwiritsa ntchito mankhwala a Heinemox, milandu ya chiwindi chachikulu cha hepatitis, yomwe ingayambitse kukula kwa chiwindi, yadziwika. Ngati zizindikiro za kukanika kwa chiwindi zimachitika, muyenera kufunsa dokotala musanapitirize chithandizo chamankhwala.

Mukamamwa mankhwala a Heinemox, milandu yokhudzana ndi zotupa zamkati zamkati (Stevens-Johnson syndrome kapena poermal necrolysis) imanenedwapo. Wodwala ayenera kudziwitsidwa kuti ngati pali zizindikiro za pakhungu kapena mucous, ndikofunikira kukaonana ndi dokotala musanapitirize kutenga Heinemox.

Kugwiritsa ntchito mankhwala a quinolone kumalumikizidwa ndi chiopsezo chogwidwa. Heinemox iyenera kugwiritsidwa ntchito mosamala kwa odwala omwe ali ndi matenda amkatikati mwa mitsempha komanso matenda amkati amanjenje omwe amatsogolera kuchitika kwa kugwidwa kapena kuchepetsa kutsika kwa zochitika zopweteka.

Heinemox iyenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi myasthenia gravis. gravis mogwirizana ndi kufalikira kwa matendawa.

Heinemox iyenera kugwiritsidwa ntchito mosamala odwala omwe ali ndi vuto la shuga-6-phosphate dehydrogenase chifukwa cha kutukuka kwa hemolytic.

Kugwiritsa ntchito ma antimicrobials otambalala, kuphatikiza Heinemox, kumalumikizidwa ndi chiopsezo cha pseudomembranous colitis. Kuzindikiritsa izi kuyenera kukumbukiridwa mwa odwala omwe matenda otsegula m'mimba amawonekera panthawi ya chithandizo cha Heinemox. Pankhaniyi, mankhwalawa ayenera kusiyidwa ndipo chithandizo choyenera chikuyenera kuperekedwa. Mankhwala omwe amalepheretsa matumbo kuyenda amayambitsidwa ndikukula kwa matenda otsegula m'mimba.

Pa maziko a quinolone mankhwala, kuphatikizapo moxifloxacin, kukula kwa tendonitis ndi kupindika kwa tendon ndikotheka, makamaka kwa odwala okalamba ndi odwala omwe amalandila corticosteroids amodzi. Pazizindikiro zoyambirira za kupweteka kapena kutupa kwa matendawa, muyenera kusiya kumwa mankhwalawo ndikukulitsa dzanja lanu.

Moxifloxacin alibe chithunzi, komabe, tikulimbikitsidwa kupewa ma radiation ya UV panthawi ya mankhwala dzuwa mwachindunji.

Kugwiritsa ntchito moxifloxacin pochiza matenda oyambitsidwa ndi zotsekemera sikulimbikitsidwa. Staphylococcus aureuskugonjetsedwa ndi methicillin (MRSA). Pankhani ya matenda okayikiridwa kapena otsimikiziridwa omwe amayamba ndi MRSA, mankhwala omwe ali ndi mankhwala oyenera a antibacterial ayenera kuikidwa (onani. Pharmacodynamics).

Kutha kwa mankhwala Heinemox poletsa kukula kwa mycobacteria kungayambitse kuyanjana mu vitro moxifloxacin ndi mayeso a Mycobacterium spp., kumabweretsa zotsatira zabodza zabodza pakusanthula kwa odwala omwe amathandizidwa ndi Heinemox panthawiyi.

Odwala omwe adathandizidwa ndi quinolones, kuphatikizapo Heinemox, milandu yokhudza kupweteka kapena sensorimotor polyneuropathy afotokozedwa, zomwe zimatsogolera paresthesias, hypesthesia, dysesthesia, kapena kufooka. Odwala omwe akuthandizidwa ndi Heinemox ayenera kuchenjezedwa za kufunika kofunsa dokotala musanapitirize kulandira chithandizo kuti mupeze vuto la neuropathy, kuphatikizapo kupweteka, kuwotcha, kumva, kugona kapena kufooka (onani "Zotsatira zoyipa").

Machitidwe amakhudzidwa amatha kuchitika ngakhale atakhazikitsidwa koyamba kwa fluoroquinolones, kuphatikiza moxifloxacin. Nthawi zina, kukhumudwa kapena kusinthasintha kwa malingaliro kumapitilira mpaka pakudzipha komanso chizolowezi chodzivulaza, kuphatikizapo kuyesayesa kudzipha (onani "Zotsatira zoyipa"). Ngati zoterezi zikuchitika mwa odwala, mankhwala a Heinemox ayenera kusiyidwa ndikufunika kuchitapo kanthu.

Chifukwa chofalikira komanso kuchuluka kwa matenda omwe amayamba chifukwa cha fluoroquinolone Neisseria gonorrhoeae, mankhwalawa odwala ndi yotupa matenda a m'chiuno ziwalo, moxifloxacin monotherapy sayenera kuchitika. Kupatula pomwe kukhalapo kwa fluoroquinolone osagwira N. gonorrhöeae kupatula. Ngati sizotheka kupatula kukhalapo kwa fluoroquinolone N. gonorrhoe, ndikofunikira kuthana ndi vuto lothandizira mankhwala othandizira ndi moxifloxacin wokhala ndi mankhwala oyenera omwe amagwira motsutsana N. gonorrhöeae (mwachitsanzo cephalosporin).

Kukopa pa kuyendetsa galimoto ndi makina oyenda. Fluoroquinolones, kuphatikiza moxifloxacin, imatha kuwononga magwiridwe antchito oyendetsa galimoto ndikuchita zina zina zowopsa zomwe zimafuna chidwi chochulukirapo komanso kuthamanga kwa zochitika zama psychomotor chifukwa chazomwe zimayambitsa dongosolo lamanjenje lamkati komanso kuwonongeka kwa mawonekedwe.

