Sibutramine - Mankhwala a Anorexigenic omwe amachititsa kuti munthu azimva bwino. Ndiopakati pochita serotonin ndi norepinephrine reuptake inhibitor, ofanana kwambiri mumapangidwe amphetamine. Kukonzekera uku ndi kusakaniza mitundu ya (+) ndi (-) enantiomers a 1 - (4-chlorophenyl) -N, N-dimethyl-alpha- (2-methylpropyl) methylamine cyclobutane, formula C17H26ClN, maselo kulemera 279,85 g / mol. Sibutramine ndi amodzi mwa mankhwala omwe amalimbikitsidwa kuti agwiritsidwe ntchito polimbana ndi kukonza mankhwalawa pofuna kuthana ndi kunenepa kwambiri.

Mu 2010, bungwe la Food and Drug Administration la United States of America lidalimbikitsa kuti anthu omwe adakumana ndi vuto lamtima wam'mbuyomu adagwiritsa ntchito mankhwalawa. Ndipo bungwe la Britain Regulatory Agency for Health and Medicines, linati mankhwala aliwonse omwe ali ndi sibutramine amadzetsa mavuto kwa anthu ndi thanzi lawo.

Sibutramine hydrochloride ndi kusankha serotonin ndi norepinephrine reuptake inhibitor ogwiritsidwa ntchito pochiza odwala omwe ali ndi kunenepa kwambiri. Zimathandizira kuchepetsa mafuta ochulukirapo m'thupi, ndiye kuti ndi mankhwala omwe akhala akuchita kwa nthawi yayitali. Sibutramine hydrochloride - tikulimbikitsidwa kugwiritsa ntchito kuwonjezera pa chakudya, momwe kuchuluka kwa zopatsa mphamvu kumachepera.

The thermogenic mphamvu ya Sibutramine imachitika kudzera mwa adrenergic dongosolo, makamaka kudzera mwa kukonzekera kosakhudzika kwa beta-3-adrenergic receptors. Kugwiritsa ntchito mankhwalawa kumawonjezera kwambiri zomwe zili mu thermogenesis mu minofu ya bulauni ya adipose, munthawi imeneyi kutentha kwa thupi kumasintha molingana ndi 1 degree. Koma iyi ndi imodzi mwazinthu zazikulu za clenbuterol, chifukwa chake, kusintha kwa kutentha kwa thupi kukuwonetsa kuti njirayi ikuchitika molondola.

Sibutramine imathandiza pang'onopang'ono, mosasunthika komanso mosamala kuchepetsa kuchuluka kwa mafuta chifukwa cha zinthu ziwiri zofunika. Choyamba, mankhwalawa amathandizira kugwiritsidwa ntchito kwa calorie ndikufulumizitsa kagayidwe. Kachiwiri, sibutramine hydrochloride imachepetsa kwambiri njala. M'maphunzirowa, zidapezeka kuti nthawi yoyamba yomwe mankhwala amatengedwa ndi mlingo wa 10 mg, kagayidwe kake kamakhala bwino ndi 30% ndipo kugwira ntchito kumeneku sikunachepetse kwa maola asanu ndi limodzi, komanso kuchuluka kwa zakudya zomwe zimagwiritsidwa ntchito patsiku zidatsitsidwa mpaka 1300 Kcal.

Maphunziro azachipatala

Mu 2001, mayesero awiri azachipatala odziyimira pawokha adachitika m'maiko osiyanasiyana padziko lapansi.

Yoyamba idachitika ku USA, Kansas, Institute of Clinical Pharmacology. Gulu la anthu lidatenga nawo gawo, lomwe limaphatikizapo anthu 322 amisinkhu yosiyanasiyana, kugonana, komanso kunenepa kosiyanasiyana.

Lachiwiri lidachitika ku China ndi dipatimenti ya Endocrinology. Apa, anthu 120 omwe ali ndi mavuto omwewo adatenga nawo mbali phunziroli.

Zotsatira zamaphunzirowa, zomwe zidatenga masiku 168, mdziko limodzi komanso mayiko ena, odwala omwe adatenga Sibutramine hydrochloride adawonetsa zochitika zabwino pakuchepetsa thupi. Zambiri zolondola zikuwonetsa kuti ku China, kuchuluka kwa thupi komwe kumawerengera maphunziro onse kunali pafupifupi 7 kg panthawiyi, ndipo ku USA, panthawi imodzimodzi, kuchepa kwa thupi kunachokera 5% mpaka 10% ya kulemera koyamba kwa maphunziro.

Zotsatira za pharmacological

Pharmacological kanthu - anorexigenic.Imalepheretsa kubwezeretsanso kwa ma neurotransmitters - serotonin ndi norepinephrine kuchokera ku synaptic cleft, zimatha kuyanjana kwa synergistic pakati pa norepinephrine yapakati ndi kachitidwe ka serotonergic. Sibutramine imachepetsa njala, imachulukitsa thermogeneis (chifukwa chosalunjika pa beta3-adrenergic receptors), imakhudza minofu ya adipose. Amapanga metabolites yogwira ntchito mthupi yomwe imaposa sibutramine hydrochloride mu mphamvu yoletsa kubwezeretsanso kwa serotonin ndi norepinephrine. Ma metabolites omwe amagwira ntchito awa amathanso kubwezeretsanso kwa dopamine, koma amakhala ofooka katatu kuposa 5-HT ndi norepinephrine. Sibutramine sichikhudza kutulutsidwa kwa ma monoamines ndi ntchito ya MAO, sichikugwirizana ndi ma neurotransmitter receptors, kuphatikizapo serotonergic, adrenergic, dopaminergic, benzodiazepine ndi glutamate (NMDA), alibe anticholinergic ndi antihistamine athari, amalepheretsa mapulateni a 5-HT uptake.

Kuchepa kwa thupi chifukwa cha kuchepa kwamafuta kumayendera limodzi ndi kuchepa kwa kuchuluka kwa ma triglycerides, cholesterol, LDL ndi uric acid komanso kuwonjezeka kwa kuchuluka kwa HDL mu seramu. Mukamagwiritsa ntchito mankhwalawa, pamakhala kukwera kwa kuthamanga kwa magazi pakupuma (mwa 1-3 mmHg) ndi kuchuluka kwa mtima (mwa 3-7 kumenyedwa / mphindi), kusintha kotereku kumawoneka ngati kochepa, koma nthawi zina kumakhala kutchulidwa kwambiri. Pankhani yogwiritsira ntchito munthawi yomweyo ma microsomal oxidation inhibitors, kugunda kwa mtima kumawonjezeka (pofika 2,5 bpm) ndipo nthawi ya QT imakulitsidwa (ndi 9.5 ms).

Pakufufuza komwe kunachitika pa makoswe a labotale, komwe kunachitika kwa miyezi yopitilira 24, pogwiritsa ntchito Mlingo womwe unkayang'aniridwa pomwe malo omwe ali munthawi yogwirira ntchito (AUCs) ya 2 metabolites anali okwanira 0,5-21 kuposa amenewo pamene amamwa MRI. Pafupipafupi mapangidwe a chosaopsa chotupa cha tinthu tating'onoting'ono ta testes makamaka m'magazi a mtima wamwamuna ukuwonjezeka. Palibe mankhwala omwe adawonedwa mwa akazi, komanso mbewa za akazi onse. Sichikhudza chonde ndipo sichikhala ndi vuto lokhala ndi mutagenic. Panthawi yoyang'anira Mlingo wa makoswe, ma AUC omwe amagwiritsa ntchito ma metabolites omwe anali okwera ka 43 kuposa omwe amawonetsedwa ndi MRI, panalibe mphamvu yayikulu. Koma pochita kafukufuku pa akalulu pazikhalidwe pomwe AUCs yogwira metabolites ya sibutramine anali okulirapo nthawi 5 kuposa pogwiritsira ntchito MPD. Ana obwera pambuyo pake adawonetsa kusintha pang'ono pa thupi. Mwa ana ena, kusintha kwa kukula kwa mafupawo kudawululidwa ndipo mchira, muzzle ndi auricles zidasintha pang'ono mawonekedwe ndi kukula kwake.

Zotsatira zoyipa

Zotsatira zoyipa zimatha kuchitika m'mwezi woyamba kumwa mankhwalawa, koma pakapita nthawi, mawonekedwe awowonekera ayenera kufooka.

Kwa chimbudzi, kusiya kudya, kudzimbidwa, kumva pakamwa pouma, nseru, komanso kuwonjezeka kwapang'onopang'ono kwa ntchito ya michere ya chiwindi.

Zotsatira za chapakati ndi zotumphukira zamitsempha zimatha kukhala: kugona, kupweteka mutu, chizungulire, nkhawa, kupweteka kwambiri, thukuta, kuwonjezeka kwa kumverera kwakumva, kupweteka kwakanthaŵi. Nkhani yokhayokha idalembedwanso ngati wodwala yemwe ali ndi vuto la matenda a psyizoaffective atayamba kukhala pachimake psychosis.

Zotsatira za mtima wamtima, tachycardia, kuchuluka kwa kuthamanga kwa magazi (kuchuluka pang'ono kwa kuthamanga kwa magazi pakupumula kwa 1-3 mmHg ndi kuwonjezeka pang'ono kwa kugunda kwa mtima ndi 3-7 kumenyedwa / mphindi), vasodilation (khungu limatembenuka kukhala lofiira, akumva kutentha), zotupa zimachepa. Nthawi zina, kuchuluka kwamphamvu kwa kuthamanga kwa magazi ndi kugunda kwa mtima, kumverera kwa palpitations ndikotheka.

Milandu imodzi yacute interstitial nephritis, mesangiocapillary glomerulonephritis mu kwamikodzo dongosolo ndi kotheka.

Kwa dongosolo lozungulira, thrombocytopenia, cholinga cha Shenlein-Genoch chitha kuchitika.

Contraindication

Amatsutsana panthawi yoyembekezera komanso mkaka wa m`mawere, komanso vuto la matenda amisala, matenda a Tourette, matenda amtima, chotupa chamtima, kulephera kwamtima, matenda amitsempha yamagazi, tachycardia, kukomoka kwa magazi, kuvulala kwamitsempha kapena chiwindi. Hyperthyroidism, chosaopsa Prostatic hyperplasia ndi mapangidwe otsalira a mkodzo, pheochromocytoma, glaucoma, anorexia, bulimia, narcotic, mowa kapena rmakologicheskoy kudalira, kunenepa chifukwa organic, utsogoleli munthawi yomweyo kapena kwa masiku 14 pambuyo zoletsa Mao kapena mankhwala ena amene ali ndi zotsatira ochepetsera pa CNS, pamene ntchito mankhwala ena akhoza kuthandiza kuchepetsa thupi, kuchuluka kudziwa hydrochloride sibutramine.

Pafupifupi munthu aliyense wonenepa kwambiri kamodzi kanthawi m'moyo wake amalota piritsi lozizwitsa lomwe lingamupangitse kukhala wochepa thupi komanso wathanzi. Mankhwala amakono abwera ndi mankhwala ambiri omwe amatha kupusitsa m'mimba kuti adye zochepa. Mankhwalawa amaphatikizapo sibutramine. Imayang'aniradi chilakolako cha chakudya, imachepetsa kulakalaka chakudya, koma osati yophweka monga momwe ingaoneke poyamba. M'mayiko ambiri, phindu la sibutramine ndilochepa chifukwa cha zovuta zake.

Sibutramine ndi mankhwala amphamvu. Poyamba, idapangidwa ndikuyesedwa ngati antidepressant, koma asayansi adaona kuti ili ndi mphamvu ya anorexigenic, ndiye kuti imatha kuchepetsa chilakolako cha kudya.

Kuyambira 1997, yakhala ikugwiritsidwa ntchito ku United States ndi mayiko ena ngati njira yabwino yochepetsera thupi, kupereka kwa anthu odwala matenda osiyanasiyana. Zotsatira zoyipa sizinatenge nthawi.

Zinapezeka kuti sibutramine ndiwosuta komanso wokhumudwitsa, womwe ungafanane ndi mankhwala. Kuphatikiza apo, adakulitsa chiwopsezo cha matenda amtima, anthu ambiri adadwala stroko komanso mtima pamene adatenga. Pali umboni wosagwirizana wosonyeza kuti kugwiritsa ntchito sibutramine kunayambitsa kufa kwa odwala.

Pakadali pano, ndizoletsedwa kuti zigwiritsidwe ntchito m'maiko ambiri, ku Russian Federation kutulutsidwa kwawo kumalamulidwa mosamala kugwiritsa ntchito mitundu yapadera yomwe zalembedwa.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amangoperekedwa ndi adotolo ndipo pokhapokha ngati njira zotetezeka sizibweretsa zotsatira zowoneka:

• Kunenepa kwambiri. Izi zikutanthauza kuti vuto la kunenepa kwambiri lidayamba chifukwa cha zakudya zopanda pake komanso kusachita masewera olimbitsa thupi. Mwanjira ina, kuti zopatsa mphamvu zikamalowa m'thupi kwambiri kuposa momwe amawonongera. Sibutramine amathandizira pokhapokha index boima wa thupi ukadutsa 30 kg / m 2.
• Kunenepa kwambiri kuphatikiza matenda a shuga a 2. BMI iyenera kukhala yoposa 27 kg / m 2.

