Diabetes, metformin kapena manninil: ndibwino?

Maninil ndi mankhwala ochizira matenda amtundu wa 2. Chofunikira chachikulu pa icho ndi glibenclamide. Maninil nthawi zambiri amalembera anthu odwala matenda ashuga.

Komanso, odwala ali ndi mafunso ambiri omwe tidzayankha m'nkhaniyi. Mwachitsanzo:

Mlingo uti womwe umagwira kwambiri - 1.75, 3.5 kapena 5 mg patsiku.

Mankhwala otani omwe amaposa Maninil.

Zoyenera kuchita ngati chithandizo sichikuthandizani.

Ndi mankhwala ati omwe ndi abwino: Maninil, Glucofage, Diabetes kapena Metformin osati kokha.

Malangizo ogwiritsira ntchito

Mankhwala amathandizira kupanga insulin ndi masamba a beta a kapamba, amathandizira kuti azilowa mosavuta m'maselo a thupi, amachepetsa kuchuluka kwa shuga m'magazi kuchokera m'chiwindi. Nthawi yomweyo, kuchuluka kwa maplatifomu kumachepa, zomwe zimalepheretsa mapangidwe azigazi.
Mankhwalawa amatengedwa mwachangu kuchokera kugaya chakudya, choncho amatha kumwedwa musanadye. Hafu ya mankhwalawa imachotsedwa impso, ndipo theka lachiwiri ndi chiwindi. Maninil sadziunjikira m'thupi.

Chizindikiro cha mankhwalawa ndi mtundu wachiwiri wa matenda a shuga, omwe sangathe kuwongoleredwa ndi zakudya komanso zolimbitsa thupi.

• Mtundu woyamba wa shuga.
• Type 2 shuga mellitus mu gawo la kuwonongeka ndi ketoacidosis kapena chikomokere.
• Matenda a chiwindi ndi impso zoopsa.
• Mowa
• Pachimake matenda a matenda achilengedwe.
• Nthawi yochira pambuyo pochita opaleshoni, kutentha kwambiri ndi kuvulala kwina.
• Zakudya zopatsa mphamvu zochepa, zovuta m'mimba.
• Kusagwirizana ndi glibenclamide ndi zotumphukira za sulfonylurea.

Ngati munthu wayamba kudwala chifukwa cha thanzi, ndiye kuti muyenera kukana kumwa Maninil.
Pa mankhwala, tikulimbikitsidwa kupewa ntchito ndi zochitika zina zokhudzana ndi kuchuluka kwa chidwi.

Maninil amatengedwa m'mawa ndi madzulo asanadye. Mankhwala aledzera kwathunthu, osafuna. Mlingo amasankhidwa ndi dokotala. Njira yotulutsira mankhwala: mapiritsi a 1.75, 3.5 ndi 5 mg.
Yambani chithandizo ndi kutenga theka la piritsi. Wapakati mlingo ndi piritsi limodzi 2 pa tsiku. Nthawi zina, koma kawirikawiri, odwala amapatsidwa mapiritsi 2 kawiri pa tsiku.

Zochitika zovuta zimachitika nthawi zambiri ndikusankha kwa yolakwika ya mlingo. Chifukwa chake, kutenga Maninil kumatha kuchepetsa shuga m'magazi ndikuwongolera kukula kwa hypoglycemia. Ichi ndi chowopsa chomwe chimapha.
Zotsatira zina zoyipa zimaphatikizidwa ndi mseru, kusanza, kutentha thupi, kuchepa kwa masoka, kuona kwa dzuwa.

Nthawi ya bere ndi kuyamwa

Kuvomereza kwa mankhwala sikololedwa. Majekiseni a insulin okha omwe angagwiritsidwe ntchito pakadali pano.

Kuchita ndi mankhwala ena

Musanatenge Maninil ndi mankhwala ena, muyenera kufunsa katswiri. Maninil amatha kuthana ndi ma steroid, ACE zoletsa, beta-blockers, coumarins, pentoxifylline, phenibutazole, reserpine, etc.

Mukamamwa mankhwala ochulukirapo, kuseka thukuta, kunjenjemera kwa malekezero, kuwonda kwambiri, kupweteka kwa mutu, ndi chilakolako chambiri. Munthu akhoza kuyamba kugona. Ngati bongo ndi wofunikira, ndiye kuti zotsatira zake zingathe. Chifukwa chake, matendawa amafunika chisamaliro chachipatala.

