Hypoglycemic mankhwala Starlix

Starlix ndi mankhwala a hypoglycemic ochokera ku phenylalanine amino acid. Mankhwalawa amathandizira kuti pakhale insulin mphindi 15 munthu atatha kudya, pomwe kusinthasintha kwa shuga m'magazi kumatha.

Chifukwa cha ntchito iyi, Starlix simalola kukula kwa hypoglycemia ngati, mwachitsanzo, munthu wasowa chakudya. Mankhwala amagulitsidwa monga mapiritsi okhala ndi filimu; aliyense wa iwo ali ndi 60 kapena 120 mg ya yogwira mankhwala nateglinide.

Zina zomwe zimaphatikizidwa ndi magnesium stearate, titanium dioksidi, lactose monohydrate, macrogol, iron ironide, croscarmellose sodium, talc, povidone, cellcrystalline cellulose, colloidal anhydrous silicon dioxide, hypromellose. Mutha kugula mankhwala ku malo ogulitsira kapena apadera, mumapaketi a 1, 2 kapena 7 matuza, chithuza chimodzi chimakhala ndi mapiritsi 12.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

· Anhydrous silicon dioxide (colloidal),

· Titanium dioxide E171,

Hypromellose.60Pa mtolo wa makatoni pakhoza kukhala 1, 2, 5, 7, 10, 30 matuza a mapiritsi 12 lililonse. Mapiritsi Oval mu chipolopolo chachikaso, cholembedwa STARLIX kutsogolo. Kumbuyo - mlingo wa mankhwala "120".120 Mapiritsi okhala ndi STARLIX olembedwa - mbali imodzi ndikulemba "180" - mbali inayo. Mapiritsi ofiira ali ndi zokutira zamafilimu, mawonekedwe a oval ndi mtundu wofiira.180

Zotsatira za pharmacological

Nateglinide ndi lotuluka mu phenylalanine. Thupi limabwezeretsa kupanga kwa insulin koyamba. Kuwonjezeka kwa ndende ya mahomoni kumachepetsa shuga ndi glycosylated hemoglobin A1C.

Kuchulukitsa kwa mahomoni kumagwira ntchito kwa mphindi 15 mutatha kudya. Maola 3,5 otsatira, kuchuluka kwa insulin kumabwereranso pamitundu yake yoyambirira, kupewa hyperinsulinemia.

ZOFUNIKIRA Katulutsidwe wa insulin kudzatengera mwachindunji kuchuluka kwa shuga m'magazi.

Kuthekera kwa mankhwalawa, ngakhale pamlingo wochepetsedwa, kuwongolera kuchuluka kwa mahomoni kumakupatsani mwayi wopewa kupezeka kwa hypoglycemia ndi kutsika kwa thupi, wodwala akukana kudya.

Kufotokozera za mankhwalawa

Mankhwala ali ndi ndemanga zabwino. Zimathandizira kubwezeretsa katulutsidwe koyambirira ka insulin, komanso kuchepa kwa kuchuluka kwa shuga ndi magazi a glycated hemoglobin.

Njira yotereyi ndiyofunikira kwa anthu odwala matenda ashuga, chifukwa omwe shuga mumagulu amomwe amapezeka. Mu shuga mellitus, gawo ili la insulin katulutsidwe limasokonekera, pomwe nateglinide, yomwe ndi gawo la mankhwalawa, imathandizira kubwezeretsa gawo loyambirira la kupanga mahomoni.

Mosiyana ndi mankhwalawa, Starlix amayamba kupanga insulin mkati mwa mphindi 15 mutatha kudya, zomwe zimapangitsa kuti odwala matenda ashuga azisintha komanso azichulukitsa kuchuluka kwa shuga m'magazi.

