Simvastol: malangizo ogwiritsira ntchito, analogi, mtengo, ndemanga

Mankhwala ndi osagwira. lactonezimagwirizana ndi zopangidwa kuchokera Aspergillus terreus. Pakupanga kagayidwe, hydroxy acid derivative imapangidwa yomwe imalepheretsa HMG-CoA reductasecatalyling isanayambike mapangidwe kupitiliranawo gawo loyambirira la kaphatikizidwe cholesterol. Nthawi yomweyo, kumwa mankhwalawa sikuyenda limodzi ndi kudzikundikira m'thupi zitsulo. Mothandizidwa simvastatin kuchuluka kwa thupi kumachepa lipoprotein kachulukidwe kakang'ono triglycerides ambiri cholesterol. Nthawi yomweyo, mulingo ukuwonjezeka lipoprotein kukwera kwambiri. Zotsatira za odwala ambiri zimawonekera pakatha masiku 10-14 kuyambira pachiwonetsero cha makonzedwe ndikufika pachimake patatha miyezi 1-1,5. Mutatha kumwa mankhwalawo, zomwe zili cholesterol amabwerera pamlingo wake wakale pang'onopang'ono.

Pharmacokinetics

Simvastatin imatenga bwino, magazi ambiri amawonedwa pafupifupi maola awiri. Kugwirizana kwakukulu ndi mapuloteni amwazi - pafupifupi 95%. Kusinthika mu chiwindi kuti apange beta hydroxyl acidndi mkulu mankhwala. Kuchotsa hafu ya moyo wa metabolites pafupifupi maola awiri. Amawachotsa ngati ma metabolites kudzera m'matumbo ndikuchepetsetsa kudzera impso.

Zizindikiro zogwiritsidwa ntchito

• Hypercholesterolemia: Mitundu ya IIa ndi IIb ya hypercholesterolemia yoyambira pakadalibe zotsatira za mafuta ochepa a cholesterol komanso njira zopanda mankhwala (kuchepa thupi, zolimbitsa thupi) kwa odwala omwe ali pachiwopsezo chotenga atherosulinosis zophatikizika zamtima, zosasinthidwa ndi zakudya komanso zolimbitsa thupi hypertriglyceridemia ndi hypercholesterolemia,
• Matenda a mtima: kuchepetsa chiopsezo cha kufa pambuyo myocardial infaration, kuchepetsa chiopsezo cha kusokonezeka kwa mtima wamatumbo (sitiroko), chepetsani ntchito yachitukuko atherosulinosis zombo zapamadzi.

Contraindication

Kuzindikira kwambiri mankhwala. myopathymatenda a chiwindi mimba, wazaka 18. Gwiritsani ntchito mosamala odwala ochepa hypotensionat khunyumutatenga immunosuppressantsndi aakulu uchidakwamatenda opatsirana pachimake, ndikuphwanya mulingo wamagetsi wamadzi, pambuyo povulala kapena maopaleshoni.

Zotsatira zoyipa

Kusanza, kusanza, kupweteka kwam'mimba, chisangalalo, kutsegula m'mimbakudzimbidwa kapamba, chiwindi, chizungulire, mutuminofu kukokana, asthenic syndrome, kusowa tulo, paresthesia, mitsemphakulakwa myalgiakufooka minofu kukokana zithunzi, eosinophiliakukweza ESR, thrombocytopeniathupi lawo siligwirizana kuchepa magazi, kuchepa kwa potency, kutulutsa khungu, palpitations.

Simvastol, malangizo ogwiritsira ntchito (Njira ndi Mlingo)

Kuchiza ndi mankhwalawa kuyenera kuchitika motsutsana ndi maziko a kudikirira kwa wodwalayo zakudya zama hypocholesterol. Mapiritsi a Simvastol ayenera kumwedwa nthawi imodzi patsiku, osalumikizana ndi kudya, makamaka madzulo, kutsukidwa ndi madzi.

Chithandizo hypercholesterolemia - mlingo woyambirira ndi 10 mg ndipo mtsogolomo, kusankha kwa mankhwalawa kumayenera kuchitika pakatha milungu 4 iliyonse. mulingo woyenera kwambiri amawona odwala ndi mlingo wa 20 mg / tsiku. Mlingo waukulu patsiku suyenera kupitirira 80 mg.

Kuthandiza odwala Matenda a mtima wa Ischemic - Mlingo wothandiza wa mankhwalawa ndi 20-40 mg / tsiku. Kusintha kwa Mlingo kumachitika pamwezi; malingana ndi zisonyezo, mlingo umatha kupitilizidwa mpaka 40 mg patsiku. Okalamba odwala ndi odwala omwe ali ndi kulephera kwa aimpso kusintha kwapakati kwa digirii sikuchitika.

Kuphatikizika, mawonekedwe omasulidwa

Simvastol imapezeka pokhapokha ngati mapiritsi omwe ali ndi mitundu yosiyanasiyana yozungulira simvastatin - 10, 20 kapena 40 mamilimita. Amakhala ozungulira, okhala ndi mawonekedwe oyera, oyera pachimake. Kunja kwa mapiritsiwa ndi zokutira, utoto wa mitundu yosiyanasiyana:

• 10 mg pinki
• 20 mg chikasu
• 40 mg ndi zofiirira.

Simvastol imatulutsidwa pamaziko a simvastatin, omwe ndi chinthu chokhacho chogwiritsa ntchito mankhwalawa. Zomwe zimatsalira zimapatsa misa, kukonza mayamwidwe, zimathandizira kusungidwa kwakutali. Awa ndi ma citric ndi ascorbic acid, shuga mkaka, microcrystalline cellulose PH101, magnesium stearate, butylhydroxyanisole. Pa chipolopolo, wopangayo amagwiritsa ntchito zokutira za Opadray II, kapangidwe kake kamene kamapangidwira mosiyanasiyana mosiyanasiyana.

Zotsatira za pharmacological

Mapiritsi a Simvastol amodziwika ngati odziletsa a HMG-CoA reductase. Izi zikutanthauza kuti gawo lake, sevastatin, limalumikizana ndi chinthu chofotokozedwa mosamala. Pankhaniyi, enzyme HMG-CoA reductase. Malinga ndi malangizo, zotsatirapo zina zonse za kumwa mankhwalawa ndi zotsatira zakutseka limodzi kwa mankhwala. HMG-CoA reductase enzyme imayenera kuyambitsa gawo limodzi mwamagawo a cholesterol synthesis. Pokhala ndi mawonekedwe ofanana, simvastatin imaphatikizidwanso mumtundu wa kusinthika kwa mankhwala m'malo mwa enzyme. Koma popeza kapangidwe kake ndi kosiyana, momwe amapangira cholesterol samapitilira kuposa izi. HMG-CoA yosagwiritsidwanso ntchito imasweka kukhala acetyl-CoA, chinthu chomwe thupi limagwiritsa ntchito kupanga mphamvu ndi zina zambiri.

Kuletsa chingwe chimodzi chokha cha zinthu zomwe zimapangitsa kuti zinthu zisinthe. Choyamba, kuchuluka kwa cholesterol yathunthu (OH) kumatsika. Poyankha kuchepa kwa mulingo wake, kuchuluka kwa ma lipoproteins otsika kwambiri, otsika kwambiri (LDL, VLDL), mafuta a triglyceride (TG) amatsika. Kuphatikizika kwakukulu kwa izi metabolites zamafuta kagayidwe kumayambitsa kupanga mapangidwe pazitseko zamitsempha yamagazi. Ndiye akuyamba chitukuko cha atherosclerosis. Chikwangwani choyambirira chimakhala chaching'ono popanda kukula, popanda kuwononga thanzi. Pamene ikukula, kuwundikira kwa chotengera kumacheperachepera, mpaka kufikira kwake kwathunthu. Choopsa kwambiri ndizosakanikirana zam'mitima ya mtima. Gawo lake litataya magazi ake, maselo ake amafa - myocardial infarction imayamba.

