Forsiga - chida chatsopano chothandizira matenda a shuga

Piritsi limodzi lachifundo 1, Forsig 5 mg ili ndi:

• Zogwira pophika: dapagliflozin propanediol monohydrate 6.150 mg, malinga ndi dapagliflosin 5 mg,
• Omwe amathandizira: cellcrystalline cellulose 85.725 mg, anactrous lactose 25,000 mg, crospovidone 5,000 mg, silicon dioxide 1,875 mg, magnesium stearate 1,250 mg,
• Chigoba cha phale: Opadry II chikasu 5,000 mg (polyvinyl mowa pang'ono hydrolyzed 2,000 mg, titanium dioxide 1,177 mg, macrogol 3350 1,010 mg, talc 0.740 mg, utoto wa iron oxide chikasu 0,073 mg).

Piritsi limodzi lokhazikika mu filimu 1, Forsig 10 mg ili ndi:

• Yogwira pophika: dapagliflosin propanediol monohydrate 12,30 mg, yowerengedwa ngati dapagliflosin 10 mg,
• Omwe amathandizira: microcrystalline cellulose 171.45 mg, anactrous lactose 50.00 mg, crospovidone 10.00 mg, silicon dioxide 3.75 mg, magnesium stearate 2.50 mg,
• Chipolopolo cha piritsi: Opadray® II chikasu 10,00 mg (mowa wa polyvinyl pang'ono hydrolyzed 4.00 mg, titanium dioxide 2.35 mg, macrogol 3350 2.02 mg, talc 1.48 mg, utoto wa ayoni wachikasu 0.15 mg) .

Forsiga - mapiritsi okhala ndi filimu, 5 mg, 10 mg.

Mapiritsi 14 okhala ndi matuza a aluminium zojambulazo, matuza awiri kapena anayi mu bokosi la makatoni okhala ndi malangizo ogwiritsira ntchito, kapena mapiritsi 10 omwe ali ndi matuza a aluminiyamu zojambulazo, matuza atatu kapena 9 opangidwa mwa makatoni okhala ndi malangizo ogwiritsira ntchito.

Mankhwala Forsig ndi hypoglycemic wothandizira pakamwa, choletsa china cha 2 glucose transporter.

Dapagliflozin ndi potent (Kihibitilamu wosasinthika (Ki) wa 0,55 nM), mtundu wosankha-mtundu 2 wa glucose cotransporter inhibitor (SGLT2). SGLT2 imawonetsedwa m'magulu a impso ndipo sapezeka m'matumbo ena opitilira 70 (kuphatikizanso chiwindi, minofu yamatumbo, minofu ya adipose, gland ya mammary, chikhodzodzo, ndi ubongo). SGLT2 ndiye chonyamula chachikulu cha glucose reabsorption mu aimpso tubules. Glucose reabsorption mu aimpso tubules kwa odwala omwe ali ndi matenda a shuga 2 mellitus (T2DM) akupitiliza ngakhale hyperglycemia. Mwa kuletsa kusinthika kwa impso m'magazi, dapagliflozin imachepetsa kugwedezeka kwa impso tubules, zomwe zimapangitsa kuti shuga akhale impso. Zotsatira za dapagliflozin ndikuchepa kwa glucose othamanga ndipo mutatha kudya, komanso kuchepa kwa kuchuluka kwa hemoglobin ya glycosylated kwa odwala omwe ali ndi matenda a shuga a 2.

Kuchotsa glucose (glucosuric athari) kumachitika mutamwa mankhwala oyamba, umapitirira kwa maola 24 otsatira ndikupitilira chithandizo chonse. Kuchuluka kwa shuga komwe impso zimapangidwa chifukwa cha njirayi kumadalira kuchuluka kwa shuga m'magazi komanso kuchuluka kwa kusefedwa kwa glomerular (GFR). Dapagliflozin sichimasokoneza kupanga kwachilendo kwa glucose amkati poyankha hypoglycemia. Zotsatira za dapagliflozin ndizodziyimira payekha paz insulin komanso insulin sensitivity. M'maphunziro azachipatala a Forsig ™, kusintha kwa beta-cell kunadziwika (kuyesedwa kwa HOMA, kuwunika kwa homeostasis).

Kuwonongeka kwa shuga ndi impso zomwe zimayambitsidwa ndi dapagliflozin limodzi ndi kuchepa kwa zopatsa mphamvu komanso kuchepa kwa thupi. Dapagliflozin zoletsa wa sodium glucose cotransport limodzi ndi ofooka okodzetsa ndi osakhalitsa natriuretic zotsatira.

Dapagliflozin ilibe gawo lililonse kwa anthu ena omwe amayendetsa glucose omwe amatengera glucose kuzinthu zotumphukira ndikuwonetsa kupitirira 1,400 nthawi yayikulu pakusankha kwa SGLT2 kuposa SGLT1, transporter yayikulu yamatumbo yomwe imayendetsa mayamwidwe a glucose.

Atamwa dapagliflozin ndi odzipereka athanzi komanso odwala matenda amtundu wa 2, kuwonjezeka kwa glucose komwe anapatsidwa ndi impso kunawonedwa. Pamene dapagliflozin amatengedwa pa mlingo wa 10 mg / tsiku kwa masabata 12, mwa odwala T2DM, pafupifupi 70 g ya shuga patsiku idachotsedwa ndi impso (zomwe zimafanana ndi 280 kcal / tsiku). Odwala omwe ali ndi matenda a shuga a mtundu wa 2 omwe adatenga dapagliflozin pa 10 mg / tsiku kwa nthawi yayitali (mpaka zaka ziwiri), shuga wa mayamwidwe adasungidwa panthawi yonse ya mankhwala.

Kuchulukanso kwa shuga kwa impso ndi dapagliflozin kumathandizanso kuti osmotic diuresis ndi kuchuluka kwa mkodzo kuchuluka. Kuwonjezeka kwa kuchuluka kwa mkodzo kwa odwala omwe ali ndi matenda amtundu wa 2 akumamwa dapagliflozin pa 10 mg / tsiku lokhalokha kwa masabata 12 ndipo limafikira pafupifupi 375 ml / tsiku. Kuchuluka kwa kuchuluka kwa mkodzo kumayendera limodzi ndi kuchepa kwa pang'onopang'ono kwa impso, komwe sikunapangitse kusintha kwa kuchuluka kwa sodium mu seramu yamagazi.

Pambuyo pakukonzekera pakamwa, dapagliflozin imatengedwa mwachangu komanso kwathunthu m'matumbo am'mimba ndipo imatha kutengedwa nthawi yonse ya chakudya komanso kunja kwake. Kuchuluka kwa dapagliflozin m'madzi am'magazi (Stax) nthawi zambiri kumachitika mkati mwa maola 2 mutatha kudya. Makhalidwe a Cmax ndi AUC (dera lomwe lili pansi pa nthawi yopondera) amawonjezeka molingana ndi mlingo wa dapagliflozin. Mtheradi bioavailability wa dapagliflozin akaperekedwa pakamwa pa 10 mg ndi 78%. Kudya kunali ndi zolimbitsa pa pharmacokinetics ya dapagliflozin mwa odzipereka athanzi. Zakudya zamafuta kwambiri zimachepetsa Stax ya dapagliflozin ndi 50%, idakulitsa Ttah (nthawi yofika ndende yambiri ya plasma) pafupifupi ola limodzi, koma sizinakhudze AUC poyerekeza ndi kusala kudya. Kusintha kumeneku sikofunikira mwakuthupi.

