Alpha lipoic acid

Mankhwala omwe amapanga - bi alpha lipoic acid, omwe amapezeka m'mankhwala ena, ali ndi mawonekedwe angapo ogwiritsira ntchito. Pulogalamuyi, yomwe imadziwika kuti ndi vitamini N kapena thioctic acid, imawonetsa ntchito ya antioxidant, imathandizira zochita za insulin, komanso imathandizira kupanga mphamvu. Lipoic acid pamapiritsi amathandizira kusintha magwiridwe antchito amthupi ofunikira osati kwa odwala okha, komanso kwa anthu omwe amakonda masewera.

Kodi alpha lipoic acid ndi chiani?

Thioctic acid idapezeka mu 1950 kuchokera ku chiwindi cha bovine. Imatha kupezeka m'maselo onse a chamoyo, momwe mumathandizira kupanga mphamvu. Lipoic acid ndi imodzi mwazinthu zazikulu pakufunika kwa shuga. Kuphatikiza apo, penti iyi imawonedwa ngati antioxidant - imatha kuteteza kusintha kwaulere komwe kumachitika munthawi ya oxidation ndikuwonjezera mphamvu ya mavitamini. Kuperewera kwa ALA kumawononga ntchito ya thupi lonse.

Lipoic acid (ALA) amatanthauza mafuta acids okhala ndi sulufule. Imawonetsa zofunikira za mavitamini ndi mankhwala osokoneza bongo. Mwanjira yake yabwino, thunthu ndi ufa wamkaka wachikasu wokhala ndi fungo linalake komanso kununkhira kowawa. Asidiyo amasungunuka kwambiri m'mafuta, ma alcohols, osowa m'madzi, omwe amachepetsa mchere wa sodium wa vitamini N. Pulogalamuyi imagwiritsidwa ntchito pokonza zakudya zowonjezera komanso mankhwala.

Zotsatira za pharmacological

Lipoic acid amapangidwa ndi khungu lililonse m'thupi, koma kuchuluka kwake sikokwanira pakugwira ntchito kwakanthawi kwamakina amkati. Munthuyo amalandira kuchuluka kwa zinthu zosowa kuchokera ku zinthu kapena mankhwala. Thupi limatembenuza lipoic acid kukhala gawo labwino la dihydrolipoic. ALA imagwira ntchito zingapo zofunika:

• Imachepetsa kufotokozera kwamitundu yomwe imayambitsa kukula kwa kutupa.
• Imalepheretsa kusintha kwakasinthasintha. Acid iyi ndi antioxidant yolimba yomwe imateteza maselo amthupi ku zinthu zowonongeka za oxidation. Kutenga gawo lowonjezera la bioactive poti kumathandizira kuchepetsa kapena kupewa zotupa, matenda ashuga, matenda a atherosulinosis ndi matenda ena akuluakulu.
• Kuchulukitsa chidwi cha maselo amthupi kupita ku insulin.
• Zimathandizira kulimbana ndi kunenepa kwambiri.
• Amachita nawo mitochondrial biochemical reaction kuti atenge mphamvu pakuwonongeka michere.
• Imasintha ntchito ya chiwindi chowonongeka ndi hepatosis yamafuta.
• Amayang'anira ntchito ya mtima, mitsempha yamagazi.
• Amabwezeretsa antioxidants a magulu ena - vitamini C, E, glutathione.
• Imayambiranso imodzi yofunika kwambiri ya coenzymes NAD ndi coenzyme Q10.
• Matendawa amagwiranso ntchito kwa T-lymphocyte.
• Zimagwira limodzi ndi mavitamini a gulu B zomwe michere ikulowa mthupi mu mphamvu.
• Amachepetsa shuga.
• Amamanga ndikulimbikitsa kuchotsedwa kwa mamolekyulu a zinthu zoopsa ndi zitsulo zolemera - arsenic, mercury, lead.
• ALA ndi cofactor wa michere ina ya mitochondrial yomwe imayamba ntchito yopanga mphamvu.

