Gliclazide Canon: malangizo a mapiritsi

Gliclazide Canon: malangizo ogwiritsira ntchito ndi kuwunikira

Dzina lachi Latin: Gliclazide Canon

Code ya ATX: A10BB09

Chithandizo chogwira: Gliclazide (Gliclazide)

Wopanga: Kupanga kwa Kanonfarma, CJSC (Russia)

Sinthani mafotokozedwe ndi chithunzi: 07/05/2019

Mitengo muma pharmacies: kuchokera ku ma ruble a 105.

Glyclazide Canon ndi mankhwala amkamwa a hypoglycemic a gulu lachiwiri la sulfonylurea.

Kutulutsa mawonekedwe ndi kapangidwe kake

Fomu ya Mlingo - mapiritsi olimbikitsidwa: pafupifupi oyera kapena oyera, kuyenda pang'ono kwa mawonekedwe, kuzungulira biconvex, 60 mg iliyonse ndi mzere wogawa (Gliclazide Canon 30 mg: ma 10 ma PC. Mumapaketi a blister, mu 3 kapena 6 mapaketi a carton) , Ma pc 30. mumapaketi a blister, pamakatoni okhala ndi 1 kapena 2 mapaketi, Canon Glyclazide 60 mg: ma PC 10. M'matumba a chithuza, m'matumba a makatoni a 3 kapena 6, ma pc 15. makatoni okhala 2 kapena 4 mapaketi, mkati Paketi iliyonse ilinso ndi malangizo ogwiritsira ntchito Glyclazide Canon).

Piritsi limodzi:

• yogwira mankhwala: gliclazide - 30 kapena 60 mg,
• othandizira zigawo (30/60 mg): magnesium stearate - 1.8 / 3.6 mg, ma cellcrystalline cellulose - 81.1 / 102.2 mg, mafuta a masamba a hydrogenated - 3.6 / 7.2 mg, hypromellose - 50 / 100 mg, colloidal silicon dioxide - 3.5 / 7 mg, mannitol - 10/80 mg.

Mankhwala

Glyclazide - chinthu chogwira ntchito cha Glyclazide Canon, ndimachokera ku sulfonylurea ndipo ndi othandizira pakamwa. Amasiyana ndi mankhwala omwewo pamaso pa mphete ya N-heterocyclic yokhala ndi chomangira cha endocyclic.

Gliclazide imathandizira kuchepetsa kuchuluka kwa shuga m'magazi, omwe amaperekedwa ndikulimbikitsa kubisala kwa insulin ndi maselo a beta a isanger a Langerhans. Kutalika kwa zotsatira zakuchulukitsa kwa postprandial insulin ndi C-peptide kumapitiliza pambuyo zaka 2 za mankhwala. Thupi, kuwonjezera pa kukhudza kagayidwe kazachilengedwe, lili ndi mphamvu ya hemovascular and antioxidant.

Mukamagwiritsa ntchito Glyclazide Canon pochizira matenda amishuga a m'matenda a 2, mankhwalawa amapezeka mwachangu chifukwa cha kuchuluka kwa shuga komanso kuwonjezeka kwa gawo lachiwiri la insulin. Chifukwa cha kukondoweza, komwe kumachitika chifukwa cha kuyambitsa shuga kapena kudya, pali kuwonjezeka kwakukulu kwa katemera wa insulin.

Kuchita kwa gliclazide cholinga chake ndikuchepetsa chiopsezo cha chotupa chamagazi chotupa, chomwe chimachitika chifukwa cha zomwe zimapangidwa ndimatenda a shuga. Izi zikuphatikiza: zoletsa zochepa za kuphatikiza kwa kupatsidwa zinthu za m'magazi ndi kuphatikiza, kuchepa kwa kuchuluka kwa ma cell kutsegula₂beta-thromboglobulin). Kuphatikiza apo, Gliclazide Canon imakhudzanso kubwezeretsanso kwa ntchito ya fibrinolytic ya vasotor endothelium komanso kuwonjezeka kwa kulimbikitsa kwa minofu ya plasminogen activator.

Poyerekeza ndi chiwongolero cha glycemic chokhazikika (kutengera zotsatira za kafukufuku wa ADVANCE), chifukwa cha kuwongolera kwa glycemic kutengera nthawi yayitali yotulutsidwa kwa glycazide tiba, mtengo wa HbAlc (glycosylated hemoglobin)

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa amapangidwira zochizira matenda osagwirizana ndi insulin (mtundu 2), ngati kukonza zakudya, kunenepa komanso kuchita zolimbitsa thupi sikubweretsa zotsatira. Kuphatikiza apo, mankhwalawa ndi oyenera kupewetsa zovuta za matenda a shuga 2 (ma micro- and macro-vascular pathologies), mankhwalawa a matenda aposachedwa (momwe amangoyerekezera, momwe mulibe matchulidwe azachipatala a matenda ashuga), onenepa kwambiri.

Kupanga ndi mafomu omasulira

Zotsatirazi ndizophatikizidwa ndimankhwala:

• Yogwira: gliclazide 30 kapena 60 mg.
• Zothandiza: hydroxypropyl methylcellulose, colloidal silicon dioxide, mannitol, E572 (magnesium stearate), mafuta a masamba a hydrogenated, cellcrystalline cellulose.

Gliclazide canon imapangidwira pakamwa. Fomu ya Mlingo: Mapiritsi othandizira omasulira. Wopanga amapereka mitundu ingapo yosiyanasiyana: 30 ndi 60 mg. Mapiritsiwo ndi ozungulira, opendekera kuchokera mbali ziwiri, oyera (mtundu wa miyala ya mendulo, kukhuthala), osanunkhira.