Koma pali lipoprotein "zabwino" m'thupi - HDL. Amathandizira kukweza mafuta m'thupi m'makoma amitsempha yamagazi. Kugwiritsa ntchito simvastol kumawonjezera chidwi chawo. Kuphatikiza pa kukula kwathunthu, kumachepetsa kuchuluka kwa LDL / HDL, OH / HDL. Kusintha konseku kumathandiza kuchepetsa ngozi ya mtima.

Simvastatin imayamwa mwachangu m'mimba. Pambuyo pa maola 1.3-2.4, kuphatikiza kwakukulu kumadziwika. Zotsatira zoyambirira zogwiritsidwa ntchito ndi Simvastol zalembedwa pambuyo pa masabata awiri. Kuunikira kwa ntchitoyi kumachitika pambuyo pa milungu isanu ndi umodzi kuyambira poyambira kukhazikitsidwa, pomwe mphamvu ya mankhwalawo ikufika pazokwanira zake. Pachifukwa ichi, wodwalayo amapereka magazi kuti awunikidwe.

Simvastol: Zizindikiro zogwiritsidwa ntchito

Malangizo a Simvastol akutsimikizira kuti apereke mankhwala ngati mankhwala a hypercholesterolemia, ngati cholesterol singakhale yofanana ndi chakudya, masewera olimbitsa thupi. Izi zikugwiranso ntchito pamavuto a cholesterol metabolised omwe apezeka komanso obadwa nawo.

Mapiritsi a Simvastol agwiritsidwa ntchito popewa mtima wamitsempha yamagazi, yomwe imakhazikitsidwa pakupanga mapangidwe a atherosranceotic. Pangozi ndi odwala omwe ali ndi matenda a mtima, matenda a shuga. M'magulu a anthu awa, mankhwalawa amatha kuchepetsa:

• kufa kwa concomitant mtima pathologies,
• chiwopsezo cha matenda a mtima, sitiroko,
• kufunika kwa kudula miyendo mu matenda ashuga,
• coronary artery atherosulinosis rate rate,
• chiwopsezo cha opaleshoni yotsitsimutsa.

Njira ya ntchito, Mlingo

Simvastol asanaikidwe, wodwalayo amaphunzira njira yotsitsira mafuta kuti achepetse cholesterol. Ngati sizibweretsa kufunika, mumapatsidwa mankhwala. Imagwira ntchito yothandiza. Chifukwa chake, kugwiritsa ntchito Simvastol popanda kudya sikothandiza.

Chakudya sichikhudza mayamwidwe a simvastatin. Chifukwa chake, kumwa mankhwalawa sikungagwirizane ndi chakudya. Mapiritsi a Simvastol amatengedwa mkati, kamodzi patsiku, madzulo.

Chithandizo chimayamba ndi milingo yocheperako, poganizira matenda omwe ali nawo, mkhalidwe wa wodwala, mankhwala omwe amamwa. Kamodzi pakatha milungu 4 kapena kuchepera apo, adokotala amawunika za matendawo. Ngati ndi kotheka, amasintha mlingo. Kutalika kwa mankhwalawa ndi Simvastol ndi payekha ndipo amatsimikiza ndi dokotala.

Mankhwala a hypercholesterolemia, mankhwalawa amatengedwa pa mlingo wa 10 mpaka 80 mg. Ndikulimbikitsidwa kuti muyambe kulandira chithandizo ndi 10 mg, ndikuwonjezera pang'onopang'ono mlingo monga tafotokozera pamwambapa. Kwa odwala ambiri, mlingo woyenera ndi 20 mg.

Ndi chibadwa cha cholesterol kagayidwe kachakudya, tsiku lililonse mlingo ndi 40 mg kamodzi kapena 80 mg mu magawo atatu ogawanika (20 mg aliyense m'mawa, masana ndi 30 madzulo).

Kugwiritsa ntchito Simvastol pochizira matenda a mtima a mtima kumathandizira pa 20-25 mg / tsiku. Malangizo oyambilira amalimbikitsa kuyambira 20 mg.

Mukuwonongeka kwambiri kwa impso, mogwirizana ndi danazol, vitamini B3 (≥1 g / tsiku), cyclosporine, gemfibrozil, mafupa ambiri amaletsa mlingo wa tsiku ndi tsiku wa Simvastol mpaka 10 mg. Anthu omwe amatenga verapamil, amiodarone sayenera kutenga 20 mg ya simvastatin.

Kuchita

Mankhwala ena akagwiritsidwa ntchito munthawi yomweyo ndi Simvastol amalimbikitsa chiopsezo chosinthika. Ena mwa iwo amaloledwa kugwiritsidwa ntchito pakuchepetsa mulingo wa simvastatin. Tidakambirana za iwo pamwambapa.

Simvastol yokhala ndi zoletsa zamphamvu za CYP3 A4 ndizotsutsana.

Mtengo wa simvastol umatengera mlingo, kuchuluka kwa mapiritsi omwe ali phukusi:

• 10 mg, 14 ma PC. - 120-203 rub.,
• 10 mg, 28 ma PC. - 118-230 rub.,
• 20 mg, 14 ma PC. - 210 ma ruble.,
• 20 mg, 28 ma PC. - 247-333 rub.

Mavuto a Simvastol ali m'mafakitala ambiri ku Russia. Mutha kufunsa wogulitsa zamankhwala kupezeka kwa mankhwalawa: Simgal (Israel), Zorstat (Croatia), Simvor (India), Avenkor (Russia), Holvasim (Korea) Wazilip (Slovenia), Sinkard (India), Zokor (Netherlands), Simvalimit ( Latvia), Simvageksal (Germany), Simvastatin (Russia). Zonsezi zili ndi yogwira mankhwala simvastatin.

Zinthu zomwe zidakonzedwa ndi olemba polojekitiyi
malingana ndi ndondomeko yakusinthaku.

Mawonekedwe ndi kipimo

Simvastol ndi m'gulu la mankhwala ochepetsa lipid. Chofunikira chake chachikulu ndi simvastatin, chomwe chili m'gulu la ma statins. Zowonjezera zake ndi: lactose monohydrate, citric acid, ascorbic acid, lactose, glycerol, magnesium stearate.

Kamodzi m'magazi am'magazi, zinthu zomwe zimapanga Simvastol zimachepetsa cholesterol "yoyipa", potero zimalepheretsa mapangidwe a sterols. Kuphatikiza apo, mankhwalawa amatha kuwonjezera kuchuluka kwa cholesterol "yabwino".

Amapangidwa ngati mapiritsi achikasu. Mapiritsiwo ali ndi mawonekedwe ozungulira, wokutidwa ndi chipolopolo chachikasu chachikaso ndimphete yosalala. Mugawo lalitali, magawo awiri amawoneka bwino: oyera mkati, ndi achikaso kumapeto.

Mlingo wa yogwira simvastine piritsi limodzi ndi 10, 20 ndi 40 mg. Dziko lopanga Romania ndi Russia. Dzina lamalonda malinga ndi tsamba la radar ndi Simvastol. Moyo wa alumali ndi zaka zitatu, zikuwonetsedwa pamimba.

Zotsatira zoyipa

Zotsatira zoyipa za mankhwala ophatikizira a statin zimaphatikizapo: kupweteka mutu, chizungulire, kusowa tulo, kusowa kwa matumbo, kupweteka kwa epigastric.

Nthawi zina, kuchulukitsa kwa kapamba, chiwindi chimagwira ntchito. Nthawi zina pamakhala thupi lawo siligwirizana ndi mankhwala omwe amaphatikizidwa ndi redness ndi kuyabwa.

Pafupipafupi, simvastol imatha kuyambitsa kagayidwe, kusintha kakomedwe, kamwa yowuma, myopathy, kuchuluka kwa nyamakazi, komanso kuchepa kwa ntchito ya minofu.

