Mapiritsi otsika mtengo ochepetsa cholesterol - mayina, mitengo ndi malingaliro

Mafuta ambiri amthupi amatsogolera ku matenda amtima. Izi ndizowopsa makamaka, chifukwa zimatha kudwala matenda a mtima, stroko, matenda oopsa, matenda a mtima ndi matenda a mtima. Ndi zizindikiro pamwamba pa 6 mmol pa lita imodzi, dokotala amatipatsa mankhwala ena apadera.

Magulu otsitsa cholesterol ndi awa:

Madera
Fibates
Nicotinic acid
Zowonjezera Atheroclephitis, zotengera zoyera za Verbena ndi zina.

Mankhwala otsika mtengo a statin:

Tulip -10 mg - mapiritsi 30 190-210 ma ruble,
Liptonorm - 20 mg - mapiritsi 30 260-280 ma ruble,
Atorvastin canon 20 mg - 30 mapiritsi 260-280 rubles,
Simvastin 10 mg - 20 mapiritsi - ma ruble 180,
Mapiritsi a Vasilip 10 mg-14 - ma ruble 160.
Cardiostatin 20 mg - mapiritsi 30 - 230 rubles.

Mtengo wa mankhwala otsika mtengo

Ngati mulibe kuganizira nicotinic acid ndi lipoic acid, ndiye kuti mapiritsi a cholesterol otsika mtengo amayamba pa ma ruble 160.

Zowonjezera zimakhala pafupifupi mtengo pama rubleti a 150-600 phukusi lililonse. Komabe, muyenera kudziwa kuti zowonjezera pazakudya sizichiritsa komanso sizikhudza cholesterol yayikulu, koma othandizira kupewa.

Mankhwala otchuka kwambiri a m'badwo wakale ndi ma statins:

Lovastatin (Choletar, Cardiostatin),
Simvastatin (Vasilip, Simgal),
Pravastatin (Lipostat).

M'mabelemu mumakhala kukonzekera komwe mankhwala omwe amapezeka.

Simvastatin yatsimikizira bwino kwambiri:

Amachepetsa kupsinjika
Imachepetsa kuphipha kwamitsempha yamagazi,
Zabwino kwambiri pa mafuta a cholesterol.

M'badwo wachiwiri wa mankhwala, Fluvostatin (Leskol Forte) titha kuzindikira. Komabe, mavuto ambiri adalepheretsa mankhwalawa kutchuka kwambiri pakati pa odwala.

Atorvastatin (Atoris, Tulip, Liprinorm) akugwiritsidwabe ntchito. Atorvastatin ndiotetezeka komanso amakonda kwambiri madokotala ndi odwala.
Ceristatin idachotsedwa, popeza imfa za odwala zidalembedwa. Ichi ndichifukwa chake nthawi zambiri pamakhala kutsutsana za zoopsa ndi ma piritsi, popeza mankhwala ambiri amakhala ndi zotsatira zoyipa.

Mbadwo wachinayi womaliza ukuimiriridwa ndi: Rosuvastatin (Roxer, Kristor, Rosucard) ndi Pitastatin (Livazo). Amadziwika ndi kulekerera kwabwino kwambiri ndipo amatha kutenga nthawi yayitali.

Kodi ma statins ali ndi katundu uti:

Pewani magazi kuundana
Pewani zolemba kuti zisakule ndikutseka zolowe,
Vomerezani zotupa khoma la mtima.

Ma Statist sayenera kutengedwa:

Ndi matenda a chiwindi ndi impso,
Ndi matenda a musculoskeletal system.

Gulu lina la mankhwala ndi ma fiber. Amachepetsa cholesterol chifukwa cha kuwonongeka kwa lipoproteins yotsika, amathanso kukhudzana ndi kufalikira kwa cholesterol kunja kwa zotengera:

Clofibrate (Clofibrin, Clofen, Atromidine),
Bezafibrat (Oralipin, Besalin),
Gemfibrozil (Lipigem, Dopur),
Fenofibrate (Tricor, Elastirin).

Mafayilo amakhala ndi chinthu chomwe chimachokera ku lipoic acid. Zabwino kwambiri ndi gemfibrozil:

Imakhala ndi zotsalira ndipo m'mwezi umodzi zotsatira zake zimakhala zikuwoneka kale.
Komabe, mtengo wapakati wa mankhwala ndi pafupifupi 1,500.

Mankhwala nthawi zambiri amadziwika ndi odwala, koma nthawi zina amawona zovuta:

Kupweteka minofu ndi kufooka
Kuchepetsa kwa hemoglobin
Kuchuluka michere chiwindi.

Mankhwala otsika mtengo

Mankhwala otsika mtengo otchedwa lipoic acid, amawononga ndalama 30 mpaka 40 ruble. Chimodzi mwa mankhwala otsika mtengo kwambiri ndi nicotinic acid. Mtengo wa kulongedza mapiritsi 50 ufunika 50 ma ruble.

Mtengo wa ma statins siwotsika mtengo, ndiye kuti cheke mankhwala amayamba kuchokera ku ma ruble 160 kunyamula. Amatha kufikira 2, 2000 ma rublengati dokotala amupatsa Leskol Forte.

Musaganize kuti ma analogu ndi otsika mtengo kuposa njira zoyambirira. Mankhwalawa amalembedwa moyo, chifukwa chake ndibwino kuyang'ana mndandanda wa contraindication, osati pamtengo. Ngati mankhwalawa amamwa bwino ndikupereka zovuta zochepa, ndiye kuti mutha kupirira.

Ngati mukufuna mapiritsi a cholesterol otsika mtengo, ndiye kuti mutha kusankha:

Mankhwala ena otsitsa cholesterol:

Niacin ndi zakudya zowonjezera kuti muchepetse cholesterol. Pano, palinso zabwino komanso zowawa, chifukwa chake musagule ndalama popanda kufunsa dokotala.
Zipatso: rasipiberi, ntchafu zakumaso, hawthorn, viburnum ndi aronia. Amagwiritsidwa ntchito palimodzi komanso mosiyana.
Zodzola zitsamba: tirigu ndi dandelion mizu, oats, motherwort, yarrow, dieelle ndi ena. Kutenga kwa mankhwala azitsamba kumafunikiranso kuvomerezana ndi adokotala, makamaka ngati mapiritsi adalembedwa kale.

Ubwino ndi zotsatira zoyipa za mankhwala opatsirana ndi lipid

Mwa zabwino za mankhwalawa titha kuzindikira:

kuti amachepetsa kutupa kwa minofu ya mtima,
pumulani ndi kukuza makoma a mitsempha yamagazi
osalola zolembera za atherosclerotic kukula.
Mapiritsi amalembedwa pofuna kupewa mikwingwirima, kugunda kwa mtima komanso ngati matenda akonzanso matenda.

Nthawi zambiri, mapiritsi owunikira cholesterol amakhala abwino, chifukwa kuchuluka kwa magazi kumasintha m'maso ndipo kumayamba madzimadzi ambiri. Zachidziwikire, pali zovuta zina, koma ngati chida chimasankhidwa molondola, ndiye kuti chitha kuchepetsedwa.

Mawonekedwe abwino kwambiri am'badwo waposachedwa

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Mankhwala a cholesterol a m'badwo wotsatira ndi ma statins - mankhwala amakono omwe ali otetezeka kwambiri komanso othandiza ndi rosuvastatin ndi pitavastatin. Kuchita kwa mankhwala a gulu la statin kumakhazikitsidwa ndi kukakamiza kwa HMG-CoA reductase, puloteni yapadera yomwe imayambitsa kapangidwe ka cholesterol m'chiwindi. Njira yochepetsera kapena yoletsa kuchuluka kwa kusintha kwa mankhwala m'thupi kumatchedwa kulepheretsa, ndipo yemwe akutenga mankhwalawo (mankhwala, ife, statin) amatchedwa inhibitor.