Kuchiritsa katundu

Limagwirira ntchito limalumikizidwa ndi mphamvu ya sulfonylurea zotumphukira zolandilira mu pancreatic β-cell. Zotsatira zamachitidwe omwe amachitika pamaselo a m'manja, njira za KatiF + zimatsekedwa ndipo ziwalo za β-cell zimasungunuka. Chifukwa cha kuchepa kwa ma membala am'mimba, ma njira a Ca + amatsegulidwa, ma ion a calcium amalowa mu β-cell. Insulin imatulutsidwa ndikutulutsidwa m'magazi.

Nthawi yomweyo, mankhwalawa amatsitsa pang'onopang'ono maselo a kapamba, nkumayambitsa ziwopsezo, matenda ammimba, zimawonjezera mwayi wa hypoglycemia, etc. Amagwira mpaka ntchito ya insulini yopanga inshuwaransi itatha. Ndiye chifukwa chake kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, mphamvu zake zoyambirira pakhungu la insulin zimachepa. Komabe, patapita kanthawi kovomereza, zimachitika m'maselo a β-cell.

Gliclazide canon imathamanga mwachangu komanso kwathunthu kuchokera kumimba. Mukatha kudya, shuga amadzuka, ndiye kuti gawo lalikulu la insulin yolimbikitsidwa limachitika nthawi imeneyi. Kugwiritsa ntchito mankhwalawa ndi chakudya kungachepetse kuyamwa. Matenda oopsa a hyperglycemia amathanso kuchepetsa mayamwidwe ndipo zimachitika chifukwa chakuti matenda am'mimba amaphatikizidwa ndi kuchepa kwa ntchito ya m'mimba.

Mankhwala amayamba pakatha maola awiri ndi atatu atapita. Pazitali kwambiri pazogwira ntchito m'magazi zimawonedwa pambuyo pa maola 7-10. Kutalika kwa kuchitapo kanthu - tsiku limodzi. Amayikamo mkodzo, komanso kudzera m'mimba.

Njira yogwiritsira ntchito

Mtengo wapakati wa mankhwalawa ndi 60 mg - 150 rubles. 30 mg - 110 rubles.

Mankhwalawa ndi oyenera okha akuluakulu. Mlingo patsiku - 30-120 mg. Mlingo wofanana uyenera kufotokozedwa ndi dokotala yemwe akuganizira za momwe matendawo alili, Zizindikiro zake, shuga osala komanso maola awiri atatha kudya, m'badwo wa wodwalayo komanso momwe munthu angachitire chithandizo. Monga lamulo, mulingo woyambirira wa mankhwalawa siwoposa 80 mg, komanso kupewa kapena kuthandizira kukonza - 30-60 mg.

Ngati zikuwululidwa kuti mulingo wa mankhwalawo sugwira ntchito mokwanira, ndiye kuti umachulukitsidwa pang'ono ndi pang'ono. Kuphatikiza apo, kusintha kulikonse kwamankhwala azamankhwala sikuyenera kuchitika pasanathe milungu iwiri kuchokera pa chiyambi cha chithandizo. Ngati mulingo umodzi kapena zingapo mwakusowa, ndizosatheka kuwonjezera kuchuluka kwa mlingo wotsatira.

Ndi bwino kumwa tsiku lililonse 1 pakumeza piritsi lonse. Popewa kusakanikirana ndi mankhwala ndi chakudya, ndibwino kugwiritsa ntchito mankhwalawa theka la ola musanadye.

Pa nthawi yoyembekezera komanso yoyamwitsa

Zomwe zimachitika chifukwa cha mankhwalawa pa nthawi yoyembekezera komanso mwana wosabadwa sizimamveka bwino. Chifukwa chake, malangizo ogwiritsira ntchito amaletsa kugwiritsa ntchito mankhwalawa panthawi yakubala kwa mwana ndi HB.

Contraindication ndi Kusamala

Kuvomerezedwa kumatsutsana pamaso pa zinthu zotsatirazi:

• shuga wodalira insulin (mtundu 1),
• matenda ashuga ketoacidosis, chikomokere,
• chiwindi chachikulu, matenda a impso,
• nthawi ya bere, GV,
• zaka za ana
• Hypersensitivity kwa zinthu zikuchokera mankhwala.

Hypoglycemia imayendera limodzi ndi kuchepa kwa kugundika, chizungulire, kukhumudwa kwa malo, ndi zizindikiro zina. Wodwala matenda ashuga ayenera kudziwa momwe matendawa angathere komanso kusamala mukamachita zinthu zomwe zimafunikira kuchitapo kanthu mwachidule (mwachitsanzo, kuyendetsa galimoto).

Kuchita mankhwala osokoneza bongo

Zotsatira zamankhwala zimatha kupitilizidwa ndi mankhwala ena, zomwe zimawonjezera mwayi wokhala ndi hypoglycemia. Glyclazide Canon waphatikizidwa ndi Miconazole. Sitikulimbikitsidwa kuphatikiza kudya ndi phenylbutazone, ethanol.

Kuphatikizidwa kwa mankhwalawo ndi othandizira ena a hypoglycemic (insulin, acarbose), beta-blockers, ACE inhibitors, kukonzekera kwa calcium, β-blockers amafunika kusamala, chifukwa timapitiriza zotsatira za hypoglycemic.

Mankhwala otsatirawa amachepetsa mphamvu ya mankhwala:

• Danazole - ali ndi matenda ashuga,
• Chlorpromazine - kumawonjezera shuga m'magazi, kumachepetsa katulutsidwe ka insulin.