Dapagliflozin pafupifupi 91% amamangidwa kumapuloteni. Odwala omwe ali ndi matenda osiyanasiyana, mwachitsanzo, omwe ali ndi vuto laimpso kapena kwa chiwindi, chizindikiro ichi sichinasinthe.

Dapagliflozin ndi glucoside yolumikizidwa ndi C yomwe aglycon yake imalumikizidwa ndi glucose ndi chomangira cha mpweya woipa (carbon-carbon bond), chomwe chimatsimikizira kukhazikika kwake pakulimbana ndi glucosidases. Wapakati wama plasma hafu ya moyo (T½) mwa odzipereka athanzi anali 12,9 patatha ola limodzi dapagliflozin pakamwa pa 10 mg. Dapagliflozin imapangidwa kuti ipange metabolite yosagwira kwambiri ya dapagliflozin-3-O-glucuronide.

Pambuyo pakamwa 50 mg ya 14C-dapagliflozin, 61% ya mlingo womwe unatengedwa umapangidwira dapagliflozin-3-O-glucuronide, womwe umakhala ndi 42% ya kuchuluka kwa plasma radioacaction (maola AUC0-12) - Mankhwala osasinthika amakhala ndi 39% ya kuchuluka kwa plasma ya plasma. Zigawo za metabolites zomwe zatsala payekhapayekha sizidutsa 5% ya kuchuluka kwa madzi am'magazi. Dapagliflozin-3-O-glucuronide ndi ma metabolites ena alibe mankhwala. Dapagliflozin-3-O-glucuronide imapangidwa ndi enzyme uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) omwe amapezeka m'chiwindi ndi impso, ndipo ma CYP cytochrome isoenzymes sakukhudzidwa ndi metabolism.

Dapagliflozin ndi ma metabolites ake amachotsedwa makamaka ndi impso, ndipo ndi ochepera 2% omwe amachotsedwa osasinthika. Mutatenga 50 mg ya 14C-dapagliflozin, 96% ya radioacaction idapezeka - 75% mkodzo ndi 21% mu ndowe. Pafupifupi 15% ya ma radioac opezeka mu ndowe adawerengedwa ndi dapagliflozin.

Kagayidwe ka dapagliflozin imachitika makamaka kudzera mu glucuronide conjugation mothandizidwa ndi UGT1A9.

Mu maphunziro a in vitro, dapagliflozin sizinatsekerere isoenzymes ya cytochrome P450 system CYP1A2, CYP2A6, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, ndipo sanalowetsetsetsetse. Mwakutero, zotsatira za dapagliflozin pakuvomerezeka kwa mankhwala ophatikizika omwe amakonzedwa ndi ma isoenzymes sikuyembekezeredwa.

Zizindikiro Forsig

Mankhwala a Forsig adapangidwira kuti agwiritsidwe ntchito mtundu wa 2 matenda a shuga kuphatikiza pa zakudya komanso kuchita masewera olimbitsa thupi kuti apititse patsogolo kulumikizana kwa glycemic monga: monotherapy, kuwonjezera pa mankhwala a metformin pokhapokha pakhale mokwanira kuwongolera glycemic pa mankhwalawa, poyambira kuphatikiza mankhwala ndi metformin, ngati mankhwalawa akuyenera.

Kodi mankhwala a Forsig amagwira ntchito bwanji

Zotsatira za mankhwala a Forsig zimatengera luso la impso kuti lisonkhanitse shuga m'magazi ndikuchotsa mkodzo. Mwazi m'thupi lathu umadetsedwa nthawi zonse ndi zinthu zopangidwa ndi metabolism komanso poizoni. Udindo wa impso ndikuwunika zinthu izi ndikuzichotsa. Chifukwa cha izi, magazi amadutsa mu mawonekedwe a impso kangapo patsiku. Pachigawo choyamba, zigawo zama protein zokha za magazi sizidutsa mu fayilo, madzi ena onse amalowa glomeruli. Izi ndiye zotchedwa kuti mkodzo woyamba, makumi a malita amapangidwa masana.

Kuti mukhale wachiwiri ndikulowa chikhodzodzo, madzi osefedwa amayenera kuzikirapo. Izi zimatheka mu gawo lachiwiri, pamene zinthu zonse zofunikira - sodium, potaziyamu, ndi zinthu zamagazi - zimatengedwanso m'magazi mu mawonekedwe osungunuka. Thupi limaganiziranso kuti shuga ndiyofunika, chifukwa ndi omwe amapatsa mphamvu minofu ndi ubongo. Mapuloteni apadera a SGLT2 amabweza magazi. Amapanga mtundu wamtunda mu thumba la nephron, lomwe shuga limadutsa m'magazi. Mwa munthu wathanzi, shuga amabweza kwathunthu; mwa wodwala yemwe ali ndi matenda ashuga, amalowa mkodzo pokhapokha mulingo wake umadutsa 9 9 mmol / L.

Mankhwala a Forsig adapezeka chifukwa chamakampani opanga mankhwala omwe amafunafuna zinthu zomwe zitha kutseka matanthwe amenewa ndikutchingira shuga mumkodzo. Kufufuza kunayambiranso m'zaka zapitazi, ndipo pomaliza, mu 2011, Bristol-Myers squibb ndi AstraZeneca anafunsanso kuti alembetsedwe ngati mankhwala atsopano a matenda a shuga.

Zomwe zimagwira ntchito ya Forsigi ndi dapagliflozin, ndizoletsa zama protein a SGLT2. Izi zikutanthauza kuti amatha kupondaponda ntchito yawo. Kuyamwa kwa glucose kuchokera mkodzo woyamba kumachepa, amayamba kuwonjezeredwa ndi impso mokulira. Zotsatira zake, kuchuluka kwa magazi kumatsitsa glucose, mdani wamkulu wamitsempha yamagazi ndi chifukwa chachikulu cha zovuta zonse za shuga. Mbali yodziwika bwino ya dapagliflozin ndiyosavuta kusankha, ilibe gawo lililonse pama glucose omwe amayenda ndi minofu ndipo samasokoneza mayamwidwe ake.

Pa mulingo woyenera wa mankhwalawa, pafupifupi 80 g ya shuga imatulutsidwa mkodzo patsiku, mopitilira kuchuluka kwa insulini yopangidwa ndi kapamba, kapena kupeza jakisoni. Zisakhudze kuchuluka kwa Forsigi ndi kukhalapo kwa insulin. Komanso, kuchepa kwa shuga m'magazi kumathandizira kudutsa kwa shuga otsala kudzera mu cell.

Momwe milandu amaikidwira

Forsyga sangathe kuchotsa shuga onse owonjezera ndi mafuta osamwa osagwirizana ndi chakudya. Monga othandizira ena a hypoglycemic, kudya ndi kuchita zolimbitsa thupi pakugwiritsa ntchito ndizofunikira. Nthawi zina, monotherapy ndi mankhwalawa ndizotheka, koma nthawi zambiri endocrinologists amalembera Forsig limodzi ndi Metformin.

Kukhazikitsidwa kwa mankhwala mu milandu yotsatirayi ndikulimbikitsidwa:

• kuwongolera kuchepa kwa odwala omwe ali ndi matenda a shuga a 2,
• Ngati njira yowonjezerapo ngati mukudwala kwambiri,
• kukonza zolakwika zazakudya nthawi zonse,
• pamaso pa matenda omwe amalepheretsa zolimbitsa thupi.

Pochiza matenda a shuga 1, mankhwalawa saloledwa, popeza kuchuluka kwa glucose omwe amagwiritsidwa ntchito ndi chithandizo chake ndikosiyanasiyana ndipo kumatengera zinthu zambiri. Ndikosatheka kuwerengera moyenera kuchuluka kwa insulini mumkhalidwe wotere, womwe umadzaza ndi hypo- ndi hyperglycemia.