1. Kwa maola anayi otsatira, kuchuluka kwa insulini kubwerera ku mtengo wawo woyambirira, izi zimathandiza kupewa kupezeka kwa matenda a postprandial hyperinsulinemia, omwe mtsogolomo adzayambitsa chitukuko cha matenda a hypoglycemic.
2. Pamene ndende ya shuga imachepa, kupanga insulin kumachepa. Mankhwala, nawonso, amawongolera njirayi, ndipo pogwiritsa ntchito mitundu yochepa ya shuga, imakhala yofooka pakubisika kwa mahomoni. Ichi ndichinthu chinanso chabwino chomwe sichimalola kukula kwa hypoglycemia.
3. Ngati Starlix amagwiritsidwa ntchito musanadye, mapiritsi amatengedwa mwachangu m'mimba. Kuchuluka kwa mankhwalawa kumachitika mkati mwa ola lotsatira.

Mtengo wa mankhwalawa umatengera malo omwe amapangidwira, motero ku Moscow ndi Foros mtengo wa phukusi limodzi la 60 mg ndi ma ruble 2300, phukusi lolemera 120 mg lidzagula ruble 3000-4000.

Starlix mankhwala: malangizo ntchito

Ngakhale kuti mankhwalawa ali ndi ndemanga zabwino, ndikofunikira kufunsa dokotala musanagwiritse ntchito mankhwalawa.

Mapiritsi ayenera kumwedwa mphindi 30 asanadye. Kuti muthandizidwe mosalekeza ndi mankhwalawa nokha, mlingo wake ndi 120 mg katatu patsiku musanadye.

Pangakhale kuwoneka achire zotsatira, mlingo akhoza kuchuluka kwa 180 mg.

Panthawi yamankhwala, wodwalayo ayenera kuwongolera kuchuluka kwa shuga ndikusintha Mlingo wake potengera zomwe wapeza. Kuti muwone momwe mankhwalawo alili othandizira, kuyezetsa magazi kwa ma glucose kumachitika pambuyo pa ola limodzi kapena awiri mutatha kudya.

Nthawi zina wothandizira wina wa hypoglycemic amawonjezeredwa pamankhwala, omwe nthawi zambiri amakhala Metformin. Kuphatikiza Starlix imatha kukhala chida chowonjezera pothandizira Metformin. Pankhaniyi, ndi kuchepa komanso kuyandikira kwa HbA1c ofunikira, mlingo wa Starlix umachepetsedwa mpaka 60 mg katatu patsiku.

Ndikofunika kuganizira kuti mapiritsi ali ndi zotsutsana zina. Makamaka, simungathe kumwa mankhwalawa ndi:

• Hypersensitivity
• Insulin yodalira matenda a shuga
• Kuopsa kwa chiwindi,
• Ketoacidosis.
• Komanso, mankhwala contraindicated muubwana, pa mimba ndi mkaka wa m`mawere.

Mlingo suyenera kusintha ngati wodwala akutenga nthawi yomweyo Warfarin, Troglitazone, Diclofenac, Digoxin. Komanso, palibe kuyanika konse pakati pamankhwala ena a antiidiabetes omwe adawululidwa.

Mankhwala monga Captopril, Furosemide, Pravastatin, Nicardipine. Phenytoin, Warfarin, Propranolol, Metformin, Acetylsalicylic acid, Glibenclamide sizikhudza mayanjano a nateglinide ndi mapuloteni.

Ndikofunika kumvetsetsa kuti mankhwalawa amachulukitsa kagayidwe ka glucose, chifukwa chake, akamawamwa ndi mankhwala a hypoglycemic, kusintha kwa glucose kumasintha.

Makamaka, hypoglycemia mu shuga mellitus imalimbikitsidwa ndi ma salicylates, osasankha beta-blockers, NSAIDs ndi mao inhibitors. Mankhwala a Glucocorticoid, thiazide diuretics, sympathomimetics ndi mahomoni a chithokomiro amathandizira kuti kufooketsa kwa hypoglycemia.