Kuyamba kogwiritsidwa ntchito kwa ma statins ku Russia kunayamba zaka 80 zapitazo. Cholinga chachikulu cha mchitidwewu chinali ziwopsezo zowopsa pa chitukuko cha atherosulinosis ndi matenda ena okhudzana ndi odwala, ndipo kuchuluka kwa cholesterol ndi komwe kumapangitsa izi.

Statins idakhala chipulumutso chenicheni kwa odwala, ndipo m'badwo watsopano wamankhwala a gululi, omwe atchulidwa pamwambapa, ali ndi zochepa zotsutsana ndi zotsatira zoyipa, zomwe zidapangitsa kuti azigwiritsa ntchito kwambiri, kuphatikiza odwala odwala komanso achikulire.

Statin adayikidwa m'mibadwo ili motere:

Ine - lovastatin, pravastatin, simvastatin,
II - fluvastatin,
III - atorvastatin, cerivastatin,
IV - rosuvastatin, pitavastatin.

Asanaganize zopatsa ma statins, dokotala amamuwuza kusintha kwa moyo wa wodwalayo: kusintha kwa zakudya, kukana zizolowezi zoyipa, kutsindika zomwe zingakhale zotheka pamasewera. Ngati izi sizithandiza, ndiye kuti ma statins amathandizidwa. Zizindikiro posankha mankhwalawa ndi:

mphamvu zazikulu za chitukuko cha atherosulinosis,
matenda a mtima
kukhumudwa kapena kugunda kwa mtima, komanso kuthekera kwakukulu kwakachitika,
kuchira pambuyo opaleshoni ya mtima,
shuga wokhala ndi cholesterol yambiri,
matenda obadwa nawo okhala ndi cholesterol yayikulu,
chiwopsezo cha matenda amtima atafika zaka 40,
kagayidwe kachakudya
kunenepa.

Contraindication

Mbadwo watsopano wa statins uli ndi zotsutsana pang'ono, koma pali matenda angapo omwe sayenera kunyalanyazidwa. Pofuna kuti musavulaze kwambiri odwala, sizikulimbikitsidwa kuti mutenge ma statin a pathologies:

urolithiasis, pyelonephritis ndi matenda ena a impso,
mphira
Kulakwitsa chithokomiro
mankhwalawa endocrine,
ziwengo zosiyanasiyana za mankhwala,
hepatitis, cirrhosis, mitundu ina ya matenda a chiwindi.

Komanso, cholesterol inhibitors samasonyezedwa kuti azigwiritsidwa ntchito ndi azimayi azaka zakubala, panthawi yapakati komanso pakukonzekera.

Zotsatira zoyipa

Monga tafotokozera pamwambapa, zolengedwa zam'badwo waposachedwa zimasiyana ndi omwe adalipo kale pazotsatira zoyipa zochepa, zomwe pakati pawo zimachepera (pansipa 1% ya odwala) zimadziwika:

kugona tulo tulo, kufuna kugona nthawi zonse masana,
kusamva
mutu
kupweteka m'malo ndi minofu,
kufooketsa kaonedwe ka chakudya,
tachycardia - kuwonjezeka kwa pafupipafupi kwa minofu ya mtima (kupitirira 90 pamphindi),
matumbo
kuchepera kuyendetsa galimoto,
thukuta
chiwindi
kupuma pang'ono, limodzi ndi chifuwa.
myopathy - kuwonongeka kwa mitsempha ndi minofu minofu,
zotupa pakhungu.

Tiyenera kudziwa kuti zoyipa (ndikuwonetsa kwawo ndizovuta kwambiri) zimadziwonetsa kokha miyezi ingapo. Chopangitsa chachikulu cha zotsatira zosasangalatsa ndikusagwirizana ndi mlingo womwe dokotala watchulidwa, komanso nthawi yosagwiritsa ntchito ma statins.

Mndandanda wamankhwala

Makhalidwe oyerekeza ma statins amaperekedwa pagome, momwe mumatha kuwona mitengo yamankhwala osakanikirana, kapena ma jeniki (omwe ali ndi mawonekedwe ofanana ndi mankhwala akuluakulu). Zofananira za gulu la statin ndizotsika mtengo kuposa mankhwala oyambira, omwe mndandanda wawo umafotokozedwera pamibadwo.

Ngati tikulankhula za analogues of statins, ndiye kuti ali ndi mawonekedwe osiyana, koma amalimbikitsidwa matenda ena. Komabe, pankhaniyi, mkhalidwe wapadera uyenera kuperekedwa, chifukwa momwe mankhwalawa amathandizira, zikuwonetsa komanso zotsutsana zidzasiyana kwambiri ndi zomwe mankhwala oyambirirawa amagwiritsidwa ntchito.

Mankhwala, zomwe zimagwira ntchito
(mg)

Mtengo wapakati ku Russia, kutengera zomwe zili pompo ndi kuchuluka kwa mapiritsi (ma ruble)

Dongosolo Loyamba LovastatinCardiostatin 20, 40Russia240-560 Lovacor20Turkey280 Lovasterol20Poland200 PravastatinLipostat 10, 20Russia, USA, Italy500-1200 SimvastatinSimvor 5, 10, 20, 40India200-500 Aries 10, 20Russia450 Vasilip 10, 20, 40Slovenia230 Actalipid 10Iceland420 Simvacol 5, 10, 20, 40Hungary, Israel200 Lachiwiri Lachiwiri FluvastatinLeskol 20, 40, 80Switzerland, Spain2800 CHITSANZO CHachitatu AtorvastatinNovostat 10, 20, 40, 80Russia300-600 Atoris 10, 20, 30, 40Slovenia700 Atomax10, 20India180 Vazator10, 20India240 Liprimar 10, 20, 40, 80USA1500 Lipoford10, 20India150 ZOCHITIRA ZINA RosuvastatinAcorta 10, 20Russia550 Crestor 5, 10, 20, 40Puerto Rico, UK1500 Rosulip 10, 20Hungary600 Rosart 5, 10, 20, 40Malta1500 PitavastatinLivazo1, 2, 4France, Italy1000

Mwa ma statins a m'badwo wotsiriza, mitundu ya rosuvastatin imakhala m'malo oyenera - omwe amafananizidwa ndi Baptist. Zochita zamankhwala zimazindikira kugwira bwino ntchito kwa mankhwalawa, kulolerana modabwitsa ndi thupi. Kuphatikiza apo, akatswiri amagogomezera umboni woyambira wa mtanda, zotsatira zoyipa zochepa, zomwe zimapangitsa kuti athe kupereka mankhwala kwa odwala omwe ali ndi matenda oopsa, kuphatikizapo chibadwire. Mtanda wapamwamba umafanana ndi mtengo wake, womwe umakhala wokwera katatu kuposa mtengo wa ma statins ambiri.

Kukonzekera kwa m'badwo wakale (wachitatu) kuchokera ku cholesterol yayikulu kumayimiriridwa ndi atorvastatin. Ponena za cerivastatin, yemwenso ndi m'badwo wachitatu wama statins, mankhwalawa adabweretsa zotsatira zoyipa kwambiri ndipo adasiya ntchito mu 2001. Chimodzi mwazinthu zodziwika bwino za gulu la atorvastatin ndi atoris, yomwe yatengapo gawo pazophunzira zazikulu 30 za sayansi ndipo pakadali pano imagwiritsidwa ntchito bwino poletsa matenda a mtima ndi stroke ngati mankhwala otetezeka komanso othandiza.