Ngakhale adachita bwino kwambiri komanso kuwunika kwabwino, a Forsiga sanalandire zofalitsa zambiri. Pali zifukwa zingapo izi:

• mtengo wake wokwera
• nthawi yoperewera yophunzira,
• zimangokhudza chizindikiro cha matenda ashuga osakhudza zomwe zimayambitsa,
• zovuta za mankhwala.

Malangizo ogwiritsira ntchito mankhwalawa

Forsig amapezeka mu mawonekedwe a mapiritsi a 5 ndi 10 mg. Analimbikitsa tsiku lililonse mankhwala popanda contraindication nthawi zonse - 10 mg. Mlingo wa metformin amasankhidwa payekha. Matenda a shuga akapezeka, Forsigu 10 mg ndi 500 mg ya metformin nthawi zambiri amamulembera, pambuyo pake mlingo wa chomaliza umasinthidwa malinga ndi zomwe zikuwonetsa glucometer.

Zochita za piritsi zimatha maola 24, motero mankhwalawa amatengedwa 1 nthawi patsiku. Kuzindikira kwathunthu kwa Forsigi sikudalira kuti mankhwalawo adamwa pamimba yopanda kanthu kapena ndi chakudya. Chachikulu ndikumwa kumwa ndi madzi okwanira ndikuonetsetsa kuti pakhale Mlingo wofanana.

Mankhwala amakhudza kuchuluka kwamkodzo kwamkodzo tsiku lililonse, kuti muchepetse 80 g shuga, pafupifupi 375 ml ya madzi amathandizanso. Uwu ndi pafupifupi ulendo wina wowonjezera kuchimbudzi tsiku lililonse. Madzi otaika amayenera kulowedwa m'malo kuti athetse kusowa kwamadzi. Chifukwa chothetsa gawo lina la glucose mukamamwa mankhwalawo, zopatsa mphamvu zonse za kalori zimatsika ndi zopatsa mphamvu 300 patsiku.

Zotsatira zoyipa za mankhwalawa

Polembetsa Forsigi ku US ndi Europe, opanga ake adakumana ndi zovuta, komitiyi sinavomereze mankhwalawo chifukwa choopa kuti ikhoza kuyambitsa zotupa mu chikhodzodzo. Panthawi ya mayeso azachipatala, malingaliro awa adakanidwa, katundu wa carcinogenic sanawululidwe ku Forsigi.

Pakadali pano, pali zambiri kuchokera ku kafukufuku woposa khumi ndi awiri yemwe watsimikizira chitetezo cha mankhwalawa komanso kuthekera kwake kuchepetsa shuga. Mndandanda wazotsatira zoyipa ndi kupezeka kwa zomwe zimachitika zimapangidwa. Zonse zomwe atengedwa zimachokera pakudya kwakanthawi kothana ndi Forsig - pafupi miyezi isanu ndi umodzi.

Palibe deta pazotsatira zakugwiritsa ntchito mankhwalawa kwa nthawi yayitali. Akatswiri a Nephrologists ati akuda nkhawa kuti kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kungasokoneze kugwira ntchito kwa impso. Chifukwa choti amakakamizidwa kuti azigwira ntchito mopitilira muyeso, kuchuluka kwa kusefera kwa madzi kumatha kuchepa ndipo kuchuluka kwa mkodzo kumatha kuchepa.

Zotsatira zoyipa zomwe zadziwika:

1. Mukapatsidwa chida chowonjezera, kuchepa kwambiri kwa shuga m'magazi ndikotheka. Hypoglycemia nthawi zambiri imakhala yofatsa.
2. Kutupa kwa genitourinary system yoyambitsidwa ndi matenda.
3. Kuchulukitsa kwamkodzo kwamkodzo ndi zochuluka kuposa kuchuluka kwake kochotsa glucose.
4. Kuchuluka kwa lipids ndi hemoglobin m'magazi.
5. Kukula kwa magazi a metabolinine komwe kumayenderana ndi kuwonongeka kwa impso kwa odwala omwe ali ndi zaka 65.

Osakwana 1% odwala omwe ali ndi matenda ashuga, mankhwala amayambitsa ludzu, kuchepa kwa nkhawa, kudzimbidwa, thukuta lomwe limachitika kawirikawiri.

Kukhala tcheru kwakukulu kwa madokotala kumachitika chifukwa cha kukula kwa matenda opatsirana kwamtunduwu chifukwa chogwiritsa ntchito Forsigi. Zotsatira zamtunduwu ndizofala kwambiri - mwa 4.8% ya odwala matenda a shuga. Amayi 6.9% ali ndi vaginitis ya bakiteriya ndi fungus komwe amayambira. Izi zikufotokozedwa ndikuti shuga yowonjezereka imakwiyitsa kuchuluka kwa mabakiteriya mu urethra, mkodzo ndi nyini. Kuteteza mankhwalawa, titha kunena kuti matendawa amakhala ochepetsetsa kapena ochepa komanso amathandizira pakulandira chithandizo chokwanira. Nthawi zambiri zimachitika kumayambiriro kwa Forsigi, ndipo sizibwerezedwanso kuthandizidwa.

Malangizo ogwiritsira ntchito mankhwalawa amasintha mosinthasinthazimagwirizanitsidwa ndi kupezeka kwa zotsatira zoyipa ndi contraindication.Mwachitsanzo, muFebruary 2017, chenjezo lidaperekedwa kuti kugwiritsa ntchito SGLT2 inhibitors kumawonjezera chiopsezo chodulidwa zala zakumanzere kapena mbali ya phazi nthawi ziwiri. Zosinthidwa zimawonekera mumayendedwe a mankhwalawo mutatha maphunziro atsopano.

Forsiga: malangizo ogwiritsira ntchito, mtengo, ndemanga ndi fanizo

Mankhwala "Forsiga" adakhala chida chogwiritsidwa ntchito mogwirizana ndi malangizo omwe angagwiritsidwe ntchito pochiza matenda a shuga 2. Kutengedwa pakamwa, kumakulitsa kuchuluka kwa shuga m'thupi, motero kumachepetsa mulingo wake m'magazi.

Contraindication Forsigi

Zoyipa zotsutsana ndi:

1. Type 1 shuga mellitus, popeza kuthekera kwa hypoglycemia kwakukulu sikumachotsedwa.
2. Nthawi ya kubereka ndi mkaka wa m`mawere, zaka mpaka 18. Umboni wa chitetezo cha mankhwalawa kwa amayi apakati ndi ana, komanso kuthekera kwa kutulutsa kwake mkaka wa m'mawere, sikunachitike.
3. Zazaka zopitilira 75 chifukwa cha kuchepa kwa thupi mu ntchito ya impso komanso kuchepa kwa magazi mozungulira.
4. Lactose tsankho, ngati chinthu chothandizira ndi gawo la piritsi.
5. Thupi lawo siligwiritsidwa ntchito popanga miyala ya zipolopolo.
6. Kuchulukitsa kwamphamvu m'magazi a ketone matupi.
7. Matenda a shuga ndi nephropathy omwe amachepetsa kuchepa kwa kusefukira kwa 60 ml / mphindi kapena kulephera kwambiri kwaimpso komwe sikugwirizana ndi shuga.
8. Kulandilidwa kwa malupu (furosemide, torasemide) ndi thiazide (dichlothiazide, polythiazide) okodzetsa chifukwa cha kuchuluka kwa zomwe amachita, zomwe zimayamba chifukwa chakuchepa kwa kupsinjika ndi kuperewera kwa madzi m'thupi.