Njira yogwiritsira ntchito

Mlingo amasankhidwa ndi adokotala pokhapokha ataganizira mosamala zoopsa zonse ndi mapindu ake. Palibe chifukwa muyenera kumwa nokha mankhwalawo! Kuphatikiza apo, sibutramine imachotsedwa pamafakisoni mosamalitsa monga mankhwala!

Imakhazikitsidwa nthawi 1 patsiku, makamaka m'mawa. Mlingo woyambirira wa mankhwalawa ndi 10 mg koma, ngati munthu salekerera bwino, amachepetsa mpaka 5 mg. Kapepalako kamayenera kutsukidwa ndi kapu ya madzi oyera, pomwe sikulimbikitsidwa kutafuna ndi kutsanulira zomwe zili pachilombacho. Mutha kumwa zonse pamimba yopanda kanthu komanso nthawi yam'mawa.

Ngati mwezi woyamba kusintha kwa thupi sizinachitike, mulingo wa sibutramine ukuwonjezeka mpaka 15 mg.Mankhwalawa nthawi zonse amaphatikizidwa ndi masewera olimbitsa thupi komanso zakudya zapadera, zomwe zimasankhidwa payekha kwa munthu aliyense ndi dokotala wodziwa bwino.

Kuchita ndi mankhwala ena

Musanatenge sibutramine, muyenera kukambirana ndi dokotala mankhwala onse omwe amamwa mosalekeza. Si mankhwala onse omwe amaphatikizidwa ndi sibutramine:

1. Mankhwala osakanikirana omwe ali ndi ephedrine, pseudoephedrine, etc., achulukitsa kuchuluka kwa kuthamanga kwa magazi ndi kugunda kwa mtima.
2. Mankhwala omwe akukhudzidwa ndikuwonjezera serotonin m'magazi, monga mankhwala ochizira kukhumudwa, anti-migraine, painkillers, narcotic zinthu zina zomwe zimachitika kawirikawiri zimayambitsa "serotonin syndrome." Amwalira.
3. Maantibayotiki ena (gulu la macrolide), phenobarbital, carbamazepine imathandizira kusweka ndi kuperewera kwa sibutramine.
4. Osiyana ma antifungals (ketoconazole), immunosuppressants (cyclosporin), erythromycin amatha kukulitsa kuchuluka kwa sibutramine womata komanso kuwonjezereka kwa ma contract a mtima.

Kuphatikizidwa kwa mowa ndi mankhwalawa sikukuwononga thupi molingana ndi kuperewera kwawo, koma zakumwa zoledzeretsa ndizoletsedwa kwa iwo omwe amatsatira zakudya zapadera ndikufuna kuchepetsa thupi.

Chifukwa chiyani sibutramine ndi oletsedwa komanso owopsa

Kuyambira 2010, chinthuchi chakhala choletsedwa kuti chigawidwe m'maiko angapo: USA, Australia, mayiko ambiri aku Europe, Canada. Ku Russia, kutulutsa kwake kumayendetsedwa mosamalitsa ndi mabungwe aboma. Mankhwala atha kutumizidwa pokhapokha ngati akupereka mankhwala ndi zisindikizo zonse zofunika. Ndizosatheka kugula izo movomerezeka popanda mankhwala.

Sibutramine anali oletsedwa ku India, China, New Zealand. Kuletsa, adatsogolera zotsatira zoyipa zomwe zimafanana ndi "kusiya" kuchokera ku mankhwala osokoneza bongo: kusowa tulo, nkhawa mwadzidzidzi, mkhalidwe wokulira wa nkhawa komanso malingaliro odzipha. Anthu ambiri adasinthiratu poyerekeza ndi momwe amagwiritsidwira ntchito. Odwala ambiri omwe ali ndi vuto lamtima wamtima wamwalira ndi matenda a mtima ndi stroko.

Kwa anthu omwe ali ndi vuto lamaganizidwe, iye amaletsedwa kulandira! Ambiri anali atorexia ndi bulimia, anali oganiza kwambiri komanso osintha. Mankhwalawa samangoletsa chidwi chofuna kudya, komanso amakhudza mutu.

Sibutramine pa nthawi yoyembekezera

Amayi omwe adalandira mankhwala awa ayenera kudziwitsidwa kuti palibe chidziwitso chokwanira chokhudza chitetezo cha sibutramine kwa mwana wosabadwa. Zofananira zonse za mankhwalawa zimathetsedwa ngakhale pa gawo lokonzekera kubereka.

Pa mankhwala, mayi ayenera kugwiritsa ntchito njira zolerera komanso zodalirika. Ndi kuyesa kwabwino kwamimba, muyenera kumadziwitsa dokotala wanu ndikusiya kugwiritsa ntchito sibutramine.

Kuphunzira mwalamulo kwa mankhwala

Siputramine woyamba wa mankhwala osokoneza bongo (Meridia) adatulutsidwa ndi kampani yaku Germany. Mu 1997, idaloledwa kugwiritsidwa ntchito ku United States, ndipo mu 1999 ku European Union. Kuti zitsimikizire kugwira bwino kwake, maphunziro ambiri adatchulidwa, momwe anthu opitilira 20,000 adatenga nawo gawo, zotsatirapo zake zinali zabwino.

Pakupita kwa nthawi, anthu anayamba kufa, koma mankhwalawo sanachedwe kuletsa.

Mu 2002, zidaganiziridwa kuchititsa kafukufuku wa SCout kuti awone omwe magulu omwe ali pachiwopsezo cha zotsatira zoyipa ali apamwamba kwambiri. Kuyesera uku kunali kofufuza kawiri-kawiri, koyendetsedwa ndi malo. Mayiko 17 adatenga nawo gawo. Tidaphunzira ubale womwe ulipo pakati pa kuchepetsa thupi munthawi ya mankhwala ndi sibutramine komanso mavuto ndi mtima.

Pakutha kwa 2009, zotsatira zoyambirira zidalengezedwa:

• Kuchitidwa kwa nthawi yayitali ndi Meridia mwa anthu okalamba onenepa kwambiri ndipo ali kale ndi mavuto a mtima ndi mitsempha yamagazi achulukitsa chiopsezo cha matenda amtima ndi mikwingwirima ndi 16% . Koma imfa sizinalembedwe.
• Panalibe kusiyana pakati pa gulu lomwe linalandira "placebo" ndi gulu lalikulu pakafa.

Zinadziwika kuti anthu omwe ali ndi matenda amtima ali pachiwopsezo chachikulu kuposa wina aliyense. Koma sizinali zotheka kudziwa kuti ndi magulu ati omwe odwala omwe angamwe mankhwalawo atayika pang'ono.

Mu 2010 pokhapokha, malangizo omwe adaperekedwa anali okalamba (zaka 65) monga kuphwanya malamulo, komanso: tachycardia, kulephera kwa mtima, matenda amitsempha, etc. Pa Okutobala 8, 2010, wopanga anakumbukira mwakufuna kwake mankhwala omwe amapezeka pamsika wamankhwala mpaka zonse zitamveka bwino. .

Kampaniyi idakali kuyembekezera maphunziro owonjezera, omwe akuwonetsa kuti ndi magulu ati a odwala omwe mankhwalawa amabweretsa zabwino zambiri ndikuvulaza pang'ono.

Mu 2011-2012, Russia idachita kafukufuku wawo, dzina lake "VESNA". Zotsatira zosafunikira zidalembedwa mu 2.8% ya odzipereka; palibe zoyipa zambiri zomwe zingafune kuti sibutramine ichiritsidwe. Anthu opitilira 34,000 azaka za 18 mpaka 60 adatenga nawo gawo. Iwo adatenga Reduxin wa mankhwala osokoneza bongo kwa miyezi isanu ndi umodzi.

Kuyambira 2012, kafukufuku wachiwiri wachitika - "PrimaVera", kusiyana kwake kunali nthawi yogwiritsa ntchito mankhwalawa - kuposa miyezi 6 yothandizira mosalekeza.

Kuwongolera Analogs

Sibutramine imapezeka pansi pa mayina awa:

• Golidi
• Goldline Plus,
• Reduxin
• Reduxin Met,
• Slimia
• Lindax,
• Meridia (kulembetsa kale kubwezeretsedwa).

Ena mwa mankhwalawa ali ndi kuphatikizika. Mwachitsanzo, Goldline Plus imaphatikizanso ma cellcose a microcrystalline, ndipo Reduxin Met imakhala ndi mankhwala 2 nthawi imodzi - sibutramine pamodzi ndi MCC, m'matumba osiyanasiyana - metformin (njira yochepetsera misempha ya shuga).

Nthawi yomweyo, Kuwala kwa Reduxine kulibe sibutramine konse, ndipo ngakhale ndi mankhwala.

Aliyense wonenepa kwambiri amafuna kuchepetsa thupi msanga komanso osafuna kuchita masewera olimbitsa thupi. Ambiri amayamba kuphunzira zambiri zokhudzana ndi mankhwala kuti achepetse thupi. Maziko a ambiri a iwo ndi mankhwala a sibutramine - mankhwala ena apakati omwe amachepetsa njala ndikuyambitsa kagayidwe.

Kuchepetsa thupi ndi mapiritsi apadera kapena tiyi, ma ufa kapena ma cocktail ndi bizinesi yopindulitsa kwambiri. Mankhwala ambiri ochepetsa thupi amakhala ndi okodzetsa, okomoka, ndipo ena amakhudza mwachindunji ubongo ndi malo ake, kupondereza njala ndikuyambitsa kagayidwe.

Chimodzi mwazinthu "zozizwitsa izi" ndi sibutramine - chinthu cholimba chapakati chokhala ndi psychotropic. Chifukwa cha momwe zimakhudzira, kuchepa thupi kumadziwika kwambiri, koma kuchepa thupi kumatha kukhala koopsa.

Sibutramine ndi chinthu chomwe chinapangidwa poyambira antidepressant, koma sichinawonetsedwe kuti chimagwira ntchito kwambiri. Komabe, adawonetsa chochitika china chogwira ntchito kwambiri - adachepetsa kumverera kwanjala, pogawana magawo a oyimira pakati apadera mu ubongo - serotonin ndi norepinephrine. Nthawi yomweyo, panali kuchepa kwa chakudya ndi kuchuluka komweko kwakanema kagayidwe ndi mafuta owonjezera.

Sibutramine ndi gawo la mankhwala ambiri ochepetsa thupi. Zikuwoneka ngati chida chabwino kwambiri, koma maphunziro owonjezereka a zinthuzi ku America adapangitsa kuti sibutramine aletsedwe kotheratu kuti asagulitsidwe ndikugwiritsa ntchito ngati njira yochepetsera thupi.

Sibutramine: Zowopsa

Kufalikira kwa sibutramine ku America ndi ku Europe, pali umboni wowonjezereka woti kumwa mapiritsi azakudya chifukwa chodwala kumabweretsa chiwonjezeke chachikulu cha milandu yodzipha, kugunda kwa mtima ndi stroko, ogula ambiri "adakhala" pa sibutramine.

Opanga izi adakakamiza kufufuza kwathunthu sibutramine ndi kuletsa kugulitsidwa, ndikuti sibutramine ndi gulu la oopsa omwe amafanana ndi mankhwala wamba.

M'malamulo aku Russia, sibutramine ndi zofananira zake amaperekedwa ku gulu lamankhwala amphamvu ndipo saloledwa kuzigulitsa popanda mankhwala apadera a dokotala. Kupatulako ndi milandu ya kunenepa kwambiri komanso kulephera kugwiritsa ntchito njira zina, zopweteketsa kuchepetsa thupi.

Kwa yemwe sibutramine adalumikizidwa

Mu zochuluka zazambiri zamankhwala omwe ali ndi sibutramine, palibe zomwe zikuwonetsa (kapena ndizochepa komanso zosakwanira) za zoyipa ndi zotsutsana. Opanga amawabisira, chifukwa izi zingakhudze kwambiri kugulitsa kwa mankhwala omwe ali ndi sibutramine.

Komabe, mndandanda wa contraindication ndiwambiri kwambiri. Izi zikuphatikiza:

• matenda a mtima ndi mtima (matenda oopsa, matenda a mtima, matenda a mtima),
• ngozi yamatenda,
• matenda amisala ndi mitsempha ndi bulimia kapena anorexia,
• chiwindi kapena matenda a impso
• kuvala zovuta
• matenda a maso (glaucoma, myopia),
• khunyu, kupweteka kwa matenda.

Kuphatikiza apo, sibutramine amaletsedwa kugwiritsa ntchito limodzi ndi mankhwala ambiri - mankhwala ochizira matenda amanjenje, maantibayotiki, mankhwala omwe amakhudza magazi.

Mankhwalawa sagwirizana ndi zakumwa zoledzeretsa, amaletsedwa kumwa mankhwalawa panthawi yokhala ndi pakati komanso zaka zapakati pa 60. Ndipo malire ndi zoletsa sizimathera pamenepo.

Sibutramine: zotsatira zoyipa

Pambuyo potenga sibutramine, pamakhala zotsatirapo zoyipa zingapo. Choyamba, kumwa mankhwala pogwiritsa ntchito mankhwalawa kumapereka malingaliro ofanana ndi kudalira. Mukaletsa kutha kuchitika:

• kugona komwe kumachitika monga kumachitika.
• kusakwiya, chizolowezi chofuna kudzipha,
• chizungulire, kupweteka mutu,
• kupsinjika kumapitilira, kufooka.