Zizindikiro zogwiritsidwa ntchito

Nthawi zina, pakugwira ntchito bwino kwa thupi, zinthu zomwe zimapezeka kuzinthu zomwe zimapangidwa ndi ma cell sizokwanira. Kugwiritsa ntchito lipoic acid m'mapiritsi, makapisozi kapena ma ampoules kumathandiza anthu kuchira msanga, kufooka chifukwa cha kulimbitsa thupi kwambiri kapena kudwala. Mankhwala, zomwe zili ndi ALA, zimakhala ndi zovuta. Malinga ndi akatswiri ambiri, amagwiritsidwa ntchito kwambiri pamasewera, zamankhwala komanso kuthana ndi kunenepa kwambiri.

Mndandanda wazisonyezo zamankhwala zokhudzana ndi ALA:

• mitsempha
• ubongo owonongeka,
• chiwindi
• matenda ashuga
• uchidakwa
• cholecystitis
• kapamba
• poyizoni ndi mankhwala, ziphe, zitsulo zolemera,
• matenda a chiwindi
• atherosulinosis ya ziwiya zamaona.

Chifukwa cha kuphatikiza kwamphamvu mphamvu, mankhwala okhala ndi thioctic acid angagwiritsidwe ntchito kuthana ndi kunenepa kwambiri. Kulimbitsa thupi kwa zinthu kumatha chifukwa cha kuchepa thupi pokhapokha pamasewera. ALA sikuti imathandizira njira yotentha mafuta, komanso kuwonjezera mphamvu ya thupi. Kukhalabe ndi thanzi labwino kumakupatsani mwayi wokukwaniritsa cholinga chochepetsa thupi komanso kukhala wathanzi mtsogolo. Lipoic acid pomanga thupi imagwiritsidwa ntchito pochira msanga komanso kutentha mafuta. Ndikulimbikitsidwa kuti mutenge ndi L-carnitine.

Malangizo ogwiritsira ntchito thioctic acid

Momwe mungagwiritsire lipoic acid pochiza komanso kupewa? Kutalika kwa mankhwala ndi vitamini N ndi mwezi umodzi. Ngati mankhwalawa amagwiritsidwa ntchito pakamwa, ndiye muyenera kumwa nthawi yomweyo mukatha kudya. Mankhwala, mankhwalawa amatchulidwa kuchuluka kwa 100-200 mg patsiku. Kuonetsetsa kupewa matenda a metabolic komanso kukula kwa matenda chaka chonse, mlingo wa mankhwalawa umachepetsedwa mpaka 50-150 mg. Woopsa, odwala zotchulidwa mlingo waukulu - 600-1200 mg tsiku lililonse. Acid iyi ndi chinthu chopanda vuto, koma nthawi zina imatha kuyambitsa chifuwa kapena m'mimba.

Malangizo ochepetsa thupi

Lipoic acid osakanikirana ndi zakudya zopatsa thanzi, komanso masewera olimbitsa thupi amathandizira kagayidwe ndipo amathandizira kuti achepetse anthu onenepa kwambiri. Kuti muchepetse kunenepa kwambiri, mlingo wa mankhwalawa umakulitsidwa malinga ndi momwe thupi liliri mutafunsa dokotala. Mankhwala oyamba amatengedwa pakudya m'mawa, chachiwiri ataphunzitsidwa, ndipo chachitatu ndi chakudya chamadzulo.

Lipoic Acid wa shuga

Zochizira matenda ashuga, mapiritsi okhala ndi izi kapena jakisoni wothandizirana amatha kupatsidwa mankhwala. Sitikulimbikitsidwa kumwa mankhwalawa pakudya, ndibwino kumwa pamimba yopanda kanthu. Mlingo wa mankhwala a shuga ndi 600-1200 mg tsiku lililonse. Njira zomwe zili ndi ALA zimalekeredwa bwino, koma nthawi zina mukatenga kuchuluka kwazomwe zimagwira, kuzungulira, kuyabwa, kutsekula m'mimba kapena kupweteka m'dera la epigastric kumawonedwa. Njira ya mankhwala ndi milungu 4, nthawi zina, mwa kusankha kwa dokotala, imatha kupitilizidwa.