Kuvomerezedwa kumaloledwa, koma kusamala ndikuwonetsetsa madokotala owonjezera amafunikira: odwala okalamba omwe ali ndi matenda osokoneza bongo, anthu omwe ali ndi hepatic, mtima kapena kufooka kwa aimpso, matenda osachiritsika.

Doctor of Medical Science, Mutu wa Institute of Diabetesology - Tatyana Yakovleva

Ndakhala ndikuphunzira matenda a shuga kwa zaka zambiri. Zimakhala zowopsa anthu ambiri akamwalira, ndipo makamaka amakhala olumala chifukwa cha matenda ashuga.

Ndithamangira kunena mbiri yabwino - Endocrinological Research Center ya Russian Academy of Medical Sayansi yakwanitsa kupanga mankhwala omwe amachiritsa odwala matenda ashuga mellitus. Pakadali pano, kugwiritsa ntchito bwino kwa mankhwalawa kuyandikira 98%.

Nkhani ina yabwino: Unduna wa Zaumoyo wateteza kukhazikitsidwa kwa pulogalamu yapadera yomwe imalipira mtengo wa mankhwalawo. Ku Russia, odwala matenda ashuga mpaka Meyi 18 (kuphatikiza) nditha kuipeza - Kwa ma ruble 147 okha!

Kuyesedwa kwa zovuta zakumwa zoledzeretsa, nikotini ndi zakudya zosiyanasiyana zomwe zimachitika chifukwa cha mankhwala sikunachitikebe.

Kodi zingathandize kuti muchepetse kunenepa

Pakufotokozeratu mankhwalawo, wopanga Forsigi amadziwitsa za kuchepa kwa thupi komwe kumawonedwa pakumwa. Izi zimadziwika makamaka kwa odwala matenda a shuga omwe amakhala ndi kunenepa kwambiri. Dapagliflozin amagwira ntchito monga okodzetsa pang'ono, amachepetsa kuchuluka kwa madzi mthupi. Ndilemera kwambiri komanso kupezeka kwa edema, awa ndi madzi osachepera 3-5 kg ​​sabata yoyamba. Zofananazo zitha kuchitika mwa kusinthira ku chakudya chopanda mchere ndikuchepetsa kwambiri kuchuluka kwa chakudya - thupi limayamba kuchotsa chinyezi chomwe silikufunika.

Chifukwa chachiwiri chakuchepetsa thupi ndi kuchepa kwama calories chifukwa kuchotsedwa kwa gawo la shuga. Ngati 80 g ya glucose imatulutsidwa mkodzo patsiku, izi zimataya kuchepa kwa zopatsa mphamvu 320. Kuti muchepetse kilogalamu yakulemera chifukwa cha mafuta, muyenera kuchotsa ma calories a 7716, ndiye kuti, kutaya kilogalamu imodzi kumatenga masiku 24. Zikuwonekeratu kuti Forsig angachite pokhapokha ngati pali zakudya zopanda thanzi. Kuti mukhale okhazikika, kuchepa thupi kuyenera kutsatira zakudya zomwe simukudwala ndipo musaiwale za maphunziro.

Anthu athanzi sayenera kugwiritsa ntchito Forsigu pakuchepetsa thupi. Mankhwalawa amagwira ntchito kwambiri ndi misempha yayikulu yamagazi. Kuyandikira kwambiri kwachilendo, kumachepetsa mphamvu ya mankhwalawo. Musaiwale za kupsinjika kwakukulu kwa impso ndi chidziwitso chosakwanira pakugwiritsa ntchito mankhwalawa.

Forsyga imangopezeka ndi mankhwala okha ndipo imangoperekedwa kwa odwala omwe ali ndi matenda a shuga a 2.

Ndemanga za Odwala

The endocrinologist adangolembera Forsig ndi chakudya kwa ine, koma ndi lingaliro kuti ndizitsatira mosamalitsa malamulo ndikupita kumaphwando nthawi zonse. Glucose m'magazi anachepa bwino, mpaka masiku 7 mwa 10. Tsopano patha miyezi isanu ndi umodzi, sindinapatsidwe mankhwala ena, ndikumva bwino, ndataya 10 kg panthawiyi. Tsopano pang'onopang'ono: Ndikufuna kuti ndichepetse chithandizo ndikuwona ngati nditha kupitiliza shuga ndekha, pakudya kokha, koma adokotala samalola.

Kodi fanizo ndi chiyani

Mankhwala a Forsig ndi mankhwala okhawo omwe amapezeka m'dziko lathu ndi dapagliflozin. Zofananira zonse za Forsigi choyambirira sizipangidwa. Monga cholowa mmalo, mutha kugwiritsa ntchito mankhwala aliwonse kuchokera mgulu la ma glyphosins, machitidwe omwe amatengera zoletsa za SGLT2. Mankhwala awiri otere adapereka kulembetsa ku Russia - Jardins ndi Invokana.

Makampani a Bristol Myers squibb, USA

AstraZeneca UK Ltd, UK

Mitengo yoyenerera ya Forsigu

Mwezi umodzi wothira mankhwala Forsig udzagula pafupifupi ma ruble 5,000. Kunena zowona, sikotsika mtengo, makamaka mukamaganizira za omwe ali ndi mavitamini ofunikira, mavitamini, zotsekemera za glucometer, ndi m'malo mwa shuga, zomwe ndizofunikira kwa odwala matenda ashuga. Posachedwa, zinthu sizingasinthe, popeza mankhwalawo ndi atsopano, ndipo wopanga amafuna kuyambiranso ndalama zomwe adaziika pantchito zachitukuko ndi kafukufuku.

Kuchepetsa kwa mitengo kungayembekezeredwe pokhapokha kutulutsidwa kwa ma jenetiki - ndalama ndi zomwe zimapangidwa ndi ena opanga. Otsutsana nawo otsika mtengo sawonekera pofika chaka cha 2023, chitetezo cha patent cha Forsigi chikadzatha, wopanga zinthu zoyambirira ataya ufulu wake wapadera.

Onetsetsani kuti mwaphunzira! Kodi mukuganiza kuti kuyamwa kwa mapiritsi ndi insulini kwa nthawi yonse yokhayo ndi njira yokhayo yothanirana ndi shuga? Sichowona! Mutha kutsimikizira izi nokha ndikuyamba kuzigwiritsa ntchito. werengani zambiri >>

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Amapezeka m'mawonekedwe amtundu wa mapiritsi wokhala ndi zokutira kwamafuta achikasu, 5 ndi 10 mg yogwira ntchito. Biconvex woyamba, amakhala ndi mawonekedwe ozungulira, mbali imodzi - olembedwa "5", ndi ena - "1427". Lachiwiri - maumboni olembedwa "10" ndi "1428".

Chofunika chachikulu pa mankhwala ndi propanediol dapagliflozin monohydrate.

• cellcrystalline mapadi,
• michere ya m'magazi,
• magnesium wakuba,
• silika.

Chigoba cha mapiritsi: Opadray® II chikasu (mowa wa polyvinyl pang'ono wokhala ndi hydrolyzed, titanium dioksidi, macrogol, talc, utoto wachikasu wachitsulo).

Mapiritsi 10 ali ndi matuza a zojambulazo, zomwe zimayikidwa mkatoni mwa atatu.

Malangizo ogwiritsira ntchito phukusi lililonse.