Milandu yayikulu kwambiri, kusanza ndi kusanza, kutupa, kupweteka pachifuwa, kuwona kwamaso, ululu wammbuyo, kuvuta kupuma, kusokoneza, kugaya chakudya, kukanika, kugona, kugona, mavuto obwera ndi khungu.

Ndipo izi sizotsatira zoyipa zilizonse za kutenga sibutramine. Chosafunikanso ndichakuti pakuyesa nyama, chidziwitso chopanga cha sibutramine chinapezeka, ndikuyambitsa kusokonezeka kwa fetal.

Makina a sibutramine ali motere:

• amachepetsa kufunika kwa chakudya,
• imapereka malingaliro okhutira ndikuchepetsa chiopsezo cha kusokonekera kwa chakudya,
• zimayambitsa kagayidwe kachakudya
• amalimbikitsa kutentha kwa mafuta ozama,
• imalimbikitsa kuchotsedwa kwa zinthu zowola.

Kukonzekera kwa Sibutramine

• Meridia ndi mankhwala achijeremani ochepetsa thupi komanso kusintha mtundu wa psychoemotional. Amagwiritsidwa ntchito muyezo wocheperako, koma amafuna nthawi yayitali. Ili ndi mndandanda wochititsa chidwi wa zotsutsana ndi zoyipa. Amawerengera zochitika zam'magazi zomwe zimayikidwa pachiwopsezo cha moyo wa wodwalayo,
• "Lindaksa" - cholinga chake ndi kuchepetsa kudalira chakudya, cholimbikitsidwa kuti chizigwiritsidwa ntchito kukonza zakudya pakakhala kosatheka kupewera njala ndi njira zina. Malinga ndi omwe akupanga, mankhwalawa siwosokoneza bongo komanso samadalira, komabe, madokotala salimbikitsa kugwiritsa ntchito mankhwalawa kwa nthawi yayitali,
• "Slimia" - imakuthandizani kuti muchepetse kuchepa kwa thupi, kuthamangitsa metabolidi ya lipid, kumachotsa kudalira kwa chakudya,
• "Goldline ndi mankhwala okhala ndi sibutramine wambiri. Yopangidwa ndi kampani yaku India. Amagwiritsidwa ntchito pochiza kunenepa kwambiri, amakhudzanso dongosolo lamkati lamanjenje, kugwiritsidwa ntchito kwambiri kumayambitsa kudalira,
• "Obestat" ndi mankhwala othandizira kukhazikika ndi kukonza machitidwe azakudya.Monga mankhwala ena onse opangidwa ndi sibutramine omwe amagulitsidwa ndi mankhwala, amagwiritsidwa ntchito pokhapokha pochiza kunenepa kwambiri.

Kwa omwe ndalamazo zaletsedwa

Mankhwala okhala ndi Sibutramine ali ndi mndandanda wochititsa chidwi wa zotsutsana zazikulu. Zomwe zikuluzikulu ndizophwanya ntchito ya mtima, chiwindi ndi impso, chifukwa chinthucho chimapanga katundu pazonsezi.

Zowonongeka zamankhwala ndizofunika kwambiri ngati kunenepa kwambiri sikunachokera kwa alimentary, koma kwachiwiri. Nthawi zambiri, mavuto a kagayidwe kachakudya ndi ntchito ya ziwalo zamkati zimayambitsa. Zochita zamankhwala zimatsimikizira kusakwanira kwa sibutramine muzochitika zotere. Zotsatira zina zotsutsana ndi mankhwalawa:

• osakwana zaka 18
• patatha zaka 65
• ndi bulimia,
• ndi matenda a anorexia,
• mavuto amisala
• Mafunso
• hyperthyroidism
• ochepa matenda oopsa
• Prostate adenoma
• glaucoma
• kugwiritsa ntchito mankhwala osokoneza bongo
• kudalira mankhwala
• uchidakwa.

Kusamalira makamaka kumafuna kuikidwa kwa sibutramine ku khunyu ndipo anthu amakonda kukomoka, komanso omwe ali ndi vuto la hematopoiesis kapena magazi.

Chithandizo chisanachitike, nthawi yapakati komanso yapakati

Nthawi zina kunenepa kwambiri kumayambitsa vuto la kusakhazikika kwa mahomoni mwa akazi, kumalepheretsa kutenga pakati, kutenga pakati komanso kubereka kwa mwana wathanzi. Vutoli likufunika kuti pakhale chithandizo chamankhwala komanso chamankhwala. Ngati njira zina zolembetsera kulemera sizothandiza, sibutramine imatha kutumikiridwa musanabadwe.

Nthawi yonse ya chithandizo, mkazi ayenera kupereka njira zodalirika zakulera. Kuchokera kumapeto kwa njira ya mankhwalawa mpaka nthawi yomwe mayi atatenga pathupi, miyezi iwiri iyenera kudutsa. Nthawi imeneyi, thupi limachotsa zotsalira za mankhwala. Kuchiza ndi mankhwalawa panthawi yoyembekezera komanso yoyamwitsa ndizoletsedwa.

Njira yamachitidwe

Sibutramine imathandizira kumasulidwa kwa serotonin, yomwe imakhudza maonekedwe akumva kufinya msanga, chifukwa chofunitsitsa chakudya chamafuta amachepetsa. Nthawi yomweyo, mafuta owonjezera pamthupi amawotchedwa mwachangu ndipo mapaundi owonjezera amapita.

Mankhwalawa adapangidwa zaka 25 zapitazo ndipo adakhazikitsidwa kwa odwala omwe ali ndi nkhawa kuti akhale bwino.

Zotsatira zake, "Sibutramine" idayamba kugwiritsidwa ntchito kuthana ndi kunenepa kwambiri, ndikuyipereka kwa anthu ngati njira yanjala. Chipangizochi chithandiza anthu omwe akulemera kapena akulephera kuchepera thupi chifukwa chakudya kwambiri.

Munthu amene amamwa mankhwalawa chifukwa cha njala amayamba kuzindikira kuti wataya mtima. Zigawo zikucheperachepera nthawi iliyonse.

Koma osati kuchuluka kwa chakudya chomwe amadya kumakhudza kuchuluka kwa makilogalamu owonjezera, komanso machitidwe ena omwe Sibutramine amayambitsa:

• kuchuluka kwa kuthamanga kwa magazi,
• kutentha kuwonjezeka
• kugunda kwa mtima
• thukuta
• ludzu.

Kuchulukitsa kwa kuthamanga kwa magazi ndi kukoka zimayambitsa kupanga kwa adrenaline - munthu amakhala ndi nkhawa, ngakhale mantha. Adrenaline amawotcha mafuta amthupi mokwanira, ndikuchulukitsa njira yochepetsera kunenepa. Chifukwa cha kuchuluka kwa kutentha, munthu amatuluka thukuta kwambiri, njira za metabolic zimathandizira kwambiri! Njala imakupatsani mwayi kuti mumwe madzi ambiri, ndipo izi zimathandizira kwambiri kagayidwe.

"Sibutramine" kapena fanizo lake limafotokozedwa ndi akatswiri azakudya zamagetsi kapena amisala kwa anthu omwe ali ndi vuto la kunenepa kwambiri komanso omwe ali ndi vuto lakudya. Nthawi zambiri kuikidwa kumachitika ngati njira zina zochepetsera thupi zatha. Sibutramine amachita pakhungu lotsatira:

• Imaletsa kugwidwa kwa ma neurotransmitter serotonin,
• imaletsa kugwidwa kwa neurotransmitter norepinephrine,
• Kuchepetsa kwambiri zomwe zimalepheretsa kupezeka kwa dopamine.

Kuphwanya zakumwa ndi kusinthana kwa oyimira pakati pakatikati wamanjenje kumabweretsa chitukuko chofanana cha ziwalo zonse. Zotsatira za kutenga sibutramine ndi izi:

• kulakalaka - kumva kudwala kwa wodwala kumachepa kwambiri, sangathe kuzimva, ngakhale pakanalibe chakudya chimodzi patsiku,
• kagayidwe - chifukwa cha kamvekedwe ka mtima, kusintha kwa kutentha kumawonjezeka, thupi limakakamizidwa kuti ligwiritse ntchito mphamvu zambiri, pogwiritsa ntchito nkhokwe zake kuchokera ku depos,
• kutentha kwa mafuta - kutengera zomwe zidachitika kale, chifukwa mphamvu zakunja zimachepa,
• kukomoka - chifukwa cha kudya, chidwi cha wodwalayo chimachitika nthawi yomweyo chakudya chikayamba.

Kusintha kambiri mu ntchito ya ubongo komwe kumakhudzidwa ndi kugwiritsa ntchito sibutramine kumathandizira kuchepetsa kunenepa kwambiri pamlingo wonse: mwakuthupi, mwamaganizidwe, m'thupi. Chimodzi mwa mankhwalawa ndikutha kulimbikitsa kuwotcha "mafuta a bulauni".

Ngakhale izi ndizomwe zimapangidwira yaying'ono mthupi la munthu, zimagwira gawo lofunikira kwambiri pakuwonjezera kutentha. Ndipo kugawanika kwawo kumayambitsa kudyedwa kwa "mafuta oyera", owonjezera omwe amatsatira kunenepa kwambiri.

Mankhwala osokoneza bongo omwe amakhudza gawo lamanjenje amatha kuchepetsa ntchito zamaganizidwe, kukumbukira, komanso momwe angachitire. Ngakhale sibutramine sizinakhudze izi mu maphunziro, komabe, kutenga Meridia® kumatha kuchepetsa kuyendetsa magalimoto ndi kayendedwe kazinthu.

Munthawi ya chithandizo, chisamaliro chikuyenera kuchitika poyendetsa magalimoto ndi kuchita zina zomwe zingakhale zoopsa zomwe zimafuna kuti anthu azisamalira komanso azithamanga kwambiri.

Kutenga Reduxin ® kumatha kulepheretsa wodwala kuyendetsa magalimoto ndi makina.

• Ili ndi zotumphukira
• Makina ochitapo kanthu ali ofanana ndi chikhalidwe cha triglycerides pamene mamolekyu a chapamimba ndi pancreatic lipase amamangirira, osawalola kuyanjana ndi lipids. Mwanjira ina, ma enzyme a m'mimba mothandizidwa ndi orlistat sangathe "kupukusa" mafuta mokwanira, omwe amachotsedwa m'thupi mwachilengedwe (kutanthauza ndi ndowe) panthawi yonse yagaya m'mimba m'matumbo (m'mimba).
• Thupi silimamwa kuchokera m'matumbo am'mimba, i.e. sikulowa mthupi (zambiri zimachotsedwa pakatha masiku 3 - 5, ndipo pafupifupi 2% zimachotsedwa kudzera mu impso)
• Lowers LDL (Low Density Lipoproteins)
• Kuchulukitsa HDL (Kachulukidwe Kwakukulu)
• Kutsitsa magazi (kuthamanga kwa magazi)
• Imachepetsa kusala
• Amagwiritsidwa ntchito pochiza, ndipo chifukwa ndi izi chipukuta cha carbohydrate metabolism chitha kupezeka
• Mlingo Wovomerezeka: kapisozi 1 (120 mg) katatu katatu tsiku lililonse

• Fumbi, mafuta okumbika
• Kutaya kwamafuta
• Fecal kulephera
• Amachepetsa mayamwidwe a mavitamini osungunuka (multivitamin ula)

• Ili ndi tanthauzo lapakati
• Ndi anorexigenic yomwe imachepetsa chilimbikitso (pambuyo pake munthu amayamba kudya zakudya zochepa)
• Imawonjezera kumverera kwodzaza
• Kuchulukitsa kutentha kwa thupi (kumawonjezera kutentha kwa thupi)
• Kuchulukitsa HDL
• Amachepetsa LDL, triglycerides, cholesterol yathunthu, uric acid
• Kuchulukitsa kuthamanga kwa magazi ndikuthamanga kugunda kwa mtima, nthawi zina pamlingo waukulu ("kunama" kukuwoneka)
• Olowetsedwa m'thupi ndi 77%
• Kutalika kwake kwakukulu kumachitika patatha maola 1.2 mutamwa mankhwalawa
• Ntchito mankhwalawa kunenepa kwambiri ndi BMI ya 30 kg / m 2 kapena kupitilira kapena BMI ya 27 kg / m 2
• Zingasokoneze kugwira ntchito kwa magazi

• Kusowa tulo
• Mutu
• Chizungulire
• Kusakwiya
• Kuda nkhawa
• Paresthesia (kusokonezeka kwamalingaliro amthupi osiyanasiyana)
• Kusintha kwamakomedwe
• Pachimake psychosis ndi kulanda paokha
• Tachycardia
• Zosangalatsa pamtima
• Kuchuluka kwa kuthamanga kwa magazi
• Opaleshoni (khungu la khungu lotengeka ndi kutentha)
• Shenlein-Genoch matenda ndi thrombocytopenia mwaokha
• Pakamwa pakamwa
• Kuchepetsa chidwi
• Kudzimbidwa
• Kutsegula m'mimba
• Kuchepetsa mseru
• Kuchulukitsa kwa zotupa m'mimba

Mwanjira ina, chinthu ichi chimakhudza mbali zonse zamkati zamanjenje ndi mtima. Chifukwa chake, singagwiritsidwe ntchito molumikizana ndi mankhwala ena omwe amagwira ntchito pamitsempha yamafupa (antidepressants, antipsychotic, tryptophanes). Imawonjezera katundu pachiwindi ndi impso, chifukwa imagwidwa ndikulowa mthupi kudzera m'mimba.

