Kugwiritsa ntchito mapiritsi a Actovegin

Odwala omwe ali ndi zotumphukira ndi chapakati mantha amathandizidwa ndi antioxidants, antiplatelet othandizira ndi mankhwala osokoneza bongo. Madokotala amatha kukupatsani mapiritsi a Actovegin a hypoxia, kutupa, ndi kuvulala komwe kumayambitsa kuperewera kwa mpweya m'maselo. Dziwani bwino ndi mtundu wa kumasulidwa, kapangidwe kake, mawonekedwe ogwiritsira ntchito, limagwirira ntchito ndi kufananiza kwa mankhwala.

Actovegin - zomwe zimathandiza

Actovegin imakhala ndi zovuta m'maselo a mitsempha. Mankhwala nthawi zambiri amagwiritsidwa ntchito pochiza matenda omwe amakhudzana ndi mitsempha. Mankhwalawa ali ndi zinthu zotsatirazi:

zimawonjezera kukhathamira kwa glucose,
Amathandiza kuti mpweya uzitenga michere,
imapangitsa kagayidwe (cell metabolism),
amalimbikitsa kugwiritsidwa ntchito kwa oksijeni, mayendedwe a shuga m'mizimba ya thupi.

Munthu aliyense ali ndi malire pazomwe zimachitika mu metabolism ya mphamvu (minofu siziperekedwa ndi mpweya, kukhudzika kwa okosijeni kumayipa, hypoxia imachitika), mosinthanitsa, zimawonjezera mphamvu yamagetsi (kusinthika kwa minofu). Mankhwalawa amathandizira kukonza kuyamwa kwa zinthu ndi thupi, amathandizanso pamagetsi. Njira yothetsera vutoli ndi yothandiza kwambiri pakamavuto azungu.

Mlingo

Jekeseni 40 mg / ml - 2 ml, 5 ml

ntchito yogwira - kufooketsa hemoderivative wa magazi a ng'ombe (malinga ndi nkhani youma) * 40.0 mg.

obwera: madzi a jakisoni

* ili ndi pafupifupi 26.8 mg wa sodium chloride

Transparent, chikasu njuchi.

Pharmacodynamics ndi pharmacokinetics

Actovegin ndi antihypoxant. Imapezeka pogwiritsa ntchito dialysis ndi ultrafiltration. Mankhwala ali ndi phindu pa kayendedwe ndi kagwiritsidwe ntchito ka glucose, limakhazikitsa ma membrane a plasma a maselo pa ischemia kudzera pakumwa mpweya. Chombochi chimayamba kugwira ntchito kwa theka la ola itatha kuyamwa. Kutheka kwakukulu kumatha kuchitika pambuyo pa maola atatu.

Pharmacokinetics sichinaphunziridwe bwino, koma zigawo zonse za mankhwalawa zilipo m'thupi momwe zimakhalira. Kutsika kwa mankhwalawa chifukwa cha mankhwala sanapezeke mwa anthu omwe ali ndi vuto la hepatic kapena aimpso, kusintha kwa kagayidwe kogwirizana ndi ukalamba. Zokhudza ana akhanda sizinaphunziridwe kwathunthu, makamaka poganizira momwe zimapangidwira, motero tikulimbikitsidwa kuti mugwiritse ntchito mosamala komanso pokhapokha ngati madokotala akupezekapo.

Actovegin - zofunikira pakugwiritsa ntchito

Chifukwa cha kulowetsedwa kwa mankhwalawa, kuchuluka kwa hemoglobin, DNA ndi hydroxyproline kumawonjezeka. Malinga ndi kufutukula kwa malangizowo, mapiritsiwa amangogwiritsidwa ntchito ngati mankhwala othandiza a:

mikwingwirima ya ischemic ndi hemorrhagic,
kuvulala kwamitsempha yamaubongo komanso encephalopathy,
matenda oyenda m'magazi,
kusokoneza venous.

Mu shuga mellitus, mankhwalawa amachepetsa ululu kapena kuwotcha m'munsi, amagwiritsidwa ntchito kuwotchera, kupatula digiri ya 4, kuchiritsa mabala ndi zotupa zina pakhungu. Kuphatikiza apo, chida chimathandizira kukonza:

kagayidwe
magazi obwera ndi ubongo,
kufalikira kwamwazi.