Zotsatira za pharmacological

Yogwira gawo la dapagliflozin imaperekanso shuga m'mitsempha, ngati wodwalayo ali ndi vuto lalikulu la hyperglycemia. Pansi pa kuchitapo kwake, kufalikira kwa shuga ndi impso kumachepetsa, kotero kuti umathiridwa mkodzo. Kuchuluka kwa shuga mu mkodzo mutatha kumwa mankhwalawa zimatengera kuchuluka kwa kuchuluka kwa impso ndi shuga.

Kuchuluka kwa insulini yopangidwa ndi kapamba komanso chidwi cha minyewa yake sizikhudza zotsatira za kugwiritsa ntchito mankhwalawa. Mothandizidwa ndi mankhwalawa, kuchuluka kwa mkodzo wotulutsidwa kumawonjezeka. Izi zimachitika chifukwa chachilendo chochotsa shuga m'thupi pogwiritsa ntchito impso.

Forsiga samasokoneza kagayidwe kazakudwala mu ziwalo zina. Ndi kudya pafupipafupi, kuchepa kwa kuthamanga kwa magazi ndi magawo a 1.5-2 a mercury amadziwika. Kuchuluka kwa shuga m'magazi kumatsika ndi 3-4%. Kutsika kwa ndende yamagazi kumachitika mosasamala kanthu za chakudya.

Kutulutsa kowonjezera kwa glucose kuchokera mthupi kumayamba pambuyo pa mlingo woyamba wa mankhwalawa ndikupitilira tsiku limodzi. Kumapeto kwa maphunzirowo, kuchuluka kwa glucose womasulidwa kumachepa.

Pharmacokinetics

Dapagliflozin imalowa m'matumbo athunthu. Kutenga mankhwalawo ndi chakudya kapena palokha sikukhudza mayendedwe ake. Kuchuluka kwazinthu kumawonekera pambuyo maola awiri, ngati kudya kunali pamimba yopanda kanthu. Bioavailability ukufika 78%. Mlingo wa kumangiriza zinthu kuti uzisungika m'madzi a m'magazi ndi 91%. Mtengo wake sukusinthika pakumenyedwa kwa kuphwanya kwa ntchito kwa impso ndi chiwindi.

Hafu ya moyo wa thupi ndi maola 13. Kutupa mu mawonekedwe okhudzana ndi shuga kumachitika ndi impso. 2% yokha ya ndalamazi ndi yomwe singasinthe.

Chizindikiro chogwiritsira ntchito mankhwalawa ndi mtundu 2 shuga. Amagwiritsidwa ntchito ngati kuwonjezera pa zakudya ndi physiotherapy ngati sangapereke zotsatira zokwanira. Amaloledwa kumwa mankhwalawo nthawi yomweyo ngati jakisoni wa metformin kapena insulin.

Pakatha milungu iwiri, odwala amawonetsedwa kuti apereke magazi kuti adziwe kuchuluka kwa shuga. Ngati kusintha kwabwino kumawonedwa, ndiye kuti chithandizo chamankhwala chimapitirirabe. Pakakhala kusintha, mapiritsi amatengedwa kwa masiku 14 ena ndikuwonjezedwanso. Malinga ndi zotsatira zake, momwe ntchito ya thupilo imagwirira ntchito pa thupi ndi kufunika kogwiritsanso ntchito zimatsimikizika.

Malangizo ogwiritsira ntchito (mlingo)

Mankhwala odziwika bwino a shuga ndi 10 mg. Mlingo wa 5 mg umagwiritsidwa ntchito kumayambiriro kwa maphunzirowo kuti azolowere pang'onopang'ono komanso kupewa kupewa kuwopsa ndi nkhanza. Komanso, mlingo wochepetsedwa ndi wofunikira ngati ntchito ya impso ikulephera kapena wodwala wamkulu kuposa zaka 75. Nthawi yakudya siyimakhudza mphamvu ya mankhwalawa.

Kuyambitsa mankhwala ndi kuphatikiza kugwiritsa ntchito mankhwalawa kumapangidwa motere: m'mawa, kudya kwa Forsigi 10 mg, madzulo, kugwiritsa ntchito metformin 500 mg.

Chizolowezi chodzidzimutsa ndi kamodzi pa tsiku la 10 mg, yokhayo kaphatikizidwe ndi insulin.

Bongo

Munthawi yabwinobwino ya impso popanda zotsatira zoyipa zaumoyo, munthu amalekerera kuchuluka kwa 500 mg. Mankhwala atatha kulowa mthupi, kupezeka kwa glucose wambiri mumkodzo amalembedwa masiku 5-6. Kuthetsa madzi kumbuyo kwa chodabwachi sikunawonedwe mwa zamankhwala.

Vuto la mankhwala osokoneza bongo, wodwalayo amafunika kuyang'aniridwa ndi wodwala pafupipafupi. 3% yokha mwa odwala omwe ali ndi mankhwala osokoneza bongo omwe amafunikira chithandizo chamankhwala. Kwa ena onse, chithandizo chothandizira chimakhala chokwanira.

Kuyanjana kwa mankhwala osokoneza bongo

"Forsiga" imawonjezera zochita za okodzetsa. Chifukwa cha izi, wodwalayo amatha kuyamba kuchepa magazi komanso kuchepa kwambiri kwa magazi. Pazifukwa izi, mankhwala osakanikirana.

Kugwiritsa ntchito pamodzi ndi mankhwala omwe zochita zawo zimafuna kuwonjezera mapangidwe a insulin, pamakhala ngozi ya hypoglycemia.

Malangizo apadera

Asanaperekane, wodwalayo amafunika kumuwunika bwinobwino, momwe impso zake zidzakhazikitsidwe. Pambuyo pakuyamba chithandizo, kafukufuku wofanana amachitika miyezi isanu ndi umodzi iliyonse. Ngati kupatuka koipitsitsa kupezeka, ndiye kuti pali mankhwala atsopano.

Pa chithandizo, simuyenera kuchita nawo ntchito zoopsa zomwe zimafuna kuti anthu azichita mofulumira komanso aziganiza, komanso magalimoto oyendetsa. Mankhwalawa angayambitse chizungulire zingapo mwa odwala.

Fananizani ndi fanizo

Ivan: "Forsiga" samachepetsa kwambiri shuga, koma kupsinjika kumatsika moonekeratu. The endocrinologist adandiuza kuchuluka kwa 5 mg kwa ine. Pakatha mwezi umodzi chithandizo, mankhwalawa adasinthidwa ndi ena chifukwa chofooka. Sindinazindikire kuphwanyidwa kwa chiwonetsero cha zochita ndikuchepa kwa chidwi. "

Irina: “Mwina uku ndikumvetsetsa kwanga, koma mankhwala anga adandipangitsa kuchuluka kwa shuga. Osati izi zokha, kuyabwa kosaletseka kunawonekera pamalo apafupi ndi urethra, malungo ndi kupumira movutikira. Dokotalayo anachotsa mankhwalawo mwachangu. Pepani ndalama zomwe mwawononga. "

Elena: “Forsiga ndiyenera. Amatha kuyimitsa jakisoni wa insulin. Amamva bwino kwakanthawi. Kumayambiriro kwa maphunzirowa, cystitis imachulukirachulukira chifukwa cha kuchuluka kwa impso. Ndidayenera kumuchitira. Panalibe zovuta zina ndi chikhodzodzo. ”

Forsiga ndi mankhwala osokoneza bongo omwe amagwiritsidwa ntchito pochiza matenda a shuga 2.

Chida chachikulu chogwira - Dapagliflozin - chimathandizira kuthamangitsa shuga m'thupi ndi impso, kutsitsa njira yolowera kugwiranso kwa shuga m'magazi a impso.