Ngakhale izi, kugwiritsidwa ntchito kwakutali kwakuloledwa chaka chimodzi!

Ndemanga za akatswiri azakudya zokhudzana ndi mapiritsi

Pakadali pano, sibutramine mu mankhwalawa amalembedwa pa 10 ndi 15 mg. Panthawi yoyesa mankhwala, mankhwalawa amagwiritsidwa ntchito omwe anali apamwamba kwambiri kuposa mlingo wapano. Zotsatira zake - kuchepetsa thupi kunali kosavuta komanso mwachangu.

Sibutramine inayamba kukhala yogwira pothana ndi kuchuluka kwa thupi, pomwe mndandanda wamankhwala wambiri unapita pazaka 30. Kugwiritsa ntchito milingo yayikulu kumayendera limodzi ndi zovuta zingapo, kuphatikizapo:

• kugwidwa mtima
• kutentha kwa mtima
• zotupa za m'mimba,
• kupweteka kwa migraine
• mavuto amisala.

Chifukwa chake, panthawiyo sakanatha kuyambitsa mankhwalawo kuti azigwiritsidwa ntchito kwambiri. Atapeza njira zochepa zochizira, asayansi adapeza zabwino pakuchepetsa mavuto, zomwe zidapangitsa kutilembetsere mankhwala ngati mankhwala ochizira kunenepa.

Malinga ndi akatswiri otsogolera zakudya, Sibutramin ndi chinthu champhamvu kwambiri, chochepetsa thupi. Koma akatswiri samalimbikitsa mankhwalawo panthawi yomwe mukufuna kuchotsa mapaundi owonjezera ochepa, ndipo sitikulankhula za kunenepa kwambiri.

Nutritionists amalingalira kuti kutembenukira ku chinthu champhamvu sibutramine hydrochloride monohydrate ndizotheka pokhapokha pangozi ya moyo wa munthu chifukwa cha kunenepa kwambiri. Malinga ndi madotolo, anthu omwe amafa ndi matenda omwe amayamba chifukwa chokhala onenepa kwambiri amatsitsidwa mpaka 40%, mukangotsitsa 10% yokha ya owonjezera!

Mankhwala, Sibutraminum imagwiritsidwa ntchito ngati mchere - hydrochloride monohydrate. Sibutramine monohydrate ufa, wokutira mumipu ya pulasitiki kapena matumba apulasitiki okhala ndi magawo awiri a 0.1-2.5 makilogalamu, amapangidwa ndi makampani azachipatala a Symed Labs (India), Izvarino-Pharma (Russia), Shanghai Modern Pharmaceutical (China).

Amawagawa m'malo azachipatala ndipo amagwiritsidwa ntchito ngati zopangira popanga mankhwala omwe amalimbikitsa kulakalaka. M'mafakitala, mankhwala omwe ali ndi sibutramine amawerengedwa pokhapokha kuchokera kwa endocrinologist kapena wathanzi.

Mankhwalawa, omwe akuphatikizapo Sibutramine
ndi microcellulose
wotchedwa.

Sibutramine sikuti amangochotsa mapaundi owonjezera, komanso samalola kuti aziyimilira pazatsopano, zomwe zimatsimikizira mgwirizano wazitali. Pazomwe mungagwiritse ntchito kuti muchepetse kunenepa, phunzirani kuchokera m'nkhaniyi.

Ngakhale zaka 10-15 zapitazo ku Russia, kuchuluka kwa anthu onenepa kwambiri kunkakhala kwakukulu kwambiri ku Europe. Masiku ano, Russia ili mu TOP 5 mwa mayiko “olemera kwambiri” padziko lapansi, ndipo yachiwiri ndi USA, China, India ndi Brazil pamulingo uwu.

Kulemera kwambiri kumachitika mwa kukulitsa kuchuluka kwa minofu ya adipose, yomwe nthawi zambiri imayikidwa m'malo "wamba" - m'chiuno, pamimba, m'chiuno, kumbuyo. Kunenepa kwambiri kumayambitsa kusokonezeka kwa m'maganizo komanso thupi, koma vuto lake lalikulu ndi chiopsezo chowonjezereka cha matenda oopsa, matenda a m'matenda am'mimba, matenda a shuga, komanso matenda a minofu.

Ndizotheka kuti nthawi zonse musataye kuchuluka kwama kilogalamu owonjezera omwe ali ndi gawo limodzi la kotala ya thupi mothandizidwa ndi zowonjezera zakudya, zakudya, kapena masewera olimbitsa thupi, nthawi zambiri mumayenera kusintha "zojambula zolemera" - mankhwala osokoneza bongo.

Mankhwala omwe amathandizidwa kuti muchepetse kunenepa ndi osiyanasiyana malinga ndi mfundo yochitira: ena amalimbitsa mtima pakudya, ena amachepetsa kuthira kwa mafuta ndi michere, ndipo ena, atakhala ndi vuto lotupa, osalola chakudya kugayidwa.

Koma popeza mankhwalawa ali ndi mphamvu, amatha kupereka zovuta zoyipa ndikulakwira zambiri. Amalembera mitundu yayikulu ya kunenepa, pamene njira zina zamankhwala sizothandiza. Sibutramine ndi mankhwala amphamvu pochiza kunenepa kwambiri.

Meridia

Sibutramine - malangizo, ntchito, malingaliro, madokotala komanso kuchepetsa thupi. Mankhwala onenepa kwambiri (Orlistat, Sibutramine ndi mayendedwe awo)

Atsikana amakono amakonda kuchepa thupi komanso kukhala ndi chiuno chochepa. Kupita ku cholinga ichi sikophweka, koma mankhwala osiyanasiyana ndi othandiza kwambiri pankhani yotere. Ndemanga yakuchepera "Sibutramine" imatsutsa kuti mapiritsiwa ndi othandizadi. Chida ichi chimathandizira kuchepetsa thupi mwachangu, koma pokhapokha potsatira malamulo ogwiritsa ntchito ndi kuwasunga.

Pakumva zakugwiritsa ntchito bwino kwa mankhwalawa, anthu ali ndi chidwi ndi malangizo ndikuwunika pa "Sibutramine." M'malo mwake, zimasiyana ndi omwe amapikisana nawo pazinthu zina zomwe zimawonetsedwa ndikugwiritsa ntchito. Ngati simutsatira malamulowo, musayerekeze kuchita zabwino, koma utha kuwononga thanzi lanu m'njira imeneyi mwachangu.

M'nkhaniyi mutha kudziwa zambiri za mankhwalawa. Mndandanda wa Sibutramina, malangizo ogwiritsira ntchito ndi kuwunikira - zonsezi zitha kukhala zothandiza kwa amayi ndi abambo omwe sakhutira ndi mawonekedwe awo.

Kugwiritsa

Ndemanga pa malangizo a Sibutramina ndi abwino. Nthawi zambiri, anthu amawonetsa kuti palibe chomwe chimavuta pakumwa mapiritsi, kotero kupeza nthawi ndi mlingo sichovuta. Mankhwala ndi mankhwala osachepera 10 mg pa tsiku. Ngati kulemera kumachoka pang'onopang'ono, mavuto sanatchulidwe, mankhwalawa akhoza kuwonjezeka mpaka 15 mg. Ndipo ngakhale zitakhala kuti zoterezi zimapangitsa kuti mapaundi owonjezera asachokere mwachangu, ndiye kuti sizingakhale zopanda phindu kwa mankhwalawa, ndiye kuti zitha.

Ndemanga zambiri za malangizo ogwiritsira ntchito "Sibutramine" zikuwonetsa kuti kumwa mankhwalawa ndikofunikira kwa nthawi yoposa chaka. Mutha kuletsa kugwiritsa ntchito pokhapokha ngati, m'miyezi itatu yoyambirira, sizinali zotheka kuti muchepetse kuchuluka kwa thupi, komanso muzochitikazo pamene mankhwalawa amayamba kuchuluka.

Anthu amatembenukira ku Sibutramin pomwe palibe njira yowathandizira kuti achepetse thupi. Potere, mankhwalawa amachitika mokwanira. Zimaphatikizapo osati kusintha kwa zakudya, komanso kuwonjezera kwa zolimbitsa thupi. Chifukwa cha kusintha kwa moyo wamasiku onse, womwe umapangitsa kunenepa kwambiri, zotsatira zake zimachedwetsedwa kwa nthawi yayitali.

Panthawi yamankhwala, ndikofunikira kuwongolera kuthamanga kwa magazi anu, komanso kusintha pafupipafupi mtima. Kuphatikiza apo, pakuyesa, chidwi chachikulu chiyenera kulipidwa kupweteka m'chifuwa, mitundu yonse ya edema komanso dyspnea yomwe ikuwoneka bwino.

Kulandila pa mimba ndi mkaka wa m`mawere

Akatswiri amaletsa kumwa mankhwalawa kwa amayi omwe ali ndi pakati kapena pakubala. Muzochitika izi, zovuta zam'mapiritsiwo sizingakhale zabwino kwa mayi yekha, komanso kwa mwana wake wosabadwayo.Malangizowa sayenera kuyiwalika, chifukwa odwala ambiri omwe ali ndi thanzi labwino komanso ngakhale kufa adawazindikira pazoyeserera kale.

Kuchita ndi mankhwala ena

Nthawi zambiri pamakhala kuwunikiridwa kwa iwo omwe akuchepetsa thupi za Sibutramine pazokhudzana ndi momwe amapangira mankhwala ena. Pogwiritsa ntchito mankhwala ndi othandizawa, ndikofunikira kukumbukira kuti mukamagwiritsa ntchito mapiritsi oterewa ndi erythromycin, ketoconazole, cyclosporine ndi mankhwala ena omwe amalepheretsa zochitika za CYP3A4, kuchuluka kwa mankhwala a metabolites mu plasma kumatha kuwonjezeka mosavuta, chifukwa chomwe nthawi ya QT ingakulidwe.

Chiwopsezo cha kupitirira kwa serotonin syndrome chidzakulitsidwa pamene mukumwa mankhwala a Sibutramine ndi awa:

• opioid analgesics,
• Paroxetine
• Fluoxetine
• zopondera chifuwa chapakati,
• "Citalopram".

Gwiritsani ntchito kunjaku

Sibutramine ndi mankhwala ofananawa amagwiritsidwa ntchito mwachangu osati ku Russia. Mwachitsanzo, ku United States zinthu zotere zimatuluka pansi pa dzina la "Meridia" ndipo zimangogulitsidwa monga adalangizidwa ndi adokotala. Akatswiri amderali, omwe adayesera ambiri odzipereka omwe ali ndi madigiri osiyanasiyana onenepa, chifukwa chake adalandira anthu ochepa kwambiri omwalira. Pachifukwa ichi, amalola kuti mapiritsi atengedwe kokha ndi odwala athanzi omwe alibe mavuto azaumoyo, makamaka ndi mtima.

Ku European Union, kumasulidwa kwa Sibutramine kudayimitsidwa. Chomwe chidachitika ndichakuti adapezeka kuti akatswiri ofufuza amtundu wa mtima ndi mtsempha wamagazi. Kuti timvetse bwino izi, kafukufuku osiyanasiyana wachitika pa anthu omwe ali ndi matenda a ziwalozi, pomwe zotsatira zake sizinali zolimbikitsa.

Anthu ena sangathe kugula "Sibutramine", chifukwa chake amafunafuna mankhwala omwe ali ofanana ndi iwowa pakuwonetsa komanso mogwira ntchito. Mwamwayi, pali zinthu zambiri zotere. Koma nthawi yomweyo, ndikofunikira kukumbukira kuti ndalama zomwe zimakhala ndi sibutramine zimangogulitsidwa pokhapokha ngati mwalandira mankhwala. Odziwika kwambiri a iwo ndi:

1. Meridia Mankhwala opangidwa ku Germany amapangidwa kuti muchepetse kunenepa komanso kuti wodwalayo azikhala mwamatenda. Amagwiritsidwa ntchito muyezo wowerengeka, ngakhale amafunika mlingo wautali. Chipangizocho chili ndi mndandanda waukulu wazotsatira zoyipa ndi zotsutsana zomwe zimayikidwa pachiwopsezo cha moyo wa munthu.
2. Slimia. Mankhwala abwino amakhala ndi cholinga chochepetsa thupi. Imatha kupititsa patsogolo kagayidwe ka lipid ndikupulumutsa wodwala ku kudalira chakudya. Mankhwalawa ndi othandizadi, koma njira ya mankhwalawa imatha kuposa miyezi isanu ndi umodzi.
3. "Obstat." Chida chopangidwa kuti chikhazikitse kulemera, chimagwira ntchito zambiri, komanso zochulukirapo. Imakonza kadyedwe ndipo imagwiritsidwa ntchito pokhapokha pochiza kunenepa kwambiri.
4. Lindax. Anthu amagula mapiritsi kuti achepetse kudalira zakudya. Madokotala amapereka mankhwala awa kuti asinthe zizolowezi pakudya ngati sikotheka kuthana ndi njala m'njira zina. Mankhwala oterewa siwosokoneza bongo ndipo salola kuti mapangidwe azidalira pazinthu zake.
5. Reducil. Chida ichi chikugwiritsidwa ntchito mmaiko angapo, koma malinga ndi malangizo a dokotala. Zimathandizira kulimbana mapaundi owonjezera mwachangu, osayambitsa chizolowezi.