1. Mtundu wachiwiri wa matenda ashuga, kusamalidwa kwapadera kuyenera kuchitidwa, popeza chiwopsezo cha kukhala ndi hypoglycemia ndichokwera kwambiri. Makamaka, ndikofunikira kuwunika kuchuluka kwa shuga m'magazi kwa anthu omwe amagwiritsa ntchito zida zopangira zovuta kapena magalimoto oyendetsa.
2. Odwala omwe ali pachiwopsezo chochepa, okalamba, odwala omwe ali ndi vuto la pituitary kapena adrenal insuffence amagwera m'dera langozi. Mwazi wamagazi umatha kuchepa ngati munthu amamwa mowa, amalimbitsa thupi kwambiri, komanso akamwa mankhwala ena a hypoglycemic.
3. Mankhwala, wodwalayo amatha kukumana ndi zovuta zotuluka thukuta, kunjenjemera, chizungulire, kuchuluka kwa chidwi, kuchuluka kwa mtima, nseru, kufooka, ndi kupepuka.
4. Kuchuluka kwa shuga m'magazi kumatha kutsika kuposa 3.3 mmol / lita. Nthawi zina, ntchito ya chiwindi michere mu magazi ukuwonjezeka, matupi awo sagwirizana, limodzi ndi zidzolo, kuyabwa ndi urticaria. Mutu, kutsegula m'mimba, kuuma, komanso kupweteka kwam'mimba ndizothekanso.

Sungani mankhwalawo pachipinda chofunda, kutali ndi dzuwa ndi ana. Moyo wa alumali ndi zaka zitatu, ngati nthawi yosungirako imatha, mankhwalawo amatayidwa ndipo sagwiritsidwa ntchito pazolinga zake.

Mitu ya mankhwalawa

Pazomwe zimagwiritsidwa ntchito, mawonekedwe ofananira a mankhwala kulibe. Komabe, lero ndizotheka kugula mankhwala omwe ali ndi zotsatira zofananira zomwe zimayendetsa shuga wamagazi ndipo osalola kuti hypoglycemia ipange.

Mapiritsi a Novonorm amatengedwa ngati amachokera mtundu wachiwiri wa matenda ashuga, ngati chithandizo chamankhwala, kuchepa thupi komanso kuchita masewera olimbitsa thupi sizithandiza kuti wodwalayo azidwala. Komabe, mankhwalawa amasemphana ndi mtundu wachiwiri wa matenda a shuga, matenda ashuga a ketoacidosis, matenda a shuga komanso chikomokere, komanso kulephera kwamphamvu kwa chiwindi. Mtengo wanyamula mapiritsi ndi ma ruble 130.

Mankhwala Diagnlinide amagwiritsidwa ntchito ngati mtundu wachiwiri wa matenda ashuga, kuphatikiza Metformin, ngati sizingatheke kusintha zizindikiro za shuga m'magazi m'njira zonse.

Mankhwalawa ali contraindicated mu mtundu 1 matenda a shuga, matenda ashuga ketoacidosis, matenda a shuga ndi chikomokere, matenda opatsirana, chithandizo cha opaleshoni ndi zina zofunika kwa insulin. Mtengo wa mankhwalawo umasiya ma ruble 250.

Mapiritsi a Glibomet amatengedwa a matenda a shuga a 2. Mlingo amasankhidwa payekha, kutengera kuchuluka kwa kagayidwe.

Mankhwalawa amatsutsana ndi matenda a diabetes ketoacidosis ndi mtundu 1 wa matenda a shuga, lactic acidosis, diabetesicoma ndi chikomokere, hypoglycemia, hypoglycemic chikomokere, chiwindi kapena impso, komanso matenda opatsirana. Mutha kugula chida chotere ma ruble 300.