Kutulutsa mawonekedwe, mawonekedwe osungira ndi mawonekedwe

Fomu yotulutsira: mapiritsi a 1.75, 3.5 ndi 5 mg. Mtundu wa mapiritsiwo umasiyanasiyana kuchokera ku pinki yotuwa kupita yapinki.
Chofunikira chachikulu: glibenclamide.
Omwe amathandizira: lactose monohydrate, wowuma, silicon dioxide, methyl hydroxyethyl cellulose, magnesium stearate, cochineal red.
Mankhwala safuna malo osungirako apadera.
Moyo wa alumali ndi zaka zitatu.

Imakhazikitsa kampani yaku Germany ya Berlin-Chemie AG / Menarini. Mtengo wake ndiwotsika mtengo kwa anthu ambiri. Analogue ya mankhwalawa ndi mankhwala a Glimstrad, omwe amapangidwanso ku Germany.

Ma analogu otsika mtengo amapangidwa ndi kampani ya Atoll, yomwe amalembetsa ku Russia. Ngakhale Maninil salinso mankhwala odula. Chifukwa chake, kusinthanitsa ndi analogu ndi kopanda tanthauzo.

Ndondomeko yolandirira

Pa nthawi ya makonzedwe, piritsi imayenera kumeza lonse, kapena kudula mbali ziwiri, koma osatafuna. Amamwa kawiri patsiku - m'mawa ndi madzulo. Mlingo amasankhidwa ndi endocrinologist. Kudzilamulira kwa Maninil ndikosavomerezeka, chifukwa Mlingo wosalondola ungayambitse kukulitsa mavuto. Mutatha kumwa mankhwalawa, muyenera kudya kuti magazi a shuga asatsikire kumagazi ovuta.

Maninil muyezo womwe dokotala watchulidwa ndi dokotala watha kukhala ndi zotsatira zomwe akufuna, ndiye kuti sizingatheke. Ndikofunikira kukaonana ndi dokotala. Mokulira, kusinthana kwa jakisoni wa insulin kudzafunika.

Kodi pali bwino Maninil kapena Diabeteson?

Maninil ndi Diabeteson amakhazikika pazinthu zosiyanasiyana zogwira ntchito, koma ali m'gulu lomweli (zotumphukira za sulfonylurea). Amachepetsa shuga m'magazi, koma posankha molakwika, hypoglycemia imayamba.

Diabetes imatenga nthawi yayitali kuposa Maninil. Chifukwa chake, ndikokwanira kuitenga kamodzi patsiku.

Mawonekedwe a Diabetes

Choyamba, ndikufuna kukhala pa Diabeteson, yomwe imagwiritsidwa ntchito pa matenda a shuga a 2. Chida ichi ndi chabwino chifukwa chimathandizira kupanga insulini, komanso imathandizira kuchuluka kwa zimakhala. Kuphatikiza apo, mankhwala omwe aperekedwa amakupatsani mwayi wochepetsera nthawi yakudya chakudya kuti mupange insulin. Palibe mawonekedwe ofunika kwambiri omwe akuyenera kuwonedwa ngati kuchepa kwa cholesterol.

Ndizodziwikanso kuti pamaso pa nephropathy, mankhwalawa amathandizira kuchepetsa kuchuluka kwa proteinuria. M'milandu yambiri, chisankho chomaliza chogwiritsira ntchito ndalamazo chimatengedwa ndi akatswiri pokhapokha kuwunika konse kukamalizidwa. Mwambiri, odwala matenda ashuga amayesedwa ngati chida chomwe chimathandizira thupi. Komabe, alinso ndi zotsutsana zingapo zomwe zimayenera kuyang'aniridwa kuchokera kwa odwala matenda ashuga.

Ponena za malire, ndikofunikira kulabadira kupezeka kwa mtundu wa 1 shuga mellitus, chikomokere kapena precomatose state. Kuphatikiza apo, kuphwanya lamulo ndikuphwanya impso ndi chiwindi, komanso kuchuluka kwa chidwi cha zigawo zina monga sulfonamides ndi sulfonylurea. Ndi momwe aperekera matendawo, zovuta zonse zolimbitsa thupi zimayikidwa, komanso kutsatira zakudya zina.

Poona kuti izi sizipangitsa kuti azitha kuthana ndi matendawa, perekani mankhwala omwe amatchedwa Diabeteson.

Gliclazide, yomwe imaphatikizidwa mndandanda wake wazinthu, imalola ma cell a kancensa kuti apange insulin yambiri. Zotsatira zakugwiritsa ntchito gawo limayesedwa kwambiri ngati zili zabwino. Polankhula pazinthu zina, ndikofunikira kulabadira kuti:

1. Odwala amatengera kuchepa kwakukulu kwa zizindikiro zamagulu a shuga, pomwe mwayi wa hypoglycemia ndi wochepera 7%,
2. Ndiosavuta kugwiritsa ntchito mankhwala amenewa kamodzi patsiku, ndipo chifukwa chake odwala sakonda kusiya chithandizo chotere cha matendawa,
3. Zizindikiro zakulemera zimachulukanso, koma pang'ono, zomwe nthawi zambiri sizikhudza thanzi lawo.