Ma Analogs a "Sibutramine" nawonso ali. Zosadabwitsa, pakati pawo palibe mawu osagwirizana ndi ogula, popeza anthu amakhutira ndi zomwe akuchita. Ngakhale atakhala ndi zovuta, kugwiritsa ntchito mankhwalawa ndizodabwitsa. Chifukwa cha izi, ma analogu a Sibutramine sakhala otchuka kwambiri.Amagulidwa ndikugwiritsidwa ntchito ndi anthu akumayiko osiyanasiyana, ndikupeza zotsatira zabwino.

Mayankho abwino

Lero pali ndemanga zosiyanasiyana zakutaya thupi za Sibutramin. Amasiyidwa ndi anthu azaka zosiyanasiyana omwe akhalapo kapena akumana ndi izi. Ogula m'mawu awo akuwonetsa zina zomwe zimasiyanitsa mapiritsiwa ndi mankhwala opikisana, komanso ogwira ntchito.

Nthawi zambiri, kuwunika kumatsalira ndi ogula omwe adakumana ndi ndalama zambiri ndipo sanathe kupeza zotsatira kuchokera kwa iwo. Amatsutsa kuti Sibutramin adachepetsa kudya ndipo adathandizira kuti ataya mapaundi oyamba m'sabata yoyamba kuvomerezedwa. Ogwiritsanso ntchito akuti sanakhale ndi zotsatirapo konse kapena kuwonetsa kwakanthawi kochepa, chifukwa chake panalibe chifukwa chodandaula.

Makamaka, anthu amawonetsa kuti akapita kukalandira chithandizo, kulemera ndi chidwi champhamvu sizibwerera. Chifukwa cha izi, popanda kuyesetsa mwamphamvu mutha kukhalabe okwanira komanso kupeza zotsatira zatsopano, koma popanda kuwononga ndalama pamapiritsi.

Ndemanga zopanda pake

Anthu okhawo omwe amawamwa osaganizira zotsutsana ndi malingaliro a madokotala ndi omwe amatsutsa za mapiritsi. Zachidziwikire, chifukwa cha izi, thanzi lawo limakulirakulira, kupweteka kwa mutu ndi chizungulire zinayamba kuwonekera kwambiri, ndipo kulemera kunali kutapita pang'ono.

Bungwe Loona za Umoyo Padziko Lonse lati vuto la kunenepa kwambiri ndi mliri wa zaka za zana la 21. Mwa anthu 7 biliyoni padziko lapansi, miliyoni 1,700 ndi onenepa kwambiri ndipo 500 miliyoni ndi onenepa. Malinga ndi kulosera kukhumudwitsa, pofika chaka cha 2025 kuchuluka kwa anthu onenepa kwambiri kudzapitilira 1 biliyoni! Ku Russia, amuna 46,5% ndi azimayi 51% ndi onenepa kwambiri, ndipo ziwerengerozi zikuchulukirachulukira.

Kunenepa kwambiri pazifukwa zamankhwala amakuwona kukhala wonenepa kwambiri ndi 30% kapena kuposa. Kulemera kumapezeka chifukwa cha wosanjikiza wamafuta, wokhala makamaka m'mimba ndi ntchafu.

Kuphatikiza pa kusokonezeka kwakuthupi ndi kwamaganizidwe, vuto lalikulu la kunenepa kwambiri ndi zovuta: mwayi wokhala ndi matenda am'mimba, matenda a musculoskeletal system, ochepa matenda oopsa, atherosulinosis, ndi matenda amtundu wa 2 ukuwonjezeka.

Kulinganiza kulemera m'malo oterowo mothandizidwa ndi zakudya zolimbitsa thupi komanso zamafashoni sikungatheke kwa aliyense, ambiri amatengera thandizo la mankhwala. Mfundo yodziwitsa ena za mankhwalawa ndi yosiyana: ena amachepetsa kudya, ena amaletsa kuyamwa kwa mafuta ndi mafuta, ndipo ena amakhala ndi vuto lotayirira lomwe silimalola kuti chakudya chizikhala chokwanira.

Mankhwala oopsa amakhala ndi ma contraindication ambiri komanso zotsatira zoyipa. Dokotalayo amawauza kuti ali ndi kunenepa kwambiri, akataya gawo limodzi mwa magawo atatu, kapena ngakhale theka la kulemera kwake m'njira zina sizingatheke.

Mwa zina mwa mankhwalawa ndi Sibutramine (mu mankhwala achi Latin - Sibutramine).

Ntchito yoletsa kukonzanso, yomwe idapangidwa kumapeto kwa zaka zana lapitayo ndi kampani yaku America ya Abbott Laboratories, sikuti adakwaniritsa zomwe amayembekeza, koma adatsimikiza kuti ndiwothandiza kwambiri. Kuchepetsa thupi kunali kwakukulu kwambiri kotero kuti adayamba kusankha odwala omwe ali ndi kunenepa kwambiri, osalamulira kudya kwawo.

Pharmacokinetics a Sibutramine

Mpaka 80% ya mankhwala amkamwa amayamba msanga m'matumbo. Mu chiwindi, imasinthidwa kukhala metabolites - monodemethyl- ndi didemethylsibutramine. Chiwonetsero cha peak cha zomwe zimagwira ntchito chachikulu chinajambulidwa pambuyo pa mphindi 72 kuyambira nthawi yomwe piritsi likugwiritsa ntchito 0.015 g, metabolites imakhala yozama maola 4 otsatira.

Ngati mutenga kapisozi panthawi yachakudya, mphamvu zake zimatsika ndi wachitatu, ndipo nthawi yoti mufikire zotsatira zabwino imakulitsidwa ndi maola atatu (kuchuluka kwathunthu ndikugawa sikusasinthe).Kufikira 90% ya sibutramine ndipo ma metabolites ake amamangiriza seramu albin ndipo amagawidwa mwachangu mu minofu ya minofu.

Ma metabolites osagwira amathandizidwa mkodzo, mpaka 1% amawachotsa ndowe. Hafu ya moyo wa sibutramine ili pafupifupi ola limodzi, ma metabolites ake ndi maola 14-16.

Mankhwalawa adaphunziridwa mu nyama zapakati. Mankhwalawa sanakhudze kubereka, koma poyesa akalulu, mphamvu ya teratogenic ya mankhwala pa mwana wosabadwayo idadziwika. Zochitika zokomera zinaonedwa pakusintha maonekedwe ndi kapangidwe ka mafupa.

Zofananira zonse za Sibutramine zimathetsedwa ngakhale pa gawo lokonzekera kubereka. Ndi kuyamwitsa, mankhwalawa amadziwikanso.

Nthawi yonse ya mankhwalawa ndi Sibutramine ndi masiku 45 atatha, amayi omwe ali ndi zaka zobereka ayenera kugwiritsa ntchito njira zolerera. Musanaganize kuti muchepetse kunenepa ndi mankhwalawo, muyenera kuganizira zakonzekera mimba yanu yotsatira.

Mankhwalawa ndi teratogenic, ndipo ngakhale kuthekera kwake kuyambitsa masinthidwe sanakhazikitsidwe, mankhwalawo alibe umboni wokwanira, ndipo mndandanda wazotsutsana udzathandizidwa.

Malangizo a Sibutramine

Malinga ndi malangizo a sibutramine, si anthu onse omwe angamwe mankhwalawa. Zoyipa pa kutenga sibutramine ndi:

• kutenga ma MA inhibitors (kuphatikiza kutha kwa kudya zosakwana masiku 14 asanatenge sibutramine),
• kumwa mankhwala aliwonse omwe amakhudza dongosolo lamanjenje (kuphatikizapo antidepressants, antipsychotic, mapiritsi ogona, tryptophan, etc.),
• kumwa mankhwala aliwonse kuti muchepetse thupi,
• pakati kapena poyamwitsa,
• kupezeka kwa zoyambitsa organic kunenepa,
• benign Prostatic hyperplasia,
• glaucoma
• hyperteriosis
• pheochromocytoma,
• kuvulala kwambiri kwaimpso kapena chiwindi,
• kuthamanga kwa magazi, matenda oopsa,
• matenda ndi zolakwika za mtima ndi kuzungulira kwa magazi,
• Hypersensitivity
• mankhwala, mankhwala osokoneza bongo,
• zovuta zamagulu akudya (bulimia, anorexia),
• Matenda a Tourette ndi matenda ena amisala.

Malangizo a sibutramine amalepheretsa cholinga chake zotsatirazi:

• khunyu
• nthano za mtundu uliwonse
• zaka zisanachitike zaka 18 ndi zaka 65.

Zotsatira zoyipa, malinga ndi malangizo a sibutramine, omwe angachitike mukamamwa, ndi:

• zosokoneza tulo
• kuchuluka kwamkwiyo, mantha,
• madera okhumudwitsa, nkhawa, mantha kapena kupanda chidwi,
• kusakhazikika mtima
• kamwa yowuma
• kudzimbidwa
• kulakalaka kudya,
• kukomoka
• kukomoka mtima,
• asthenia
• nseru
• gastritis
• mutu, mutu,
• chizungulire
• kupweteka m'khosi, pachifuwa, kumbuyo, kupweteka kwa minofu,
• chifuwa
• chifuwa, mphuno, sinusitis, laryngitis, rhinitis,
• thukuta kwambiri
• Khungu loyipa, zotupa pakhungu,
• thrush, etc.

Malangizo a sibutramine amawonetsa kuchuluka kwa mankhwalawa kwa 10 mg, mogwirizana ndi adokotala, kuwonjezereka kwakanthawi kwa 15 mg ndikotheka. Kutalika kwa kutenga sibutramine chifukwa cha kuchepa thupi kumatha kufika chaka chimodzi.

Sibutramine analogues

Sibutramine ali ndi fanizo. Chimodzi mwazina zodziwika bwino za sibutramine ndi Fluoxetine (Prozac), yomwe imaletsa nkhawa. Zotsatira zoyipa za Prozac ndizopondera. Monga sibutramine, imakhala kutali ndi mankhwala otetezeka, komanso ingavulaze thanzi. Pakati pazofanizira za sibutramine zitha kutchedwa Denfluramine, Dexfenfluramine, Xenical, mankhwala osiyanasiyana - serotonin reuptake inhibitors (sibutramine nawonso ali m'gulu lino la mankhwala). Zofananira zonse za sibutramine zimachita pakatikati kwamanjenje ndipo zimatha kutengedwa pokhapokha poyang'aniridwa ndi dokotala, chifukwa zimatha kuvulaza kwambiri thanzi.

Ndi Sibutramine Slimming Jusified

Lingaliro la momwe angayeneretsere kudya kwa sibutramine pakuchepetsa thupi kumachitika ndi adokotala okha. Ndi iye yekha amene angadziwe kuwopsa kwathanzi lomwe lili lokwera - chiopsezo chotenga mankhwala oopsa kapena chiwopsezo cha kunenepa. Mndandanda wa zotsutsana ndi momwe umalandirira ndiwotakata, ndipo zotsatirapo zake zimawoneka zowopsa. Kukhazikika kosagwiritsidwa ntchito kwa sibutramine kumatha kuvulaza kwambiri thanzi - mbiri ya sibutramine imakhala yodzala ndimilandu yachisoni yodzipha, ma psychoses, kugunda kwamtima ndi stroko zomwe zimachitika ndikumwa mankhwalawa. Ichi ndichifukwa chake sibutramine samatengedwa kugulitsidwa kwaulere ndipo amangopezeka ndi mankhwala okha.

Atsikana amakono amakonda kuchepa thupi komanso kukhala ndi chiuno chochepa. Kupita ku cholinga ichi sikophweka, koma mankhwala osiyanasiyana ndi othandiza kwambiri pankhani yotere. Ndemanga yakuchepera "Sibutramine" imatsutsa kuti mapiritsiwa ndi othandizadi. Chida ichi chimathandizira kuchepetsa thupi mwachangu, koma pokhapokha potsatira malamulo ogwiritsa ntchito ndi kuwasunga.

Pakumva zakugwiritsa ntchito bwino kwa mankhwalawa, anthu ali ndi chidwi ndi malangizo ndikuwunika pa "Sibutramine." M'malo mwake, zimasiyana ndi omwe amapikisana nawo pazinthu zina zomwe zimawonetsedwa ndikugwiritsa ntchito. Ngati simutsatira malamulowo, musayerekeze kuchita zabwino, koma utha kuwononga thanzi lanu m'njira imeneyi mwachangu.

M'nkhaniyi mutha kudziwa zambiri za mankhwalawa. Mndandanda wa Sibutramina, malangizo ogwiritsira ntchito ndi kuwunikira - zonsezi zitha kukhala zothandiza kwa amayi ndi abambo omwe sakhutira ndi mawonekedwe awo.