Mankhwala Glucobai ndi othandiza pa matenda amtundu 1 komanso matenda a shuga. Mlingo wapamwamba wa tsiku lililonse ndi 600 mg patsiku. Mankhwalawa amatengedwa popanda kutafuna, ndimadzi ochepa, musanadye kapena ola limodzi mutatha kudya. Mtengo wa paketi imodzi yamapiritsi ndi ma ruble 350.

Mu kanema munkhaniyi, dokotala adzapereka malingaliro pazomwe angachepetse shuga ndimagazi ndikubwezeretsa katemera wa insulin.

Pharmacokinetics

Pambuyo pakukonzekera pakamwa, nateglinide imalowetsedwa m'matumbo ang'onoang'ono, mpaka imafikira ndende yambiri osakwana ola limodzi. Bioavailability wa 72%. Nthawi yofikira Cmax imayima payokha. Kumwa mankhwala ndi chakudya kumapangitsa kuti vutoli lisamavute. Bioavailability sasintha.

Nateglinide imamangiriza mapuloteni a plasma ndi 98%.

Changu chogwira ntchito chimasinthika m'chiwindi ndikugwira nawo ntchito kwa cytochrome P450 isoenzymes. Mukamaliza kuthana ndi kuphatikiza kwamagulu a hydroxyl, ma metabolites atatu ofunikira amapangidwa, omwe amatsitsidwa ndi impso. 7-16% ya mlingo woyambilira amakhalabe wosasinthika. Ndi ndowe, 10% ina ya chinthucho imachoka m'thupi. Hafu ya moyo wa Starlix ili pafupifupi ola limodzi ndi theka.

Type 2 shuga mellitus yotsika mtengo yolimbitsa thupi ndi zakudya.

Mankhwala

Katemera wa insulini yoyambirira poyankha kukoka kwa glucose ndikofunikira kwambiri pakukhazikitsa kuchuluka kwa shuga m'magazi. Mtundu wachiwiri wa matenda a shuga, kuphwanya / kusapezeka kwa gawo ili la insulin katemera kumawonedwa. Mothandizidwa ndi nateglinide yomwe idatengedwa musanadye, gawo loyambirira (kapena loyamba) la insulin katulutsidwe limabwezeretseka. Kapangidwe ka izi ndizowonjezera mwachangu komanso ndikusinthika kwa mankhwalawa ndi njira za K + -ATP zotengera ma β-cell a kapamba. Kusankhidwa kwa nateglinide pokhudzana ndi njira ya K + -ATP-yodalira pancreatic is-cell ndikutalika kochulukirapo kuposa pamenepo pokhudzana ndi mayendedwe a mtima ndi mitsempha yamagazi.

Nateglinide, mosiyana ndi othandizira ena am'magazi a hypoglycemic, amachititsa kubisalira kwa insulin m'mphindi 15 zoyambirira mutatha kudya, chifukwa chomwe kusinthasintha kwa m'mimba mwa m'magazi a "glucose" kumachitika. Maola atatu otsatira, kuchuluka kwa insulini kumabwereranso kuzikhalidwe zake zoyambirira, motero kupewa kupewa kwa postprandial hyperinsulinemia, komwe kungayambitse kuchepa kwa hypoglycemia.

Katulutsidwe wa insulin ndi ma β-cell a kapamba amachokera ku nateglinide kumadalira kuchuluka kwa kuchuluka kwa glucose m'magazi, ndiko kuti, pamene ndende ya glucose imachepa, insulin secretion imachepa. Momwemonso, kumiza nthawi yomweyo kapena kulowetsedwa kwa shuga kumapangitsa kuwonjezeka kwa insulin. Kutha Starlix pa kutsika kwa shuga m'magazi, kuperewera kwa insulini ndichinthu chowonjezera chomwe chikulepheretsa kukula kwa hypoglycemia, mwachitsanzo, pakadumphira chakudya.