Atoris ikhoza m'malo ndi mankhwala ena omwe ali ndi mawonekedwe omwewo, pakati pawo:

woyambitsa gululi ndi atorvastatin (amapereka mphamvu ngakhale ndi mulingo wochepa wa 10 mg),
atomax (mtengo wotsika mtengo woperekedwa kwa okalamba chifukwa chololera bwino)
ator (mankhwala otsika mtengo omwe amasintha mkhalidwe wa wodwala ndi atherosulinosis ndi mlingo wochepa watsiku ndi tsiku wa 10 mg),
Liprimar (mankhwala okwera mtengo okhala ndi mankhwala osavuta kuchokera ku 10 mpaka 80 mg. Amagwira mwachangu komanso mosatetezeka, amatenga nawo mbali mayesero azachipatala kuti azichita bwino),
tovakard (siyisiyana ndi atoris, imayikidwa kuti ikhale cholowa komanso kukhala ndi cholesterol yambiri).

Ma synorms onse a atoris adadutsa ziyeso zofunikira za chipatala ndipo adziwonetsa ngati mankhwala odalirika a gulu lawo. Upangiri wosankha statin ndi dokotala umatengera mbiri ya wodwala komanso mawonekedwe a thupi lake. Ponena za opanga, ndikofunikira kupereka zokonda osati ku malonda odziwika okha, komanso makampani akuluakulu, popeza eni ake akufuna kugwiritsa ntchito matekinoloje amakono komanso apamwamba kwambiri, omwe amatsimikizira chitetezo cha zinthu zamankhwala.

M'malo mwake, makampani ang'onoang'ono, osatha kuwerengetsa ndalama zochulukirapo, amakakamizidwa kuti apulumutse zochuluka. Nthawi yomweyo, mtundu wa matekinoloje omwe amagwiritsidwa ntchito umakhala ndi vuto, lomwe limakhudza kuyeretsa kochepa kwa zinthuzo, osagwirizana ndi kapangidwe kake ka mankhwalawo, ndipo, chifukwa chake, osakwanira achire.

Ngati tikufanizira atorvastatin ndi rosuvastatin (ndiye kuti, zolengedwa za m'badwo wachitatu ndi wachinayi), mwayiwo udzakhala kumbali ya mankhwala achiwiri monga amakono komanso otetezeka. Kukula kwa rosuvastatin ndi mphamvu yake yokwanira yosungunuka pamagetsi amadzimadzi, yomwe imasunga thanzi la maselo a chiwindi. Kuphatikiza apo, zotsatira za kafukufuku wapadera zawonetsa chitetezo cha machitidwe a mbadwo waposachedwa wa mankhwala pamisempha ya minofu, zomwe sizinganene motsimikiza za atorvastatin.

Ma statin onsewa amapereka njira yothandizirana, kuteteza makoma amitsempha yamagazi kuti achulukane, omwe amachepetsa kwambiri mafuta m'thupi. Pa mlingo womwewo, rosuvastatin amachepetsa cholesterol ndi 8% mwachangu. Kuti mupeze zotsatira zofanana, onse mankhwalawa amafunika mlingo waukulu kwambiri wa atorvastatin poyerekeza ndi m'badwo watsopano wa statins. Kuwonjezeka kwa cholesterol yabwino (kuchuluka kofikira lipoproteins) ndi rosuvastatin 40 mg ndi 11.9%. Nthawi yomweyo, statin ya m'badwo wachitatu imapereka HDL kukula kwa 5.6% yokha ndi mlingo wowirikiza wa 80 mg.

Rosuvastatin imatha kutengedwa mosasamala kanthu za zakudya, atorvastatin imayamwa mosiyana ndi chakudya. Ma statin onsewa ali ndi kufanana kwawo pakuwongolera ntchito ya impso panthawi ya chithandizo.

Poyerekeza simvastatin ndi atorvastatin, ziyenera kukumbukiridwa kuti tikukamba za mankhwala a mibadwo yoyamba ndi yachitatu (yamakono). Chifukwa chake, ntchito yayikulu kwambiri ya atorvastatin ndiyomveka: kumwa Mlingo wocheperako wa mankhwala wachitatu ndi wofanana ndi waukulu waukulu wa simvastatin.

Dokotala amapanga chisankho m'malo mwa chimodzi mwazomwezi, kupatsanso wodwalayo mankhwala owonjezera chifukwa chogwirizana ndi mankhwalawo chifukwa cha cholesterol yayikulu.

Kusankha pakati pa rosuvastatin ndi simvastatin popanda machitidwe ena kumathandizira rosuvastatin - mankhwala a m'badwo waposachedwa, omwe ali ndi kuthekera kwachidziwitso pamlingo wofanana ndipo ndiye otetezeka. Ngati mankhwalawa saphatikizidwa ndi rosuvastatin, simvastatin ndi mankhwala.Apa mankhwalawa adzakulitsidwa, koma mankhwala omwe adagwiritsidwa ntchito kale amakhalapo, omwe nthawi zambiri amakhala ofunika kwambiri.

Popeza ma statins amalamulidwa kwa nthawi yayitali chithandizo, kwa odwala ambiri, funso la mtengo wa mankhwalawo silotsiriza. Makampani ogulitsa mankhwala amapereka makasitomala otsika mtengo otchipa ama mtengo wamtengo wapatali, osatsika mtengo pamankhwala oyambira. Mwachitsanzo, m'malo mwa mtanda (ma ruble 1,500), mutha kugula zophatikiza ndi zinthu zomwezo (rosuvastatin), koma pamtengo wokwanira: akorta (550 rubles), rosulip (600 rubles).

Njira yabwino komanso yotsika mtengo kwa liprimar (ma ruble 1,500, mankhwala a gulu la atorvastatin) ndi novostat (ma ruble 450), atoris (700 ma ruble). Mankhwala otsika mtengo kwambiri a cholesterol ndi mankhwala a gulu la simvastatin okhala ndi mtengo wa ma ruble 200-450. M'pofunika kuganizira kulongedza komwe kuli koyenera nthawi yonse ya chithandizo. Chifukwa chake, mitundu yaying'ono kwambiri yamapiritsi ndi makapisozi siziganiziridwa.

Ma statin amatha kugulitsidwa otsika mtengo kuposa anzawo akunja ndi ma syonms. Izi zikuphatikiza mankhwala:

Ndi yogwira simvastatin (aries, atherostat),
kutengera atorvastatin (atorvastatin-Obl, novostat),
ndi yogwira mankhwala rosuvastatin (rosuvastatin canon, Sz, akorta).

Kugwirizana kwina ndi mankhwala ena

Wodwala akakhala ndi matenda angapo, amayenera kumwa mankhwala osiyanasiyana nthawi imodzi, omwe nthawi zonse sangaphatikizidwe. Mukamapereka mtundu watsopano wa ma statins, ndikofunikira kuganizira momwe zimagwirizana ndi mankhwala.

Ngati wodwala amatenga cyclosporine (wogwiritsidwa ntchito poika ziwalo ndi ziwalo, monga zimaletsa kukana kwawo), ndiye kuti kugwiritsa ntchito mankhwalawa ndi rosuvastatin kumayambitsa kuchuluka kwa statin, komwe kumayambitsa mavuto osafunikira. Pitavastatin imagwiranso molakwika ku cyclosporine ndipo imapangidwa kuti igwiritsidwe ntchito palimodzi.