Mankhwala

Pharmacokinetics

Ndizosatheka kuphunzira za pharmacokinetic makhalidwe (mayamwidwe, magawidwe, ma excretion) a Actovegin®, popeza imangokhala ndi zofunikira za thupi zomwe zimapezeka mthupi.

Actovegin ® imakhala ndi antihypoxic athari, yomwe imayamba kuwoneka posachedwa kwambiri mphindi 30 pambuyo pa utsogoleri waboma ndikufika pazowonjezera pambuyo pa maola atatu (maola 2-6).

Mankhwala

Actovegin® antihypoxant. Actovegin ® ndi hemoderivative, yomwe imapezeka ndi dialysis ndi ultrafiltration (ikamapangidwa ndi kulemera kwa maselo osakwana 5000 daltons). Actovegin ® imapangitsa kulimbitsa mphamvu kwa organic mu cell. Zochita za Actovegin® zimatsimikiziridwa poyesa kuyamwa komanso kugwiritsa ntchito shuga komanso mpweya wabwino. Zotsatira ziwirizi zimayenderana, ndipo zimatsogolera pakuwonjezeka kwa kupanga kwa ATP, mwakutero kupereka mphamvu yochulukirapo ku cell. Pansi pazomwe zimachepetsa magwiridwe antchito a mphamvu kagayidwe (hypoxia, kusowa kwa gawo lapansi), komanso kuwonjezereka kwa mphamvu (kuchiritsa, kusinthanso) Actovegin ® imalimbikitsa mphamvu zama processor metabolism ndi anabolism. Yachiwiri zotsatira kuchuluka magazi.

Zotsatira za Actovegin ® pa mayamwidwe ndi kugwiritsa ntchito mpweya, komanso ntchito yofanana ndi insulini ndi kukondoweza kwa mayendedwe a glucose ndi oxidation, ndizofunikira pa chithandizo cha matenda ashuga a polyneuropathy (DPN).

Odwala omwe ali ndi matenda a shuga a mellitus ndi matenda ashuga polyneuropathy Actovegin ® amachepetsa kwambiri zizindikiro za polyneuropathy (kupweteka kwa msungu, kumva kutentha, parasthesia, dzanzi m'magawo otsika). Mokulira, kusokonezeka kwa chidwi kumachepetsedwa, ndipo thanzi la odwala limadranso bwino.

Mlingo ndi makonzedwe

Actovegin ®, jekeseni, amagwiritsidwa ntchito intramuscularly, kudzera m'mitsempha (kuphatikizapo mawonekedwe a infusions) kapena kudzera m'mitsempha.

Malangizo ogwiritsira ntchito ma ampoules omwe ali ndi malo amodzi akupumira:

tengani zochulukira kuti pamwamba pomwe pamakhala chizindikirocho. Kukoka pang'ono ndi chala ndikugwedeza zokwanira, lolani kuti yankho lake lithe kuchoka kumapeto kwa phokoso. Dulani pamwambapa mwa kukanikiza chizindikiro.

a) Mulingo wovomerezeka:

Kutengera ndi kuopsa kwa chithunzi chachipatalachi, mlingo woyambirira ndi 10-20 ml kudzera m'mitsempha kapena intraarter, ndiye 5 ml iv kapena pang'onopang'ono IM tsiku lililonse kapena kangapo pa sabata.

Ikagwiritsidwa ntchito ngati infusions, 10-50 ml imalowetsedwa mu 200-300 ml ya isotonic sodium chloride solution kapena 5% dextrose solution (masanjidwe oyambira), kuchuluka kwa jakisoni: pafupifupi 2 ml / min.

b) Mlingo kutengera ziwonetsero:

Matenda amisempha ndi mtima: kuyambira 5 mpaka 25 ml (200-1000 mg patsiku) kudzera tsiku lililonse kwa masabata awiri, kenako ndikusintha kwa mawonekedwe a piritsi.