Zogulitsa. Mukamamwa mapiritsi Starlix musanadye, nateglinide imatengeka mwachangu kuchokera mumimba. Nthawi yoti mufikire Cmax ndi yochepera ola 1. Bioavailability wa mankhwalawa ali pafupifupi 72%. Kwa zizindikiro monga AUC ndi Cmax, ma pharmacokinetics a nateglinide omwe ali ndi mlingo kuchokera pa 60 mg mpaka 240 mg amakhala pamzere wodwala omwe ali ndi matenda a shuga 2 katatu / tsiku sabata limodzi.

Kugawa. Kumangidwa kwa nateglinide kumapuloteni a seramu (makamaka ndi albumin, mpaka ochepera - okhala ndi acidic cy1-glycoprotein) ndi 97-99%. Kukula kwa mapuloteni samatengera kuchuluka kwa nateglinide mu plasma mu mndandanda womwe waphunziridwa wa 0.1-10 μg / ml. Vd ikafika pamlingo wofanana ndi 10 malita.

Kupenda. Nateglinide imapangidwa kwambiri mu chiwindi ndikupanga microsomal isoenzymes ya cytochrome P450 (70% isoenzyme CYP2C9, 30% CYP3A4). 3 zazikulu metabolites ya nateglinide chifukwa cha hydroxylation zimachitika mobwerezabwereza ma pharmacological zochita poyerekeza ndi poyambira.

Kuswana. Nateglinide imachotsedwa m'thupi mwachangu - maola 6 atayamba kumwa, pafupifupi 75% ya dokotalayo amamuchotsa mkodzo. Excretion imachitika makamaka ndi mkodzo (pafupifupi 83% ya mlingo), makamaka mawonekedwe a metabolites. Pafupifupi 10% amachotseredwa ndowe. Pazowerengeka zophunziridwa (mpaka 240 mg 3 nthawi / tsiku), kuwerengetsa sikunachitike. T1 / 2 ndi maola 1.5.

Mukamapereka nateglinide mukatha kudya, mayendedwe ake amachepetsa - Tmax imachulukitsa, Cmax imatsika, pomwe kukwaniritsidwa kwa mayeso (mtengo wa AUC) sikusintha. Pokhudzana ndi zomwe tafotokozazi, ndikulimbikitsidwa kutsatira Starlix chakudya chisanachitike.

Palibe kusiyana kwakukulu mwachipatala komwe kumapezeka mu pharmacokinetic magawo a nateglinide mwa odwala amuna ndi akazi.

Malangizo apadera. Zochita zamankhwala Starlix beta-blockers akuwonjezeka. Mukamwa Starlix, muyenera kupewa kumwa mowa, chifukwa izi zingayambitse kukulitsa zotsatira zoyipa.

Njira yogwiritsira ntchito

Starlix ayenera kumwedwa pamaso chakudya. Kutalika kwa nthawi pakati pa kumwa mankhwalawa ndi kudya sikuyenera kupitirira mphindi 30. Monga lamulo, mankhwalawa amatengedwa musanadye.

Mukamagwiritsa ntchito Starlix monga monotherapy, mlingo womwe umalimbikitsa ndi 120 mg katatu kapena tsiku (musanadye chakudya cham'mawa, chakudya chamadzulo ndi chakudya chamadzulo).

Metformin itha kutumizidwa kwa odwala omwe amalandira Starlix monotherapy ndipo akufunika mankhwala ena a hypoglycemic. M'malo mwake, odwala omwe alandila kale mankhwala a metformin amatha kupatsidwa mankhwala a Starlix pa 120 mg katatu / tsiku (musanadye chakudya) ngati chida chowonjezera. Ngati, motsutsana ndi maziko a chithandizo cha metformin, mtengo wa HbA1c ukafika pamtengo womwe umafunikira (osakwana 7.5%), mlingo wa Starlix ukhoza kukhala wochepa - 60 mg 3 nthawi / tsiku.