Zotsatira zoyipa ndi bongo

Gliclazide canon imalekeredwa bwino ndi odwala. Mankhwalawa ndiwogwira ntchito kuposa mbadwo woyamba wa sulfonylureas. Izi zimathandiza kugwiritsidwa ntchito kwa mankhwala otsika a mankhwalawa, omwe amachepetsa mwayi wosagwiritsidwa ntchito poyambira.

Koma mukagwiritsira ntchito nthawi yayitali, mavuto amabwera. Chimodzi mwazomwe zimachitika ndizovuta za hypoglycemia, makamaka kwa anthu okulirapo zaka 50, omwe ali ndi vuto lina:

• Munthawi yomweyo mankhwala angapo.
• Kuchepetsa thupi.
• Osamadya mokwanira.
• Zakumwa zoledzeretsa.
• Kuphwanya impso, chiwindi, ndi zina zambiri.

Komanso, motsutsana ndi maziko a kudya pafupipafupi, odwala nthawi zambiri amakhala ndi chidwi chambiri, chomwe chimatsogolera ku magulu owonjezera. Pofuna kupewa kulemera, ndikofunikira kuti muzitsatira zakudya zama hypocaloric.

Zina zoyipa zotenga zimaphatikizanso:

• Mavuto Am'mimba: kusanza, kutsegula m'mimba, kusokonezeka m'mimba / zilonda, kusanza.
• Ziwengo (zotupa, kuyabwa kwa khungu).
• CNS: kusakwiya, kusowa tulo, kukhumudwa, kupuma mosasunthika, kulephera kukhazikika, kusokonezeka, kutsika, nkhawa, nkhawa, mantha.
• Zotengera, mtima: palpitations, kuchuluka magazi, magazi.
• Chiwindi, matenda a biliary: cholestatic jaundice, hepatitis.
• Zowonongeka, khungu la khungu.

Zotsatira zoyipa izi ndizosowa kwenikweni, mu 1-2% ya odwala. Pakachitika izi pamwambapa, oyang'anira akuyenera kusiya.

Tikulimbikitsidwa kupewa kwambiri mlingo wa mankhwalawa, chifukwa chiopsezo cha hypoglycemia chimawonjezeka, ndipo kusinthasintha kosalekeza kwa β-cell kumawachotsa. Pali mwayi wokhala ndi mavuto oopsa oopsa a hypoglycemia, mpaka matenda a edema, kukomoka, chikomokere. Potere, kufunikira kuchipatala mwachangu ndi thandizo loyenerera la ogwira ntchito zamankhwala amafunika.

Mankhwala osokoneza bongo amachitika pakumeza glucose kapena kubaya yankho mu (50%, 50 ml), ndi matenda otupa - mu / Mannitol. Kuphatikiza apo, kuwunika mwadongosolo kuchuluka kwa shuga m'masiku 2 otsatira ndikofunikira.

Wopanga: Lab. Ntchito Yogwira Ntchito, France.

Mtengo wapakati: 310 rub

Chofunikira: Gliclazide. Piritsi lamapiritsi.

Ubwino: samayambitsa zotsatira zoyipa (pafupifupi 1% ya anthu odwala matenda ashuga), kuthamanga kwambiri, kumachepetsa shuga, kuchepetsa mapangidwe a magazi, malangizo osavuta kugwiritsa ntchito.

Zoyipa: okwera mtengo, pang'onopang'ono amatsika--maselo.

Wopanga: Ranbaxi Laboratories Ltd., India.

Mtengo wapakati: 200 rub Chofunikira: Gliclazide. Piritsi lamapiritsi.

Ubwino: bwino matenda a shuga magazi, kuteteza mphamvu pa β-maselo mosiyana ndi m'badwo woyamba sulfonylureas, kumachepetsa mwayi wa thrombosis.

Zoyipa: zovuta kupeza m'mafakitala; kugwiritsa ntchito pafupipafupi pang'onopang'ono kumabweretsa chitukuko cha matenda a shuga a insulin.

Kutulutsa mawonekedwe, kapangidwe kake ndi ma CD

Malangizo omwe adalipo pakugwiritsa ntchito Canon Glyclazide akuwonetsa kuti ali m'gulu la mankhwalawa omwe amachepetsa shuga m'magazi, kuwongolera pakamwa komanso mfundo yoti ikuphatikizidwa m'gulu la anthu a m'badwo wotsatira. Ili ndi mawonekedwe aphale ozungulira, opendekera mbali zonse, yoyera. Malinga ndi ndemanga ya Glyclazide Canon, amadziwika ndi kuwala. Gawo lamapiritsi ndi kutulutsidwa kosasunthika, zomwe zikutanthauza kuti amakhala ndi kuchepetsa komanso pafupipafupi pa mulingo, koma amakhala ndi tanthauzo lokhalitsa. The main constituent ndi gliclazide muyeso wa 30 mg ndi 60 mg. Mndandanda wazinthu zina zowonjezera zimaperekedwa ndi mannitol, magnesium stearate, colloidal silicon dioxide, microcrystalline cellulose.Gliclazide Canon mitengo ku Moscow ndi madera ena ndi okwera mtengo kwambiri kwa nzika zomwe zikuchita izi pochiritsa.

