Momwe mawonekedwe a thupi amakhudzira chiwopsezo cha matenda ashuga

Kukana kwa insulin komwe kumalumikizidwa ndi mafuta am'mimba

Pali umboni wina kuti kunenepa kwambiri kwamitsempha kumapangitsa kukula kwa matenda ashuga.

Akatswiri apeza kulumikizana pakati pa chikhalidwe cha majini kuti achulukane mafuta pamimba ndi matenda a shuga a 2, komanso matenda a mtima ndi stroko.

Kafukufukuyu akuchokera pa anthu pafupifupi 200,000 ochokera ku Europe ndi United States. Kuwunika kwa meta kunayang'ana zotsatira zakusintha kwa majini pa insulin chiwopsezo ndi mafuta kagayidwe. Kuwunika kwa meta ndi njira yosavuta yoperekera mwachidule maphunziro angapo omwe amafufuza za zomwezo kapena zofanana. Cholinga cha phunziroli chinali kupeza mgwirizano pakati pa ma genotypes osiyanasiyana ndikupanga chithunzi chamafuta chamafuta, komanso insulin.

Asayansi adasanthula mtundu wamtundu wa anthu pafupifupi 200,000 kuti adziwe kusintha kwa majini omwe amagwirizana ndi insulin. Kenako adayang'ananso momwe kusinthika kwa ma genetic kumathandizira kukula kwa matenda a mtima.

Matenda a Cardiometabolic Kodi mawu ofanana ndi omwe amagwiritsidwa ntchito pofotokoza za matenda omwe amayambitsidwa ndi zovuta za metabolic ndi magazi, monga matenda a shuga ndi matenda a mtima.

Miyezo yamafuta amthupi osiyanasiyana magawo osiyanasiyana amafanizidwa ndi wina ndi mzake kuti apeze omwe ali pachiwopsezo chachikulu cha kukula kwa matenda a mtima. Akatswiri anazindikira kuti chibadwa cha kufalitsa mafuta m'thupi la munthu chimakhudza mwachindunji matenda a insulin komanso matenda ena okhudzana ndi mtima.

Kudzikundikira kwamafuta m'thupi. Mafuta ochulukirapo.

Anthu amadzola mafuta m'thupi m'njira zosiyanasiyana. Wina wamafuta ambiri amakhala m'chiuno, wina pakhosi kapena m'manja. Zachidziwikire, izi sizimawonjezera kukopa kwa munthu, koma sizowopsa ngati mafuta oyikiridwa m'mimba. Mafuta otchedwa visceral omwe amasonkhana m'matumbo am'mimba (makamaka mozungulira chiwindi ndi kapamba) ndiowopsa kwambiri thanzi.

Zimatsimikiziridwa kuti mafuta visceral zokhudzana mwachindunji ndi matenda a shuga a 2 komanso insulin - mkhalidwe womwe maselo amthupi sangayankhe ku insulin ya mahomoni.

Kusiyana kumeneku pakugawa mafuta m'thupi kumatha kufotokoza pang'ono chifukwa chake anthu onse osaneneka amakhala ndi matenda ashuga a 2 komanso mosiyanasiyana, chifukwa chake nthawi zina matendawa amaperekedwa kwa iwo omwe ali ndi thupi labwinobwino.

Kuphatikiza pa kuyanjana pakati pakugawidwa kwa mafuta m'thupi ndi kukana insulini (insulin kukana), asayansi adapezanso zodetsa nkhawa m'magawo 53 a majini omwe adawonjezera mwayi wokhala ndi insulin kukana ndikupangitsa matenda ashuga a 2. Kafukufuku wam'mbuyomu adatha kudziwa gawo limodzi mwa magawo khumi amtunduwu. Momwe zilipo zambiri, pamakhala chiopsezo cha matenda a shuga. Chifukwa chake, kafukufuku watsopano adatha kudziwa ubale womwe ulipo pakati pa magulu amtunduwu komanso kugawidwa kwamafuta mthupi.

Zotsatirazo zingathandize akatswiri kupanga njira zothandizira kupewa ndi kuchiza matenda amishuga amtundu wa 2, potengera mawonekedwe omwe amagawika mafuta mthupi la wodwala wina.