Kuphatikiza kwa antithrombotic mankhwala a warfarin ndi rosuvastatin amakulitsa nthawi ya prothrombin (amafunika kubwezeretsa umphumphu wamagazi). Pankhaniyi, ndikofunikira kusintha mlingo wa statin m'njira yochepetsera, yomwe imakhudza kuthandizira kwa mankhwalawa. Kugwiritsidwa ntchito kwa pitavastatin nthawi imodzi ndi warfarin sikukuwonongerani chithandizo. Mitundu yamibadwo yam'mbuyomu imatha kuchita ukamacheza ndi warfarin, ngati rosuvastatin. Chifukwa chake, nthawi ya prothrombin muzochitika izi imayang'aniridwa ndikuwongolera kovomerezeka.

Protease inhibitors (kuletsa kukula kwa kachilombo ka HIV) ndi kuphatikiza kwa rosuvastatin kumayambitsa kupweteka kwa minofu ndi impso. Kugwirizana kwa pitavastatin pang'ono kumasintha mphamvu ya statin.

Pali mitundu ingapo ya mankhwala omwe mawonekedwe a statin amafunikira chithandizo:

erythromycin (kuchokera ku matenda opatsirana komanso otupa) - mphamvu ya rosuvastatin ndi erythromycin yafupika. Pitavastatin imapatsidwanso mankhwala osiyanasiyana, chifukwa imachulukitsa,
njira zakulera pakamwa - motsutsana ndi maziko a rosuvastatin, kupendekera kwawo kumawonjezeka,
Ma fibrate nawonso sagwirizana ndi rosuvastatin, chifukwa amatha kuwonjezera chiopsezo chokhala ndi myopathy (kuwonongeka kwa minofu minofu). Popewa zovuta zotere, pitavastatin iyenera kugwiritsidwa ntchito mosamala.

Mankhwalawa samangokhala mndandanda wazamankhwala omwe sangathe kapena ayenera kuphatikizidwa mosamala kwambiri ndi ma genins atsopano. Chifukwa chake, kudikirira konse kuyenera kuchitidwa kokha ndi dokotala.

Zowopsa ndi Zopindulitsa

Ma statins a m'badwo waposachedwa ndi omwe amathandizira m'malo mwake adapangidwa mwanjira yoti ikhale yothandiza kwambiri pochiza matenda a atherosulinosis ndi matenda ena okhudzana nawo. Ma statins abwino kwambiri mpaka pano: acorta, rosuvastatin, roxer, tevastor, rosucard, rosulip, mertenyl, mtanda, pitavastatin. Mankhwalawa amapezeka mu Mlingo wosiyanasiyana wa zinthu zomwe mumagwiritsa ntchito, zomwe mungasankhe zofunikira. Achire othandizira amafikira 90% pofika kumapeto kwa sabata lachiwiri. Pakatha mwezi umodzi, zotsatira zake zimakhala zochuluka ndikuyenda bwino.

Ndi kuyang'anira chithandizo nthawi zonse, mankhwalawa amaloledwa bwino, mavuto ake ndi osowa.

Phindu la ma statins amakono ndi:

Kuchepetsa 40% ya kufa chifukwa cha matenda amtima
30% Kuchepetsa chiopsezo cha matenda a mtima ndi sitiroko,
malinga ndi mankhwala, cholesterol imachepetsedwa ndi 45-55%,
kusowa koopsa,
palibe chiopsezo cha khansa mutatenga ma statins, omwe amatsimikiziridwa ndi maphunziro akulu ozama,
Mankhwala ambiri amapangitsa kuti zitheke kugula mankhwala pamtengo wotsika mtengo,
mutha kulembera ndalama kuyambira wazaka 40,
Kuchepetsa kwamphamvu kwa odwala omwe ali ndi zaka zopitilira 75.

Mawonekedwe

Kuchepa kwa chiwindi kumafuna kuchuluka kwa ma statins osankhidwa ndi dokotala. Izi makamaka zimakhala rosuvastatin (mosamala, muyezo wa 10 mg) kapena pravastatin. Nthawi yomweyo, thanzi la wodwala ndikuwunika limayang'aniridwa nthawi zonse. Kuteteza chiwindi ku zotsatira zamankhwala, mankhwala a coenzyme Q10 amathanso kuikidwa.

Mankhwala othandiza komanso otetezeka a anthu odwala matenda ashuga ndi rosuvastatin (poyambira), simvastatin ndi lovastatin. Chisankhocho chimapangidwa poyang'ana mbali zonse za matenda a wodwala.

Ngakhale kuonekera kwaposachedwa kwambiri kwa mbadwo waposachedwa wa ma statins, madokotala amapereka mankhwala omwe adapangidwa kale m'dera lino, chifukwa mawonekedwe a thupi, mphamvu za matendawa, ndi zina zina zimayang'aniridwa. Ngati cholesterol yayikulu simatsatiridwa ndi kuwonongeka kwa mtima, ndiye kuti ndizotheka kupulumutsa zinthuzo popanda kupereka ma statins. Pachifukwa ichi, ndikulimbikitsidwa kuti muzitsatira zakudya ndikukhalabe ndi moyo wogwira ntchito.

Zoyipa

Kuvulala kwa ma statins ndi mankhwala, motero dokotala amayenera kupereka mankhwala mosamala, poganizira zotsutsana ndi zoyipa. Chiwopsezo chochepa kwambiri chikugwiritsa ntchito m'badwo waposachedwa wa ma statins. Chofunikira kwambiri ndikugwiritsa ntchito moyenera, kuwongolera mosamalitsa njira ya chithandizo ndikusintha ngati kuli koyenera, komwe kudzakuteteza motsutsana ndi kuwoneka kosayenera kwa ma statins.

Zambiri zofunika kuziganizira

Kugwiritsa ntchito ma statins nthawi zonse kumateteza thupi ku ziwopsezo zowopsa monga infrction ya myocardial komanso stroke. Zotsatira za kukana zopanda maziko kwa ma statins zatsimikiziridwa ndi kafukufuku wamkulu wasayansi wochitidwa ku Finland ndi UK. Chifukwa chake, kusokonezeka pakupitiliza kwa mankhwala a statin kunadzetsa chiopsezo chotenga matenda: zamtima - mwa 25%, coralary syndrome - mwa 44%, sitiroko - ndi 33%. Imfa za odwala zimachulukanso.

Owerenga athu adagwiritsa ntchito bwino Aterol kutsitsa cholesterol. Kuwona kutchuka kwa malonda, tidaganiza zoperekera chidwi chanu.

Muzochita zachipatala, pamakhala zochitika pamene ma statins samawonetsedwa kwa wodwala pazifukwa zosiyanasiyana. Ndiye mankhwala othandizira amapulumutsa: coenzyme Q10, niacin, hexanyacinatinositol, tocotrienols, beta-sitosterol.

Malinga ndi akatswiri, rosuvastatin ndi Baptist amadziwika kuti ndi malo otetezeka komanso othandiza kwambiri, malinga ndi akatswiri. Mkhalidwe wokhawo womwe statin idzaululira za mikhalidwe yake momwe angathere ndi nthawi yovomerezeka, yomwe ikuyerekezedwa zaka, popeza cholinga chopereka mankhwala ndikuteteza munthu ku matenda amtima omwe angamuphe.

Wodwala ngati sangathe kugula mankhwalawa pazifukwa zachuma, dokotala amasankha cholowa m'malo mwake ndi umboni wabwino, mwachitsanzo, mertenyl, roxer, tevastor.

Mbadwo waposachedwa kwambiri wama statin adapangidwa kuti apange kutulutsa kofunikira kwambiri munthawi yochepa kwambiri yokhala ndi chitetezo chamtundu umodzi. Kusankha kwayekha kwa zovuta zovuta izi ndizomwe zimayambitsa zovuta komanso zovuta zoyipa. Chifukwa chake, kusankha kwamankhwala kuyenera kuchitidwa ndi adokotala okha, ndipo wodwalayo amafunikira moleza mtima komanso mosamala kutsatira maphunziro a mankhwala.