Matenda ozungulira komanso azakudya monga ischemic stroke: 20-50 ml (800 - 2000 mg) mu 200-300 ml ya 0,9% ya sodium kolorayidi kapena 5% shuga, mumatsika mkati tsiku lililonse kwa sabata 1, ndiye 10-20 ml (400 - 800 mg) kudzera m'mitsempha kukapanda kuleka - masabata awiri ndikusintha kwa mawonekedwe a piritsi.

Zowonongeka za mtima (zotupa ndi venous) zamatsenga ndi zotsatira zawo: 20-30 ml (800 - 1000 mg) ya mankhwala mu 200 ml ya 0,9% sodium kolorayidi kapena 5% shuga, kudzera m'mitsempha kapena mtsempha tsiku lililonse, kutalika kwa mankhwalawa ndi milungu 4.

Dongosolo la matenda ashuga: 50 ml (2000 mg) patsiku kudzera m'mitseko kwa masabata atatu ndikusintha kwa mapiritsi a mapiritsi - 2-3 mapiritsi 3 katatu patsiku kwa miyezi yosachepera 4-5.

Zilonda zoyipa za m'munsi: 10 ml (400 mg) kudzera m'mitsempha kapena 5 ml tsiku ndi tsiku kapena katatu pa sabata, kutengera njira yochizira

Kutalika kwa nthawi ya mankhwalawa kumatsimikiziridwa payekhapokha malinga ndi mawonekedwe ndi kuuma kwa matendawa.

Malangizo apadera

Intramuscularly, ndikofunikira kupaka pang'onopang'ono osaposa 5 ml, chifukwa yankho lake ndi hypertonic.

Poganizira za kuthekera kwa ma anaphylactic, tikulimbikitsidwa kuti jakisoni wachiwiri (2 ml intramuscularly) akaperekedwe asanayambe chithandizo.

Kugwiritsa ntchito Actovegin® kuyenera kuchitika moyang'aniridwa ndi achipatala, ndi kuthekera koyenera kwa mankhwalawa.

Pogwiritsa ntchito kulowetsedwa, Actovegin®, jekeseni, amatha kuwonjezeredwa ndi isotonic sodium chloride solution kapena 5% shuga. Zoyeserera ziyenera kuwonedwa, popeza Actovegin ® ya jakisoni sikhala ndi mankhwala osungira.

Kuchokera pamalingaliro achilengedwe, ma ampoules otseguka ndi mayankho okonzekera ayenera kugwiritsidwa ntchito nthawi yomweyo. Mayankho omwe sanagwiritsidwe ntchito ayenera kutayidwa.

Ponena za kusakaniza njira ya Actovegin ® ndi njira zina zothetsera jakisoni kapena kulowetsedwa, kusayenerana kwaumoyo, komanso mgwirizano pakati pazogwira ntchito, sizingasiyidwe kwina, ngakhale yankho likhale lowonekera bwino. Pachifukwa ichi, yankho la Actovegin® siliyenera kuperekedwa posakaniza ndi mankhwala ena, kupatula omwe atchulidwa mu malangizowo.

Njira yothetsera jakisoni imakhala ndi kuwala kwa chikasu, kuchuluka kwake komwe kumadalira chiwerengero cha batch ndi zinthu zomwe zimapezeka, komabe, mtundu wa yankho sakukhudza kugwiriridwa ndi mankhwalawa.

Osagwiritsa ntchito yankho la opaque kapena yankho lomwe lili ndi tinthu tating'onoting'ono!

Gwiritsani ntchito mosamala mu hyperchloremia, hypernatremia.

Palibe deta yomwe ilipo ndipo kugwiritsa ntchito sikololedwa.

Gwiritsani ntchito pa nthawi yoyembekezera

Kugwiritsa ntchito Actovegin ® ndikololedwa ngati chithandizo chamankhwala chikuyembekezeka kupitilira chiwopsezo cha mwana wosabadwayo.

Gwiritsani ntchito pokonza mkaka

Mukamagwiritsa ntchito mankhwalawa m'thupi la munthu, palibe zotsatirapo zoyipa zomwe zimabwera chifukwa cha mayi kapena mwana. Actovegin® iyenera kugwiritsidwa ntchito panthawi yokhayo pokhapokha ngati chithandizocho chikuyembekezeredwa kuposa chiwopsezo cha mwana.