Type 2 matenda a shuga

Insulin ndi mahomoni achilengedwe omwe amathandiza kuwongolera shuga. Pamene kukana insulini kukukwera, pamakhala kuchuluka kwa shuga m'magazi ndi kuchuluka kwama cell (lipids), zomwe zimawonjezera mwayi wokhala ndi matenda ashuga komanso mtima.

Mafuta okhathamira, omwe amakhala m'mimba, komanso ozungulira ziwalo zamkati, makamaka kuzungulira chiwindi ndi kapamba, zimabweretsa chiwopsezo chachikulu thanzi.

Mutha kuchepetsa chiwopsezo chanu chokhala ndi matenda amtundu wa 2 osadikirira tekinoloje yatsopano. Kuti muchite izi, ndikokwanira kusintha moyo wanu:

• Muzidya zakudya zopatsa thanzi,
• lekani kusuta kwathunthu,
• kusiya kapena kuchepetsa kumwa,
• pitani m'masewera pafupipafupi.

Ngati mukuyamba zizindikiro za matenda ashuga: kutopa, chizungulire, kupanikizika kwamphamvu, ludzu pafupipafupi - muyenera kufunsa dokotala nthawi yomweyo.

Mitundu ya thupi

Akatswiri amati komwe mumasungira mafuta ochulukirapo kumatha kutsimikiziridwa mwamaumbidwe - mwanjira ina, ngati amayi anu ali ndi nkhawa ndi "m'mimba" yake, inunso mungatero. Ndipo mawonekedwe amthupi omwe adapangidwa ndi mafuta amthupi awa atha kulosera za chiwopsezo chanu chokhala ndi matenda a shuga a 2:

• Apulo. Anthu omwe mafuta awo amapanga mchiuno mwake amatha kumawoneka ngati apulo. Mtundu wamtunduwu umatchedwanso "Android" ndipo kudziunjikira kwamafuta kumatchedwa "kunenepa kwambiri."
• Ngale Makamaka mwa akazi, mafuta amatha kumanga matako ndi m'chiuno. Nkhani yabwino ndiyakuti mtundu wamafuta awa umakhala wochepa kwambiri kuposa mafuta am'mimba omwe ungayambitse insulin kukana kapena mtundu wa 2 shuga.
• Mwambiri. Mwa anthu ena, mafuta amasonkhanitsidwa thupi lonse moyenera. Ndipo popeza kunenepa kwambiri kapena kunenepa kwambiri, mosasamala kanthu za momwe thupi limapangidwira, kumakulitsa chiopsezo chokhala ndi matenda a shuga a 2, chakuti simulowa mu mawonekedwe a thupi la apulo kapena peyala sikukuchotsani kwathunthu ku mbewa pakufika popewa matenda ashuga Mitundu iwiri komanso matenda ena osachiritsika.

Kukula kwamchiuno

Anthu ena amatha kuwona ngati mawonekedwe awo apangidwe ngati apulo kapena peyala. Koma ngati chiwopsezo chanu chotenga matenda ashuga sichimveka kuchokera pakungoyang'ana pakalilore, pali gawo limodzi lofunika lomwe lingakuthandizeni kudziwa ngozi yopezeka ndi matenda ashuga komanso matenda a mtima: m'chiuno mwanu. Ngati ndinu mkazi ndipo chiuno chanu ndichoposa 89 masentimita, ndiye kuti muli pachiwopsezo chotenga matenda a shuga. Kwa amuna, nambala yamatsenga ndi masentimita 101. Ngati muyeso wa tepi yanu uwonetsedwa kapena kupitirira manambala, ndiye nthawi yochepetsa chiuno chanu.

Chithandizo

Nkhani yabwino ndiyakuti mawonekedwe a thupi lanu si matenda. Pali njira imodzi yayikulu yochepetsera chiopsezo cha matenda a shuga a mtundu wachiwiri: kutaya ndi kukhalabe ndi thanzi labwino.