Zotsatira za pharmacological

Ntchito yayikulu ya Canon Gliclazide ndikuyambitsa kupanga kwa insulin beta cell mu kapamba. Mankhwalawa amathandizanso kukulitsa chiwopsezo cha insulin. Mwakutero, ili ndi udindo wothandiza kusintha mphamvu ya ma enzymes mkati mwa maselo. Imafupikitsa nthawi yayitali pakati pa chakudya ndi chiyambi cha kutulutsidwa kwa insulin. Zimakhudzanso kuyambiranso kwa nsonga yoyambirira ya kutulutsidwa kwa insulin ndi kuchepa kwa nsonga ya postprandial ya hyperlycemia. Glyclazide Canon imathandizira kuchepetsa kuphatikizira kwa maselo ndi kunamatira, imachepetsa mapangidwe a parietal thrombi, komanso imapangitsa ntchito ya mtima. Udindo kwa matenda a mtima kupindika. Ilinso ndi zinthu zotsutsana ndi atherogenic, zomwe zimawonetsedwa pakuchepa kwa mafuta m'thupi, kuchuluka kwa HDL-C, ndi kuchepa kwa chiwonetsero chaulere chaulere. Zimalepheretsa atherosclerosis ndi microthrombosis, mapangidwe ake. Imachepetsa kukoka kwa mtima ku adrenaline ndipo imakhala ndi phindu lothandiza pakukweza mtima. Kugwiritsa ntchito kwa nthawi yayitali Canon Glyclazide kumachepetsa proteinuria mu matenda ashuga. Mafuta omwe amapezeka m'matumbo am'mimba amapezeka mofulumira kuposa omwe Canon Gliclazide analogues. Kutupa kumachitika kudzera mu impso pogwiritsa ntchito metabolites, ndipo pafupifupi 1% kudzera mkodzo.

Gliclazide Canon idapangidwa kwa odwala omwe adapeza kupezeka kwa mtundu wa 2 matenda a shuga, kuti achepetse kulemera, komanso kuwonjezera kupirira kwa mota ndi kusinthasintha, ndipo panthawi imeneyo pomwe menyu omwe amakhala ndi zopatsa mphamvu zochepa samabweretsa phindu. Yoyenera ngati prophylaxis yolimbana ndi kuchuluka kwa matenda ashuga: kuti mupewe chiwopsezo cha kukokoloka kwa ma cellvas, polimbana ndi kukokoloka kwa macrovascular - stroke ndi kugunda kwa mtima, mwakuwunikira bwino kwa glycemic.

Zotsatira zoyipa

Zotsatira zoyipa zochokera kugwiritsidwa ntchito kwa mankhwalawa ndi: - matenda a hypoglycemic oyambitsidwa ndi chakudya chosakwanira komanso mlingo woyenera, - kupweteka mutu, - kutopa, - kutuluka thukuta, - kuthamanga mtima, - kufooka ndi kugona, - kuthamanga kwa magazi, - mawonekedwe a nkhawa kwambiri, - mavuto ndi tulo, - mkhalidwe wa arrhasmia, - mantha ndi kupsya mtima, - mawonekedwe a zovuta ndi zida zamalankhulidwe ndi kuwonongeka kwa maonedwe owoneka, - wosakwiya, - - kukwiya, - mkhalidwe wachisoni, - kunjenjemera kumapeto styah - kugwera chikomokere, - kukomoka, - unam'tsalimitsa, - vuto kuthedwa nzeru - chosowa kudziletsa - zikamera wa bradycardia. Ziwalo zam'mimba zimagwira ndi mawonekedwe a kutsegula m'mimba, kusanza, kupweteka kwam'mimba, mavuto amtumbo, nthawi zina pamakhala kulakwika kwa chiwindi.Ndi hepatitis ndi cholestatic jaundice, pakufunika kuletsa chithandizo, kuonjezera mphamvu ya hepatic transaminases, zamchere phosphatase. Ziwalo zomwe zimayambitsa hematopoiesis zimapereka chisonyezo chozunza m'mafupa a hematopoiesis. Kuchepa kwa chiwopsezo cha thupi kumawonekeranso chifukwa cha kuyabwa komanso kuzimiririka thupi, erythema ndi urticaria. Sulfonylurea zotumphukira zimachitika mu vasculitis, erythropenia, hemolytic anemia, pancytopenia, agranulocytosis, komanso kuphwanya chiwindi ntchito, yomwe imatha kukhala pachiwopsezo cha moyo.

Bongo

Panthawi yakupitilira mlingo wovomerezeka wa Canon Glyclazide, pali mwayi wokhala ndi matenda a hypoglycemic, mawonekedwe okomoka komanso chiopsezo chogwera mu kuphwanya kwa hypoglycemic. Zochizira odwala omwe akudziwa, ndikofunikira kutenga shuga mkati. Palinso chiopsezo cha kugwidwa, kusokonezeka kwa mitsempha, chifukwa cha chikhalidwe champhamvu kwambiri cha hypoglycemic. Izi zimafuna kuyankhidwa mwachangu ndi madokotala komanso kuchipatala mwachangu. Pansi pa lingaliro kapena kuzindikira kwa kuperewera kwa hypoglycemic, jakisoni wa 40% ya shuga m'magawo 50 ml amafunikira mwachangu, ndiye, kuti asunge shuga yokwanira, osakaniza 5% a dextrose amawayamwa. Maola angapo otsatira pambuyo poti munthu wabwera ndi vuto lawolo, kuti apewe kubwereza matenda obwera chifukwa cha hypoglycemic, amafunika kumudyetsa chakudya chomwe chili ndi chakudya chambiri cham'mimba chambiri. Kwa maola 48 owonjezerawa, pititsani wodwalayo moyang'aniridwa ndikuwonetsetsa kuchuluka kwa shuga m'magazi. Zowonekeranso zonse zomwe madokotala amatengera zimadalira thanzi lakelo. Momwemonso, malinga ndi kumangiriza kwa gliclazide kuti mapuloteni a plasma, kuyeretsa kwa dialuse sikungathandize.