Panalibe kusiyana pakukhazikika ndi chitetezo cha Starlix mwa odwala okalamba komanso anthu ambiri. Kuphatikiza apo, zaka za odwala sizinakhudze ma paracokinetic magawo a Starlix. Chifukwa chake, kwa okalamba odwala, kusintha kwapadera kwa mankhwalawa sikofunikira.

Kuchita bwino ndi chitetezo cha Starlix mwa ana sichidaphunziridwe, kotero kusankhidwa kwake sikulimbikitsidwa kwa ana.

Odwala omwe ali ndi vuto lochepa kwambiri la hepatic, kusintha kwa mlingo sikofunikira. Iwo ali osavomerezeka kuti agwiritse ntchito mankhwalawa odwala omwe ali ndi vuto la chiwindi kwambiri, chifukwa deta yakuyesedwa pachipatala siyikupezeka.

Odwala ndi mkhutu aimpso ntchito zosiyanasiyana zovuta (kuphatikizapo iwo a hemodialysis), kusintha kwa mankhwala sikufunika.

Contraindication

lembani matenda ashuga

Kuchita ndi mankhwala ena

Kafukufuku wa in vitro awonetsa kuti nateglinide imapangidwa kwambiri ndi cytochrome P450 isoenzymes - CYP2C9 (70%) ndi CYP3A4 (30%).

Nateglinide sizikhudza malo a pharmacokinetic a warfarin (gawo lapansi la CYP3A4 ndi CYP2C9), diclofenac (gawo lapansi la CYP2C9), troglitazone (inducer ya CYP3A4) ndi digoxin. Chifukwa chake, ndi nthawi imodzi Starlix ndi mankhwala monga warfarin, diclofenac, troglitazone ndi digoxin safuna kusintha kwa mlingo. Panalibe zofunika zamankhwala Starlix ndimankhwala ena amkati a antiidiabetesic monga metformin ndi glibenclamide.

Popeza nateglinide imakhala ndi mapuloteni ambiri a plasma, kuyesa kwa vitro kunayesa kuyanjana kwake ndi mankhwala omwe amamangidwa ndi mapuloteni ambiri, monga furosemide, propranolol, Captopril, nicardipine, pravastatin, warfarin, phenytoin, acetylsalicylic acid, glibenclamide ndi metformin. Zinawonetsedwa kuti mankhwalawa samakhudza kulumikizana kwa nateglinide ndi mapuloteni a plasma. Momwemonso, nateglinide sichitha malo a propranolol, glibenclamide, nicardipine, warfarin, phenytoin, ndi acetylsalicylic acid kuchokera kumangiriza kwa mapuloteni.

Tiyenera kudziwa kuti mankhwalawa amakhudza kagayidwe kakang'ono ka glucose, chifukwa chake akaperekedwa pamodzi ndi mankhwala a hypoglycemic, kuphatikiza StarlixKusintha kwa kuchuluka kwa glucose ndikotheka ndikuyang'aniridwa kuchipatala ndikofunikira. Zotsatira za hypoglycemic zitha kupitilizidwa ndi makonzedwe apakati a NSAIDs, salicylates, MAO inhibitors, osasankha beta-blockers. M'malo mwake, mphamvu ya hypoglycemic imatha kufooka ndi nthawi imodzi ya thiazide diuretics, glucocorticoids, sympathomimetics, ndi kukonzekera kwa mahomoni a chithokomiro.

Bongo

Milandu yambiri Starlix sichinafotokozedwe.

Zizindikiro: kutengera chidziwitso cha mapangidwe a mankhwalawa, titha kuganiza kuti zotsatira zazikulu zamankhwala osokoneza bongo zidzakhala hypoglycemia ndi matenda amawonetsa zovuta.