Zomwe zimachitika chifukwa cha mankhwalawa amatha kuyendetsa galimoto kapena njira zoopsa

Palibe zotsatira zazing'ono zomwe zingatheke.

Bongo

Palibe deta pa kuthekera kwa bongo wa Actovegin®. Kutengera ndi data ya pharmacological, palibe zovuta zina zomwe zimayembekezera.

Kutulutsa Fomundi kunyamula

Jekeseni 40 mg / ml.

2 ndi 5 ml ya mankhwalawa m'magalasi osayera amtundu (mtundu I, Heb. Pharm.) Ndi malo osweka. Ma ampoules asanu pa pulasitiki yonyamula matuza. 1 kapena 5 matuza okhala ndi malangizo ogwiritsira ntchito aikidwa pabokosi lamakatoni. Zolemba zoteteza kuzungulira zowonekera ndi zolemba za holographic ndi chiwongolero choyamba chotsegulidwa zimapakidwa pa paketi.

Kwa mamililita 2 ndi 5 ml, chizindikirocho chimayikidwa pakamwa pagalasi kapena palemba omwe amatsatira.

Wogwirizira Sitifiketi Yoyang'anira

LLC Takeda Mankhwala, Russia

Packer ndikupereka mawonekedwe oyang'anira

LLC Takeda Mankhwala, Russia

Adilesi ya bungwe lolandila madandaulo kuchokera kwa ogula pa mtundu wa zinthu (katundu) mdera la Republic of Kazakhstan:

Ofesi yoyimira a Takeda Osteuropa Holding GmbH (Austria) ku Kazakhstan

Kutulutsa mawonekedwe ndi kapangidwe kake

Yogwira pophika mankhwala amathetsedwa hemoderivative kwa magazi a ng'ombe pa mlingo wa 40 mg wa millilita wa yankho. Ma jakisoni mawonekedwe a Actovegin amapangidwa mu ma ampoules osiyanasiyana komanso osiyanasiyana:

400 mg yankho, mu phukusi la ma ampoules 5 a 10 ml iliyonse,
200 mg yankho, mu phukusi la ma ampoules 5 a 5 ml aliyense,
80 mg yankho, mu phukusi la ma 25 ampoules a 2 ml.

Ampoules ali mumtsuko wapulasitiki. Phukusi lachiwiri limapangidwa ndi makatoni. Ili ndi chidziwitso pazinthu zopanga komanso nthawi yovomerezeka. Mkati mwa chidebe chamakatoni, kuwonjezera pa chidebe ndi ma ampoules, mumaphunzitsidwanso mwatsatanetsatane. Mtundu wa yankho ndi wachikasu ndi mithunzi yosiyanasiyana, kutengera kutulutsidwa. Kukula kwamtundu sikukhudza chidwi cha mankhwalawo komanso kugwira ntchito kwake.

Zizindikiro zogwiritsidwa ntchito

Actovegin imatha kutumizidwa pamikhalidwe yambiri yopweteka. Kugwiritsidwa ntchito kwake kuli koyenera ku matenda otere:

mankhwala a hemorrhagic sitiroko ndi zotsalira pambuyo pake,
encephalopathies a magawo osiyanasiyana,
zolephera zomwe zimadziwika mu ntchito ya venous, capteral or orterial magazi,
ischemic stroke,
kuvulala kwamatumbo osiyanasiyana,
angiopathies, makamaka ochokera kwa odwala matenda ashuga,
radiation, kutentha, dzuwa, mankhwala awotcha mpaka madigiri 3,
diabetic zotumphukira polyneuropathies,
kuwonongeka kwa trophic
mabala azitsulo zosiyanasiyana zomwe ndizovuta kuchiza,
zotupa pakhungu,
zironda zamphamvu zomwe zimachitika
kuwonongeka kwa mucous nembanemba ndi khungu, kuyambitsa kuwonongeka kwa radiation,
radiation neuropathies.