Mlingo ndi makonzedwe

Mlingo wa simvastol ndi 520 mg. Ngati ndi kotheka, zamavomerezedwe a adokotala, mutha kuwonjezereka ndi nthawi yayitali ya mankhwala anayi.

Mapiritsi nthawi zambiri amatengedwa kamodzi patsiku, ndi chakudya madzulo. Mapiritsiwo ayenera kumezedwa lonse osafuna kutafuna. Imwani madzi ambiri. Mlingo wololedwa kwambiri ndi 40 mg patsiku.

Kwa odwala omwe akutenga ma immunosuppressants, tikulimbikitsidwa kumwa mankhwalawa koyamba 5 mg, pafupipafupi ndi makonzedwe kamodzi patsiku. Kuti muchite izi, mutha kugawa piritsi ndi mulingo wa 10 mg magawo awiri. Mlingo wapamwamba kwambiri wa gulu ili la odwala sioposa 5 mg patsiku. Pankhani ya kupweteka kwambiri aimpso, muyezo mlingo ndi 5-10 mg patsiku. Ndi kuphatikiza kwa simvastol ndi verapamil ndi amiodarone, mlingo sayenera kupitirira 20 mg.

Kutalika kwa mankhwalawa ndi mankhwala kumatsimikiziridwa ndi dokotala. Pafupifupi, njira yochizira imatha mwezi umodzi, nthawi zina yayitali. Mapiritsiwo amayenera kumwedwa nthawi zonse komanso muyezo woyenera komanso pafupipafupi.

Mukamamwa mankhwalawa, yang'anani kuchuluka kwa cholesterol mu seramu yamagazi, komanso nthawi ndi nthawi mumayesa mayeso a chiwindi. Mukafuna njira zochizira zimatheka, mlingo umatha kuchepetsedwa.

Analogs of Simvastol

Ngati wodwalayo ali ndi vuto la Simvastol, dokotala amatha kusankha zina m'malo mwake pamaziko a ntchito - simvastatin. Pakati pazofanizira zazikulu zimatha kutchedwa mankhwala Ariescorp, Vasilil, Zokor.

Ndikosavuta kudziwa kuti ndi mankhwala ati abwinoko. Kusiyana kwawo kwakukulu mu dzina lazamalonda ndi kapangidwe kazinthu zina zowonjezera. Kuphatikiza apo, ma analogu ena amatha kukhala otsika mtengo.

Dokotala wokha ndiye amene angakusankhireni mankhwala oyenera.

Kugwiritsa Ntchito

Madokotala ambiri amazindikira kuchuluka kwa Simvastol. Chiwopsezo cha zovuta zina poyang'ana mlingo ndi malingaliro ake amachepetsedwa. Odwala omwe adathandizidwa ndi mankhwalawa amawona kulekerera kwake bwino, mtengo wotsika mtengo, komanso phindu labwino pazomwe amachita. Zotsatira zoyambirira za mankhwalawa zimatha kuyesedwa pambuyo pa milungu iwiri kapena itatu yoyendetsedwa.

Pamabwalo azachipatala odziwika bwino ndi zipata, palibenso ndemanga za Simvastol. Koma mutha kuwerengera ndemanga za mankhwala a Simvastatin, zomwe zimagwiritsidwa ntchito muzandalama izi ndizofanana.

Zambiri zamankhwala

Simvastol ndi wa gulu la mankhwala - ma statins, zoletsa za HMG CoA reductase. Othandizira oterewa ali ndi katundu wotsitsa lipid. Dzina losakhala lozungulira lapadziko lonse la Simavstol ndi simvastatin. Mankhwalawa amapangidwa ndi kampani yopanga zamankhwala a George Richter ku Romania.

Mankhwala amagwiritsidwa ntchito kuchepetsa kuchuluka kwa cholesterol yoipa yotsika pang'ono, cholesterol yathunthu ndi triglycerides. Nthawi zambiri amagwiritsidwa ntchito pochiritsa komanso mtima kuti achepetse kukulitsa matenda ophatikizika ndi zovuta.

Kutulutsa fomu, mtengo

Mankhwalawa amapezeka mu mawonekedwe a mapiritsi ang'onoang'ono ozungulira omwe amakhala ndi pinki. Iwalikeni m'matumba a pulasitiki okhala ndi zidutswa 14.

Kutengera ndi zomwe zili piritsi limodzi la Simvastol (10, 20 kapena 40 mg), mtengo wa mankhwalawa watsimikiza.Mtengo wapakati pama pharmac m'mizinda yayikulu ya Russia:

Mitengo yotsika mtengo imaperekedwa ndi malo ogulitsa pa intaneti. Atha kuyitanitsanso kutumiza kwa mankhwalawo ku adilesi yomwe yatchulidwa.

Zomwe zimagwiritsidwa ntchito zomwe ndi gawo la mankhwalawa ndikuzindikira mphamvu zake ndi simvastatin. Amatchedwa HMG CoA reductase inhibitors. Piritsi limodzi limakhala ndi 10, 20 kapena 40 mg pazinthu izi.

Zinthu zina zimagwira ntchito yothandiza. Pakati pawo - lactose, butylhydroxyanisole, ascorbic ndi citric acid, magnesium stearate, gelatin chimanga wowuma. Chiwerengero chawo chimawonjezeka potengera kuchuluka kwa simvastatin. Utoto wamtunduwu umakhala ndi utoto (wachikasu, wofiira ndi wakuda chitsulo oxide), macrogol, hypromellose, titanium dioxide ndi zinthu zina.

Zizindikiro ndi contraindication

Pali zizindikiro zapadera za kumwa mankhwalawa. Zina mwa izo ndi:

1. Hypercholesterolemia ya chikhalidwe choyambirira. Odwala omwe amapezeka ndi coronary atherosulinosis amadwala matendawa. Nthawi yomweyo, odwala ali pachiwopsezo chotenga matenda owopsa a mtima.
2. Kuphatikiza hypercholesterolemia.
3. Hypertriglyceridemia.

Pankhani ya ma pathologies oterowo, mankhwalawa amawonetsedwa pokhapokha njira zina zochiritsira sizinathandize - zakudya zapadera zomwe zimathandizira kuchepetsa milingo ya lipid, komanso masewera olimbitsa thupi omwe cholinga chake ndi kuchepa thupi.

Komanso, ma pathologies osiyanasiyana a mtima (mwachitsanzo, mtima ischemia) amasiyanitsidwa pakati pa zomwe zikuwonetsa. Mankhwala atha kuperekedwa:

• kupewa kukula kwa vuto la mtima,
• chepetsa ngozi yakumwalira kwa wodwala,
• chepetsani chiopsezo cha matenda a stroke kapena ischemic,
• kuchepetsa chiopsezo chobwezeretsa myocardial perfusion process (revascularization),
• Kuchepetsa makulidwe a atherosrance a zotupa zam'mimba.

Mankhwalawa ali ndi contraindication ndi malire ake. Siyenera kutengedwa motere:

• kusalolera kwa chimodzi kapena zingapo zomwe zimapanga mankhwala,
• Hypersensitivity to statins,
• chigoba minofu matenda (myopathy),
• matenda oopsa a chiwindi
• kuchuluka kwa chiwindi michere osadziwika.

Tiyeneranso kukumbukira kuti mankhwalawa sagwiritsidwa ntchito pochiza magulu amtunduwu:

1. Ana ndi achinyamata osakwana zaka zambirimbiri. Palibe kafukufuku yemwe adachitidwa pagululi, motero sizikudziwika kuti zotsatira za kugwiritsa ntchito mankhwalawa zingakhale chiyani.
2. Amimba Ngati amayi a msinkhu wobereka atenga Simvastol, ndiye njira zodalirika zakulera ziyenera kugwiritsidwa ntchito. Ngati muli ndi pakati, mankhwalawa amayenera kuperekedwa nthawi yomweyo.
3. Amayi oyamwitsa. Zinthu zomwe zimagwira zimatha kudutsa mkaka wa m'mawere ndikuvulaza mwana. Chifukwa chake, ngati kuli kotheka kutenga simvastatin, kuyamwitsa kuyimitsidwa.