Ma Statistics: momwe amathandizira, zikuwonetsa komanso kuphwanya, kuwunika kwa mankhwala, zomwe zingachitike

Cholesterol, kapena cholesterol, ndi chinthu chomwe chimagwira ntchito zofunika mthupi la munthu. Izi zikuphatikiza:

Kutengapo gawo ngati chida chomanga cha pafupifupi maselo onse amthupi, popeza mamolekyu a cholesterol amaphatikizidwa ndi membrane wa cell ndikupatsa mphamvu, kusinthasintha ndi "fluidity",
Kutenga nawo gawo pa chimbudzi ndi mapangidwe a bile acids wofunikira pakuwonongeka ndikufinya kwa mafuta m'matumbo am'mimba,
Kutenga nawo gawo pakapangidwe kwamahomoni m'thupi - mahomoni a steroid a tiziwalo timene timatulutsa ndi mahomoni ogonana.

Kuchuluka kwa cholesterol m'magazi kumabweretsa kuti ma molekyulu ake owonjezera amatha kuyikika pazitseko zamitsempha yamagazi (makamaka mitsempha). Mapangidwe a atherosulinotic amapangidwa omwe amasokoneza magazi oyenda kudzera mu mtsempha wamagazi ndipo nthawi zina, pamodzi ndi zigawo za magazi zomwe zimamangiriridwa, zimatseka lumen ya chotengera, zomwe zimathandizira kukulitsa kugunda kwa mtima komanso sitiroko.

Muyezo wa cholesterol yathunthu m'magazi a munthu wamkulu sayenera kupitirira 5.0 mmol / l, mwa odwala omwe ali ndi matenda a mtima osaposa 4.5 mmol / l, komanso kwa odwala omwe ali ndi infration ya myocardial osaposa 4.0 mmol / l.

Kodi ma statins ndi chiyani ndipo amagwira ntchito bwanji?

Muzochitika zomwe wodwalayo ali ndi chiopsezo chowonjezereka cha myocardial infarction chifukwa cha atherosulinosis ndi cholesterol metabolism, amamuwonetsa kugwiritsa ntchito mankhwala osachepera lipid.

Statins ndi hypolipidemic (lipid-kutsitsa) mankhwala, limagwirira zake zomwe tikulepheretsa enzyme yomwe imalimbikitsa kupanga cholesterol. Amagwiritsa ntchito mfundo ya "palibe enzyme - palibe cholesterol." Kuphatikiza apo, chifukwa cha njira zosadziwika, amathandizira kusintha kwa mitsempha yamkati yowonongeka pamitsempha pomwe atherosulinosis ikadali yosatheka kuzindikira, koma mawonekedwe a cholesterol pamakoma ayamba kale - kumayambiriro kwa atherossteosis. Amathandizanso pakutsata magazi a magazi, kutsitsa mamasukidwe akayendedwe, chomwe ndichinthu chofunikira chomwe chimalepheretsa mapangidwe amwazi ndi kudziphatika kwawo pamapepala.

Zothandiza kwambiri pano ndizodziwika bwino monga m'badwo waposachedwa kwambiri wa statins, wokhala ndi atorvastatin, cerivastatin, rosuvastatin ndi pitavastatin ngati chinthu chogwira ntchito. Mankhwala a m'badwo waposachedwa samangoletsa kuchuluka kwa cholesterol "yoyipa", komanso kuwonjezera "zabwino" m'magazi. Awa ndi ma statins abwino kwambiri mpaka pano, ndipo kugwiritsa ntchito kwawo kumayamba kale mwezi woyamba wogwiritsidwa ntchito mosalekeza. Statin amalembedwa kamodzi patsiku usiku, kuphatikiza kwa iwo piritsi limodzi ndi mankhwala ena a mtima ndikotheka.

Kugwiritsira ntchito mwaulere kwa ma statins popanda kufunsa dokotala sikovomerezeka, popeza musanamwe mankhwalawa, ndikofunikira kudziwa mulingo wa cholesterol m'magazi. Kuphatikiza apo, ngati cholesterol yotsika kuposa 6.5 mmol / l, pakatha miyezi isanu ndi umodzi muyenera kuyesa kutsitsa ndi zakudya, moyo wathanzi, ndipo pokhapokha ngati izi sizikuyenda bwino, dokotalayo amasankha kukhazikitsidwa kwa ma statins.

Kuchokera pazomwe mungagwiritse ntchito ma statins, mutha kuwunikira mfundo zazikulu:

Zisonyezo za ma statins

Chizindikiro chachikulu ndi hypercholesterolemia (cholesterol yayikulu) ndi kusagwira kwa njira zosagwiritsa ntchito mankhwala osokoneza bongo komanso cholowa chamagulu (cholowa) hypercholesterolemia ndi kusagwira bwino kwa zakudya.

Kukhazikitsa ma statins ndikofunikira kwa anthu omwe ali ndi hypercholesterolemia yokhudzana ndi matenda otsatirawa, chifukwa kugwiritsa ntchito kwawo limodzi ndi mankhwala ena omwe adalembedwa ndi adokotala kumachepetsa chiopsezo cha kufa mwadzidzidzi kwamtima:

Anthu opitirira 40 omwe ali ndi chiwopsezo chachikulu cha matenda amtima,
Matenda a mtima, angina pectoris,
Myocardial infaration
Opaleshoni ya aorto-coronary bypass kapena stent yokhazikitsidwa kwa myocardial ischemia,
Stroko
Kunenepa kwambiri
Matenda a shuga
Milandu yakufa mwadzidzidzi kwamtima wa pachibale pafupi ndi zaka 50.

Zotsatira zoyipa

Osakwana 1% ya odwala omwe amatenga ma statins kwa nthawi yayitali ndikupitiliza kukwiya, kusokonezeka kwa minofu, kufooka kwa minyewa, kuchepa kwa kumva, kutsukidwa, mtima, kuchepa kwambiri komanso kuwonjezeka kwa kuthamanga kwa magazi, kuchepa kwa magazi m'magazi, mphuno , kupweteka kwam'mimba, nseru, chosakhazikika, kukoka mobwerezabwereza, kuchepa kwam'mimba, kupweteka kwa minofu ndi mafupa, rhabdomyolysis (kuwonongedwa kwa minofu minofu), kuchuluka thukuta, thupi lawo siligwirizana.

Oposa 1% ya odwala amakhala ndi chizungulire, nseru, mtima, kupuma, kutsekeka kwa mphuno, zotumphukira edema, chidwi chamtundu wa dzuwa, kuwala kwa pakhungu - kuyabwa, redness, chikanga.

Kodi ma statins angaphatikizidwe ndi mankhwala ena?

Malinga ndi malingaliro a WHO ndi American Heart Association, ma statins ndi mankhwala ofunikira pakuthandizira matenda a mtima omwe ali ndi chiwopsezo chachikulu cha zovuta komanso kuphwanya kwa myocardial. Kukhazikitsa mankhwala okha kuti muchepetse cholesterol sikokwanira, chifukwa chake mankhwala ofunika amaphatikizidwa muzoyimira - awa ndi beta - blockers (bisoprolol, atenolol, metoprolol, etc.), antiplatelet agents (aspirin, aspirin Cardio, aspicor, thrombo Ass, etc.), ACE inhibitors ( enalapril, perindopril, quadripril, etc.) ndi ma statins. Kafukufuku wambiri wachitika omwe amatsimikizira kuti kugwiritsa ntchito mankhwalawa mophatikiza ndi kwabwino. Komanso, kuphatikiza kwa, mwachitsanzo, pravastatin ndi aspirin piritsi limodzi, chiwopsezo chotenga myocardial infarction (7.6%) chimachepetsedwa kwambiri poyerekeza ndi kumwa mankhwala okha (pafupifupi 9% ndi 11% mukamamwa pravastatin ndi aspirin, motsatana).