Akatswiri amalimbikitsa kugwiritsa ntchito Diabeteson, chifukwa ndi yabwino kwambiri kwa odwala ndipo imalekerera popanda mavuto. Ambiri mwa odwala matenda ashuga sawona kukhala kosavuta kugwiritsa ntchito piritsi limodzi pakapita maola 24 aliwonse kuposa kungokhala ndi zochitika zolimbitsa thupi komanso kudya kwambiri. Akatswiri amadziwa kuti ndi 1% yokha ya odwala omwe adakumana ndi zodandaula zilizonse zomwe zimachitika, pomwe odwala omwe adatsala amawona bwino komanso samakumana ndi mavuto azaumoyo.

Contraindication adaziwona kale, koma tsopano ndikofunikira kuzindikira zolakwitsa zina za mankhwala. Choyamba, tikulankhula za momwe zimachitika pakufa kwa maselo a beta, omwe amaphatikizidwa ndi kapamba. Potere, mawonekedwe a pathological amatha kusintha kukhala mtundu woyamba wovuta. Gulu lamavuto limaperekedwa makamaka kwa anthu omwe ali ndi thupi loonda. Kusintha kwa gawo lovuta kwambiri la matendawa, nthawi zambiri, kumatenga zaka ziwiri mpaka zisanu ndi zitatu.

Mankhwalawa amachepetsa shuga, koma samachepetsa kufa. Ndikofunikira kutengera chidwi kuti akatswiri amapereka mankhwala a shuga, koma izi sizolondola. Kafukufuku wambiri akuwonetsa kuti ndikofunikira kuti ndiyambire ndi Metformin, yomwe idakhazikitsidwa pazomwe zimaphatikizidwa.

Mapangidwe monga Siofor, Glformin ndi Glyukofazh ali m'gulu lomweli.

Mawonekedwe a Manin

Maninil mapiritsi a shuga mellitus amatchulidwa kuti muchepetse magazi pamavuto amtundu wachiwiri wa matenda. Mankhwala amadziwika ndi pancreatic algorithm yowonekera, komanso amakupatsani mwayi wolimbikitsa maselo a beta okhudzana ndi kapamba. Kuphatikiza apo, ndiye gawo lomwe limaperekedwa lomwe limakulitsa chiwopsezo cha insulin receptors, chomwe ndichofunikira kwambiri mu matendawa komanso mthupi lonse.

Poyerekeza Maninil ndi Diabetes, ndikufuna ndikuwuzeni kuti mtundu 1 wa shuga ndiwopondanso kugwiritsa ntchito pamenepa. Kuphatikiza apo, akatswiri amapereka chidwi pakuwonjezereka kwa zinthu zina zapagulu. Tisaiwale za kuchotsedwa kwa kapamba, matenda a impso, komanso matenda a chiwindi. Kusagwirizana kofunikira kwambiri kuyenera kuganiziridwa nthawi yoyamba pambuyo pa opaleshoni yokhudzana ndi chiwalo chilichonse chamkati. Simalimbikitsidwa kugwiritsa ntchito mapangidwe anthawi zonse pamene muli ndi pakati, komanso mukamayamwitsa komanso m'matumbo.

Akatswiri akuwunika chidwi chakuti chipangidwe chamankhwala cha odwala matenda ashuga Maninil chimadziwika ndi zotsatira zoyipa zingapo. Polankhula za izi, akatswiri amalabadira kuthekera kwa hypoglycemia. Kuphatikiza apo, ndikulimbikitsidwa kuti muzisamaliranso mseru ndi kusanza, kuwonjezera kwa jaundice, hepatitis, zotupa pakhungu. Zotsatira zoyipa zingaphatikizepo kupweteka kwapakati komanso kuwonjezeka kwa kutentha kwa thupi.

Popeza zonsezi, ngati lingaliro lipangidwe kuti lisinthe mankhwala ena ndi mawonekedwe ake, ndikulimbikitsidwa kuti mukafunse katswiri. Adzakhala amene apanga pulogalamu inayake ya algorithm ndi mlingo wake.

Kuphatikiza apo, akatswiri akuwunikira kuti sulfonylureas amadziwika ndi vuto lalikulu poyerekeza ndi maubwino owonetsa thupi omwe ali ndi matenda omwe aperekedwa. Kusiyanitsa komwe kumatsimikiziridwa pakati pa Maninil ndi Diabeteson ndikuti gawo loyamba lazinthu zamankhwala limaganiziridwa ndikuzindikiridwa kwambiri.