Kukhazikika kwa chochitika cha mankhwalawa kumawonedwa mutatenga mlingo woyamba wa Forsigi, kuchuluka kwa glucose kumapitirira kwa maola 24 otsatira ndipo kumapitilira nthawi yonse ya chithandizo. Kuchuluka kwa shuga komwe impso zimatulutsa kumadalira kuchuluka kwa kusefedwa kwa magazi (GFR) ndi msempha wamagazi.

Chimodzi mwazabwino za mankhwalawa ndikuti Forsig amachepetsa mphamvu ya shuga ngakhale wodwalayo awonongeka ndi kapamba, zomwe zimayambitsa kuphedwa kwa maselo ena a β-cell kapena kukula kwa minofu yotsutsa insulini.

Mankhwala

Zotsatira za mankhwala a Forsig zimatengera luso la impso kuti lisonkhanitse shuga m'magazi ndikuchotsa mkodzo. Mwazi m'thupi lathu umadetsedwa nthawi zonse ndi zinthu zopangidwa ndi metabolism komanso poizoni.

Udindo wa impso ndikuwunika zinthu izi ndikuzichotsa. Chifukwa cha izi, magazi amadutsa mu mawonekedwe a impso kangapo patsiku. Pachigawo choyamba, zigawo zama protein zokha za magazi sizidutsa mu fayilo, madzi ena onse amalowa glomeruli.

Izi ndiye zotchedwa kuti mkodzo woyamba, makumi a malita amapangidwa masana.

Kuti mukhale wachiwiri ndikulowa chikhodzodzo, madzi osefedwa amayenera kuzikirapo. Izi zimatheka mu gawo lachiwiri, pamene zinthu zonse zofunikira - sodium, potaziyamu, ndi zinthu zamagazi - zimatengedwanso m'magazi mu mawonekedwe osungunuka.

Thupi limaganiziranso kuti shuga ndiyofunika, chifukwa ndi omwe amapatsa mphamvu minofu ndi ubongo. Mapuloteni apadera a SGLT2 amabweza magazi. Amapanga mtundu wamtunda mu thumba la nephron, lomwe shuga limadutsa m'magazi.

Mwa munthu wathanzi, shuga amabweza kwathunthu; mwa wodwala yemwe ali ndi matenda ashuga, amalowa mkodzo pokhapokha mulingo wake umadutsa 9 9 mmol / L.

Mankhwala a Forsig adapezeka chifukwa chamakampani opanga mankhwala omwe amafunafuna zinthu zomwe zitha kutseka matanthwe amenewa ndikutchingira shuga mumkodzo. Kufufuza kunayambiranso m'zaka zapitazi, ndipo pomaliza, mu 2011, Bristol-Myers squibb ndi AstraZeneca anafunsanso kuti alembetsedwe ngati mankhwala atsopano a matenda a shuga.

Zomwe zimagwira ntchito ya Forsigi ndi dapagliflozin, ndizoletsa zama protein a SGLT2. Izi zikutanthauza kuti amatha kupondaponda ntchito yawo. Kuyamwa kwa glucose kuchokera mkodzo woyamba kumachepa, amayamba kuwonjezeredwa ndi impso mokulira.

Zotsatira zake, kuchuluka kwa magazi kumatsitsa glucose, mdani wamkulu wamitsempha yamagazi ndi chifukwa chachikulu cha zovuta zonse za shuga.

Mbali yodziwika bwino ya dapagliflozin ndiyosavuta kusankha, ilibe gawo lililonse pama glucose omwe amayenda ndi minofu ndipo samasokoneza mayamwidwe ake.

Pa mulingo woyenera wa mankhwalawa, pafupifupi 80 g ya shuga imatulutsidwa mkodzo patsiku, mopitilira kuchuluka kwa insulini yopangidwa ndi kapamba, kapena kupeza jakisoni. Zisakhudze kuchuluka kwa Forsigi ndi kukhalapo kwa insulin. Komanso, kuchepa kwa shuga m'magazi kumathandizira kudutsa kwa shuga otsala kudzera mu cell.

Kodi ndizotheka kuchepetsa thupi ndi Forsiga?

Mu malangizo a mankhwalawa, wopanga amawonetsa kuchepa kwa thupi komwe kumawonedwa pakumwa. Izi zimadziwika kwambiri kwa odwala omwe alibe matenda a shuga okha, komanso kunenepa kwambiri.

Chifukwa cha diuretic katundu, mankhwalawa amachepetsa kuchuluka kwa madzi mthupi. Kuthekera kwa zigawo zina za mankhwala kuphatikiza gawo la glucose kumathandizanso kuchepa kwa mapaundi owonjezera. Mikhalidwe yayikulu yokwaniritsira kugwiritsa ntchito mankhwalawa ndiyosakwanira kudya komanso kuyambitsa zoletsa pazokhazokha malinga ndi zakudya zomwe zaperekedwa.

Anthu athanzi sayenera kugwiritsa ntchito mapiritsiwa kuti muchepetse kunenepa. Izi zimachitika chifukwa cha kuchuluka kwa impso, komanso kusadziwa bwino kwa Forsigi.

Forsiga: malangizo ogwiritsira ntchito. Momwe mungatengere m'malo mwake

Forsiga ndi m'badwo waposachedwa kwambiri wa matenda ashuga a 2. Dziwani zonse zomwe mukufuna za iye. The yogwira ndi dapagliflozin. Pansipa mupeza malangizo ogwiritsira ntchito olembedwa m'chinenerochi. Werengani zikuwonetsa, contraindication, Mlingo ndi zoyipa. Mvetsetsani momwe mungatengere mapiritsi a Forsig komanso momwe imagwirizanirana ndi njira zina zodziwika bwino za matenda ashuga.

Werengani komanso zamankhwala othandizira omwe amasunga shuga 3.9-5,5 mmol / L khola maola 24 patsiku, monga momwe zimakhalira ndi anthu athanzi. Dongosolo la Dr. Bernstein, wokhala ndi vuto la glucose metabolism kwa zaka zopitilira 70, limakupatsani mwayi wodziteteza ku zovuta zowopsa. Mwatsatanetsatane, onani njira yothandizira odwala matenda ashuga amtundu 2.

Chithandizo cha Matenda a Forsig Type 2 a shuga: Nkhani Yotsimikizika

Tsambali likuti zabwino - Forsig kapena Jardins, ndizotheka kuphatikiza mankhwalawa ndi mowa kuposa momwe zingasungidwire m'malo a mankhwalawa a matenda ashuga a 2.

Zomwe zili bwino: Forsiga kapena Jardins?

Panthawi yolemba izi, padalibe zambiri zokhudzana ndi kuchuluka kwa mphamvu ya mankhwala a Forsig ndi Jardins.

Mapiritsi a Forsig adagulitsidwa kale kuposa a Jardins, ndipo adakwanitsa kale kutchuka pakati pa odwala omwe ali ndi matenda ashuga. Patsamba lolankhula ku Russia mutha kupeza ndemanga zambiri za mankhwala a Forsig kuposa mankhwala Jardins.

Koma izi sizitanthauza kuti Forsig amatsitsa shuga pamwazi kuposa Jardins. Mwambiri, mankhwalawa onse amachita chimodzimodzi.

Forsyga ndi wotsika mtengo pang'ono kuposa a Jardins. Pali odwala ambiri omwe mtundu wa 2 shuga umakhala wovuta chifukwa cha kulephera kwapakati pamitsempha ndi kusefukira kwa gawo la 45-60 ml / min.

Mankhwala Forsig amatsutsana mu odwala matenda ashuga. Mwina adotolo angaganize kuti Jardins atha kutengedwa mosamala komanso moyang'aniridwa ndi achipatala.