Chifukwa chake, ngati ma statin adayikidwa usiku pamaso, ndiye kuti, panthawi yokhapokha kuti asamwe mankhwalawa, gulu lachipatala padziko lonse lapansi pano likumaliza kuti kumwa mankhwala ophatikizidwa piritsi limodzi ndikwabwino. Pazophatikiza izi, mankhwala omwe amatchedwa polypill pano akuyesedwa, koma ntchito yawo yochulukirapo idakali ochepa. Mankhwala omwe agwiritsidwa kale ntchito mosakaniza ndi atorvastatin ndi amlodipine - caduet, duplexor.

Ndi cholesterol yayikulu (yoposa 7.4 mmol / l), kugwiritsa ntchito ma statin osakanikirana ndi mankhwala ndikotheka kuti kuthetsere gulu lina - fibrate. Kusankhidwa kumeneku kuyenera kuchitidwa ndi dokotala, kuwunika mosamala kuopsa kwa zotsatirapo zake.

Simungathe kuphatikiza kutenga ma statins ndi madzi a mphesa, chifukwa zimakhala ndi zinthu zomwe zimachepetsa kagayidwe kazomwe zimapanga thupi ndikuwonjezera kuchuluka kwake m'magazi, omwe amadzala ndi kukula kwa poyipa wamavuto.

Komanso, musamamwe mankhwalawa ndi mowa, maantibayotiki, makamaka ufafanuzi wa hemithromycin ndi erythromycin, chifukwa izi zimatha kuyambitsa chiwindi. Maantibayotiki ena ophatikizidwa ndi mankhwala ochepetsa cholesterol ndi otetezeka. Kuti muwone ntchito ya chiwindi, ndikofunikira kuyesa magazi a biochemical miyezi itatu iliyonse ndikuwona kuchuluka kwa ma enzymes a chiwindi (AlAT, AsAT).

Ubwino wotenga ma statins

Kuchepetsa 40% yaimfa yamtima m'zaka zisanu zoyambirira,
30% Kuchepetsa chiopsezo cha matenda a stroko,
Kuchita bwino - kutsitsa cholesterol ndikugwiritsidwa ntchito mosalekeza ndi 45 - 55% ya oyamba kwambiri. Kuti muwone kuyendetsa bwino, wodwalayo amayenera kuwezetsa magazi mwezi uliwonse chifukwa cha cholesterol,
Chitetezo - kutenga mbadwo waposachedwa wa ma statins mu mankhwala othandizira alibe mphamvu yakuopsa m'thupi la wodwalayo, ndipo chiopsezo cha zovuta zake ndizochepa kwambiri. Kafukufuku wambiri omwe akuchita kuwunika kwakanthawi kwa odwala omwe akhala akutenga ma statins kwa nthawi yayitali akuwonetsedwa kuti kugwiritsa ntchito kwawo kukhoza kuyambitsa chitukuko cha matenda a shuga 2, khansa ya chiwindi, matenda amtundu wa m'mimba komanso kuwonongeka kwa malingaliro. Komabe, izi zatsimikiziridwa ndikuwonetsa kuti matendawa amatenga chifukwa cha zina. Kuphatikiza apo, ku Spain kwa odwala omwe ali ndi mtundu wachiwiri wa matenda ashuga omwe alipo kale kuyambira 1996 kwawonetsa kuti chiopsezo chotenga matenda a shuga monga matenda ashuga polyneuropathy, retinopathy amachepetsa ndi 34% ndi 40%, motero.
Chiyerekezo chochulukirapo chomwe chimagwira ntchito imodzi m'magulu osiyanasiyana amtengo, zomwe zimathandiza kusankha mankhwala poganizira mphamvu zomwe wodwalayo ali nazo.

Zoyipa zovuta kutenga ma statins

Mtengo wokwera wa zokonzekera zina zoyambirira (mtanda, rosucard, leskol forte). Mwamwayi, drawback iyi imachotsedwa mosavuta pakusintha mankhwala pogwiritsa ntchito zomwezo ndi analogue yotsika mtengo.

Inde, zabwino ndi mapindu osayerekezekawa ayenera kukumbukiridwa ndi wodwala yemwe akuwonetsa kuti akuvomera, ngati akukayika ngati kuli koyenera kutenga ma statins ndikuyesa mosamala zabwino ndi zoipa zake.

Mwachidule

Mndandanda wa mankhwala omwe nthawi zambiri amaperekedwa kwa odwala amaperekedwa patebulo:

Dzina la mankhwalawa, zomwe zimapezeka mu mankhwala (mg)

Mtengo woyerekeza, rub

Ine m'badwo SimvastatinVasilip (10, 20 kapena 40)Slovenia355 — 533 Simgal (10, 20 kapena 40)Czech Republic, Israel311 — 611 Simvakard (10, 20, 40)Czech Republic262 — 402 Simlo (10, 20, 40)India256 — 348 Simvastatin (10, 20 kapena 40)Serbia, Russia72 — 177 PravastatinLipostat (10, 20)Russia, USA, Italy143 — 198 LovastatinHolletar (20)Slovenia323 Cardiostatin (20, 40)Russia244 — 368 M'badwo wachiwiri FluvastatinLeskol Forte (80)Switzerland, Spain2315 M'badwo wa III AtorvastatinLiptonorm (20)India, Russia344 Liprimar (10, 20, 40, 80)Germany, USA, Ireland727 — 1160 Torvacard (10, 40)Czech Republic316 — 536 Atoris (10, 20, 30, 40)Slovenia, Russia318 — 541 Tulip (10, 20, 40)Slovenia, Sweden223 — 549 M'badwo wa IV RosuvastatinCrestor (5, 10, 20, 40)Russia, Great Britain, Germany1134 – 1600 Rosucard (10, 20, 40)Czech Republic1200 — 1600 Rosulip (10, 20)Hungary629 – 913 Tevastor (5, 10, 20)Israeli383 – 679 PitavastatinLivazo (1, 2, 4 mg)Italy2350

Ngakhale kufalikira kotereku pamitengo yama statins, ma analogi otsika mtengo samakhala otsika kwambiri pamankhwala okwera mtengo. Chifukwa chake, ngati wodwalayo sangathe kugula mankhwalawo, ndikotheka kusintha m'malo mwake monga momwe adanenera adotolo ndi omwe ali ndi ndalama zambiri.

Kodi ndingachepetse cholesterol yanga popanda mapiritsi?

Mankhwala a atherosulinosis monga mawonekedwe a cholesterol yoipa “yambiri” m'thupi, mankhwala oyamba ayenera kukhala olimbikitsa kusintha kwa moyo, chifukwa ngati cholesterol mulibe kwambiri (5.0 - 6.5 mmol / l), ndipo chiopsezo cha zovuta zamtima ndi chochepa kwambiri, mutha kuyesa sinthani izi mothandizidwa ndi izi:

Zakudya zoyenera, bungwe la regimen la chakudya kupatula mafuta, okazinga zakudya. Zokonda zimaperekedwa muzakudya zampweya, zophika, zopatsa mphamvu. Kudyedwa kwa mazira (yolks), nyama yamitundu yamafuta, offal (chiwindi ndi impso), zinthu zamkaka ndizochepa. Ndikofunikira kuti musatengeko zinthu izi, koma muzigwiritsa ntchito moyenera mogwirizana ndi mfundo za chakudya choyenera, chifukwa thupi limafunikira cholesterol ngati chida chomanga bongo, chiwindi, maselo amwazi ndi ziwalo zina. Chifukwa chake, musamadye zakudya zomwe zili ndi zonse.
Zochita zolimbitsa thupi zoyenera mkhalidwe wamtima wamatsenga (kuyenda, masewera olimbitsa thupi, zochitika mu mpweya wabwino, ndi zina zambiri).
Kukana zizolowezi zoipa, asayansi atsimikizira kuti kumwa mowa mwauchidakwa komanso kusuta fodya kumawonjezera cholesterol yamagazi.