Kuopsa kwa vuto la mtima, komanso matenda amtima kumaonjezereka kapena kuwonjezereka mukamagwiritsa ntchito mankhwalawa.

Kupereka chidziwitso chowonjezera pakuyerekeza kwa mankhwala aliwonse omwe aperekedwa, ndikofunikira kulabadira njira yomwe amasankha. Malinga ndi akatswiri, a shuga ndiwotsika mtengo masiku ano. Kuphatikiza apo, nthawi zambiri imasankhidwa chifukwa chothandiza kwambiri m'thupi la munthu. Mutha kugula ku malo ogulitsira, koma ndikulimbikitsidwa kuti mugwiritse ntchito ndendende kuchuluka komwe anakumana ndi katswiri wa matenda ashuga.

Mawonekedwe a Metformin

Ndikufuna kuti tisonyezenso mankhwala ena omwe amagwiritsidwa ntchito ngati mtundu 2 wa shuga - Metformin. Zotsatira za gawo loperekedwalo zimasiyana ndi mankhwala ena chifukwa mwakuti mwatsatanetsatane antihyperglycemic amadziwika. Izi zimadziwika chifukwa ma algorithm omwe amachepetsa shuga m'magazi samayenderana ndi kuchuluka kwa insulin.Makina ochitapo kanthu pankhaniyi akuwoneka motere:

• pali kuponderezana kwamatenda a shuga m'chiwindi,
• kuchuluka kwa chiwopsezo cha gawo la mahomoni kumawonjezeka,
• kukhathamiritsa shuga mayamwidwe algorithm mwachindunji mu minofu ndi chiwindi.

Zitachitika izi, njira ya mayamwidwe a shuga m'matumbo amachepetsa. Zotsatira zabwino za Metformin ziyenera kuthandizidwa kuwongolera kuchuluka kwa glycemia ndikuchepetsa mwayi wamagazi. Poterepa, mwayi wokhala ndi mtima wazomwe zimachitika.

Ndikofunikira kumvetsetsa kuti gawo lomwe limaperekedwa ndi mankhwala limaperekedwa kwa odwala omwe ali ndi kunenepa kwambiri kwa thupi komanso kupezeka kwa kunenepa kwambiri. Zotsatira zoyipa zogwiritsa ntchito piritsi ndi kutsekula m'mimba, komanso mawonetsedwe ena a dyspeptic. Nthawi yomweyo, zovuta zomwe zikuperekedwa zimasowa zokha patatha masiku angapo.

Pofuna kupatula mphamvu ya zoyipa, ndikulimbikitsidwa kuti ndiyambe kuyambiranso ndi piritsi.

Gwiritsani ntchito mankhwalawa mutatha kudya kapena musanagone, mumamwa madzi ambiri kapena tiyi. Mavuto a Metformin amatha kuwunikira patatha pafupifupi sabata kuyambira poyambira kugwiritsa ntchito nthawi zonse. Nthawi zambiri mankhwalawa amadya kamodzi patsiku, zomwe zimakhala bwino komanso zotheka kwambiri kwa odwala matenda ashuga.

Ndi mankhwala ati omwe ali bwino?

Chifukwa chake, ndi katswiri yemwe angadziwe chomwe chiri bwino kuposa Maninil kapena Diabeteson. Tisaiwale kuti chilichonse chomwe chatchulidwacho chili ndi zotsutsana komanso zoyipa. Kuphatikiza apo, tisaiwale kuti pamsika wamakono pali zofananira za nyimbo zomwe zaperekedwa.

Mwanjira iyi komanso malingaliro onse a katswiri, zidzatheka kupeza chithandizo chokwanira cha matenda ashuga popanda kuwonjezera zovuta komanso zovuta.

Mankhwala a Maninil

Gawo lalikulu la Maninyl ndi glibenclamide - 1- <4-2- (5-chloro-2-methoxybenzamido) ethylbenzene sulfonyl> -3-cycloxyxylurea. Pulogalamuyi yogwira ntchito imachokera ku sulfonylurea ndipo ili ndi katundu wa hypoglycemic.

Kuchita kwa mankhwalawa kumadalira mphamvu yakuchepetsa shuga pochulukitsa njira yopangira ndi kutulutsa insulin ndi maselo a beta a pancreatic minofu. Zotsatira za mankhwalawa zimatengera kuchuluka kwa glucose omwe ali m'malo a maselo a beta.

Chida chachipatala chimathandizira kuletsa njira ya glucagon kumasulidwa ndi maselo a pancreatic alpha.Kugwiritsa ntchito mankhwalawa kumawonjezera kukonzekera kwa insulin komwe kumakhala pamwamba pa maselo a maselo a ma cell a zotumphukira zotengera insulin.