Chithandizo: Njira zochizira hypoglycemia zimatsimikiziridwa ndi kuuma kwa zizindikirazo. Ndi kuzindikira kosungika komanso kusowa kwa mawonekedwe a mitsempha, kudya shuga / shuga kumatsimikiziridwa, komanso kusintha kwa mankhwala ndi / kapena zakudya. Mu kwambiri hypoglycemia, limodzi ndi mawonekedwe a minyewa (chikomokere, kukomoka), yankho la glucose limasonyezedwa. Kugwiritsa ntchito hemodialysis kuchotsa nateglinide m'magazi sikothandiza chifukwa chogwirizana kwambiri ndi mapuloteni a plasma.

Malo osungira

Mankhwalawa amayenera kusungidwa pa kutentha osapitirira 30 ° C poikika yake yoyambirira, kuchokera kwa ana.

Piritsi limodzi lachifundo 1

• ntchito yogwira: nateglinide 60 ndi 120 mg,
• zotuluka: lactose monohydrate, microcrystalline cellulose, povidone, croscarmellose sodium, magnesium stearate, hypromellose, titanium dioxide (E171), talc, macrogol, anhydrous colloidal silicon dioxide, red iron oxide (E172).

Zosankha

Pogwiritsa ntchito Starlix pochiza odwala omwe ali ndi mtundu wa 2 matenda a mellitus (osagwirizana ndi insulin), kusamala pokhudzana ndi kupezeka kwa hypoglycemia kuyenera kuonedwa. Chiwopsezo cha kukhala ndi hypoglycemia mutamwa Starlix (komanso mankhwala ena a hypoglycemic) ndiwokwera kwambiri kwa okalamba omwe ali ndi kuchepa kwa thupi pamaso pa adrenal kapena pituitary insuffence. Kutsika kwa glucose m'magazi kungayambike chifukwa chomwa mowa, kuchuluka kwa zochita zolimbitsa thupi, komanso kugwiritsa ntchito munthawi yomweyo mankhwala ena a hypoglycemic.

Kugwiritsa ntchito nthawi yomweyo kwa beta-blockers kungatchinjirize kuwonetsa kwa hypoglycemia.

Kukopa pa kuyendetsa magalimoto ndi kayendedwe kazinthu

Odwala omwe amagwira ntchito ndi makina ndi magalimoto oyendetsa ayenera kusamala kuti apewe hypoglycemia.

Zotsatira zoyipa

Kulandila kungayambitse kuwonetsa zotsatirazi zosafunika:

• Kuchepetsa msana ndi kufooka
• Kuchepetsa chidwi
• Kutopa ndi chizungulire,
• Kuchulukitsa thukuta
• Kutunda kwa miyendo.

Zizindikiro zimawonekera mwa odwala omwe ali ndi kuchuluka kwa glucose osakwana 3.4 mmol / L. Kudutsa ndi shuga.

Zosowa zina zimakhala zotupa ndi redness khungu, nthawi zina kuwonjezeka kwa ntchito ya chiwindi michere.

Kuyanjana kwa mankhwala osokoneza bongo

Starlix imachepetsa mphamvu ya tolbutamide.

Nateglinide sichilumikizana ndi magawo a cytochrome:

• for CYP2C9 - diclofenac,
• kwa CYPЗА4 ndi CYP2С9 - warfarin.

Komanso osadziwika ndi digoxin, troglitazone.

Chogwiritsidwachi sichikhudza zochita za metformin ndi glibenclamide. Beta-blockers amatha kufinya zizindikiro za hypoglycemia.

Ndikotheka kukwaniritsa kuwonjezeka kwa zotsatira za nateglinide ndikumamwa ma monooxidase inhibitors (MAOs), mankhwala osapweteka a antiidal komanso mankhwala a salicylates. Glucocorticosteroids, mahomoni a chithokomiro, sympathomimetics, thiazide diuretics amachepetsa mphamvu. Nthawi yomweyo, kugwirizira kwa glucose kuyenera kuyendetsedwa mwamphamvu.

Palibe kukonza kwina kwa chizolowezi chatsiku ndi tsiku komwe kumagwiritsidwa ntchito nthawi yomweyo ndimankhwala omwe amamangirira mapuloteni a plasma (acetylsalicylic acid, Captopril, nicardipine, propranolol, furosemide).