Pali zoletsa zina zomwe mankhwalawo amagwiritsidwa ntchito mosamala kwambiri. Zina mwa izo ndi:

• kuthamanga kwa magazi
• kuvulala ndi ntchito zosiyanasiyana,
• uchidakwa
• kuphwanya kamvekedwe ka minofu, kupweteka kwa etiology yosadziwika,
• Kusokonezeka kwa chiwindi,
• kusokonezeka kwamagetsi,
• matenda a metabolic ndi endocrine,
• matenda opatsirana pachimake,
• kufalikira kwa ziwalo zamkati, pambuyo pake pakuyang'anira ma immunosuppressants,

Mankhwalawa ali ndi ma contraindication, omwe amayenera kulingaliridwa asanaikidwe. Nthawi zina, zimatengedwa mosamala.

Malangizo ogwiritsira ntchito

Malangizo ogwiritsira ntchito mankhwalawa akuwonetsa mfundo izi:

1. Mankhwalawa amayenera kutengedwa pakamwa kamodzi patsiku lisanayambe kapena chakudya (osati ndi zakudya!). Mapiritsi amayenera kumeza lonse ndi madzi.
2. Asanagwiritse ntchito, wodwalayo amapatsidwa zakudya zapadera, zomwe zimachepetsa kugwiritsa ntchito mafuta oyipa ndikuwathandiza kuti azichotsa m'thupi. Iyenera kuonedwa panthawi yonse yochizira.
3. Ndikofunikira kutsatira mlingo womwe dokotala wanu wakupatsani. Itha kumasiyana 10 mpaka 80 mg wa simvastatin patsiku. Mlingo waukulu kwambiri (80 mg) ndi woletsedwa kupitirira.

Ndi hypercholesterolemia, wodwalayo amamuika 10 mg ya mankhwalawa kuti ayambe nawo. Kupitilira apo, mulingo ungathe kuchuluka. Kusintha kwa Mlingo ndikotheka pambuyo pa mwezi wogwiritsidwa ntchito pafupipafupi. Kwa odwala ambiri, mlingo woyenera ndi 20 mg.

Ndi cholowa cha hypercholesterolemia, imodzi mwazinthu zimalingaliro:

• 40 mg kamodzi patsiku (nthawi yamadzulo),
• 80 mg mu atatu Mlingo wogawika.

Zofunika! Ngati wodwalayo ali ndi mtima ischemia kapena pali chiopsezo kwambiri cha chotulukapo chake, ndiye kuti wodwalayo adayikidwa 20-40 mg ya simvastatin. Ndi kuchepa kwa milingo ya lipid pambuyo poyeserera, mlingo umatha kuchepetsedwa. Odwala aukalamba kapena anthu omwe ali ndi matendawa aimpso sayenera kuchepetsa mlingo.

Ngati wodwala ali ndi vuto losalephera la impso kapena amatenga ma fakitrate, ma antidepressants, mankhwala a antihormonal, nicotinic acid, ndiye kuti mlingo wokwanira si woposa 10 mg patsiku. Mukamamwa Amiodarone kapena Verapamil, 20 mg yokha ya simvastatin imaloledwa. Mankhwalawa onse, akamamwa Simvastol, amathandizira kutenga myopathy.

Zotheka zoyipa ndi bongo

Mankhwalawa ali ndi zovuta zina. Zodziwika bwino ndi izi:

• kupweteka kwam'mimba, kutsekula m'mimba, kudzimbidwa, kugonja,
• kusanza ndi kusanza,
• mavuto a chiwindi
• asthenia
• kuphwanya kukoma ndi kuzindikira.
• dzanzi m'thupi
• mavuto a hematopoiesis (thrombocytopenia, kuchepa magazi, kuchuluka ESR),

Mankhwala osokoneza bongo siwokayikitsa, koma ngati mukugwiritsa ntchito mankhwalawa mankhwala ambiri, zotsatirapo zake zimakula. Pankhaniyi, chithandizo chamankhwala chimasonyezedwa. Mukhozanso kupanga chapamimba cha m'mimba, kutenga ma sorbyts kapena kugwiritsa ntchito hemodialysis.

Momwemonso

Pazifukwa zingapo, zomwe zimafanana ndi zomwe zimagwiritsidwa ntchito m'malo mwa mankhwalawa Simvastol. Ndizolimbitsa thupi (zimakhala ndi zinthu zomwezo) ndi othandizira omwe ali ofanana ndi kapangidwe ka kayendedwe. Madokotala nthawi zambiri amapereka:

1. Zokor. Mankhwala otchuka ochokera ku Netherlands. Zomwe zimagwiritsidwa ntchito ndi simvastatin. Mtengo - kuchokera ku 160 mpaka 320 ma ruble.
2. Simvageksal. Analogue yaumbidwe wa simvastol. Amapangidwa ndi kampani yaku Germany ya mankhwala a Salyutas Pharma. Amamasulidwa pamtengo wa 280-340 rubles.
3. Vasilip. Mankhwala othandiza kutsitsa a lipid okhala ndi simvastatin. Dziko lomwe adachokera - Slovenia. Mtengo wa mankhwalawo ndi ma ruble 250-550.
4. Simvastatin. Mankhwala apakhomo. Mtengo wake umachokera ku ma ruble 52 mpaka 95.

Kusankha njira zilizonse kapena kusinthana ndi zina zangofanana ndi kungokhala dokotala. Kudzichitira nokha mankhwala kumabweretsa zotsatirapo zoyipa.

Kutulutsa mawonekedwe ndi kapangidwe kake

Mlingo wa Simvastol ndi mapiritsi okhala ndi mafilimu: ozungulira, biconvex, pakati pa phalepo ndi loyera ndi mawonekedwe, chipolopolo ndi pinki (10 mg mg), chikasu (20 mg) kapena mtundu wa bulauni (mlingo wa 40 mg) (14 ma PC. chithuza, pamakatoni ambiri a matuza 1 kapena 2.

Piritsi limodzi lachifundo 1

• yogwira mankhwala: simvastatin - 10, 20 kapena 40 mg,
• othandizira zigawo: pregelatinized starch, lactose monohydrate, ascorbic acid, microcrystalline cellulose PH101, butyl hydroxyanisole, citric acid monohydrate, magnesium stearate,
• utoto wofiirira / wachikaso / zofiirira: Opadry II 33G24737 (lactose monohydrate, hypromellose, titanium dioxide, glycerol triacetate, macrogol, utoto wofiira wachitsulo, utoto wakuda wachitsulo, utoto wa aluminium oxide potengera utoto wa indigo carmine / / Opadry II 39G22514 (trirosetin, , titanium dioksidi, macrogol, lactose monohydrate, utoto wachikasu wachitsulo, utoto wachitsulo wofiira, utoto wakuda wachitsulo) / Opadry II 33G26729 (titaniyamu wa dixidole, macrogol, hypromellose, utoto wachikasu wachikopa, glycerol triacetate, utoto wonenepa. ndi wofiira oxide lactose monohydrate, chitsulo okusayidi wakuda utoto).

Bongo

Milandu ya bongo wa Simvastol wodziwika kwa akatswiri (mlingo waukulu womwe unatengedwa anali 450 mg) sizinayende limodzi ndi kuwonetsedwa kwa zizindikiro zenizeni. Monga chithandizo, chifuwa cha m'mimba ndi makala ophatikizidwa ndizofunikira. Syndrome dalili zimayitanidwanso ndipo kuchuluka kwa seramu CPK ndi kuwonongeka kwa impso ndi chiwindi kumayang'aniridwa nthawi zonse.