Pambuyo pakukonzekera kwa pakamwa mankhwala kulowa mthupi la munthu wodwala, kamakhala kamakhudzidwa kwathunthu m'magazi. Kumwa mankhwalawa nthawi yomweyo ndi chakudya sikukukhudza mayamwidwe, munthu ayenera kukumbukira kuti kumwa mankhwalawo ndi chakudya kungayambitse kuchepa kwa gawo lomwe limagwira m'magazi a magazi.

Pulogalamu yogwira imamangirako plasma albin, yomwe kumalumikizana kumafika 98%.

Pazitali zabwino za mankhwalawa zimatheka patatha maola 1-2 mutakhazikitsa mankhwala m'thupi.

Mankhwala amakhathamiritsa pafupifupi kwathunthu mu chiwindi mu ziwiri zazikulu metabolites. Ma metabolites awa ndi:

Zinthu zonse za metabolic zimachotsedwa kwathunthu kuchokera mthupi mokwanira, onse ndi bile ndi mkodzo. Kuchoka kwa mankhwalawa kumachitika maola opitilira 45-72. Hafu ya moyo wa main yogwira imachokera ku 2 mpaka 5 maola.

Ngati wodwalayo ali ndi vuto lalikulu la kulephera kwa impso, pamakhala kuthekera kwakukulu kodziwika kwa mankhwala m'thupi la wodwalayo.

Mlingo komanso kuphatikiza kwa Maninil ndi mankhwala ena

Kukhazikitsidwa kwa Manilin ndi dokotala wopezekapo kuyenera kumayendera limodzi ndi kusintha kwa zakudya. Mlingo wa mankhwala ogwiritsidwa ntchito zimatengera kwathunthu zomwe zikuwonetsa kuchuluka kwa shuga mu plasma yamagazi omwe amapezeka pakufufuzira.

Kugwiritsa ntchito mankhwalawa kuyenera kuyamba ndi mitundu yochepa. Mlingo wocheperako wa Maninil ndi piritsi la ½-1 la Maninil 3.5. Mtundu uwu wa mankhwalawa uli ndi 3.5 mg yogwira pophika. Pa gawo loyambirira la mankhwalawa, mankhwalawa amayenera kumwedwa kamodzi patsiku.

Mlingo woyambirira womwe umagwiritsidwa ntchito ungakulitse pang'onopang'ono ngati pakufunika. Mlingo wovomerezeka wamankhwala ndi 15 mg / tsiku.

Kusamutsa wodwala kuti agwiritse ntchito Maninil kuchokera ku zida zina zamankhwala kuyenera kuchitika mosamala.

Maninil angagwiritsidwe ntchito panthawi ya monotherapy komanso ngati mankhwala othandizira. Pa mankhwala, Maninil angagwiritsidwe ntchito limodzi ndi Metformin. Ngati wodwala amaletsa Metformin, Maninil angagwiritsidwe ntchito pochiza ndi mankhwala a gulu la glitazone.

Ngati ndi kotheka, kuphatikiza kwa Maninil ndi mankhwala monga Guarem ndi Acarbose ndikuloledwa.

Mukamamwa mankhwalawa, mapiritsi sayenera kutafunidwa. Kumwa mankhwala kuyenera kutsagana ndi kumwa madzi ambiri. Nthawi yoyenera kumwa mankhwalawa ndi nthawi yoyamba chakudya cham'mawa.

Ngati mukusowa nthawi yoyendetsera, simuyenera kugwiritsa ntchito mankhwalawa.

Kutalika kwa mankhwala a mono-ndi zovuta kumadalira momwe wodwalayo alili komanso mtundu wa matendawo.

Munthawi yamankhwala, kuyang'anira pafupipafupi momwe boma limagwirira ntchito zimafunikira. Glucose wa plasma amayenera kuyang'aniridwa pafupipafupi.

Zizindikiro ndi contraindication ogwiritsa ntchito Maninil

Chizindikiro chogwiritsa ntchito mankhwalawa ndi kupezeka kwa mtundu wachiwiri wa shuga wodwala.

Kugwiritsa ntchito mankhwalawa kuli koyenera ngati kugwiritsa ntchito moyenera masewera olimbitsa thupi komanso kudya kwapadera sikungayambitse zotsatira zabwino pochiza matenda a shuga 2.

Monga mankhwala aliwonse, Maninil ali ndi zotsutsana zingapo kuti agwiritse ntchito.