Zakudya zina zimakhala ndi zotchedwa zachilengedwe. Mwa zinthu izi, adyo ndi turmeric ndizophunziridwa kwambiri. Kukonzekera kwa mafuta a nsomba kumakhala ndi mafuta omega 3 acids, omwe amathandizira kagayidwe ka cholesterol mthupi. Mutha kumwa mafuta a nsomba, ogulidwa ku malo ogulitsira mankhwala, kapena mutha kuphika mbale za nsomba (trout, nsomba, nsomba, etc.) kangapo pa sabata. Mitengo yokwanira ya masamba, yomwe imapezeka muma maapulo, kaloti, phala (oatmeal, barele) ndi nyemba, ndilolandiridwa.

Pokhapokha pakuchitika njira zosagwiritsa ntchito mankhwala osokoneza bongo, adotolo amafunsa imodzi ya mankhwala ochepetsa lipid.

Pomaliza, ndikufuna kudziwa kuti, ngakhale ali ndi mantha a odwala komanso lingaliro la zoopsa za ma statins, cholinga chawo ndicholondola pakufikira kwa atherosclerosis ndi kuwonongeka kwamitsempha yama coronary, popeza mankhwalawa amatalikitsa moyo. Ngati muli ndi cholesterol yayikulu popanda chizindikiro choyambirira cha kuwonongeka kwa mtima, ndiye kuti muyenera kudya moyenera, kusunthika, kukhala ndi moyo wathanzi, kenako mudzaganiza kuti mutenge ma protein.

Mapiritsi ochepetsa cholesterol yamagazi: mndandanda, mitengo, mayina

Imakhazikika pamisempha ya shuga kwa nthawi yayitali
Imabwezeretsa kapangidwe ka insulin

Ndi kuchuluka kwa lipoprotein otsika kwambiri, ndikofunikira kuchitapo kanthu pofuna kutsitsa mtengo. Pali mitundu yambiri yamankhwala yomwe imakhudza bwino kagayidwe ka mafuta ndikuletsa mapangidwe a LDL.

Kuti muchepetse cholesterol, mankhwala amaikidwa omwe ali m'gulu la ma statins kapena ma fiber. Ndalama zomwe zatsimikiziridwa zaka zapitazo. Amalembedwa panthawi yomwe njira zina zochiritsira - zakudya zaumoyo, zolimbitsa thupi, kuchepa thupi, ndi zina zambiri, sizinapatse zotsatira zomwe mukufuna.

Mankhwala ambiri amatha kugulidwa ku pharmacy popanda mankhwala a dokotala. Koma izi sizitanthauza kuti wodwala matenda ashuga amatha kudzilingalira. Kuti mukwaniritse zochizira, mathandizidwe amomwemo kuti mugwiritse ntchito mankhwala amafunikira.

Ganizirani mapiritsi amomwe amachepetsa cholesterol m'thupi ndi abwino, momwe angamwere bwino, ndipo ndi zovuta ziti zomwe zingachitike ndi odwala omwe ali ndi matenda ashuga?

Mfundo yopangira ma statins

Mapiritsi a cholesterol a gulu la statin ndi omwe amapatsidwa nthawi zambiri. Mankhwala amathandizira kuchepetsa kuchuluka kwa lipoproteins otsika m'thupi, kuchepetsa kupezeka kwa LDL m'chiwindi cha wodwalayo. Ziwerengero zikuwonetsa kuti OH (cholesterol yathunthu) imachepetsedwa ndi 30-45% ya gawo loyambirira, komanso kuchuluka kwa zinthu zoyipa ndi 40-60%.

Chifukwa cha kugwiritsa ntchito ma statins, ma lipoproteins okwera amatha kuchulukitsidwa, ndipo mwayi wopanga zovuta za ischemic mu matenda ashuga umatsitsidwanso ndi 15%. Ma Statin samapereka mutagenic ndi carcinogenic zotsatira, zomwe ndizotsimikizika kuphatikiza.

Kudzichiritsa nokha pa mapulani otere ndikoletsedwa. Popeza kuwunika kokwanira kwa wodwalayo kumafunikira kuti athe kuwunika onse owopsa ake. Mukamapereka mankhwala, dziwani izi:

Kukhalapo / kusakhalapo kwa zizolowezi zoyipa,
Okwatirana
Gulu la odwala
Matenda oyamba (matenda oopsa, matenda a shuga, ndi zina).

Ngati mungafune mankhwala kuchokera ku ma statins, mwachitsanzo, Atorvastatin, Simvastatin, Zokor, Rosuvastatin, ndiye ayenera kutengedwa pa mlingo womwe woyesedwa ndi katswiri wa zamankhwala amapanga. Mankhwala, kuyezetsa magazi kwamomwe amadziwika nthawi ndi nthawi kuyang'anira zizindikiro.

Mapiritsi ochepetsa cholesterol yamagazi siotsika mtengo. Ngati wodwalayo sangathe kugula mankhwala aliwonse, ndiye kuti sikulimbikitsidwa kuti azisankha yekha analogue. Tiyenera kufunsa adotolo kuti apereke njira ina yomwe ingagwirizane ndi mtengo wa odwala matenda ashuga. Chowonadi ndi chakuti zamagetsi opanga zoweta ndizoperewera kwambiri pamakhalidwe ndi ochiritsira osati mankhwala oyamba okha, komanso ma generics opanga akunja.

Ngati chithandizo chikusainidwa kwa munthu wachikulire, kulumikizana ndi mankhwala ochizira matenda am'mimba, matenda oopsa, komanso matenda oopsa a shuga kuyenera kukumbukiridwa. Panthawi imeneyi, odwala ali ndi chiopsezo chowirikiza cha myopathy.

Statin tikulimbikitsidwa kuganizira izi:

Pamaso pa matenda amchiwindi osakanikirana, ndibwino kumwa Rosuvastatin, koma osachepera mlingo, womwe umapereka zotsatira. Kugwiritsa ntchito kwa mankhwala a Pravaxol ndikololedwa. Mankhwalawa alibe zotsatira zoyipa ku chiwindi, koma samaphatikizidwa ndi mowa komanso antibacterial.
Ngati wodwala matenda ashuga apweteka pafupipafupi, kapena pali kuwonongeka kwawo, ndibwino kugwiritsa ntchito Pravastatin. Mankhwalawa alibe poizoni m'mitsempha ya wodwala, chifukwa chake chiopsezo chokhala ndi myopathy ndi matenda a shuga chimachepa.
Ngati wodwala akudwala matenda a impso, ndiye kuti simuyenera kumwa fluvastatin. Kwambiri zikutsimikizira zovuta za mankhwalawa pazomwe zimagwira impso.

Kuphatikizidwa kwa mitundu ingapo yama statins ndikuloledwa, mwachitsanzo, Atorvastatin + Rosolipt.

Sizowoneka bwino kuphatikiza ma statins ndi nicotinic acid. Zimatha kupangitsa kugwa kwamphamvu mu shuga m'magazi a anthu odwala matenda ashuga, zomwe zimapangitsa kuti magazi azituluka m'mimba.