Gwiritsani ntchito panthawi yoyembekezera komanso poyamwitsa

Mankhwala othandizawa amakhala ndi mankhwala otetezeka, koma amaletsedwa kugwiritsa ntchito amayi apakati ndi amayi oyamwitsa, chifukwa momwe mwana amakhudzidwira mwana sanabadwe. Panthawi yovuta, mankhwalawa omwe ali ndi ALA amatha kuperekedwa kwa odwala omwe akuyembekezera mwana ngati phindu lomwe lingachitike chifukwa limaposa kuvulaza komwe kungachitike kwa mwana. Kuyamwitsa mwana wakhanda panthawi ya chithandizo kuyenera kutha.

Alpha Lipoic Acid

Yogwira popanga ALA (alpha kapena thioctici acid) imapezeka m'mankhwala ambiri komanso zakudya zamagulu osiyanasiyana komanso mtengo. Amapezeka mu mawonekedwe a mapiritsi, makapisozi, onjezerani ma ampoules ophatikizira makonzedwe. Mankhwala okhala ndi ALA:

• Malipidwe,
• Lipamide
• Lipothioxone
• Neuro lipone
• Oktolipen
• Tiogamma
• Thioctacid
• Tiolepta
• Thiolipone.

Zowonjezera zomwe zimakhala ndi thioctic acid:

• NCP Antioxidant,
• ALK kuchokera kwa Asisitikali,
• Gastrofilin kuphatikiza
• Microhydrin
• Chiwopsezo cha Alphabet,
• Kuyerekeza Matenda A shuga ndi zina zambiri.

Kuyanjana kwa mankhwala osokoneza bongo

Zotsatira zakuchiritsira zamagulu zimapangika bwino zikagwiritsidwa ntchito limodzi ndi mavitamini a B, L-carnitine. Mothandizidwa ndi acid, insulin yokhala ndi mankhwala omwe amachepetsa shuga amayamba kugwira ntchito. Jekeseni wa thunthu sayenera kuphatikizidwa ndi mayankho a shuga, fructose ndi shuga wina. ALA imachepetsa mphamvu ya zinthu zomwe zimakhala ndi ayoni ayoni: chitsulo, calcium, magnesium. Mankhwalawa ngati onsewa adanenedwa, ndiye kuti maola 4 azikhala pakati pakudya.

Lipoic acid ndi mowa

Kugwiritsa ntchito bwino kwa mankhwalawa komanso kupewa matenda am'magazi kumakhudzidwa kwambiri ndi zakumwa zoledzeretsa, kuchepetsa mphamvu ya mankhwalawa. Mowa wa Ethyl umatha kudwalitsa thanzi la wodwala. Mankhwalawa, mowa uyenera kusiyidwa kwathunthu, ndipo anthu omwe ali ndi vuto la mankhwala osokoneza bongo ayenera kufunafuna thandizo kwa katswiri.

Zotsatira zoyipa

ALA imawonedwa ngati chinthu chotetezeka pamene mlingo womwe akuwonetsedwa wa chithandizo awonedwa. Zotsatira zoyipa za mankhwala sizimachitika kawirikawiri, zomwe zimawonetsedwa ndi izi:

• kusowa tulo
• nkhawa zochulukirapo
• kutopa
• matumbo
• zotupa
• redness pakhungu,
• nseru
• kupweteka m'mimba
• anaphylactic shock,
• dontho lakuthwa kwambiri la shuga,
• kuvutika kupuma.