Milandu ikuluikulu yomwe imagwiritsidwa ntchito ngati mankhwala ndi awa:

• wodwalayo amakhala ndi chidwi chokwanira cha thupi ku glibenclamide kapena zigawo zina za mankhwala,
• wodwalayo hypersensitivity kuti amachokera ku sulfonylurea,
• kukula kwa wodwala ndi mtundu 1 matenda a shuga,
• matenda ashuga ketoacidosis, kukula kwa zizindikiro za khansa yodwala matenda ashuga,
• kuzindikira kwa chiwindi kwambiri mulephera wodwala,
• kulephera kwambiri kwaimpso
• kuzindikira kwa leukopenia,
• kuphwanya kwakukulu pakugwira ntchito pakataya chakudya,
• kukhalapo kwa chibadwa chosalolera cha wodwala lactose,
• nthawi ya bere ndi mkaka wawo,
• zaka wodwala zafika 18.

Chenjezo makamaka liyenera kuthandizidwa popereka mankhwala ngati wodwalayo awonetsa kukhalapo kwa matenda a chithokomiro omwe amayambitsa kuphwanya kwa magwiridwe antchito.

Kupanga, zikuwonetsa ndi contraindication pakugwiritsa ntchito Metformin

Metformin ndi piritsi lozungulira, la biconvex lokongola. Mapiritsiwa adawakumba ndi akunja ndi zokutira enteric.

Chofunikira chachikulu cha mankhwalawa ndi metformin hydrochloride.

Kuphatikiza apo, kapangidwe ka mankhwalawa kamaphatikizanso magawo ena ambiri owonjezera omwe amagwira ntchito yothandizira.

Zothandiza pazinthu izi zimaphatikizapo izi:

1. Povidone.
2. Wowuma chimanga.
3. Crospovidone.
4. Magnesium wakuba.
5. Talc.

Zigobazi zili ndi zinthu zotsatirazi:

• methaconic acid
• methyl methacrylate kopolymer,
• macrogol 6000,
• titanium dioxide
• talcum ufa.

Zizindikiro zazikulu zogwiritsira ntchito mankhwalawa ndi izi:

1. Kukhalapo kwa matenda a shuga a mtundu wachiwiri, posafuna kukhala ndi ketoacidosis, pakadalibe mankhwala othandizira pakudya.
2. Mankhwalawa mtundu 2 matenda a shuga kuphatikiza ndi insulin, makamaka pamaso pa kutchulidwa kwa kunenepa kwambiri, komwe kumayendera limodzi ndi kuwoneka kwachiwiri kwa insulin.

Zoyipa pa Metformin ndi:

• kukhalapo kwa precoma, chikomokere, kapena ngati matenda ashuga a ketoacidosis apezeka,
• kupezeka kwa vuto laimpso,
• chizindikiritso cha matenda opweteka kwambiri omwe akuwonekera ndikuwoneka kuti ali pachiwopsezo chachikulu chokhala ndi vuto la impso,
• dziko lamatenda am'madzi, malungo, matenda akulu, dziko lafa ndi njala.
• The kukhalapo kwa thupi la matenda pachimake ndi matenda omwe angayambitse kuwonongeka kwa mpweya kufa kwa zotumphukira minofu maselo,
• ntchito chiwindi,
• uchidakwa, chakumwa choledzeretsa chachikulu,
• kukula kwa zizindikiro za lactic acidosis,
• kugwiritsa ntchito zakudya zamafuta ochepa,
• nthawi ya bere ndi mkaka wawo,

Chowonjezera chotsutsana ndi kuchuluka kwa wodwalayo komwe kumagwiritsa ntchito mankhwala.

Pharmacological katundu wa Metformin

Kugwiritsa ntchito mankhwalawa kumathandizira kuti muchepetse gluconeogenesis m'magazi a chiwindi komanso kumachepetsa kuthana ndi shuga kuchokera m'matumbo a lumen. Mankhwala amathandizira chidwi cha zotumphukira zomwe zimadalira maselo a insulin.

Metformin sangathe kukopa maselo a minyewa yopanga insulin. Kugwiritsidwa ntchito kwa mankhwalawa sikumupangitsa kuti muwonekere zizindikiro za hypoglycemia m'thupi la wodwalayo.

Kukhazikitsidwa kwa Metformin mthupi kumatha kuchepetsa zomwe zili triglycerides ndi otsika osalimba lipoproteins.

Kuphatikiza apo, mankhwalawa amathandizira kuchepetsa kapena kukhazikika kwa thupi. The bioavailability wa mankhwalawa ndi 50-60%. The pazipita kuchuluka kwa mankhwalawa pambuyo kukhazikitsidwa kwake m'thupi zimatheka pambuyo 2,5 maola. Metformin sikuti imagwira mapuloteni am'madzi, imatha kudzikundikira m'maselo a tiziwalo tosiyanasiyana, m'maselo a minofu, chiwindi ndi impso.

Kuchoka kwa mankhwalawa kumachitika osasinthika ndi impso. Kutha kwa theka-moyo kumapangika kuyambira maola 9 mpaka 12.