Mndandanda wa zotsutsana ndi Sibutramine

Kwa anorectics, pali, pazonse, zaka zoyenera: mankhwalawa saikidwa kwa ana ndi akulu (pambuyo pa zaka 65). Pali zotsutsana zina za Sibutramine:

Kuwonetsetsa makamaka poika Sibutramine kuyenera kuperekedwa kwa odwala matenda oopsa, odwala omwe ali ndi vuto la kuthamanga kwa magazi, madandaulo a kupweteka, mbiri yokhala ndi kuperewera kwa magazi, khunyu, chiwindi kapena matenda a impso, glaucoma, cholecystitis, hemorrhage, tics, komanso odwala omwe akumwa mankhwala omwe akukhudza. magazi.

Zotsatira zoyipa

Sibutramine ndi mankhwala oopsa, ndipo monga mankhwala ena alionse ovuta komanso zotsatira zoyipa, sizodabwitsa kuti m'maiko ambiri mankhwala awo ndi oletsedwa. Zosavuta ndizomwe zimachitikira. Osati kudana ndi anaphylactic, inde, koma zotupa za pakhungu ndizotheka. Kuthamanga pakokha kumachitika pamene mankhwalawo amachotsedwa kapena atatha kusintha.

Choyipa chachikulu choopsa ndicho kusuta. Zakumwa zoledzeretsa zaka 1-2, koma ambiri satha kusiya, kulimbitsa kudalira kwa mankhwala, ofanana ndi mankhwala osokoneza bongo. Kuchuluka kwakuthupi kanu komwe kumakhudzidwa ndi Sibutramine, ndizosatheka kudziwa pasadakhale.

Zotsatira zodalirika zitha kuonedwa kale m'mwezi wa 3 wogwiritsidwa ntchito nthawi zonse.

Kuletsa kuyamwa pang'onopang'ono. Mkhalidwe wofanana ndi "kuphwanya" ndi migraine, kulumikizana bwino, kugona pang'ono, kuda nkhawa nthawi zonse, kusakwiya, kusinthana ndi malingaliro opanda chidwi komanso malingaliro ofuna kudzipha.

Mankhwalawa amasokoneza ntchito ya "zopatulikitsa" - ubongo wamunthu komanso zamanjenje. Sizotheka nthawi zonse kukhudza ubongo ndi ubongo wamkati popanda zotsatira za psyche. Kuyesa koyamba pa chithandizo chamankhwala kudatha kudalira kwambiri, kudzipha, kusokonezeka m'maganizo, kufa ndi mtima ndi ubongo.

Mankhwala amakono amatsukidwa kwambiri, mlingo wake umachepetsedwa, koma zotsatira zosayembekezereka siziperekedwa. Ponena ndi kutenga nawo mbali pamagalimoto ndi kasamalidwe ka zinthu zovuta, kugwira ntchito kutalika, m'njira zina zilizonse zomwe zimafunikira kuchitapo kanthu mwachangu ndikuwonjezera chidwi, sizimaloledwa panthawi ya chithandizo ndi Sibutramine.

Ku Sibutramin, malangizo ogwiritsira ntchito akutsimikizira kuti zizindikilo zambiri (tachycardia, hyperemia, matenda oopsa, kusowa kudya, kusintha kwa kukoma, zosokoneza pamtundu wa defecation, hemorrhoids, dyspeptic vuto, thukuta, nkhawa, ndi isomnia) zimatha pambuyo posiya mankhwala.

Kafukufuku wa Sibutramine ku Europe - lingaliro la akatswiri

Kafukufuku wa SCOUT, woyambitsidwa ndi oyang'anira oyenerera a EU atapenda maumboni azachisoni, adakhudzapo odzipereka omwe ali ndi chindoko chachikulu cha thupi komanso chiopsezo chokhala ndi mtima wamtima.

Zotsatira zoyesazi ndizosangalatsa: kuwoneka kwa ma stroko osaphedwa ndi kugunda kwamtima mutatenga Sibutramine kumawonjezeka ndi 16% poyerekeza ndi gulu lolamulira lomwe likulandira placebo.

Zochitika zina zoyipa zimaphatikizira ziwopsezo zosiyanasiyana zakusiyana, kuwonongeka kwa kapangidwe ka magazi (kuchepa kwa ziwalo zam'magazi), kuwonongeka kwa autoimmune kukhoma kwamitsempha, komanso kuvulala kwamisala.

Mchitidwe wamanjenje unapereka zomwe zimachitika mu mawonekedwe a minofu yamasamba, kulephera kukumbukira. Ena mwa ophunzirawo anali ndi zowawa m'makutu, kumbuyo, mutu, komanso masomphenya komanso kumva. Matenda am'mimba nawonso adawonedwa. Pamapeto pa lipotilo, zidadziwika kuti kusiya mankhwala kumatha kuyambitsa mutu komanso kusadandaula.

Werengani zambiri za momwe Sibutramine amawotcha mafuta ndikuwongolera kusinthasintha - muvidiyo

Momwe mungagwiritsire ntchito anorectics

Piritsi imatengedwa kamodzi. Nthawi yakudya siyimakhudza zotsatira zake. Kumayambiriro kwa maphunzirowa, ndikulimbikitsidwa kumwa kapisozi imodzi yolemera 0,01 g. Amamezedwa yonse ndikutsukidwa ndi madzi.

Ngati m'mwezi woyamba kulemera kwapita mkati mwa 2 kg ndipo mankhwalawo amalekeredwa pafupipafupi, mutha kuwonjezera kuchuluka kwa 0, 015 g Ngati m'mwezi wotsatira kulemera kumachepera 2 kg, mankhwalawo amathetsedwa, chifukwa ndiwowopsa kusintha mankhwalawa mopitirira.

Lowetsani chithandizo cha milandu zotsatirazi:

1. Ngati zosakwana 5% za misa yoyambirira zimatayika m'miyezi itatu,
2. Ngati njira yochepetsera thupi yaima pazowonetsa mpaka 5% ya misa yoyamba,
3. Wodwalayo adayambanso kulemera (atachepetsa thupi).

Kuti mumve zambiri za Sibutramine, onani maphunziro pa kanema:

Bongo

Kulephera kutsatira malingaliro, kuwonjezereka Mlingo kumawonjezera chiopsezo cha bongo. Zotsatira za zotere sizinaphunziridwe mokwanira, kotero, mankhwalawa sanakhazikike. Mu mawonekedwe a chisamaliro chodzidzimutsa cha zizindikiro zotere, m'mimba mumatsukidwa kwa wozunzidwayo, ma enterosorbents amaperekedwa ngati osapitirira ola limodzi atatha kugwiritsa ntchito Sibutramine.

Onani kusintha kwamunthu amene akuzunzidwa masana. Ngati zizindikiro za zoyipa zikuwonetsedwa, chithandizo chamankhwala chimachitika. Nthawi zambiri kuposa ena, pamakhala kuthamanga kwa magazi komanso kuthamanga kwa mtima. Zizindikiro zotere zimasiya ndi β-blockers.

Kugwiritsidwa ntchito kwa zida "zama impso" ngati vuto la mankhwala osokoneza bongo a Sibutramine sililungamitsidwa, popeza metabolites ya mankhwalawa sikutha chifukwa cha hemodialysis.

Migwirizidwe yogula ndi kusungidwa

Ngakhale kuti m'maiko ambiri Sibutramin ndi yoletsedwa mu chipatala chovomerezeka, Intaneti ndi yodzaza ndi zinthu zotere. Chifukwa chake mutha kugula ma anorectics popanda mankhwala. Zowona, zotsatirapo pankhaniyi ziyenera kusamaliridwa payekha. Kwa Sibutramin, mtengo (pafupifupi ma ruble 2,000) ulinso wa aliyense.

Malamulo osungira mankhwalawa ndi muyezo: kutentha kwa chipinda (mpaka 25 ° C), kuwongolera moyo wa alumali (mpaka zaka 3, malinga ndi malangizo) ndi kupezeka kwa ana. Mapiritsi amasungidwa bwino kwambiri m'mapulogalamu awo oyambira.

Sibutramine - analogues

Umboni waukulu kwambiri (koma osati wotsika mtengo) uli ndi Xenical - mankhwala omwe ali ndi mankhwala ofananawo, omwe amagwiritsidwa ntchito mu kunenepa kwambiri. Pamaintaneti ogulitsa pamakhala mawu ofanana a Orlistat. Gawo lolimbikira limaletsa kuyamwa kwa mafuta ndi makoma am'matumbo ndikuwachotsa mwachilengedwe.Mphamvu yokhazikika (20% yapamwamba) imawonetsedwa pokhapokha pakudya.

Zotsatira zoyipa zimawonedwa m'njira zosokoneza mu mtundu wa defecation, flatulence. Kukula kwa Zizindikiro zimatengera zakudya zomwe zimapatsa mphamvu: mafuta omwe amapatsa chakudya, mphamvu yamatumbo.

Kusiyana pakati pa Sibutramine ndi Xenical ndikuthekera kwama pharmacological: ngati wakaleyo amachepetsa chilimbikitso pochita ubongo ndi malo amitsempha, omaliza amachotsa mafuta, kumangirira kwa iwo ndikukakamiza thupi kuti lizigwiritsa ntchito mafuta ake mokwanira kulipirira ndalama zowonjezera mphamvu. Kudzera mwa dongosolo lamkati lamanjenje, Sibutramine imagwira ziwalo zonse za machitidwe, Xenical simalowa mthupi mozungulira ndipo samakhudza ziwalo ndi machitidwe.

Fenfluramine ndi analogue ya serotonergic kuchokera pagulu la amphetamine. Ili ndi makina ofanana ndi Sibutramine ndipo ndi oletsedwa pamsika ngati zinthu zosokoneza bongo.

Fluoxetine, antidepressant yomwe imapanikiza kupindika kwa serotonin, ilinso ndi mphamvu yowonjezera anorectic.

Mndandandawu ukhoza kuphatikizidwa, koma mankhwala onse a anorexigenic, ngati oyambirirawo, ali ndi zovuta zambiri ndipo amatha kuvulaza thanzi. Zoyambirira sizikhala ndi ma analogi okhathamira, magwiritsidwe azomwe amapanga omwe amapanga India ndi ochulukirapo kapena osadziwika - Slimia, Gold Line, Redus. Sitiyeneranso kulankhula za zowonjezera zazakudya zaku China - mphaka 100% mu poke.

Kuwala kwa Reduxin - zakudya zowonjezera zochokera ku oxetriptan, zomwe sizigwirizana ndi sibutramine, zimakhala ndi mphamvu yosintha, ndipo zimalepheretsa chilakolako chofuna kudya. Kodi pali ma fanizo otsika mtengo a Sibutramine? Zakudya zopezekera za Lista ndi Gold Line Light zili ndi mawonekedwe osiyanasiyana, koma kapangidwe kake kamafanana ndi Sibutramine yoyambirira. Chinyengo chotsatsira chotere sichikhudza mtundu wa zowonjezera.

Maganizo a kuchepa thupi komanso madokotala

Ndemanga zina zikudetsa nkhawa za Sibutramine, ozunzidwawa komanso abale awo akuwopsezedwa ndi zotsatira zoyipa, akuwalimbikitsa kuti asiye mankhwala. Koma omwe adapulumuka nthawi yosinthira ndipo sanasiye maphunzirowa anali patsogolo.

Andrey, wazaka 37. Ndakhala ndikutenga Sibutramine kwa sabata limodzi lokha, koma zimandithandizira kuthana ndi njala. Kuopa zachilendo ndi kuwopseza "anzeru" pang'onopang'ono kudutsa. Masiku awiri oyamba mutu unali wolemera, tsopano pakadali pakamwa pouma. Sindinataye mphamvu ndipo, makamaka, kufuna kudzipha. Ndimadya kawiri pa tsiku, koma inunso mutha kumadya kamodzi patsiku: ndimadya kwambiri kuchokera kumgawo umodzi wocheperako. Ndimamwa kapu imodzi yamafuta owotcha ndi chakudya. Izi zisanachitike, ndipo usiku sanasiye firiji. Pomwe kulemera kwanga kuli makilogalamu 119 ndikuwonjezeka kwa masentimita 190. Pali mphamvu zokwanira kuti ndikwere malo opingasa. Ngati wina aliyense amasamala za kugonana, ndiye kuti zonse zili bwino.

Valeria, wazaka 54. Sibutramine ndi mankhwala amphamvu, ndinataya makilogalamu 15 m'miyezi isanu ndi umodzi. Popeza ndili ndi matenda ashuga, kupambana kumeneku kumawerengedwa kawiri konse. Poyamba, panali zovuta kuchokera kwa Sibutromin - m'mimba mudakhumudwa, thupi lidali kuyabwa, mutu ukupweteka. Ndinaganiza zosiya maphunzirowo, koma adotolo andipatsa mankhwala ochepetsa mphamvu ya chiwindi ndi impso. Pang'onopang'ono, zonse zidapita, tsopano ndi Sibutramin yekha amene amatenga piritsi limodzi ndi Metformin wanga wobadwira. Ndikumva bwino - kugona kwanga ndikuyenda bwino.