Mlingo ndi makonzedwe

Panjira yolowera pakayendetsedwe ka malo, Actovegin ikhoza kutumizidwa kukapanda kuleka kapena kuwongolera. Asanayambike mitsempha, ndikofunikira kupukusira mankhwalawa mu 0.9% yac sodium chloride solution kapena mu 5% shuga. Mlingo womaliza wovomerezeka wa Actovegin ndi wofika 2000 mg wa chinthu chouma pa 250 ml ya yankho.

Pa intraarterial, Actovegin iyenera kugwiritsidwa ntchito pa mlingo wa 5 mpaka 20 ml patsiku.

Mlingo pamene kutumikiridwa intramuscularly sangadutse 5 ml maola 24. Pankhaniyi, mawu oyamba amapita pang'onopang'ono.

Pambuyo pofufuza momwe wodwalayo alili, mlingo wofunikira umasankhidwa. Mlingo woyenera kumayambiriro kwa mankhwalawa ndi 5 - 10 ml iv kapena iv. M'masiku otsatirawo, 5 ml kudzera m'mitsempha kapena m'mitsempha tsiku lililonse kapena kangapo pa masiku 7. Jakisoni wam'mimba amachedwa.

Wodwala kwambiri, ndikulimbikitsidwa kuti Actovegin athandizidwe mwachangu mu 20 mpaka 50 ml patsiku kwa masiku angapo mpaka mkhalidwe utasintha.

Ngati mukuchulukirachulukira kosakhazikika kwamatenda osiyanasiyana komanso matenda okhala ndi zovuta, muyenera kupatsa Actovegin i / m kapena iv mu mlingo wa 5 mpaka 20 ml pakadutsa masiku 14 mpaka 17. Kusankhidwa kwa Mlingo kumachitika kokha ndi dokotala!

Ngati ndi kotheka, njira ya mankhwala, mankhwalawa atha kutumikiridwa mu 2 mpaka 5 ml kwa maola 24 ndi njira yodziwikitsira minofu kapena mtsempha kwa milungu 4 mpaka 6.

Pafupipafupi kayendetsedwe kazikhala kuyambira 1 mpaka katatu. Kuchuluka kumeneku kumasiyanasiyana malinga ndi momwe wodwalayo alili.

Pochiza odwala matenda ashuga polyneuropathy, ndi bwino kuyamba kugwiritsa ntchito Actovegin ndi mtsempha wamkati. Mlingo mu nkhani iyi ndi 2 ga patsiku, njira ya mankhwala ndi masiku 21. M'tsogolomu, ndikofunikira kusinthira ku fomu ya piritsi limodzi ndi mapiritsi a 2 mpaka 3 a maola 24. Njira yoyendetsera motere ndi pafupifupi miyezi 4.

Zotsatira zoyipa

Malinga ndi kafukufuku wambiri, jakisoni a Actovegin amaloledwa bwino ndi odwala. Kuchita kwa anaphylactic, mawonetseredwe a ziwonetsero, ndi kugundana kwa anaphylactic sizingaoneke. Nthawi zina zovuta zotere zimatha kuoneka:

Zowawa pakhungu la jakisoni kapena khungu rede,
mutu. Nthawi zina amatha kutsagana ndi chizungulire, kufooka kwathunthu m'thupi, kuoneka ngati kunjenjemera.
kulephera kudziwa
mawonetseredwe a dyspeptic: kusanza, kutsegula m'mimba, kupweteka kwam'mimba, nseru,
tachycardia
khungu limayamba mwadzidzidzi,
zotupa pa thupi (urticaria), kuyabwa kwa khungu, kutupa, angioedema,
kupweteka kwa kupweteka kapena kupweteka kwa minofu,
acrocyanosis,
kuchepa, kapena, kuchuluka kwa kuthamanga kwa magazi,
kupweteka m'dera lumbar,
paresthesia
dziko lokondwa
kutsutsika
mavuto kupuma
kumeza movutikira,
zilonda zapakhosi,
kumverera kwa kupweteka pachifuwa,
kupweteka kwa mtima
kuchuluka kwa kutentha,
kutuluka thukuta kwambiri.