Contraindication

Mankhwala okhala ndi biologic yogwira ntchito sayenera kumwedwa ndi odwala komanso oyembekezera, ana osaposa zaka zisanu ndi chimodzi, chifukwa palibe chidziwitso chokwanira pakalibe kuvulaza thupi lawo. Mutha kugwiritsa ntchito mankhwalawa pokhapokha mutakambirana ndi dokotala, makamaka anthu omwe ali ndi ma pathologies otsatirawa:

• odwala matenda ashuga
• anthu omwe ali ndi vuto la vitamini B,
• odwala ndi pathologies a mahomoni dongosolo ndi oncological matenda.

Mwa njira zambiri zochizira ndi kulimbitsa thupi, pharmacology imasiyanitsa mankhwala otsatirawa omwe ali ndi vuto lofanana ndi ALA, omwe amayenera kumwedwa atatha kufunsa dokotala:

• mapiritsi ndi msuzi wa aloe,
• Thupi lamtundu
• Apilak
• Spirulina algae mu mapiritsi, ufa, phala.

Mankhwala okhala ndi ALA angagulidwe ku malo ogulitsa mankhwala mumzinda, kapena, kuwongolera kuchokera pamakalabu, ogulidwa m'sitolo yapaintaneti. Mitengo ya mankhwala okhala ndi lipoic acid ndi awa:

Njira yamachitidwe

Alpha lipoic acid amasintha glucose kukhala mphamvu ndikuwukira ma radicals aulere, zomwe ndi zinthu zovulaza.

ALA imachulukitsa kagayidwe, imachepetsa zovuta zoyipa za makutidwe ndi okosijeni ndikuyambiranso mavitamini m'thupi, makamaka mavitamini C ndi E.

Kuphatikiza apo, alpha lipoic acid imagwira ntchito ngati synergist yokhala ndi mavitamini a B, omwe amafunikira kuti asinthe macronutrients onse kuchokera ku chakudya kukhala mphamvu.

Ngakhale alpha lipoic acid ndi mafuta acid, amathanso kusungunuka m'madzi. Zakudya zowonjezera zambiri zimasungunuka m'mafuta kapena madzi okha, koma osati awiri nthawi imodzi. Khalidweli limapangitsa kuti alpha lipoic acid ikhale yapadera komanso yothandiza kwambiri m'malo ambiri amthupi, zomwe zimachititsanso kuti ena azitcha "antioxidant universal."

Mukamamwa pakamwa, alpha lipoic acid amadziwidwa m'matumbo. Mosiyana ndi mafuta ena osungunuka, sizifunikira kuthira mafuta acids ndi chakudya. Zotsatira zake, mutha kumwa ALA mukasala kapena pamimba yopanda kanthu.

Ma antioxidant amphamvu

Zambiri mwa zothandizira za alpha lipoic acid zimachokera ku antioxidant. Ma antioxidants ndi mamolekyu omwe amalepheretsa kusintha kwaulere zomwe zimapangitsa kupsinjika kwa oxidative komanso maselo owonongeka. Pa oxidation, O2 imagawika maatomu awiri a oksijeni, iliyonse yomwe imakhala ndi elekitironi imodzi. Chifukwa ma elekitoni amakonda kukhala awiriawiri, "maulere aulere" awa - ma elekitron imodzi - amayang'ana ndikusankha ma elekitoni ena, mwakutero kuwononga maselo. Sikuti alpha lipoic acid imangoteteza ku ma radicals aulere, komanso amathandizanso kuwonjezera mphamvu ya ma antioxidants ena monga vitamini C ndi vitamini E.

Kuthamanga kwa mahomoni a chithokomiro

Kutsogolo kwa khosi kumakhala chithokomiro, chomwe ndi gawo lofunikira la endocrine system. Chimodzi mwazinthu zofunika kwambiri ndikupanga mahomoni omwe amawongolera kusasitsa, kukula ndi kagayidwe. Thanzi la chithokomiro likakhala pachiwopsezo, mahomoni amatuluka. Kafukufuku yemwe adachitika mu 2016 adawonetsa kuti alpha-lipoic acid ikamatengedwa ndi quercetin ndi resveratrol amathandizira kukulitsa kuchuluka kwachilengedwe kwa mahomoni a chithokomiro komanso kuchepa kwa thupi komwe kumachitika chifukwa cha kusalinganika kwa mahomoni.