About Sibutramine, kuwunika kwa madokotala kumaletsa kwambiri: madokotala samakana kugwira ntchito kwakukulu kwa Sibutramine, amakumbutsa kutsatira molondola malangizo omwe mumalandira ndikuwunika kawirikawiri kuti muchepetse kunenepa. Amachenjeza za kuopsa kodzipangira nokha mankhwala, popeza mankhwalawa ndi akulu kwambiri ndipo palibe otetezeka pazotsatira zoyipa.

Malinga ndi ziwerengero, osachepera chimodzi mwa zosasangalatsa zomwe amakumana ndi 50% ya iwo omwe amalemera ndi Sibutramine. Sizodziwika kuti mankhwalawa aletsedwa m'maiko ambiri otukuka, ndipo Russia ikuphatikizidwanso m'ndandanda wazomwe zingagwiritsidwe ntchito.

Sibutramine ndi mankhwala a anorexigenic othandiza kuchepetsa thupi, omwe amalembedwa molingana ndi zisonyezo zochizira kunenepa kwambiri.Komabe, kugwiritsa ntchito mankhwalawa mosasamala kapena mosayenera kumatha kubweretsa zotsatirapo zosiyanasiyana zosasangalatsa.

Kupanga ndi mlingo

The yogwira pophika mankhwala - sibutramine hydrochloride - amapezeka mawonekedwe a kapisozi 10 ndi 15 mg. Imagwiritsidwa ntchito ngati chida chowonjezera polimbana ndi kunenepa kwambiri kwa thupi. Sibutramine imagwiritsidwa ntchito molumikizana ndi zakudya zomwe zimayang'aniridwa mosamala komanso kuwonjezera zolimbitsa thupi. Mankhwalawa amachepetsa kudya komanso kuchuluka kwa zakudya zomwe wodwala amadya, kumawonjezera Thermogeneis komanso kumakhudza minofu ya bulauni ya adipose.

Pochiritsira, odwala amakhala ndi kuwonjezeka pang'ono kwa kuthamanga kwa magazi kupumula (ndi 2-4 mmHg) komanso kuwonjezeka kwa kugunda kwa mtima (mwa kumenyedwa kwa 4-8 pamphindi), koma nthawi zina kusintha kwakukulu nkotheka.

Malinga ndi kunena kwa mankhwalawa, mankhwalawa amagwiritsidwa ntchito kamodzi patsiku (makamaka m'mawa) ndipo mlingo woyambayo si woposa 10 mg (osalekerera bwino - mlingo uyenera kuchepetsedwa mpaka 5 mg patsiku). Ngati palibe zotsatirapo zake, dokotalayo amatha kuwonjezera mlingo wake mpaka 15 mg pa tsiku pambuyo pa masabata anayi. Kutalika kwa chithandizo, kutengera zotsatira zake, zitha kukhala miyezi 12.

Munthawi ya chithandizo ndi Sibutramine, ndikofunikira kuwunika kuchuluka kwa kuthamanga kwa magazi ndi kugunda kwa mtima kwa masiku 14 aliwonse m'miyezi iwiri yoyambirira ya mankhwalawa, ndikuchepetsa mpaka 1 mwezi uliwonse. Kwa anthu omwe ali ndi matenda oopsa, opsinjika ndi 145/90 mm Hg, mankhwalawa amayenera kusokonezedwa ndipo adotolo ayenera kufunsa uphungu.

Mawonekedwe pakumwa mankhwala opweteka pachifuwa, kupuma movutikira (dyspnea) ndi kutupa kwa m'munsi mwake kukuwonetsa chitukuko cha matenda oopsa a m'mapapo, pakadali pano, muyenera kulumikizananso ndi madokotala.

Zotsatira zake

Zina mwazotsatira zoyipa:

• madontho ndikuwonjezereka kwa kuthamanga kwa magazi,
• mavuto amtima,
• kutaya mtima,
• kusinthasintha.

Zotsatira zodziwika bwino zogwiritsa ntchito Sibutramine ndizizindikiro zomwe zimafanana ndi kusiyanasiyana ndi omwe ali osokoneza bongo. Uku ndi kuda nkhawa, kupha nyama, kusokoneza tulo, kugwirizanitsa, kusapeza bwino komanso mtima wofuna kudzipha. Nthawi zina, pamakhala kukomoka, kunjenjemera kwa malekezero, kupweteka kumbuyo kwa kumbuyo, kumva kukomoka, kutupa, kufupika.

Mankhwalawa amasokoneza mawonekedwe a mphuno yolimba, kupweteka kwa minofu, kutupa kwa mucous m'mimba ndi matumbo, kuchepa kwa chilakolako chogonana. Ntchito ya sebaceous ndi thukuta tiziwopsezedwa imasokonezeka, chifukwa cha zomwe ziphuphu zimawonekera pa thupi, thukuta limakulirakulira, msambo umatha kusokonezeka. Kupanga malovu kumawonongeka, zomwe zimakwiyitsa maonekedwe a zilonda mkamwa, ma caries amatha kuyamba.

Zovuta zochepa komanso zovuta kwambiri zotenga Sibutramine ndi serotonin ndi zilonda za antipsychotic. Zizindikiro zake zimaphatikizira kukwiya, nkhawa, kutentha thupi, kutsegula m'mimba, kusanza, kusanza, komanso kupweteka. Ngati chimodzi mwazizindikirozi chikuwoneka, ndikulimbikitsidwa kuti mupite kuchipatala msanga.

Mankhwalawa mankhwala omwe ali ndi yogwira mankhwala sibutramine, ndipo atamaliza, muyenera kupimidwa kuchipatala kuti muwone kuwonda komanso thanzi la wodwalayo.

Ndi mowa

Mukamagwiritsa ntchito Sibutramine, mowa ndi mankhwala omwe amachepetsa kugona ayenera kusiyidwa. Chipangizocho chimatha kuyambitsa chizungulire kapena chizungulire cha zinthu zooneka, izi zimathandizidwa ngati mumamwa mowa, zomwe zimapangitsa kuti munthu aziyendetsa galimoto kapena kugwira ntchito yolumikizidwa ndi chidwi chochulukirapo komanso kuthamanga kwa zomwe zimachitika.

Mimba

Kafukufuku wazinyama adawonetsa kuti kugwiritsa ntchito mankhwalawa ndi amayi apakati komanso oyamwa kumayambitsa kuwonongeka kwa ana.Kuphatikiza apo, tikulimbikitsidwa kugwiritsa ntchito njira zakulera zodalirika, chifukwa mankhwalawa amakhudza kwambiri chitukuko cha mwana wosabadwa ngati ali ndi pakati pa mankhwala.

Pazomwe zimagwira, othandizira a Sibutramine ndi Lindax, Goldline, Meridia ndi Slimia. Ngati ndi kotheka, katswiri amatha kusintha mankhwalawo pogwiritsa ntchito fanizo limodzi: Fepranon ndi amfepramone, ndi Reduxin, omwe ali ndi cellcrystalline cellulose kuphatikiza sibutramine.

Njira yochepetsera thupi imakhala yovuta kwambiri kotero kuti njira iliyonse yothandizira mwa izo imakhala yabwino. Izi zimagwiranso ntchito kwa mankhwala osokoneza bongo. Sibutramine ndi mawonekedwe ake amafunika ulemu wapadera pakati pa iwo omwe amachepetsa thupi. Izi zidagawidwa m'magawo a Russian Federation ndipo zidagulitsidwa ndi mankhwala, monga zikuwonetsedwa bwino ndi malangizo a Sibutramine. Koma pakadali pano, m'mafakitala, mankhwala omwe ali ndi dzinali sangathe kupezeka. Pali ma analogu ake omwe ali ndi sibutramine ngati chinthu chogwira ntchito.

Zinali ngati mankhwala ochepetsa mphamvu kuti mchere wa sibutramine hydrochloride monohydrate upangike. Kuphatikizika kwake kunachitika ndi asayansi aku America. Pakuyesa kwa mankhwalawa, zidapezeka kuti kumwa mankhwalawo chifukwa chogwiritsidwa ntchito sikothandiza - palinso zovuta komanso zovuta zingapo pakuphatikiza ndi mankhwala ena. Popanga kafukufuku, anorexigenic zotsatira adadziwika chifukwa cha sibutramine - kuthekera kuletsa chidwi chamthupi pamlingo wamkati wamanjenje, pambuyo pake mankhwalawa adawerengedwa ngati njira yochepetsera thupi.

Kupambana mu Zakudya

Pakadali pano, sibutramine mu mankhwalawa amalembedwa pa 10 ndi 15 mg. Panthawi yoyesa mankhwala, mankhwalawa amagwiritsidwa ntchito omwe anali apamwamba kwambiri kuposa mlingo wapano. Zotsatira zake - kuchepa thupi kunali kosavuta komanso mwachangu. Chidwi cha wodwalayo chinali chitasowa kwathunthu, ndipo malo ogulitsa mafuta anali kugwiritsidwa ntchito kawiri konse, chifukwa mphamvu za thupi zimafunikira kukhutitsidwa kosalekeza.

Sibutramine inayamba kukhala yogwira pothana ndi kuchuluka kwa thupi, pomwe mndandanda wamankhwala wambiri unapita pazaka 30. Kugwiritsa ntchito milingo yayikulu kumayendera limodzi ndi zovuta zingapo, kuphatikizapo:

• kugwidwa mtima
• kutentha kwa mtima
• zotupa za m'mimba,
• kupweteka kwa migraine
• mavuto amisala.

Chifukwa chake, panthawiyo sakanatha kuyambitsa mankhwalawo kuti azigwiritsidwa ntchito kwambiri. Atapeza njira zochepa zochizira, asayansi adapeza zabwino pakuchepetsa mavuto, zomwe zidapangitsa kutilembetsere mankhwala ngati mankhwala ochizira kunenepa.

Makampani ambiri azachipatala adayambitsa formula ndi fanizo lake. Komabe, izi sizinayende bwino kwenikweni, popeza mauthenga anapitilizabe za zovuta zina. Zotsatira zake, kuyambira 2010, America ndi European Union aphatikiza sibutramine pamndandanda wa mankhwala oletsedwa. Maiko ena, mwachitsanzo, Russia, adaliphatikiza pamndandanda wamankhwala okhathamira omwe amathandizira, zomwe zimachepetsa kwambiri mwayi wodzipatsa okha mankhwala.

Kuchepetsa thupi

"Sibutramine" kapena fanizo lake limafotokozedwa ndi akatswiri azakudya zamagetsi kapena amisala kwa anthu omwe ali ndi vuto la kunenepa kwambiri komanso omwe ali ndi vuto lakudya. Nthawi zambiri kuikidwa kumachitika ngati njira zina zochepetsera thupi zatha. Sibutramine amachita pakhungu lotsatira:

• Imaletsa kugwidwa kwa ma neurotransmitter serotonin,
• imaletsa kugwidwa kwa neurotransmitter norepinephrine,
• Kuchepetsa kwambiri zomwe zimalepheretsa kupezeka kwa dopamine.

Kuphwanya zakumwa ndi kusinthana kwa oyimira pakati pakatikati wamanjenje kumabweretsa chitukuko chofanana cha ziwalo zonse. Zotsatira za kutenga sibutramine ndi izi:

• chilala - wodwala akumva kuwawa kwambiri, sangathe kuzimva, ngakhale patalibe chakudya chimodzi tsiku limodzi,
• kagayidwe - chifukwa cha kamvekedwe ka mtima, kusintha kwa kutentha kumawonjezeka, thupi limakakamizidwa kuti ligwiritse ntchito mphamvu zambiri, pogwiritsa ntchito nkhokwe zake kuchokera ku depos,
• kutentha kwa mafuta - kutengera zomwe zidachitika kale, chifukwa mphamvu zakunja zimachepa,
• kukomoka - chifukwa cha kudya, chidwi cha wodwalayo chimachitika nthawi yomweyo chakudya chikayamba.
• chimbudzi - chimakula bwino chifukwa chakuwonjezeka kwa ndende ya serotonin mucous membrane ya m'mimba (gIT), ma peristalsis ndi kapangidwe ka mandimu,
• Kusintha - kumachitika bwino chifukwa cha kuchuluka kwa "mahomoni achisangalalo", wodwala amasangalala ngakhale zitakhala kuti akudalira chakudya,
• ntchito - kumawonjezeka chifukwa chowonjezeka kwambiri cha chapakati mantha dongosolo, wodwalayo akumva kuwonjezeka mphamvu, mphamvu, okonzekera kuchitapo tsiku lonse.

Kusintha kambiri mu ntchito ya ubongo komwe kumakhudzidwa ndi kugwiritsa ntchito sibutramine kumathandizira kuchepetsa kunenepa kwambiri pamlingo wonse: mwakuthupi, mwamaganizidwe, m'thupi. Chimodzi mwa mankhwalawa ndikutha kulimbikitsa kuwotcha "mafuta a bulauni". Ngakhale izi ndizomwe zimapangidwira yaying'ono mthupi la munthu, zimagwira gawo lofunikira kwambiri pakuwonjezera kutentha. Ndipo kugawanika kwawo kumayambitsa kudyedwa kwa "mafuta oyera", owonjezera omwe amatsatira kunenepa kwambiri.