Ngati wodwala wayamba ndi myopathy ndi rhabdomyolysis ndi kupweteka pachimake mwamphamvu (zovuta koma zosagwirizana), ndikofunikira kusiya mankhwalawo ndikuyambitsa sodium bicarbonate komanso okodzetsa kwa wodwalayo kudzera kulowetsedwa kwa kulowetsedwa. Ngati ndi kotheka, hemodialysis imachitidwa.

Rhabdomyolysis ingayambitse hyperkalemia, yomwe imathetsedwa pogwiritsa ntchito mankhwala osinthanitsa a potaziyamu, kulowetsedwa kwa calcium calcium kapena calcium chloride, kulowetsedwa kwa shuga ndi kuwonjezera kwa insulin, kapena makamaka m'malo ovuta kwambiri a hemodialysis.

Malangizo apadera

Malinga ndi malangizo, Simvastol sayenera kutumizidwa kwa odwala omwe ali ndi chiopsezo chowonjezereka cha rhabdomyolysis ndi kulephera kwa aimpso. Zomwe zimayambitsa matendawa zimaphatikizira matenda oopsa, owopsa, opaleshoni yayikulu, zoopsa, zovuta zama metabolic.

Kugwiritsa ntchito mankhwalawa sikuwonetsedwa kwa mtundu I, IV ndi V hypertriglyceridemia.

Mankhwala a Simvastol ayenera kutsagana ndi kuwunika kwa chiwindi. Kafukufuku wokhudzana ndi ma enzymes a chiwindi amachitika musanayambe kugwiritsa ntchito mankhwalawa komanso nthawi zonse mukamapereka mankhwala: 2 masabata 6 aliwonse, kenako masabata 8 aliwonse mpaka kumapeto kwa chaka choyamba, kamodzi kamodzi miyezi isanu ndi umodzi. Chiyesero chofuna kudziwa ngati chiwindi chikugwiritsidwa ntchito pakuwonjezeka kwa mlingo uliwonse, komanso kudya 80 mg masabata aliwonse 12. Kukula kwakanthawi kwamlingo wa michere ya chiwindi ndikotheka kumayambiriro kwamankhwala. Ndi ntchito ya transaminase yopitilira katatu kuchuluka koyambirira ndikusungabe kuchuluka, mapiritsi ayenera kusiyidwa.

Odwala omwe ali ndi hypothyroidism ndi / kapena matenda a impso (kuphatikiza nephrotic syndrome) yokhala ndi cholesterol yokwanira amalimbikitsidwa kuti azitha kuchiza matenda oyambitsidwa.

Kuphatikiza pa monotherapy, kugwiritsidwa ntchito kwa mankhwalawo kumasonyezedwa limodzi ndi othandizira a bile acid.

Ndikulimbikitsidwa kupewa kugwiritsa ntchito nthawi yayikulu kuchuluka (kuposa 250 ml) ya madzi a mphesa, chifukwa ndizotheka kuwonjezera zovuta zoyipa za simvastatin.

Poyerekeza ndi kagwiritsidwe ntchito ka Simvastol, kukulitsa kwa myopathy, rhabdomyolysis ndi kulephera kwa aimpso ndikotheka. Zizindikiro za izi zimaphatikizira kupweteka kwa minofu, ululu wosaneneka, kufooka kapena kufooka kwa minofu, limodzi ndi malaise kapena kutentha thupi. Chiwopsezo chokhala ndi myopathy chikuwonjezereka ndikugwiritsa ntchito munthawi yomweyo mafrate (fenofibrate, gemfibrozil), nefazodone, cyclosporine, macrolides (clarithromycin, erythromycin), HIV proteinase inhibitors (ritonavir), antifungal agents a gulu la azole (itraconazole). Kuphatikiza apo, mwayi wokhala ndi myopathy ndiwopamwamba mwa odwala omwe amalephera kwambiri aimpso. Popereka mankhwala, dokotalayo ayenera kuchenjeza wodwalayo za kuthekera kwa matendawa, Zizindikiro zake komanso kufunika kolumikizana ndi katswiri ngati atakula.

Odwala omwe akukayikira kapena apezeka ndi myopathy, kuchotsa Simvastol ndikofunikira.

Odwala omwe ali ndi zaka zakubadwa ayenera kugwiritsa ntchito njira zodalirika zolerera panthawi yonse yomwe amamwa mankhwalawa. Mimba ikachitika panthawi ya chithandizo, mankhwalawa amasiya, ndipo mayiyo ayenera kuchenjezedwa za chiopsezo cha mwana wosabadwayo.

Kuthana kwa mankhwala a hypolipidemic pa nthawi ya pakati sikukhudza kwambiri zotsatira za nthawi yayitali ya hypercholesterolemia.

Ndi mawonekedwe a myalgia, myasthenia gravis ndi / kapena kuwonjezeka kodziwika mu zochitika za CPK, kugwiritsa ntchito Simvastol kuyenera kusiyidwa.

Ngati mwaphonya mwanjira yotsatira mwangozi, iyenera kumwedwa mukangokumbukira, izi sizitanthauza kuti mutenge mlingo waukulu nthawi imodzi.

Woopsa aimpso, mankhwala ayenera kuchitidwa powunika aimpso.

Wodwala amayenera kuwona zakudya za hypocholesterol asanayambe mankhwala komanso nthawi yonse ya kumwa Simvastol.

Zomwe zimapangitsa kuti wodwalayo athe kuyendetsa magalimoto ndi njira zake sizinakhazikitsidwe.

Kuyanjana kwa mankhwala osokoneza bongo

Chiwopsezo chowonjezereka cha myopathy chimayendetsedwa ndi kugwiritsa ntchito pamodzi kwa cytostatics, fibrate, immunosuppressants, nefazodone, erythromycin, clarithromycin, azole antifungals, HIV protease inhibitors, kuchuluka kwa nicotinic acid, telithromycin, kuphatikiza, pamiyeso yayikulu ya simvolatin - cycazine. amiodarone, verapamil, diltiazem.

The bioavailability wa simvastatin yafupika ndi colestipol ndi colestyramine, chifukwa chake, ndi concomitant therapy, kuti akwaniritse zowonjezera, simvastol sayenera kumwedwa pasanathe maola 4 pambuyo pofotokozedwera ndalama.

Mankhwala amawonjezera kuchuluka kwa digoxin m'madzi a m'magazi.

Simvastatin imawonjezera mphamvu ya anticoagulants mkamwa (kuphatikizapo fenprocoumone, warfarin) ndi chiopsezo chotaya magazi, motero, isanayambike chithandizo chophatikizana, ndikofunikira kudziwa magawo omwe wodwala amawagwiritsa ntchito ndikuwayang'anira pafupipafupi nthawi yoyambira. Atafika pamlingo wokhazikika wa prothrombin, amasinthana ndi njira yokhazikika yochiritsira ndi anticoagulants. Ngati musintha mlingo wa mankhwalawo kapena muleka kumwa, muyenera kugwiritsa ntchito pulogalamuyi yoyang'anira nthawi ya prothrombin.

Ndi monotherapy, simvastol siyimakhudza ma labotale magawo a prothrombin nthawi komanso chiwopsezo chowonjezeka magazi.

Madzi a mphesa amachulukitsa zochulukitsa zotsutsana ndi HMG-CoA reductase mu plasma yamagazi.

Analogs of Simvastol ndi: Aterostat, Holvasim, Vasilip, Simgal, Avestatin, Simplakor, Vero-Simvastatin, Simvor, Actalipid, Sinkard, Zokor forte, Simlo, Zovatin, Simvakard, Levomir, Simvastatin, Arieskor, Simvakor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor, Zorstor

Mtengo wa Simvastol m'masitolo ogulitsa mankhwala

Mtengo pafupifupi wa Simvastol 10 mg ndi ma ruble a 180-216. (pa paketi 28 yamapiritsi). Mtengo wa mapiritsi okhala ndi 20 mg wa avareji 280–320 ma ruble. (Mapiritsi 28 aphatikizidwa ndi phukusi).