Mapiritsi a Actovegin - malangizo ogwiritsira ntchito

Actovegin amatengedwa pakamwa. Wodwala ayenera kumwa mapiritsi 1-2 katatu patsiku.Sakufunikira kutafuna, mutha kumwa ndi madzi kapena madzi (madzi aliwonse). Ndi bwino kugwiritsa ntchito mankhwalawa musanadye. Njira ya mankhwala ndi masiku 30-45. Odwala odwala matenda ashuga polyneuropathy, mapiritsi a 2-3 amapatsidwa pakamwa katatu kapena tsiku. Njira yothira mankhwalawa ndi miyezi 4-5. Kutalika kwa kuvomerezedwa kumatsimikiziridwa ndi katswiri wa mitsempha.

Migwirizano yogulitsa ndikusunga

Actovegin ya mankhwala ingagulidwe kokha ndi mankhwala. Pewani mankhwalawo patali ndi ana ndipo mutetezedwe pakuwala. Kutentha m'chipindacho sikuyenera kupitirira 25 degrees. Chidacho chili ndi moyo wa alumali wazaka zitatu.

Mankhwala ali ndi mitundu ingapo. Komabe, si onse omwe ali ndi vuto lofanana mthupi, ndipo kapangidwe kake sikogwirizana ndi ma amino acid omwe amapezeka m'thupi la munthu. Mwa ma analogi omwe aperekedwa, palibe mankhwala omwe angagwiritsidwe ntchito kwa mwana. Mndandandawu umaphatikizapo Curantil, Dipyridamole ndi Vero-Trimetazidine:

Curantyl akuwonetsedwa kwa thrombosis, kupewa ndi kuchiza kufalikira kwa matenda a m'magazi, kupewa kuperewera kwa m'mimba, myocardial hypertrophy. Contraindicated ngati wapezeka: pachimake myocardial infarction, angina pectoris, kwambiri arrhythmia, chapamimba chilonda, chiwindi kulephera.
Dipyridamole amagwiritsidwa ntchito poletsa postoperative thrombosis, myocardial infarction, cerebrovascular ngozi, ndi zovuta za metabolic. Zowopsa za angina pectoris, coronary artery atherosulinosis, kugwa.
Vero-trimetazidine amagwiritsidwa ntchito ngati angina pectoris. Kulera, aliyense tsankho kwa zigawo zikuluzikulu za mankhwala.

Mtengo wa mapiritsi a Actovegin

Analog of Actovegin kapena mankhwalawo pawokha atha kugulidwa ku malo ogulitsa mankhwala kapena pa intaneti. Fotokozerani mtengo wake, kenako ndikulamula ndikutumiza ku Moscow kapena dera la Moscow. Mutha kusunga bajeti mwakuwunika mitengo ya mankhwala m'dera lomwe mwasankhalo. Pansipa pali tebulo lamtengo wamankhwala omwe amapezeka muma fakitoreya osiyanasiyana pa intaneti:

Kristina, wazaka 28 Mayi anga ali ndi vuto la kusowa kwa venous. Kuti magazi aziyenda bwino, ndinagula Actovegin. Malinga ndi adotolo, mukamamwa mankhwalawo, magazi amayendetsedwa mwachangu, njira zobwezeretsanso minofu zimasintha. Amayi anakhutitsidwa, nabwerera m'moyo wawo wakale wogwira ntchito. Ndikupangira izi kwa aliyense.

Phillip, wazaka 43. Ndine dokotala wazaka khumi ndi zisanu. Kupititsa patsogolo thanzi la odwala omwe ali ndi matenda aubongo, ndikulimbikitsa Actovegin. Mankhwalawa amafulumizitsa njira zamagwiritsidwe ntchito ka oxygen, amathandizira kuti wodwalayo ayambe kuchira mwachangu. Malinga ndi odwala, mankhwalawa amachitapo kanthu mwachangu.

Alevtina, wazaka 29 Bambo anga anapezeka ndi matenda opha ziwalo ndi glaucoma. Kuyambira pamenepo akunama. Pakuchiritsa zilonda zipsinjo, tinayamba kugwiritsa ntchito Actovegin. Malinga ndi ndemanga ndi zotsatira, titha kunena kuti mankhwalawa ndi othandiza. Madokotala amalankhula zabwino za mankhwalawa, chifukwa amathandizira kuyambitsa kugwiritsa ntchito mpweya ndi maselo. Mtengo unakondwera.