Komanso ndizofala kwa sibutramine kuti azitha kuyendetsa bwino mafuta m'thupi. Makamaka, mankhwalawa amayambitsa kupanga ndi kubisala kwa bile. Pazifukwa izi, zikuwonetsa kugwiritsidwa ntchito kwa mankhwalawa kumaphatikizapo kunenepa kwambiri mu mtundu 2 wa matenda a shuga ndi lipid metabolism. Mkhalidwe wokhazikitsidwa ndi sibutramine pamilandu iyi ndiwowonjezera wa index yamtundu wa 27.

Malangizo ogwiritsira ntchito sibutramine

Sibutramine ndi m'gulu la mankhwala onenepa omwe amatsata "monga chomaliza chomaliza". Kulandila ndalama kuyenera kuvomerezana ndi dokotala kuti awonetsetse kuti njira zonse zomwe zilipo pakuwongolera thupi zimatha. Njirayi ndiyofunika chifukwa cha chiwopsezo chachikulu cha thanzi chomwe chadzala ndi kusokonezedwa pakugwira ntchito kwamanjenje.

Nthawi zambiri, kudya kumayamba ndi 10 mg. Piritsi limodzi la mulingo woyenera amatengedwa kamodzi kuti agwe pansi ndimadzi okwanira. Kumwa mankhwalawa sikudalira nthawi ya chakudyacho, koma madokotala amalimbikitsa kumwa mapiritsi m'mawa wopanda kanthu pambuyo podzuka kuti atsimikizire kuchuluka kwa mankhwalawa m'magazi m'mawa.

Izi zikuchitika motere:

• 80% yazomwe zili piritsi zimalowa m'matumbo aang'ono,
• metabolites yogwira ya sibutramine - imatulutsidwa m'mwazi ndikumanga mapuloteni ake,
• Mitsempha yamagazi imakwana - patatha maola atatu kapena anayi atamwa
• metabolites a mankhwalawa - amagawidwa mthupi lonse, kudziunjikira mafupa a synaptic,
• mutatenga piritsi lachinayi, njira yokhazikika yodalirika yamankhwala imatheka.

Kulandila ndikosayenera kuphatikiza ndi chakudya. Chowonadi ndikuti kuyamwa kwa mankhwalawa kuchokera pachakudya cha chakudya ndikulakwika - amachepetsa ndi wachitatu. Thupi limachotsedwa m'thupi ndi impso. Zidutswa za metabolites zili mu minyewa pafupifupi mwezi umodzi, koma kugwiritsidwa ntchito kwawo kumapeto kwa kayendetsedwe sikumakhudza zochizira.

Mapiritsi a zakudya a Sibutramin amatha kumwa mpaka chaka. Tsopano amathanso kumwa ma analogues. Ngati mulingo wocheperako wa 10 mg ndiwokhutiritsa, umakhalabe mpaka kumapeto kwa chithandizo.Kufunika kwa kuchuluka kwa mankhwalawa kumachitika ngati, pakatha miyezi iwiri kapena itatu kuyambira pomwe amayamba kudya, "plumb" ya wodwalayo imafika 3% ya kulemera konse kwa thupi. Kenako mankhwala a sibutramine mu 15 mg. Zingachitike kuti chingwe cholimira sichikhala chochepa kwambiri, mankhwalawo amachotsedwa chifukwa chosakwanira. Zisankho zonse zokhudzana ndi kuchuluka kwa mankhwalawa, komanso nthawi yanthawi yamankhwala, zimapangidwa ndi dokotala.

Zowopsa

Popeza chithandizo chokwanira cha mankhwalawo pakuchepetsa thupi, funso limadzuka: "Ndilipira chiyani pothandizidwa mooneka bwino panjira yolumikizana?" Yankho lagona mu zotsatira za kafukufuku wa chinthu, chomwe chimawonetsa bwino mavuto ake. Koma poyang'ana za kuwunikira kwa kunenepa, titha kunena kuti mankhwalawa nthawi zambiri amaloledwa. Zina zoyipa zomwe zimachitika kumayambiriro kwa mankhwalawa zimataya mphamvu kapena zimatha kwathunthu ngati sibutramine yatengedwa moyenera. Zotsatira zoyipa kwambiri:

• kamwa yowuma
• kuphwanya chopondapo
• kuchuluka kwa zotupa m'mimba,
• mutu
• kugunda kwa mtima
• kusowa tulo
• kusowa kudya kwathunthu,
• kuchuluka pang'ono kwa kuthamanga kwa magazi.

Zotsatira zoyipa za sibutramine, monga momwe zimakhalira ndi mankhwala ena, zimaphatikizanso mwayi wokhudzana ndi matendawa, wowonetsedwa ndi urticaria ndi pruritus. Pankhaniyi, mankhwalawa adathetsedwa.

Zotsatira zoyipa zoopsa za mankhwalawa zimaphatikizaponso kusuta ndi kusiya. Kudalira mankhwala osokoneza bongo sikuchitika, koma nthawi yoyamba atasiya kulandira chithandizo, wodwalayo amatha kukhala ndi nkhawa kwambiri, zomwe zimatha kubweretsanso chizolowezi chamadyedwe akale. Kuti achepetse kuchuluka kwa zotulukazi, madokotala amalimbikitsa kusiya kuyamwa, pang'onopang'ono kuchepetsa Mlingo wa mankhwalawa.

Zowopsa zosakhudzidwa ndikuphatikizapo:

• mavuto amisala (mpaka kufuna kudzipha),
• Mavuto azakudya (bulimia, anorexia),
• chiopsezo chowopsa cha matenda a mtima,
• kusowa tulo
• kuchuluka kwakukulu kwa kuthamanga kwa magazi,
• tachycardia
• kukomoka
• kusokonekera kwa kufalikira kwazungulira.

Popeza kuti sibutramine m'mbuyomu ikhoza kugulidwa popanda mankhwala, mavuto ena sangakhale olembetsedwa ndi wopanga ndipo osawonetsedwa muzowongolera. Madokotala amayang'ana chidwi cha iwo omwe akuchepetsa kulemera kwa kufunikira kwa mankhwala othandizira. Pokhapokha motere mwayi wokhala ndi zotsatirapo zake umachepetsedwa kwambiri.

Sibutramine ndi chiyani?

Ngati kuyesera kambiri kuti muchepetse thupi sikubweretsera zotsatira zilizonse ndipo njira zambiri zogwira ntchito zakhala zikugwiritsidwa ntchito kuti muchepetse kunenepa, anthu amadzidalira. Ndipo izi zitha kukhala poyambira pokhazikitsa zovuta zakuya zama maganizo komanso kukhumudwa kwambiri. Mwina ndichifukwa chake ambiri ochepetsa thupi amakhulupirira kuti kuchepa thupi kumatha kuchitika pogwiritsa ntchito mankhwala, mwachitsanzo, mankhwala ngati Sibutramin. Ichi ndi chiyani Ubwino wopanda malire womwe udzachotsa muzu wazoyipa, kapena bomba lomwe lingawononge thanzi laumunthu pamapeto pake?

Ndikofunikira kumvetsetsa kuti Sibutramine ndi mankhwala amphamvu, osati chinthu chopanda vuto lililonse. Ndipo chifukwa chake, iwo, monga mankhwala aliwonse, ali ndi zotsutsana, zoyipa ndipo zimakhala ndi zotsutsana ndi thupi.

Pankhaniyi, ndikofunikira, musanayambe kumwa mankhwalawa, funsani ndi dokotala wanu za kugwiritsa ntchito mankhwalawa. Koma pambuyo pa zonse, anthu adachepetsa thupi potenga Sibutramin, ndemanga za iwo omwe amachepetsa thupi m'njira zonse zimatsimikizira izi, mukuti. Koma izi zidawonongeka ndi zotsatila zanji ndipo zidakhala ndi zotsatilapo ziti mutatha kutenga Sibutramine? Nkhaniyi iyesa kuyankha mafunso awa ndi enanso.

Ichi ndi chinthu chapakati chamankhwala othandizira odwala kunenepa.Iyenera kugwiritsidwa ntchito limodzi ndi zakudya zomwe zimayendetsedwa mosamalitsa komanso kuwonjezera zolimbitsa thupi. Mutamwa mankhwalawa "Sibutramine" (mapiritsi kapena mapiritsi), kumverera kwodzaza kumachitika. Ndiye kuti, ngakhale gawo laling'ono la chakudya limapatsa munthu kumva kuti ndi wofooka. Ndipo izi zimayambitsa kuchepa kwa chakudya. Poletsa kubwezeretsanso kwa serotonin, mankhwala a Sibutramine amakhudza pakati penipeni pa ubongo omwe amakhala ndi chidwi chofuna kudya.

Malangizo apadera

Kugwiritsa ntchito mankhwalawa kumatheka pokhapokha ngati njira zina zonse zolemera kuchepetsa thupi sizothandiza. Chifukwa chake, pokhapokha pokhapokha pofunika kugwiritsa ntchito Sibutramine. Kuchepetsa zowunikira makamaka kumakhala ndi chidziwitso choti mphamvu ikukula. Therapy iyenera kuchitika moyang'aniridwa ndi dokotala yemwe amadziwa bwino kukonza kunenepa ngati mbali ya chithandizo chokwanira, monga:

1. Zakudya
2. Sinthani mumakhalidwe anu akudya
3. Kuchulukitsa zolimbitsa thupi.

Zotsatira zoyipa

Kuwerenga ndemanga zambiri, makamaka zomwe zimafotokoza zakumwa pambuyo pomwa mankhwalawa, mumaganiza mwadala kuti ambiri amangolemba zilonda zawo mankhwalawa. Zowonadi, ngakhale "Analgin" yosavuta komanso yodziwika bwino imayambitsa zochitika zofananira pambuyo pake kukhazikitsidwa. Komabe, ndibwino, musanatenge "Sibutramine", ndemanga za madokotala, zotsatira zoyipa kuti muphunzire mosamala. Chotheka:

1. Mutu ndi chizungulire.
2. Kusowa tulo
3. Kumva mantha komanso kusangalala.
4. Amalumphira kuthamanga kwa magazi.
5. Tachycardia.
6. Arrhasmia.
7. Zovuta.
8. Mavuto a Stool.
9. Pakamwa pakamwa.
10. Kusanza ndi kusanza.
11. Kutukwana.
12. Kusintha mu psyche ndi machitidwe.
13. Sinthani
14. Ululu wammbuyo.
15. Thupi lawo siligwirizana.
16. Matenda a chimfine.
17. Matenda amitsempha.
18. Laryngitis
19. Kuchulukitsa kutsokomola.
20. Zomwe zimapangitsa kuti munthu asamwe mankhwala osokoneza bongo.

Njira zopewera kupewa ngozi

Muyenera kumvetsetsa kuti mphamvu ya mankhwalawa idzaonekere limodzi ndi zakudya. Ndikofunikira kugwiritsa ntchito mosamala pogwiritsa ntchito Sibutramine, mankhwala omwe amachepetsa thupi omwe afotokozedwa gawo loyambalo. Kupatula apo, zina mwazomwe zimachitika mthupi la munthu zimadziwika kale.

Ndikofunikanso kutsatira zina kwa anthu omwe amagwiritsa ntchito mankhwalawa. Izi ndi machitidwe osamala, kutsatira zomwe sizingabweretse mavuto:

1. Ukalamba wa wodwala.
2. Kuyendetsa galimoto.
3. Gwirani ntchito ndi zofunikira.
4. Kugwiritsa ntchito moyenera mankhwala ndi mowa. Sibutramine imawonjezera mphamvu yositsa ya mowa.

Reduxin ndi mankhwala ochokera ku gulu la anorexigens, chisonyezo chogwiritsa ntchito chomwe ndi kunenepa kwambiri kwamamadzi. Kapangidwe kake ka mankhwalawa amaphatikizanso yogwira cell sibutramine ndi microcrystalline cellulose.

Oyamba amachita pakatikati wamanjenje, amachititsa kuti akhale ndi chidzalo. Chachiwiri chimadzaza m'mimba, kutsekereza kumverera kwanjala. Munthu amadya chakudya chochepa kwambiri osakumana ndi mavuto, monga zimachitikira ndi zakudya zovuta. Chifukwa chake, ephexin nthawi zambiri amatengedwa kuti muchepetse kunenepa.

Mankhwala a reducin ndi mankhwala omwe ali ndi mndandanda wosangalatsa wa zotsutsana. Sizingatengedwe ngati pali zovuta ndi impso, mtima, chiwindi, nthawi yapakati, nthawi yoyamwitsa, muubwana. Mankhwalawa amapangidwa ku Russia ndi oletsedwa m'maiko angapo ku Europe ndi United States, koma kuweruza ndi kuwunika kozama, mdziko lathu, chidachi ndi chotchuka.

Mtengo wokwera wa mapiritsi ndi njira ina yobweretsera tsoxin. Phukusi lokhala ndi makapisozi 30 limatenga ma ruble a 1900, ndipo makapisozi 90 amatenga ndalama zokwanira 6300. Njira yoyenera yotsika mtengo wa mankhwala ochepetsa thupi nthawi zambiri imafunidwa pakati pa olowa nawo kapena mawu ofanana ku Russia.

Analogi opanga Russian

Tebulo ili ndi yankho ku funso loti "analoxin analogues ndiotsika mtengo" kuchokera pakati pa mankhwala ochokera kwa wopanga.