Amathandizira Magazi a Magazi Oyenerera

Mafuta ochulukirapo a shuga, kapena shuga m'magazi, ndi omwe amachititsa kuti thupi lisakhalebe ndi insulin yayikulu, yomwe imathandiza shuga kulowa m'maselo anu. Popanda insulini, shuga amapanga ndipo amatha kudzetsa mavuto ambiri azaumoyo. Kafukufuku wa 2017 adawunika momwe alpha lipoic acid amadzimadzi am'magazi ndipo adapezeka kuti athandizira kupititsa patsogolo shuga wamagazi ndi kumva kwa insulini, zomwe zikuwonetsa kuti katundu wa ALA amapitilira kukhala antioxidant. .

Kuchulukitsa kumva kwa insulin

Mu odwala matenda ashuga, chifukwa cha kuchuluka kwa shuga m'magazi, kuwonongeka kwamitsempha yayikulu kumachitika - matenda a shuga. ALA imakulitsa chidwi cha insulin komanso imachepetsa chizindikiro cha izi mwa kukonza microcirculation. Malinga ndi kafukufuku wambiri, alpha lipoic acid amachepetsa zizindikiro za mitsempha yowonongeka (kupweteka, dzanzi la mikono ndi miyendo, kumva kutentha).

Phindu lalikulu la alpha-lipoic acid mu odwala matenda ashuga ndi chiopsezo chocheperako cha vuto la neuropathic lomwe limakhudza mtima, popeza pafupifupi 25% ya anthu omwe ali ndi matenda ashuga amakhala ndi mtima ndi mtima. Amadziwika ndi kusinthasintha kwa kuchuluka kwa mtima ndipo amalumikizidwa ndi chiwopsezo chakufa kwa anthu omwe ali ndi matenda ashuga. Kafukufuku akuwonetsa kuti kuwonjezera 600 mg patsiku la ALA kwa milungu itatu kumachepetsa kwambiri zizindikiro za matenda a shuga.

Imathandizira kukulitsa glutathione

Glutathione amatchedwa "antioxidant" wamkulu chifukwa ndi wofunikira popewa chitetezo, chitetezo chamthupi komanso kupewa matenda. Kafukufuku awonetsa kuti 300-1200 mg wa alpha lipoic acid amathandizira kukulitsa luso la glutathione kuwongolera kuyankha kwamthupi.

Kuphatikiza kwa ALA kumathandizira odwala omwe ali ndi immunodeficiency syndromes, kubwezeretsa kuchuluka kwa magazi ndi kuwongolera magwiridwe antchito a lymphocyte ku T-cell mitogens.

Zaumoyo

Mitsempha yamagazi imakhala ndi mbali imodzi ya maselo yotchedwa endothelium. Maselo a endothelial ali athanzi, amathandizira kupumula kwamitsempha yamagazi. The endothelial nembanemba atha kusokonezeka chifukwa cha matenda, zomwe zimabweretsa kuwonongeka mu mtima.

Ndi zaka, oxidative nkhawa imasokoneza thanzi la mtima. Kupsinjika kwa oxidative kumatha kuwononga minyewa ya m'mitsempha yamagazi ndikuwononga magazi. Ngakhale kuwonjezeka kwa ntchito ya mtima kumatha kudzetsa mavuto akulu azaumoyo, ma antioxidants amathandizira kulimbitsa thanzi la mtima. Alpha lipoic acid imalepheretsa kufa kwa cell ndikuthandizira kugwira ntchito kwa mtima.