Ngati vuto la impso likulephera, musatchule mankhwala, dokotala.

Tsamba la endocrin-patient.com silikulimbikitsa kumwa Forsig kapena Jardins. M'malo momwa mapiritsi amtengo wapatali awa, phunzirani njira zamankhwala zotsatila za matenda ashuga a 2 ndikuchitapo kanthu. Mutha kusunga shuga wabwinobwino wopanda magazi kuti mupewe matenda obwera mkodzo.

Kumbukirani kuti pyelonephritis (matenda opatsirana impso) ndi tsoka. Mpaka pano, ndizosatheka kuti munthu apezenso matendawa. Maantibayotiki amapereka mphamvu yochepa komanso yofooka. Pyelonephritis amafupikitsa moyo wa odwala ndikuwonjezanso mtundu wake. Kulephera kwa impso komanso kuyimba modutsa ndiye chovuta kwambiri chomwe chingakuchitikireni.

Ndikwabwino kuchita popanda kuchotsera shuga mumkodzo, kuti musakuwonjezere chiopsezo chotere.

Maso (retinopathy) Impso (nephropathy) Matenda a shuga Atsitsi: miyendo, mafupa, mutu

Momwe mungamwe mankhwala a Forsig

Monga tafotokozera pamwambapa, ndibwino kuti musamwe konse mankhwalawa. Tsamba la endocrin-patient.com limakuphunzitsani momwe mungawongolere matenda amtundu wa 2 osamwa mapiritsi owopsa komanso okwera mtengo, kusala kudya, komanso kubaya jekeseni wamkulu wa insulin. Palibe chifukwa chomwa mapiritsi a Forsig, chifukwa muli ndi njira zambiri komanso zotetezeka zothetsera shuga zamagazi kuti zisasunthike komanso zabwinobwino.

Ngati mukufunabe kumwa dapagliflozin, funsani dokotala wanu kuti adziwe kuti muyambire pati - 5 kapena 10 mg.

Anthu omwe ali ndi matenda ashuga omwe amamwa jakisoni kapena amamwa mankhwala a sulfonylurea (Mankhwala a Diabeteson MV, Maninil, Amaril ndi ofanana) amafunika kuchepetsa mwachangu kuchuluka kwa mankhwalawa kuti hypoglycemia isachitike. Ndikwabwino kuchita izi moyang'aniridwa ndi dokotala.

Ndikulimbikitsidwa kuti muchepetse muyeso ndi malire, kenako ndikuwonjezera pang'onopang'ono molingana ndi shuga.

Zipatso Bee uchi Porridge Batala ndi masamba mafuta

Kodi ndingathe kumwa mapiritsi a Forsig ndi jakisoni wa insulin?

Tsambali limafotokoza zovuta zomwe zimapezeka chifukwa cha mankhwala a Forsig ndi mawonekedwe ake. Kuyesa kuchiza odwala matenda ashuga ndi mapiritsi awa kumatha kukhala vuto lalikulu. Chiwerengero cha chiwopsezo ndi kupindula ndizochepa kwambiri.

M'malo mongomwa mankhwala okwera mtengo, ndibwino kuti muchepetse shuga wabwinobwino wokhala ndi zakudya zamafuta ochepa. Pa matenda akuluakulu a shuga, ngakhale jakisoni wochepa wa insulin angafunike. Nkhani yoti "Insulin yokhala ndi matenda a shuga a mtundu wachiwiri: zabwino ndi zowonongeka" ndi yothandiza kwa inu.

Kodi mapiritsiwa amagwirizana ndi mowa?

Palibe chidziwitso chokwanira momwe mankhwala a Forsig alili ogwirizana ndi mowa. Malangizo oyendetsedwa ndi funsoli adutsa mwakachetechete. Kumwa dapagliflozin, mudzagwiritsa ntchito ngakhale mlingo wochepa wa mowa pangozi yanu.

Mutha kuphunzira kuti, “Mowa wa Matendawa.” Ili ndi zambiri zosangalatsa. Ikutchula zakumwa za mowa zomwe zimawonedwa ngati zopanda vuto kwa amuna ndi akazi. Koma palibe chitsimikizo chomwe chingapatsidwe kuti amakhala otetezeka ku maziko a chithandizo cha Forsig.

Zowona zokwanira ndi kugwiritsa ntchito mankhwalawa sizinapezeke.

Chingalowe m'malo dapagliflozin ndi chiyani?

Otsatirawa akufotokoza momwe dapagliflozin ingasinthidwe m'malo otsatirawa:

• Mankhwalawa samachepetsa shuga m'magazi odwala matenda ashuga.
• Mankhwala ndi okwera mtengo kwambiri, munthu sangakwanitse.
• Mapiritsi amathandizira, koma odwala matenda ashuga sakufuna kudziwonetsa yekha pazotsatira zawo.

Mankhwala a Forsig ndi fanizo lake amachepetsa shuga ngakhale kwa odwala matenda ashuga omwe samapanga insulin yawo yonse. Komabe, kugwiritsa ntchito chida ichi kungakhale kosakwanira, shuga amakhalabe apamwamba, makamaka mukatha kudya.

Mwawerenga pamwambapa momwe zovuta zoyambitsa dapagliflozin zimayambira. Mwina mwasankha kuti muyenera kumuyang'ana m'malo mwake. Odwala ambiri sangathe kugula mankhwalawa, makamaka kwa odwala matenda ashuga.

Munthawi zonsezi, mutha kupita ku chithandizo chamankhwala a matenda ashuga a 2. Sichifuna kudya mapiritsi owopsa komanso okwera mtengo, kusala kudya kapena kulimbikira.

Zowona, pamavuto ovuta kwambiri, muyenera kulumikiza jakisoni wa insulin mu Mlingo wochepa. Koma shuga amakhalanso bwino maola 24 patsiku.

Mutha kukhala ndi moyo mpaka ukalamba kwambiri, kutsekereza kukula kwa zovuta za matenda ashuga.

Kodi ndingathe kumwa mapiritsi a Forsig aanthu athanzi?

Palibe phindu kwa anthu athanzi kuti atenge mapiritsi a Forsig kuti achepetse thupi. Mankhwalawa amachotsa shuga ndi ma calories m'thupi ndi mkodzo pomwe kuchuluka kwa shuga m'magazi kuli pamwamba pa 7-8 mmol / L. Komabe, mwa anthu athanzi, shuga magazi samangofika pachilumbachi. Chifukwa chake, mankhwalawa Forsig samachita pa iwo.

Samalani mapiritsi a metformin. Amathandizira kuchepa thupi, pomwe amakhala okwera mtengo komanso otetezeka kwambiri. Umu ndi mankhwala ovomerezeka omwe amagulitsidwa ku malo ogulitsira mankhwala, osati mtundu wina wowonjezera zakudya wamankhwala. Amavomerezeka ngakhale ndi dotolo wodziwika komanso wowonetsa TV: Elena Malysheva.

Zolemba zogwiritsira ntchito

Anthu okalamba odwala matenda ashuga nthawi zambiri amakhala ndi vuto la impso, amayenera kugwiritsa ntchito mankhwala a antihypertensive omwe amakhudza ntchito ya mbolo molingana ndi mfundo ya ACE inhibitors.

Kwa okalamba, njira zomwezi zimagwiritsidwanso ntchito ngati kufooka kwa impso m'magulu ena a odwala matenda ashuga. Kwa odwala omwe ali ndi zaka zopitilira 65, mavuto a impso nthawi zina amapezeka chifukwa cha dapagliflozin.