Kugwiritsa ntchito pamodzi kwa Starlix ndimankhwala ena a hypoglycemic action kungayambitse kutsika kwa glucose.

Malangizo apadera

Kumwa mowa ndi kuchita zinthu zambiri zolimbitsa thupi kumatha kudzetsa hypoglycemia.

Pambuyo maola awiri mutatha kudya, ndikofunikira kuti mupange kuyesa kwa shuga.

Zofunika! Mankhwala amakhudza kasamalidwe kagalimoto, chifukwa chake madalaivala ndi anthu omwe ntchito zawo zimagwirizanitsidwa ndi kasamalidwe ka machitidwe, ayenera kusamala.

Itha kugwiritsidwa ntchito limodzi ndi mankhwala ena a hypoglycemic - mwachitsanzo, metformin. Komanso, adotolo amayenera kupereka Starlix ngati monotherapy.

Fananizani ndi fanizo

“Posachedwa, ndidayamba kumwa madzi ambiri, ludzu lidangopezeka, popanda chifukwa ndidayamba kuyamwa, kupanikizika. Ndidawerenga za zizindikirazo, ndidazindikira kuti ndili ndi matenda ashuga. Ndinapita kwa dotolo, kuti matendawo adatsimikizira Iwo adalemba Starlix. Mankhwala sanali otsika mtengo. Ndidasankha kuchita monga adokotala adanenera. Asanamwe mankhwalawa, shuga anga anali ndi zaka 12, tsopano - 7. Kupanikizika kunachepa pang'ono, kuyimitsa kuyabwa, kunalibe ludzu. M'mawu ena, zinthu zayamba bwino. Koma chinthu chofunikira kwambiri ndicho kutsatira zakudya. ”

Kostya 2016-09-15 14:11:37.

Mapiritsi a Starlix ndi mankhwala amphamvu. Ndiyenera kumwa ndi shuga pamtunda wa 10. Kutsikira mpaka ku 3 ".

Antonina Egorovna 2017-12-11 20:00:08.

"Adalemba a Maninil chaka chatha. Kunalibe shuga wabwino. Ndidapita kwa dotolo wina, adatulutsa Starlix. Ndinayenera kumwa mapiritsi awiri a 60 mg pamodzi ndi Glucofage m'mawa komanso asanagone. Ndikumva bwino. Shuga pomaliza abwerera.

Momwe mungagwiritsire ntchito: Mlingo ndi njira ya chithandizo

Mkati, nthawi yomweyo musanadye chakudya (nthawi yomwe pakati pa kumwa mankhwalawa ndi kudya sayenera kupitirira mphindi 30).

Ndi monotherapy, mlingo womwe umalimbikitsa ndi 120 mg katatu pa tsiku (musanadye kadzutsa, nkhomaliro ndi chakudya chamadzulo). Ngati sizotheka kukwaniritsa zomwe mukufuna, muyeso umodzi umakulitsidwa mpaka 180 mg.

Rimage regimen imasinthidwa malinga ndi zomwe zimatsimikiziridwa nthawi zonse glycosylated Hb. Popeza chithandizo chachikulu ndikuchepetsa kuchuluka kwa shuga m'magazi, kuchuluka kwa shuga wamagazi kwa maola 1-2 mutatha kudya kungagwiritsidwenso ntchito kuwunika momwe mankhwalawa amathandizira.

Kuphatikiza kwa mankhwalawa, nateglinide imayikidwa pa mlingo wa 120 mg katatu patsiku limodzi ndi metformin, ngati phindu la glycosylated Hb likufika pa mtengo womwe umafunikira (osakwana 7.5%), mlingo umatha kuchepetsedwa mpaka 60 mg katatu patsiku.

Pankhani ya kuwonongeka kwa impso, kusintha kwa mankhwalawa sikofunikira.