Maphunziro: Yoyamba University State Medical University yotchedwa I.M. Sechenov, wapadera "General Medicine".

Zambiri zokhudzana ndi mankhwalawa ndizofanana, zimaperekedwa pazidziwitso ndipo sizilowa m'malo mwa malangizo aboma. Kudzipatsa nokha mankhwala kuopsa!

Pogwira ntchito, ubongo wathu umagwiritsa ntchito mphamvu zambiri zofanana ndi babu la 10-watt. Chifukwa chake chithunzi cha babu wapamwamba pamutu panu panthawi yomwe chikuwoneka ngati chosangalatsa sichili kutali ndi chowonadi.

Chiwindi chanu chikasiya kugwira ntchito, imfa imatha pakatha tsiku limodzi.

Munthu wophunzira sakhala wokonzeka kutenga matenda aubongo. Ntchito zaluso zimathandizira kuti pakhale ziwalo zina zowonjezera kulipirira odwala.

Munthu aliyense samangokhala ndi zala zapadera, komanso chilankhulo.

James Harrison wazaka 74 yemwe amakhala ku Australia amakhala wopereka magazi pafupifupi nthawi 1,000. Ali ndi mtundu wamagazi osafunikira, ma antibodies omwe amathandizira akhanda omwe ali ndi vuto lalikulu la magazi kukhala ndi moyo. Chifukwa chake, waku Australia adapulumutsa ana pafupifupi mamiliyoni awiri.

Malinga ndi kafukufuku wa WHO, kuyankhulana kwa theka la ola limodzi pafoni kumawonjezera mwayi wokhala ndi chotupa muubongo ndi 40%.

Vibrator woyamba adapangidwa m'zaka za zana la 19. Adagwira ntchito pa injini yankhonya ndipo adapangira kuti azitsatira khungu la akazi.

Munthu amene amamwa mankhwala opondeleza nthawi zambiri amakhalanso ndi nkhawa. Ngati munthu athana ndi kukhumudwa paokha, ali ndi mwayi wonse wakuyiwalako zamtunduwu mpaka kalekale.

Mankhwala akutsokomola "Terpincode" ndi amodzi mwa atsogoleri ogulitsa, ayi chifukwa cha mankhwala ake.

Ngati mungagwere kuchokera pabulu, mukulola khosi lanu kusiyana ndi kugwa kuchokera pa kavalo. Ingoyesani kutsutsa mawu awa.

Kuphatikiza pa anthu, cholengedwa chimodzi chokha padziko lapansi - agalu, omwe ali ndi vuto la prostatitis. Awa ndi abwenzi athu okhulupilika kwambiri.

Mankhwala ambiri poyamba anali ogulitsidwa ngati mankhwala osokoneza bongo. Mwachitsanzo, a heroin adagulitsidwa ngati mankhwala a chifuwa. Ndipo cocaine adalimbikitsidwa ndi madokotala ngati opaleshoni komanso ngati njira yowonjezerera kupirira.

Caries ndimatenda ofala kwambiri padziko lonse lapansi omwe ngakhale chimfine sangathe kupikisana nawo.

Mankhwala odziwika bwino "Viagra" adapangidwa poyambirira pochizira matenda oopsa.

Magawo anayi a chokoleti chakuda ali ndi zopatsa mphamvu pafupifupi mazana awiri. Chifukwa chake ngati simukufuna kukhala bwino, ndibwino kuti musadye zopitilira awiri patsiku.

Aliyense angathe kukumana ndi vuto lomwe limataya dzino. Izi zitha kukhala njira yomwe madokotala a mano amagwiritsa, kapena zotsatira za kuvulala. M'modzi ndi.

Zomwe zili mumafakisi?

Malangizo "Simvastola" ali ndi kufotokoza kolondola pakudzazidwa kwa paketi. Ngati pali kusiyana pakati pa deta zomwe zalembedwa ndi zomwe zilipo, muyenera kulumikizana ndi pharmacy kuti musinthe ma CD. Nthawi zambiri, mankhwalawa amakhala utoto wa pinki (10 mg) kapena wachikasu (20 mg). Chochitika chilichonse chimakhala chotchingidwa, chopangidwa ngati mozungulira bwalo. Zogulitsa ndizopanda pake, m'mphepete zimakhala zolimba. Mukadula mankhwalawa, mutha kuwona zigawo ziwiri: pakati ndi yoyera, m'mphepete ndi yopyapyala, pinki kapena wachikasu (kutengera mlingo wa gawo lomwe limagwira).

Malangizo a "Simvastol" amatchula kuti dzinalo ndi la gulu la lipid-kutsika. Chogwiritsidwacho chimapangidwa,, ndi chinthu chotentha cha Aspergillus terreus.

Momwe mungagwiritsire ntchito moyenera?

Wopangayo akuwunikira kuti Simvastol (zowunika zimatsimikizira izi) kumayambiriro kwa ntchito zingayambitse kuchuluka kwa ma enzymes a chiwindi. Pang'onopang'ono, vutolo limasinthidwa palokha, palibe njira zenizeni zofunika, palibe chifukwa chothana ndi mankhwalawo. Mwambiri, kulekerera mankhwala ndikwabwino, ndipo zovuta zosokoneza ndizosowa, ngakhale ndizotheka.

Monga pachiyambi pomwe chogwiritsidwa ntchito "Simvastol", ndipo pambuyo pake ndikofunikira kumayesedwa pafupipafupi kuti muwone ngati chiwindi chili bwino. Miyezi itatu yoyambirira ya chithandizo, kutsimikizika kwa michere ya organic kumachitika masabata 6 aliwonse, ndiye kuti nthawiyo imawonjezeka ndi milungu ina iwiri, kusunga izi kwa chaka chimodzi. Ndi kulekerera kwabwino ndi kupitiliza kugwiritsa ntchito mankhwalawa, mtundu wa chiwindi uyenera kuwunikiridwa kamodzi pachaka.

Zosintha pulogalamu

Monga tawonetsera mu ndemanga, "Simvastol" ikhoza kukhudza chiwindi, ngati dokotala akuvomereza kusintha mlingo wa mankhwalawa. Ngati dokotala wakupatsani kuchuluka kwa mankhwalawa, muyenera kupita ku chipatala pafupipafupi kuti muwone ngati zikuwonetsa bwanji chiwindi. Ngati mlingo ndi 80 mg, tikulimbikitsidwa kuyesedwa ndi miyezi itatu. Ngati kafukufuku awonetsa kupitiliza kuchita mopitilira muyeso wa hepatic transaminases, njira ya achire imatsirizika. Chizindikiro cha izi chidzakhala katatu kuwonjezerapo zizindikiritso zomwe zikuwonetsedwa pakuphunzira kwa thanzi la thupi. Komabe, monga ananenera odwala omwe amathandizidwa ndi Simvastol, kufunikira kochoka ndizochepa. Ngakhale ndikuwonjezeka kwa Mlingo watsiku ndi tsiku, mankhwalawa amaloledwa ndi thupi, samayambitsa mayankho olakwika.

Chisamaliro chapadera ndichofunikira

Mapiritsi a Simvastol (ma analogues omwe ali m'gulu la HMG-CoA reductase, nawonso) sanapangidwe kuti azigwiritsidwa ntchito ngati mwayi wa rhabdomyolysis ndi kulephera kwa impso ukuwonjezeka. Nthawi zambiri zinthu ngati izi zimayendera limodzi ndi matenda owopsa, hypotension, komanso kuvulala. Simvastol sayenera kugwiritsidwa ntchito ngati vuto lalikulu la metabolic ladziwika, ntchito yayikulu ikuyembekezeka posachedwa.

Poonetsa kugwiritsa ntchito "Simvastol" pamakhala kutchulidwa kwa hypercholesterolemia yoyamba. Ngati chithandizo chogwiritsa ntchito mankhwalawa chinali chokwanira, kusiya mankhwala chifukwa chokhala ndi pakati sikupangitsa kuti wodwala azindikire bwino.