Kuyanjana kwa mankhwala osokoneza bongo

Kuphatikizidwa kwa Canon Glyclazide ndi anticoagulants ndi nkhani yofunika, chifukwa mankhwalawa amawonjezera mphamvu yawo, yomwe imafunikira kusintha kwa mlingo. Miconazole ikukankha kuti ichulukitse mkhalidwe wa hypoglycemic. Phenylbutazone isanachitike komanso itachitika, pakufunika kuwunika ndikuwunika kuchuluka kwa shuga m'magazi ndikupanga kusintha kwa kuchuluka kwa glyclazide yotengedwa, chifukwa chakuti imathandizira kutsegulitsa kwa hypoglycemic. Mankhwala, kupezeka kwa mowa wa ethyl mu kapangidwe kake, amatha kupititsa patsogolo hypoglycemia, ndikupanga hypoglycemic coma. Kugwiritsa ntchito limodzi kwa Canon Glyclazide ndi mankhwala am'magulu ake (insulin, acarbose), ma beta-blockers, fluconazole, monoamine oxidase inhibitors, H2-histamine receptor blockers, zinthu zosagwiritsa ntchito mankhwala a anti-yotupa, sulfonamides imakulitsa kuchuluka kwa hypoglycemic ndi hypoglycemic. Mphamvu ya Diabetogenic imakhala ndi danazol. Kuchepetsa mapangidwe a insulin ndi kuchuluka kwake m'magazi kumayambitsa kuchuluka kwa chlorpromazine. Kukhazikitsa terbutaline kudzera m'mitsempha, salbutamol ndi ritodrine kumawonjezera ndikudziunjikira shuga. Pakufunika kuwunika momwe mulili wake ndikusintha njira zosankhidwa za chithandizo cha insulin.

Malangizo apadera

Njira yothandizira mankhwalawa ndi Glyclazide Canon imayendera limodzi ndi kukonza zakudya zama calorie otsika, kudya mokwanira komanso kuthanso kwa chakudya cham'mawa komanso kuchuluka kokwanira kwa chakudya. Chifukwa cha kufanana kwa kayendetsedwe ka sulfonylurea, hypoglycemia imatha kukulira, nthawi zina osadutsa popanda jakisoni wa glucose ndikuyika kuchipatala. Kuphatikiza mowa, kutenga othandizira angapo a hypoglycemic ofanana, kuchita masewera olimbitsa thupi kwambiri kungayambitse hypoglycemia. Emotional matenda, kuwunika zakudya kumafuna kusintha kwa mankhwalawa. Kuvulala kwambiri kwa thupi, kupezeka kwa kuwotcha koopsa, matenda oyambitsidwa ndi matenda osiyanasiyana komanso kufunika koperekera chithandizo kwa opaleshoni, komwe kungapangidwe kwa insulin, ndi zinthu zomwe zikufunika kuti kuthetsedwe kwa Glyclazide Canon. Njira yakuchiritsira ndi mankhwalawa imatha kukhudzidwa ndikuyankha mwachangu, kotero kwakanthawi muyenera kusiya kukhala kumbuyo kwa gudumu ndi njira zothandizira zomwe zimafunikira kwambiri. Njira ya mankhwalawa iyenera kutsagana ndi kutsimikiza kwa kuchuluka kwa glucose ndi hemoglobin wa glycosylated m'magazi, ndi kuyika kwake mkodzo.

Glyclazide Canon

Kutetezedwa Kutulutsidwa Mapiritsi yoyera kapena pafupifupi yoyera, yozungulira, ya biconvex, yokhala ndi chiopsezo, kuyenda pang'ono kumaloledwa.

Othandizira: hypromellose (hydroxypropyl methylcellulose) - 100 mg, colicidal silicon dioxide - 7 mg, mannitol - 80 mg, magnesium stearate - 3,6 mg, mafuta a masamba a hydrogenated - 7.2 mg, microcrystalline cellulose - 102.2 mg.

Ma PC 10 - matumba otumphuka (3) - mapaketi okhala ndi makatoni. 10 ma PC. - matumba otulutsa (6) - mapaketi okhala ndi makatoni. ma 15 ma PC. - mapepala otumphukira (2) - mapaketi a makatoni.

15 ma PC. - mapaketi a matuza (4) - mapaketi a makatoni.

Pharmacokinetics

Pambuyo pakumwa pakamwa, imatengedwa mwachangu kuchokera mumimba. Cmax m'magazi imafikira pafupifupi maola 4 mutalandira kamodzi pa 80 mg.

Kumanga mapuloteni a Plasma ndi 94.2%. Vd - pafupifupi 25 l (0,35 l / kg thupi).

Zimapangidwa mu chiwindi ndikupanga 8 metabolites. Metabolite yayikulu ilibe mphamvu ya hypoglycemic, koma imakhudza ma microcirculation.

T1 / 2 - maola 12. Amapukusidwa makamaka ndi impso mu mawonekedwe a metabolites, osakwana 1% omwe amaponyedwa mkodzo osasinthika.

Type 2 shuga mellitus osakwanira mutha kudya mankhwala, zolimbitsa thupi ndi kuchepa thupi.

Kupewa mavuto amtundu wachiwiri wa matenda a shuga: kuchepetsa chiopsezo cha microvascular (nephropathy, retinopathy) ndi macrovascular complication (myocardial infarction, stroke).

Glyclazide MV 30 mg ndi MV 60 mg: malangizo ndi kuwunika kwa odwala matenda ashuga

Gliclazide MV ndi amodzi mwa mankhwala omwe amagwiritsidwa ntchito masiku onse mtundu wa shuga. Ndi gawo lam'badwo wachiwiri wa kukonzekera kwa sulfonylurea ndipo ingagwiritsidwe ntchito onse mu monotherapy komanso mapiritsi ena ochepetsa shuga ndi insulin.