Zotsatira zoyipa zomwe zimachitika chifukwa chakufooka kwa ziwalo zophatikizika ndikuwonjezera kwa creatinine.

Pochiza matenda a shuga kunyumba, akatswiri akulangizani DiaLife. Ichi ndi chida chapadera:

• Amasinthasintha shuga
• Amayang'anira ntchito ya pancreatic
• Chotsani puffness, limayendetsa madzi kagayidwe
• Amawongolera masomphenya
• Zoyenera akulu ndi ana.
• Alibe zotsutsana

Opanga alandila ziphaso zonse zofunika ndi ziphaso za mbiri ku Russia komanso m'maiko oyandikana.

Timapereka kuchotsera kwa owerenga tsamba lathu!

Gulani pa tsamba lovomerezeka

Akatswiri sanaphunzire kugwiritsa ntchito mankhwala Forsig pa nthawi yomwe ali ndi pakati, choncho mankhwala amatsutsana ndi omwe ali ndi matenda ashuga. Chifukwa chake, mutanyamula mwana wosabadwayo, chithandizo chamankhwala choterocho chimayima.

Sizikudziwika ngati zosakaniza kapena zina zowonjezera zimadutsa mkaka wa m'mawere. Chifukwa chake, chiwopsezo cha zovuta mu makanda chifukwa chogwiritsa ntchito mankhwalawa sichingadziwike.

Ana aang'ono sayenera kumwa mankhwalawa.

Ngati zovuta zazing'onoting'ono ndi ntchito ya impso zikuchitika, mlingo wake suyenera kusintha. Mankhwalawa amadziwikiridwa kwa anthu omwe ali ndi hepatic ndi aimpso kulephera kwapakati komanso kovuta.

Ngati chiwindi sichikuyenda bwino, mlingo wake sukusinthidwa, kusokonezeka kwakukulu kwa chiwalochi kumafuna kusamala mukamagwiritsa ntchito, mulingo wochepa wa 5 mg umayikidwa, ngati munthu angalekerere mankhwalawo mwachizolowezi, kuchuluka kwake kumachulukitsidwa mpaka 10 mg.

Kuchita ndi mankhwala ena

Mankhwala timapitiriza mphamvu ya thiazide okodzetsa, kumawonjezera mwayi wamthupi ndi hypotension. Pogwiritsa ntchito insulin ndi mankhwala omwe amalimbikitsa kutulutsidwa kwa timadzi timeneti, hypoglycemia imayamba.

Chifukwa chake, kuchepetsa mwayi wokhala ndi vutoli ndi kuphatikiza kwa mankhwala Forsig omwe ali ndi insulin kapena njira zina, mlingo umasinthidwa.

Kagayidwe kake ka mankhwala nthawi zambiri kumakhala mawonekedwe a glucuronide conjugation ndi ntchito ya chigawo UGT1A9.

Metformin, Pioglitazone, Glimepiride, Bumetanide sizikhudza katundu wa mankhwala a Forsig. Pambuyo ophatikizidwa ndi rifampicin, wothandizila wa causative wa maulendo osiyanasiyana okhathamiritsa ndi zida za endocrine, mankhwalawa amaphatikizidwa, ndipo kuwonekera kwadongosolo kumatsika ndi 22%.

Izi ndizowona ngati palibe zovuta pakuchotsa shuga m'mitsempha. Kugwiritsira ntchito inducers kwina sikukhudza mankhwalawa. Pambuyo pophatikizana ndi mefenamic acid, 55% ya chiwonetsero cha dapagliflozin chimachotsedwa m'thupi popanda vuto lalikulu pakuwona kwa shuga mumkodzo. Chifukwa chake, mlingo wa mankhwalawa sasintha.

Makampani amakono azamalonda amapereka mitundu iwiri ya mankhwala a Forsig:

Mankhwalawa ali ndi zonunkhira zomwezi. Mtengo wa analogues ukhoza kufikira ma ruble 5000. Forsiga ndiye chida chotsika mtengo kwambiri chotchulidwa.

Malangizo

Mankhwala Forsig adalembedwa kuti adokotala amupatse. Amatulutsidwa m'mafakitoreti kokha ndi mankhwala.

Kuletsa kuyendetsa galimoto mutamwa mankhwalawa - ayi. Koma izi ndichifukwa choti maphunziro ngati amenewa sanachitike. Palibenso chidziwitso chokhudzana ndi mankhwalawa ndi mowa ndi chikonga.

Kusintha kwina kulikonse mukamamwa mankhwalawa kuyenera kuuzidwa kwa dokotala yemwe akuthandizani.

Mankhwala a m'badwo watsopano wa Forsig posachedwapa adapezeka pamashelefu osokoneza bongo. Ngakhale ndizokwera mtengo, ndizotchuka.

Forsiga bwino amakhala ndi matenda a shuga m'magazi ndipo nthawi yayitali amasunga zotsatira.

Mankhwalawa alibe vuto lililonse. Milandu ya mankhwala osokoneza bongo kapena poizoni sichinadziwikebe. Koma ngakhale zili choncho, simungathe kudzilankhulira nokha.

Kutalika kwa maphunziridwe ake ndi kumwa kwa mankhwalawa kumatsimikiziridwa ndi dokotala yemwe amadziwa chifaniziro chachikulu cha matenda. Ngati muphwanya malangizowo, pamakhala chiopsezo chokhala ndi zotsatira zoyipa komanso mankhwala osokoneza bongo.

Ndemanga za Endocrinologists

Madokotala nthawi zambiri samatha kudziwa momwe mankhwalawo angachitire. Kuti muwone mndandanda wathunthu wa contraindication ndi zovuta, ndikofunikira kuti mukhale zaka zingapo. Zosintha paumoyo wamunthu chifukwa chakumwa zimatha kupitilira nthawi.

Mtengo wa mankhwalawa sukulola kugwiritsidwa ntchito kwake kwakukulu, mankhwalawo ndi oyenera pongoyimitsa Zizindikiro, samachiritsa zovuta zazikulu mthupi, mankhwalawo sanaphunzire kwathunthu. Odwala nthawi zambiri amakumana ndi vuto la mkodzo.

Ndemanga Zahudwala

Mwezi woyamba kugwiritsa ntchito, kachilomboka kamaonekera, adotolo adapereka maantibayotiki. Pambuyo pa masabata awiri, thrush idayamba, pambuyo pake palibe mavuto, koma mlingo unayenera kuchepetsedwa. M'mawa, kunjenjemera kumachitika chifukwa cha shuga m'magazi. Sindikucheperachepera, ndinayamba kumwa mankhwala miyezi 3 yapitayo. Ndikupanga zotsatira zoyipa, ndikufuna kupitiliza chithandizo.

Amayi ali ndi mtundu wovuta wa matenda ashuga, tsopano amagwiritsa ntchito insulin tsiku ndi tsiku, amapita kwa dokotala wa macho pafupipafupi, akuchitidwa opaleshoni ya 2, mawonekedwe ake akupitilirabe. Pali mantha kuti nditha kudutsa izi.

Pausinkhu wanga ndimakhala wofooka kale, nthawi zina ndimamva chizungulire, khungu limawonekera. Kusanthula kunawonetsa kuchuluka kwa shuga mpaka 15 mmol / L. Dotolo adakhazikitsa Forsig ndi zakudya, tsopano ndimapita kukamuwona.

Matenda a shuga nthawi zonse amayambitsa zovuta zakupha. Mwazi wamagazi ochulukirapo ndi woopsa kwambiri.

Lyudmila Antonova mu Disembala 2018 adafotokoza mwatsatanetsatane za chithandizo cha matenda ashuga. Werengani kwathunthu