Neuroprotection

Alpha lipoic acid samangolimbikitsa kukonzanso kwa ma neurons, komanso amathandizira kulimbana ndi zovuta za neurodegenerative. Zotsatira za kafukufuku wama makoswe pambuyo pa sitiroko zinawonetsa kuti ALA imathandiza pochiza matenda a ischemic chifukwa cha kuchepa kwa mitsempha komanso kubwezeretsa zinthu. Pakafukufuku wina, ALA inachepetsa kufa kwa 78% mpaka 26%, mkati mwa maola 24 atangoyamba kumene kumenyedwa.

Kupsinjika kwa oxidative kumatha kuwononga mitsempha m'maso ndikuyambitsa mavuto akuwona.Alpha lipoic acid wagwiritsidwa ntchito bwino kuthana ndi vuto lakumaso, kuphatikizira kuchepa kwa maseru, kuchepa kwa ma macular, kuwonongeka kwa retina, katangale, glaucoma, ndi matenda a Wilson.

Zotsatira zakuwonetsa kuti kugwiritsa ntchito alpha-lipoic acid kwanthawi yayitali kumakhala ndi phindu pa kukula kwa retinopathy. Pamene anthu akukalamba, masomphenya awo amakhala ochulukirachulukira, motero ndikofunikira kutsatira zakudya zokhala ndi michere, nthawi yayitali musanafike zakale, kupewa minofu ya maso kapena kuwonongeka kwamaso kumayambiriro.

Kuteteza minofu ku oxidative nkhawa

Kuchita masewera olimbitsa thupi ndi njira imodzi yabwino kwambiri yokwaniritsira kunenepa, kuthamanga kwa magazi ndikuwonjezera mphamvu zamagetsi. Kuchita masewera olimbitsa thupi kwambiri kungathandizire kuwonongeka kwa oxidative, komwe kumakhudza minofu ya minofu ndi ma cell.

Kupanikizika kwambiri kumathandizira kupweteketsa mtima komwe mumamva mutatha kuchita masewera olimbitsa thupi. Michere ya antioxidant monga alpha lipoic acid ingathandize kuchepetsa izi. Alpha lipoic acid amathandizira kumbuyo antioxidant chitetezo ndikuchepetsa lipid peroxidation.

Zimathandizira pa Ukalamba Wachisomo

Ndi ukalamba, kupsinjika kwa oxidative kumakhala ndi vuto maselo ndipo kumayambitsa kukalamba. Kafukufuku adaphunzira zomwe antioxidant zimatha alpha lipoic acid. Ena akuwonetsa kuti ALA imachepetsa kupsinjika kwa oxidative pamaselo a minofu. Kafukufuku wina wawonetsa kuti ALA ndi yofunikira popewa kudzikundikira kwachuma chochuluka mu cortex ya chithokomiro.

Amathandizira Thupi Labwino

Kudya zakudya zopukutidwa, kudya mwachangu, ndi zakudya zina zopanda thanzi kumabweretsa kunenepa kwambiri. Ndondomeko yotsimikizika yochepera thupi imaphatikizanso masewera olimbitsa thupi komanso kudya mokwanira. Komabe, michere monga alpha lipoic acid imatha kupititsa patsogolo mayendedwe amoyo wathanzi. Kafukufukuyu adawonetsa kuti odwala omwe adatenga ALA adakumana ndi kuchepa kwambiri kwa thupi poyerekeza ndi gulu la placebo.

Ubwino wina wa alpha lipoic acid

• Amachepetsa chiopsezo panthawi yomwe ali ndi pakati ndikuwongolera thanzi la mayi ndi mwana wosabadwayo.
• Amachepetsa mavuto a antipsychotic mankhwala.
• Kuchulukitsa kuchuluka kwa umuna, kutsata, ndikuyenda.
• Zimalepheretsa kuchepa kwa mafupa azimayi omwe ali ndi osteopenia ndi kuchepa kwa mafupa mu zotupa.
• Kuchulukitsa chiyembekezo chamoyo komanso kumenyana ndi khansa yam'mapapu ndi m'mawere.