Kuphatikiza pa momwe magazi amasinthira, gliclazide imathandizanso pakupanga magazi, imachepetsa kupsinjika kwa oxidative, imakongoletsa ma microcirculation. Mankhwalawa alibe popanda zovuta zake: amathandizira kulemera, ndikugwiritsa ntchito nthawi yayitali, mapiritsi amatha mphamvu. Ngakhale mankhwala ochulukirapo a gliclazide amatha ndi hypoglycemia, chiwopsezo chake ndi chachikulu kwambiri muukalamba.

Zambiri

Satifiketi yakulembetsa ku Gliclazide MV imaperekedwa ndi kampani yaku Russia Atoll LLC. Mankhwala omwe ali pansi pa mgwirizano amapangidwa ndi kampani ya Samara yopanga mankhwala Ozone. Imapanga ndi kunyamula mapiritsi, ndikuwongolera mtundu wawo.

Gliclazide MV silingatchulidwe ngati mankhwala apanyumba, popeza mankhwala omweyo (amagwiritsidwanso ntchito glyclazide) ku China. Ngakhale izi, palibe cholakwika chomwe chinganenedwe za mtundu wa mankhwalawa.

Malinga ndi odwala matenda ashuga, palibe vuto lililonse kuposa French Diabeteson yofananira.

Mawu achidule a MV m'dzina la mankhwalawa akuwonetsa kuti chinthu chomwe chimagwira mwa iye chimasinthidwa.

Glyclazide amasiya piritsi nthawi yomweyo komanso pamalo oyenera, omwe amawonetsetsa kuti salowa m'magazi nthawi yomweyo, koma m'magawo ang'onoang'ono. Chifukwa cha izi, chiwopsezo cha zotsatira zosafunikira chimachepetsedwa, mankhwalawa amatha kumwa pafupipafupi.

Ngati mapangidwe a piritsi amaphwanyidwa, nthawi yake yayitali imatayika, motero, malangizo ogwiritsira ntchito silimbikitsa kuti azidula.

Glyclazide imaphatikizidwa pamndandanda wazamankhwala ofunikira, chifukwa chake ma endocrinologists ali ndi mwayi wopereka kwa odwala matenda ashuga kwaulere. Nthawi zambiri, malinga ndi zomwe wapatsidwa, ndi MV Gliclazide yomwe ndi analog ya Diabeteson woyambayo.

Kodi mankhwalawa amagwira ntchito bwanji?

Ma gliclazide onse atakhudzidwa m'mimba amatayikiridwa m'magazi ndipo amaphatikizana ndi mapuloteni ake. Nthawi zambiri, shuga amalowa m'maselo a beta ndipo amathandizira zolandilira zapadera zomwe zimapangitsa kutulutsidwa kwa insulin. Glyclazide imagwiranso ntchito mofananamo, kupangitsa mwachilengedwe kuphatikizika kwa mahomoni.

Zotsatira pakupanga insulin sizingokhala ndi zotsatira za MV Glyclazide. Mankhwala amatha:

1. Kuchepetsa kukana insulin. Zotsatira zabwino (kuchuluka kwa insulivivity mwa 35%) zimawonedwa.
2. Kuchepetsa kapangidwe ka shuga ndi chiwindi, potero kumapangitsa kusala kudya.
3. Pewani magazi kuundana.
4. Yambitsani kaphatikizidwe ka nitric oxide, yomwe imakhudzidwa pakukakamiza, kuchepetsa kutupa, komanso kukonza magazi kuti apange ziwalo zotumphukira.
5. Ntchito ngati antioxidant.

Kutulutsa mawonekedwe ndi mlingo

Piritsi Gliclazide MV ndi 30 kapena 60 mg yogwira ntchito.

Zothandizira zothandizira ndi izi: cellulose, yomwe imagwiritsidwa ntchito ngati chochulukitsa, silika ndi magnesium stearate ngati emulsifiers.

Mapiritsi amtundu woyera kapena kirimu, womwe umayikidwa mu matuza a 10-30 zidutswa. Mu paketi ya matuza a 2-3 (mapiritsi 30 kapena 60) ndi malangizo. Glyclazide MV 60 mg imatha kugawidwa pakati, chifukwa izi ndizowopsa pamapiritsi.

Mankhwala amayenera kuledzera pakudya cham'mawa. Gliclazide imagwira ntchito mosasamala kanthu za kupezeka kwa shuga m'magazi. Kuti hypoglycemia isachitike, palibe chakudya chomwe muyenera kudumpha, chilichonse chimayenera kukhala ndi chakudya chofanana. Ndikofunika kuti mudye mpaka katatu pa tsiku.

Malamulo akusankha:

Malangizo atsatanetsatane oti mugwiritse ntchito

Malinga ndi malingaliro azachipatala a Unduna wa Zaumoyo ku Russia, gliclazide iyenera kuyikidwa kuti ikulimbikitse insulin. Moyenerera, kusowa kwa mahomoni akeake kuyenera kutsimikiziridwa ndikuwunika wodwalayo. Malinga ndi ndemanga, izi sizimachitika nthawi zonse. Othandizira ndi ma endocrinologists amapereka mankhwala "ndi maso".

Zotsatira zake, zochuluka kuposa kuchuluka kwa insulin komwe kumatulutsidwa, wodwalayo amafuna kudya nthawi zonse, kulemera kwake kukuwonjezeka pang'onopang'ono, ndipo kubwezeredwa kwa matenda ashuga sikokwanira. Kuphatikiza apo, maselo a beta okhala ndi njira yotereyi amawonongeka mwachangu, zomwe zikutanthauza kuti matendawo amapita gawo lina.