Nazi njira zomwe mungachite:

• Khalani olimbitsa thupi.Zochita zolimbitsa thupiZatsimikiziridwa kuti zikuthandizani kupewa matenda a shuga ndikuwongolera kunenepa kwanu. Phatikizani zochitika zanu, kuphatikiza ntchito za aerobic monga kuyenda kapena kusambira, komanso maphunziro ena olimbitsa, omwe mungapindule nawo phindu lonse la kuchepa thupi.
• Penyani kunenepa kwanu. Ngati mukudziwa kale kuti ndinu apulo kapena peyala, ndiye kuti ndinu onenepa kwambiri. Kubwerera kulemera kwabwino ndiye chisankho chabwino kwambiri popewa matenda ashuga. Ngati mukuvutikira kusintha kulemera kwanu, funsani dokotala.
• Idyani zakudya zopatsa thanzi. Chakudya chopatsa thanzi, chosiyanasiyana, chomwe chimakhala ndi tirigu wathunthu, zipatso, ndi ndiwo zamasamba ndicho chisankho chabwino kwambiri chathanzi lalitali. Ngati mungatero prediabetes kapena mukudwala kale matenda ashuga, muyenera kuthandiziranso shuga. Yesetsani menyu osakhala ndi mafuta ambiri ngati mukufuna kupukusa m'chiuno mwanu.

Ngati mawonekedwe a thupi omwe mumawaona pagalasi siomwe mungafune kuwona, musataye mtima. Popeza mudalimbikira nokha pang'ono, mutha kuthana ndi vuto lanu la matenda ashuga - kumva bwino komanso kuwoneka bwino.

Kugawa Mafuta

Pakatikati pa kafukufuku yemwe atchulidwa kale panali mtundu wotchedwa KLF14. Ngakhale sizikhudza kulemera kwa munthu, ndi mtundu womwe umasankha komwe malo ogulitsa mafuta azisungirako.

Zinapezeka kuti mwa akazi, mitundu yosiyanasiyana ya KLF14 imagawa mafuta m'madimba amafuta kapena m'chiuno kapena pamimba. Amayi amakhala ndi maselo ochepera ((modabwitsa!), Koma ndi okulirapo ndipo "ali ndi mafuta" enieni. Chifukwa cha izi, minofu yamafuta imasungidwa ndikudya thupi mosakwanira, zomwe zimathandizira kuti pakhale vuto la metabolic, makamaka matenda ashuga.

Ofufuzawo akuti: ngati mafuta ochulukirapo amasungidwa m'chiuno, samangokhala mu njira za metabolic ndipo samachulukitsa chiopsezo chokhala ndi matenda ashuga, koma ngati "malo ake" amasungidwa pamimba, izi zimawonjezera chiwopsezo chomwe chatchulidwa pamwambapa.

Ndikofunika kudziwa kuti kusinthasintha kwa mtundu wa KLF14 kumene, komwe kumapangitsa kuti malo ogulitsa mafuta azikhala m'chiuno, kumawonjezera chiopsezo chokhala ndi matenda ashuga okha mwa azimayi omwe amayi omwe adawalandira kuchokera kwa amayi. Zowopsa zawo ndizokwera 30%.

Chifukwa chake, zidadziwika kuti pakupanga shuga, osati chiwindi ndi kapamba zomwe zimapanga insulin zimathandizanso, komanso maselo amafuta.

Chifukwa chiyani izi ndizofunikira?

Asayansi sanadziwebe chifukwa chomwe jiniyi imakhudzira ma metabolism okha mwa akazi, komanso ngati nkotheka kugwiritsa ntchito mwanjira imeneyi kwa amuna.

Komabe, zikuwonekeratu kuti kupezeka kwatsopano ndi gawo limodzi pachitukuko cha mankhwala omwe ali ndi munthu, ndiye kuti, mankhwala potengera mawonekedwe amtundu wa wodwalayo. Mayendedwe awa akadali achichepere, koma olimbikitsa kwambiri. Makamaka, kumvetsetsa komwe majini a KLF14 amalola kuwunika koyambirira kuti athe kuwunika kuwopsa kwa munthu winawake komanso kupewa kuteteza matenda ashuga. Gawo lotsatira likhoza kukhala kusintha mtunduwu kuti muchepetse zoopsa.

Pakadali pano, asayansi akugwira ntchito, titha kuyambanso ntchito yoteteza thupi lathu. Madokotala amatopa kunena za kuopsa kokhala wonenepa kwambiri, makamaka ikafika ma kilogalamu m'chiwuno, ndipo tsopano tili ndi mkangano umodzi wosatinyoza kulimbitsa thupi ndi kuchita masewera olimbitsa thupi.