Statins: mndandanda wa mankhwala ndi mawonekedwe ogwiritsira ntchito

Ma Statin amalembedwa nthawi zambiri. Amathandizanso kuchepetsa kuchuluka kwa cholesterol m'magazi a odwala. Kugwiritsa ntchito kwawo motsutsana ndi matenda a shuga kumakhala koyenera, komabe, zoopsa zonse mu chithunzi china ziyenera kukumbukiridwa. Kutsitsa cholesterol kumachitika chifukwa choletsa mapangidwe ake m'chiwindi.

Statin adayikidwa m'mibadwo. Pali anayi a iwo. Ali ndi zinthu zosiyanasiyana zogwira, zosiyana mu contraindication, mavuto. M'badwo woyamba umaphatikizapo waukulu yogwira pophika simvastatin. Amakhulupirira kuti mankhwala am'badwo uno amaphunziridwa kwambiri, koma samalimbikitsidwa, popeza mapiritsi amphamvu kwambiri adawonekera.

Mapiritsi satchulidwa konse ngati wodwala matenda ashuga ali ndi mbiri ya myopathy kapena ali pachiwopsezo chachikulu chotenga matendawa. Simungathe kutenga mwana akabereka, ndikuyamwitsa, panthawi yowonjezera matenda a chiwindi.

M'badwo woyamba wama statin umaimiridwa ndi mankhwala otsatirawa:

Mankhwala amawoneka ngati ma analogues. Ngakhale mayina osiyanasiyana, ali ndi mfundo imodzi yochitapo kanthu. Mlingo amasankhidwa payekha. Koma mwezi woyamba wa maphunziro achire umaphatikizapo kugwiritsa ntchito 10 mg patsiku. Ngati ndi kotheka, mlingo umakulitsidwa.

Mankhwala a m'badwo wachiwiri amaphatikizanso yogwira fluvastatin. Mwa gulu ili, Leskol Forte nthawi zambiri amalimbikitsidwa. Zotsatira zabwino za mankhwalawa zimawonedwa mu matenda a shuga, chifukwa mapiritsi amachotsa urea mthupi. Kuti mukwaniritse zomwe mukufuna, muyenera kudya.

Gawo lomwe likukhudzidwa ndi mankhwalawa ndi atorvastatin. Zimathandizira kuchepetsa ndende ya otsika osalimba lipoproteins. Malangizowo akuti mapiritsi amatengedwa kamodzi patsiku, kuyambira ndi 10 mg. Mlingo wapamwamba tsiku lililonse ndi 80 mg. Kuchepetsa kwambiri cholesterol, ma statin amatha kuphatikizidwa ndi mankhwala ena, mwachitsanzo, Omacor.

M'badwo wachinayi (wotsiriza) - mankhwala otetezeka kusintha mawonekedwe a cholesterol. Izi zikuphatikizapo Rosart, Rosuvastatin, Krestor. Dziwani kuti ambiri akufuna mankhwala a Novostatin, koma mankhwalawa sapezeka. Itha kuganiziridwa kuti kusaka ndikulinga ku Lovastatin.

Thupi rosuvastatin limaphatikizidwa chifukwa cha tsankho lactose, kuperewera kwa lactase, hypothyroidism, hypersensitivity, kwambiri pathologies mu gawo la kubwezeretsa.

Zimapangira kuti muchepetse mafuta m'thupi

Fibates ndi gulu lopatula la mankhwala omwe amachepetsa kuchuluka kwa LDL chifukwa cha kusintha kwa kapangidwe ka lipid. Nthawi zina, zimaphatikizidwa ndi ma statins kuti muchepetse mavuto, koma izi sizothandiza.

Filates sinafotokozeredwe kwa odwala matenda ashuga ngati ali ndi mbiri yolephera kuyenda bwino kwa chiwindi, matenda owopsa a chiwindi, kuperewera kwaimpso, kapena matenda enaake. Simungathe kumwa mankhwalawa panthawi yapakati, ndikuyamwitsa, hypersensitivity.

Mankhwala ndi omwe anapangidwa, ali ndi zovuta zambiri, motero kugwiritsa ntchito kumayambira ndi mlingo wochepa. Pang'onopang'ono zimawonjezeka pakapita mwezi umodzi. Kuphatikiza apo, mutha kugwiritsa ntchito wowerengeka azitsamba, mwachitsanzo, msuzi wa adyo uli ndi mphamvu yoyeretsa mitsempha yamagazi ndikuyeretsa zolembera za cholesterol.

Oimira gulu la fibrate:

Gemfibrozil - mapiritsi a cholesterol ndiabwino kwambiri, koma osati otsika mtengo. Mtengo ndi ma ruble 1700-2000 phukusi lililonse. The ntchito limapereka kuchepa ndende ya triglycerides, kuchepa kupanga lipids, amene imathandizira kuchotsedwa kwa zoipa mafuta m'thupi. Mutha kugula ku pharmacy kapena kugula pa intaneti,
Bezafibrat ndi chida chomwe chimathandiza kuyeretsa magazi m'magazi a cholesterol plaque. Itha kulembedwa kwa odwala matenda ashuga omwe ali ndi mbiri yamatenda am'mtima komanso angina pectoris. Mtengo kuchokera ku ruble 3000 pa paketi iliyonse.

Etofibrate amachepetsa cholesterol yamagazi, amachepetsa mamasukidwe amwazi, amadziwika ndi katundu wa antithrombotic. Tengani 500 mg mukatha kudya. Poyerekeza ndi chithandizo cha nthawi yayitali, kuwunika momwe ndulu ikufunira.

Mankhwala ena otsitsa cholesterol

Pali kutsutsanabe pakufunika kwa Aspirin kuchokera ku cholesterol yayikulu - akatswiri azachipatala sangathe kudzagwirizana. Ena amaganiza kuti ndi mankhwala otsika mtengo, pafupifupi panacea, amalimbikitsa kutenga nthawi yayitali ngati kupewa atherosulinosis ndi matenda osiyanasiyana amtima.

Madokotala ena samapereka mankhwala, ngakhale mopitilira, amayesa kuletsa mankhwalawa. Palibe mgwirizano. Koma maphunziro azachipatala amawonetsa kuti mapiritsiwa ndi otsika kwambiri, chifukwa chake odwala matenda ashuga sayenera kumwa, pang'ono palokha.

Kuchepetsa cholesterol m'thupi kumafuna njira yolumikizidwa, kotero ma statins ndi ma fiber amatha kuphatikizidwa ndi mankhwala ena.

Chithandizo cha hypercholesterolemia chimaphatikizapo mankhwala:

Probucol ndi mankhwala a hypolipidemic komanso antioxidant omwe amathandizira kutsimikiza kwa LDL mu shuga. Imalepheretsa kupanga cholesterol mthupi la munthu, imathandizira kuchotsedwa kwa zinthu zoyipa m'magazi. Kugwiritsidwa ntchito ndi maphunziro kwa nthawi yayitali,
Alisat ndi chida chotsika mtengo komanso chothandiza komanso chowoneka bwino chochita. Imayendetsa kuthamanga kwa magazi, kutsitsa mamasukidwe amwazi, kutsimikiza kuundana kwa magazi ndi kusungunuka kwama cholesterol. Mapiritsiwo amakhala ndi adyo, ndiye si mankhwala athunthu.

Ndi hypercholesterolemia, mapiritsi amayikidwa kokha ndi dokotala, poganizira kuchuluka koyambirira kwa LDL komanso mkhalidwe wa wodwalayo. Chithandizo cha anthu odwala matenda ashuga chimayendera limodzi ndi zakudya zopatsa thanzi komanso zolimbitsa thupi, zomwe zimakuthandizani kuti mulibe matenda a cholesterol.

About mankhwala ochepetsa cholesterol akufotokozedwa mu kanema m'nkhaniyi.