Mungapewe bwanji izi:

1. Yambani kutsatira zakudya za anthu odwala matenda ashuga (tebulo Na. 9, kuchuluka kwa chakudya kokhazikika kwa dokotala kapena wodwalayo malinga ndi glycemia).
2. Fotokozerani zochitika zatsiku ndi tsiku.
3. Kuchepetsa thupi kubwinobwino. Mafuta ochulukirapo amawonjezera shuga.
4. Imwani glucophage kapena mawonekedwe ake. Mulingo woyenera kwambiri ndi 2000 mg.

Ndipo pokhapokha ngati izi sizikwanira shuga wabwinobwino, mutha kuganiza za gliclazide. Musanayambe chithandizo, ndikofunikira kuyesedwa kwa C-peptide kapena insulin kuti muwonetsetse kuti kuphatikizika kwa mahomoni kumavulaza kwenikweni.

Ha glycated hemoglobin ndi yokwera kuposa 8.5%, MV Gliclazide imatha kuperekedwa limodzi ndi zakudya komanso metformin kwakanthawi, mpaka matenda a shuga amalipiridwe. Pambuyo pake, nkhani yosiya mankhwala imasankhidwa payekhapayekha.

Momwe mungatengere panthawi yoyembekezera

Malangizo ogwiritsira ntchito kuletsa chithandizo ndi Gliclazide pa nthawi ya pakati ndi mkaka wa m`mawere. Malinga ndi gulu la FDA, mankhwalawa ndi a m'gulu la C. Izi zikutanthauza kuti zimatha kusokoneza kukula kwa mwana wosabadwayo, koma sizimayambitsa kusokonezeka kwa kubereka. Gliclazide ndiyotetezedwa m'malo ndi mankhwala a insulin musanabadwe, m'malo ovuta kwambiri - kumayambiriro.

Kuthekera kwa kuyamwitsa ndi gliclazide sikunayesedwe. Pali umboni kuti kukonzekera kwa sulfonylurea kumatha kulowa mkaka ndikuyambitsa hypoglycemia mwa makanda, kotero kugwiritsa ntchito panthawiyi ndizoletsedwa.

Yemwe Glyclazide MV wapatukana

Zitha kusintha

Gliclazide ya ku Russia ndiyotsika mtengo, koma m'malo mwake ndi mankhwala apamwamba kwambiri, mtengo wamatayala a Gliclazide MV (30 mg, 60 vipande) wafika mpaka ma ruble 150. M'malo mwake ndi analogues pokhapokha ngati mapiritsi wamba sogulitsidwa.

Mankhwala oyamba ndi Diabeteson MV, mankhwala ena onse omwe ali ndi mawonekedwe omwewo, kuphatikiza Gliclazide MV ndi majenito, kapena makope. Mtengo wa matenda ashuga ndiwotsika pafupifupi 2-3 kuposa ma genetic ake.

Glyclazide MV analogues ndi oloweza olembetsedwa ku Russian Federation (zosintha zakumasulidwa zokhazokha zikuwonetsedwa):

• Glyclazide-SZ yopangidwa ndi Severnaya Zvezda CJSC,
• Golda MV, Pharmasintez-Tyumen,
• Gliclazide Canon kuchokera ku Canonpharm Production,
• Glyclazide MV Malo ogulitsa, Pharmstandard-Tomskkhimfarm,
• Diabetalong, wopanga MS-Vita,
• Gliklada, Krka,
• Glidiab MV kuchokera ku Akrikhin,
• Diabefarm MV Pharmacor Production.

Mtengo wa analogues ndi ma ruble 120-150 pa phukusi lililonse. Gliklada yopangidwa ku Slovenia ndiye mankhwala okwera mtengo kwambiri kuchokera pamndandandawu, paketi imadya pafupifupi ma ruble 250.

Ndemanga Zahudwala

Adasinthidwa ndi Sergei, wazaka 51. Matenda a shuga kwa pafupifupi zaka 10. Posachedwa, shuga wafika 9 m'mawa, motero Glyclazide MV 60 mg adayikidwa. Muyenera kumwa ndi kuphatikiza ndi mankhwala ena, Metformin Canon.

Mankhwala onse komanso zakudya zimapereka zotsatira zabwino, mapangidwe a magazi adabwerera mwakale, patatha mwezi umodzi udaleka kupsya miyendo. Zowona, aliyense akaphwanya chakudyacho, shuga amatuluka mwachangu, kenako pang'onopang'ono amachepa masana. Palibe mavuto, chilichonse chimalekeredwa bwino.

Mankhwala amaperekedwa kwaulere kuchipatala, koma ngakhale mutagula nokha, ndi zotsika mtengo. Mtengo wa Gliclazide ndi 144, Metformin ndi ma ruble 150. Adatsimikiziridwa ndi Elizabeth, wazaka 40. Glyclazide MV adayamba kumwa mwezi watha, endocrinologist adalemba kuwonjezera pa Siofor, pomwe kuwunikaku kunawonetsa pafupifupi 8% ya hemoglobin ya glycated.

Sindinganene chilichonse chokhudza mavutowa, anachepetsa shuga.Koma zovuta zoyipa zidandichotsera mwayi wogwira ntchito. Ntchito yanga imagwira ntchito yoyendayenda; sindimatha kudya nthawi yabwino. Siofor adandikhululukira zolakwa pazakudya, koma ndi Gliclazide chiwerengerochi sichidutsa, ndidachedwa pang'ono - kenako hypoglycemia.

Ndipo zokhwasula-khazikika zanga sizokwanira. Zinafika poti pa gudumu muyenera kutafuna mkaka wotsekemera.