Mankhwala othandizira, kuphatikiza kwa Metformin ndi insulin kungagwiritsidwe ntchito.

Kugwiritsa ntchito kwa Maninyl pamaso pa zovuta zina zakuthupi m'thupi kumatha kupweteketsa wodwalayo chifukwa chowoneka ndi zotsatira zoyipa zambiri. Poyerekeza ndi Maninil, kuvulaza thupi la Metformin kumatsika kwambiri.

Kugwiritsa ntchito Metformin nthawi zambiri kumadzetsa kuwoneka kwa zovuta m'mimba mwa odwala. Mawonetseredwe oterewa ndi m'mimba ndi dyspepsia.

Mankhwala onse awiriwa ndi othandiza ngati agwiritsidwa ntchito molingana ndi malangizo ogwiritsa ntchito.

Kugwiritsa ntchito Metformin 850 ndikulimbikitsidwa ngati wodwala yemwe ali ndi matenda osokoneza bongo a mtundu wachiwiri ndi wonenepa. Kusankha kwamankhwala kumeneku kumachitika chifukwa cha momwe Metformin amakhalira ndi thupi - kuchepa kapena kukhazikika kwa thupi la wodwalayo.

Kanemayo munkhaniyi akukamba za zochita za Metformin.

Kodi bwino Maninil kapena Glyukofazh ndi chiyani?

Glucophage, mosiyana ndi Maninil, samangothandiza shuga wotsika magazi, komanso amapewa kupewa kukula kwambiri kwa matenda ashuga. Komabe, zokonda ziyenera kuperekedwa kwa mankhwala oyambirirawo, osati mawonekedwe ake. Mutha kuyang'ananso ndi mankhwala a Glucofage Long.

Zinthu zodziwika bwino

Metformin ndi manninil - mankhwala ochizira matenda a shuga a 2. Amadziwika ndi katundu wa hypoglycemic, amagwiritsidwa ntchito kuchepetsa shuga m'magazi am'magazi.

Mankhwalawa onse angagwiritsidwe ntchito mosiyana ndipo ngati kuli kotheka, mu zovuta zovuta pogwiritsa ntchito mankhwala ena omwe amagwirizana. Onsewa a metformin ndi mannilol amathandiza kwambiri pa matenda a shuga 2, molingana ndi malangizo ogwiritsira ntchito komanso malingaliro a dokotala.

Mankhwala amapezeka kokha mwanjira ya mapiritsi okhala ndi mitundu yosiyanasiyana ya zinthu zomwe zimagwira.

Kodi mungasinthe bwanji Maninil ngati sagwira ntchito?

Ngati kapamba asiya kutulutsa insulini, kutenga Maninil sikudzakhala ndi zotsatira zomwe mukufuna. Izi zikutanthauza kuti matendawo akupita patsogolo. Wodwala akapanda kupita kwa dokotala ndipo samayamba kulandira jakisoni wa insulin, ndiye kuti afa chifukwa cha zovuta za matenda ashuga.

Kusiyana pakati pa mannil ndi metformin

Mankhwala ochepetsa shuga - mannin ndi metformin - ndi osiyana pakapangidwe, kachitidwe ka thupi ndi kachipangizidwe kochepetsera magazi.

Metformin ndi ya Biguanides. Imatsitsa shuga m'magazi mwa kuletsa kuyamwa kwake m'chiwindi. Mankhwalawa amayambitsa enzyme yapadera yomwe imalepheretsa shuga kulowa m'magazi. Mankhwala satenga gawo lililonse pakukhazikitsa insulin.

Mankhwala omwe ali ndi maninyl ndi glibenclamide. Imalimbikitsa kupanga insulin m'matumba mwa kutseka njira za potaziyamu m'maselo a beta. Ndi Maninil mankhwala, kuwunika mosamala kuchuluka kwa shuga m'magazi kumafunika kuti mankhwalawo asinthidwe moyenera komanso kukhalabe ndi chithandizo.

Mankhwala onsewa akuwonetsa zovuta zingapo. Kwa manila, izi ndi: hypoglycemia, fever, nseru, kupaka khungu ndi mucous nembanemba, zotupa, chiwindi. Metformin ili ndi mndandanda wocheperako wosonyeza mawonekedwe oyipa atatha kumwa mankhwalawo, omwe amawasiyanitsa bwino poyerekeza ndi mannil. Njira yayikulu, koma yofala kwambiri, yamtundu wa metformin imakwiya m'mimba thirakiti (kutsegula m'mimba, kusanza, matumbo a colic, flatulence).

Poyerekeza ndi maninil, metformin imakhala yothandiza kwambiri kupewa matenda a matenda ashuga. Ndi kugwiritsa ntchito pafupipafupi, mankhwalawa amalimbitsa thupi, komanso amathandizira kuchepetsa.