"Zosangalatsa" malo

Ndemanga zakugwiritsa ntchito "Simvastol" lili ndi chidziwitso pofulumira kwa madokotala kuti asamwe mankhwalawa pakukonzekera. Mapangidwe omwe amalepheretsa ntchito ya HMG-CoA reductase imayambitsa kuchedwa kwa cholesterol mu minofu ya thupi, koma pawiri iyi, komanso zinthu zina zopangidwa ndimapangidwe ofunikira, ndizofunikira pakukula kwa mluza. Kugwiritsa ntchito "Simvastol" kungayambitse kupanga kolakwika kwa ma membrane a ma cell, maids. Ngati Simvastol imalembedwa kwa mayi panthawi yomwe mayi angathe kutenga pakati, njira zoteteza ziyenera kuchitika mpaka kumaliza maphunziro achire. Ngati amayi apezeka ndi pakati pa nthawi yamankhwala, Simvastol imathetsedwa, ndipo wodwalayo amadziwitsa zoopsa zonse zokhudzana ndi mimbayo.

Malangizo ogwiritsira ntchito "Simvastol" ali ndi malingaliro othandizira kuti asagwiritsidwe ntchito ndi chida ichi ngati wodwala wazaka zakubala sagwiritsa ntchito njira zakulera.

Zofunikira: gwiritsani ntchito mwanzeru

Malangizo ogwiritsira ntchito "Simvastol" ali ndi zisonyezo zamomwe odwala ena amathandizira. Ngati matenda a hypothyroidism apezeka, matenda a nephrotic apezeka, matenda ena a impso apezeka, Simvastol sayenera kutumizidwa mwachangu, mayeso atangowonetsa cholesterol yokwera m'magazi. Njira zoyenera ndizomwe zimayang'anira matenda omwe adalimbikitsa izi, ndipo atangochotsa, mutha kupita ku Simvastol kuti musinthe momwe wodwalayo alili.

Malangizo apadera akamagwiritsidwe ntchito "Simvastol" ali ndi anthu omwe akudwala mowa. Ndikofunika kuunikira pafupipafupi zizindikiritso zofunika za thupi kuti mupewe kuyankha molakwika mkati. Chisamaliro chapadera chimafunikira ndi matenda osiyanasiyana a chiwindi omwe wodwala adadwala, omwe atchulidwa m'mbiri yachipatala. Mwanjira zilizonse zomwe mungasankhe, kulandira chithandizo kumayendetsedwa ndi zakudya zosankhidwa bwino zomwe zimakhala ndi cholesterol yochepa.

Zowopsa ndi malamulo ovomerezeka

Malangizo ogwiritsira ntchito "Simvastol" salimbikitsa kudya msuzi wa mphesa nthawi yamankhwala ndimankhwala, chifukwa zimatha kuyambitsa zotsatira zoyipa. Anthu omwe akudwala myalgia, myasthenia amafunikanso chisamaliro chapadera. Mwambiri, kugwiritsa ntchito Simvastol ndikoletsedwa zoterezi. Kuchiza ndi mankhwalawa kuyenera kusiyidwa ngati Hypersensitivity kwa CPK iwonekera. Osagwiritsa ntchito ngati wodwala wavumbulutsa hypertriglyceridemia ya mtundu woyamba, wachinayi, wachisanu.

Monga analogues, choloweza mmalo mwa mankhwalawo, Simvastol ikhoza kuyambitsa thupi kugundana. Pali mwayi wokhala ndi myopathy, wolimbikitsa rhabdomyolysis, kulephera kwa impso. Kuchepa kwa zochitika zoterezi ndizokwera kwambiri ngati wodwala agwiritsa ntchito dzinalo nthawi yomweyo ndi mafupa, antimicrobial othandizira ochokera m'magulu a macrolides, cyclosporins, komanso nefazodone. Zowopsa zina zimakhudzana ndikugwiritsa ntchito munthawi yomweyo "Simvastol" ndi azole antifungal agents, HIV proteinase inhibitors. Myopathy imatha kusokonezeka pamene mukutenga Simvastol mwa odwala omwe amalephera kwambiri aimpso.

Dziwani ndi kumvetsetsa

Pakulimbikitsidwa kuti mutenge, molingana ndi malangizo "Simvastol", analogi yomwe ili m'gulu lomwelo la mankhwala, komanso muzochitika zomwe pakufunika pakuwonjezera kuchuluka, muudindo la dokotala ndikuwachenjeza wodwalayo za myopathy. Katswiriyu akuwunikirani chidwi chakuti matenda opweteka osafotokozeredwa omwe adawonekera atangoyamba maphunzirowo kapena kuwonjezeka kwa mulingo, komanso kumva zowawa, kufooka kwa minofu, kuperewera, ndi mwayi wofunafuna chithandizo choyenera nthawi yomweyo. Ndikofunika kwambiri kupita kuchipatala ngati matendawo akutha msanga kapena akuvutika ndi vuto lotupa. Zikakhala zotere, kulandiridwa kwa mankhwalawo kumayimitsidwa nthawi yomweyo. Kuletsa kumachitika mofanananso ndi myopathy, ndipo mukuganiza kuti izi zachitika.

Mukamagwiritsa ntchito Simvastol, cholowa m'malo mwa mankhwalawa omwe adasankhidwa ndi adotolo, muyenera kupita ku chipatala pafupipafupi kuti mukayesedwe kuti ayang'anire KFK. Izi zimathandiza kupewa myopathy. Zimadziwika kuti njira yogwiritsira ntchito mankhwalawa imatha kutsagana ndi kuwonjezeka kwa CPK mu seramu. Ngati akumva kupweteka pachifuwa, dokotala amaganizira izi. Mankhwalawa amathetsedwa ngati CPK ipitilira muyeso wa nthawi khumi kapena kuposerapo.

Momwe mungagwiritsire ntchito?

Monga tafotokozera mu malingaliro, malangizo ogwiritsira ntchito, Simvastol imagwira ntchito monga mankhwala okhawo ochiritsira wodwala komanso ngati chinthu chovuta kuchira. Zotsatira zabwino zimawonetsedwa ndi kuphatikiza kwa Simvastol ndi sequestrants za bile acid. Wopanga akutsimikizira kuti mukadumpha mlingo wotsatira, tengani voliyumu yomwe mwasowa posachedwa, koma osangowonjezera muyezo ngati kulumikizidwa kwadziwika ndi nthawi yomwe mukufuna kutenga gawo lotsatira. Ngati kugwira ntchito kwa impso ndi kovuta, Simvastol imayikidwa pokhapokha ngati kuyang'anitsitsa mosalekeza momwe thupi limagwirira ntchito. Kutalika kwa njira ya achire nthawi zonse kumatsimikiziridwa ndi adokotala, palibe maphikidwe apadziko lonse a izi. Dotolo amawunika momwe wodwalayo alili, matenda ake, njira zake, momwe thupi limathandizira pamankhwala, pamomwe amapanga nthawi yayitali bwanji.

Pakalipano palibe chidziwitso chomwe Simvastol chingasokoneze kudwala kwa wodwalayo kuti azikhala ndi nthawi yambiri. Palibe zotsatira pa kuchuluka kwa momwe angachitire. Palibe kusintha kwa moyo, kukana kuyendetsa galimoto panthawi yamankhwala kumafunika.