Wopanga

Ma Highglans Laboratories Pvt. Ltd E-11, 12 & 13, Site-B, UPSIDC, Surajpur, Industrial Zone, Greater Noida-201306, (U.P.), India.

Tel. +91 (120) 25-69-742, fakisi: +91 (120) 25-69-743.

Imelo: [email protected], www.higlance.com

Woyimira wopanga ku Russian Federation: Pharma Gulu LLC. 125284, Moscow, st. Kuthamanga, 13.

Tel./fax: +7 (495) 940-33-12, 940-33-14.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala a antimicrobial akugulitsidwa mwanjira ya mapiritsi a 400 mg a moxifloxacin (gawo logwira).

Zinthu zina zomwe zikuchokera:

anhydrous colloidal silicon dioxide,
sodium croscarmellose,
ma cellcrystals,
magnesium wakuba,
pech talcum ufa
sodium lauryl sulfate,
3000 macrogol
soya lecithin,
okusayidi wachitsulo,
White Opadry 85G58977.

Zizindikiro zogwiritsidwa ntchito

Njira zotsatirazi zotupa ndi zopatsirana zomwe zimayambitsidwa ndi tizilombo tating'ono zimayamwa mankhwalawa:

chibayo chopezeka ndi anthu chomwe chimakwiya ndi Streptococcus anginosus ndi Streptococcus milleri,
pachimake matenda a bronchitis,
sinusitis (pachimake), oyipitsidwa ndi bakiteriya wa pathogenic,
matenda opatsirana a m'mimba (kuphatikizapo matenda a polymicrobial),
matenda a pakhungu ndi zotupa zofewa,
matenda am'mimba otupa, kuphatikizira endometritis ndi salpingitis.

Heinemox analamula kuti yotupa matenda a m'chiuno ziwalo.
Ndi matenda apakhungu, Heinemox ndi mankhwala.Thrombomagum sinafotokozeredwe kufooka kwa dongosolo la kupuma.
Kumwa mankhwalawa ndi mankhwala a chibayo.
Ndi sinusitis, ndichizolowezi kupatsa Heinemox.

Momwe mungatenge Heinemox

Mapiritsi a antimicrobial ayenera kumwedwa pakamwa yonse, kutsukidwa ndi madzi. Ndikofunika kuchita izi mukatha kudya.

chibayo (mtundu wopezeka ndi anthu ammudzi): mankhwalawa amatengedwa muyezo wa 400 mg, chithandizo chimatenga sabata 1 mpaka 2,
bronchitis (ndi exacerbation): tsiku lililonse kuchuluka kwa mankhwala - 400 mg, nthawi ya makonzedwe - masiku 5-10,
bakiteriya sinusitis: 400 mg ya mankhwala zotchulidwa patsiku, nthawi ya mankhwala 1 sabata,
khungu / subcutaneous matenda: mlingo - 400 mg, nthawi ya mankhwala - 1 mpaka 3 milungu,
intra-m'mimba matenda opatsirana: Mlingo - 400 mg, nthawi ya mankhwala - kuyambira masiku 5 mpaka 14,
zotupa zotupa (zosavuta), zotulutsidwa mu ziwalo za m'chiberekero: pafupifupi tsiku lililonse - 400 mg, nthawi ya makonzedwe - masabata awiri.

Mapiritsi a antimicrobial ayenera kumwedwa pakamwa yonse, kutsukidwa ndi madzi.

Matumbo

zilonda zam'mimba
nseru
kutsegula m'mimba
chisangalalo
kuchepa kwamtima
stomatitis
dysphagia
colitis (mawonekedwe a pseudomembranous),
gastroenteritis.

Pa ntchito ya mankhwala, minyewa kukokana kumachitika.
Ululu pamimba ndi zotsatira zoyipa za mankhwala a Thrombomag.
Mankhwala ndi Heinemox, kuchepa kwa chilakolako chokwanira kumatha.
Mankhwala amatha kuyambitsa matenda otsegula m'mimba.Mukumwa mankhwala a thrombomag, mseru komanso kusanza kumatha kuchitika.

Pakati mantha dongosolo

chizungulire
dysesthesia / paresthesia,
kuwonongeka pakoma
chisokonezo,
kusowa tulo
kukhumudwa
vertigo
kutopa
kugona
Zodabwitsa zamankhwala
mavuto ndi ntchito yolankhula,
achipatiman.

Mukumwa mankhwalawa, kuoneka kwa kufooka wamba ndikotheka.
Chizungulire chosatha ndi zotsatira zoyipa za kutenga Aspirin.
Kusowa tulo ndi chimodzi mwazotsatira za mankhwalawa.
Heinemox angayambitse kugona.

Kuchokera kumbali ya kagayidwe

Hyperuricemia
kuchuluka kwa bilirubin,
hyperglycemia
Hyperlipidemia

eosinophilia
anaphylactic reaction,
zotupa
Edema wa Quincke
laryngeal kutupa (koopseza moyo).

Mavuto akumva ndi dyspnea nthawi zina amatha kuwonekera.

Pa chithandizo ndi Heinemox, kuwonetsedwa kwa vuto la mtima ndikotheka.

Kuyenderana ndi mowa

Wopanga sapereka chidziwitso chokhudza kuphatikiza kumeneku.

Avelox ndi analogue ya Heinemox.
Misonkho ya Heinemox - Maxiflox.
M'malo mwa Heinemox, Vigamox nthawi zina amakhazikitsidwa.Rotomox nthawi zina amakhazikitsidwa m'malo mwa Heinemox.