Mndandanda wa contraindication ogwiritsira ntchito mankhwalawa onse ndi ofanana, kupatula kuti glibenclamide siikugwiritsidwa ntchito kwa odwala matenda a shuga.

Kodi mapiritsi olimba kuposa Maninil ndi ati?

Maninil ndi mankhwala amphamvu kuti muchepetse shuga. Ngati yasiya kugwira ntchito, ndiye kuti wodwalayo amafunika jakisoni wa insulin. Palibe mankhwala ena omwe angathandize.

Odwala akuwonetsa kuti Maninil ndi mankhwala okwera mtengo. Chifukwa chake, chisankho chimakonda kumugwera.

Mutha kupeza ndemanga pankhani yoti zaka zingapo atayamba kuyang'anira, Maninil asiya kuchitapo kanthu. Komabe, palinso ndemanga zabwino za mankhwalawa.

Za adotolo: Kuyambira 2010 mpaka 2016 Othandizira pachipatala chachipatala chapakati chaumoyo Na. 21, mzinda wa elektrostal. Kuyambira mu 2016, agwira ntchito ku malo ozindikira matenda No. 3.

Zopezeka muzapulasitiki: zowona ndi zabodza!

10 zithandizo zachilengedwe za nyamakazi, mphamvu yake yomwe imatsimikiziridwa mwasayansi

Matenda a shuga ndi kuphwanya kagayidwe kazakudya zomanga thupi ndi madzi mthupi. Zotsatira za izi ndikuphwanya ntchito za kapamba. Ndiye kapamba yemwe amatulutsa timadzi timene timatchedwa insulin. Insulin imakhudzidwa pokonza shuga. Ndipo popanda icho, thupi silingakwanitse kusintha kwa shuga kukhala shuga.

Chithandizo chothandiza kwa matenda ashuga ndi kulowetsedwa kwa zitsamba zamankhwala. Kuti mukonzekere kulowetsedwa, tengani theka kapu ya masamba a masamba, supuni ya maluwa ocheperako ndi supuni ziwiri za masamba a quinoa. Thirani zonsezi ndi madzi okwanira 1 litre a madzi owiritsa kapena owonekera. Kenako sakanizani bwino ndikupaka masiku 5 pamalo owala.

Ambiri amanyalanyaza kufunikira kwa zakudya zoyenera mu zovuta zamankhwala zilizonse. Pankhani ya matenda ashuga, makamaka mtundu wachiwiri, izi siziyenera kutsutsidwa konse. Kupatula apo, zimakhazikitsidwa ndi vuto la metabolic, lomwe limayambitsidwa ndendende ndi zakudya zosayenera.

Osangokhala shuga mu lingaliro lokhazikika la mawu omwe ali ndi chiwopsezo kwa odwala matenda ashuga. Zakudya zokhazikika, ndipo zakudya zilizonse zopatsa mphamvu zamagulu, zimapangitsa kuwerengera kwamamita kumawonekera.

Chimodzi mwazomwe chimadandaula m'matenda ambiri ndi pakamwa pouma. Awa atha kukhala matenda am'mimba, matenda a pachimake a ziwalo za celiac, omwe amafunika chithandizo cha opaleshoni, matenda amtima ndi wamanjenje, matenda a metabolic ndi endocrine, komanso matenda a shuga.

Ndi mankhwala ati omwe ali bwino?

Maninil ndi metformin ali ndi zabwino komanso zovuta zingapo zomwe ziyenera kukumbukiridwa mukavomereza dongosolo la chithandizo chamankhwala. Kuti mukwaniritse chithandizo chokwanira kwambiri, ndikofunikira kuganizira za wodwala aliyense payekhapayekha, ndikupereka chidwi chake pamagulu a munthu wina.

Metformin imakhala ndi shuga yochepetsa thupi, yomwe imadziyimira pawokha pa insulin. Mukamamwa, mwayi wochepa wokhala ndi hypoglycemia. Chifukwa chake, panthawi yokhazikika pancreatic ntchito, mulingo wokwanira wa peptide hormone, maubwino a metformin alibe chilichonse

Matenda a shuga si sentensi. Awa ndi matenda omwe amafunikira mankhwala osalekeza, zakudya ndi zochita zina zolimbitsa thupi. Ngati mutsatira malangizo onse a dokotala, munthu akhoza kukhala moyo wonse.

Maninil ndi metformin ndi mankhwala omwe nthawi zambiri amaperekedwa pochiza matenda ashuga. Kuti mudziwe zamtundu wanji wa zida zachipatala zofunika pazochitika zina, ndikofunikira kuyesedwa.