Anayang'aniridwa ndi Ivan, wazaka 44. Posachedwa, m'malo mwa Diabetes, adayamba kupereka Gliclazide MV. Poyamba ndinkafuna kugula mankhwala akale, koma kenako ndidawerenga ndemangazo ndikuganiza zoyesa yatsopano. Sindikumvanso kusiyana, koma ma ruble 600. opulumutsidwa. Mankhwala onse awiriwa amachepetsa shuga komanso amakhala wathanzi. Hypoglycemia ndi osowa kwambiri ndipo nthawi zonse vuto langa. Usiku, shuga sagwa, amafufuzidwa mwapadera.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala amapezeka mu mawonekedwe a mapiritsi, omwe amadziwika ndi kumasulidwa kosasunthika. Wopanga amapereka ma 2 Mlingo: 30 mg ndi 60 mg. Mapiritsiwo ali ndi mawonekedwe a biconvex wozungulira ndi mtundu woyera. Kuphatikizidwa kwa mankhwalawa kumaphatikizapo:

• ntchito yogwira (gliclazide),
• zosakaniza zowonjezera: colloidal silicon dioxide, ma cellcose a cellulose, magnesium stearate (E572), hydroxypropyl methylcellulose, mannitol, mafuta a masamba a hydrogenated.

Mankhwala amapezeka mu mawonekedwe a mapiritsi, omwe amadziwika ndi kumasulidwa kosasunthika.

Ndi chisamaliro

Mankhwala angagwiritsidwe ntchito zolimbitsa kufatsa kwa impso ndi chiwindi. Mankhwalawa amadziwitsidwa mosamala mu zotsatirazi zamikhalidwe ndi zotsatirazi:

• kusasamala kapena kudwala
• matenda endocrine
• matenda oopsa a CVS,
• shuga-6-phosphate dehydrogenase akusowa,
• uchidakwa
• odwala okalamba (azaka 65 ndi akulu).

Chithandizo ndi kupewa matenda ashuga

Mlingo woyambirira wa mankhwalawa pochiza matenda osokoneza bongo omwe amadalira insulin komanso kugwiritsa ntchito sulfonylurea sayenera kupitirira 75-80 g Pazifukwa zodzitetezera, mankhwalawa amagwiritsidwa ntchito pa 30-60 mg / tsiku.

Potere, adotolo amayenera kuyang'anira kuchuluka kwa shuga m'magawo awiri atatha kudya komanso pamimba yopanda kanthu.

Ngatiapezeka kuti mankhwalawo anali osathandiza, ndiye kuti amawonjezeranso masiku angapo.

Mankhwalawa amatha kuzungulira thupi. Komabe, kugwiritsa ntchito mankhwalawa kwa nthawi yayitali, odwala amatha kukumana ndi zovuta.

Pazifukwa zodzitetezera, mankhwalawa amagwiritsidwa ntchito pa 30-60 mg / tsiku.

Pa mbali ya chiwindi ndi biliary thirakiti

• chiwindi
• cholestatic jaundice.

• kutayika kwa chidziwitso,
• kuchuluka kwachulukidwe ka intraocular.

Mankhwalawa amagwiritsidwa ntchito limodzi ndi zakudya zamafuta ochepa.

Mukamamwa, wodwala amayenera kuyang'anira kuchuluka kwa shuga m'magazi.

Mukamamwa mankhwala, wodwalayo amayenera kuwongolera kuchuluka kwa shuga m'magazi.

Mu shuga mellitus mu gawo lowonongeka kapena atachitidwa opaleshoni, mwayi wogwiritsa ntchito insulin uyenera kuganiziridwanso.

Kupangira Glyclazide Canon ya Ana

Mankhwala ndi oletsedwa kugwiritsidwa ntchito ndi ana aang'ono.

Odwala okalamba amaloledwa kugwiritsa ntchito mankhwalawa mosamala kwambiri komanso moyang'aniridwa ndi achipatala.

Sizoletsedwa kugwiritsa ntchito mapiritsiwa ndi hypoglycemic zotsatira ndi matchulidwe a aimpso. Mlingo amasankhidwa payekha malinga ndi odwala omwe ali ndi vuto laimpso.

Osavomerezeka kuphatikiza

Sikoyenera kugwiritsa ntchito mankhwala okhala ndi ethanol ndi mankhwala omwe amapezeka ndi chlorpromazine nthawi imodzi ndi mankhwala omwe mukufunsidwa.

Phenylbutazone, Danazole ndi mowa zimawonjezera hypoglycemic zotsatira za mankhwala. Pankhaniyi, ndikwabwino kusankha mtundu wina wa anti-kutupa.

Kuphatikiza komwe kumafunikira kusamala

Kuphatikiza kwa mankhwalawa ndi Acarbose, beta-blockers, biguanides, Insulin, Enalapril, Captopril ndi mankhwala ena a anti-yotupa omwe si a anti -idal komanso mankhwala okhala ndi chlorpromazine amafunika chisamaliro chapadera, chifukwa munthawi imeneyi mumakhala chiopsezo cha hypoglycemia.

Anthu odwala matenda ashuga

Arkady Smirnov, wazaka 46, Voronezh.

Akadapanda mapiritsi awa, ndiye kuti manja anga akadatsika kalekale. Ndakhala ndikudwala matenda ashuga a 2 kwa nthawi yayitali. Mankhwalawa amawongolera bwino magazi. Zotsatira zoyipa, ndimakumana ndi mseru wokha, koma adadzipatula pambuyo masiku angapo.

Inga Klimova, wazaka 42, Lipetsk.

Mayi anga ali ndi matenda osokoneza bongo omwe amadalira insulin. Adotolo adamupatsa mapiritsiwo. Tsopano adayamba kukhala wokondwa komanso analawa moyo.