Malangizo aukadaulo

Monga akunenera malangizo, "Simvastol" ndi lactone yosagwira. Kamodzi m'thupi la munthu, chinthucho chimalowa mu hydrolysis reaction, chomwe chimagwira, chikuletsa HMG-CoA. Kuchita bwino kwa mankhwalawa kumachitika chifukwa choletsa kutembenuka kwa HMG-CoA kukhala mevalonate, ndipo izi ndi gawo loyambirira pakupanga cholesterol. "Simvastol" sichimapangitsa kudzikundikira kwa ma sterols mu minofu ya thupi, omwe akuyerekezeredwa ndi akatswiri kuti akhale olimbikitsa kwambiri - mankhwala omwe ali mgulu la oopsa. HMG-CoA imasinthidwa kukhala acetyl-CoA, chinthu chomwe chimakhudzidwa m'njira zosiyanasiyana mthupi la munthu.

Mayeso apadera awonetsa kuti phata lomwe limagwira limasungunuka bwino kwambiri. Mankhwalawa amafikira pakulowerera kwambiri m'thupi mwake pakangotha ​​ola limodzi ndi theka kuchokera pakulowetsedwa (nthawi zina amatenga mpaka mphindi 150), gawo limatsika ndi 90% pambuyo pa theka la tsiku. Mpaka 95% amalowa m'magulu okhazikika ndi plasma. Kuchotsa hafu ya moyo wa kagayidwe kachakudya pogwiritsa ntchito ndizosakwanira maola awiri. Oposa theka la mankhwala amaponyedwamo ndowe, pafupifupi 10-15% - ndi impso, mawonekedwe ake ndi osagwira ntchito.

Kodi chikuchitika ndi chiani mthupi?

Kugwiritsa ntchito moyenera mankhwalawa malinga ndi malangizo omwe amapezeka m'madzi a m'magazi, kuchuluka kwa LDL, VLDL, tizigawo ta triglyceride, ndi cholesterol yonse kumachepa. Izi zimapangitsa mankhwalawa kukhala othandiza mu mitundu yosakanikirana yamatenda, omwe si a banja, a heterozygous, ndiye kuti, nthawi zina pomwe ndizoyenera kuchuluka kwa cholesterol yomwe imayambitsa chiwopsezo chachikulu. HDL yoyenda mozungulira imakwera, ndipo kuchuluka kwa LDL kupita ku LAPA kumachepa. Chiwerengero cha kuchuluka kwa cholesterol ndi HDL chikuchepa. Mphamvu yokhazikika imawonedwa pakatha masabata awiri chiyambireni njira yochizira, yomwe imanenedweratu ndi sabata lachisanu (nthawi zina pang'ono kapena mochedwa). Kutalika kwa kanthu - njira yonse yothandizira achire. Pamapeto pa mankhwalawa, mafuta a cholesterol amabwerera pang'onopang'ono kuzikhalidwe zawo zoyambirira.

Mukasankhidwa

Otsatirawa poyerekeza ndemanga, malangizo ogwiritsira ntchito, "Simvastol" (analogues nawonso) amalimbikitsidwa kwa anthu omwe awulula mtundu wa hypercholesterolemia, pomwe zakudya sizikuwonetsa kusintha kwenikweni, ngakhale kudya mafuta a cholesterol bwino. Mankhwalawa amalimbikitsidwa ngati njira zina zochepetsera cholesterol concentration zimayesedwa, koma onse awonetsa kusakwanira ngakhale ali pansi pazinthu zochepetsera thupi ndikuwonjezera zochitika zolimbitsa thupi. Simvastol zotchulidwa pokhapokha pokhapokha ngati mwayi wa coronary atherosulinosis akuyerekezedwa pamwambapa. Itha kugwiritsidwa ntchito, ngati hypercholesterolemia ikakhazikitsidwa, kuchuluka kwa triglycerides kwamtundu wophatikizidwa. Mkhalidwe wofananowu ndi kusakwanira kwa zakudya, zolimbitsa thupi, zosagwiritsa ntchito mankhwala ena.

"Simvastol" imafotokoza mtima ischemia monga prophylactic yomwe imaletsa kugunda kwa mtima, imachepetsa chiopsezo cha kufa ndi ischemia. Kugwiritsa ntchito bwino mankhwala kungathandize kuchepetsa vuto la mtima, mtima. Chida chikuwonetsa kukhudzidwa makamaka ndi chiopsezo cha transistor kuukira kwa ischemia, stroke. Ngati atherosulinosis atapezeka, kugwiritsa ntchito Simvastol kumathandiza kuti muchepetse kupita patsogolo kwa matendawa ndikuchepetsa chiopsezo chosinthanso.

Kodi ndizotheka liti?

"Simvastol" sicholinga cha mankhwala aanthu omwe thupi lawo limamverera mphamvu pazomwe zimagwira, zinthu zina zomwe zimagwiritsidwa ntchito popanga mankhwalawa. Mndandanda wathunthu wazinthu zimaperekedwa pazomwe zimaphatikizidwa ndi piritsi. Simungagwiritse ntchito "Simvastol" ngati thupi la odwala sililekerera mankhwala a statin.Musanapereke mankhwala, ndikofunikira kupenda mwatsatanetsatane mbiri yakale ya chithandizo cha kasitomala.

Simvastol sinapangidwe kuti azichitira anthu omwe ali ndi matenda a chiwindi mwanjira ya kukokomeza, komanso ntchito yokhazikika ya ma enzymes a chiwindi pamtunda wabwinobwino, ngati etiology yasowa. Simungathe kugwiritsa ntchito mankhwalawa ngati porphyria, myopathy yakhazikika. Mankhwalawa sanapangidwire zochizira ana, palibe chidziwitso chakuthandiza kwa chithandizo chotere, chitetezo cha Simvastol kwa wodwala.

Kukhazikika ndiye chinsinsi cha chitetezo

Simvastol ikhoza kugwiritsidwa ntchito mosamala kwambiri ndi anthu omwe amamwa mowa. Pokhapokha moyang'aniridwa ndi dokotala pokhapokha ngati pakugwiritsiridwa ntchito chiwalo posamutsidwa kumene. Njira yokhayo imafunidwa ndi anthu omwe amamwa mankhwala omwe amapondereza chitetezo cha mthupi, popeza pali mwayi wokhala ndi ribdomiolysis, kulephera kwa impso. Ubwenzi wapadera umafuna munthu yemwe matenda ake akuwonetsa kuti ali ndi vuto la impso. Makamaka, izi ndizovuta pakugwira ntchito kwa endocrine gland, kagayidwe, matenda opatsirana kwambiri pachimake, hypotension.

"Simvastol" imagwiritsidwa ntchito mosamala ngati wodwala wakonzekera kuchita opareshoni, kuphatikizapo mano. Njira yofunikira ndi yofunikira ngati kusunthika kwa madzi kosintha pakhungu kusokoneza, kuvulala, matumbo osakwanira a minofu ndikudziwika, ndipo chomwe chimayambitsa matendawa sichingadziwike. "Simvastol" ndi yovomerezeka, koma moyang'aniridwa ndi dokotala, ngati wodwala akudwala khunyu.

Zambiri kapena zochepa?

Pakadali pano, pafupifupi ma ruble 300 amafunsidwa mundalama imodzi yamafunso omwe amafunsidwa m'mafakitore. Mtengo wake umatsimikiziridwa ndi kuchuluka kwa yogwira ntchito m'mapiritsi, mfundo yamitengo ya kampani yopanga mankhwala. Analogs a Simvastol amawonetsedwa onse okwera mtengo komanso otsika mtengo. Mwambiri, dzina lofotokozedwalo ndi la nambala ya ndalama zomwe zilipo kuchokera pagulu lake. Ngati pakufunika kusankha cholowa m'malo, madokotala nthawi zambiri amalimbikitsa kutengera mayina:

Mwa ena odalirika a Simvastol ndi Aterostat, Simvor, ndi Simplacor. Iwo ali osavomerezeka kuti azisankha nokha, izi zitha kuyambitsa kusowa kwa njira zochizira, zotsatira zoyipa, kuphatikizapo myopathy. Kugwiritsa ntchito mankhwala aliwonse, m'malo mwake ndi analogues kuyenera kuyanjanitsidwa ndi dokotala yemwe wakupatsani mankhwalawo.